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IL-22bp

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https://www.readbyqxmd.com/read/28627588/il%C3%A2-22-expression-is-increased-variedly-in-the-initial-phase-onset-and-chronic-phase-of-a-pristane%C3%A2-induced-arthritis-rat-model
#1
Weikun Hou, Bo Wang, Yan Zhou, Ke Xu, Liesu Meng, Wenhua Zhu, Congshan Jiang, Peng Xu, Shemin Lu
The aim of the present study was to investigate the expression pattern of T helper (Th) 17 and Th22 cell-related factors in a pristane‑induced arthritis (PIA) rat model. PIA rats were divided into the initial phase group [day (D) 6 post‑pristane injection], the onset of clinical arthritis group (D12), the acute arthritis group (D26) and the chronic arthritis group (D70). Rats injected with saline alone were used as the control group. The mRNA expression levels of interleukin (IL)‑17A, IL‑17F, interferon (IFN)‑γ, IL‑22, IL‑22 receptor (R) 1, IL‑22 binding protein (BP) and RAR‑related orphan receptor α were examined in the spleen and/or synovium of the various phases of PIA rats by reverse transcription‑quantitative polymerase chain reaction analysis...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28579463/modified-apple-polysaccharide-prevents-colitis-through-modulating-il-22-and-il-22bp-expression
#2
Yuhua Li, Lei Fan, Tianle Tang, Yuan Tang, Ming Xie, Xiaocong Zeng, Yang Sun, Qibing Mei
Chronic intestinal inflammation enhances cell proliferation, angiogenesis, and migration, then promotes the development of colorectal cancer (CRC). Many ingredients of apples have been proven to have anti-inflammatory properties, and show benefits for colitis treatment. In our previous studies, we found modified apple polysaccharide (MAP) could prevent colitis associated colorectal carcinogenesis effectively. Herein, we further our study to observe the effect of MAP on dextran sodium sulfate (DSS)-induced colitis and to investigate the possible mechanisms...
June 1, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28512157/il-22bp-dictates-characteristics-of-peyer-s-patch-follicle-associated-epithelium-for-antigen-uptake
#3
Toshi Jinnohara, Takashi Kanaya, Koji Hase, Sayuri Sakakibara, Tamotsu Kato, Naoko Tachibana, Takaharu Sasaki, Yusuke Hashimoto, Toshiro Sato, Hiroshi Watarai, Jun Kunisawa, Naoko Shibata, Ifor R Williams, Hiroshi Kiyono, Hiroshi Ohno
Interleukin-22 (IL-22) acts protectively and harmfully on intestinal tissue depending on the situation; therefore, IL-22 signaling needs to be tightly regulated. IL-22 binding protein (IL-22BP) binds IL-22 to inhibit IL-22 signaling. It is expressed in intestinal and lymphoid tissues, although its precise distribution and roles have remained unclear. In this study, we show that IL-22BP is highly expressed by CD11b(+)CD8α(-) dendritic cells in the subepithelial dome region of Peyer's patches (PPs). We found that IL-22BP blocks IL-22 signaling in the follicle-associated epithelium (FAE) covering PPs, indicating that IL-22BP plays a role in regulating the characteristics of the FAE...
June 5, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28492497/regulation-of-th17-cells-and-associated-cytokines-in-wound-healing-tissue-regeneration-and-carcinogenesis
#4
REVIEW
Leonie Brockmann, Anastasios D Giannou, Nicola Gagliani, Samuel Huber
Wound healing is a crucial process which protects our body against permanent damage and invasive infectious agents. Upon tissue damage, inflammation is an early event which is orchestrated by a multitude of innate and adaptive immune cell subsets including TH17 cells. TH17 cells and TH17 cell associated cytokines can impact wound healing positively by clearing pathogens and modulating mucosal surfaces and epithelial cells. Injury of the gut mucosa can cause fast expansion of TH17 cells and their induction from naïve T cells through Interleukin (IL)-6, TGF-β, and IL-1β signaling...
