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https://www.readbyqxmd.com/read/29676067/significance-of-skin-barrier-dysfunction-in-atopic-dermatitis
#1
REVIEW
Byung Eui Kim, Donald Y M Leung
The epidermis contains epithelial cells, immune cells, and microbes which provides a physical and functional barrier to the protection of human skin. It plays critical roles in preventing environmental allergen penetration into the human body and responsing to microbial pathogens. Atopic dermatitis (AD) is the most common, complex chronic inflammatory skin disease. Skin barrier dysfunction is the initial step in the development of AD. Multiple factors, including immune dysregulation, filaggrin mutations, deficiency of antimicrobial peptides, and skin dysbiosis contribute to skin barrier defects...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675776/pluripotent-stem-cells-for-retinal-tissue-engineering-current-status-and-future-prospects
#2
REVIEW
Ratnesh Singh, Oscar Cuzzani, François Binette, Hal Sternberg, Michael D West, Igor O Nasonkin
The retina is a very fine and layered neural tissue, which vitally depends on the preservation of cells, structure, connectivity and vasculature to maintain vision. There is an urgent need to find technical and biological solutions to major challenges associated with functional replacement of retinal cells. The major unmet challenges include generating sufficient numbers of specific cell types, achieving functional integration of transplanted cells, especially photoreceptors, and surgical delivery of retinal cells or tissue without triggering immune responses, inflammation and/or remodeling...
April 19, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29675492/endometrial-mesenchymal-stem-stromal-cells-in-mature-and-immature-sheep-an-in-vitro-study
#3
Farnaz Ghobadi, Farhad Rahmanifar, Davood Mehrabani, Amin Tamadon, Mehdi Dianatpour, Shahrokh Zare, Iman Razeghian Jahromi
Background: Endometrial mesenchymal stem stromal cells (EnMSCs) are critical for uterine function, repair, and regeneration. Objective: This study introduced isolation technique of EnMSCs and compared the characteristics of EnMSCs in mature and immature ewes. Materials and Methods: Endometrial tissue samples from the uterus of 10 ewes were collected from the slaughterhouse. Endometrial cells were isolated from tissue using cold incubation and then chopping and treating was performed with collagenase type I...
February 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29674798/switching-of-antihypertensive-drugs-at-tertiary-care-government-hospital-hyderabad-india-a-cross-sectional-retrospective-investigation
#4
Varsha Varakantham, Ashok Kumar Kurakula Sailoo, Venkaiah Kodali, Dinesh Kumar Bharatraj
OBJECTIVE: Switching of antihypertensive drugs is attributed to uncontrolled blood pressure (BP) which imposes a great burden on health economics. But again, switching leads to accomplishment of the goal BP, thereby improving the health status. Such studies are well documented in developed nations but rarely reported in developing countries, especially in India. Therefore, the aim of this study was to evaluate various factors associated with switching of antihypertensive drugs. METHODS: A cross-sectional retrospective investigation was performed using a standardized schedule adapting the World Health Organization indicators for drug utilization in a tertiary care government hospital, Hyderabad, India...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674791/research-design-the-methodology-for-interdisciplinary-research-framework
#5
Hilde Tobi, Jarl K Kampen
Many of today's global scientific challenges require the joint involvement of researchers from different disciplinary backgrounds (social sciences, environmental sciences, climatology, medicine, etc.). Such interdisciplinary research teams face many challenges resulting from differences in training and scientific culture. Interdisciplinary education programs are required to train truly interdisciplinary scientists with respect to the critical factor skills and competences. For that purpose this paper presents the Methodology for Interdisciplinary Research (MIR) framework...
2018: Quality & Quantity
https://www.readbyqxmd.com/read/29674195/thrombotic-microangiopathies-of-pregnancy-differential-diagnosis
#6
REVIEW
M Gupta, B B Feinberg, R M Burwick
Thrombotic microangiopathy (TMA) disorders are characterized by microangiopathic hemolytic anemia, thrombocytopenia and end-organ injury. In pregnancy and postpartum, TMA is most commonly encountered with HELLP (hemolysis, elevated liver enzymes, low platelet count syndrome) or preeclampsia with severe features, but rarely TMA is due to thrombotic thrombocytopenic purpura (TTP) or atypical hemolytic uremic syndrome (aHUS). Due to overlapping clinical and laboratory features, TTP and aHUS are often mistaken for preeclampsia or HELLP...
February 16, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673565/scanning-the-horizon-for-high-value-add-manufacturing-science-accelerating-manufacturing-readiness-for-the-next-generation-of-disruptive-high-value-curative-cell-therapeutics
#7
Paul Hourd, David J Williams
BACKGROUND: Since the regenerative medicine sector entered the second phase of its development (RegenMed 2.0) more than a decade ago, there is increasing recognition that current technology innovation trajectories will drive the next translational phase toward the production of disruptive, high-value curative cell and gene-based regenerative medicines. AIM: To identify the manufacturing science problems that must be addressed to permit translation of these next generation therapeutics...
