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https://www.readbyqxmd.com/read/29650856/-a-case-of-performed-right-colectomy-with-pancreato-duodenectomy-for-transverse-colon-cancer-invased-to-duodenum
#1
Ryutaro Udo, Masanobu Enomoto, Kazushige Tsurui, Yuu Kuboyama, Hiroshi Kuwabara, Masatoshi Shigoka, Tetsuo Ishizaki, Kenji Katsumata, Hiyo Obikane, Akihiko Tsuchida
There is a clear consensus regarding the combined resection of organs with cancer invasion, patients with colon cancer. However, there are very few reports to our knowledge regarding the use of pancreato-duodenectomy(PD)for colon cancer patients with cancer invasion in the duodenum. We here report a colon cancer patient in whom we performed PD and right hemicolectomy, who showed favorable results with no recurrence. The patient was a 69-year-old woman. Her chief complaint was hypogastric pain. Her previous doctor performed colonoscopy and a colonoscopic biopsy, and detected a type 2 lesion, throughout the entire circumference of the transverse colon near the liver, and she was diagnosed with adenocarcinoma...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650837/-laparoscopic-distal-gastrectomy-for-elderly-patients-with-advanced-gastric-cancer-and-gastric-outlet-obstruction-a-case-report
#2
Kurumi Tsuchihashi, Ken Yuu, Satoshi Okumura, Sho Toyoda, Hiroshi Yasuda, Kansuke Yamamoto, Aya Ito, Naoto Mizumura, Hiroshi Tsuchihashi, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama
A 90-year-old female patient was admitted to our hospital with a chief complaint of vomiting.Gastroscopy revealed type 3 gastric cancer and gastric outlet obstruction(GOO).Abdominal computed tomography revealed thickening of the antral wall and suggested the presence of 3 perigastric lymph node metastases, but there was no ascitic fluid or distant metastasis.The clinical diagnosis was T4a(SE)N2H0CYXP0M0, Stage III B, according to the Japanese Classification of Gastric Carcinoma.Her general conditions including kidney and cardiac function were good, we considered that she was able to tolerate radical distal gastrectomy...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29618688/-human-herpesvirus-6-pneumonitis-following-autologous-peripheral-blood-stem-cell-transplantation
#3
Yuu Saitoh, Moritaka Gotoh, Seiichiro Yoshizawa, Daigo Akahane, Hiroaki Fujimoto, Yoshikazu Ito, Kazuma Ohyashiki
A-46-year-old man was diagnosed with peripheral T cell lymphoma, not otherwise specified. He achieved a complete remission after pirarubicin, cyclophosphamide, vincristine, and prednisolone (THP-COP) therapy and successful autologous peripheral blood stem-cell transplantation (AutoSCT). However, 6 months post AutoSCT, he complained of fever. Chest computed tomography of the patient displayed bilateral interstitial pneumonitis. Human herpesvirus-6 (HHV-6) DNA was detected in his bronchoalveolar lavage fluid...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29618282/neuroprotective-effect-of-citrus-kawachiensis-kawachi-bankan-peels-a-rich-source-of-naringin-against-global-cerebral-ischemia-reperfusion-injury-in-mice
#4
Satoshi Okuyama, Kana Yamamoto, Hirotomo Mori, Atsushi Sawamoto, Yoshiaki Amakura, Morio Yoshimura, Arisa Tamanaha, Yuu Ohkubo, Kuniaki Sugawara, Masahiko Sudo, Mitsunari Nakajima, Yoshiko Furukawa
Cerebral ischemia/reperfusion is known to induce the generation of reactive oxygen species and inflammatory responses. Numerous studies have demonstrated that naringin (NGIN) has anti-oxidant and anti-inflammatory properties. We previously reported that Citrus kawachiensis contains a large quantity of NGIN in its peel. In the present study, we orally (p.o.) administered dried peel powder of C. kawachiensis to mice of a transient global ischemia model and found in the hippocampus region that it 1) suppressed neuronal cell death, 2) reversed the reduction in the level of phosphorylated calcium-calmodulin-dependent protein kinase II, 3) had the tendency to reverse the reduction in the level of glutathione, and 4) blocked excessive activation of microglia and astrocytes...
