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Gauri V Deodhar, Marisa L Adams, Sutapa Joardar, Madhura Joglekar, Malcolm Davidson, Madelyn Mettler, Sydney A Toler, Fiona Davies, Brian G Trewyn
Mesoporous silica nanoparticles (MSN) with enlarged pores were prepared, characterized, and reversibly dissociated subunits of Concanavalin A were entrapped in the mesopores as shown by multiple biochemical and material characterizations. When loaded in the MSN, we demonstrated protein stability from proteases and, upon release, the subunits reassociated into active proteins shown through mannose binding. We have demonstrated a versatile and facile method to load multisubunit proteins into MSN with potential applications in enhancing the delivery of large therapeutic proteins...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Erika V Almeida, Samuel L De Brito
INTRODUCTION: Complexes of technetium-99m (99mTc) with meso-dimercaptosuccinic acid (DMSA) have been widely used as diagnostic agents in nuclear medicine. The degradation products (DP) of DMSA formed under different forced conditions have been identified through HPLC-DAD and LC-MSn studies. In this study, the DMSA kit was subjected to forced degradation under hydrolysis conditions as prescribed by the International Conference on Harmonization (ICH) guideline Q1A. METHODS: Chromatographic separation was accomplished on a reverse phase Shim-Pack VP-ODS (150 mm × 4...
November 10, 2017: Nuclear Medicine and Biology
Roudaina Benzekri, Lamjed Bouslama, Adele Papetti, Majdi Hammami, Abderrazak Smaoui, Ferid Limam
Genital herpes is a sexually transmitted disease caused by herpes simplex virus type 2 (HSV-2). Nucleoside analogues such as acyclovir (ACV) are the usual therapy for treating HSV infection. However, the overuse of this drug has led to the emergence of resistant strains. Therefore, the search for new alternative or complementary molecules to overcome this obstacle is needed. In this objective, Peganum harmala was investigated for its HSV-2 activity. The organic extracts of the different plant organs were evaluated for their cytotoxicity on Vero cells by the MTT test and anti HSV-2 activity by plaque reduction assay...
December 6, 2017: Microbial Pathogenesis
Ying Wang, Yu Cui, Yating Zhao, Qinfu Zhao, Bing He, Qiang Zhang, Siling Wang
The surface chemistry and size of nanoparticles can greatly impact their interaction with biological pathways and alter efficacy. However, the interplay between surface modification and particle size has not been well investigated especially for oral delivery. It is necessary to maximize the bioavailability of loading therapeutics. Here, we prepared different sized mesoporous silica nanoparticles (100-500 nm) and conjugated them with polyethylenimine-coated carbondots (PCD) for effective transepithelial absorption...
November 22, 2017: Journal of Colloid and Interface Science
Yongju He, Bowen Zeng, Shuquan Liang, Mengqiu Long, Hui Xu
Biodegradability is one of the most critical issues for silica-based nanodrug delivery systems, since it is crucial prerequisites for the successful translation in clinics. In this work, a novel mesoporous silica-calcium phosphate (MS-CAP) hybrid nanocarrier with a fast pH-responsive biodegradation rate was developed by a one-step method, where CAP precursors (Ca2+ and PO43-) were incorporated into silica matrix during the growth process. The morphology and structure of MS-CAP were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption-desorption isotherms, fourier transformed infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS)...
December 7, 2017: ACS Applied Materials & Interfaces
Lifeng Wang, Hao Yu, Yana Zhang, Caiyu Dong, Bo Liu
BACKGROUND: Despite its critical utility in providing life support to patients with impaired respiratory functions, prolonged mechanical ventilation has been found to cause a series of pathological changes in the lung that are collectively referred to as ventilator-induced lung injury (VILI). This study aims to investigate the therapeutic effects of mesoporous silica nanoparticles (DATS-MSN), which is capable of releasing H2S in a slow and controlled manner, on VILI. METHODS: A murine VILI model was generated...
