keyword
https://read.qxmd.com/read/38537210/treatment-of-bone-metastases-of-breast-cancer-with-177lu-dota-iba
#1
JOURNAL ARTICLE
Jia Deng, Jian Yang, Zixuan Cheng, Yue Chen
Bone metastasis of breast cancer often presents as osteolytic. 177Lu-DOTA-ibandronic acid (177Lu-DOTA-IBA) is a new radioactive drug for bone metastasis lesion. We report a case of recurrent intermittent pain due to bone metastasis, who demonstrated a satisfactory therapy response after 2 cycles of 177Lu-DOTA-IBA. In addition, the patient did not have any observable adverse effects.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38536856/factors-associated-with-the-uptake-of-intermittent-preventive-treatment-for-malaria-during-pregnancy-in-cameroon-an-analysis-of-data-from-the-2018-cameroon-demographic-and-health-survey
#2
JOURNAL ARTICLE
Dominique Ken Guimsop, Ange Faustine Kenmogne Talla, Haoua Kodji, Jerome Ateudjieu
Malaria in pregnancy is a major public health concern that contributes to a significant increase in maternal and child mortality and morbidity. Intermittent preventive treatment of malaria during pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) is a key intervention recommended by the World Health Organization (WHO) and implemented in Cameroon to reduce the morbidity associated with malaria during pregnancy. This study aimed to assess the distribution of the poor uptake of IPTp-SP (i.e. fewer than three doses) in Cameroon and the factors associated...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536764/refractive-error-change-and-overminus-lens-therapy-for-childhood-intermittent-exotropia
#3
JOURNAL ARTICLE
Angela M Chen, S Ayse Erzurum, Danielle L Chandler, Amra Hercinovic, Rui Wu, Marilyn Vricella, Amy L Waters, Benjamin H Ticho, John W Erickson, Silvia Han, Paula S McDowell, Zhuokai Li, Raymond T Kraker, Jonathan M Holmes, Susan A Cotter
IMPORTANCE: Increased myopic shift was found to be associated with 1 year of overminus spectacle treatment for children with intermittent exotropia (IXT). Persistence of myopic shift after discontinuing overminus spectacles is unknown. OBJECTIVE: To compare refractive error change over 3 years in children with IXT originally treated with overminus vs nonoverminus spectacles. DESIGN, SETTING, AND PARTICIPANTS: This study was an 18-month extension of the Trial of Overminus Spectacle Therapy for Intermittent Exotropia cohort, which previously randomized children aged 3 to 10 years with IXT and baseline spherical equivalent refractive error (SER) between -6...
March 21, 2024: JAMA Ophthalmology
https://read.qxmd.com/read/38536751/elasticity-and-rheology-of-auxetic-granular-metamaterials
#4
JOURNAL ARTICLE
Daan Haver, Daniel Acuña, Shahram Janbaz, Edan Lerner, Gustavo Düring, Corentin Coulais
The flowing, jamming, and avalanche behavior of granular materials is satisfyingly universal and vexingly hard to tune: A granular flow is typically intermittent and will irremediably jam if too confined. Here, we show that granular metamaterials made from particles with a negative Poisson's ratio yield more easily and flow more smoothly than ordinary granular materials. We first create a collection of auxetic grains based on a re-entrant mechanism and show that each grain exhibits a negative Poisson's ratio regardless of the direction of compression...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38536726/intermittent-fasting-promotes-type-3-innate-lymphoid-cells-secreting-il-22-contributing-to-the-beigeing-of-white-adipose-tissue
#5
JOURNAL ARTICLE
Hong Chen, Lijun Sun, Lu Feng, Xue Han, Yunhua Zhang, Wenbo Zhai, Zehe Zhang, Michael Mulholland, Weizhen Zhang, Yue Yin
Mechanism underlying the metabolic benefit of intermittent fasting remains largely unknown. Here, we reported that intermittent fasting promoted interleukin-22 (IL-22) production by type 3 innate lymphoid cells (ILC3s) and subsequent beigeing of subcutaneous white adipose tissue. Adoptive transfer of intestinal ILC3s increased beigeing of white adipose tissue in diet-induced-obese mice. Exogenous IL-22 significantly increased the beigeing of subcutaneous white adipose tissue. Deficiency of IL-22 receptor (IL-22R) attenuated the beigeing induced by intermittent fasting...
