keyword
MENU ▼
Read by QxMD icon Read
search

microsatellites

keyword
https://www.readbyqxmd.com/read/29144791/is-there-a-role-for-programmed-death-ligand-1-testing-and-immunotherapy-in-colorectal-cancer-with-microsatellite-instability-part-i-colorectal-cancer-microsatellite-instability-testing-and-clinical-implications
#1
Esmeralda Celia Marginean, Barbara Melosky
CONTEXT: - Colorectal cancer (CRC) represents the third most-common cancer in developed countries and is a leading cause of cancer deaths worldwide. Two recognized pathways contribute to CRC development: a more-common chromosomal instability pathway and, in 15% of cases, a deficient mismatch repair or microsatellite instability-high (MSI-H) pathway. The MSI-H CRC can be associated with somatic or germline mutations. Microsatellite status has been recognized as a prognostic and predictive biomarker...
November 16, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29143607/features-of-ppd-b1-expression-regulation-and-their-impact-on-the-flowering-time-of-wheat-near-isogenic-lines
#2
Antonina A Kiseleva, Elena K Potokina, Elena A Salina
BACKGROUND: Photoperiod insensitive Ppd-1a alleles determine early flowering of wheat. Increased expression of homoeologous Ppd-D1a and Ppd-A1a result from deletions in the promoter region, and elevated expression of Ppd-B1a is determined by an increased copy number. RESULTS: In this study, using bread wheat cultivars Sonora and PSL2, which contrast in flowering time, and near-isogenic lines resulting from their cross, "Ppd-m" and "Ppd-w" with Ppd-B1a introgressed from Sonora, we investigated the putative factors that influence Ppd-B1a expression...
November 14, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29143146/screening-transferable-microsatellite-markers-across-genus-phalaenopsis-orchidaceae
#3
Ya-Zhu Ko, Huei-Chuan Shih, Chi-Chu Tsai, Hsing-Hua Ho, Pei-Chun Liao, Yu-Chung Chiang
BACKGROUND: Molecular identification based on microsatellite loci is an important technology to improve the commercial breeding of the moth orchid. There are more than 30,000 cultivars have been enrolled at the Royal Horticultural Society (RHS). In this study, genomic microsatellite primer sets were developed from Phalaenopsis aphrodite subsp. formosana to further examine the transferability of across 21 Phalaenopsis species. METHODS AND RESULTS: Twenty-eight polymorphic microsatellite markers were obtained using the magnetic bead enrichment method, with high transferability of the 21 species of the genus Phalaenopsis, especially in the subgenus Phalaenopsis...
November 15, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29143134/reduced-population-size-does-not-affect-the-mating-strategy-of-a-vulnerable-and-endemic-seabird
#4
Cristina Nava, Verónica C Neves, Malvina Andris, Marie-Pierre Dubois, Philippe Jarne, Mark Bolton, Joël Bried
Bottleneck episodes may occur in small and isolated animal populations, which may result in decreased genetic diversity and increased inbreeding, but also in mating strategy adjustment. This was evaluated in the vulnerable and socially monogamous Monteiro's Storm-petrel Hydrobates monteiroi, a seabird endemic to the Azores archipelago which has suffered a dramatic population decline since the XVth century. To do this, we conducted a genetic study (18 microsatellite markers) in the population from Praia islet, which has been monitored over 16 years...
November 15, 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/29143111/correction-to-abstracts-29th-european-congress-of-pathology
#5
M Farinha, J Ribeiro, D Montezuma, A Pires-Luís, P Lopes, H Sousa, L Afonso, R Henrique
In Poster Sessions, the first-author name was missing from the authorship group originally listed for Abstract PS-13-001 (page S176), entitled "Gastric carcinoma with lymphoid stroma: Analysis of microsatellite instability and Epstein-Barr virus status". The correct authorship group is shown above.