May 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28450947/the-inflammatory-cytokine-il-22-promotes-murine-gliomas-via-proliferation
#5
Xiguo Liu, Junjing Yang, Wankai Deng
Interleukin (IL)-22 is newly identified proinflammatory cytokine involved in the T helper (Th)17 and Th22 response. However, the possible role of IL-22 in glioma remains uncertain. The results of the present study demonstrated higher expression levels of IL-22 and the receptor IL-22BP in the brain of GL261 glioma-inoculation mice, suggesting the regulatory role of IL-22 in glioma. Injection of IL-22 increased the severity of glioma in vivo and higher expression levels of IL-6, IL-1β and tumor necrosis factor (TNF)-α were detected in the brain using ELISA following IL-22 injection...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28356382/limited-presence-of-il-22-binding-protein-a-natural-il-22-inhibitor-strengthens-psoriatic-skin-inflammation
#6
Jérôme C Martin, Kerstin Wolk, Gaëlle Bériou, Ahmed Abidi, Ellen Witte-Händel, Cédric Louvet, Georgios Kokolakis, Lucile Drujont, Laure Dumoutier, Jean-Christophe Renauld, Robert Sabat, Régis Josien
Psoriasis is a chronic inflammatory disease resulting from dysregulated immune activation associated with a large local secretion of cytokines. Among them, IL-22 largely contributes to epithelial remodeling and inflammation through inhibiting the terminal differentiation of keratinocytes and inducing antimicrobial peptides and selected chemokines. The activity of IL-22 is regulated by IL-22 binding protein (IL-22BP); however, the expression and role of IL-22BP in psoriatic skin has remained unknown so far. Here we showed that nonaffected skin of psoriasis patients displayed lower expression of IL-22BP than skin of healthy controls...
May 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27846573/a-pathogenic-role-for-t-cell-derived-il-22bp-in-inflammatory-bowel-disease
#7
Penelope Pelczar, Mario Witkowski, Laura Garcia Perez, Jan Kempski, Anna G Hammel, Leonie Brockmann, Dörte Kleinschmidt, Sandra Wende, Cathleen Haueis, Tanja Bedke, Marco Witkowski, Susanne Krasemann, Stefan Steurer, Carmen J Booth, Philipp Busch, Alexandra König, Ursula Rauch, Daniel Benten, Jakob R Izbicki, Thomas Rösch, Ansgar W Lohse, Till Strowig, Nicola Gagliani, Richard A Flavell, Samuel Huber
Intestinal inflammation can impair mucosal healing, thereby establishing a vicious cycle leading to chronic inflammatory bowel disease (IBD). However, the signaling networks driving chronic inflammation remain unclear. Here we report that CD4(+) T cells isolated from patients with IBD produce high levels of interleukin-22 binding protein (IL-22BP), the endogenous inhibitor of the tissue-protective cytokine IL-22. Using mouse models, we demonstrate that IBD development requires T cell-derived IL-22BP. Lastly, intestinal CD4(+) T cells isolated from IBD patients responsive to treatment with antibodies against tumor necrosis factor-α (anti-TNF-α), the most effective known IBD therapy, exhibited reduced amounts of IL-22BP expression but still expressed IL-22...
October 21, 2016: Science
https://www.readbyqxmd.com/read/27678220/human-il-22-binding-protein-isoforms-act-as-a-rheostat-for-il-22-signaling
#8
Chrissie Lim, MeeAe Hong, Ram Savan
The cytokine interleukin-22 (IL-22), which is a member of the IL-10 family, is produced exclusively by immune cells and activates signal transducer and activator of transcription 3 (STAT3) in nonimmune cells, such as hepatocytes, keratinocytes, and colonic epithelial cells, to drive various processes central to tissue homeostasis and immunosurveillance. Dysregulation of IL-22 signaling causes inflammatory diseases. IL-22 binding protein (IL-22BP; encoded by IL22RA2) is a soluble IL-22 receptor, which antagonizes IL-22 activity and has genetic associations with autoimmune diseases...
