Takaaki Tsuboi, Tomohiko Matsuzaki, Susumu Takekoshi, Kei Nakano, Kie Shioyama, Tomoki Higeta, Kazuhiro Matsuo, Takashi Ishihara, Masaya Ohara, Kenei Nakazato, Ryota Masuda, Masayuki Iwazaki
In epithelial tissues, intercellular adhesion structures are formed between adjacent cells via intercellular adhesion factors, such as zonula occludens (ZO-1), to maintain the structure and function of tissues and organs, thereby contributing to homeostasis. Epithelial cells are polarized into apical and basal regions by tight junctions (TJs), a type of intercellular adhesion structure, and thus, their intracellular organelles are asymmetrically distributed. Normal epithelial cells maintain their cellular function by controlling cytoskeletal reorganization, motility, and division by maintaining asymmetry in their intracellular organelles...
April 20, 2024: Tokai Journal of Experimental and Clinical Medicine