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https://www.readbyqxmd.com/read/29456813/evaluation-of-tnf-%C3%AE-and-il-6-mrnas-expressions-in-visceral-and-subcutaneous-adipose-tissues-of-polycystic-ovarian-rats-and-effects-of-resveratrol
#1
Mahnaz Ghowsi, Homayoun Khazali, Sajjad Sisakhtnezhad
Objectives: Some studies suggest that chronic low-grade inflammation is involved in insulin resistance in polycystic ovary syndrome (PCOS). This study assessed possible involvement of alteration in expression of two pro-inflammatory factors, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in adipose tissues of PCOS rats in the impairment of insulin actions. Also, effects of resveratrol as an anti-inflammatory agent were investigated. Materials and Methods: Fifteen female Wistar rats (21 days old) were divided into three groups (n=5): I) Control, II) PCO-model-saline: served as PCOS rats and to induce PCOS, received subcutaneously testosterone enanthate 1 mg/100 g body weight subcutaneously for 35 days, III) PCO-model-resveratrol, after receiving testosterone, received resveratrol 10 mg/kg intraperitoneally for 28 days...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29454185/preterm-infants-undergoing-laparotomy-for-necrotizing-enterocolitis-or-spontaneous-intestinal-perforation-display-evidence-of-impaired-cerebrovascular-autoregulation
#2
Sara J Kuik, Michelle E van der Laan, Margot T Brouwer-Bergsma, Jan B F Hulscher, Anthony R Absalom, Arend F Bos, Elisabeth M W Kooi
BACKGROUND: Preterm infants requiring surgery are at risk of impaired neurocognitive development caused, possibly, by cerebral ischemia associated with impaired cerebrovascular autoregulation (CAR). We evaluated CAR before, during, and after laparotomy. STUDY DESIGN: This was a hypothesis generating prospective observational cohort study. SUBJECTS: We included preterm infants requiring surgery for necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP)...
February 14, 2018: Early Human Development
https://www.readbyqxmd.com/read/29451997/poly-lactic-co-glycolic-acid-as-a-slow-release-drug-carrying-matrix-for-methotrexate-coated-onto-intraocular-lenses-to-conquer-posterior-capsule-opacification
#3
Stefan A Kassumeh, Christian M Wertheimer, Annabel von Studnitz, Anna Hillenmayer, Claudia Priglinger, Armin Wolf, Wolfgang J Mayer, Daniel Teupser, Lesca M Holdt, Siegfried G Priglinger, Kirsten H Eibl-Lindner
PURPOSE: Posterior capsule opacification (PCO) still represents the main long-term complication of cataract surgery. Research into pharmacologic PCO prophylaxis is extensive. One promising candidate drug is methotrexate (MTX). Our aim is to determine the in vitro feasibility of MTX-loaded poly(lactic-co-glycolic) (PLGA) biomatrices sprayed on intraocular lenses (IOLs) as a drug-delivery implant. METHODS: Hydrophilic and hydrophobic acrylic IOLs were spray-coated with MTX-loaded PLGA...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29448022/photosynthesis-and-mineralogy-of-jania-rubens-at-low-ph-high-pco-2-a-future-perspective
#4
Lucia Porzio, Maria Cristina Buia, Viviana Ferretti, Maurizio Lorenti, Manuela Rossi, Marco Trifuoggi, Alessandro Vergara, Carmen Arena
Corallinales (Rhodophyta) are high Mg-calcite macroalgae and are considered among the most vulnerable organisms to ocean acidification (OA). These sensitive species play fundamental roles in coastal systems as food source and settlement promoters as well as being involved in reef stabilization, and water carbonate balance. At present only a few studies are focused on erect calcifying macroalgae under low pH/high pCO 2 and the contrasting results make difficult to predict the ecological consequences of the OA on the coralline algae...
