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https://www.readbyqxmd.com/read/28938661/efficacy-and-safety-of-accelerated-partial-breast-irradiation-a-meta-analysis-of-published-randomized-studies
#1
Gengchun Liu, Zhongyi Dong, Baqun Huang, Yuelong Liu, Yan Tang, Qing Li, Yihui Zhu
BACKGROUND AND PURPOSE: Accelerated partial breast irradiation (APBI) technology has theoretical advantages in comparison with traditional adjuvant radiation therapy (whole-breast irradiation; WBI) after breast-conserving surgery. However, published randomized controlled trials have shown inconsistent outcomes. Therefore, a comprehensive assessment of the effectiveness and safety of APBI technology is needed. RESULTS: A total of 7 studies of 7452 patients were included in this analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938618/beclin-1-and-lc3-as-predictive-biomarkers-for-metastatic-colorectal-carcinoma
#2
Hong Zhao, Maopeng Yang, Bin Zhao
Autophagy is a highly conserved self-destructive process that disassembles dysfunctional or unnecessary cellular components. It plays an important role in cancer metastasis, which is of particular interest considering metastatic disease is the major cause of colorectal carcinoma (CRC) related mortality. Here, we investigated the immunohistochemical expression of autophagy-related protein Beclin 1 and Microtubule-associated protein 1A/1B-light chain 3 (LC3) within surgical CRC specimens, first in a training cohort (205 patients), then in an inner validation cohort (160 patients) and an independent cohort (161 patients)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938540/microrna-128-3p-regulates-mitomycin-c-induced-dna-damage-response-in-lung-cancer-cells-through-repressing-sptan1
#3
Rui Zhang, Chang Liu, Yahan Niu, Ying Jing, Haiyang Zhang, Jin Wang, Jie Yang, Ke Zen, Junfeng Zhang, Chen-Yu Zhang, Donghai Li
The DNA damage response is critical for maintaining genome integrity and preventing damage to DNA due to endogenous and exogenous insults. Mitomycin C (MMC), a potent DNA cross-linker, is used as a chemotherapeutic agent because it causes DNA inter-strand cross-links (DNA ICLs) in cancer cells. While many microRNAs, which may serve as oncogenes or tumor suppressors, are grossly dysregulated in human cancers, little is known about their roles in MMC-treated lung cancer. Here, we report that miR-128-3p can attenuate repair of DNA ICLs by targeting SPTAN1 (αII Sp), resulting in cell cycle arrest and promoting chromosomal aberrations in lung cancer cells treated with MMC...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938445/mini-review-discovery-of-gnih-and-its-role-in-hypothyroidism-induced-delayed-puberty
#4
Kazuyoshi Tsutsui, You Lee Son, Mika Kiyohara, Ichiro Miyata
It is known that hypothyroidism delays puberty in mammals. Interaction between the hypothalamo-pituitary-thyroid (HPT) and hypothalamo-pituitary-gonadal (HPG) axes may be important processes in delayed puberty. Gonadotropin-inhibitory hormone (GnIH) is a newly discovered hypothalamic neuropeptide inhibiting gonadotropin synthesis and release in quail. It now apperas that GnIH is conserved across various mammals and primates including humans and inhibits reproduction. We have further demonstrated that GnIH is involved in pubertal delay induced by thyroid dysfunction in female mice...
September 18, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938124/the-kinetochore-receptor-for-the-cohesin-loading-complex
#5
Stephen M Hinshaw, Vasso Makrantoni, Stephen C Harrison, Adèle L Marston
The ring-shaped cohesin complex brings together distant DNA domains to maintain, express, and segregate the genome. Establishing specific chromosomal linkages depends on cohesin recruitment to defined loci. One such locus is the budding yeast centromere, which is a paradigm for targeted cohesin loading. The kinetochore, a multiprotein complex that connects centromeres to microtubules, drives the recruitment of high levels of cohesin to link sister chromatids together. We have exploited this system to determine the mechanism of specific cohesin recruitment...