April 4, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29589109/prevalence-and-associated-factors-of-preoperative-functional-disability-in-elective-surgical-patients-over-55-years-old-a-prospective-cohort-study
#5
Mitsuru Ida, Yusuke Naito, Yasunori Matsunari, Yuu Tanaka, Satoki Inoue, Masahiko Kawaguchi
PURPOSE: In preoperative settings, patients may have functional disabilities due to the disease for which surgery is being performed or comorbidities, but the associated and predictive factors remain unknown. This study examined the prevalence of preoperative functional disability and clarified the associated factors. METHODS: Individuals aged ≥ 55 years who were scheduled to undergo surgery in a tertiary-care hospital in Japan between April 2016 and September 2016 were eligible for enrolment in the study...
March 27, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29557709/disposition-and-metabolism-of-the-g-protein-coupled-receptor-40-agonist-tak-875-fasiglifam-in-rats-dogs-and-humans
#6
Akifumi Kogame, Ronald Lee, Liping Pan, Miyako Sudo, Masami Nonaka, Yuu Moriya, Tomoaki Higuchi, Yoshihiko Tagawa
1. The absorption, distribution, metabolism and excretion of fasiglifam were investigated in rats, dogs, and humans. 2. The absolute oral bioavailability of fasiglifam was high in all species (> 76.0%). 3. After oral administration of [14 C]fasiglifam, the administered radioactivity was quantitatively recovered and the major route of excretion of radioactivity was via feces in all species. 4. Fasiglifam was a major component in the plasma and feces in all species. Its oxidative metabolite (M-I) was observed as a minor metabolite in rat and human plasma (< 10% of plasma radioactivity)...
March 20, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29548825/dok-3-and-dok-1-2-adaptors-play-distinctive-roles-in-cell-fusion-and-proliferation-during-osteoclastogenesis-and-cooperatively-protect-mice-from-osteopenia
#7
Shuhei Kajikawa, Yuu Taguchi, Tadayoshi Hayata, Yoichi Ezura, Ryo Ueta, Sumimasa Arimura, Jun-Ichiro Inoue, Masaki Noda, Yuji Yamanashi
Bone mass is determined by coordinated acts of osteoblasts and osteoclasts, which control bone formation and resorption, respectively. Osteoclasts are multinucleated, macrophage/monocyte lineage cells from bone marrow. The Dok-family adaptors Dok-1, Dok-2 and Dok-3 are expressed in the macrophage/monocyte lineage and negatively regulate many signaling pathways, implying roles in osteoclastogenesis. Indeed, mice lacking Dok-1 and Dok-2, the closest homologues with redundant functions, develop osteopenia with increased osteoclast counts compared to the wild-type controls...
March 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29526925/involvement-of-the-response-regulator-ctra-in-the-extracellular-dna-production-of-the-marine-bacterium-rhodovulum-sulfidophilum
#8
Hiroyuki Komatsu, Junya Yamamoto, Hiromichi Suzuki, Nobuyoshi Nagao, Yuu Hirose, Takashi Ohyama, So Umekage, Yo Kikuchi
The marine bacterium Rhodovulum sulfidophilum is a nonsulfur phototrophic bacterium, which is known to produce extracellular nucleic acids in soluble form in culture medium. In the present paper, constructing the response regulator ctrA-deficient mutant of R. sulfidophilum, we found that this mutation causes a significant decrease in the extracellular DNA production. However, by the introduction of a plasmid containing the wild type ctrA gene into the mutant, the amount of extracellular DNA produced was recovered...
