Read by QxMD icon Read


Hajime Suzuki, Takahiro Sakabe, Yuu Hirose, Toshihiko Eki
We aimed to develop the bioassays for genotixicity and/or oxidative damage using the recombinant yeast. A genotoxicity assay was developed using recombinant Saccharomyces cerevisiae strain BY4741 with a green fluorescent protein (GFP) reporter plasmid, driven by the DNA damage-responsive RNR3 promoter. Enhanced fluorescence induction was observed in DNA repair-deficient strains treated with methyl methanesulfonate, but not with hydrogen peroxide. A GFP reporter yeast strain driven by the oxidative stress-responsive TRX2 promoter was newly developed to assess oxidative damage, but fluorescence was poorly induced by oxidants...
October 21, 2016: Applied Microbiology and Biotechnology
Jun Atsuta, Satoki Inoue, Yuu Tanaka, Keiko Abe, Hiroyuki Nakase, Masahiko Kawaguchi
PURPOSE: Postoperative nausea and vomiting (PONV) is a common complication after craniotomy. Vomiting may be a potentially hazardous complication in neurosurgical patients. We compared the efficacy of fosaprepitant and droperidol for the prevention of PONV, vomiting in particular, after craniotomy. METHODS: Patients scheduled to undergo elective craniotomy were enrolled in the study and randomly divided in a double-blind manner into two groups to receive either 150 mg of fosaprepitant (group F) or 1...
October 18, 2016: Journal of Anesthesia
Yuu Sasaki, Yuka Horikawa, Takashi Tokushima, Kazumasa Okada, Masaki Oura, Misako Aida
The hydration structure of trimethylamine N-oxide (TMAO) in aqueous solutions has been investigated by means of soft X-ray spectroscopy and chemometric analysis. Soft X-ray absorption spectra in the O 1s region have a concentration-dependent shoulder at 533 eV, which is assigned to the 6a1 resonance of TMAO. Soft X-ray emission spectra acquired at this resonance comprise both TMAO and water components, with a prominent peak at 525.6 eV which is assigned to the emission caused by the 5e to O 1s transition. An apparent inverse concentration dependence of around 523 eV suggests that the electronic structure of water is modified by the strong interaction with TMAO...
October 5, 2016: Physical Chemistry Chemical Physics: PCCP
Hiromichi Katayama, Hiroshi Aoki, Katsuyuki Taguchi, Yuu Sakurada, Tomonori Sato, Masahiro Takahashi, Rie Shibuya, Hiroshi Naganuma, Shigeto Ishidoya
We report a histologically pure stage 1 seminoma with an elevated human chorionic gonadotropin (hCG). A 38 year-old man was referred for the evaluation of the left testicular swelling. He showed an elevated serum hCG level of 25,265 mIU/ml with normal a fetoprotein and lactate dehydrogenase. Imaging showed heterogeneous tumor without any metastatic lesions. We conducted 4 courses of chemotherapy before detecting hCG nadir. The final pathological report showed pure seminoma with syncytiotrophoblastic cells but no choriocarcinoma components...
November 2016: Urology Case Reports
Ken Yuu, Hiroshi Kawashima, Sho Toyoda, Satoshi Okumura, Kansuke Yamamoto, Naoto Mizumura, Aya Ito, Hiromitsu Maehira, Atsuo Imagawa, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama
An 80-year-old man who had undergone distal gastrectomy and Billroth-II gastrojejunostomy 38 years previously, for a benign gastric ulcer, was diagnosed with remnant gastric cancer based on upper gastrointestinal endoscopy findings. He presented at our emergency department with acute-onset epigastric pain due to perforated remnant gastric cancer. Conservative medical management was selected, including nasogastric tube insertion, antibiotics, and proton pump inhibitors, because his peritonitis was limited to his epigastrium and his general condition was stable...