September 21, 2017: Cell
https://www.readbyqxmd.com/read/28938122/genome-regulation-by-polycomb-and-trithorax-70-years-and-counting
#6
REVIEW
Bernd Schuettengruber, Henri-Marc Bourbon, Luciano Di Croce, Giacomo Cavalli
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states. Recently, they have been shown to globally control a plethora of cellular processes. This functional diversity is achieved by their ability to regulate chromatin at multiple levels, ranging from modifying local chromatin structure to orchestrating the three-dimensional organization of the genome...
September 21, 2017: Cell
https://www.readbyqxmd.com/read/28938017/a-highly-conserved-amino-acid-in-vp1-regulates-maturation-of-enterovirus-71
#7
Yong-Xin Zhang, Yu-Ming Huang, Quan-Jie Li, Xiao-Yu Li, Yong-Dong Zhou, Fei Guo, Jin-Ming Zhou, Shan Cen
Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease (HFMD) in children, causing severe clinical outcomes and even death. Here, we report an important role of the highly conserved alanine residue at position 107 in the capsid protein VP1 (VP1A107) in the efficient replication of EV71. Substitutional mutations of VP1A107 significantly diminish viral growth kinetics without significant effect on viral entry, expression of viral genes and viral production. The results of mechanistic studies reveal that VP1A107 regulates the efficient cleavage of the VP0 precursor during EV71 assembly, which is required, in the next round of infection, for the transformation of the mature virion (160S) into an intermediate or A-particle (135S), a key step of virus uncoating...
September 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28937898/selective-reduction-of-talon-cusps-a-case-series
#8
Rona Leith, Anne C O'Connell
Talon cusps associated with permanent incisors are a rare occurrence but can cause numerous complications. When treatment is indicated options include radical or selective reduction of the accessory cusp, but there is no standard protocol for management. STUDY DESIGN: Patients referred to the Dublin Dental University Hospital for treatment of talon cusps were identified, contacted and consent obtained. Clinical notes, photographs and radiographs were retrospectively reviewed. RESULTS: Eleven patients with 14 talon cusps were identified...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937885/vanishing-mandible-in-a-7-year-old-child-response-to-radiation-therapy
#9
Mounabati Mohapatra, Ashok Kumar Jena, Arun Kumar Dandapat, Sombir Singh
Massive osteolysis in a 7-year old child is a rare condition. The etiology of massive osteolysis is unknown and it results in the progressive destruction of bony structures. There is no standard therapy available in the literature. Conservative treatment is often used for its management. Radiotherapy is considered as an accepted form of treatment with greater chance of success when it is used in the early course of disease. There are few case reports in the literature in which radiotherapy has been used for the treatment...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937658/extracellular-vesicle-associated-rna-as-a-carrier-of-epigenetic-information
#10
REVIEW
Carlo Maria Di Liegro, Gabriella Schiera, Italia Di Liegro
Post-transcriptional regulation of messenger RNA (mRNA) metabolism and subcellular localization is of the utmost importance both during development and in cell differentiation. Besides carrying genetic information, mRNAs contain cis-acting signals (zip codes), usually present in their 5'- and 3'-untranslated regions (UTRs). By binding to these signals, trans-acting factors, such as RNA-binding proteins (RBPs), and/or non-coding RNAs (ncRNAs), control mRNA localization, translation and stability. RBPs can also form complexes with non-coding RNAs of different sizes...