November 16, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29138371/-adaptation-of-anti-pd-1-anti-pd-l1-antibody-from-the-viewpoint-of-analysis-of-tumor-microenvironment
#6
Kousaku Mimura, Yuko Nakayama, Tadao Nakazawa, Koji Kono
The response rate of anti-PD-1/anti-PD-L1antibody alone is about 20 to 30%and the development of biomarker for them is important to know their indication. Based on previous reports and our research results, we suggested that basic candidates of biomarker for anti-PD-1/anti-PD-L1antibody are the expression of PD-L1and HLA class I on cancer cells and the invasion of CD8 positive T cells in tumor microenvironment. Furthermore, in addition to these conditions, regulatory T cells and immune cells expressing PD-L1in tumor microenvironment, and microsatellite instability of cancer cells will be considered in the future...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29138079/genetic-structure-and-phenotypic-variation-of-anopheles-darlingi-in-northwest-colombia
#7
Mariano Altamiranda-Saavedra, Jan E Conn, Margarita M Correa
This study evaluated the influence of environmental heterogeneity on Anopheles darlingi genetic and morphometric traits at a microgeographic level. Specimens of An. darlingi collected from multiple municipalities in the Colombian malaria endemic region Urabá-Bajo Cauca and Alto Sinú (UCS) were analyzed using 13 microsatellite loci. Spatial genetic structure, population variation and wing geometric morphometric analyses were performed. Microsatellite results showed low genetic differentiation and high gene flow among populations; four highly admixed subpopulations were detected with no particular association to the municipalities...
November 11, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29137623/analysis-of-factors-influencing-molecular-testing-at-diagnostic-of-colorectal-cancer
#8
Quentin Thiebault, Gautier Defossez, Lucie Karayan-Tapon, Pierre Ingrand, Christine Silvain, David Tougeron
BACKGROUND: The aim of the study was to evaluate the current rate of molecular testing prescription (KRAS codons 12/13, BRAF and microsatellite instability (MSI)) in newly diagnosed colorectal cancer (CRC) patients and to determine which factors influence testing. METHODS: All incident CRC cases in 2010 were identified in the Poitou-Charentes General Cancer Registry. The exhaustive molecular testing performed was accessed in the French molecular genetics platform...
November 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29137273/programmed-death-ligand-1-and-met-co-expression-is-a-poor-prognostic-factor-in-gastric-cancers-after-resection
#9
Mi Jung Kwon, Kab-Choong Kim, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Hye Kyung Lee, Ho Suk Kang, Kyueng-Whan Min
Programmed death-ligand 1 (PD-L1) plays an essential protein for immune evasion, contributing to tumor development and progression. Recent studies have reported MET as an upregulator for PD-L1 overexpression through an oncogenic pathway. However, an association between PD-L1 expression with MET has not been reported in gastric cancer.The prognostic significance of PD-L1 and its association with Epstein-Barr virus (EBV), microsatellite instability (MSI), and mucin phenotype remain controversial. We performed in situ hybridization for EBV-encoded RNA and immunohistochemistry in tissue microarrays for 394 gastric cancers...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136171/mating-system-and-effective-population-size-of-the-overexploited-neotropical-tree-myroxylon-peruiferum-l-f-and-their-impact-on-seedling-production
#10
Ellida de Aguiar Silvestre, Kaiser Dias Schwarcz, Carolina Grando, Jaqueline Bueno de Campos, Patricia Sanae Sujii, Evandro Vagner Tambarussi, Camila Menezes Trindade Macrini, José Baldin Pinheiro, Pedro Henrique Santin Brancalion, Maria Imaculada Zucchi
The reproductive system of a tree species has substantial impact on genetic diversity and structure within and among natural populations. Such information, should be considered when planning tree planting for forest restoration. Here, we describe the mating system and genetic diversity of an overexploited Neotropical tree, Myroxylon peruiferum L.f. (Fabaceae) sampled from a forest remnant (10 seed trees and 200 seeds) and assess whether the effective population size of nursery-grown seedlings (148 seedlings) is sufficient to prevent inbreeding depression in reintroduced populations...
November 10, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29134724/biogeography-of-mutualistic-fungi-cultivated-by-leafcutter-ants
#11
Ulrich G Mueller, Heather D Ishak, Sofia M Bruschi, Chad C Smith, Jacob J Herman, Scott E Solomon, Alexander S Mikheyev, Christian Rabeling, Jarrod J Scott, Michael Cooper, Andre Rodrigues, Adriana Ortiz, Carlos Roberto F Brandão, John E Lattke, Fernando C Pagnocca, Stephen A Rehner, Ted R Schultz, Heraldo L Vasconcelos, Rachelle M M Adams, Martin Bollazzi, Rebecca M Clark, Anna G Himler, John S LaPolla, Inara R Leal, Robert A Johnson, Flavio Roces, Jeffrey Sosa-Calvo, Rainer Wirth, Maurício Bacci
Leafcutter ants propagate co-evolving fungi for food. The nearly 50 species of leafcutter ants (Atta, Acromyrmex) range from Argentina to the USA, with the greatest species diversity in southern South America. We elucidate the biogeography of fungi cultivated by leafcutter ants using DNA-sequence and microsatellite-marker analyses of 474 cultivars collected across the leafcutter range. Fungal cultivars belong to two clades (Clade-A, Clade-B). The dominant and widespread Clade-A cultivars form three genotype-clusters, with their relative prevalence corresponding to southern South America, northern South America, and Central & North America...