March 27, 2024: ELife
https://read.qxmd.com/read/38536678/dynamic-peripheral-hemoperfusion-distribution-monitoring-based-on-janus-flexible-sensor-system
#6
JOURNAL ARTICLE
Chenxiao Huang, Ouyang He, Zhechen Lao, Hanhao Liu, Yanlong Leng, Xuanhao Xu, Shuai Tian, Yawei Wang, Guifu Wu, Ruya Li, Yubo Fan
OBJECTIVE: Peripheral vascular disease is a worldwide leading health concern. Real-time peripheral hemoperfusion monitoring during treatment is essential to plan treatment strategies to improve circulatory enhancement effects. METHODS: The present work establishes a Janus flexible perfusion (JFP) sensor system for dynamic peripheral hemoperfusion monitoring. We develop a Janus structure design with different Young's modulus to improve the mechanical properties for motion artifacts suppression...
March 27, 2024: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/38535729/does-grappling-combat-sports-experience-influence-exercise-tolerance-of-handgrip-muscles-in-the-severe-intensity-domain
#7
JOURNAL ARTICLE
Rubens Correa Junior, Renan Vieira Barreto, Anderson Souza Oliveira, Camila Coelho Greco
Successful performance in grappling combat sports (GCS) can be influenced by the fighter's capacity to sustain high-intensity contractions of the handgrip muscles during combat. This study investigated the influence of GCS experience on the critical torque (CT), impulse above CT (W'), tolerance, and neuromuscular fatigue development during severe-intensity handgrip exercise by comparing fighters and untrained individuals. Eleven GCS fighters and twelve untrained individuals participated in three experimental sessions for handgrip muscles: (1) familiarization with the experimental procedures and strength assessment; (2) an all-out test to determine CT and W'; and (3) intermittent exercise performed in the severe-intensity domain (CT + 15%) until task failure...
February 21, 2024: Sports
https://read.qxmd.com/read/38535536/supportive-treatment-of-a-dog-with-leishmaniosis-and-severe-glomerulopathy-with-immunoadsorption
#8
Florian Sänger, Michèle Bergmann, Katrin Hartmann, René Dörfelt
A three-year-old, intact female mix-breed dog, weighing 30 kg, was presented due to vomitus and diarrhea. At presentation, the patient had a slightly reduced general condition and moderately enlarged mandibular and popliteal lymph nodes. The initial blood work showed severe azotemia and hypoalbuminemia. In the urinalysis, marked proteinuria with a urine protein/creatinine ratio (UPC) of 4.69 was found. Further workup showed a high leishmania antibody titer. The dog was diagnosed with leishmaniosis and glomerulonephritis...
February 21, 2024: Pathogens
https://read.qxmd.com/read/38535494/xenobiotics-triggering-acute-intermittent-porphyria-and-their-effect-on-mouse-brain-respiratory-complexes
#9
JOURNAL ARTICLE
Johanna Romina Zuccoli, María Del Carmen Martínez, Pablo Vallecorsa, Ana María Buzaleh
Heme enzyme dysfunction causes a group of diseases called porphyrias. Particularly, a decrease in porphobilinogen deaminase, involved in the third step of heme biosynthesis, leads to acute intermittent porphyria (AIP). Considering our previous works demonstrating the multiplicity of brain metabolisms affected by porphyrinogenic agents, this study aimed to elucidate whether they cause any alteration on the mitochondrial respiratory chain. The activities of respiratory chain complexes (I to IV) were measured in encephalon mitochondria of CF1 male mice receiving volatile anesthetics: isoflurane (2 mL/kg) and sevoflurane (1...
February 27, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535090/machine-learning-identifies-higher-survival-profile-in-extracorporeal-cardiopulmonary-resuscitation
#10
JOURNAL ARTICLE
Ruben Crespo-Diaz, Julian Wolfson, Demetris Yannopoulos, Jason A Bartos
OBJECTIVES: Extracorporeal cardiopulmonary resuscitation (ECPR) has been shown to improve neurologically favorable survival in patients with refractory out-of-hospital cardiac arrest (OHCA) caused by shockable rhythms. Further refinement of patient selection is needed to focus this resource-intensive therapy on those patients likely to benefit. This study sought to create a selection model using machine learning (ML) tools for refractory cardiac arrest patients undergoing ECPR. DESIGN: Retrospective cohort study...
