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https://www.readbyqxmd.com/read/28224680/aberrant-expressions-of-endometrial-id3-and-ctla-4-are-associated-with-unexplained-repeated-implantation-failure-and-recurrent-miscarriage
#1
Jin-Li Ding, Liang-Hui Diao, Tai-Lang Yin, Chun-Yu Huang, Biao Yin, Cong Chen, Yi Zhang, Jie Li, Yan-Xiang Cheng, Yong Zeng, Jing Yang
Inhibitor of DNA-binding protein 3 (Id3) is required for tumor angiogenesis and regulatory T-cell generation. However, the involvement of Id3 in unexplained repeated implantation failure (RIF) and recurrent miscarriage (RM) remains poorly understood. Immunohistochemistry was used to identify Id3, CD34, CTLA-4, and FOXP3 in the endometrium taken from the women with RIF (n=16), RM (n=16) and matched controls (n=8). The images were acquired and analyzed by the Vectra(®) automated quantitative pathology imaging system...
February 21, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28223455/acute-fetal-demise-with-first-trimester-maternal-infection-resulting-from-listeria-monocytogenes-in-a-nonhuman-primate-model
#2
Bryce Wolfe, Gregory J Wiepz, Michele Schotzko, Gennadiy I Bondarenko, Maureen Durning, Heather A Simmons, Andres Mejia, Nancy G Faith, Emmanuel Sampene, Marulasiddappa Suresh, Sophia Kathariou, Charles J Czuprynski, Thaddeus G Golos
Infection with Listeria monocytogenes during pregnancy is associated with miscarriage, preterm birth, and neonatal complications, including sepsis and meningitis. While the risk of these conditions is thought to be greatest during the third trimester of pregnancy, the determinants of fetoplacental susceptibility to infection, the contribution of gestational age, and the in vivo progression of disease at the maternal-fetal interface are poorly understood. We developed a nonhuman primate model of listeriosis to better understand antecedents of adverse pregnancy outcomes in early pregnancy...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28218216/effects-of-previous-laparoscopic-surgical-diagnosis-of-endometriosis-on-pregnancy-outcomes
#3
Hui Li, Hong-Lan Zhu, Xiao-Hong Chang, Yi Li, Yue Wang, Jing Guan, Heng Cui
BACKGROUND: The association between the previous history of endometriosis and obstetric outcomes is still ambiguous. This study aimed to evaluate the effects of previous history of operatively diagnosed endometriosis on pregnancy outcomes. METHODS: A total of 98 primiparous women who had been diagnosed with endometriosis by previous laparoscopic surgery were included in this retrospective cohort study. Pregnancy outcomes were compared between these women (study group) who had a live birth and 300 women without endometriosis (control group) who had a live birth...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28216909/aneuploidy-screening-by-array-comparative-genomic-hybridization-improves-success-rates-of-in-vitro-fertilization-a-multicenter-indian-study
#4
Aditi Kotdawala, Deven Patel, Javier Herrero, Rajni Khajuria, Nalini Mahajan, Manish Banker
OBJECTIVE: To evaluate the usefulness of preimplantation genetic screening (PGS) using array comparative genomic hybridization (aCGH) in the Indian population. MATERIALS AND METHODS: This is a retrospective, multicenter study including 235 PGS cycles following intracytoplasmic sperm injection performed at six different infertility centers from September 2013 to June 2015. Patients were divided as per maternal age in several groups (<35, 35-36, 37-38, 39-40, and >40 years) and as per indication for undergoing PGS...
October 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28214760/genotyping-analysis-of-protein-s-tokushima-k196e-and-the-involvement-of-protein-s-antigen-and-activity-in-patients-with-recurrent-pregnancy-loss
#5
Yasushi Matsukawa, Eriko Asano, Tomohide Tsuda, Hiroyuki Kuma, Tamao Kitaori, Kinue Katano, Yasuhiko Ozaki, Mayumi Sugiura-Ogasawara
OBJECTIVE: Preston et al. indicated that Protein S (PS) deficiency was associated with stillbirths but not miscarriages. The PS-Tokushima missense variant was reported to serve as a genetic risk factor for deep vein thrombosis in the Japanese population. A previous cross-sectional study showed no increase in the prevalence of PS-Tokushima in patients with recurrent early pregnancy loss or in patients with intra uterine fetal death and/or fetal growth restriction. There has been limited number of prospective studies examining the pregnancy outcome in patients with both a PS deficiency and recurrent pregnancy loss (RPL)...