November 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29133367/regulatory-t-cell-genes-drive-altered-immune-microenvironment-in-adult-solid-cancers-and-allow-for-immune-contextual-patient-subtyping
#12
Jurriaan Brouwer-Visser, Wei-Yi Cheng, Anna Bauer-Mehren, Daniela Maisel, Katharina Lechner, Emilia Andersson, Joel T Dudley, Francesca Milletti
BACKGROUND: The tumor microenvironment is an important factor in cancer immunotherapy response. To further understand how a tumor affects the local immune system, we analyzed immune gene expression differences between matching normal and tumor tissue. METHODS: We analyzed public and new gene expression data from solid cancers and isolated immune cell populations. We also determined the correlation between CD8, FoxP3 immunohistochemistry (IHC) and our gene signatures...
November 13, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29132298/population-genetic-structure-is-shaped-by-historical-geographic-and-environmental-factors-in-the-leguminous-shrub-caragana-microphylla-on-the-inner-mongolia-plateau-of-china
#13
Bo Xu, Guoli Sun, Xuemin Wang, Jingwei Lu, Ian J Wang, Zan Wang
BACKGROUND: Understanding how landscape factors, including suites of geographic and environmental variables, and both historical and contemporary ecological and evolutionary processes shape the distribution of genetic diversity is a primary goal of landscape and conservation genetics and may be particularly consequential for species involved in ecological restoration. In this study, we examine the factors that shape the distribution of genetic variation in a leguminous shrub (Caragana microphylla) important for restoration efforts on the Mongolian Plateau in China...
November 13, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29128931/universal-determination-of-microsatellite-instability-using-bat26-as-a-single-marker-in-an-argentine-colorectal-cancer-cohort
#14
María Laura González, Natalia Causada-Calo, Juan Pablo Santino, Mev Dominguez-Valentin, Fabiana Alejandra Ferro, Inés Sammartino, Pablo Germán Kalfayan, Maria Alicia Verzura, Tamara Alejandra Piñero, Andrea Romina Cajal, Walter Pavicic, Carlos Vaccaro
Microsatellite instability (MSI) is a hallmark tool for Lynch syndrome (LS) screening and a prognostic marker for sporadic colorectal cancer (CRC). In regions with limited resources and scarce CRC molecular characterization as South America, the implementation of universal MSI screening is under debate for both its purposes. We sought to estimate the frequency of BAT26 in colorectal adenocarcinomas and to determine associated clinical and histological features. Consecutive patients from a CRC registry were included...
November 11, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29127523/identification-of-quantitative-trait-loci-for-resistance-to-rsivd-in-red-sea-bream-pagrus-major
#15
Eitaro Sawayama, Shiho Tanizawa, Shin-Ichi Kitamura, Kei Nakayama, Kohei Ohta, Akiyuki Ozaki, Motohiro Takagi
Red sea bream iridoviral disease (RSIVD) is a major viral disease in red sea bream farming in Japan. Previously, we identified one candidate male individual of red sea bream that was significantly associated with convalescent individuals after RSIVD. The purpose of this study is to identify the quantitative trait loci (QTL) linked to the RSIVD-resistant trait for future marker-assisted selection (MAS). Two test families were developed using the candidate male in 2014 (Fam-2014) and 2015 (Fam-2015). These test families were challenged with RSIV, and phenotypes were evaluated...