March 27, 2024: Critical Care Medicine
https://read.qxmd.com/read/38534664/efficacy-of-continuous-vs-intermittent-administration-of-cefepime-in-adult-icu-patients-with-gram-negative-bacilli-bacteremia-a-randomized-double-blind-clinical-study
#11
JOURNAL ARTICLE
Carlos Arturo Álvarez-Moreno, Laura Cristina Nocua-Báez, Guillermo Ortiz, Juan Carlos Torres, Gabriel Montenegro, Williams Cervera, Luis Fernando Zuluaga, Alonso Gómez
INTRODUCTION: The objective of this study was to compare the continuous infusion of cefepime with the intermittent infusion in patients with sepsis caused by Gram-negative bacilli (GNB). METHODS: Randomized 1:1 multicenter double-blinded placebo-controlled study with allocation concealment; multicenter study in the intensive care units of Colombia. Patients with sepsis, severe sepsis or septic shock, and GNB-suspected bacteremia. Cefepime was administered for 7 to 14 days over 30 m intermittently every 8 h over 24 h plus continuous saline solution (0...
February 29, 2024: Antibiotics
https://read.qxmd.com/read/38534340/mechanical-stress-induces-sodium-entry-and-osmoprotective-responses-in-murine-synovial-fibroblasts
#12
JOURNAL ARTICLE
Annemarie Proff, Ute Nazet, Agnes Schröder, Jonathan Jantsch
Osteoarthritis (OA) is a multifactorial disease depending on molecular, genetic, and environmental factors like mechanical strain. Next to the cartilage and the subchondral bone, OA also affects the synovium, which is critically involved in the maintenance of joint homeostasis. As there is a correlation between the extracellular sodium content in the knee joint and OA, this study investigates the impact of sodium on OA-associated processes like inflammation and bone remodeling without and with mechanical loading in synovial fibroblasts...
March 13, 2024: Cells
https://read.qxmd.com/read/38534092/mitochondrial-respiration-in-peripheral-arterial-disease-depends-on-stage-severity
#13
JOURNAL ARTICLE
Fiona Speichinger, Alexandra Gratl, Ben Raude, Larissa Schawe, Jan Carstens, Nina A Hering, Andreas Greiner, Dominik Pesta, Jan Paul Frese
Peripheral arterial disease (PAD) is an increasing cause of morbidity and its severity is graded based on clinical manifestation. To investigate the influence of the different stages on myopathy of ischemic muscle we analysed severity-dependent effects of mitochondrial respiration in PAD. Eighteen patients with severe PAD, defined as chronic limb-threatening ischemia, 47 patients with intermittent claudication (IC) and 22 non-ischemic controls were analysed. High-resolution respirometry (HRR) was performed on muscle biopsies of gastrocnemius and vastus lateralis muscle of patients in different PAD stages to investigate different respiratory states...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38533360/clinical-relevance-of-cluster-analysis-in-phenotyping-allergic-rhinitis-in-the-paediatric-population-of-the-kuyavian-pomeranian-voivodeship-poland
#14
JOURNAL ARTICLE
Agnieszka Kowalczyk, Aneta Krogulska
INTRODUCTION: Allergic rhinitis (AR) is the most common allergic disease in the world, and additionally, its prevalence is successively increasing. Children with AR constitute a heterogeneous group of patients differing both in the course of AR and in the frequency of asthma coexistence. It is possible to identify children with AR at risk of a more severe course of the disease by analysing the potential family, environmental and clinical factors related to the development of the disease; the findings will help identify patients with a higher risk of developing asthma in the future, and who will benefit the most from early allergen-specific immunotherapy...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38533333/effects-of-aeration-modes-and-rates-on-nitrogen-conversion-and-bacterial-community-in-composting-of-dehydrated-sludge-and-corn-straw
#15
JOURNAL ARTICLE
Yuyun Wang, PengXiang Xu, Yue Wang, Jing Su, Zhi Xu, Zhengbo Jiang, Yuquan Wei, Sheng Hang, Xiaoyan Ding, Hao Zhang, Longli Zhang, Yongdi Liu, Ji Li
Aeration is an important factor to regulate composting efficiency and nitrogen loss. This study is aimed to compare the effects of different aeration modes (continuous and intermittent) and aeration rate on nitrogen conversion and bacterial community in composting from dehydrated sludge and corn straw. Results showed that the intermittent aeration mode at same aeration volume was superior to the continuous aeration mode in terms of NH3 emission reduction, nitrogen conversion and germination index (GI) improvement...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38533155/granulocyte-colony-stimulating-factor-g-csf-induced-aortitis-a-case-report
#16
Masahiro Ito, Masakazu Amari, Akiko Sato, Masahiro Hikichi
Pegylated granulocyte colony-stimulating factor (G-CSF), commonly used in chemotherapy-induced neutropenia, has been associated with rare instances of aortitis. This study describes a 67-year-old female patient with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2-positive breast cancer, undergoing chemotherapy with an epirubicin/cyclophosphamide (EC) regimen (epirubicin, cyclophosphamide) and pegylated G-CSF for neutropenia prophylaxis. Post-treatment, she developed symptoms including intermittent fever and severe arthralgia...
