keyword
https://read.qxmd.com/read/38519794/perinatal-compromise-affects-development-form-and-function-of-the-hippocampus-part-one-clinical-studies
#21
REVIEW
Tegan A White, Suzanne L Miller, Amy E Sutherland, Beth J Allison, Emily J Camm
The hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. In human fetal development, hippocampal neurogenesis is principally complete by mid-gestation, with subsequent maturation comprising dendritogenesis and synaptogenesis in the third trimester of pregnancy and infancy. Dendritogenesis and synaptogenesis underpin connectivity. Hippocampal development is exquisitely sensitive to perturbations during pregnancy and at birth...
March 22, 2024: Pediatric Research
https://read.qxmd.com/read/38519607/perinatal-and-neonatal-factors-and-mental-disorders-in-children-and-adolescents-looking-for-the-contributions-of-the-early-environment-to-common-and-dissociable-aspects-of-psychopathology
#22
JOURNAL ARTICLE
Fabiane Leusin, Rodolfo Furlan Damiano, Lorenna Sena Teixeira Mendes, Maurício Scopel Hoffmann, Arthur Gus Manfro, Pedro Mario Pan, Ary Gadelha, Jair de Jesus Mari, Gisele Gus Manfro, Eurípedes Constantino Miguel, Luis Augusto Rohde, Rodrigo Affonseca Bressan, Giovanni Abrahão Salum
High rates of co-occurrence of mental disorders have been hypothesized to represent a result of common susceptibility to overall psychopathology. The purpose of this study is to test the hypothesis that commonalities among psychiatric disorders might be partially driven by sharable perinatal and neonatal environmental factors for mental disorders. Participants were 6-14 years of age children and their parents. Primary caregivers provided data on perinatal and neonatal information assessed retrospectively (n = 2231)...
March 22, 2024: European Child & Adolescent Psychiatry
https://read.qxmd.com/read/38519441/management-and-outcomes-of-women-with-low-fibrinogen-concentration-during-pregnancy-or-immediately-postpartum-a-uk-national-population-based-cohort-study
#23
JOURNAL ARTICLE
Caroline Diguisto, Elfreda Baker, Simon Stanworth, Peter W Collins, Rachel E Collis, Marian Knight
INTRODUCTION: Pregnant women with a fibrinogen level <2 g/L represent a high-risk group that is associated with severe postpartum hemorrhage and other complications. Women who would qualify for fibrinogen therapy are not yet identified. MATERIAL AND METHODS: A population-based cross-sectional study was conducted using the UK Obstetric Surveillance System between November 2017 and October 2018 in any UK hospital with a consultant-led maternity unit. Any woman pregnant or immediately postpartum with a fibrinogen <2 g/L was included...
March 22, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38519042/evaluation-of-fetal-breathing-related-nasal-fluid-flow-doppler-in-the-third-trimester-in-pregnant-women-with-fetal-growth-restriction-preliminary-observations
#24
JOURNAL ARTICLE
Gunay Rzayeva, İbrahim Kale, Resul Arısoy, Murat Muhcu
OBJECTIVE: To investigate the fetal breathing-related nasal fluid flow Doppler waveforms as an indicator of fetal respiratory function in fetuses diagnosed with fetal growth restriction (FGR) in the third trimester. MATERIALS AND METHODS: This prospective, non-interventional case-control study was conducted on 96 pregnant women, including 23 pregnant women diagnosed with FGR in the third trimester as the FGR group and 73 healthy pregnant women with fetuses appropriate for gestational age (AGA) as the control group...
March 22, 2024: Zeitschrift Für Geburtshilfe und Neonatologie
https://read.qxmd.com/read/38515427/trajectories-tracking-of-maternal-and-neonatal-health-in-eastern-china-from-2010-to-2021-a-multicentre-cross-sectional-study
#25
JOURNAL ARTICLE
Hui Zhu, Jie Cai, Hongyi Liu, Zhijia Zhao, Yanming Chen, Penghao Wang, Tao Chen, Da He, Xiang Chen, Jin Xu, Lindan Ji
BACKGROUND: China's fertility policy has dramatically changed in the past decade with the successive promulgation of the partial two-child policy, universal two-child policy and three-child policy. The trajectories of maternal and neonatal health accompanied the changes in fertility policy are unknown. METHODS: We obtained data of 280 203 deliveries with six common pregnancy complications and thirteen perinatal outcomes between 2010 and 2021 in eastern China...