2016: Case Reports in Surgery
Kunihito Suzuki, Kazuhito Yajima, Yoshiaki Iwasaki, Ken Yuu, Ryouki Oohinata, Misato Amaki
AIM: The aim of this study was to clarify the clinical outcomes of staging laparoscopy(SL)for patients with positive peritonealwashing cytology(CY1P0)after S-1 administration. PATIENTS AND METHODS: Since 2007, eight CY1P0 patients who underwent SL after S-1 administration were enrolled. S-1 was administered according to the ACTS-GC and SL was performed after 8 courses of S-1 treatment. RESULTS: SL was ended with adequate observation of intra-abdominalcavity in allthe patients with a median time of 68 minutes(range: 52-76 minutes)...
September 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Yuu Tanaka, Masahiko Kawaguchi, Yoshinori Noguchi, Kenji Yoshitani, Mikito Kawamata, Kenichi Masui, Takeo Nakayama, Yoshitugu Yamada
Motor evoked potential (MEP) monitoring has been used to prevent neurological complications such as paraplegia in patients who underwent thoracic or thoracoabdominal aortic aneurysm (TAA/TAAA) surgery. The object of this study was making a systematic review to survey the performance of MEP monitoring during TAA/TAAA open repair surgery. We searched electronic databases for relevant studies. We summarized the diagnostic data with summary sensitivity, summary specificity and forest plots of pooled sensitivity, and conducted sub-group analysis...
September 9, 2016: Journal of Anesthesia
Michiyo Mochizuki, Masakuni Kori, Mitsunori Kono, Takahiko Yano, Yuu Sako, Maiko Tanaka, Naoyuki Kanzaki, Albert C Gyorkos, Christopher P Corrette, Kazuyoshi Aso
A promising lead compound 1 of a benzimidazole series has been identified as a corticotropin-releasing factor 1 (CRF1) receptor antagonist. In this study, we focused on replacement of a 7-alkylamino group of 1, predicted to occupy a large lipophilic pocket of a CRF1 receptor, with an aryl group. During the course of this examination, we established new synthetic approaches to 2,7-diarylaminobenzimidazoles. The novel synthesis of 7-arylaminobenzimidazoles culminated in the identification of compounds exhibiting inhibitory activities comparable to the alkyl analog 1...
October 1, 2016: Bioorganic & Medicinal Chemistry
Francesco Meghini, Torcato Martins, Xavier Tait, Kazuyuki Fujimitsu, Hiroyuki Yamano, David M Glover, Yuu Kimata
A multi-subunit ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C), regulates critical cellular processes including the cell cycle. To accomplish its diverse functions, APC/C activity must be precisely regulated in time and space. The interphase APC/C activator Fizzy-related (Fzr or Cdh1) is localized at centrosomes in animal cells. However, neither the mechanism of its localization nor its importance is clear. Here we identify the centrosome component Spd2 as a major partner of Fzr in Drosophila...
2016: Nature Communications
Misato Amaki, Kazuhito Yajima, Yoshiaki Iwasaki, Yuu Ken, Ryouki Oohinata, Akifumi Imamura
A 64-year-old man with advanced gastric cancer presented with chief complaints of chest pain. His preoperative blood examination revealed positive results for serum HIV-antibody. His HIV-RNA level was 1.0×10 / 5 copies/mL, and his CD4lymphocyte count was 491 cell/mL; the patient was diagnosed with advanced gastric cancer and HIV infection. Distal gastrectomy with D2 lymphadenectomy and Roux-en-Y reconstruction were performed for treatment of the gastric cancer. Pathological examination revealed T3(SS)N3aM0, Stage III C cancer...
August 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Yi-Hsin Wang, Ke-Min Chen, Ping-Sung Chiu, Shih-Chan Lai, Hsing-Hui Su, Ming-Shiou Jan, Chia-Wei Lin, Dah-Yuu Lu, Yuan-Tsung Fu, Jiuan-Miaw Liao, Jinghua Tsai Chang, Shiang-Suo Huang
Lumbrokinase, a novel antithrombotic agent, purified from the earthworm Lumbricus rubellus, has been clinically used to treat stroke and cardiovascular diseases. However, inflammatory responses associated with the cardioprotective effect of lumbrokinase remain unknown. In this study, the signaling pathways involved in lumbrokinase-inhibited expressions of inflammation mediators were investigated in rats subjected to myocardial ischemia-reperfusion (I-R) injury. The left main coronary artery of anesthetized rats was subjected to 1h occlusion and 3h reperfusion...
