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5-hydroxytryptophan

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https://www.readbyqxmd.com/read/29174366/dnajc12-deficiency-a-new-strategy-in-the-diagnosis-of-hyperphenylalaninemias
#1
REVIEW
Nenad Blau, Aurora Martinez, Georg F Hoffmann, Beat Thöny
Patients with hyperphenylalaninemia (HPA) are detected through newborn screening for phenylketonuria (PKU). HPA is known to be caused by deficiencies of the enzyme phenylalanine hydroxylase (PAH) or its cofactor tetrahydrobiopterin (BH4). Current guidelines for the differential diagnosis of HPA would, however, miss a recently described DNAJC12 deficiency. The co-chaperone DNAJC12 is, together with the 70kDa heat shock protein (HSP70), responsible for the proper folding of PAH. All DNAJC12-deficient patients investigated to date responded to a challenge with BH4 by lowering their blood phenylalanine levels...
November 20, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29147087/hydrolysate-preparation-with-high-content-of-5-hydroxytryptophan-from-liquid-egg-protein-and-its-sleep-potentiating-activity
#2
Jung Il Kwon, Yooheon Park, Sung Hee Han, Hyung Joo Suh
Alcalase hydrolysis of liquid egg white was used to produce 5-hydroxytryptophan (HTP) under various conditions and investigate the sleep-potentiating activity of liquid egg white hydrolysate (LEH) on pentobarbital-induced sleep. Alcalase hydrolysis yielded the highest content of 5-HTP (13.50 μg/mL), while neutrase hydrolysis showed the lowest 5-HTP content (5.23 μg/mL). The liquid egg white to water ratio (1:1) was optimal for the production of 5-HTP with high amino-nitrogen (A-N) content and degree of hydrolysis...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29141182/optogenetic-activation-of-5-ht-neurons-in-the-dorsal-raphe-suppresses-seizure-induced-respiratory-arrest-and-produces-anticonvulsant-effect-in-the-dba-1-mouse-sudep-model
#3
Honghai Zhang, Haiting Zhao, Chang Zeng, Christa Van Dort, Carl L Faingold, Norman E Taylor, Ken Solt, Hua-Jun Feng
Sudden unexpected death in epilepsy (SUDEP) is a devastating epilepsy complication. Seizure-induced respiratory arrest (S-IRA) occurs in many witnessed SUDEP patients and animal models as an initiating event leading to death. Thus, understanding the mechanisms underlying S-IRA will advance the development of preventive strategies against SUDEP. Serotonin (5-HT) is an important modulator for many vital functions, including respiration and arousal, and a deficiency of 5-HT signaling is strongly implicated in S-IRA in animal models, including the DBA/1 mouse...
November 13, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28953038/an-open-label-pilot-study-of-combined-augmentation-with-creatine-monohydrate-and-5-hydroxytryptophan-for-selective-serotonin-reuptake-inhibitor-or-serotonin-norepinephrine-reuptake-inhibitor-resistant-depression-in-adult-women
#4
Brent M Kious, Hana Sabic, Young-Hoon Sung, Douglas G Kondo, Perry Renshaw
PURPOSE: Many women with major depressive disorder (MDD) respond inadequately to standard treatments. Augmentation of conventional antidepressants with creatine monohydrate and 5-hydroxytryptophan (5-HTP) could correct deficits in serotonin production and brain bioenergetics associated with depression in women, yielding synergistic benefit. We describe an open-label study of 5-HTP and creatine augmentation in women with MDD who had failed selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) monotherapy...
August 5, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28922379/elevating-serotonin-pre-partum-alters-the-holstein-dairy-cow-hepatic-adaptation-to-lactation
#5
Samantha R Weaver, Allan S Prichard, Noah L Maerz, Austin P Prichard, Elizabeth L Endres, Lorenzo E Hernández-Castellano, Matthew S Akins, Rupert M Bruckmaier, Laura L Hernandez
Serotonin is known to regulate energy and calcium homeostasis in several mammalian species. The objective of this study was to determine if pre-partum infusions of 5-hydroxytryptophan (5-HTP), the immediate precursor to serotonin synthesis, could modulate energy homeostasis at the level of the hepatocyte in post-partum Holstein and Jersey dairy cows. Twelve multiparous Holstein cows and twelve multiparous Jersey cows were intravenously infused daily for approximately 7 d pre-partum with either saline or 1 mg/kg bodyweight of 5-HTP...
