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https://www.readbyqxmd.com/read/29028762/intermittent-versus-continuous-and-intermittent-medications-for-pain-and-sedation-after-pediatric-cardiothoracic-surgery-a-randomized-controlled-trial
#1
Jamie S Penk, Cheryl A Lefaiver, Colleen M Brady, Christine M Steffensen, Kimberly Wittmayer
OBJECTIVES: Compare continuous infusions of morphine and midazolam in addition to intermittent doses with an intermittent only strategy for pain and sedation after pediatric cardiac surgery. DESIGN: Randomized controlled trial. SETTING: Advocate Children's Hospital, Oak Lawn, IL. PATIENTS: Sixty patients 3 months to 4 years old with early extubation after pediatric cardiac surgery. INTERVENTIONS: Patients received a continuous infusion of morphine and midazolam or placebo for 24 hours...
October 12, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29028452/atrial-fibrillation-in-women-risks-and-management
#2
Sindhu Prabakaran, Maria Carolina Gongora Nieto, Gina Lundberg
Atrial fibrillation (AF) is one of the most commonly occurring arrhythmias and a major modifiable risk factor for stroke, especially in women. While its prevalence is similar in both men and women, women unfortunately face a greater intrinsic AF-related risk of stroke than men do. This is likely one of the reasons that more women than men die from strokes, in addition to experiencing more new and recurrent strokes. Therefore, in women especially, it is imperative to diagnose and treat AF as early as possible...
October 13, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29027128/continuous-infusion-versus-intermittent-bolus-of-beta-lactams-in-critically-ill-patients-with-respiratory-infections-a-systematic-review-and-meta-analysis
#3
REVIEW
Young R Lee, Pamela D Miller, Saeed K Alzghari, Delilah D Blanco, Jackson D Hager, Kailey S Kuntz
BACKGROUND: Critically ill patients display altered pharmacokinetics and pharmacodynamics and are more likely to be infected with more resistant pathogens. Beta-lactam antibiotics exhibit time-dependent pharmacodynamics; therefore, it is postulated that continuous infusion (CI) may optimize these parameters. OBJECTIVE: To perform a systematic review and meta-analysis of the available literature comparing CI versus intermittent bolus (IB) of beta-lactam antibiotics in critically ill adult patients with respiratory infections to determine if clinical benefits exist...
October 12, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29026845/osteonecrosis-of-the-jaws-in-patient-received-bisphosphonates-and-sunitinib-separately-a-case-report
#4
Farzaneh Ashrafi, Ali Derakhshandeh, Bijan Movahedian, Azadeh Moghaddas
Recently published reports have suggested that antiangiogenic drugs such as sunitinib could potentiate the osteonecrosis of the jaw (ONJ) induced by bisphosphonates (BPs) and even induce this adverse effect per se. We reported a case of ONJ with renal cell carcinoma under sunitinib medication and history of BPs therapy. A 53-year-old man was referred to the oral surgery clinic complaining of painful exposed oral lesion and bone extraction from right lower jaw in the mouth. He underwent nephrectomy followed by 5 months treatment with cycles of 50 mg sunitinib (Sutent(®)) once a day for 4 weeks followed by 2 weeks drug free before lesion exposure in October 2016...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29026668/fourth-ventricle-neurocysticercosis-rigid-endoscopic-management-description-of-direct-transcerebellar-approach
#5
A Ceja-Espinosa, J A Franco-Jiménez, A Sosa-Nájera, G A Gutiérrez-Aceves, M I Ruiz-Flores
BACKGROUND: Endoscopy has gained a crucial role in high specialty neurosurgery during the last decades. At present, there are well-defined flexible neuroendoscopic procedures to treat ventricular and subarachnoid space pathologies. Neurocysticercosis is recognized as a common cause of neurologic disease in developing countries and the United States. Surgical intervention, especially cerebrospinal fluid diversion, is the key for management of hydrocephalus. In 2002, a consensus suggested that ventricular forms should be treated with endoscopy as the first option...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29024799/treatment-for-uterine-isthmocele-a-pouch-like-defect-at-the-site-of-cesarean-section-scar
#6
REVIEW
Antonio Setubal, João Alves, Filipa Osório, Adalgisa Guerra, Rodrigo Fernandes, Jaime Albornoz, Zacharoula Sidiroupoulou
Isthmocele appears as a fluid pouch-like defect in the anterior uterine wall at the site of a prior Cesarean section and ranges in prevalence from 19% to 84%, a direct relation to the increase in Cesarean sections performed worldwide. Many definitions have been suggested for the dehiscence resulting from Cesarean section, and we propose standardization with a single term for all cases: isthmocele. Patients are not always symptomatic, but symptoms typically include intermittent abnormal bleeding, pain, and infertility...