February 8, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28211552/incidence-of-postpartum-depression-and-couple-relationship-quality
#6
Aleksandra Małus, Justyna Szyluk, Beata Galińska-Skok, Beata Konarzewska
OBJECTIVES: The childbirth constitutes a significant event in a woman's life and in the marital/ couple dyad. The changes which follow childbirth require re-organization of previous coping styles and development of new methods of adaptation, which proves difficult. The current study evaluated to what extent the development of postpartum depression symptoms in new mothers was associated with their level of satisfaction in marital relationship. METHODS: The study included 100 women in their first month after delivery...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28211357/preimplantation-genetic-diagnosis-and-screening-by-array-comparative-genomic-hybridisation-experience-of-more-than-100-cases-in-a-single-centre
#7
J Fc Chow, W Sb Yeung, V Cy Lee, E Yl Lau, P C Ho, E Hy Ng
INTRODUCTION: Preimplantation genetic screening has been proposed to improve the in-vitro fertilisation outcome by screening for aneuploid embryos or blastocysts. This study aimed to report the outcome of 133 cycles of preimplantation genetic diagnosis and screening by array comparative genomic hybridisation. METHODS: This study of case series was conducted in a tertiary assisted reproductive centre in Hong Kong. Patients who underwent preimplantation genetic diagnosis for chromosomal abnormalities or preimplantation genetic screening between 1 April 2012 and 30 June 2015 were included...
February 17, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28210092/first-successful-perinatal-management-of-pregnancy-after-abo-incompatible-liver-transplantation
#8
Hisanobu Higashi, Hideaki Obara, Kei Miyakoshi, Masahiro Shinoda, Minoru Kitago, Naoki Shimojima, Yuta Abe, Taizo Hibi, Hiroshi Yagi, Kentaro Matsubara, Yohei Yamada, Osamu Itano, Ken Hoshino, Tatsuo Kuroda, Yuko Kitagawa
Many papers have reported on pregnancy and delivery after liver transplantation, but there have been no reports on pregnancy after ABO-incompatible liver transplantation. This paper reports the first successful pregnancy and delivery of a newborn after ABO-incompatible liver transplantation for fulminant hepatic failure. The patient was a 39-year-old female. She had an ABO-incompatible liver transplantation, donated from her husband, due to subacute fulminant hepatitis of unknown etiology. She was taking tacrolimus, methylprednisolone, and mizoribine orally for the maintenance of immunosuppression at the time of discharge...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28209537/misorest-surgical-versus-expectant-management-in-women-with-an-incomplete-evacuation-of-the-uterus-after-misoprostol-treatment-for-miscarriage-a-cohort-study
#9
Marike Lemmers, Marianne A C Verschoor, Katrien Oude Rengerink, Christiana Naaktgeboren, Patrick M Bossuyt, Judith A F Huirne, Ineke A H Janssen, Celine Radder, Ellen R Klinkert, Josje Langenveld, Lucet van der Voet, F Frederike Siemens, Marlies Y Bongers, Marcel H van Hooff, Marinus van der Ploeg, F P J Sjors, S F P J Coppus, W M Ankum, Ben Willem J Mol
OBJECTIVE: To assess the effectiveness of curettage versus expectant management in women with an incomplete evacuation of the uterus after misoprostol treatment for first trimester miscarriage. STUDY DESIGN: We conducted a multicenter cohort study alongside a randomized clinical trial (RCT) between June 2012 until July 2014. 27 Dutch hospitals participated. Women with an incomplete evacuation after misoprostol treatment for first trimester miscarriage who declined to participate in the RCT, received treatment of their preference; curettage (n=65) or expectant management (n=132)...