2016: Science Signaling
https://www.readbyqxmd.com/read/27524110/the-aim2-inflammasome-is-a-central-regulator-of-intestinal-homeostasis-through-the-il-18-il-22-stat3-pathway
#9
Rojo A Ratsimandresy, Mohanalaxmi Indramohan, Andrea Dorfleutner, Christian Stehlik
Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However, the inflammasome sensor absent in melanoma 2 (AIM2) protects against colorectal cancer in an inflammasome-independent manner through DNA-dependent protein kinase and Akt pathways. Yet, the roles of the AIM2 inflammasome in IBD and the early phases of colorectal cancer remain ill-defined...
January 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27446456/association-between-cxcr2-and-il-22bp-expression-indicate-a-poor-outcome-for-gastric-adenocarcinoma-progression
#10
Shi Bin Yang, Fanghai Han, Jian Hai Wu, Zhi Zhao, Wenhua Zhan
C-X-C motif chemokine receptor type 2 (CXCR2), a key regulatory protein, has been associated with multiple roles in the progression of numerous tumors, including gastric adenocarcinoma (GA). However, the mechanism of CXCR2 in the development of tumors remains controversial and unclear. In a previous study, the expression of CXCR2 and interleukin-22 receptor 2 (IL-22BP) was observed in GA. This promoted the present study, which aimed to explore the association between the two proteins, and to further analyze their roles in GA...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27234655/keratin-8-deletion-induced-colitis-predisposes-to-murine-colorectal-cancer-enforced-by-the-inflammasome-and-il-22-pathway
#11
Julia O Misiorek, Iris A K Lähdeniemi, Joel H Nyström, Valeriy M Paramonov, Josef A Gullmets, Helena Saarento, Adolfo Rivero-Müller, Trine Husøy, Pekka Taimen, Diana M Toivola
Keratins (K) are intermediate filament proteins important in protection from cellular stress. K8, K18 and K19 are the main components of keratin filaments in colonic epithelia but their role in intestinal diseases remains ambiguous. A function for keratins in intestinal health is supported by the K8-knock-out (K8(-/-)) mouse which manifests an early chronic ulcerative colitis-like inflammatory bowel disease and epithelial hyperproliferation. We tested whether K8(-/-) mice are more susceptible to colorectal cancer (CRC) compared to K8 wild type (K8(+/+)), and K8 heterozygote (K8(+/-)) mice showing increased proliferation but no inflammation...
August 2016: Carcinogenesis
https://www.readbyqxmd.com/read/26329427/il-22bp-is-produced-by-eosinophils-in-human-gut-and-blocks-il-22-protective-actions-during-colitis
#12
J C Martin, G Bériou, M Heslan, C Bossard, A Jarry, A Abidi, P Hulin, S Ménoret, R Thinard, I Anegon, C Jacqueline, B Lardeux, F Halary, J-C Renauld, A Bourreille, R Josien
Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel diseases (IBDs), are characterized by high levels of IL-22 production. Rodent studies revealed that this cytokine is protective during colitis but whether this is true in IBDs is unclear. We show here that levels of the soluble inhibitor of IL-22, interleukin 22-binding protein (IL-22BP), are significantly enhanced during IBDs owing to increased numbers of IL-22BP-producing eosinophils, that we unexpectedly identify as the most abundant source of IL-22BP protein in human gut...
March 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/26077779/interleukin-22-is-increased-in-multiple-sclerosis-patients-and-targets-astrocytes
#13
Guillaume Perriard, Amandine Mathias, Lukas Enz, Mathieu Canales, Myriam Schluep, Melanie Gentner, Nicole Schaeren-Wiemers, Renaud A Du Pasquier
BACKGROUND: Increasing evidences link T helper 17 (Th17) cells with multiple sclerosis (MS). In this context, interleukin-22 (IL-22), a Th17-linked cytokine, has been implicated in blood brain barrier breakdown and lymphocyte infiltration. Furthermore, polymorphism between MS patients and controls has been recently described in the gene coding for IL-22 binding protein (IL-22BP). Here, we aimed to better characterize IL-22 in the context of MS. METHODS: IL-22 and IL-22BP expressions were assessed by ELISA and qPCR in the following compartments of MS patients and control subjects: (1) the serum, (2) the cerebrospinal fluid, and (3) immune cells of peripheral blood...