2017: PloS One
https://www.readbyqxmd.com/read/28911622/sedative-and-hypnotic-effects-of-supercritical-carbon-dioxide-fluid-extraction-from-schisandra-chinensis-in-mice
#6
Hongyan Zhu, Lina Zhang, Guoli Wang, Zhongmei He, Yan Zhao, Yonghua Xu, Yugang Gao, Lianxue Zhang
Schisandra chinensis is a traditional Chinese medicine that has been used for treating insomnia and neurasthenia for centuries. Lignans, which are considered to be the bioactive components, are apt to be extracted by supercritical carbon dioxide. This study was conducted to investigate the sedative and hypnotic activities of the supercritical carbon dioxide fluid extraction of S. chinensis (SFES) in mice and the possible mechanisms. SFES exhibited an obvious sedative effect on shortening the locomotor activity in mice in a dose-dependent (10-200 mg/kg) manner...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28888448/effect-of-explosion-puffed-coffee-on-locomotor-activity-and-behavioral-patterns-in-drosophila-melanogaster
#7
Bong Soo Ko, So Hyun Ahn, Dong Ouk Noh, Ki-Bae Hong, Sung Hee Han, Hyung Joo Suh
We hypothesized that the administration of explosion-puffed coffee, containing γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP), would be associated with a reduction of the caffeine effect on sleep behavior and behavioral patterns, which was investigated in a Drosophila model. The effects of feeding roasted coffee beans (RB), explosion-puffed coffee beans puffed at 0.75MPa and 0.9MPa (PB 7.5 and PB 9.0, respectively), or decaffeinated coffee beans (DeRB) on locomotor activity and behavioral patterns of Drosophila was analyzed...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28751068/dopa-decarboxylase-modulates-tau-toxicity
#8
Rebecca L Kow, Carl Sikkema, Jeanna M Wheeler, Charles W Wilkinson, Brian C Kraemer
BACKGROUND: The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D2-family dopamine receptors ameliorated tauopathy in multiple models including a Caenorhabditis elegans model of tauopathy. METHODS: To better understand how loss of D2-family dopamine receptors can ameliorate tau toxicity, we screened a collection of C. elegans mutations in dopamine-related genes (n = 45) for changes in tau transgene-induced behavioral defects...
June 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28745143/high-fat-simple-carbohydrate-hfsc-diet-impairs-hypothalamic-and-corpus-striatal-serotonergic-metabolic-pathway-in-metabolic-syndrome-mets-induced-c57bl-6j-mice
#9
DSouza Serena Stephen, Asha Abraham
OBJECTIVES: To study the effect of specially formulated high-fat simple carbohydrate diet (HFSC) on the serotonin metabolic pathway in male C57BL/6J mice. METHODS: Previous studies from our laboratory have shown that specially formulated HFSC induces metabolic syndrome in C57BL/6J mice. In the present investigation, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid were analyzed in two brain regions (hypothalamus, corpus striatum), urine and plasma of HFSC-fed mice on a monthly basis up to 5 months using high-performance liquid chromatography fitted with electrochemical detector...
July 26, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28686023/phoxi-a-high-quantum-yield-solvent-sensitive-blue-fluorescent-5-hydroxytryptophan-derivative-synthesized-within-ten-minutes-under-aqueous-ambient-conditions
#10
Alexandre Grigoryan, Azaria S Eisenberg, Laura J Juszczak
Multiple tryptophan (Trp) proteins are not amenable to fluorescence study because individual residue emission is not resolvable. Biosynthetic incorporation of an indole analogue such as 5-hydroxyindole has not provided sufficient spectroscopic resolution because of low quantum yield and small emission shift. Here, 5-hydroxyindole is used as the starting framework for building a blue emitting fluorophore of high quantum yield, 2-phenyl-6H-oxazolo[4,5-e]indole (PHOXI). This is a three reagent reaction completed in 10 min under ambient conditions in borate buffer at pH 8...
