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https://www.readbyqxmd.com/read/28820712/scrub-typhus-as-an-etiology-of-acute-febrile-illness-in-gorakhpur-uttar-pradesh-india-2016
#1
Jeromie Wesley Vivian Thangraj, Mahima Mittal, Valsan Philip Verghese, C P Girish Kumar, Winsley Rose, R Sabarinathan, Ashok Kumar Pandey, Nivedita Gupta, Manoj Murhekar
Seasonal outbreaks of acute encephalitis syndrome (AES) with high mortality occur every year in Gorakhpur region of Uttar Pradesh, India. Earlier studies indicated the role of scrub typhus as the important etiology of AES in the region. AES cases were hospitalized late in the course of their illness. We established surveillance for acute febrile illness (AFI) (fever ≥ 4 days duration) in peripheral health facilities in Gorakhpur district to understand the relative contribution of scrub typhus. Of the 224 patients enrolled during the 3-month period corresponding to the peak of AES cases in the region, about one-fifth had immunoglobulin M (IgM) antibodies against Orientia tsutsugamushi...
August 14, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28763150/pneumonia-in-the-tropics
#2
REVIEW
Tow Keang Lim, Wen Ting Siow
Pneumonia in the tropics poses a heavy disease burden. The complex interplay of climate change, human migration influences and socio-economic factors lead to changing patterns of respiratory infections in tropical climate but also increasingly in temperate countries. Tropical and poorer countries, especially South East Asia, also bear the brunt of the global tuberculosis (TB) pandemic, accounting for almost one-third of the burden. But, as human migration patterns evolve, we expect to see more TB cases in higher income as well as temperate countries, and rise in infections like scrub typhus from ecotourism activities...
August 1, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28386493/dengue-and-scrub-typhus-coinfection-in-a-patient-presenting-with-febrile-illness
#3
Surendra Sapkota, Sudeep Bhandari, Subash Sapkota, Rabin Hamal
Dengue fever and scrub typhus are common causes of acute febrile illness of unclear origin in Asia. Though coinfections of many vector-borne diseases have been described, articles on dengue and scrub typhus coinfection are distinctly limited. In case of coinfection with dengue and scrub typhus, vigilant monitoring of vitals, platelets transfusion, and timely treatment with doxycycline are necessary. High degree of suspicion has to be made for coinfection in a patient presenting with febrile illness with thrombocytopenia and deranged laboratory parameters in postmonsoon season in endemic regions in Asia...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28250620/clinical-score-to-differentiate-scrub-typhus-and-dengue-a-tool-to-differentiate-scrub-typhus-and-dengue
#4
Shubhanker Mitra, Ira Gautam, Mohan Jambugulam, Kundavaram Paul Prabhakar Abhilash, Vishalakshi Jayaseeelan
BACKGROUND: Dengue and scrub typhus share similar clinical and epidemiological features, and are difficult to differentiate at initial presentation. Many places are endemic to both these infections where they comprise the majority of acute undifferentiated febrile illnesses. MATERIALS AND METHODS: We aimed to develop a score that can differentiate scrub typhus from dengue. In this cross-sectional study, 188 cases of scrub typhus and 201 cases of dengue infection who presented to the emergency department or medicine outpatient clinic from September 2012 to April 2013 were included...
January 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28144059/epidemiological-profile-of-acute-respiratory-distress-syndrome-patients-a-tertiary-care-experience
#5
Rahul Magazine, Shobitha Rao, Bharti Chogtu, Ramkumar Venkateswaran, Hameed Aboobackar Shahul, Umesh Goneppanavar
BACKGROUND: Acute respiratory distress syndrome (ARDS) is seen in critically ill patients. Its etiological spectrum in India is expected to be different from that seen in western countries due to the high prevalence of tropical infections. AIM: To study the epidemiological profile of ARDS patients. SETTING: A tertiary care hospital in Karnataka, India. MATERIALS AND METHODS: Retrospective analysis of 150 out of the 169 ARDS patients diagnosed during 2010-2012...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28088326/acute-kidney-injury-due-to-tropical-infectious-diseases-and-animal-venoms-a-tale-of-2-continents
#6
REVIEW
Emmanuel A Burdmann, Vivekanand Jha
South and Southeast Asia and Latin American together comprise 46 countries and are home to approximately 40% of the world population. The sociopolitical and economic heterogeneity, tropical climate, and malady transitions characteristic of the region strongly influence disease behavior and health care delivery. Acute kidney injury epidemiology mirrors these inequalities. In addition to hospital-acquired acute kidney injury in tertiary care centers, these countries face a large preventable burden of community-acquired acute kidney injury secondary to tropical infectious diseases or animal venoms, affecting previously healthy young individuals...
