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https://www.readbyqxmd.com/read/28089433/derivation-and-validation-of-a-scoring-system-for-predicting-nonalcoholic-steatohepatitis-in-taiwanese-patients-with-severe-obesity
#1
Chi-Ming Tai, Ming-Lung Yu, Hung-Pin Tu, Chih-Kun Huang, Jau-Chung Hwang, Wan-Long Chuang
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is common in severely obese Asians and may progress to advanced liver disease. Although invasive, liver biopsy is the gold standard for NASH diagnosis. Scoring systems for predicting NASH in obese Asians are scarce. OBJECTIVES: To develop and validate a scoring system to predict NASH in Taiwanese patients with severe obesity. SETTING: University hospital, Taiwan. METHODS: Preoperative clinical and laboratory data were obtained from 180 severely obese patients who underwent bariatric surgery...
December 7, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28087891/physical-activity-and-exercise-for-chronic-pain-in-adults-an-overview-of-cochrane-reviews
#2
REVIEW
Louise J Geneen, R Andrew Moore, Clare Clarke, Denis Martin, Lesley A Colvin, Blair H Smith
BACKGROUND: Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as well as more general benefits associated with improved overall physical and mental health, and physical functioning...
January 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28077164/erratum-to-novel-sorafenib-analogues-induce-apoptosis-through-shp-1-dependent-stat3-inactivation-in-human-breast-cancer-cells
#3
Chun-Yu Liu, Ling-Ming Tseng, Jung-Chen Su, Kung-Chi Chang, Pei-Yi Chu, Wei-Tien Tai, Chung-Wai Shiau, Kuen-Feng Chen
No abstract text is available yet for this article.
January 11, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28072523/snapshotting-the-excited-state-planarization-of-chemically-locked-n-n-disubstituted-dihydrodibenzo-a-c-phenazines
#4
Wei Chen, Chi-Lin Chen, Zhiyun Zhang, Yi-An Chen, Wei-Chih Chao, Jianhua Su, He Tian, Pi-Tai Chou
For deeper understanding of the coupling of electronic processes with conformational motions, we exploit a tailored strategy to harness the excited-state planarization of N,N'-disubstituted-dihydrodibenzo[a,c]phenazines by chemically halting during the structural evolution via macrocyclization process. In this new approach, 9,14-diphenyl-9,14-dihydrodibenzo[a,c]phenazine (DPAC) is used as a prototype, in which the para sites of 9,14-diphenyl are systematically enclosed by a dialkoxybenzene-alkyl-ester or -ether linkage with different chain lengths, imposing various degrees of constraint to impede the structural deformation...
January 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28063985/revealing-the-three-dimensional-architecture-of-focal-adhesion-components-to-explain-ca-2-mediated-turnover-of-focal-adhesions
#5
Shu-Jing Chang, Ying-Chi Chen, Chi-Hsun Yang, Soon-Cen Huang, Ho-Kai Huang, Chun-Chun Li, Hans I-Chen Harn, Wen-Tai Chiu
BACKGROUND: Focal adhesions (FAs) are large, dynamic protein complexes located close to the plasma membrane, which serve as the mechanical linkages and a biochemical signaling hub of cells. The coordinated and dynamic regulation of focal adhesion is required for cell migration. Degradation, or turnover, of FAs is a major event at the trailing edge of a migratory cell, and is mediated by Ca(2+)/calpain-dependent proteolysis and disassembly. Here, we investigated how Ca(2+) influx induces cascades of FA turnover in living cells...
January 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28057931/the-oprm1-a118g-polymorphism-modulates-the-descending-pain-modulatory-system-for-individual-pain-experience-in-young-women-with-primary-dysmenorrhea
#6
Shyh-Yuh Wei, Li-Fen Chen, Ming-Wei Lin, Wei-Chi Li, Intan Low, Ching-Ju Yang, Hsiang-Tai Chao, Jen-Chuen Hsieh
The mu-opioid receptor (OPRM1) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions, serves as a good clinical model of spontaneous pain. The objective of this imaging genetics study was therefore to explore if differences in functional connectivity (FC) of the DPMS between the OPRM1 A118G polymorphisms could provide a possible explanation for the differences in pain experience...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28056969/voluntary-attendance-of-small-group-brainstorming-tutoring-courses-intensify-new-clerk-s-excellence-in-clinical-care-a-pilot-study
#7
Ling-Yu Yang, Chia-Chang Huang, Hui-Chi Hsu, Ying-Ying Yang, Ching-Chi Chang, Chiao-Lin Chuang, Wei-Shin Lee, Jen-Feng Liang, Hao Min Cheng, Chin-Chou Huang, Fa-Yauh Lee, Shung-Tai Ho, Ralph Kirby
BACKGROUND: Clerkship provides a unique way of transferring the knowledge and skills gathered during medical school's curriculum into real-ward clinical care environment. The annual program evaluation has indicated that the training of clerks in diagnostic and clinical reasoning skills needed to be enhanced. Recently, "clinical excellence" program have been promoted in our institution to augment the excellence in clinical care of new clerks. Current study aims to evaluate whether this pilot program improve the "clinical excellence" of new clerks...