March 12, 2018: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/29459692/isolation-of-uracil-auxotroph-mutants-of-coral-symbiont-alga-for-symbiosis-studies
#9
Yuu Ishii, Shinichiro Maruyama, Konomi Fujimura-Kamada, Natsumaro Kutsuna, Shunichi Takahashi, Masakado Kawata, Jun Minagawa
Coral reef ecosystems rely on stable symbiotic relationship between the dinoflagellate Symbiodinium spp. and host cnidarian animals. The collapse of such symbiosis could cause coral 'bleaching' and subsequent host death. Despite huge interest on Symbiodinium, lack of mutant strains and readily available genetic tools have hampered molecular research. A major issue was the tolerance to marker antibiotics. Here, we isolated Symbiodinium mutants requiring uracil for growth, and hence, useful in transformation screening...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459145/discovery-of-1-2-3-4-tetrahydropyrimido-1-2-a-benzimidazoles-as-novel-class-of-corticotropin-releasing-factor-1-receptor-antagonists
#10
Takuto Kojima, Michiyo Mochizuki, Takafumi Takai, Yasutaka Hoashi, Sachie Morimoto, Masaki Seto, Minoru Nakamura, Katsumi Kobayashi, Yuu Sako, Maiko Tanaka, Naoyuki Kanzaki, Yohei Kosugi, Takahiko Yano, Kazuyoshi Aso
A new class of corticotropin releasing factor 1 (CRF1 ) receptor antagonists characterized by a tricyclic core ring was designed and synthesized. Novel tricyclic derivatives 2a-e were designed as CRF1 receptor antagonists based on conformation analysis of our original 2-anilinobenzimidazole CRF1 receptor antagonist. The synthesized tricyclic derivatives 2a-e showed CRF1 receptor binding activity with IC50 values of less than 400 nM, and the 1,2,3,4-tetrahydropyrimido-[1,2-a]benzimidazole derivative 2e was selected as a lead compound with potent in vitro CRF1 receptor binding activity (IC50 = 7...
February 8, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29449379/draft-genome-sequence-of-the-nitrogen-fixing-and-hormogonia-inducing-cyanobacterium-nostoc-cycadae-strain-wk-1-isolated-from-the-coralloid-roots-of-cycas-revoluta
#11
Yu Kanesaki, Masaki Hirose, Yuu Hirose, Takatomo Fujisawa, Yasukazu Nakamura, Satoru Watanabe, Shigeru Matsunaga, Hiroko Uchida, Akio Murakami
We report here the whole-genome sequence of Nostoc cycadae strain WK-1, which was isolated from cyanobacterial colonies growing in the coralloid roots of the gymnosperm Cycas revoluta It can provide valuable resources to study the mutualistic relationships and the syntrophic metabolisms between the cyanobacterial symbiont and the host plant, C. revoluta .
February 15, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29427085/regulatory-effects-of-neuroinflammatory-responses-through-brain-derived-neurotrophic-factor-signaling-in-microglial-cells
#12
Sheng-Wei Lai, Jia-Hong Chen, Hsiao-Yun Lin, Yu-Shu Liu, Cheng-Fang Tsai, Pei-Chun Chang, Dah-Yuu Lu, Chingju Lin
Inhibition of microglial over-activation is an important strategy to counter balance neurodegenerative progression. We previously demonstrated that the adenosine monophosphate-activated protein kinase (AMPK) may be a therapeutic target in mediating anti-neuroinflammatory responses in microglia. Brain-derived neurotrophic factor (BDNF) is one of the major neurotrophic factors produced by astrocytes to maintain the development and survival of neurons in the brain, and have recently been shown to modulate homeostasis of neuroinflammation...
February 9, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29424280/the-peel-of-citrus-kawachiensis-kawachi-bankan-ameliorates-microglial-activation-tau-hyper-phosphorylation-and-suppression-of-neurogenesis-in-the-hippocampus-of-senescence-accelerated-mice
#13
Satoshi Okuyama, Yoshimi Kotani, Kana Yamamoto, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Yuu Ohkubo, Arisa Tamanaha, Mitsunari Nakajima, Yoshiko Furukawa
We previously reported that the dried peel powder of Citrus kawachiensis, one of the citrus products of Ehime, Japan, exerted anti-inflammatory effects in the brain of a lipopolysaccharide-injected systemic inflammation animal model. Inflammation is one of the main mechanisms underlying aging in the brain; therefore, we herein evaluated the anti-inflammatory and other effects of the dried peel powder of C. kawachiensis in the senescence-accelerated mouse-prone 8 (SAMP8) model. The C. kawachiensis treatment inhibited microglial activation in the hippocampus, the hyper-phosphorylation of tau at 231 of threonine in hippocampal neurons, and ameliorated the suppression of neurogenesis in the dentate gyrus of the hippocampus...