November 10, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/29127392/saccharomycesidentifier-sid-strain-level-analysis-of-saccharomyces-cerevisiae-populations-by-using-microsatellite-meta-patterns
#16
Irene Stefanini, Davide Albanese, Maddalena Sordo, Jean-Luc Legras, Carlotta De Filippo, Duccio Cavalieri, Claudio Donati
Saccharomyces cerevisiae is a common yeast with several applications, among which the most ancient is winemaking. Because individuals belonging to this species show a wide genetic and phenotypic variability, the possibility to identify the strains driving fermentation is pivotal when aiming at stable and palatable products. Metagenomic sequencing is increasingly used to decipher the fungal populations present in complex samples such as musts. However, it does not provide information at the strain level. Microsatellites are commonly used to describe the genotype of single strains...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126141/gastric-carcinomas-with-lymphoid-stroma-categorization-and-comparison-with-solid-type-colonic-carcinomas
#17
Raul S Gonzalez, Justin M M Cates, Frank Revetta, Loralee A McMahon, Kay Washington
Objectives: To determine whether histologic features could help identify gastric carcinomas with lymphoid stroma associated with microsatellite instability (MSI) (ie, "medullary carcinomas"), Epstein-Barr virus (EBV) infection (termed lymphoepithelioma-like carcinomas in other organ systems), or neither. Methods: We identified 17 solid-type gastric carcinomas with lymphoid stroma, assessed EBV and MSI status, and compared features across groups. We also compared them with 51 solid-type colorectal adenocarcinomas...
November 8, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29124846/prevalence-mechanisms-and-genetic-relatedness-of-the-human-pathogenic-fungus-aspergillus-fumigatus-exhibiting-resistance-to-medical-azoles-in-the-environment-of-taiwan
#18
Hsuan-Chen Wang, Jui-Chang Huang, Yong-Hong Lin, Yu-Hsin Chen, Ming-I Hsieh, Pui-Ching Choi, Hsiu-Jung Lo, Wei-Lun Liu, Ching-Shan Hsu, Hsin-I Shih, Chi-Jung Wu, Yee-Chun Chen
Emerging azole resistance in Aspergillus fumigatus poses a serious threat to human health. This nationwide surveillance study investigated the prevalence and molecular characteristics of azole-resistant A. fumigatus environmental isolates in Taiwan, an island country with increasing use of azole fungicides. Of the 2,760 air and soil samples screened from 2014-2016, 451 A. fumigatus isolates were recovered from 266 samples, and 34 isolates from 29 samples displayed resistance to medical azoles (itraconazole, voriconazole, or posaconazole)...
November 10, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29124392/tracking-the-evolutionary-pathway-of-sex-chromosomes-among-fishes-characterizing-the-unique-xx-xy1y2-system-in-hoplias-malabaricus-teleostei-characiformes
#19
Ezequiel Aguiar de Oliveira, Alexandr Sember, Luiz Antonio Carlos Bertollo, Cassia Fernanda Yano, Tariq Ezaz, Orlando Moreira-Filho, Terumi Hatanaka, Vladimir Trifonov, Thomas Liehr, Ahmed Basheer Hamid Al-Rikabi, Petr Ráb, Hugmar Pains, Marcelo de Bello Cioffi
The Neotropical fish, Hoplias malabaricus, is one of the most cytogenetically studied fish taxon with seven distinct karyomorphs (A-G) comprising varying degrees of sex chromosome differentiation, ranging from homomorphic to highly differentiated simple and multiple sex chromosomes. Therefore, this fish offers a unique opportunity to track evolutionary mechanisms standing behind the sex chromosome evolution and differentiation. Here, we focused on a high-resolution cytogenetic characterization of the unique XX/XY1Y2 multiple sex chromosome system found in one of its karyomorphs (G)...
November 9, 2017: Chromosoma
https://www.readbyqxmd.com/read/29124284/ca-2-nuclear-factor-of-activated-t-cells-signaling-is-enriched-in-early-onset-rectal-tumors-devoid-of-canonical-wnt-activation
#20
Raju Kumar, Ratheesh Raman, Viswakalyan Kotapalli, Swarnalata Gowrishankar, Saumyadipta Pyne, Jonathan R Pollack, Murali D Bashyam
Our previous extensive analysis revealed a significant proportion of early-onset colorectal tumors from India to be localized to the rectum in younger individuals and devoid of deregulated Wnt/β-catenin signaling. In the current study, we performed a comprehensive genome-wide analysis of clinically well-annotated microsatellite stable early-onset sporadic rectal cancer (EOSRC) samples. Results revealed extensive DNA copy number alterations in rectal tumors in the absence of deregulated Wnt/β-catenin signaling...
November 9, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
keyword
keyword
43465
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"