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https://www.readbyqxmd.com/read/29790401/translational-gaps-in-animal-models-of-human-infusion-reactions-to-nanomedicines
#1
S Moein Moghimi, Dmitri Simberg
Adverse infusion reactions to regulatory approved nanomedicines in human subjects are idiosyncratic, but outwardly reproducible in pigs. A large body of evidence suggests that the porcine reactions are related to robust nanoparticle clearance by pulmonary intravascular macrophages (PIMs), and rapid release of arachidonate metabolites from these cells. Similar to pigs, other animals that have resident PIMs in their lungs also respond to intravenously injected particles, where rapid particle clearance by PIMs correlate with peak periods of cardiopulmonary distress...
May 2018: Nanomedicine
https://www.readbyqxmd.com/read/29785974/railway-noise-annoyance-on-the-railway-track-in-northwest-slovakia
#2
Alzbeta Pultznerova, Panulinova Eva, Daniela Kucharova, Lubica Argalasova
Introduction: This paper describes an assessment of noise caused by railway traffic in a large high-loaded railway track in Northwest Slovakia. Materials and Methods: The measurements of noise levels generated by trains passing through residential neighborhoods were taken. Noise maps were also calculated showing noise pollution generated by the train traffic. In addition, the annoyance level and sleep disturbance of residents affected by railway noise were evaluated by a validated questionnaire on a pilot sample of 107 respondents living near the important railway track...
May 2018: Noise & Health
https://www.readbyqxmd.com/read/29785228/evaluating-the-utility-of-a-structured-clinical-protocol-for-reducing-the-impact-of-behavioural-and-psychological-symptoms-of-dementia-in-progressive-neurological-diseases-a-pilot-study
#3
Nicholas P Ryan, Laura Scott, Maryanne McPhee, Susan Mathers, Marie-Claire Davis, Roxanne Maule, Fiona Fisher
Objectives: Behavioural and psychological symptoms of dementia (BPSD) cause significant distress to both aged care residents and staff. Despite the high prevalence of BPSD in progressive neurological diseases (PNDs) such as multiple sclerosis, Huntington's disease, and Parkinson's disease, the utility of a structured clinical protocol for reducing BPSD has not been systematically evaluated in PND populations. Method: Staff ( n = 51) and individuals with a diagnosis of PND ( n = 13) were recruited into the study, which aimed to evaluate the efficacy of a PND-specific structured clinical protocol for reducing the impact of BPSD in residential aged care (RAC) and specialist disability accommodation (SDA) facilities...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29761286/a-qualitative-analysis-of-stress-and-relaxation-themes-contributing-to-burnout-in-first-year-psychiatry-and-medicine-residents
#4
Nicole M Benson, Deanna Chaukos, Heather Vestal, Emma F Chad-Friedman, John W Denninger, Christina P C Borba
OBJECTIVE: Qualitative research on trainee well-being can add nuance to the understanding of propagators of burnout, and the role for interventions aimed at supporting well-being. This qualitative study was conducted to identify (i) situations and environments that cause stress for trainees, (ii) stress-reducing activities that trainees utilize, and (iii) whether trainees who report distress (high burnout and depression scores) describe different stressors and relaxation factors than those who do not...
May 14, 2018: Academic Psychiatry
https://www.readbyqxmd.com/read/29760607/association-between-bmi-for-obesity-and-distress-about-appearance-in-korean-adolescents
#5
Hyo Geun Choi, Hyoseob Lim
Background: Previous research has related obesity to body dissatisfaction and low self-esteem. This study aimed to evaluate this relation between obesity and distress about appearance. Methods: We performed a cross-sectional study using data from the Korea Youth Risk Behavior Web-based Survey for 288,390 participants assessed from 2009 to 2012. The participants were categorized according to body mass index; obese, overweight, healthy weight, and underweight. The relation between obesity and distress was analyzed using simple and multiple logistic regression with complex sampling adjusted for age, sex, region of residence, economic level, parental education level, alcohol consumption, and smoking habits as confounders...
May 14, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29757044/comparison-of-mental-health-outcomes-among-adults-with-psoriasis-on-biologic-versus-oral-therapies-a-population-based-study
#6
Nicole Salame, Nazanin Ehsani-Chimeh, April W Armstrong
PURPOSE: We sought to compare the impact of biologic versus oral therapies on mental health outcomes among adult U.S. residents with moderate-to-severe psoriasis. METHODS: We performed a nationwide, cross-sectional study comparing 2,303,534 (weighted) adults with moderate-to-severe psoriasis on biologic versus oral therapies and their associated mental health outcomes using the 2003-2015 Medical Expenditure Panel Survey (MEPS). Mental health outcomes were measured with the Kessler 6 (K6), a validated measure of psychological distress, and Patient Health Questionnaire 2 (PHQ2), a screening tool for depression...