October 9, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29024603/exercise-tolerance-during-muscle-contractions-below-and-above-the-critical-torque-in-different-muscle-groups
#7
Leonardo Henrique Perinotto Abdalla, Benedito Sérgio Denadai, Natalia Menezes Bassan, Camila Coelho Greco
The objective of this study was to test the hypotheses that end-test torque (ET) (expressed as % maximal voluntary contraction - MVC) is higher for plantar flexors (PF) than knee extensors (KE) muscles, whereas impulse above ET (IET) is higher for KE than PF. Thus, we expected that exercise tolerance would be longer for KE than PF only during the exercise performed above ET. After the determination of MVC, forty men performed two 5-min all-out tests to determine ET and IET. Eleven participants performed a further four intermittent isometric tests, to exhaustion, at ET + 5% and ET - 5%, and one test for KE at the exercise intensity (%MVC) corresponding to ET + 5% of PF...
October 12, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29024200/novel-automated-point-collection-software-facilitates-rapid-high-density-electroanatomical-mapping-with-multiple-catheter-types
#8
Leon M Ptaszek, Boyce Moon, Guy Rozen, Srijoy Mahapatra, Moussa Mansour
INTRODUCTION: Manual, point-by-point electroanatomical mapping requires the operator to directly evaluate each point during map construction. Consequently, point collection can be a slow process. An automated 3D mapping system was developed with the goal of improving key mapping metrics, including map completion time and point density. METHODS: Automated 3D mapping software that includes morphology and cycle length discrimination functions for surface and intracardiac electrograms was developed...
October 12, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29023635/intermittent-gait-disturbance-in-idiopathic-normal-pressure-hydrocephalus
#9
Y Nikaido, Y Kajimoto, A Tucker, K Kuroda, H Ohno, T Akisue, R Saura, T Kuroiwa
OBJECTIVES: We identified intermittent gait disturbance (IGD) observed in the mild stage of idiopathic normal pressure hydrocephalus (iNPH). The first purpose of this study was to clarify the temporal gait profile of IGD during long-distance gait. The second purpose was to confirm the difference in treatment effect after cerebrospinal fluid (CSF) shunting in patients with and without IGD. MATERIALS AND METHODS: Fourteen consecutive iNPH patients with mild gait disturbance with a timed up-and-go (TUG) of <20 seconds were prospectively enrolled in the study...
October 11, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29023329/living-and-training-at-825m-for-8-weeks-supplemented-with-intermittent-hypoxic-training-at-3000m-improves-blood-parameters-and-running-performance
#10
Preetiwat Wonnabussapawich, Michael J Hamlin, Catherine A Lizamore, Nuttaset Manimmanakorn, Naruemon Leelayuwat, Orathai Tunkamnerdthai, Worrawut Thuwakum, Apiwan Manimmanakorn
We aimed to investigate the effect of an 8-week low-altitude training block supplemented with intermittent hypoxic training, on blood and performance parameters in soccer players. Forty university-level male soccer players were separated into altitude (n = 20, 825m) or sea level (n = 20, 125m) groups. Before (1-2 days prior) and after (1 and 14 days post) training, players were asked to give a resting venous blood sample and complete a series of performance tests. Compared to sea level, the altitude group increased erythropoietin, red cell count and hematocrit 1 day post training (42...