January 27, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28208880/balanced-autosomal-translocations-in-two-women-reporting-recurrent-miscarriage
#10
Brindha Arumugam, Chandra R Samuel, Santhiya Sathiyavedu Thyagarajan
Spontaneous abortion or loss of fetus prior to 20 weeks of gestation is observed in 15-20% of clinically recognized pregnancies. Recurrent Miscarriage (RM) is defined as three or more consecutive pregnancy losses and it affects 1-2% of women. Parental chromosomal rearrangements account for 2-5% of RM. This report describes two couples with a clinical history of RM who were subjected to conventional cytogenetic analysis to ascertain the chromosomal aetiology. Analysis of GTG-banded metaphases obtained from cultured lymphocytes at approximately 500-band resolution revealed balanced translocation in the female spouses as 46,XX,t(8;11)(p11...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207749/determinants-of-first-trimester-attendance-at-antenatal-care-clinics-in-the-amazon-region-of-peru-a-case-control-study
#11
Nora Moore, Brittany Blouin, Hugo Razuri, Martin Casapia, Theresa W Gyorkos
OBJECTIVE: To identify determinants which influence the timing of the first antenatal care (ANC) visit in pregnant women. DESIGN: Retrospective matched nested case-control study. SETTING: Two health centres, Belén and 6 de Octubre, in the Peruvian Amazon. POPULATION: All pregnant women who had attended ANC during the years 2010, 2011, and 2012. METHODS: All cases (819 women initiating ANC in their first trimester) were selected from ANC registries from 2010 to 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28207498/an-analysis-of-variations-of-indications-and-maternal-fetal-prognosis-for-caesarean-section-in-a-tertiary-hospital-of-beijing-a-population-based-retrospective-cohort-study
#12
Yajun Liu, Xin Wang, Liying Zou, Yan Ruan, Weiyuan Zhang
In recent decades, we have observed a remarkable increase in the rate of caesarean section (CS) in both developed and developing countries, especially in China. According to the World Health Organization (WHO) systematic review, if the increase in CS rate was between 10% and 15%, the maternal and neonatal mortality was decreased. However, above this level, increasing the rate of CS is no longer associated with reduced mortality. To date, no consensus has been reached on the main factors driving the cesarean epidemic...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28199872/fertility-and-obstetric-outcomes-after-curettage-versus-expectant-management-in-randomised-and-non-randomised-women-with-an-incomplete-evacuation-of-the-uterus-after-misoprostol-treatment-for-miscarriage
#13
M Lemmers, M A C Verschoor, K Overwater, P M Bossuyt, D Hendriks, M Hemelaar, J M Schutte, A H Adriaanse, W M Ankum, J A F Huirne, B W J Mol
OBJECTIVE: To assess fertility and obstetric outcomes in women treated with curettage or undergoing expectant management for an incomplete miscarriage after misoprostol treatment. STUDY DESIGN: Between June 2012 and July 2014, we conducted a multicentre randomised clinical trial (RCT) with a parallel cohort study for non-randomised women, treated according to their preference. In the RCT 30 women were allocated curettage and 29 expectant management. In the cohort 197 women participated; 65 underwent curettage and 132 women underwent expectant management...
January 30, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28196715/safety-of-the-oral-cholera-vaccine-in-pregnancy-retrospective-findings-from-a-subgroup-following-mass-vaccination-campaign-in-dhaka-bangladesh
#14
Ashraful Islam Khan, Mohammad Ali, Fahima Chowdhury, Amit Saha, Iqbal Ansary Khan, Arifuzzaman Khan, Afroza Akter, Muhammad Asaduzzaman, Md Taufiqul Islam, Alamgir Kabir, Young Ae You, Nirod Chandra Saha, Alejandro Cravioto, John D Clemens, Firdausi Qadri
BACKGROUND: Pregnant women are vulnerable to complications of cholera. Killed oral cholera vaccines (OCV) are not recommended for pregnant women though there is no evidence of harmful effects during pregnancy. We evaluated the effect of a killed OCV, Shanchol™, on pregnancy outcomes during an effectiveness trial of the vaccine in urban Bangladesh. METHODOLOGY: Individuals ⩾1year were invited to participate in the trial, conducted in 2011 in Dhaka, Bangladesh...
February 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28193831/%C3%AE-2-glycoprotein-i-recognition-drives-th1-inflammation-in-atherosclerotic-plaques-of-patients-with-primary-antiphospholipid-syndrome
#15
Marisa Benagiano, Maria Gerosa, Jacopo Romagnoli, Michael Mahler, Maria O Borghi, Alessia Grassi, Chiara Della Bella, Giacomo Emmi, Amedeo Amedei, Elena Silvestri, Lorenzo Emmi, Domenico Prisco, Pier Luigi Meroni, Mario M D'Elios
Antiphospholipid syndrome (APS) is characterized by recurrent arterial/venous thrombosis and miscarriages in the persistent presence of autoantibodies against phospholipid-binding proteins (aPLs), such as β2 glycoprotein I (β2GPI). In addition to the aPL thrombophilic effect, arterial thrombosis was related to accelerated atherosclerosis in animal models; however, contrasting findings were reported in primary APS patients with regard to the increased number of plaques or abnormal arterial wall thickness. We investigated the cytokine production induced by β2GPI in activated T cells that infiltrate in vivo atherosclerotic lesions of primary APS patients with atherothrombosis...
