Jana Grune, Geetika Bajpai, Pervin Tülin Ocak, Eva Kaufmann, Kyle Mentkowksi, Steffen Pabel, Nina Kumowski, Fadi E Pulous, Kim A Tran, David Rohde, Shuang Zhang, Yoshiko Iwamoto, Gregory R Wojtkiewicz, Claudio Vinegoni, Ursula Green, Filip K Swirski, James R Stone, Jochen K Lennerz, Maziar Divangahi, Maarten Hulsmans, Matthias Nahrendorf
BACKGROUND: Viral infections can cause acute respiratory distress syndrome (ARDS), systemic inflammation, and secondary cardiovascular complications. Lung macrophage subsets change during ARDS, but the role of heart macrophages in cardiac injury during viral ARDS remains unknown. Here we investigate how immune signals typical for viral ARDS affect cardiac macrophage subsets, cardiovascular health, and systemic inflammation. METHODS: We assessed cardiac macrophage subsets using immunofluorescence histology of autopsy specimens from 21 patients with COVID-19 with SARS-CoV-2-associated ARDS and 33 patients who died from other causes...
March 20, 2024: Circulation