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https://www.readbyqxmd.com/read/29325954/anterior-skull-base-tumor-resection-by-transciliary-supraorbital-keyhole-craniotomy-a-single-institutional-experience
#1
Ya-Jui Lin, Ko-Ting Chen, Cheng-Chi Lee, Cheng-Hong Toh, Tai-Wei Erich Wu, Yin-Cheng Huang, Peng-Wei Hsu, Yu-Jen Lu, Chi-Cheng Chuang, Pin-Yuan Chen, Kuo-Chen Wei
BACKGROUND: The prognosis and recurrence rate following resection of an anterior skull base lesion via transciliary supraorbital keyhole craniotomy depends on residual tumor volume. The extent to which pathology and size of tumor influence the resection rate using this approach is unknown. METHODS: Sixty-two patients underwent a total of 64 operations using the supraorbital keyhole approach in this retrospective study. Meningioma was the most common tumor, followed by pituitary adenoma and craniopharyngioma...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29322208/the-association-of-the-medial-joint-vacuum-phenomenon-with-ulnar-collateral-ligament-injury-in-symptomatic-elbows-of-younger-athletes
#2
Ryan Tai, Tyson Bolinske, Varand Ghazikhanian, Jacob C Mandell
OBJECTIVE: To determine the prevalence of intra-articular gas (IAG) on elbow radiography and evaluate variables, including IAG, as predictors of UCL injury. MATERIALS AND METHODS: This IRB-approved retrospective study consisted of 241 consecutive elbow radiographic studies containing AP radiographs with valgus stress of both symptomatic and asymptomatic sides in 234 patients. The IAG, medial joint space (MJS), and MJS difference between the symptomatic and asymptomatic elbow (MJSD) were evaluated by two readers, as well as patient age, gender, sport played, and handedness...
January 10, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29321480/domain-swapping-and-smyd1-interactions-with-the-pwwp-domain-of-human-hepatoma-derived-growth-factor
#3
Li-Ying Chen, Yen-Chieh Huang, Shih-Tsung Huang, Yin-Cheng Hsieh, Hong-Hsiang Guan, Nai-Chi Chen, Phimonphan Chuankhayan, Masato Yoshimura, Ming-Hong Tai, Chun-Jung Chen
The human hepatoma-derived growth factor (HDGF), containing the chromatin-associated N-terminal PWWP domain capable of binding the SMYD1 promoter, participates in various cellular processes and is involved in human cancers. We report the first crystal structures of the human HDGF PWWP domain (residues 1-100) in a complex with SMYD1 of 10 bp at 2.84 Å resolution and its apo form at 3.3 Å, respectively. The structure of the apo PWWP domain comprises mainly four β-strands and two α-helices. The PWWP domain undergoes domain swapping to dramatically transform its secondary structures, altering the overall conformation from monomeric globular folding into an extended dimeric structure upon DNA binding...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29312551/phosphorylation-of-rab37-by-protein-kinase-c-alpha-inhibits-the-exocytosis-function-and-metastasis-suppression-activity-of-rab37
#4
Hong-Tai Tzeng, Tsung-Hsin Li, Yen-An Tang, Chung-Han Tsai, Pei-Jung Frank Lu, Wu-Wei Lai, Chi-Wu Chiang, Yi-Ching Wang
We previously identified a novel Rab small GTPase protein, Rab37, which plays a critical role in regulating exocytosis of secreted glycoproteins, tissue inhibitor of metalloproteinases 1 (TIMP1) to suppress lung cancer metastasis. Patients with preserved Rab37 protein expression were associated with better prognosis. However, a significant number of the patients with preserved Rab37 expression showed poor survival. In addition, the molecular mechanism for the regulation of Rab37-mediated exocytosis remained to be further identified...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311578/promoting-induced-pluripotent-stem-cell-driven-biomineralization-and-periodontal-regeneration-in-rats-with-maxillary-molar-defects-using-injectable-bmp-6-hydrogel
#5
Ke-Hung Chien, Yuh-Lih Chang, Mong-Lien Wang, Jen-Hua Chuang, Ya-Chi Yang, Ming-Cheng Tai, Chien-Ying Wang, Yung-Yang Liu, Hsin-Yang Li, Jiang-Torng Chen, Shou-Yen Kao, Hen-Li Chen, Wen-Liang Lo
Periodontal disease may cause considerable destruction of alveolar bone, periodontal ligaments (PDLs) and cementum and even lead to progressive oral dysfunction. Periodontal tissue regeneration is the ultimate goal of periodontal disease treatment to reconstruct both structures and functions. However, the regenerative efficiency is low, possibly due to the lack of a proper periodontal microenvironment. In this study, we applied an injectable and thermosensitive chitosan/gelatin/glycerol phosphate hydrogel to provide a 3D environment for transplanted stem cells and to enhance stem cell delivery and engraftment...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311028/duodenal-invasion-of-hepatocellular-carcinoma-following-transarterial-chemoembolization
#6
I-Chang Lin, Chi-Ming Tai, Chao-Ming Tseng
No abstract text is available yet for this article.