2015: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/25880879/interleukin-il-22-receptor-1-is-over-expressed-in-primary-sjogren-s-syndrome-and-sj%C3%A3-gren-associated-non-hodgkin-lymphomas-and-is-regulated-by-il-18
#14
F Ciccia, G Guggino, A Rizzo, M Bombardieri, S Raimondo, F Carubbi, A Cannizzaro, G Sireci, F Dieli, G Campisi, R Giacomelli, Paola Cipriani, G De Leo, R Alessandro, G Triolo
The aim of this study was to elucidate more clearly the role of interleukin (IL)-18 in modulating the IL-22 pathway in primary Sjögren's syndrome (pSS) patients and in pSS-associated lymphomas. Minor salivary glands (MSGs) from patients with pSS and non-specific chronic sialoadenitis (nSCS), parotid glands biopsies from non-Hodgkin lymphomas (NHL) developed in pSS patients, were evaluated for IL-18, IL-22, IL-22 receptor 1 (IL-22R1), IL-22 binding protein (IL-22BP) and signal transducer and activator of transcription-3 (STAT-3) expression...
August 2015: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/25476703/il-22-and-il-22-binding-protein-il-22bp-regulate-fibrosis-and-cirrhosis-in-hepatitis-c-virus-and-schistosome-infections
#15
Mathieu Sertorio, Xunya Hou, Rodrigo F Carmo, Hélia Dessein, Sandrine Cabantous, Mohammed Abdelwahed, Audrey Romano, Fernanda Albuquerque, Luydson Vasconcelos, Theomira Carmo, Jun Li, Arthur Varoquaux, Violaine Arnaud, Pablo Oliveira, Anas Hamdoun, Hongbin He, Suzan Adbelmaboud, Adil Mergani, Jie Zhou, Ahmed Monis, Leila Beltrao Pereira, Philippe Halfon, Marc Bourlière, Raymundo Parana, Mitermayer Dos Reis, David Gonnelli, Patricia Moura, Nasr Eldin Elwali, Laurent Argiro, Yuesheng Li, Alain Dessein
UNLABELLED: Interleukin (IL)-22 acts on epithelia, hepatocytes, and pancreatic cells and stimulates innate immunity, tissue protection, and repair. IL-22 may also cause inflammation and abnormal cell proliferation. The binding of IL-22 to its receptor is competed by IL-22 binding protein (IL-22BP), which may limit the deleterious effects of IL-22. The role of IL-22 and IL-22BP in chronic liver diseases is unknown. We addressed this question in individuals chronically infected with schistosomes or hepatitis C virus (HCV)...
April 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/25086075/increased-urinary-interleukin-22-binding-protein-levels-correlate-with-lupus-nephritis-activity
#16
Xuyan Yang, Yin Gao, Huiying Wang, Xiaoying Zhao, Xubo Gong, Qingqing Wang, Xiaofei Zhang
OBJECTIVE: Interleukin 22 (IL-22) plays an important role in the promotion of antimicrobial immunity. However, dysregulated IL-22 action leads to inflammation and is involved in autoimmune diseases, including systemic lupus erythematosus (SLE). IL-22 binding protein (IL-22BP) is a soluble inhibitory IL-22 receptor and may represent a crucial regulator of IL-22. We investigated the expression and potential significance of serum and urinary IL-22BP levels in patients with SLE. METHODS: A total of 112 patients with SLE and healthy control subjects participated in our study...