October 10, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29022648/probiotics-for-experimental-obesity-prevention-focus-on-strain-dependence-and-viability-of-composition
#11
Nazarii Kobyliak, Tetyana Falalyeyeva, Tetyana Beregova, Mykola Spivak
INTRODUCTION: a comparative animal study of the efficacy of intermittent short-course administration of lyophilised single-, three-, and live multistrain probiotic on obesity. METHODS: We included 70 rats divided into seven groups (n = 10 in each). Rats of group I were intact. Newborn rats of groups II-VII were injected with monosodium glutamate (MSG) (4 mg/g). Rats of group II (MSG-obesity group) were untreated. The group III-V received lyophilised monoprobiotics B...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29021912/a-study-of-intensity-fatigue-and-precision-in-two-specific-interval-trainings-in-young-tennis-players-high-intensity-interval-training-versus-intermittent-interval-training
#12
David Suárez Rodríguez, Miguel Del Valle Soto
BACKGROUND: The aim of this study is to find the differences between two specific interval exercises. We begin with the hypothesis that the use of microintervals of work and rest allow for greater intensity of play and a reduction in fatigue. METHODS: Thirteen competition-level male tennis players took part in two interval training exercises comprising nine 2 min series, which consisted of hitting the ball with cross-court forehand and backhand shots, behind the service box...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29021883/brodie-s-abscess-of-posterior-ilium-with-gluteal-syndrome-an-unusual-cause-of-paediatric-low-back-pain-a-case-report
#13
G Behera, M Poduval, D K Patro, S Sahoo
Brodie's abscess is a variety of subacute osteomyelitis with a long duration of presentation and intermittent pain. It usually involves the metaphyseal region of long bones of the lower limbs. Brodie's abscess of pelvic bone is very rare. Involvement of posterior ilium with gluteal syndrome is extremely unusual and can be easily missed or misdiagnosed. We present a 9-year old boy who reported to us with intermittent low back pain of three months duration without any other constitutional symptoms. Clinically, there was mild tenderness over the posterior ilium...
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29021707/pectinase-treated-panax-ginseng-protects-against-chronic-intermittent-heat-stress-induced-testicular-damage-by-modulating-hormonal-and-spermatogenesis-related-molecular-expression-in-rats
#14
Spandana Rajendra Kopalli, Kyu-Min Cha, Sang-Ho Lee, Ji-Hoon Ryu, Seock-Yeon Hwang, Min-Sik Jeong, Jong-Hwan Sung, Si-Kwan Kim
BACKGROUND: Elevated testicular temperature disrupts spermatogenesis and causes infertility. In the present study, the protective effect of enzymatically biotransformed Panax ginseng Meyer by pectinase (GINST) against chronic intermittent heat stress-induced testicular damage in rats was investigated. METHODS: Male Sprague-Dawley rats (4 wk old, 60-70 g) were divided into four groups: normal control (NC), heat-stress control (HC), heat-stress plus GINST-100 mg/kg (HG100), and heat-stress plus GINST-200 mg/kg (HG200) treatment groups...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021649/follow-up-urodynamics-in-patients-with-neurogenic-bladder
#15
REVIEW
Sanjay Sinha
INTRODUCTION: Neurogenic bladder patients are at long-term risk of secondary upper urinary tract damage. Symptoms are unreliable and follow-up urodynamics is the only method of ascertaining safety of bladder pressures. This review examines the recommendations, shortcomings and utilization of existing guidelines. The evidence with regard to follow-up urodynamics in different settings relevant to neurogenic bladder is evaluated and an algorithm is proposed. METHODS: A pubmed search was conducted for studies on follow-up urodynamics in patients with neurogenic bladder...