April 16, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29673485/functional-brain-networks-are-dominated-by-stable-group-and-individual-factors-not-cognitive-or-daily-variation
#8
Caterina Gratton, Timothy O Laumann, Ashley N Nielsen, Deanna J Greene, Evan M Gordon, Adrian W Gilmore, Steven M Nelson, Rebecca S Coalson, Abraham Z Snyder, Bradley L Schlaggar, Nico U F Dosenbach, Steven E Petersen
The organization of human brain networks can be measured by capturing correlated brain activity with fMRI. There is considerable interest in understanding how brain networks vary across individuals or neuropsychiatric populations or are altered during the performance of specific behaviors. However, the plausibility and validity of such measurements is dependent on the extent to which functional networks are stable over time or are state dependent. We analyzed data from nine high-quality, highly sampled individuals to parse the magnitude and anatomical distribution of network variability across subjects, sessions, and tasks...
April 18, 2018: Neuron
https://www.readbyqxmd.com/read/29672923/dual-role-of-par-4-in-abrogation-of-emt-and-switching-on-mesenchymal-to-epithelial-transition-met-in-metastatic-pancreatic-cancer-cells
#9
Archana Katoch, Sujit Suklabaidya, Souneek Chakraborty, Debasis Nayak, Reyaz Ur Rasool, Deepak Sharma, Debaraj Mukherjee, Mir Mohd Faheem, Anmol Kumar, Parduman Raj Sharma, Shantibhusan Senapati, Lekha Dinesh Kumar, Anindya Goswami
Epithelial-mesenchymal transition (EMT), a critical event that occurs during invasion and metastatic spread of cancer cells. Here, we conceive a dual mechanism of Par-4-mediated inhibition of EMT and induction of MET in metastatic pancreatic cancer cells. First, we demonstrate that 1,1'-β-D-glucopyranosyl-3,3'-bis(5-bromoindolyl)-octyl methane (NGD16), an N-glycosylated derivative of medicinally important phytochemical 3,3'-diindolylmethane (DIM) abrogates EMT by inducing pro-apoptotic protein Par-4. Induction of Par-4 (by NGD16 or ectopic overexpression) strongly impedes invasion with inhibition of major mesenchymal markers viz...
April 19, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29672356/improving-documentation-of-inpatient-problem-list-in-electronic-health-record-a-quality-improvement-project
#10
Prabi Rajbhandari, Moises Auron, Sarah Worley, Michelle Marks
BACKGROUND: The problem list is critical in electronic documentation. It is a powerful tool for clinical decision-making because it provides a concise view of all patient problems in one place and is also a criterion for the Medicare meaningful use incentive program. OBJECTIVE: To measure the rate of utilization of problem list in electronic health records (EHR) in a pediatric hospital medicine unit and implement sequential interventions to increase the rate of use of problem list to more than 80% by the end of 2015, as measured by at least one documented hospital problem at discharge...
April 19, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29671630/the-critical-role-of-epigallocatechin-gallate-in-regulating-mitochondrial-metabolism
#11
Weimei Shi, Linfu Li, Yechun Ding, Kai Yang, Zhixi Chen, Xiaona Fan, Shan Jiang, Yingjie Guan, Zhiping Liu, Daohua Xu, Longhuo Wu
Epigallocatechin gallate (EGCG), one of polyphenols isolated from green tea, exhibits biology-benefiting effects with minimum severe adverse. EGCG is known to be a mitochondrion-targeting medicinal agent, regulating mitochondrial metabolism, including mitochondrial biogenesis, mitochondrial bioenergetics, and mitochondria-mediated cell cycle and apoptosis. EGCG might exhibit either antioxidative activity to prevent against oxidative stress or pro-oxidative activity to counteract cancer cells, which depends on the cellular stress situations, cell types and the concentration of EGCG...
April 19, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29671356/extracellular-vesicles-pathogenetic-diagnostic-and-therapeutic-value-in-traumatic-brain-injury
#12
Stefania Mondello, Eric P Thelin, Gerry Shaw, Michelle Salzet, Carmela Visalli, Dasa Cizkova, Firas Kobeissy, Andras Buki
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Accurate classification according to injury-specific and patient-specific characteristics is critical to help informed clinical decision-making and to the pursuit of precision medicine in TBI. Reliable biomarker signatures for improved TBI diagnostics are required but still an unmet need. Areas covered: Extracellular vesicles (EVs) represent a new class of biomarker candidates in TBI. These nano-sized vesicles have key roles in cell signaling profoundly impacting pathogenic pathways, progression and long-term sequelae of TBI...
April 19, 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29671037/-geriatric-intensive-care-patients-perspectives-and-limits-of-geriatric-intensive-care-medicine
#13
REVIEW
U Müller-Werdan, H-J Heppner, G Michels
Critically ill geriatric patients are vitally endangered due to the aging processes of organs, the frequently existing multimorbidity with subsequent polypharmacy and the typical geriatric syndrome of functional impairments. Aging processes in organs lower the clinical threshold for organ dysfunction and organ failure. Physiological organ aging processes with practical consequences for intensive care medicine are atypical manifestion of sepsis in immunosenescence, altered pharmacokinetics, reduced tolerance to hypovolemia due to proportionally reduced water compartment of the body in old age, the frequently only apparently normal function of the kidneys and the continuous reduction in pulmonary function in old age...