February 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29445537/neural-respiratory-drive-and-cardiac-function-in-patients-with-obesity-hypoventilation-syndrome-following-initiation-of-non-invasive-ventilation
#5
Angelo Onofri, Maxime Patout, Georgios Kaltsakas, Elodie Lhuillier, Sitali Mushemi-Blake, Gill Arbane, Martino F Pengo, Philip Marino, Joerg Steier
Background: Chronic hypercapnic respiratory failure (HRF) in obesity hypoventilation syndrome (OHS) is commonly treated using non-invasive ventilation (NIV). We hypothesised that treatment of OHS would improve neural respiratory drive index (NRDI) and cardiac function. Methods: Fourteen patients (8 females) with OHS, who were admitted for initiation of domiciliary NIV, were prospectively studied. Patients had (mean ± SD): age (53±10 years), body mass index (BMI) (50...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29433248/a-preliminary-exploration-of-the-potential-of-eugenia-uvalha-cambess-juice-intake-to-counter-oxidative-stress
#6
J M M Lopes, N N Lage, J F C Guerra, M Silva, L F Bonomo, A H S Paulino, A L R S Regis, M L Pedrosa, M E Silva
PURPOSE: The ability of foods to aid in the prevention of chronic metabolic diseases, has recently become an area of increased interest. In addition, there is growing interest in exploring the benefits of consuming underutilized fruits as alternatives to commercially available fruits. Eugenia uvalha Cambess (uvaia) is a native fruit of Brazil with great market and phytotherapy potential. The present study was conducted to investigate the effects of uvaia juice (UJ) on the levels of protein carbonyls (PCO) and antioxidant enzymes in the livers of rats fed a high-fat diet...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29428584/the-preliminary-association-study-of-adipoq-rbp4-and-bcmo1-variants-with-polycystic-ovary-syndrome-and-with-biochemical-characteristics-in-a-cohort-of-polish-women
#7
Ewa Czeczuga-Semeniuk, Marzenna Galar, Katarzyna Jarząbek, Piotr Kozłowski, Nela A Sarosiek, Sławomir Wołczyński
PURPOSE: We aimed to elucidate the frequency of the SNPs in the ADIPOQ, RBP4 and BCMO1genes in a population of Caucasian Polish women with polycystic ovary syndrome (PCOS), and to evaluate the possible associations between these variants and the susceptibility to PCOS. Additionally, the relationship of these polymorphisms to a clinical phenotype of this syndrome, and the concentrations of adipokines, were determined. MATERIALS/METHODS: Clinical and biochemical profiles, DNA isolation and genotyping, and adipokine assays were performed in 294 PCOS women and 78 controls...
February 7, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29416961/german-claims-data-analysis-to-assess-impact-of-different-intraocular-lenses-on-posterior-capsule-opacification-and-related-healthcare-costs
#8
Nils Kossack, Christian Schindler, Ines Weinhold, Lennart Hickstein, Moritz Lehne, Jochen Walker, Aljoscha S Neubauer, Dennis Häckl
Aim: Cataract extraction is one of the most frequent surgeries in Germany. In most cases, the clouded natural lens is replaced by a hydrophobic or hydrophilic acrylic intraocular lens (IOL) implant. The most common long-term complication after cataract surgery is the development of a posterior capsule opacification (PCO). Although no precise real world data are available, published evidence suggests a lower risk for PCO development for hydrophobic acrylic IOLs compared to hydrophilic acrylic IOLs...
2018: Journal of Public Health
https://www.readbyqxmd.com/read/29414756/synergistically-catalytic-oxidation-of-toluene-over-mn-modified-g-c3n4-zsm-4-under-vacuum-uv-irradiation
#9
Dehua Xia, Wenjun Xu, Lingling Hu, Chun He, Dennis Y C Leung, Wanjun Wang, Po Keung Wong
The process of vacuum ultraviolet (VUV)-assisted photocatalytic oxidation (PCO) has attracted great interest for volatile organic compounds (VOCs) degradation owing to its strong oxidation capability. However, the O3 by-product from VUV irradiation causes secondary pollution and needs to be overcome. In this study, a multi-functional photocatalyst of Mn/g-C3N4/ZSM-4 was thus developed by a one-pot hydrothermal method, and then combined with VUV irradiation to eliminate O3 byproduct as well as enhance toluene degradation via ozone-assisted catalytic oxidation (OZCO)...
