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https://www.readbyqxmd.com/read/29679609/cannabis-sativa-marijuana-alters-blood-chemistry-and-the-cytoarchitecture-of-some-organs-in-sprague-dawley-rat-models
#1
Nosarieme Omoregie Abey
There is evidence that Cannabis whose active ingredient is tetrahydrocannabinol (THC) is the most commonly abused neuroactive substance, among young adults. This work investigated the effects of Cannabis sativa on the cytoarchitecture of some key organs and the blood chemistry of rat models. Twenty-one (21) male Sprague Dawley rats were fed different percentage of cannabis chow (0%, 5% and 10%) for a period of seven (7) weeks. Rats were subjected to intermittent cognitive function test and sacrificed after the seventh week, collecting the blood, brain and other important tissues for analysis which include; brain total protein and nitric oxide concentration, blood chemistry and histopathology...
April 18, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29679288/calcium-chloride-mimics-the-effects-of-acamprosate-on-cognitive-deficits-in-chronic-alcohol-exposed-mice
#2
Grishma Pradhan, Patrick R Melugin, Fei Wu, Hannah M Fang, Rachel Weber, Sven Kroener
RATIONALE: Acamprosate (calcium-bis N-acetylhomotaurinate) is the leading medication approved for the maintenance of abstinence, shown to reduce craving and relapse in animal models and human alcoholics. Acamprosate can improve executive functions that are impaired by chronic intermittent ethanol (CIE) exposure. Recent work has suggested that acamprosate's effects on relapse prevention are due to its calcium component, which raises the question whether its pro-cognitive effects are similarly mediated by calcium...
April 20, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29679240/a-case-of-tension-faecopneumothorax-after-delayed-diagnosis-of-traumatic-diaphragmatic-hernia
#3
Tien Yew Chern, Allan Kwok, Soni Putnis
BACKGROUND: Traumatic diaphragmatic injuries from blunt or penetrating trauma are difficult to detect in the acute setting and, if missed, can result in significant morbidity and mortality in the future. We present a case demonstrating the natural progression of this resulting in faecopneumothorax, which is a rare but serious presentation. CASE PRESENTATION: A 22-year-old young man presented with left upper quadrant and chest pain, nausea, vomiting, and intermittent obstipation with a background of previous lower chest wall stabbings...
April 20, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29679130/effects-of-intermittent-aeration-periods-on-a-structured-bed-reactor-continuously-fed-on-the-post-treatment-of-sewage-anaerobic-effluent
#4
Bruno Garcia Silva, Márcia Helena Rissato Zamariolli Damianovic, Eugenio Foresti
This study assessed the simultaneous nitrification and denitrification processes and remaining organic matter removal from anaerobic reactor effluent treating wastewater in a single reactor. A structured-bed reactor, with polyurethane foam as support media, was subjected to intermittent aeration and effluent recirculation. Aerated/non-aerated periods varied in the range of 2/1-1/3 h. The chemical oxygen demand (COD) in the effluent remained between 26 and 42 mg L-1 throughout all the aeration conditions. Aeration periods of 1/2 h removed 80 and 26% of Total Kjeldahl Nitrogen and Total Nitrogen, respectively...