April 18, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29670200/effectiveness-of-traditional-chinese-medicineas-as-an-adjunct-therapy-for-refractory-schizophrenia-a-systematic-review-and-meta-analysis
#14
Yan-Yan Wei, Wan-Fu Lin, Tian-Hong Zhang, Yun-Xiang Tang, Ji-Jun Wang, Mao-Feng Zhong
Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-analysis to investigate the effectiveness of TCM in combination with antipsychotics for refractory schizophrenia. Fourteen articles involving 1725 patients published as of December 2016 were included which compared antipsychotic therapies to either TCM alone, or TCM as an adjunctive therapy...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669430/providing-palliative-care-in-the-medical-icu-a-qualitative-study-of-micu-physicians-beliefs-and-practices
#15
Brittany Gatta, Jessica Turnbull
CONTEXT: With the current and projected shortage of palliative care (PC) specialists, an integrative model of PC will be needed to meet the needs of patients in intensive care units (ICUs). Prior studies of PC interventions suggest that success depends upon meeting the needs of individual institutions or ICUs. OBJECTIVE: The objective of this study was to qualitatively explore the beliefs and practices of one institution's medical ICU (MICU) physicians in regard to providing an integrative model of PC...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29669165/the-state-of-survivorship-care-in-radiation-oncology-results-from-a-nationally-distributed-survey
#16
Melissa A Frick, Seth A Rosenthal, Neha Vapiwala, Brian T Monzon, Abigail T Berman
BACKGROUND: Survivorship care has become an increasingly critical component of oncologic care as well as a quality practice and reimbursement metric. To the authors' knowledge, the current climate of survivorship medicine in radiation oncology has not been investigated fully. METHODS: An institutional review board-approved, Internet-based survey examining practices and preparedness in survivorship care was distributed to radiation oncology practices participating in the American College of Radiology Radiation Oncology Practice Accreditation program between November 2016 and January 2017...
April 18, 2018: Cancer
https://www.readbyqxmd.com/read/29669065/translational-behavioral-medicine-for-population-and-individual-health-gaps-opportunities-and-vision-for-practice-based-translational-behavior-change-research
#17
Jun Ma, Megan A Lewis, Joshua M Smyth
In this commentary, we propose a vision for "practice-based translational behavior change research," which we define as clinical and public health practice-embedded research on the implementation, optimization, and fundamental mechanisms of behavioral interventions. This vision intends to be inclusive of important research elements for behavioral intervention development, testing, and implementation. We discuss important research gaps and conceptual and methodological advances in three key areas along the discovery (development) to delivery (implementation) continuum of evidence-based interventions to improve behavior and health that could help achieve our vision of practice-based translational behavior change research...
April 12, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29669017/the-transmutation-of-deference-in-medicine-an-ethico-legal-perspective
#18
Sarah Devaney, Søren Holm
This article critically considers the question of whether an increase in legal recognition of patient autonomy culminating in the decision of the Supreme Court in Montgomery v Lanarkshire Health Board in 2015 has led to the death of deference to doctors, not only within the courts and healthcare regulatory arenas in England and Wales but also in the consulting room and the health care system more broadly. We argue that deference has not been eradicated, but that the types of deference paid to doctors and to the medical profession have changed...
April 12, 2018: Medical Law Review
https://www.readbyqxmd.com/read/29668803/the-potential-contribution-of-the-natural-products-from-brazilian-biodiversity-to-bioeconomy
#19
Marilia Valli, Helena M Russo, Vanderlan S Bolzani
The development of our society has been based on the use of biodiversity, especially for medicines and nutrition. Brazil is the nation with the largest biodiversity in the world accounting for more than 15% of all living species. The devastation of biodiversity in Brazil is critical and may not only cause the loss of species and genes that encode enzymes involved in the complex metabolism of organisms, but also the loss of a rich chemical diversity, which is a potential source for bioeconomy based on natural products and new synthetic derivatives...
April 16, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29668075/a-comparison-of-debate-and-role-play-in-enhancing-critical-thinking-and-communication-skills-of-medical-students-during-problem-based-learning
#20
Rabia Latif, Sadaf Mumtaz, Rafia Mumtaz, Aamir Hussain
Debate and role play for learning critical thinking and communication skills are being increasingly used in various undergraduate medical schools worldwide. We aim to compare students' views about effectiveness of two teaching strategies; debate and role play to exercise critical thinking and communication skills during problem-based learning (PBL). This is a comparative, cross-sectional, and questionnaire-based study. Our subjects were second year undergraduate female medical students enrolled in Imam Abdulrahman Bin Faisal University (IAU), College of Medicine from September 2014-2016, divided into 10 small PBL groups (10-13 students/group/year)...
April 18, 2018: Biochemistry and Molecular Biology Education
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