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https://www.readbyqxmd.com/read/28822010/vitrification-of-human-immature-oocytes-before-and-after-in-vitro-maturation-a-review
#1
REVIEW
Mohammad Ali Khalili, Abbas Shahedi, Sareh Ashourzadeh, Stefania Annarita Nottola, Guido Macchiarelli, Maria Grazia Palmerini
The use of immature oocytes subjected to in vitro maturation (IVM) opens interesting perspectives for fertility preservation where ovarian reserves are damaged by pathologies or therapies, as in PCO/PCOS and cancer patients. Human oocyte cryopreservation may offer some advantages compared to embryo freezing, such as fertility preservation in women at risk of losing fertility due to oncological treatment or chronic disease, egg donation and postponing childbirth. It also eliminates religious and/or other ethical, legal, and moral concerns of embryo freezing...
August 18, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28810517/argan-oil-reduces-oxidative-stress-genetic-damage-and-emperipolesis-in-rats-treated-with-acrylamide
#2
Zülal Atlı Şekeroğlu, Birsen Aydın, Vedat Şekeroğlu
Acrylamide (AA), a well-known toxicant, is present in high-temperature-processed foods in heated foods. Argan oil (AO), a natural vegetable oil, is receiving increasing attention due to its powerful biological properties. However, limited information is available about its effects in lymphoid organs and bone marrow. The aim of this study is to investigate the effects of AO on hematological parameters, 8-hydroxydeoxyguanosine (8-OHdG), thiobarbituric acid reactive substances (TBARs), protein carbonyl (PCO), glutathione (GSH), myeloperoxidase (MPO) levels, the formation of micronucleus (MN) and megakaryocytic emperipolesis (ME) against AA-induced toxicity in rats...
August 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28808563/conceptualizing-ecosystem-tipping-points-within-a-physiological-framework
#3
Christopher D G Harley, Sean D Connell, Zoë A Doubleday, Brendan Kelaher, Bayden D Russell, Gianluca Sarà, Brian Helmuth
Connecting the nonlinear and often counterintuitive physiological effects of multiple environmental drivers to the emergent impacts on ecosystems is a fundamental challenge. Unfortunately, the disconnect between the way "stressors" (e.g., warming) is considered in organismal (physiological) and ecological (community) contexts continues to hamper progress. Environmental drivers typically elicit biphasic physiological responses, where performance declines at levels above and below some optimum. It is also well understood that species exhibit highly variable response surfaces to these changes so that the optimum level of any environmental driver can vary among interacting species...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28804235/management-of-varicose-veins-and-chronic-venous-insufficiency-in-a-comparative-registry-with-nine-venoactive-products-in-comparison-with-stockings
#4
G Belcaro, M Dugall, R Luzzi, M Corsi, A Ledda, A Ricci, L Pellegrini, M R Cesarone, M Hosoi, B M Errichi, U Cornelli, R Cotellese, G Agus, B Feragalli
The aim of this registry study was to compare products used to control symptoms of CVI. Endpoints of the study were microcirculation, effects on volume changes, and symptoms (analogue scale). Pycnogenol, venoruton, troxerutin, the complex diosmin-hesperidin, Antistax, Mirtoselect (bilberry), escin, and the combination Venoruton-Pycnogenol (VE-PY) were compared with compressions. No safety or tolerability problems were observed. At inclusion, measurements in the groups were comparable: 1,051 patients completed the registry...
September 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28803418/clinical-results-after-microincision-biaxial-cataract-surgery-and-implantation-of-an-incise-intraocular-lens
#5
Wojciech Lubiński, Marta Kirkiewicz, Karolina Podborączyńska-Jodko
PURPOSE: To evaluate clinical outcomes after uncomplicated microincision biaxial cataract surgery and implantation of Incise intraocular lens (IOL). METHODS: This study included 47 eyes of 29 patients (mean age 62.2 ± 8.6 years), who underwent 1.4-mm biaxial cataract surgery with implantation of the Incise IOL (Bausch and Lomb). At third month, surgically induced astigmatism (SIA) was calculated. Three, 6 and 12 months postoperatively, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), corrected near visual acuity (CNVA) LogMAR ETDRS, spherical equivalent refraction (SER), photopic distance corrected contrast sensitivity (CS) with and without glare (85 cd/m(2)) (CSV-1000) were assessed...