February 1, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29403603/the-effect-of-consumption-of-garlic-tablet-on-proteins-oxidation-biomarkers-in-postmenopausal-osteoporotic-women-a-randomized-clinical-trial
#10
Fereshte Ahmadian, Hassan Mozaffari-Khosravi, Mohammad Hossein Azaraein, Reza Faraji, Javad Zavar-Reza
Background: Osteoporosis (OP) is one of the most prevalent metabolic bone diseases at higher ages, especially in postmenopausal women. Objective: To determine the effect of consumption of garlic tablet on proteins oxidation biomarkers in postmenopausal osteoporotic women. Methods: The present study was a double-blind randomized controlled clinical trial that included 42 postmenopausal women in Yazd during 2014-2015. Osteoporotic women were randomly assigned into two groups: the garlic group (GG) and the placebo group (PG)...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29369535/long-term-uveal-and-capsular-biocompatibility-of-a-novel-modular-intraocular-lens-system
#11
Jason Ludlow, Jason Nguyen, Joah Aliancy, Bryan Masino, Larry Ha, Liliana Werner, Nick Mamalis
BACKGROUND: We evaluated the long-term biocompatibility and safety of a new modular posterior chamber intraocular lens (IOL) system in rabbit eyes. METHODS: Seven New Zealand rabbits underwent bilateral phacoemulsification with placement of the modular IOL in OD and a control IOL (SA60AT) in OS. Slit-lamp examinations were performed at postoperative weeks 1, 2, 3, 4, 6 and 8 and months 3 and 6. All rabbits were then sacrificed and eyes enucleated. The eyes were examined grossly from the Miyake-Apple view...
January 25, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29357489/the-partial-pressure-of-carbon-monoxide-in-human-tissues-calculated-using-a-parallel-capillary-tissue-cylinder-model
#12
Ronald F Coburn
Tissue PCO values have not been previously estimated under conditions where the blood carboxyhemoglobin % saturation ([COHb]) is at a normal level or increased. Tissue PCO are not known for conditions when [COHb] is increased during CO therapy or during CO poisoning. Using a modified Krogh parallel capillary-tissue model, mean tissue PCO were calculated for when [COHb] were 1, 5, 10, 15% saturation, relevant to CO therapy, and 20, 30, and 40% saturation, relevant to CO poisoning. Calculations were made for the time during which CO was being inhaled, after cessation of CO uptake, and for different O2 extractions from blood flowing in the model capillary...
January 4, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29344639/therapeutic-potential-of-a-dual-mtorc1-2-inhibitor-for-the-prevention-of-posterior-capsule-opacification-an-in-vitro-study
#13
Hao Feng, Zhibo Yang, Xue Bai, Meirong Yang, Yuan Fang, Xiaonan Zhang, Qiqiang Guo, Hong Ning
Mammalian target of rapamycin (mTOR) serves a central role in regulating cell growth and survival, and has been demonstrated to be involved in the pathological progression of posterior capsule opacification (PCO). In the present study, the potency of PP242, a novel dual inhibitor of mTOR complex 1/2 (mTORC1/2), in the suppression of the growth of human lens epithelial cells (HLECs) was investigated. Using a Cell Counting Kit‑8 and a wound healing assay, it was demonstrated that PP242 inhibited the proliferation and migration of HLECs...
January 18, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29343034/-a-study-on-the-effects-and-safety-of-sequential-humidified-high-flow-nasal-cannula-oxygenation-therapy-on-the-copd-patients-after-extubation
#14
J C Zhang, F X Wu, L L Meng, C Y Zeng, Y Q Lu
Objective: To investigate and compare the effect and safety of nasal high-flow oxygen therapy (HFNCO) and noninvasive ventilation (NIV) therapy after extubation in patients with chronic obstructive pulmonary disease (COPD). Methods: All COPD patients subjected to mechanical ventilation in the Emergency Intensive Unit of the First Affiliated Hospital of Zhejiang University during January 2015 to June 2016 were included in the study. The patients were divided into two groups after extubation and HFNCO and NIV were adopted on each group respectively...
January 9, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29338198/atomic-resolution-imaging-of-nanoscale-chemical-expansion-in-prxce1-xo2-%C3%AE-during-in-situ-heating
#15
Jessica G Swallow, Ja Kyung Lee, Thomas Defferriere, Gareth Martin Hughes, Shilpa N Raja, Harry L Tuller, Jamie H Warner, Krystyn J Van Vliet
Thin film non-stoichiometric oxides enable many high temperature applications including solid oxide fuel cells, actuators, and catalysis. Large concentrations of point defects (particularly, oxygen vacancies) enable fast ionic conductivity or gas exchange kinetics in these materials, but also manifest as coupling between lattice volume and chemical composition. This chemical expansion may be either detrimental or useful, especially in thin film devices that may exhibit enhanced performance through strain engineering or decreased operating temperatures...