May 14, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29753161/engagement-with-inspire-an-online-program-for-hematopoietic-cell-transplantation-survivors
#7
Karen L Syrjala, Marie-Laure Crouch, Wendy M Leisenring, Mary E D Flowers, Samantha B Artherholt, Allison Stover Fiscalini, Eleni Romano, Joan M Romano, Paul J Martin, Jean C Yi
PURPOSE: In a secondary analysis of a randomized controlled trial (RCT), we examined engagement with INSPIRE, a personalized online program for hematopoietic cell transplantation (HCT) survivors that focused on cancer-related distress, depression, fatigue, and health care needs. METHODS: We approached all adult, 3-18 year HCT survivors treated for hematologic malignancy, without relapse or second cancer in the previous 2 years, for participation in an RCT with either immediate or delayed access to INSPIRE...
May 9, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29746552/the-impact-of-being-bullied-at-school-on-psychological-distress-and-work-engagement-in-a-community-sample-of-adult-workers-in-japan
#8
Mai Iwanaga, Kotaro Imamura, Akihito Shimazu, Norito Kawakami
OBJECTIVE: The aim of this study was to investigate the long-term impact of being bullied at school on current psychological distress and work engagement in adulthood among Japanese workers. We hypothesized that workers who had been bullied at school could have higher psychological distress and lower work engagement compared to those who had not been bullied. METHODS: We used data from the Japanese Study on Stratification, Health, Income, and Neighborhood (J-SHINE) project, conducted from July 2010 to February 2011 in Japan...
2018: PloS One
https://www.readbyqxmd.com/read/29746377/risk-factors-for-severe-community-acquired-pneumonia-among-children-hospitalized-with-cap-younger-than-5-years-of-age
#9
Wei Shan, Ting Shi, Kaile Chen, Jian Xue, Yin Wang, Jia Yu, Genming Zhao, Jianmei Tian, Tao Zhang
BACKGROUND: CAP causes great morbidity and mortality as well as enormous economic burden worldwide. This study intended to describe the clinical characteristics of CAP and explore the risk factors of severe CAP among children in downtown Suzhou, China. METHODS: This was a retrospective study of childhood hospitalizations in Soochow University Affiliated Children's Hospital (SCH) from January 1, 2010 to December 31, 2014. Children who were residents of downtown Suzhou, 29 days to <5 years of age, with discharge diagnosis codes (ICD-10) J09 to J18 and J20 to J22 were included...
May 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29736069/alcohol-harm-to-adolescents-from-others-drinking-a-study-from-kerala-india
#10
T S Jaisoorya, K V Beena, G S Ravi, K Thennarasu, Vivek Benegal
Context: There is scarce data on the prevalence of harm to adolescents from others' use of alcohol from India. Aims: The aim is to study the prevalence of harm to school students from others' alcohol use in the district of Ernakulam, Kerala and examines its psychosocial correlates among victims. Settings and Design: This was a cross-sectional survey of 7560 students of the age range of 12-19 years from 73 schools. Materials and Methods: Harm consequent to others' drinking was assessed using a brief version of the World Health Organization-Thai Health Questionnaire on Harm to Others from Drinking...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29735902/the-challenges-of-predicting-suicidal-thoughts-and-behaviours-in-a-sample-of-rural-australians-with-depression
#11
Tonelle Handley, Jane Rich, Kate Davies, Terry Lewin, Brian Kelly
Suicide is a leading cause of death, particularly in rural and remote areas. Although depression is strongly related to both suicidal ideation and attempt, it lacks specificity as a predictor, and little is known about characteristics that increase suicide risk among people with depression. A telephone version of the World Mental Health Composite International Diagnostic Interview explored lifetime depression, suicidal ideation, suicide attempt, and related factors among a community-dwelling sample of rural and remote Australians, selected for an interview based on a screener for psychological distress (100% of those with high distress, 75% of those with moderate distress, and 16% of those with low distress)...
May 7, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29731481/-association-between-mild-physical-injury-and-psychological-distress-shichigahama-health-promotion-project
#12
Akira Narita, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Mana Kogure, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita
Objective Although a number of previous studies have investigated the association between natural disaster-related physical injury and mental health, very few have focused on mild physical injury. The aim of this study was to evaluate the association between natural disaster-related mild physical injury and psychological distress in a cross-sectional study.Method This study is a part of the Shichigahama Health Promotion Project, which was conducted in cooperation with the Tohoku University and Shichigahama Town, Miyagi Prefecture, after the Great East Japan Earthquake (GEJE)...
2018: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/29730612/period-of-residence-in-prefabricated-temporary-housing-and-psychological-distress-after-the-great-east-japan-earthquake-a-longitudinal-study
#13
Fumiya Tanji, Yasutake Tomata, Takuya Sekiguchi, Ichiro Tsuji
OBJECTIVES: Previous studies have reported that displacement from one's own home after a natural disaster is associated with a higher degree of psychological distress. The present study investigated the longitudinal association between the period of residence in prefabricated temporary housing and psychological distress after the Great East Japan Earthquake. DESIGN, SETTING AND PARTICIPANTS: We conducted a longitudinal observation of 284 adults (aged ≥18 years) who had lived in prefabricated temporary housing in Miyagi, Northeastern Japan...