December 30, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29310815/endoluminal-stenting-for-the-management-of-leak-following-sleeve-gastrectomy-and-loop-duodenojejunal-bypass-with-sleeve-gastrectomy
#7
Ying-Nan Tsai, Hsiu-Po Wang, Chih-Kun Huang, Po-Chin Chang, I-Chang Lin, Chi-Ming Tai
Postoperative leak is a serious complication of bariatric surgery and often results in significant morbidity and mortality. Stent placement is a less invasive alternative to surgery for the treatment of bariatric surgical leak. We evaluated the efficacy and complications of covered self-expandable metal stents (SEMS) in the treatment of post-bariatric surgical leak. We retrospectively reviewed patients who underwent stent placement for leak after bariatric surgery. Leak was diagnosed by upper gastrointestinal series or was visualized during the endoscopy...
January 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29301544/tai-chi-chuan-in-postsurgical-non-small-cell-lung-cancer-patients-study-protocol-for-a-randomized-controlled-trial
#8
Hong Pan, Yingxia Pei, Bingxue Li, Yi Wang, Jie Liu, Hongsheng Lin
BACKGROUND: Impairment of exercise capacity remains a common adverse effect of non-small cell lung cancer (NSCLC) survivors after surgery. Previous research has suggested that Tai Chi Chuan (TCC) offers an exercise capacity benefit in several types of cancers. This is a randomized trial to investigate the efficacy and safety of TCC in postoperative NSCLC patients over an observation period of 3 months and a 9-month follow-up. METHODS/DESIGN: Using a prospective, one center and randomized design, 120 subjects with histologically confirmed stage I-IIIA NSCLC following complete surgical resection will potentially be eligible for this trial...
January 4, 2018: Trials
https://www.readbyqxmd.com/read/29300980/distinct-relapse-rates-and-risk-predictors-after-discontinuing-tenofovir-and-entecavir-therapy
#9
Tung-Hung Su, Hung-Chih Yang, Tai-Chung Tseng, Jyh-Ming Liou, Chen-Hua Liu, Chi-Ling Chen, Pei-Jer Chen, Ding-Shinn Chen, Chun-Jen Liu, Jia-Horng Kao
Background: We investigated the patterns; predictors for virological relapse (VR), clinical relapse (CR), sustained clinical response (SCR); and retreatment outcomes after nucleos(t)ide analogue (NUC) therapy discontinuation. Methods: Chronic hepatitis B patients discontinuing NUC were prospectively enrolled. Viral and host predictors, including HBsAg, anti-HBc, the single nucleotide polymorphisms of NTCP (rs2296651), CTLA4 (rs231775), rs3077 (HLA-DPA1), and rs9277535 (HLA-DPB1), and post-therapy predictors were investigated...
January 2, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29288507/effectiveness-of-executive-function-training-on-mental-set-shifting-working-memory-and-inhibition-in-healthy-older-adults-a-double-blind-randomized-controlled-trial
#10
Huei-Ling Chiu, Pi-Tuan Chan, Ching-Chiu Kao, Hsin Chu, Pi-Chen Chang, Shu-Tai Sheen Hsiao, Doresses Liu, Wen-Chi Chang, Kuei-Ru Chou
AIMS: To evaluate the effectiveness of executive function training on mental set shifting, working memory and inhibition for healthy older adults. BACKGROUND: Executive functions control and guide individuals' behaviors through a top-down cognitive model and have been regarded as the exhibition and integration of various high-level cognitive functions. However, prior studies have rarely focused on the subcomponent indicators of executive function, such as mental set shifting, working memory and inhibition in healthy older adults...