August 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28792434/collective-migration-of-lens-epithelial-cell-induced-by-differential-microscale-groove-patterns
#6
Chunga Kwon, Youngjun Kim, Hojeong Jeon
Herein, a micro-patterned cell adhesive surface is prepared for the future design of medical devices. One-dimensional polydimethylsiloxane (PDMS) micro patterns were prepared by a photolithography process. We investigated the effect of microscale topographical patterned surfaces on decreasing the collective cell migration rate. PDMS substrates were prepared through soft lithography using Si molds fabricated by photolithography. Afterwards, we observed the collective cell migration of human lens epithelial cells (B-3) on various groove/ridge patterns and evaluated the migration rate to determine the pattern most effective in slowing down the cell sheet spreading speed...
August 9, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28766353/the-significance-of-akt-nf-%C3%AE%C2%BAb-signaling-pathway-in-the-posterior-cataract-animal-model
#7
D W Shao, X Q Zhu, L Huo, W Sun, P Pan, W Chen, H Wang, B Liu
OBJECTIVE: To establish SD rat posterior capsular opacification (posterior capsular opacification- PCO) animal model, and to detect the expression of Akt/NF-kb signaling pathway in the PCO model. METHODS: 30 healthy SD rats were randomly divided into control group (0d) and the experimental groups (7d and 14 d), there were 10 rats at all time points. All rats (right eye) were treated with the lens capsule, and the inflammatory reaction of the anterior segment of the eye and the occurrence of PCO at different time points were observed under the microscope...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28765922/electric-field-exposure-promotes-epithelial%C3%A2-mesenchymal-transition-in-human-lens-epithelial-cells-via-integrin-%C3%AE-1%C3%A2-fak-signaling
#8
Jun Liu, Xiao-Long Yan, Xiao-Liang Zheng, Lin Mei, Song Wang, Jing Han, Hong Yan
Electric field (EF) exposure can affect the elongation, migration, orientation, and division of cells. The present study tested the hypothesis that EF may also affect epithelial‑mesenchymal transition (EMT) in lens epithelial cells and that this effect may be an important inducer in the pathological process of posterior capsule opacification (PCO). Human lens epithelial (HLE)‑B3 cells were exposed to an EF. Experiments were performed in the presence or absence of an anti‑integrin β1 blocking antibody or a small molecule inhibitor targeting focal adhesion kinase (FAK)...
July 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28764685/notch1-signaling-induces-epithelial-mesenchymal-transition-in-lens-epithelium-cells-during-hypoxia
#9
Lei Liu, Wei Xiao
BACKGROUND: Posterior Capsular Opacification (PCO) is one of the most common complications of cataract surgery which can result in severe visual damage. Epithelial-Mesenchymal Transition (EMT) of lens epithelium cells (LEC) is the pathological basis of PCO. Recent research showed that hypoxia acted as an inducer of EMT through a Notch1/Snail1/E-cadherin pathway. However, it remains unclear whether the Notch1/Snail1/E-cadherin pathway is involved in PCO under hypoxia. METHODS: The morphology of SRA01/04 cells treating with Cobalt Chloride (CoCl2) was observed and the markers of EMT and Notch1/Snail1/E-cadherin pathway were analyzed by Western blot and Immunocytochemistry assay...
August 1, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28732611/comparison-of-posterior-capsule-opacification-development-with-2%C3%A2-single-piece-intraocular-lens-types
#10
Christina Leydolt, Daniel Schartmüller, Luca Schwarzenbacher, Markus Schranz, Sabine Schriefl, Rupert Menapace
PURPOSE: To evaluate the differences in the incidence of posterior capsule opacification (PCO) and visual and optical performance between 2 hydrophobic acrylic single-piece sharp-edged intraocular lenses (IOLs) over 3 years. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. DESIGN: Prospective randomized case series. METHODS: Patients with bilateral cataract were prospectively randomized to receive an Eyecee One IOL (IOL A) or an Acrysof SN60WF IOL (IOL B) and were followed for 36 months...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28732603/pars-plana-posterior-capsulectomy-with-a-27-gauge-microincision-vitrectomy-system-for-dense-posterior-capsule-opacification
#11
Sathish Srinivasan, Zachariah Koshy
We describe a surgical technique of pars plana posterior capsulectomy using a transconjunctival sutureless 2-port 27-gauge microincision vitrectomy system to deal with dense posterior capsule opacification (PCO). The technique was used successfully in 5 eyes of 5 patients with dense PCO that had been unsuccessfully treated by neodymium:YAG laser photodisruption.