May 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29703237/optimizing-a-community-engaged-multi-level-group-intervention-to-reduce-substance-use-an-application-of-the-multiphase-optimization-strategy
#14
Liliane Cambraia Windsor, Ellen Benoit, Douglas Smith, Rogério M Pinto, Kari C Kugler
BACKGROUND: Rates of alcohol and illicit drug use (AIDU) are consistently similar across racial groups (Windsor and Negi, J Addict Dis 28:258-68, 2009; Keyes et al. Soc Sci Med 124:132-41, 2015). Yet AIDU has significantly higher consequences for residents in distressed communities with concentrations of African Americans (DCAA - i.e., localities with high rates of poverty and crime) who also have considerably less access to effective treatment of substance use disorders (SUD). This project is optimizing Community Wise, an innovative multi-level behavioral-health intervention created in partnership with service providers and residents of distressed communities with histories of SUD and incarceration, to reduce health inequalities related to AIDU...
April 27, 2018: Trials
https://www.readbyqxmd.com/read/29699557/emotional-violence-and-maternal-mental-health-a-qualitative-study-among-women-in-northern-vietnam
#15
Trần Thơ Nhị, Nguyễn Thị Thúy Hạnh, Tine M Gammeltoft
BACKGROUND: Worldwide, intimate partner violence (IPV) during pregnancy is a pressing and prevalent public health problem. Existing research has found close associations between IPV and perinatal mental health, yet little is known about women's own perceptions of these associations. This study aimed to explore Vietnamese women's experiences of emotional partner violence and their perceptions of the implications of such violence for their mental health. METHODS: The data were collected through in-depth interviews with 20 women living in Hanoi, Vietnam who had reported exposure to emotional partner violence and attained high depression scores in a prospective cohort study...
April 24, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29686756/adapting-feedback-to-individual-residents-an-examination-of-preceptor-challenges-and-approaches
#16
Amanda Roze des Ordons, Adam Cheng, Jonathan Gaudet, James Downar, Jocelyn Lockyer
Background: Feedback conversations between preceptors and residents usually occur in closed settings. Little is known about how preceptors address the challenges posed by residents with different skill sets, performance levels, and personal contexts. Objective: This study explored the challenges that preceptors experienced and approaches taken in adapting feedback conversations to individual residents. Methods: In 2015, 18 preceptors participated in feedback simulations portraying residents with variations in skill, insight, confidence, and distress, followed by debriefing of the feedback conversation with a facilitator...
April 2018: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29686492/transitioning-from-medical-school-to-residency-evaluation-of-an-innovative-immersion-rotation-for-pgy-1-paediatric-residents
#17
Stéphanie Vairy, Olivier Jamoulle, Arielle Levy, Ana Carceller
Transition from medical school to residency is stressful due to new responsibilities in patient care. Objective: To evaluate a new immersion curriculum on the transition from medical school to paediatric residency and its implications for future use in paediatric education. Methods: In July 2013, a month-rotation offering one-third of time for clinical rounds and two-thirds of time for formal courses was conducted for postgraduate year 1 residents beginning paediatric residency training...
April 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29678982/purpose-in-life-and-tobacco-use-among-community-dwelling-mothers-of-early-adolescents
#18
Yuko Morimoto, Syudo Yamasaki, Shuntaro Ando, Shinsuke Koike, Shinya Fujikawa, Sho Kanata, Kaori Endo, Miharu Nakanishi, Stephani L Hatch, Marcus Richards, Kiyoto Kasai, Mariko Hiraiwa-Hasegawa, Atsushi Nishida
OBJECTIVES: The rising prevalence of tobacco use and tobacco-attributable deaths among women is of worldwide concern. In particular, smoking prevention for mothers in early midlife is a significant international public health goal. A higher sense of purpose in life (PIL) is thought to reduce detrimental health behaviours. However, little is known about the association between a sense of PIL and tobacco use. This study investigates this association among community-dwelling mothers of early adolescents...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29672975/self-recognition-of-mental-health-problems-in-a-rural-australian-sample
#19
Tonelle E Handley, Terry J Lewin, David Perkins, Brian Kelly
OBJECTIVE: Although mental health literacy has increased in recent years, mental illness is often under-recognised. There has been little research conducted on mental illness in rural areas; however, this can be most prominent in rural areas due to factors such as greater stigma and stoicism. The aim of this study is to create a profile of those who are most and least likely to self-identify mental health problems among rural residents with moderate- to-high psychological distress. DESIGN: Secondary analysis of a longitudinal postal survey...
April 19, 2018: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29671901/using-dolls-for-therapeutic-purposes-a-study-on-nursing-home-residents-with-severe-dementia
#20
A Cantarella, E Borella, S Faggian, A Navuzzi, R De Beni
OBJECTIVES: Among the psychosocial interventions intended to reduce the behavioral and psychological symptoms of dementia (BPSD), doll therapy (DT) is increasingly used in clinical practice. Few studies on DT have been based on empirical data obtained with an adequate procedure; however, none have assessed its efficacy using an active control group, and the scales used to assess changes in BPSD are usually unreliable. The aim of the present study was to measure the impact of DT on people with severe dementia with a reliable, commonly used scale for assessing their BPSD, and the related distress in formal caregivers...
April 19, 2018: International Journal of Geriatric Psychiatry
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