December 29, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29284025/clinical-management-and-risk-reduction-in-women-with-low-grade-squamous-intraepithelial-lesion-cytology-a-population-based-cohort-study
#11
Yi-Jou Tai, Yun-Yuan Chen, Huang-Cheng Hsu, Chun-Ju Chiang, San-Lin You, Hui-Chi Chen, Chi-An Chen, Wen-Fang Cheng
We analyzed the management and risk of subsequent cervical intraepithelial neoplasm 3 (CIN3) and invasive cervical cancer in women with low-grade squamous intraepithelial lesion (LSIL) cytology. A total of 53,293 women with a new diagnosis of cytologic LSIL were identified in Taiwan's national cervical screening registration database. Based on the retrieved clinical management data, the incidence of subsequent CIN3+ lesions was determined, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model...
2017: PloS One
https://www.readbyqxmd.com/read/29283424/integrated-microrna-mrna-analysis-reveals-mir-204-inhibits-cell-proliferation-in-gastric-cancer-by-targeting-cks1b-cxcl1-and-gprc5a
#12
Sirjana Shrestha, Chi-Dung Yang, Hsiao-Chin Hong, Chih-Hung Chou, Chun-San Tai, Men-Yee Chiew, Wen-Liang Chen, Shun-Long Weng, Chung-Chu Chen, Yi-An Chang, Meng-Lin Lee, Wei-Yun Huang, Sheng-Da Hsu, Yi-Chang Chen, Hsien-Da Huang
Gastric cancer (GC) is the second most frequent cause of cancer-related deaths worldwide. MicroRNAs are single-stranded RNA molecules of 21-23 nucleotides that regulate target gene expression through specific base-pairing interactions between miRNA and untranslated regions of targeted mRNAs. In this study, we generated a multistep approach for the integrated analysis of miRNA and mRNA expression. First, both miRNA and mRNA expression profiling datasets in gastric cancer from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) identified 79 and 1042 differentially expressed miRNAs and mRNAs, respectively, in gastric cancer...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29279375/field-and-clinically-derived-estimates-of-wolbachia-mediated-blocking-of-dengue-virus-transmission-potential-in-aedes-aegypti-mosquitoes
#13
Lauren B Carrington, Bich Chau Nguyen Tran, Nhat Thanh Hoang Le, Tai Thi Hue Luong, Truong Thanh Nguyen, Phong Thanh Nguyen, Chau Van Vinh Nguyen, Huong Thi Cam Nguyen, Trung Tuan Vu, Long Thi Vo, Dui Thi Le, Nhu Tuyet Vu, Giang Thi Nguyen, Hung Quoc Luu, Anh Duc Dang, Timothy P Hurst, Scott L O'Neill, Vi Thuy Tran, Duong Thi Hue Kien, Nguyet Minh Nguyen, Marcel Wolbers, Bridget Wills, Cameron P Simmons
The wMel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that wMel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The wMel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29258504/dipeptidyl-peptidase-4-inhibitor-decreases-the-risk-of-atrial-fibrillation-in-patients-with-type-2-diabetes-a-nationwide-cohort-study-in-taiwan
#14
Chia-Yu Chang, Yung-Hsin Yeh, Yi-Hsin Chan, Jia-Rou Liu, Shang-Hung Chang, Hsin-Fu Lee, Lung-Sheng Wu, Kun-Chi Yen, Chi-Tai Kuo, Lai-Chu See
BACKGROUND: Whether dipeptidyl peptidase-4 inhibitor (DPP4i) is associated with a lower risk of new-onset atrial fibrillation (AF) in patients with diabetes remains unclear. This study aimed to evaluate the risk of AF associated with use of DPP4i among a longitudinal cohort of patients with diabetes. METHODS: Over a 3-year period, 480,000 patients with diabetes were analyzed utilizing Taiwan's National Health Insurance Research Database and 90,880 patients taking metformin as first-line therapy were enrolled...
December 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29251659/exercise-in-the-management-of-knee-and-hip-osteoarthritis
#15
Elizabeth Wellsandt, Yvonne Golightly
PURPOSE OF REVIEW: This review focuses on studies published during July 2001 to August 2017 of exercise as an intervention in knee and hip osteoarthritis, including its influence on an array of patient outcomes. RECENT FINDINGS: Studies continue to illustrate the efficacy of exercise in treating and managing osteoarthritis, with current literature more focused on the knee compared with the hip joint. Both traditional (e.g. strength, aerobic, flexibility) and more nontraditional (e...