January 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29330345/a-computational-simulation-study-to-determine-the-biomechanical-influence-of-posterior-condylar-offset-and-tibial-slope-in-cruciate-retaining-total-knee-arthroplasty
#16
K-T Kang, Y-G Koh, J Son, O-R Kwon, J-S Lee, S K Kwon
OBJECTIVES: Posterior condylar offset (PCO) and posterior tibial slope (PTS) are critical factors in total knee arthroplasty (TKA). A computational simulation was performed to evaluate the biomechanical effect of PCO and PTS on cruciate retaining TKA. METHODS: We generated a subject-specific computational model followed by the development of ± 1 mm, ± 2 mm and ± 3 mm PCO models in the posterior direction, and -3°, 0°, 3° and 6° PTS models with each of the PCO models...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29316112/an-isolable-phosphaethynolato-borane-and-its-reactivity
#17
Daniel Wilson, Alexander Hinz, Jose Manuel Goicoechea
The synthesis and characterization of a stable phosphaethynolato-borane, [B]OCP (1, [B] = N,N'-bis(2,6-diisopropylphenyl)-2,3-dihydro-1H-1,3,2-diazaboryl), is described. The increased triple bond character of the P-C bond in 1 relative to the free ion (PCO-) is probed in a series of reactivity studies. Compound 1 readily dimerises in donor solvents to afford a cyclic five-membered 6π-aromatic compound, cyclo-P2{C[B]}O{CO[B]} (2), which decarbonylates on UV irradiation. By contrast the nickel-mediated dimerisation of 1 affords the isomeric diphosphacyclobutene [P(CO[B])]2...
January 8, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29307742/is-double-metatarsal-osteotomy-superior-to-proximal-chevron-osteotomy-in-treatment-of-hallux-valgus-with-increased-distal-metatarsal-articular-angle
#18
Chul Hyun Park, Woo-Chun Lee
We compared the results of proximal chevron osteotomy and double metatarsal osteotomy for hallux valgus with an increased distal metatarsal articular angle (DMAA). From October 2008 to December 2012, first metatarsal osteotomies were performed in 64 patients (69 feet) with symptomatic hallux valgus associated with an increased DMAA. Proximal chevron with Akin osteotomy and lateral soft tissue release was performed in 46 feet (PCO group); double metatarsal osteotomy and Akin osteotomy without lateral soft tissue release was performed in 23 feet (DMO group)...
January 5, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29275919/melatonin-administration-lowers-biomarkers-of-oxidative-stress-and-cardio-metabolic-risk-in-type-2-diabetic-patients-with-coronary-heart-disease-a-randomized-double-blind-placebo-controlled-trial
#19
Fariba Raygan, Vahidreza Ostadmohammadi, Fereshteh Bahmani, Russel J Reiter, Zatollah Asemi
BACKGROUND & AIMS: Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk. This investigation evaluated the effects of melatonin administration on metabolic status in diabetic patients with CHD. METHODS: This randomized, double-blind, placebo-controlled trial was conducted and involved 60 diabetic patients with CHD. Subjects were randomly allocated into two groups to receive either 10 mg melatonin (2 melatonin capsules, 5 mg each) (n = 30) or placebo (n = 30) once a day for 12 weeks...
December 12, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29273352/evaluation-of-different-ranges-of-lh-fsh-ratios-in-polycystic-ovarian-syndrome-pcos-clinical-based-case-control-study
#20
N A Malini, K Roy George
BACKGROUND: Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine and metabolic disorder among reproductive aged women, leading to infertility. One of the common clinical manifestations in PCOS is that there is a difference in the range of LH production in different case of PCOS and accordingly variability in LH:FSH ratio was observed. OBJECTIVE: The aim of the present study was to evaluate different ranges of LH:FSH ratios in PCOS. EXPERIMENTAL DESIGN: In this cross sectional study, a consecutive series of 745 women (aged 28...
December 19, 2017: General and Comparative Endocrinology
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