March 22, 2024: Journal of Global Health
https://read.qxmd.com/read/38515238/idiopathic-intracranial-hypertension-and-obstetric-and-neonatal-outcomes-a-1-20-matched-study-from-a-population-database
#26
JOURNAL ARTICLE
Uri Amikam, Haitham Baghlaf, Ahmad Badeghiesh, Richard Brown, Michael H Dahan
OBJECTIVE: Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a common pathology in reproductive-aged women, although data regarding pregnancy outcomes are scarce. In the present study, we aimed to compare pregnancy and perinatal outcomes between women who suffered from IIH to those who did not. METHODS: A retrospective cohort study using the Healthcare Cost and Utilization Project, Nationwide Inpatient Sample. All pregnant women who delivered or had a maternal death in the US (2004-2014) were included...
March 21, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38515025/sex-and-fetal-genome-influence-gene-expression-in-pig-endometrium-at-the-end-of-gestation
#27
JOURNAL ARTICLE
Agnes Bonnet, Lisa Bluy, Laure Gress, Laurianne Canario, Laure Ravon, Aurelie Sécula, Yvon Billon, Laurence Liaubet
BACKGROUND: A fine balance of feto-maternal resource allocation is required to support pregnancy, which depends on interactions between maternal and fetal genetic potential, maternal nutrition and environment, endometrial and placental functions. In particular, some imprinted genes have a role in regulating maternal-fetal nutrient exchange, but few have been documented in the endometrium. The aim of this study is to describe the expression of 42 genes, with parental expression, in the endometrium comparing two extreme breeds: Large White (LW); Meishan (MS) with contrasting neonatal mortality and maturity at two days of gestation (D90-D110)...
March 21, 2024: BMC Genomics
https://read.qxmd.com/read/38514743/erythropoietin-and-retinopathy-of-prematurity-a-retrospective-cohort-study-in-japan-2008-2018
#28
JOURNAL ARTICLE
Kana Fukui, Yushi Ito, Masayo Kokubo, Hidehiko Nakanishi, Shinya Hirano, Satoshi Kusuda, Shuichi Ito, Tetsuya Isayama
BACKGROUND: Erythropoietin has an angiogenic effect on the retina and might increase the risk of retinopathy of prematurity (ROP). METHODS: This retrospective cohort study included infants born at 22 to 27 weeks' gestation between 2008 and 2018 who were admitted to neonatal intensive care units (NICUs). We compared mortality and morbidities between infants who received erythropoietin and those who did not. RESULTS: Among 18,955 livebirth infants, this study included 16,031 infants, among which 14,373 infants received erythropoietin...
March 21, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/38514742/use-of-urine-neutrophil-gelatinase-associated-lipocalin-for-nephrotoxic-medication-acute-kidney-injury-screening-in-neonates
#29
JOURNAL ARTICLE
Cara L Slagle, Trina Hemmelgarn, Hailey W Gavigan, Kelli A Krallman, Stuart L Goldstein
BACKGROUND: Daily serum creatinine monitoring protocols for acute kidney injury (AKI) are invasive and may lead to surveillance resistance. We aimed to understand if use of urine neutrophil gelatinase-associated lipocalin (uNGAL) could increase high-risk nephrotoxic medication (NTMx) associated AKI screening adherence in neonates. METHODS: Statistical process control methods prior to and post implementation were trended. The primary outcome, screening adherence, was defined as either daily serum creatinine or uNGAL assessment through 2 days post high-risk NTMx exposure...
March 21, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/38514741/is-it-time-for-a-precision-health-approach-to-the-management-of-newborn-hyperbilirubinemia
#30
REVIEW
David K Stevenson, Grant S Wells, Ronald J Wong
Newborn hyperbilirubinemia during the first two weeks of life is one of most common problems requiring management decisions by a pediatrician. However, high bilirubin levels in the circulation have been associated with neurologic injury under a variety of conditions encountered in the newborn infant, such as hemolysis. The risk for developing dangerous hyperbilirubinemia is multifactorial and is determined by a complex set of factors related to a newborn infant's genetic capacities as well as intra- and extrauterine exposures...