January 11, 2017: Kidney International
https://www.readbyqxmd.com/read/27942194/acute-undifferentiated-febrile-illness-in-patients-presenting-to-a-tertiary-care-hospital-in-south-india-clinical-spectrum-and-outcome
#7
Kundavaram Paul Prabhakar Abhilash, Jonathan Arul Jeevan, Shubhanker Mitra, Nirvin Paul, Thimiri Palani Murugan, Ajay Rangaraj, Sandeep David, Samuel George Hansdak, John Antony Jude Prakash, Asha Mary Abraham, Prakash Ramasami, Sowmya Sathyendra, Thambu David Sudarsanam, George M Varghese
BACKGROUND: Acute undifferentiated febrile illness (AUFI) may have similar clinical presentation, and the etiology is varied and region specific. MATERIALS AND METHODS: This prospective observational study was conducted in a tertiary hospital in South India. All adult patients presenting with AUFI of 3-14 days duration were evaluated for etiology, and the differences in presentation and outcome were analyzed. RESULTS: The study cohort included 1258 patients...
October 2016: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/27924792/a-cost-effective-approach-to-the-diagnosis-and-management-of-acute-infectious-encephalitis
#8
Usha Kant Misra, Vinita Elizabeth Mani, Jayantee Kalita
SETTING: A tertiary care teaching hospital in India. OBJECTIVE: To report a syndromic approach to acute encephalitis syndrome (AES) and propose a cost-effective model. STUDY DESIGN: AES patients were categorized by the presence or absence of myalgia/rash into systemic and neurological AES. The patients with systemic AES were investigated for dengue, scrub typhus, leptospira, chikungunya, and malaria, and those with neurological AES were investigated for herpes and Japanese encephalitis (JE)...
2017: European Neurology
https://www.readbyqxmd.com/read/27731577/concurrent-infection-with-scrub-typhus-dengue-and-malaria-in-an-immunocompetent-young-male
#9
Meenaxi Sharda, Shivraj Meena, Anil Soni, Harish Nigam, Anuraj Singh
No abstract text is available yet for this article.
March 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27730774/infections-and-thrombocytopenia
#10
EDITORIAL
Falguni Parikh
Febrile patient with thrombocytopenia is commonly encountered by physicians especially during monsoon and perimonsoon period. Infections with protozoa, bacteria and viruses can cause thrombocytopenia with or without disseminated intravascular coagulation. Commonly dengue, malaria, scrub typhus and other rickettsial infections, meningococci, leptospira and certain viral infections present as fever with thrombocytopenia. Occasionally these patients can go on to develop a stormy course with multiorgan dysfunction requiring intensive care unit admission associated with high morbidity and mortality...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27613205/protection-of-military-personnel-against-vector-borne-diseases-a-review-of-collaborative-work-of-the-australian-and-us-military-over-the-last-30-years
#11
Stephen P Frances, Michael D Edstein, Mustapha Debboun, G Dennis Shanks
Australian and US military medical services have collaborated since World War II to minimize vector-borne diseases such as malaria, dengue, and scrub typhus. In this review, collaboration over the last 30 years is discussed. The collaborative projects and exchange scientist programs have resulted in mutually beneficial outcomes in the fields of drug development and personal protection measures against vector-borne diseases.
October 2016: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/27512107/spectrum-and-outcome-of-acute-infectious-encephalitis-encephalopathy-in-an-intensive-care-unit-from-india
#12
J Kalita, V E Mani, S K Bhoi, U K Misra
Purpose: To evaluate the spectrum of acute infectious encephalitis/encephalopathy syndrome (AIES) in intensive care unit (ICU) and the predictors of mechanical ventilation (MV) and outcome of these patients. Methods: AIES patients diagnosed on the basis of fever, altered sensorium, seizure and cerebrospinal fluid pleocytosis admitted to the neurology ICU were prospectively included. The demographic and clinical details, hematological, biochemical, MRI and etiological findings of the patients were noted...
March 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27413521/clinical-and-laboratory-characteristics-of-dengue-orientia-tsutsugamushi-co-infection-from-a-tertiary-care-center-in-south-india
#13
Aneesh Basheer, Nayyar Iqbal, Sudhagar Mookkappan, Patricia Anitha, Shashikala Nair, Reba Kanungo, Ravichandran Kandasamy
BACKGROUND: Concurrent infection with multiple pathogens is common in tropics, posing diagnostic and treatment challenges. Although co-infections of dengue, malaria, leptospirosis and typhoid in various combinations have been described, data on dengue and scrub typhus co-infection is distinctly limited. METHODOLOGY: This study was a retrospective analysis of dengue and scrub typhus co-infection diagnosed between January 2010 and July 2014 at a tertiary care center...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27198211/quantitative-and-volume-conductivity-and-scatter-changes-in-leucocytes-of-patients-with-acute-undifferentiated-febrile-illness-a-pilot-study
#14
Varun Kalra, Sohaib Ahmad, Vikas Shrivastava, Garima Mittal
BACKGROUND: A single diagnostic test for acute undifferentiated febrile illnesses (AUFI) is elusive. This pilot study was undertaken on the premise that leucocytes, being the main cells of defence, undergo quantitative, structural and functional changes in AUFI. We evaluated the potential of volume, conductivity and scatter (VCS) parameters of leucocytes, generated with the haemogram report by the Coulter auto-analyzer, in differentiating the common etiologies of AUFI. METHODS: The haematological and VCS data obtained from 800 controls and 200 cases of AUFI (50 cases each of acute malaria, dengue, scrub typhus and enteric fever) were retrieved for analysis...