February 9, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29394662/-esophagogastric-junction-cancer-resection-with-bilateral-adrenal-metastasis-a-case-report
#14
Sho Toyoda, Atsuo Imagawa, Kouichi Demura, Kurumi Tsuchihashi, Satoshi Okumura, Hiroshi Yasuda, Kansuke Yamamoto, Aya Ito, Naoto Mizumura, Ken Yuu, Hiroshi Tsuchihashi, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama
The patient was a 64-year-old man with esophagogastric junction cancer. We performed right thoracotomy-laparotomy for lower esophageal and cardiac gastric resection, D2 lymphadenectomy, and reconstruction of a gastric tube in October 2011. Histopathology confirmed T4aN1M1(LYM), Stage IV cancer(Japanese Classification of Gastric Carcinoma, 14th edition) with R0 resection. Because of preexisting alcoholic cirrhosis, postoperative chemotherapy was not an option. In March 2014, we performed left adrenalectomy for left adrenal metastasis, and in December 2014, we performed right adrenalectomy for metastasis to the right adrenal gland...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394627/-a-case-of-rectal-cancer-presenting-with-schistosomiasis-japonica-eggs
#15
Satoshi Okumura, Atsuo Imagawa, Hiroshi Kawashima, Sho Toyoda, Hiroshi Yasuda, Kansuke Yamamoto, Aya Ito, Naoto Mizumura, Ken Yuu, Hiromitsu Maehira, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama
A 87-year-old man had used to live in Shizuoka Prefecture. He got colonoscopy due to melena, and a type 1 tumor about 3 cm was detected in the rectum. He was diagnosed with rectal cancer. We performed a laparoscopic low anterior resection with lymphadenectomy. Histopathological findings shows tub1, pSM(7mm), med, INF a, ly1, v0, pPM0, pDM0, pN0(0/7), T1bN0M0, Stage I . Schistosoma japonica eggs were seen in submucosal of the rectum not around the tumor but also normal tissue. The eggs embolized microvessels...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29387517/effect-of-lactobacillus-casei-strain-shirota-fermented-milk-on-metabolic-abnormalities-in-obese-prediabetic-japanese-men-a-randomised-double-blind-placebo-controlled-trial
#16
Eiichiro Naito, Yasuto Yoshida, Satoru Kunihiro, Kumiko Makino, Kohei Kasahara, Yuu Kounoshi, Masanori Aida, Ryotaro Hoshi, Osamu Watanabe, Tomoki Igarashi, Kouji Miyazaki, Hideki Ito
An obesity-related prediabetic state is characterised by metabolic abnormalities such as post-glucose load hyperglycaemia and dyslipidaemia and consequently increases the risk for type 2 diabetes and cardiovascular disease. This study aimed to investigate the effects of Lactobacillus casei strain Shirota (LcS) on metabolic abnormalities in obese prediabetic subjects in a randomised, double-blind, placebo-controlled trial. Herein, 100 obese subjects (body mass index ≥25), who had moderate post-load hyperglycaemia (1-hr post-load plasma glucose (PG) levels ≥180 mg/dl during the oral glucose tolerance test), consumed LcS-fermented milk or placebo milk daily for 8 weeks...