April 20, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29678995/intermittent-versus-continuous-oxygen-saturation-monitoring-for-infants-hospitalised-with-bronchiolitis-study-protocol-for-a-pragmatic-randomised-controlled-trial
#5
Sanjay Mahant, Gita Wahi, Lucy Giglia, Catherine Pound, Ronik Kanani, Ann Bayliss, Madan Roy, Mahmoud Sakran, Natascha Kozlowski, Karen Breen-Reid, Mollie Lavigne, Laila Premji, Myla E Moretti, Andrew R Willan, Suzanne Schuh, Patricia C Parkin
INTRODUCTION: Bronchiolitis is the most common reason for hospitalisation in infants in developed countries. The main focus of hospital care is on supportive care, such as monitoring for hypoxia and supplemental oxygen administration, as active therapies lack effectiveness. Pulse oximetry is used to monitor hypoxia in hospitalised infants and is used either intermittently or continuously. Observational studies have suggested that continuous pulse oximetry use leads to a longer length of hospital stay in stable infants...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678653/continued-ultrasound-surveillance-required-after-hand-ischemia-associated-with-trauma-in-children
#6
Melissa L Kirkwood, Khalil H Chamseddin, Brianne Hanson, Carlos H Timaran, Mujtaba Ali, Alexis D Jacob, John E Rectenwald
BACKGROUND: Hand ischemia following trauma in children is rare and the natural history after upper extremity arterial bypass in children is unknown. We hypothesize children with brachial artery repair are at long term risk of developing aneurysmal degeneration or Thrombosis thus necessitating annual duplex ultrasonography and physical examination. STUDY DESIGN: A retrospective review of children who had brachial artery repair (bypass or vein patch) for hand ischemia secondary to trauma at a level I trauma pediatric hospital was performed...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29678150/uptake-of-intermittent-preventive-treatment-for-malaria-during-pregnancy-with-sulphadoxine-pyrimethamine-iptp-sp-among-postpartum-women-in-zomba-district-malawi-a-cross-sectional-study
#7
Steven Chifundo Azizi, Gershom Chongwe, Helen Chipukuma, Choolwe Jacobs, Jessy Zgambo, Charles Michelo
BACKGROUND: Malaria in pregnancy causes adverse birth outcomes. Intermittent preventive treatment of malaria during pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) is recommended as a chemoprevention therapy. Zomba district IPTp uptake falls far below the national average. The study was conducted to assess determinants of IPTp-SP uptake during pregnancy among postpartum women in Zomba district after adoption of new IPTp-SP policy in 2014. METHODS: This was a cross-sectional survey...
April 20, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29678142/abnormally-low-bispectral-index-and-severe-hypoglycemia-during-maintenance-of-and-recovery-from-general-anesthesia-in-diabetic-retinopathy-surgery-two-case-reports
#8
Chunhua Xi, Chuxiong Pan, Tianzuo Li
BACKGROUND: Hypoglycemia is one of the most fatal complications during the perioperative period. General anesthesia or sedation can mask a hypoglycemia-altered mental status. Acute hypoglycemia might result in permanent brain injury. There is no way to detect hypoglycemia during general anesthesia, except for intermittent blood glucose monitoring. CASE PRESENTATION: Hypoglycemia is associated with changes in electroencephalogram readings. Here, we report two cases of patients with an abnormally low Bispectral Index (BIS) associated with diabetic retinopathy surgery, one in the recovery stage of general anesthesia and the other in the maintenance of general anesthesia...
April 20, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29677973/yorwalk-desiging-a-smartphone-exercise-application-for-people-with-intermittent-claudication
#9
Ahmed Shalan, Abubakar Abdulrahman, Ibrahim Habli, Garry Tew, Andrew Thompson
Peripheral Arterial Disease (PAD) is a chronic cardiovascular disease. It is highly prevalent in older adults. Mobile Health (mHealth) and Telehealth technologies are considered two central digital solutions for enabling patient-centred care. There is evidence that physical activity apps can improve health outcomes in adults. The aim of this project is to develop a prototype of smart phone app to target patients with PAD, which we named YORwalK, to promote exercise and track changes in walking ability in this population...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677007/near-continuous-glucose-monitoring-makes-glycemic-control-safer-in-icu-patients
#10
Jean-Charles Preiser, Olivier Lheureux, Aurelie Thooft, Serge Brimioulle, Jacques Goldstein, Jean-Louis Vincent
OBJECTIVES: Tight glycemic control using intermittent blood glucose measurements is associated with a risk of hypoglycemia. Glucose concentrations can now be measured near continuously (every 5-15 min). We assessed the quality and safety of glycemic control guided by a near-continuous glucose monitoring system in ICU patients. DESIGN: Prospective, cluster-randomized, crossover study. SETTING: Thirty-five-bed medico-surgical department of intensive care with four separate ICUs...