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28714205/photothermal-ring-integrated-intraocular-lens-for-high-efficient-eye-disease-treatment
#12
Yao-Xin Lin, Xue-Feng Hu, Yang Zhao, Yu-Juan Gao, Chao Yang, Sheng-Lin Qiao, Yi Wang, Pei-Pei Yang, Jiao Yan, Xin-Ce Sui, Zeng-Ying Qiao, Li-Li Li, Jiang-Bing Xie, Si-Quan Zhu, Xiao-Chun Wu, Yongsheng Li, Lei Wang, Hao Wang
Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, the only method for PCO treatment is the precisely focused laser surgery. However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (Nano-IOLs) is reported, in which the rim of commercially available IOLs (C-IOLs) is decorated with silica coated Au nanorods (Au@SiO2 ), for high-efficient prevention of PCO after cataract surgery...
July 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28704754/metabolomics-study-of-cadmium-induced-diabetic-nephropathy-and-protective-effect-of-caffeic-acid-phenethyl-ester-using-uplc-q-tof-ms-combined-with-pattern-recognition
#13
Pin Gong, Xiangna Chang, Xuefeng Chen, Xiaohuan Bai, He Wen, Sihui Pi, Wenjuan Yang, Lan Wang, Fuxin Chen
Diabetic nephropathy (DN) is the most severe complication of diabetes and multiple factors are involved in the pathogenesis of DN. Among them, cadmium (Cd) acts as a risk factor inducing the occurrence of DN. The present study focused on investigating the protective role of caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, against Cd-induced DN in mice based on ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS)and pattern recognition...
June 28, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28703800/killing-two-birds-with-one-stone-dual-blockade-of-integrin-and-fgf-signaling-through-targeting-syndecan-4-in-postoperative-capsular-opacification
#14
Yingyan Qin, Yi Zhu, Furong Luo, Chuan Chen, Xiaoyun Chen, Mingxing Wu
The most common complication after cataract surgery is postoperative capsular opacification, which includes anterior capsular opacification (ACO) and posterior capsular opacification (PCO). Increased adhesion of lens epithelial cells (LECs) to the intraocular lens material surface promotes ACO formation, whereas proliferation and migration of LECs to the posterior capsule lead to the development of PCO. Cell adhesion is mainly mediated by the binding of integrin to extracellular matrix proteins, while cell proliferation and migration are regulated by fibroblast growth factor (FGF)...
July 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28683652/effects-of-barium-graded-doses-on-redox-status-membrane-bound-atpases-and-histomorphological-aspect-of-the-liver-in-adult-rats
#15
Awatef Elwej, Mariem Chaabane, Imen Ghorbel, Sabrine Chelly, Tahia Boudawara, Najiba Zeghal
Nowadays, liver diseases constitute a major health problem in the world. The objective of the present study was to elucidate the hepatotoxicity induced by barium chloride (BaCl2) administered at graded doses in order to evaluate redox state and membrane-bound ATP-ases in the liver of adult rats. Our results showed, after 21 days of treatment with barium at doses 67,150 and 300 ppm, an increase in hepatic biomarkers such as AST, ALT and GGT activities and in bilirubin and albumin levels. A significant increase in MDA, LOOHs, H2O2, AOPP and PCO levels in liver of treated rats with graded doses of BaCl2 was also observed suggesting the implication of oxidative stress with a significant relation between dose and response...