September 22, 2017: Genes
https://www.readbyqxmd.com/read/28937654/genome-wide-analysis-of-cca1-like-proteins-in-soybean-and-functional-characterization-of-gmmyb138a
#11
Shaomin Bian, Donghao Jin, Ruihua Li, Xin Xie, Guoli Gao, Weikang Sun, Yuejia Li, Lulu Zhai, Xuyan Li
Plant CIRCADIAN CLOCK ASSOCIATED1 (CCA1)-like proteins are a class of single-repeat MYELOBLASTOSIS ONCOGENE (MYB) transcription factors generally featured by a highly conserved motif SHAQK(Y/F)F, which play important roles in multiple biological processes. Soybean is an important grain legume for seed protein and edible vegetable oil. However, essential understandings regarding CCA1-like proteins are very limited in soybean. In this study, 54 CCA1-like proteins were identified by data mining of soybean genome...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28937614/a-novel-vav3-homolog-identified-in-lamprey-lampetra-japonica-with-roles-in-lipopolysaccharide-mediated-immune-response
#12
Yanqi Shen, Yishan Zhang, Yinglun Han, Peng Su, Meng Gou, Yue Pang, Qingwei Li, Xin Liu
Vav guanine nucleotide exchange factor 3 (Vav3), a Rho family GTPase, regulates multiple cell signaling pathways including those of T- and B-cell receptors in vertebrates through mediating the activities of the Rho family members. Whether the lamprey possesses Vav3 homolog and what role it plays in immune response remain unknown. Gene cloning, recombinant expression, antibody production and expression pattern analyses were performed to characterize the lamprey Vav3 in the current study. The lamprey Vav3 is closer to jawed vertebrates' Vav3 molecules (about 53% identities in general) than to Vav2 molecules of jawless and jawed vertebrates (about 51% identities in general) in sequence similarity...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28937468/psychogenic-low-back-pain-and-hysterical-paralysis-in-adolescence
#13
Tsukasa Kanchiku, Hidenori Suzuki, Yasuaki Imajo, Yuichiro Yoshida, Norihiro Nishida, Toshihiko Taguchi
STUDY DESIGN: A retrospective review. OBJECTIVE: The purpose of this study was to investigate the clinical outcomes in adolescents diagnosed with psychogenic low-back pain and hysterical paralysis and to evaluate the efficacy of differential diagnosis methods. SUMMARY OF BACKGROUND DATA: The incidence of low-back pain in adolescence is similar to that in adults, but the causes of low-back pain are difficult to determine in most cases. For these patients, a definitive diagnosis of psychogenic low-back pain and hysterical paralysis as well as adequate treatment are clinically important to avoid unnecessary surgical treatment...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937464/comparison-of-clinical-outcomes-after-anterior-cervical-discectomy-and-fusion-versus-cervical-total-disk-replacement-in-patients-with-modic-2-changes-on-mri
#14
Jia Li, Di Zhang, Wenyuan Ding, Yingze Zhang, Yong Shen
STUDY DESIGN: A retrospective investigation. OBJECTIVE: The aim of this research is to compare the clinical and radiologic outcomes of patients with Modic-2 changes who underwent anterior cervical discectomy and fusion (ACDF) or cervical total disk replacement (TDR) in single level. SUMMARY OF BACKGROUND DATA: There were few studies focused on the clinical and radiologic outcomes of patients with Modic-2 changes who underwent ACDF or cervical TDR in single level...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937463/combined-anterior-posterior-fixation-and-fusion-for-completely-dislocated-hangman-s-fracture-a-retrospective-analysis-of-11-cases
#15
Jianxi Wang, Huajiang Chen, Peng Cao, Wen Yuan, Xiaodong Wu, Gang Liu, Renhu Li, Fazhi Zang, Liangyu Shi, An Wang
STUDY DESIGN: Retrospective clinical study. PURPOSE: To evaluate the effectiveness and feasibility of combined anterior-posterior fixation and fusion for the treatment of completely dislocated hangman's fracture. SUMMARY OF BACKGROUND DATA: A completely dislocated hangman's fracture describes the complete anterior displacement of the C2 vertebral body onto the C3 body. This type of fracture is exceptionally unstable, and for which the management is challenging...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28936836/-molecular-cloning-and-characterization-of-two-kind-of-heat-shock-protein-gene-from-polyporus-umbellatus