August 3, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28642233/sembragiline-a-novel-selective-monoamine-oxidase-type-b-inhibitor-for-the-treatment-of-alzheimer-s-disease
#11
Edilio Borroni, Bernd Bohrmann, Fiona Grueninger, Eric Prinssen, Stephane Nave, Hansruedi Loetscher, Shankar J Chinta, Subramanian Rajagopalan, Anand Rane, Almas Siddiqui, Bart Ellenbroek, Juerg Messer, Axel Pähler, Julie K Andersen, Rene Wyler, Andrea M Cesura
Monoamine oxidase B (MAO-B) has been implicated in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. Increased MAO-B expression in astroglia has been observed adjacent to amyloid plaques in AD patient brains. This phenomenon is hypothesized to lead to increased production of hydrogen peroxide and reactive oxygen species (ROS), thereby contributing to AD pathology. Therefore, reduction of ROS-induced oxidative stress via inhibition of MAO-B activity may delay the progression of the disease...
September 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28601766/trace-level-determination-of-5-hydroxytryptamine-and-its-related-indoles-in-amniotic-fluid-by-gas-chromatography-mass-spectrometry
#12
Hongmei Shi, Bo Wang, Lingmei Niu, Mengsi Cao, Weijun Kang, Kaoqi Lian, Pingping Zhang
5-hydroxytryptamine (5-HT) and its derivatives are endogenously active substances involved in multiple physiological and pathological processes. A novel method of detetermining 5-hydroxyindole ethanol (5-HTOL), 5-hydroxyindole acetic acid (5-HIAA), 5-hydroxytryptophan (5-HTP) and 5-HT in amniotic fluid by gas chromatography-mass spectrometry (GC-MS) was established based on a modified method of derivatization by silanization, in combination with solid-phase extraction pretreatment. Good linearity was achieved in the tested calibration range...
September 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28577106/effect-of-stimulation-of-neurotransmitter-systems-on-heart-rate-variability-and-%C3%AE-adrenergic-responsiveness-of-erythrocytes-in-outbred-rats
#13
E V Kur'yanova, A V Tryasuchev, V O Stupin, D L Teplyi
We studied heart rate variability and β-adrenergic responsiveness of erythrocytes and changes in these parameters in response to single administration of β-adrenoblocker propranolol (2 mg/kg) in outbred male rats against the background of activation of the noradrenergic, serotonergic, and dopaminergic neurotransmitter systems achieved by 4-fold injections maprotiline (10 mg/kg), 5-hydroxytryptophan (50 mg/kg) combined with fluoxetine (3 mg/kg), and L-DOPA (20 mg/kg) with amantadine (20 mg/kg), respectively...
May 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28566180/improved-strength-on-5-hydroxytryptophan-and-carbidopa-in-spinal-cord-atrophy
#14
Gabriella A Horvath, Lorelyn Meisner, Kathryn Selby, Robert Stowe, Bruce Carleton
There is ample evidence of an important role of descending serotonergic projections in modulating spinal motor neuron activation and firing, and experimental studies suggest that 5-HT receptor stimulation can improve motor function after spinal cord injury; however, relevant clinical data is sorely lacking. We describe two sisters with hemiplegic migraine, low CSF and platelet serotonin levels, and progressive spastic paraparesis associated with profound spinal cord atrophy whose lower extremity strength and ambulation responded to a precursor replacement strategy (5-hydroxytryptophan and carbidopa administration), an approach that may have broader applicability in myelopathies of diverse etiology where descending serotonergic projections are compromised...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28502117/passive-membrane-penetration-of-the-serotonin-precursor-5-hydroxytryptophan-is-controlled-by-its-zwitterion
#15
Károly Mazák, Béla Noszál
Species-specific partition coefficients in the octanol/water system were determined for the neurotransmitter serotonin (5-HT) and its precursor 5-hydroxytryptophan (5-HTP). The pH-independent partition coefficients (p) of the individual microspecies were determined by combination of experimentally measured distribution constants and a custom-tailored evaluation method, using highly similar auxiliary compounds. Experimental microscopic partition coefficients for triprotic molecules have only been reported before for thyroxine and its derivatives...