September 2014: Journal of Rheumatology
https://www.readbyqxmd.com/read/25008863/the-multiple-sclerosis-risk-gene-il22ra2-contributes-to-a-more-severe-murine-autoimmune-neuroinflammation
#17
H Laaksonen, A O Guerreiro-Cacais, M Z Adzemovic, R Parsa, M Zeitelhofer, M Jagodic, T Olsson
Single-nucleotide polymorphisms close to IL22RA2, coding for the soluble interleukin (IL)-22-binding protein (IL-22BP), are strongly and reproducibly associated with multiple sclerosis (MS), but there is little data on how this molecule may affect neuroinflammation. Here, we have studied the mouse ortholog in C57BL/6 wild-type and Il22ra2-deficient mice in the context of experimental autoimmune encephalomyelitis (myelin oligodendrocyte glycoprotein-EAE). In wild-type mice, we demonstrated changes in the levels of transcripts for IL-22, the signaling IL-22 receptor and IL-22BP in lymphoid tissues at the time of T-cell priming and in the inflamed central nervous system (CNS)...
October 2014: Genes and Immunity
https://www.readbyqxmd.com/read/24599919/activated-il-22-pathway-occurs-in-the-muscle-tissues-of-patients-with-polymyositis-or-dermatomyositis-and-is-correlated-with-disease-activity
#18
Francesco Ciccia, Aroldo Rizzo, Riccardo Alessandro, Giuliana Guggino, Rosario Maugeri, Laura Saieva, Alessandra Cannizzaro, AnnaRita Giardina, Giacomo De Leo, Domenico Gerardo Iacopino, Giovanni Triolo
OBJECTIVE: The aim of this study was to assess the expression of IL-22, IL-22 receptor 1 (IL-22R1), IL-22 binding protein (IL-22BP) and p-STAT3 in muscle tissue from patients with PM and DM. METHODS: Levels of IL-22, IL-22R1, IL-22BP and STAT3 mRNA were quantified by RT-PCR. The expression of IL-22, IL-22R1, IL-22BP and p-STAT3 was also analysed using immunohistochemistry. RESULTS: Significant modulation of the IL-22 pathway was observed in inflammatory myopathic tissues...
July 2014: Rheumatology
https://www.readbyqxmd.com/read/23653115/interleukin-22-binding-protein-il-22bp-is-constitutively-expressed-by-a-subset-of-conventional-dendritic-cells-and-is-strongly-induced-by-retinoic-acid
#19
J C J Martin, G Bériou, M Heslan, C Chauvin, L Utriainen, A Aumeunier, C L Scott, A Mowat, V Cerovic, S A Houston, M Leboeuf, F X Hubert, C Hémont, M Merad, S Milling, R Josien
Interleukin-22 (IL-22) is mainly produced at barrier surfaces by T cells and innate lymphoid cells and is crucial to maintain epithelial integrity. However, dysregulated IL-22 action leads to deleterious inflammation and is involved in diseases such as psoriasis, intestinal inflammation, and cancer. IL-22 binding protein (IL-22BP) is a soluble inhibitory IL-22 receptor and may represent a crucial regulator of IL-22. We show both in rats and mice that, in the steady state, the main source of IL-22BP is constituted by a subset of conventional dendritic cells (DCs) in lymphoid and non-lymphoid tissues...
January 2014: Mucosal Immunology
https://www.readbyqxmd.com/read/23075849/il-22bp-is-regulated-by-the-inflammasome-and-modulates-tumorigenesis-in-the-intestine
#20
Samuel Huber, Nicola Gagliani, Lauren A Zenewicz, Francis J Huber, Lidia Bosurgi, Bo Hu, Matija Hedl, Wei Zhang, William O'Connor, Andrew J Murphy, David M Valenzuela, George D Yancopoulos, Carmen J Booth, Judy H Cho, Wenjun Ouyang, Clara Abraham, Richard A Flavell
Chronic mucosal inflammation and tissue damage predisposes patients to the development of colorectal cancer. This association could be explained by the hypothesis that the same factors and pathways important for wound healing also promote tumorigenesis. A sensor of tissue damage should induce these factors to promote tissue repair and regulate their action to prevent development of cancer. Interleukin 22 (IL-22), a cytokine of the IL-10 superfamily, has an important role in colonic epithelial cell repair, and its levels are increased in the blood and intestine of inflammatory bowel disease patients...
November 8, 2012: Nature
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