January 6, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28055821/prevalence-of-mindfulness-practices-in-the-us-workforce-national-health-interview-survey
#8
Diana Kachan, Henry Olano, Stacey L Tannenbaum, Debra W Annane, Ashwin Mehta, Kristopher L Arheart, Lora E Fleming, Xuan Yang, Laura A McClure, David J Lee
INTRODUCTION: Mindfulness-based practices can improve workers' health and reduce employers' costs by ameliorating the negative effect of stress on workers' health. We examined the prevalence of engagement in 4 mindfulness-based practices in the US workforce. METHODS: We used 2002, 2007, and 2012 National Health Interview Survey (NHIS) data for adults (aged ≥18 y, n = 85,004) to examine 12-month engagement in meditation, yoga, tai chi, and qigong among different groups of workers...
January 5, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28052644/effect-of-thymol-on-ca%C3%A2-%C3%A2-%C2%BA-homeostasis-and-viability-in-pc3-human-prostate-cancer-cells
#9
Jeng-Hsien Yeh, Chiang-Ting Chou, I-Shu Chen, Ti Lu, Ko-Long Lin, Chia-Cheng Yu, Wei-Zhe Liang, Hong-Tai Chang, Chun-Chi Kuo, Chin-Man Ho, Wen-Teng Chang, Pochuen Shieh, Chung-Ren Jan
Thymol is a phenolic compound that affects physiology in different cell models. However, whether thymol affects Ca²⁺ homeostasis in prostate cancer cells is unknown. The action of this compound on cytosolic Ca²⁺ concentrations ([Ca²⁺]i) and viability in PC3 human prostate cancer cells was explored. The results show that thymol at concentrations of 100-1500 μM caused [Ca²⁺]i rises in a concentration-dependent manner. Removal of extracellular Ca²⁺ reduced thymol’s effect by approximately 80%...
28, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28052066/effects-of-strontium-ranelate-on-spinal-interbody-fusion-surgery-in-an-osteoporotic-rat-model
#10
Tsung-Ting Tsai, Ching-Lung Tai, Natalie Yi-Ju Ho, Po-Liang Lai, Tsai-Sheng Fu, Chi-Chien Niu, Lih-Huei Chen, Wen-Jer Chen
Osteoporosis is a bone disease that afflicts millions of people around the world, and a variety of spinal integrity issues, such as degenerative spinal stenosis and spondylolisthesis, are frequently concomitant with osteoporosis and are sometimes treated with spinal interbody fusion surgery. Previous studies have demonstrated the efficacy of strontium ranelate (SrR) treatment of osteoporosis in improving bone strength, promoting bone remodeling, and reducing the risk of fractures, but its effects on interbody fusion surgery have not been adequately investigated...
2017: PloS One
https://www.readbyqxmd.com/read/28050045/liver-abscess-and-metastatic-endophthalmitis-secondary-to-klebsiella-pneumoniae-k1
#11
Kao-Lang Liu, Hsin-Yuan Sun, Chi-Tai Fang
No abstract text is available yet for this article.
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28038826/using-color-flow-detection-of-air-insufflation-to-improve-accuracy-in-verifying-nasogastric-tube-position
#12
Kin Wa Wong, Hok Hang Chan, Chi Pang Wong, Ming Yin Chan, Jeffrey Cheuk Wai Chau, Tai Wai Wong
OBJECTIVES: Previous studies have shown that ultrasonography (USG), as an alternative to radiography, has a good accuracy in confirming nasogastric tube (NGT) position. Color flow detection of air insufflation is a novel approach in verifying NGT position. In our study, we aimed at evaluating its sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy in confirming the NGT position, as compared with 2-dimensional (2D) USG. METHODS: The study was conducted on adult patients over a period of 38months in an emergency department in Hong Kong...
December 21, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28028848/functional-pyrimidine-based-thermally-activated-delay-fluorescence-emitters-photophysics-mechanochromism-and-fabrication-of-organic-light-emitting-diodes
#13
Paramaguru Ganesan, Revathi Ranganathan, Yun Chi, Xiao-Ke Liu, Chun-Sing Lee, Shih-Hung Liu, Gene-Hsiang Lee, Tzu-Chieh Lin, Yi-Ting Chen, Pi-Tai Chou
A new series of molecules T1-T4 possessing thermally activated delay fluorescence (TADF) have been strategically designed and synthesized. T1-T4 bear the dimethyl acridine as the electron donor, which is linked to either symmetrical or unsymmetrical diphenyl pyrimidine as an acceptor. In comparison to the ubiquitous triazine acceptor, the selection of pyrimidine as an acceptor takes its advantage of facile functionalization and less stabilized unoccupied π-orbitals so that the energy gap toward blue can be accessed...