2018: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/29318565/a-case-of-severe-stenosis-of-hepatic-veins-and-inferior-vena-cava-with-stomal-variceal-bleeding-induced-by-oxaliplatin-based-chemotherapy
#17
Hayato Yamaguchi, Yoshihiro Furuichi, Yoshitaka Kasai, Hirohito Takeuchi, Yuu Yoshimasu, Katsutoshi Sugimoto, Ikuo Nakamura, Takao Itoi
A 27-year-old woman with colon cancer and liver metastasis was referred to our hospital. Colectomy and colostomy were performed to improve her ileus. Following 13 sessions of oxaliplatin-based chemotherapy (OC) with mFOLFOX6 + bevacizumab, thrombocytopenia and frequent peristomal bleeding occurred. Computed tomography showed severe ascites, splenomegaly, significant collateral veins around the stoma, and severe stenosis of the hepatic veins (HV) and inferior vena cava (IVC). Ultrasound elastography showed high liver (and spleen) stiffness values...
April 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29301329/differential-characterization-of-temozolomide-resistant-human-glioma-cells
#18
Sheng-Wei Lai, Bor-Ren Huang, Yu-Shu Liu, Hsiao-Yun Lin, Chun-Chuan Chen, Cheng-Fang Tsai, Dah-Yuu Lu, Chingju Lin
Glioblastoma multiforme (GBM) is the most common type of primary and malignant tumor occurring in the adult central nervous system. Temozolomide (TMZ) has been considered to be one of the most effective chemotherapeutic agents to prolong the survival of patients with glioblastoma. Many glioma cells develop drug-resistance against TMZ that is mediated by increasing O -6-methylguanine-DNA methyltransferase (MGMT) levels. The expression of connexin 43 was increased in the resistant U251 subline compared with the parental U251 cells...
January 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29283918/clinical-utility-of-intraoperative-motor-evoked-potential-monitoring-to-prevent-postoperative-spinal-cord-injury-in-thoracic-and-thoracoabdominal-aneurysm-repair-an-audit-of-the-japanese-association-of-spinal-cord-protection-in-aortic-surgery-database
#19
Kenji Yoshitani, Kenichi Masui, Masahiko Kawaguchi, Mikito Kawamata, Manabu Kakinohana, Shinya Kato, Kyoko Hasuwa, Michiaki Yamakage, Yusuke Yoshikawa, Kimitoshi Nishiwaki, Tadashi Aoyama, Yoshimi Inagaki, Kazumasa Yamasaki, Mishiya Matsumoto, Kazuyoshi Ishida, Atsuo Yamashita, Katsuhiro Seo, Shinichi Kakumoto, Hironobu Hayashi, Yuu Tanaka, Satoshi Tanaka, Takashi Ishida, Hiroyuki Uchino, Takayasu Kakinuma, Yoshitsugu Yamada, Yoshiteru Mori, Shunsuke Izumi, Kunihiro Nishimura, Michikazu Nakai, Yoshihiko Ohnishi
BACKGROUND: Spinal cord ischemic injury is the most devastating sequela of descending and thoracoabdominal aortic surgery. Motor-evoked potentials (MEPs) have been used to intraoperatively assess motor tract function, but it remains unclear whether MEP monitoring can decrease the incidence of postoperative motor deficits. Therefore, we reviewed multicenter medical records of patients who had undergone descending and thoracoabdominal aortic repair (both open surgery and endovascular repair) to assess the association of MEP monitoring with postoperative motor deficits...
March 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29278294/chemotherapy-immunophenoprofiles-in-non-small-cell-lung-cancer-by-personalized-membrane-proteomics
#20
Denise Utami Putri, Po-Hao Feng, Yuu-Hueih Hsu, Kang-Yun Lee, Feng-Wen Jiang, Lu-Wei Kuo, Yu-Ju Chen, Chia-Li Han
OBJECTIVES: No study has addressed how the immune status at the molecular level is affected by first-line pemetrexed and cisplatin (PEM-CIS) combination therapy in patients with non-small-cell lung cancer (NSCLC). Thus, we aimed to identify the immune status from membrane proteome alterations in patients with NSCLC upon PEM-CIS treatment. METHODS: The paired peripheral blood mononuclear cells (PBMCs) were collected from four patients with lung adenocarcinoma before and after the first regimen of PEM-CIS treatment and applied quantitative membrane proteomics analysis...
March 2018: Proteomics. Clinical Applications
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