April 19, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29676627/effect-of-world-trade-center-dust-exposure-and-chronic-intermittent-hypoxia-on-macrophage-matrix-metalloproteinase-12-expression-in-mice
#11
Jared Radbel, Oanh Le-Hoang, Kinal N Vayas, Kaiwal Patel, Michael Goedken, Vasanthi R Sunil, Debra Laskin, Jag Sunderram
RATIONALE: The pathophysiologic mechanisms by which World Trade Center (WTC) dust exposure leads to pulmonary disease have not been established. Matrix metalloproteinase-12 (MMP-12) is involved in the development of pulmonary fibrosis and chronic obstructive pulmonary disease. We have previously shown that exposure of mice to WTC dust results in increased expression of matrix metalloproteinase 12 by alveolar macrophages. Matrix metalloproteinase 12 expression is regulated, in part, by oxidative stress, which is also increased after WTC dust exposure...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676198/blockade-of-at1-type-receptors-for-angiotensin-ii-prevents-cardiac-microvascular-fibrosis-induced-by-chronic-stress-in-sprague-dawley-rats
#12
Lília Taddeo Firoozmand, Andrea Sanches, Nilsa Regina Damaceno-Rodrigues, Juliana Dinéia Perez, Danielle Sanches Aragão, Rodolfo Mattar Rosa, Fernanda Klein Marcondes, Dulce Elena Casarini, Elia Garcia Caldini, Tatiana Sousa Cunha
To test the effects of chronic-stress on the cardiovascular system, the model of chronic mild unpredictable stress (CMS) has been widely used. The CMS protocol consists of the random, intermittent, and unpredictable exposure of laboratory animals to a variety of stressors, during 3 consecutive weeks. In this study, we tested the hypothesis that exposure to the CMS protocol leads to left ventricle microcirculatory remodeling that can be attenuated by angiotensin II receptor blockade. Male Sprague-Dawley rats were randomly assigned into four groups: Control, Stress, Control + losartan, and Stress + losartan (N = 6, each group, losartan: 20 mg/kg/day)...
April 20, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29675669/can-we-draw-general-conclusions-from-interval-training-studies
#13
Ricardo Borges Viana, Claudio Andre Barbosa de Lira, João Pedro Araújo Naves, Victor Silveira Coswig, Fabrício Boscolo Del Vecchio, Rodrigo Ramirez-Campillo, Carlos Alexandre Vieira, Paulo Gentil
Interval training (IT) has been used for many decades with the purpose of increasing performance and promoting health benefits while demanding a relatively small amount of time. IT can be defined as intermittent periods of intense exercise separated by periods of recovery and has been divided into high-intensity interval training (HIIT), sprint interval training (SIT), and repeated sprint training (RST). IT use has resulted in the publication of many studies and many of them with conflicting results and positions...
April 19, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29675635/intussusception-after-roux-en-y-gastric-bypass-laparoscopic-management
#14
Enrico Facchiano, Emanuele Soricelli, Luca Leuratti, Viviana Caputo, Giovanni Quartararo, Marcello Lucchese
INTRODUCTION: Intussusception represents an uncommon cause of intestinal obstruction after Rouxen-Y gastric bypass. Symptoms are not specific and clinical presentation may vary from acute intestinal obstruction with or without bowel necrosis to intermittent or chronic pain. CT scan is the diagnostic test of choice. MATERIALS AND METHODS: A 38-year-old woman who had undergone RYGBP 5 months prior was admitted to our Emergency Department with acute abdominal pain, alimentary and bilious vomiting, and fever...
April 19, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29675607/medical-and-financial-burden-of-acute-intermittent-porphyria
#15
Rochus A Neeleman, Margreet A E M Wagenmakers, Rita H Koole-Lesuis, G Sophie Mijnhout, J H Paul Wilson, Edith C H Friesema, Janneke G Langendonk
INTRODUCTION: A small proportion of patients with acute intermittent porphyria (AIP) suffer from recurrent porphyric attacks, with a severely diminished quality of life. In this retrospective case-control study, the burden of disease is quantified and compared among three AIP patient subgroups: cases with recurrent attacks, cases with one or occasional attacks and asymptomatic carriers. METHODS: Data from patient records and questionnaires were collected in patients between 1960 and 2016 at the Erasmus Medical Center, Rotterdam, the Netherlands...