March 21, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/38513806/concurrent-progestogen-and-cerclage-to-reduce-preterm-birth-a-multicenter-international-retrospective-cohort
#31
JOURNAL ARTICLE
Jorge E Tolosa, Rupsa C Boelig, Joseph Bell, María Martínez-Baladejo, Jill Stoltzfus, Julio Mateus, Joanne N Quiñones, Santiago Galeano-Herrera, Leonardo Pereira, Richard Burwick, Luisa López-Torres, Catalina Valencia, Vincenzo Berghella
OBJECTIVE: We aimed to evaluate whether cerclage with progestogen therapy was superior to cerclage alone in the prevention of spontaneous preterm birth (sPTB) in singleton pregnancies METHODS: : This is an international retrospective cohort study of singleton pregnancies, without major anomaly or aneuploidy, and with cerclage placed at 10 different institutions in the United States and Colombia from June 2016-June 2020. Exclusion criteria were: lack of documentation regarding whether progestogen was or was not prescribed, delivery outcome unavailable, and pregnancy termination (spontaneous or induced) prior to 16 weeks' gestation...
March 19, 2024: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/38513533/associations-of-maternal-sleep-trajectories-during-pregnancy-and-adverse-perinatal-outcomes-a-prospective-cohort-study
#32
JOURNAL ARTICLE
Zhi Li, Shanshan Cui, Hui Wang, Wenjuan Xiong, Yu Han, Wei Dai, Wei Xi, Tingkai Cui, Xin Zhang
OBJECTIVE: Sleep problems are common in pregnant women and sleep is altered during pregnancy. However, the associations between sleep trajectory patterns and adverse maternal and neonatal outcomes are unclear. The current study aims to identify sleep trajectory patterns and explore their associations with adverse perinatal outcomes in a prospective cohort study. METHODS: Pregnant women (N = 232) completed the Pittsburgh Sleep Quality Index each trimester during pregnancy in Tianjin, China...
March 16, 2024: Sleep Medicine
https://read.qxmd.com/read/38511669/second-twin-outcome-at-birth-retrospective-analysis-in-a-single-tertiary-centre-in-malaysia
#33
JOURNAL ARTICLE
Rahana Abd Rahman, Azmawati Mohammed Nawi, Shareena Ishak, Kartik Balaraman, Mohamad Azrai Abu, Siti Hajar Abd Azman, Aida Hani Kalok, Nor Azlin Mohamed Ismail, Zaleha Abdullah Mahdy, Shuhaila Ahmad
OBJECTIVES: To investigate factors associated with outcome of second twin during labour. METHODS: The study was a retrospective cohort study in a single tertiary centre in Malaysia from 2014 until 2018 involving all twin pregnancies delivered at or more than 24 weeks of gestation. RESULTS: Total of 409 twin pregnancies were included. Dichorionic twin comprises of 54.5 % (n=223) and 45.5 % (n=186) are monochorionic. Women with dichorionic pregnancies are significantly older (p<0...
March 22, 2024: Journal of Perinatal Medicine
https://read.qxmd.com/read/38511150/preterm-birth-a-neuroinflammatory-origin-for-metabolic-diseases
#34
REVIEW
Sihao Diao, Chao Chen, Alexandre Benani, Christophe Magnan, Juliette Van Steenwinckel, Pierre Gressens, Céline Cruciani-Guglielmacci, Alice Jacquens, Cindy Bokobza
Preterm birth and its related complications have become more and more common as neonatal medicine advances. The concept of "developmental origins of health and disease" has raised awareness of adverse perinatal events in the development of diseases later in life. To explore this concept, we propose that encephalopathy of prematurity (EoP) as a potential pro-inflammatory early life event becomes a novel risk factor for metabolic diseases in children/adolescents and adulthood. Here, we review epidemiological evidence that links preterm birth to metabolic diseases and discuss possible synergic roles of preterm birth and neuroinflammation from EoP in the development of metabolic diseases...
May 2024: Brain, behavior, & immunity health
https://read.qxmd.com/read/38510919/perceptions-of-health-care-workers-on-maternal-and-child-health-services-in-pakistan-during-covid-19-a-cross-sectional-study
#35
JOURNAL ARTICLE
Jamil Ahmed, Ramesh Kumar, Vikram Mehraj, Amer Almarabheh, Sadiq Ali Khowaja, Shahzad Ali Khan, Nawal Naeem, Sathirakorn Pongpanich
BACKGROUND: Maternal and child healthcare service delivery in vulnerable and fragile health systems has suffered a tremendous impact owing to the shift in focus to curtail the COVID-19 pandemic. We aimed to evaluate the impact of the COVID-19 pandemic on maternal and child healthcare services to inform policy advice for a more resilient maternal and child healthcare service delivery in Pakistan. METHODS: A descriptive cross-sectional study was conducted. A structured and validated questionnaire was transformed into an online version and a link was first sent to about 300 healthcare professionals to achieve a sample size of 203, including medical doctors, nurses, and other paramedical staff working in public sector health facilities of the four provinces of Pakistan...