July 6, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28643710/postoperative-posterior-capsular-striae-and-the-posterior-capsular-opacification-in-patients-implanted-with-two-types-of-intraocular-lens-material
#16
Rajesh Subhash Joshi
AIM: To evaluate the incidence of postoperative posterior capsular striae (PCS) and its influence on posterior capsular opacification (PCO) in patients implanted with two types of lens material. SETTING: Tertiary eye care center in central rural India. STUDY DESIGN: A prospective, observational, nonrandomized study. MATERIALS AND METHODS: The study included 1247 patients having age-related cataract scheduled for removal by phacoemulsification technique and implantation of hydrophilic or hydrophobic intraocular lens (IOL)...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28643028/polycystic-ovary-syndrome-adipose-tissue-and-metabolic-syndrome
#17
REVIEW
Alessandro P Delitala, Giampiero Capobianco, Giuseppe Delitala, Pier Luigi Cherchi, Salvatore Dessole
PURPOSE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age and is characterized by ovulatory dysfunction and/or androgen excess or polycystic ovaries. Women with PCOS present a number of systemic symptoms in addition to those related to the reproductive system. It has been associated with functional derangements in adipose tissue, metabolic syndrome, type 2 diabetes, and an increased risk of cardiovascular disease (CVD). METHODS: A detailed literature search on Pubmed was done for articles about PCOS, adipokines, insulin resistance, and metabolic syndrome...
June 22, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28640904/correlation-of-disease-severity-with-body-weight-and-high-fat-diet-in-the-fatzo-pco-mouse
#18
Brian A Droz, Bria L Sneed, Charles V Jackson, Karen M Zimmerman, M Dodson Michael, Paul J Emmerson, Tamer Coskun, Richard G Peterson
Obesity in many current pre-clinical animal models of obesity and diabetes is mediated by monogenic mutations; these are rarely associated with the development of human obesity. A new mouse model, the FATZO mouse, has been developed to provide polygenic obesity and a metabolic pattern of hyperglycemia and hyperinsulinemia, that support the presence of insulin resistance similar to metabolic disease in patients with insulin resistance/type 2 diabetes. The FATZO mouse resulted from a cross of C57BL/6J and AKR/J mice followed by selective inbreeding for obesity, increased insulin and hyperglycemia...
2017: PloS One
https://www.readbyqxmd.com/read/28640857/glucose-dysregulation-and-response-to-common-anti-diabetic-agents-in-the-fatzo-pco-mouse
#19
Richard G Peterson, Charles Van Jackson, Karen M Zimmerman, Jorge Alsina-Fernandez, M Dodson Michael, Paul J Emmerson, Tamer Coskun
The FATZO/Pco mouse is the result of a cross of the C57BL/6J and AKR/J strains. The crossing of these two strains and the selective inbreeding for obesity, insulin resistance and hyperglycemia has resulted in an inbred strain exhibiting obesity in the presumed presence of an intact leptin pathway. Routinely used rodent models for obesity and diabetes research have a monogenic defect in leptin signaling that initiates obesity. Given that obesity and its sequelae in humans are polygenic in nature and not associated with leptin signaling defects, the FATZO mouse may represent a more translatable rodent model for study of obesity and its associated metabolic disturbances...
2017: PloS One
https://www.readbyqxmd.com/read/28635410/pelvic-floor-dysfunction-and-polycystic-ovary-syndrome
#20
Seyed Abdolvahab Taghavi, Fatemeh Bazarganipour, Helen Allan, Zahra Khashavi, Nasrin Reisi, Nadiyeh Dosha, Fatemeh Aghili, Mohadeseh Keramati, Sedigheh Zahedi, Amireh Aji-Ramkani
The purpose of this study was to compare the prevalence of pelvic floor dysfunction (PFD) symptoms in patients with and without polycystic ovary syndrome (PCOS) and among different PCOS phenotypes. This was a case-control study. All participants were assessed using ultrasonography to determine the presence or absence of polycystic ovaries (PCO) and allocated to the case or control group (having healthy females whose husbands were diagnosed with male infertility). The case group was then further subdivided into the three phenotypes according to the presence or absence of menstrual dysfunction (M), hyperandrogenism (HA) and PCO on ultrasonography...
February 21, 2017: Human Fertility: Journal of the British Fertility Society
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