April 19, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29675477/dextranomer-hyaluronic-acid-calcification-masquerading-as-distal-ureteral-calculi-in-a-patient-previously-treated-for-vesicoureteral-reflux
#16
Muammer Bozkurt, Samir Agalarov, Erkan Merder, Fatih Altunrende
Subureteral endoscopic injection is a safe and effective treatment for vesicoureteral reflux (VUR). Dextranomer/hyaluronic acid (Dx/HA) is the most commonly used bulking agent for the treatment of VUR. We report a confusing radiographic finding of calcified Dx/HA injection initially simulates distal ureteral stone in a female patient who has intermittent lumbar pain. Calcification of Dx/HA implants may mimic distal ureteral calculi; therefore, urologists should be aware of the potentially confusing radiographic images...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29675346/factors-affecting-surgical-outcome-of-intermittent-exotropia
#17
Chee-Ming Lee, Ming-Hui Sun, Ling-Yuh Kao, Ken-Kuo Lin, Meng-Ling Yang
PURPOSE: The purpose of this study was to investigate the factors affecting surgical outcome in intermittent exotropia. DESIGNS: This was a retrospective interventional study. METHODS: Intermittent exotropic patients who had undergone surgical correction with a postoperative follow-up period of 1 month or more were included in the study. Surgical success was defined as an alignment between 10 prism diopters (PD) of exotropia or 5 PD of esotropia at 1 month...
January 2018: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675186/extraction-of-nickel-from-nife-ldh-into-ni-2-p-nife-hydroxide-as-a-bifunctional-electrocatalyst-for-efficient-overall-water-splitting
#18
Fang-Shuai Zhang, Jia-Wei Wang, Jun Luo, Rui-Rui Liu, Zhi-Ming Zhang, Chun-Ting He, Tong-Bu Lu
The development of highly efficient, low-cost and stable electrocatalysts for overall water splitting is highly desirable for the storage of intermittent solar energy and wind energy sources. Herein, we show for the first time that nickel can be extracted from NiFe-layered double hydroxide (NiFe-LDH) to generate an Ni2 P@FePO x heterostructure. The Ni2 P@FePO x heterostructure was converted to an Ni2 P@NiFe hydroxide heterostructure (P-NiFe) during water splitting, which displays high electrocatalytic performance for both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in 1...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675134/leptin-and-leptin-resistance-in-the-pathogenesis-of-obstructive-sleep-apnea-a-possible-link-to-oxidative-stress-and-cardiovascular-complications
#19
REVIEW
Slava Berger, Vsevolod Y Polotsky
Obesity-related sleep breathing disorders such as obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) cause intermittent hypoxia (IH) during sleep, a powerful trigger of oxidative stress. Obesity also leads to dramatic increases in circulating levels of leptin, a hormone produced in adipose tissue. Leptin acts in the hypothalamus to suppress food intake and increase metabolic rate. However, obese individuals are resistant to metabolic effects of leptin. Leptin also activates the sympathetic nervous system without any evidence of resistance, possibly because these effects occur peripherally without a need to penetrate the blood-brain barrier...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29674494/safety-and-efficacy-of-vorinostat-bortezomib-doxorubicin-and-dexamethasone-in-a-phase-i-ii-study-for-relapsed-or-refractory-multiple-myeloma-verumm-study-vorinostat-in-elderly-relapsed-and-unfit-multiple-myeloma
#20
Johannes M Waldschmidt, Alexander Keller, Gabriele Ihorst, Olga Grishina, Stefan Müller, Dagmar Wider, Anna V Frey, Kristina King, Roman Simon, Annette May, Pierfrancesco Tassone, Justus Duyster, Manfred Jung, Noopur Raje, Ralph Wäsch, Monika Engelhardt
This phase I/II trial was conducted to investigate the safety, efficacy, and pharmacodynamics of the pan-HDAC-inhibitor (HDACi) vorinostat combined with bortezomib, doxorubicin, and dexamethasone (VBDD) in patients suffering from relapsed/refractory multiple myeloma (RRMM). In the phase I part of this study, 9/33 patients received dose-escalated vorinostat (100, 200, 300mg), using a 4-day-on and 4-day-off schedule, and a standard 3+3 design. In the phase II part of the study, 24/33 patients were included to further assess VBDD's safety and efficacy...
April 19, 2018: Haematologica
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