#16
Meng-Meng Liu, Yong-Mei Xing, Shun-Xing Guo
With RT-PCR approaches, the full-length cDNA of two heat shock protein genes were cloned from total RNA of the Polyporus umbellatus sclerotium. The full open reading frame cDNA sequence of the Hsp90 was 2 091 bp, encoding 696 amino acid residues with a predicted molecular mass of 78.9 kDa. The full open reading frame cDNA sequence of the Hsp70 was 1 944 bp, encoding 647 amino acid residues with a predicted molecular mass of 70.5 kDa. The Hsp90 and Hsp70 protein contained the conservative structure domain, respectively...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936767/smc-complexes-orchestrate-the-mitotic-chromatin-interaction-landscape
#17
REVIEW
Yasutaka Kakui, Frank Uhlmann
Chromatin is a very long DNA-protein complex that controls the expression and inheritance of the genetic information. Chromatin is stored within the nucleus in interphase and further compacted into chromosomes during mitosis. This process, known as chromosome condensation, is essential for faithful segregation of genomic DNA into daughter cells. Condensin and cohesin, members of the structural maintenance of chromosomes (SMC) family, are fundamental for chromosome architecture, both for establishment of chromatin structure in the interphase nucleus and for the formation of condensed chromosomes in mitosis...
September 21, 2017: Current Genetics
https://www.readbyqxmd.com/read/28936298/the-role-of-leucocyte-rich-and-platelet-rich-fibrin-l-prf-in-the-treatment-of-the-medication-related-osteonecrosis-of-the-jaws-mronj
#18
REVIEW
Jorge A Cano-Durán, Juan-Francisco Peña-Cardelles, Daniel Ortega-Concepción, Víctor M Paredes-Rodríguez, Mariano García-Riart, Juan López-Quiles
BACKGROUND: For the treatment of the bisphosphonates and other drugs related osteonecrosis of the jaws, currently medication-related osteonecrosis of the jaws (MRONJ), have been established different conservative therapeutic approaches, avoiding surgery except in cases of extreme need. Given the controversy and lack of current consensus regarding MRONJ therapy in patients, new techniques have been developed among which the use of fibrin membranes rich in platelets and leukocytes (L-PRF)...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28936282/effect-of-thermocycling-and-surface-treatment-on-repair-bond-strength-of-composite
#19
Nazanin Kiomarsi, Pardis Saburian, Nasim Chiniforush, Mohammad-Javd Karazifard, Sedighe-Sadat Hashemikamangar
BACKGROUND: Repair of composite restorations is a conservative method that can increase the longevity and durability of restorations while preserving the tooth structure. Achieving a suitable bond between the old and new composite is difficult. To overcome this problem, some methods have been recommended to increase the repair bond strength of composite.This study aimed to assess the effect of aging by thermocycling (5,000 and 10,000 cycles) and mechanical surface treatments (Er,Cr:YSGG laser and bur) on repair shear bond strength of composite resin...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28936275/a-bio-inspired-method-for-direct-measurement-of-local-wall-shear-rates-with-micrometer-localization-using-the-multimeric-protein-von-willebrand-factor-as-sensor-molecule
#20
Klaus Bonazza, Bernhard Scheichl, Johannes Frank, Hanspeter Rottensteiner, Gerald Schrenk, Gernot Friedbacher, Peter L Turecek, Friedrich Scheiflinger, Günter Allmaier
Wall shear rates are critical for a broad variety of fluidic phenomena and are taken into account in nearly every experimental or simulation study. Generally, shear rates are not observable directly but rather derived from other parameters such as pressure and flow, often assuming somehow idealized systems. However, there is a biological system which is able to constantly measure the wall shear as a part of a regulatory circuit: The blood circulation system takes advantage of shear rate sensor (protein)molecules (multimeric forms of von Willebrand Factor, VWF), which are dissolved in the blood plasma and dramatically change their conformation under shear conditions...
July 2017: Biomicrofluidics
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