August 5, 2016: Journal of Molecular and Cellular Cardiology
Yoshihiro Furuichi, Takuji Gotoda, Fuminori Moriyasu, Saori Ogawa, Yoshitaka Kasai, Hirohito Takeuchi, Yuu Yoshimasu, Takatomo Sano, Katsutoshi Sugimoto, Takashi Kawai, Yoshiyuki Kobayashi, Ikuo Nakamura, Takao Itoi
BACKGROUND: Dual red imaging (DRI) is a new technology that can increase the visibility of deeper veins compared with narrow band imaging (NBI). As esophageal varices (EVs) are a vascular disease occurring in the submucosal layer, their visibility might be increased by DRI. We prospectively clarified whether the visibility of EVs with red color sign (RCS) can be increased by DRI, and clarified the relation between the visibility scores and the obtained endoscopic ultrasound (EUS) images...
August 8, 2016: Journal of Gastroenterology
Seiichiro Katagiri, Tetsuzo Tauchi, Yuu Saito, Tamiko Suguro, Michiyo Asano, Seiichiro Yoshizawa, Juri Sakuta, Daigo Akahane, Yuko Tanaka, Nahoko Furuya, Keiko Ando, Hiroaki Fujimoto, Seiichi Okabe, Moritaka Gotoh, Yoshikazu Ito, Kazuma Ohyashiki
We conducted a questionnaire survey to assess the state of patients with CML after discontinuation of TKI therapy. Nine of 27 patients developed musculoskeletal pain after TKI discontinuation. One had discontinued nilotinib and eight had discontinued imatinib therapy. Median time to symptom development after discontinuation was 2 weeks. Four experienced grade 3 symptoms as per the CTCAE ver. 4.0. One had pain persisting over a period of 21 months. There was a significant difference between patients with and without symptoms as regards female gender and the probability of persistent MMR...
July 2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Kyosuke Uno, Yuu Kikuchi, Mina Iwata, Takashi Uehara, Tadasu Matsuoka, Tomiki Sumiyoshi, Yoshinori Okamoto, Hideto Jinno, Tatsuyuki Takada, Yoko Furukawa-Hibi, Toshitaka Nabeshima, Yoshiaki Miyamoto, Atsumi Nitta
The number of patients with schizophrenia has increased over the past decade. Previously, many studies have been performed to establish its diagnostic criteria, prophylactic methods, and effective therapies. In this study, we analyzed whether the ratios of DNA methylation in CpG islands of the Shati/Nat8l is decreased in model mice of schizophrenia-like phenotype using genomic DNA collected from brain regions and peripheral blood, since the mouse model of schizophrenia-like phenotype, mice treated repeatedly with methamphetamine showed increase of Shati/Nat8l mRNA expression in our previous experiment...
2016: PloS One
Baongoc Nasri, Ken Yuu, Masanori Tada
BACKGROUND: Most ingested foreign bodies pass uneventfully through the digestive tract without any major disturbances. OBJECTIVES: We reports a rare case of successful localization and surgical removal of needles in the gastrointestinal tract using C-arm fluoroscopy intraoperatively. CASE REPORT: A 46year old female, a non-hospitalized psychiatric patient, presented with acute abdominal pain. Imaging showed 16 needles all over the digestive tract...