December 14, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29249417/quantification-of-serum-hepatitis-b-core-antibody-to-predict-off-entecavir-relapse-in-patients-with-chronic-hepatitis-b
#16
Cheng-Hao Tseng, Yao-Chun Hsu, Chi-Yang Chang, Tai-Chung Tseng, Ming-Shiang Wu, Jaw-Town Lin, Jia-Horng Kao
BACKGROUND/PURPOSE: The predictors of off-therapy response in patients treated with neucleos(t)ide analogue (NA) have not been elucidated. It remained unexplored whether serum level of hepatitis B core antibody (anti-HBc) at the end of NA therapy was associated with relapse risks. METHODS: This prospective study monitored 82 chronic hepatitis B (CHB) patients after discontinuing entecavir. All patients had been treated for 3 years or longer and serologically negative for viral DNA and HBeAg at treatment cessation...
December 14, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29247549/a-training-program-of-a-new-simplified-classification-of-magnified-narrow-band-imaging-for-superficial-esophageal-squamous-cell-carcinoma
#17
Wen-Lun Wang, Sherry Yueh-Hsia Chiu, Ching-Tai Lee, Cheng-Hao Tseng, Chien-Chuan Chen, Ming-Lun Han, Chen-Shuan Chung, Ping-Hsin Hsieh, Wei-Lun Chang, Ping-Hsiu Wu, Wen-Hung Hsu, Hsu-Heng Yen, Hsiu-Po Wang, Chi-Yang Chang
BACKGROUND: Optimal staging of the invasion depth of superficial esophageal squamous cell carcinoma (SESCC) is vital prior to endoscopic treatment. A new simplified magnified narrow-band imaging (M-NBI) classification system based on vascular architecture has recently been developed by the Japan Esophageal Society, however its validity remains uncertain. METHODS: A total of 11 experienced and 11 inexperienced endoscopists were invited to join an endoscopic training program, which was composed of pre-test, educational section, and post-test...
December 16, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29231720/phosphorylation-of-isoflavone-by-bacillus-subtilis-bcrc-80517-may-represent-xenobiotic-metabolism
#18
Chen Hsu, Bo-Yuan Wu, Yu-Chuan Chang, Chi-Fon Chang, Tai-Ying Chiou, Nan-Wei Su
Soy isoflavones, daidzein (DAI) and genistein (GEN), have beneficial effects on human health. However, their oral bioavailability is hampered by low aqueous solubility. Our previous study revealed two water-soluble phosphorylated isoflavones conjugates of isoflavones, daidzein 7-O-phosphate and genistein 7-O-phosphate, generated by biotransformation of Bacillus subtilis BCRC80517 cultivated with isoflavones. In this study, two novel derivatives of isoflavones, daidzein 4'-O-phosphate and genistein 4'-O-phosphate, were identified by HPLC-ESI-MS/MS and 1H, 13C and 31P NMR and the biotransformation road map was proposed...
December 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29228736/bleeding-risk-with-dabigatran-rivaroxaban-warfarin-and-antiplatelet-agent-in-asians-with-non-valvular-atrial-fibrillation
#19
Yi-Hsin Chan, Yung-Hsin Yeh, Hui-Tzu Tu, Chi-Tai Kuo, Shang-Hung Chang, Lung-Sheng Wu, Hsin-Fu Lee, Lai-Chu See
It is not understood if dabigatran or rivaroxaban are superior to antiplatelet agents (AA) for safety outcomes in Asians with non-valvular atrial fibrillation (NVAF). In this study we evaluated the bleeding risk of dabigatran, rivaroxaban, warfarin and AA in Asians with NVAF. This national retrospective cohort study analyzed 6,600, 3,167, 5,338 and 8,238 consecutive NVAF patients taking dabigatran, rivaroxaban, warfarin or AAs (including aspirin, clopidogrel or ticlopidine), respectively, from June 1, 2012 to December 31, 2013...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29222705/tai-chi-and-qigong-for-cancer-related-symptoms-and-quality-of-life-a-systematic-review-and-meta-analysis
#20
REVIEW
Peter M Wayne, M S Lee, J Novakowski, K Osypiuk, J Ligibel, L E Carlson, R Song
PURPOSE: This study aims to summarize and critically evaluate the effects of Tai Chi and Qigong (TCQ) mind-body exercises on symptoms and quality of life (QOL) in cancer survivors. METHODS: A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluating TCQ for fatigue, sleep difficulty, depression, pain, and QOL in cancer patients, published through August 2016. Meta-analysis was used to estimate effect sizes (ES, Hedges' g) and publication bias for randomized controlled trials (RCTs)...
December 8, 2017: Journal of Cancer Survivorship: Research and Practice
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