February 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28193233/tacrolimus-in-the-prevention-of-adverse-pregnancy-outcomes-and-diabetes-associated-embryopathies-in-obese-and-diabetic-mice
#16
Ahmad J H Albaghdadi, Melanie A Hewitt, Samantha M Putos, Michael Wells, Terence R S Ozolinš, Frederick W K Kan
BACKGROUND: T2DM is a high-risk pregnancy with adverse fetal and maternal outcomes including repeated miscarriages and fetal malformations. Despite the established association between placental insufficiency and poor maternal Th1-adaptability to the development of pregnancy complications in T2DM, there have been no established data to assess benefits of pre-pregnancy immunosuppression relative to gestational outcomes in T2DM. We hypothesized that pre-pregnancy macrolide immune suppression can re-establish normal placental development and uterine vascular adaptation in a mouse model of obesity-associated T2DM...
February 13, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28188146/abortion-and-fertility-control-in-pakistan-the-role-of-misoprostol
#17
Harneet Chahal, Zubia Mumtaz
OBJECTIVE: To examine how availability of misoprostol has impacted women's abortion-seeking behaviour in Pakistan. DESIGN: Focused ethnography. SETTING: A facility providing reproductive health services, including induced abortions in Chakwal, a small town in Northern Punjab, Pakistan. POPULATION: Women who came to the clinic seeking an abortion or who had had one in the last 6 months (n=23) and all healthcare providers working in the facility (n=14)...
February 10, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28186601/-analysis-of-the-cause-of-pregnancy-failure-with-combined-mlpa-assay-for-subtelomeric-regions-and-ultrasonography
#18
Ying Zhao, Jiwu Lou, Manna Sun, Youqing Fu, Yanhui Liu
OBJECTIVE: To explore the value of multiplex ligation-dependent probe amplification (MLPA) for the detection of chromosome abnormalities in miscarriage tissues, and to correlate the result with ultrasound findings. METHODS: A total of 421 cases of spontaneous abortions and fetal deaths were detected with the MLPA method. RESULTS: Among the 421 samples, 232 (55.11%) had an abnormal MLPA result. For the 286 cases derived from < 13 weeks pregnancy, 206 (72...
February 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28186187/factors-associated-with-aberrant-imprint-methylation-and-oligozoospermia
#19
Norio Kobayashi, Naoko Miyauchi, Nozomi Tatsuta, Akane Kitamura, Hiroaki Okae, Hitoshi Hiura, Akiko Sato, Takafumi Utsunomiya, Nobuo Yaegashi, Kunihiko Nakai, Takahiro Arima
Disturbingly, the number of patients with oligozoospermia (low sperm count) has been gradually increasing in industrialized countries. Epigenetic alterations are believed to be involved in this condition. Recent studies have clarified that intrinsic and extrinsic factors can induce epigenetic transgenerational phenotypes through apparent reprogramming of the male germ line. Here we examined DNA methylation levels of 22 human imprinted loci in a total of 221 purified sperm samples from infertile couples and found methylation alterations in 24...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183871/y-chromosome-polymorphisms-may-contribute-to-an-increased-risk-of-male-induced-unexplained-recurrent-miscarriage
#20
Yan Wang, Gang Li, Man-Zhen Zuo, Hai-Rong Li, Jun-Hua Fang, Dan-Dan Quan, Lu Huang, Ping-Ping Peng
Objective: This study aims to explore the relationship between the Y chromosome polymorphisms (1qh+, inv(9), 9qh+, 16qh+, group D/G, Yqh- and Yqh+) and the risk of unexplained recurrent miscarriage (URM).Methods: A total of 507 couples with URM were recruited as case group and 465 healthy couples as control group. The Y chromosome polymorphisms of the male individuals were analyzed with the G-banding technique, and the results of the chromosome G-banding analysis were determined using the International Naming Standards of Human Genetics (ISCN)...
February 9, 2017: Bioscience Reports
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