December 28, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28027042/effectiveness-of-occupational-therapy-interventions-for-adults-with-rheumatoid-arthritis-a-systematic-review
#14
Patricia Siegel, Melissa Tencza, Beverly Apodaca, Janet L Poole
OBJECTIVE: We reviewed the efficacy of occupational therapy-related interventions for adults with rheumatoid arthritis. METHOD: We examined 51 Level I studies (19 physical activity, 32 psychoeducational) published 2000-2014 and identified from five databases. Interventions that focused solely on the upper or lower extremities were not included. RESULTS: Findings related to key outcomes (activities of daily living, ability, pain, fatigue, depression, self-efficacy, disease symptoms) are presented...
January 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28017954/-the-effect-of-exercise-and-sports-on-musculoskeletal-health-in-the-elderly
#15
Atsushi Harada
There is insufficient information on the effect of exercise and sports on musculoskeletal health in the elderly. Although the effects of sports are still unclear, the effects of exercise could be significant. For example, exercise improves osteoporosis by increasing bone mineral density and ameliorates sarcopenia by increasing muscle mass, muscular strength, and walking speed. As a result, fall risk is reduced and fracture risk is also likely to improve. Tai Chi is reportedly effective for joint pain and stiffness, and may improve symptoms of osteoarthritis...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28012797/ataxia-telangiectasia-mutated-interactor-regulates-head-and-neck-cancer-metastasis-via-kras-expression
#16
Yue-Ju Li, Wei-Ting Lai, Cheng-Chi Chang, Mark Yen-Ping Kuo, Yi-Ting Deng, Cheng-Ning Yang, Shih-Jung Cheng, Tai-Sheng Wu, Szu-Ta Chen, Been-Ren Lin
OBJECTIVES: Relapse is the most serious problem affecting the morbidity and mortality rates of patients with head and neck squamous cell carcinoma (HNSCC). Although HNSCC has been studied for several decades, the exact mechanism of cancer recurrence remains unclear. MATERIALS AND METHODS: ataxia-telangiectasia mutated interactor (ATMIN) messenger RNA(mRNA) expression was detected in HNSCC samples by quantitative RT-PCR, and was analyzed with patients' clinical outcomes by Kaplan-Meier analyses...
December 21, 2016: Oral Oncology
https://www.readbyqxmd.com/read/28004480/a-metagenomic-study-of-the-preventive-effect-of-lactobacillus-rhamnosus-gg-on-intestinal-polyp-formation-in-apc-min-mice
#17
Yueqiong Ni, Victoria Ho Yee Wong, William Chi Shing Tai, Jun Li, Wing Yan Wong, Magnolia Muk Lan Lee, Fiona Long Yan Fong, Hani El-Nezami, Gianni Panagiotou
AIMS: To investigate the in vivo effects of Lactobacillus rhamnosus GG (LGG) on intestinal polyp development and the interaction between this single-organism probiotic and the gut microbiota therein. METHODS AND RESULTS: The Apc(Min/+) mouse model was used to study the potential preventive effect of LGG on intestinal polyposis, while shotgun metagenomic sequencing was employed to characterize both taxonomic and functional changes within gut microbial community. We found that the progression of intestinal polyps in the control group altered the community functional profile remarkably despite small variation in the taxonomic diversity...
December 22, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27997913/the-impact-of-diabetes-mellitus-on-patients-undergoing-cervical-spondylotic-myelopathy-a-meta-analysis
#18
Yang Liu, De-Xiang Ban, Shi-Lian Kan, Tai-Wei Cao, Shi-Qing Feng
AIMS: We conducted a meta-analysis of eligible studies to compare the surgical outcomes between diabetic patients and non-diabetic patients who have undergone cervical spondylotic myelopathy (CSM). METHODS: A systematic literature search of PubMed, Embase, and Web of Science (up to February 10, 2016) was conducted. Eligible studies were case-control or cohort studies that compared the outcomes of cervical surgery between diabetic patients and non-diabetic patients...
December 21, 2016: European Neurology
https://www.readbyqxmd.com/read/27988242/home-based-tai-chi-chuan-may-reduce-fall-rate-compared-to-lower-extremity-exercise-training-in-older-adults-with-history-of-falls
#19
Richard Glickman-Simon
No abstract text is available yet for this article.
October 28, 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/27974236/integrative-therapy-decreases-the-risk-of-lupus-nephritis-in-patients-with-systemic-lupus-erythematosus-a-population-based-retrospective-cohort-study
#20
Ching-Mao Chang, Po-Chang Wu, Jen-Huai Chiang, Yau-Huei Wei, Fang-Pey Chen, Tzeng-Ji Chen, Tai-Long Pan, Hung-Rong Yen, Hen-Hong Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Evidence on alleviating the risk of lupus nephritis by integrative therapy with conventional medicine (CM) and herbal medicine (HM) had not been addressed. AIM OF THE STUDY: We investigated the integrative effect associated the risk by a retrospective Systemic Lupus Erythematosus (SLE) cohort from Taiwan National Health Insurance Research Database (NHIRD). MATERIALS AND METHODS: SLE patients with a catastrophic illness certificate (CIC) were retrospectively enrolled from the SLE cohort of the Taiwan NHIRD between 1997 and 2011...
January 20, 2017: Journal of Ethnopharmacology
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