2016: International Journal of Surgery Case Reports
Koki Kuramochi, Kohsuke Uchimura, Atsushi Kurata, Tohru Kobayashi, Yuu Hirose, Takeshi Miura, Noriaki Kishimoto, Ron Usami, Koki Horikoshi
An endo β-1,4-xylanase (XynE15) from a culture broth of a deep subseafloor microorganism, Microcella alkaliphila JAM-AC0309, was purified to homogeneity. The molecular mass of XynE15 was approximately 150 kDa as judged by SDS-PAGE. The optimal pH and temperature for hydrolysis of xylan were pH 8 and 65 °C. The enzyme was stable to incubation for 30 min at up to 75 °C, and the half-life at 50 °C was 48 h. XynE15 hydrolyzed arabinoxylan, oat spelt xylan, and birchwood xylan well, but not avicel, carboxymethylcellulose, or arabinan...
July 2016: Extremophiles: Life Under Extreme Conditions
Masatoshi Kanda, Hiroyuki Yamanaka, Satoshi Kojo, Yuu Usui, Hiroaki Honda, Yusuke Sotomaru, Michishige Harada, Masaru Taniguchi, Nao Suzuki, Tatsuya Atsumi, Haruka Wada, Muhammad Baghdadi, Ken-Ichiro Seino
Invariant natural killer T (iNKT) cells are a subset of innate-like T cells that act as important mediators of immune responses. In particular, iNKT cells have the ability to immediately produce large amounts of IFN-γ upon activation and thus initiate immune responses in various pathological conditions. However, molecular mechanisms that control IFN-γ production in iNKT cells are not fully understood. Here, we report that basic helix-loop-helix transcription factor family, member e40 (Bhlhe40), is an important regulator for IFN-γ production in iNKT cells...
June 14, 2016: Proceedings of the National Academy of Sciences of the United States of America
Toshihiko Tomita, Yuu Kato, Mayumi Takimoto, Takahisa Yamasaki, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Yoko Yokoyama, Hisatomo Ikehara, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Shigemi Tanaka, Masayuki Shima, Jiro Watari, Hiroto Miwa
Background/Aims: Few studies are available that investigated the risk factor for overlapping irritable bowel syndrome (IBS)-like symptoms in patients with inactive Inflammatory bowel disease (IBD). The present study had 3 objectives: (1) to assess the prevalence of IBS-like symptoms in Japanese patients with inactive IBD using Rome III criteria, (2) to examine the relationship of IBS-like symptoms to health related quality of life (HR-QOL), and (3) to investigate associations for developing IBS-like symptoms in patients with inactive IBD...
May 18, 2016: Journal of Neurogastroenterology and Motility
Yasuhiro Nishikawa, Saki Nakano, Yuu Tahira, Kanako Terazawa, Ken Yamazaki, Chitoshi Kitamura, Osamu Hara
Chiral pyridinium phosphoramide 1·HX was designed to be a new class of chiral Brønsted acid catalyst in which both the pyridinium proton and the adjacent imide-like proton activated by the electron-withdrawing pyridinium moiety could work cooperatively as strong dual proton donors. The potential of 1·HX was shown in the enantioselective Diels-Alder reactions of 1-amino dienes with various dienophiles including N-unsubstituted maleimide, which has yet to be successfully used in an asymmetric Diels-Alder reaction...
May 6, 2016: Organic Letters
Mami Ogimoto, Kumi Suzuki, Nahoko Haneishi, Yuu Kikuchi, Mayu Takanashi, Naoko Tomioka, Yoko Uematsu, Kimio Monma
Aluminium (Al) levels of 90 food samples were investigated. Nineteen samples contained Al levels exceeding the tolerable weekly intake (TWI) for young children [body weight (bw): 16 kg] when consuming two servings/week. These samples were purchased multiple times at specific intervals and were evaluated for Al levels. Al was detected in 27 of the 90 samples at levels ranging from 0.01 (limit of quantitation) to 1.06 mg/g. Of these, the Al intake levels in two samples (cookie and scone mix, 1.3 and 2 mg/kg bw/week, respectively) exceeded the TWI as established by European Food Safety Authority, although the level in the scone mix was equivalent to the provisional TWI (PTWI) as established by Joint Food and Agriculture Organization of the United Nations/World Health Organization Expert Committee on Food Additives...
September 2016: Food Additives & Contaminants. Part B, Surveillance
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"