February 2024: Curēus
https://read.qxmd.com/read/38532861/benefits-of-a-clinical-pathway-in-total-knee-arthroplasty
#17
JOURNAL ARTICLE
Márcio de Castro Ferreira, Gilvânia Silva, Carolina Padrão Amorim Marinelli, Julia Souza de Oliveira, Pedro Aurélio Mathiasi, Gilberto Luis Camanho
OBJECTIVE: Demonstrate whether a multiprofessional Clinical Pathway Program in Total Knee Arthroplasty (CPPA) contributesto optimizing hospital care. METHOD: Retrospective study of medical data of care indicators in 310 patients divided into two groups: A- who underwent arthroplasty in the last biennium before the introduction of the CPPA (n=144) and group B- who underwent TKA in the biennium after the introduction of the CPPA (n=166). RESULTS: Postoperative showed a significant difference in favor of group B over group A for hospitalization time in days 4...
2024: Acta Ortopedica Brasileira
https://read.qxmd.com/read/38532622/a-nomogram-for-predicting-the-risk-of-deep-vein-thrombosis-in-patients-with-acute-ischemic-stroke-during-the-covid-19
#18
JOURNAL ARTICLE
Jie Zhang, Shurui Zhang, Ge Song, Shimeng Zhuang, Hua Li, Lisi An, Yan Meng, Jiayu Fan, Lijuan Wang
Deep vein thrombosis (DVT) is an important complication of stroke. As coronavirus disease 2019 (COVID-19) enters the stage of persistent and long-term management, the clinical management of DVT in stroke patients may require adjustment. The present study evaluated whether there was an increased risk of DVT in stroke patients during the COVID-19 period. Furthermore, we analyzed the possible risk factors and developed an easy-to-use nomogram to predict DVT in stroke patients during the long-term management of COVID-19...
March 26, 2024: Angiology
https://read.qxmd.com/read/38532541/case-report-of-overlapping-pyloric-obstruction-due-to-dichlorvos-poisoning-and-cholelithiasis-with-choledocholithiasis
#19
JOURNAL ARTICLE
Jie Peng, Yalu Zhang, Qin Ling, Liang Zhu, Hanhui Yao
BACKGROUND Pyloric obstruction after dichlorvos poisoning causes repeated vomiting and inability to eat. Choledocholithiasis and cholelithiasis are the common digestive diseases, with high morbidity and relapse in elderly patients. However, the complex situation of these diseases' coexistence is a clinically intractable problem, and literature on selecting optimal surgical planning is scarce. CASE REPORT A thin 79-year-old woman took dichlorvos due to family conflicts. She improved after being urgently sent to local hospital for gastric lavage and detoxification...
March 27, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38531744/an-improved-laparoscopic-choledochojejunostomy-technique-with-video
#20
JOURNAL ARTICLE
Xingru Wang, Fei Chen, Qian Zhang, Jianwei Li
TECHNIQUE: Choledochojejunostomy is an important procedure in hepatobiliary pancreatic surgery. It is used in pancreaticoduodenectomy, biliary strictures, liver transplantation, and other surgical reconstructions involving bile duct resection. Safe and reliable anastomosis under laparoscopic guidance is important for good postoperative recoveries. There are some difficulties owing to the limited angle of laparoscopic instruments. Standardized anastomosis methods are currently lacking, especially for cases with thin bile duct walls and small diameters...
March 25, 2024: Asian Journal of Surgery
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