May 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27050192/the-aetiologies-and-impact-of-fever-in-pregnant-inpatients-in-vientiane-laos
#15
Vilada Chansamouth, Syvilay Thammasack, Rattanaphone Phetsouvanh, Valy Keoluangkot, Catrin E Moore, Stuart D Blacksell, Josee Castonguay-Vanier, Audrey Dubot-Pérès, Jarasporn Tangkhabuanbutra, Narongchai Tongyoo, Phooksavanh Souphaphonh, Onanong Sengvilaipaseuth, Manivanh Vongsouvath, Koukeo Phommasone, Davanh Sengdethka, Amphayvanh Seurbsanith, Scott B Craig, Laura Hermann, Michel Strobel, Paul N Newton
INTRODUCTION: Laos has the highest maternal mortality ratio in mainland Southeast Asia and a high incidence of infectious diseases. Globally, malaria has been the pathogen most intensively investigated in relation to impact on pregnancy, but there has been relatively little research on the aetiology and impact of other diseases. We therefore aimed to determine the causes and impact of fever in pregnant women admitted to two central hospitals in Vientiane City, Lao PDR (Laos). MATERIALS AND METHODS: This hospital-based prospective study was conducted in Mahosot Hospital and the Mother and Child Hospital, Vientiane, between 2006 and 2010, with the aim to recruit 250 consenting pregnant women admitted with tympanic temperature ≥37...
April 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27027303/modelling-the-impact-and-cost-effectiveness-of-biomarker-tests-as-compared-with-pathogen-specific-diagnostics-in-the-management-of-undifferentiated-fever-in-remote-tropical-settings
#16
Yoel Lubell, Thomas Althaus, Stuart D Blacksell, Daniel H Paris, Mayfong Mayxay, Wirichada Pan-Ngum, Lisa J White, Nicholas P J Day, Paul N Newton
BACKGROUND: Malaria accounts for a small fraction of febrile cases in increasingly large areas of the malaria endemic world. Point-of-care tests to improve the management of non-malarial fevers appropriate for primary care are few, consisting of either diagnostic tests for specific pathogens or testing for biomarkers of host response that indicate whether antibiotics might be required. The impact and cost-effectiveness of these approaches are relatively unexplored and methods to do so are not well-developed...
2016: PloS One
https://www.readbyqxmd.com/read/26943982/ckd-and-infectious-diseases-in-asia-pacific-challenges-and-opportunities
#17
REVIEW
Vivekanand Jha, Narayan Prasad
The exact number of patients with chronic kidney disease (CKD) in Asia Pacific is uncertain. In numeric terms, the region is home to the largest population of patients with untreated chronic kidney failure. The climatic, geographic, social, cultural, economic, and environmental diversity within this region is higher than in any other part of the world. Large parts of the region face a climate-related burden of infectious diseases. Infections contribute to the development and progression of CKD and complicate the course of patients with pre-existing CKD (especially those on dialysis therapy or who are immunosuppressed), increase the cost of CKD care, and contribute to mortality and morbidity...
July 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26851948/a-comparative-hospital-based-observational-study-of-mono-and-co-infections-of-malaria-dengue-virus-and-scrub-typhus-causing-acute-undifferentiated-fever
#18
S Ahmad, M Dhar, G Mittal, N K Bhat, N Shirazi, V Kalra, H C Sati, V Gupta
Positive serology for dengue and/or scrub typhus infection with/without positive malarial smear (designated as mixed or co-infection) is being increasingly observed during epidemics of acute undifferentiated febrile illnesses (AUFIs). We planned to study the clinical and biochemical spectrum of co-infections with Plasmodium sp., dengue virus and scrub typhus and compare these with mono-infection by the same organisms. During the period from December 2012 to December 2013, all cases presenting with AUFIs to a single medical unit of a referral centre in Garhwal region of the north Indian state of Uttarakhand were retrospectively selected and categorised aetiologically as co-infections, malaria, dengue or scrub typhus...
April 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/26816892/aetiologies-of-acute-undifferentiated-febrile-illness-in-adult-patients-an-experience-from-a-tertiary-care-hospital-in-northern-india
#19
Garima Mittal, Sohaib Ahmad, R K Agarwal, Minakshi Dhar, Manish Mittal, Shiwani Sharma
INTRODUCTION: Acute undifferentiated febrile illness (AUFI) is a common clinical entity in most of the hospitals. The fever can be potentially fatal if the aetiology is not recognized and appropriately treated early. AIM: To describe the aetiology of fever among patients in a tertiary care hospital in Northern India. MATERIALS AND METHODS: A one-year retro-prospective, observational study was conducted in adults (age>18years) presenting with undifferentiated febrile illness (of duration 5-14 days)...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26261776/severe-scrub-typhus-infection-clinical-features-diagnostic-challenges-and-management
#20
REVIEW
John Victor Peter, Thomas I Sudarsan, John Anthony J Prakash, George M Varghese
Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis...
August 4, 2015: World Journal of Critical Care Medicine
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