December 2023: Dialogues Health
https://read.qxmd.com/read/38510456/risk-of-adverse-perinatal-outcomes-among-women-with-clinical-and-subclinical-histopathological-chorioamnionitis
#36
JOURNAL ARTICLE
Andrea Olguín-Ortega, Ricardo Figueroa-Damian, Martha Leticia Palafox-Vargas, Enrique Reyes-Muñoz
INTRODUCTION: Histologic chorioamnionitis (HCA) is a placental inflammatory condition associated with adverse perinatal outcomes (APOs). This historical cohort study explores the risk of APOs in pregnant women with HCA and compares the impact of clinical chorioamnionitis (CCA) with subclinical chorioamnionitis (SCCA). METHODOLOGY: Placentas were evaluated by a perinatal pathologist tand all women with HCA were included. Two groups were integrated: (1) women with clinical chorioamnionitis (CCA) and (2) women with subclinical chorioamnionitis (SCCA)...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38509202/urine-biomarkers-of-acute-kidney-injury-and-association-with-brain-mri-abnormalities-in-neonatal-hypoxic-ischemic-encephalopathy
#37
JOURNAL ARTICLE
Megan J Turner, Jennifer A Rumpel, Beverly J Spray, Nicholas Stence, Ilana Neuberger, Adam Frymoyer, Valerie Y Chock, Sherry Courtney, Katja Gist
OBJECTIVE: Determine whether urine biomarkers NGAL (neutrophil gelatinase-associated lipocalin), KIM-1 (kidney injury molecule 1) and IL-18 (interleukin-18) are associated with abnormal MRI findings in neonates with hypoxic-ischemic encephalopathy (HIE) who underwent therapeutic hypothermia (TH). STUDY DESIGN: Secondary analysis of a multicenter, prospective study of neonates with HIE requiring TH. Urine biomarkers were obtained at 12 and 24 h of life (HOL)...
March 20, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/38504758/contributory-factors-to-early-neonatal-deaths-in-the-upper-east-regional-hospital-in-ghana
#38
JOURNAL ARTICLE
Francis K Wuni, Margaret W Kukeba, Yakubu Zakariah, Emmanuella A Nyaabila, Aiden S Saanwie
OBJECTIVE: This study examined factors identified during early neonatal death audits contributing to preventable newborn deaths at the Upper East Regional Hospital. METHOD: Data for this study was collected retrospectively from perinatal death audit forms using three data collectors. Data collection lasted two weeks, from 18th June to 2nd July 2021. The data collectors submitted 113 filled hard copy data collection forms. This was then entered into a designed Excel sheet and exported to STATA software version 15...
June 2023: Ghana Medical Journal
https://read.qxmd.com/read/38504477/changes-in-attitudes-to-childbirth-in-modern-times-illustrated-over-three-generations-in-iraq
#39
JOURNAL ARTICLE
Fatima Junaid, Ailsa Bradbury, Taghreed Alhaidari, Ali Kubba
OBJECTIVE: To describe changes in attitudes and expectations of labor over the previous six decades, comparing the Iraqi generation who labored at home without medical assistance with their descendants. STUDY DESIGN: We used semi-structured telephone interviews with 22 women across three generations of one extended family living and giving birth in Iraq between the 1950s and the 2010s. Qualitative data were analyzed thematically using open, axial, and selective coding...
March 19, 2024: Birth
https://read.qxmd.com/read/38504476/cannabis-exposure-during-pregnancy-and-perinatal-outcomes-a-cohort-study
#40
JOURNAL ARTICLE
Maia Brik, Miguel Sandonis, Alina Hernández-Fleury, Judit Gil, Miriam Mota, Francisco José Barranco, Itziar Garcia, Nerea Maiz, Elena Carreras
INTRODUCTION: Cannabis potency and its use during pregnancy have increased in the last decade. The aim of this study was to investigate the impact of antenatal cannabis use on fetal growth, preterm birth and other perinatal outcomes. MATERIAL AND METHODS: A propensity score-matched analysis was performed in women with singleton pregnancies attending a tertiary care site in Barcelona. Women in the cannabis group were selected based on the results of a detection test...
March 19, 2024: Acta Obstetricia et Gynecologica Scandinavica
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