August 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28456683/patchouli-alcohol-ameliorates-dextran-sodium-sulfate-induced-experimental-colitis-and-suppresses-tryptophan-catabolism
#16
Chang Qu, Zhong-Wen Yuan, Xiu-Ting Yu, Yan-Feng Huang, Guang-Hua Yang, Jian-Nan Chen, Xiao-Ping Lai, Zi-Ren Su, Hui-Fang Zeng, Ying Xie, Xiao-Jun Zhang
Despite the increased morbidity of ulcerative colitis (UC) in recent years, available treatments remain unsatisfactory. Pogostemon cablin has been widely applied to treat a variety of gastrointestinal disorders in clinic for centuries, in which patchouli alcohol (PA, C15H26O) has been identified as the major active component. This study attempted to determine the bioactivity of PA on dextran sulfate sodium (DSS)-induced mice colitis and clarify the mechanism of action. Acute colitis was induced in mice by 3% DSS for 7 days...
April 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28442351/major-depressive-disorder-mediates-accelerated-aging-in-rats-subjected-to-chronic-mild-stress
#17
Xiaoxian Xie, Yangyang Chen, Lingyan Ma, Qichen Shen, Liangfeng Huang, Binggong Zhao, Tao Wu, Zhengwei Fu
Major depressive disorder (MDD) has a complex etiology and is characterized by a change in mood and psychophysiological state. MDD has been shown to mediate accelerated biological aging in patients, although the underlying mechanism is not well understood. In the present study, we used a chronic mild stress (CMS) paradigm to induce anhedonia, one of the main symptoms of MDD. CMS induced depression-like symptoms in rats, including reduced sucrose preference and increased immobility time in the forced swim test...
June 30, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28413824/perturbation-of-serotonin-homeostasis-during-adulthood-affects-serotonergic-neuronal-circuitry
#18
Marta Pratelli, Sara Migliarini, Barbara Pelosi, Francesco Napolitano, Alessandro Usiello, Massimo Pasqualetti
Growing evidence shows that the neurotransmitter serotonin (5-HT) modulates the fine-tuning of neuron development and the establishment of wiring patterns in the brain. However, whether serotonin is involved in the maintenance of neuronal circuitry in the adult brain remains elusive. Here, we use a Tph2(fl)°(x) conditional knockout (cKO) mouse line to assess the impact of serotonin depletion during adulthood on serotonergic system organization. Data show that the density of serotonergic fibers is increased in the hippocampus and decreased in the thalamic paraventricular nucleus (PVN) as a consequence of brain serotonin depletion...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28413401/parkinsonism-in-association-with-dihydropteridine-reductase-deficiency
#19
Yoshiaki Takahashi, Yasuhiro Manabe, Yumiko Nakano, Taijun Yunoki, Syoichiro Kono, Hisashi Narai, Mahoko Furujo, Koji Abe
We report a 16-year-old man with disorders of tetrahydrobiopterin metabolism due to dihydropteridine reductase (DHPR) deficiency. He revealed moderate mental retardation, parkinsonism, and spastic paralysis with levodopa and 5-hydroxytryptophan (5-HTP) supplementation from the age of 2 months. Brain MRI showed high intensity areas in bilateral frontal and posterior deep white matter on fluid-attenuated inversion recovery (FLAIR). Coronal FLAIR image showed a high signal in bilateral pyramidal tracts. Single photon computed tomography (SPECT) imaging of the dopamine transporter was normal...
January 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28406734/effects-of-trang-phuc-linh-plus-food-supplement-on-irritable-bowel-syndrome-induced-by-mustard-oil
#20
Thong T Nguyen, Duong T Dau, Dung C Nguyen, Huong T T G Nguyen, Phuong T B Ngo, Thai Q Nguyen, Bo Han, Ba X Hoang
Trang phuc linh plus (TPLP) is a food supplement product derived from dried extracts of herbal agents Atractylodes macrocephala, Poria cocos, Paeonia lactiflora, Phellodendron amurense, and added lactobacillus fermentum lysate (ImmuneGamma(®)) and 5-hydroxytryptophan. TPLP is a functional food used as adjunctive treatment for treating irritable bowel syndrome (IBS). However the biological effect and its mechanism of action in IBS have not been elucidated. In this study, we aimed to determine the pharmacological activities and mode of action of TPLP on IBS animal models...
April 2017: Journal of Medicinal Food
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