October 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29021191/enhancement-of-phrenic-long-term-facilitation-following-repetitive-acute-intermittent-hypoxia-is-blocked-by-the-glycolytic-inhibitor-2-deoxyglucose
#16
Peter M MacFarlane, Stephane Vinit, Gordon S Mitchell
Moderate acute intermittent hypoxia (mAIH) elicits a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF). Preconditioning with modest protocols of chronic intermittent hypoxia enhances pLTF, demonstrating pLTF metaplasticity. Since "low dose" protocols of repetitive acute intermittent hypoxia show promise as a therapeutic modality to restore respiratory (and non-respiratory) motor function in clinical disorders with compromised breathing, we tested the hypothesis that preconditioning with a mild repetitive AIH (rAIH) protocol enhances pLTF and hypoglossal (XII) LTF, and whether the enhancement is regulated by glycolytic flux...
October 11, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29021143/cold-agglutinins-in-a-patient-undergoing-normothermic-cardiac-operation-with-warm-cardioplegia
#17
Tatsuhiko Ogawa
Cold agglutinins are autoantibodies that agglutinate red blood cells at low temperatures, leading to haemagglutination and haemolysis. They are generally of no clinical significance. However, when people with cold agglutinins undergo cardiac operation with hypothermia and cold cardioplegia, they can experience complications. Thus, different perioperative management is required for such patients. We describe a 74-year-old man with cold agglutinins incidentally detected on the preoperative screening test. He had never experienced any complications or developed a haematological disease...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29020057/high-dose-teriparatide-rpth1-34-therapy-increases-callus-volume-and-enhances-radiographic-healing-at-8-weeks-in-a-massive-canine-femoral-allograft-model
#18
Kohei Nishitani, Zachary Mietus, Christopher A Beck, Hiromu Ito, Shuichi Matsuda, Hani A Awad, Nicole Ehrhart, Edward M Schwarz
Small animal studies have demonstrated significant high-dose recombinant parathyroid hormone1-34 (rPTH1-34) effects on intercalary allograft healing. Towards a human adjuvant therapy to decrease non-unions, we evaluated rPTH1-34 safety and efficacy in a clinically relevant canine femoral allograft model. Adult female mongrel hounds (n = 20) received a 5cm mid-diaphyseal osteotomy reconstructed with a plated allograft, and were randomized to: 1) Placebo (n = 5; daily saline), 2) Continuous rPTH1-34 (n = 7; 5 μg/kg/day s...
2017: PloS One
https://www.readbyqxmd.com/read/29019293/evolution-of-the-concept-of-oxygen-transport-in-the-critically-ill-with-a-focus-on-children-after-cardiopulmonary-bypass
#19
Jia Li
The concept of oxygen transport, defined as the relation between oxygen consumption (VO2) and delivery (DO2), is of fundamental importance in critically ill patients. The past 200 years have witnessed a stepwise progressive improvement in the understanding of pathophysiological disturbances in the balance of DO2 and VO2 in critically ill patients including those after cardiopulmonary bypass surgery. Intermittent spectacular technological achievements have accelerated the rate of progress. Therapeutic advances have been particularly impressive during the recent decades...
October 11, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29018582/effect-of-low-dose-versus-higher-dose-antenatal-iron-supplementation-on-child-health-outcomes-at-36-months-of-age-in-viet-nam-longitudinal-follow-up-of-a-cluster-randomised-controlled-trial
#20
Sarah Hanieh, Tran T Ha, Julie A Simpson, Sabine Braat, Tran T Thuy, Thach D Tran, Janet King, Tran Tuan, Jane Fisher, Beverley-Ann Biggs
INTRODUCTION: Intermittent iron-folic acid supplementation (IFA) is currently recommended for pregnant women in populations where anaemia prevalence among pregnant women is <20% or if daily iron is not acceptable. The effect of providing lower doses of antenatal elemental iron through intermittent regimes on longer-term health outcomes in childhood is unclear. METHODS: A prospective cohort study conducted between May 2012 and May 2014 in Viet Nam among children of 36 months of age, born to women previously enrolled in a cluster randomised controlled trial of antenatal micronutrient supplementation (daily IFA (60 mg elemental iron) vs twice-weekly IFA (60 mg elemental iron) vs twice-weekly multiple micronutrient (MMN) supplementation (60 mg elemental iron))...
2017: BMJ Global Health
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