December 5, 2017: Experimental Lung Research
Jeanne Moore, Petra Goodman, Janet Selway, Elizabeth Hawkins-Walsh, Janet Merritt, Jill Dombrowski
BACKGROUND: Substance use disorders are a major public health problem. As primary care providers, nurse practitioners (NPs) must be proficient at screening, identifying, and intervening for at-risk patients. Screening, brief intervention, and referral to treatment (SBIRT) is a well-established, evidence-based model for teaching behavioral health skills to health care providers. It is vital that Master of Science in Nursing (MSN)-NP programs incorporate SBIRT into their curricula. METHOD: SBIRT content was mapped to 10 courses across an MSN-NP program...
December 1, 2017: Journal of Nursing Education
Tavares Iasnaia Maria de Carvalho, Tuany Yuri Kuboyama Nogueira, Maria Aparecida Mauro, Sergio Gómez-Alonso, Eleni Gomes, Roberto Da-Silva, Isidro Hermosín-Gutiérrez, Ellen Silva Lago-Vanzela
Jambolan [Syzygium cumini (L.)] berries are a popular fruit in Brazil, renowned for their high phenolic compound (PC) content. These PCs have antioxidant, antibacterial, and other characteristics that may be beneficial to human health. The objective of the study was to evaluate the quantitative and qualitative changes of the main phenolic compounds (PCs) (anthocyanins, flavonols, and hydrolysable tannins) in the jambolan fruit, the produced fruit juice, and in the corresponding dehydrated powders obtained by foam mat drying (60, 70, and 80°C) and lyophilization (control)...
December 2017: Food Research International
M A Popot, M Jacobs, P Garcia, B Loup, D J Guyonnet, P L Toutain, L Bailly-Chouriberry, Y Bonnaire
BACKGROUND: Tiludronate is a bisphosphonate drug marketed to treat different bone conditions in horses. OBJECTIVES: The goal of this study was to measure the plasma concentrations of tiludronate in a population of race and sport horses under field conditions, and using pharmacokinetic population modeling, to estimate detection times for doping control. STUDY DESIGN: Prospective cohort. METHODS: This study was conducted under field conditions on 39 race or sport horses diagnosed with bone conditions based on a lameness examination and treated with tiludronate...
December 1, 2017: Equine Veterinary Journal
Si-Yi Liu, Hong-Zhu Zhang, Jing Fan, Zhan-Peng Shang, Fei Wang, Wei-Jie Li, Ying Liu, Jian-Qiu Lu, Jia-Yu Zhang
An effective method has been employed as a tool for screening active components in Kudiezi injection by using cell chromatography and sensitive UHPLC-HR-MSn method. The potential bioactive components in Kudiezi injection could be selectively bound to the HUVECs target cells first. After cell target desensitization and inactivation, the chemical constituents with cell target affinity were identified by LC-MS, so as to screen the possible active components in Kudiezi injection. Based on the accurate mass measurements and the retention time, in total, 9 compounds were tentatively identified and characterized, including 4 sesquiterpene lactones, 3 phenolic acids and 2 flavonoids...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Laura Mezquita, Melinda Charrier, Laura Faivre, Louise Dupraz, Béranger Lueza, Jordi Remon, David Planchard, Maria Virginia Bluthgen, Francesco Facchinetti, Arslane Rahal, Valentina Polo, Anas Gazzah, Caroline Caramella, Julien Adam, Jean Pierre Pignon, Jean-Charles Soria, Nathalie Chaput, Benjamin Besse
INTRODUCTION: The class I human leucocyte antigen (HLA) molecules play a critical role as an escape mechanism of antitumoral immunity. HLA-A2 status has been evaluated as a prognostic factor in lung cancer, mostly in localized disease and with inconsistent findings. We evaluated the role of HLA-A2 status as a prognostic factor in a large and homogeneus cohort of advanced NSCLC patients. METHODS: Advanced NSCLC patients eligible for platinum-based chemotherapy were consecutively included in a single center between October 2009 and July 2015 in the prospective MSN study (NCT02105168)...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Fan Yuan, Jiang-Lan Li, Han Cheng, Xuan Zeng, Xian-Zheng Zhang
In order to obtain an optimal therapeutic effect with minimal systemic toxicity, a redox-responsive mesoporous silica nanoparticle (MSN)-based platform modified with protoporphyrin IX (PpIX)-multifunctional peptides was synthesized as an intelligent theranostic agent carrier. This redox-responsive nanoplatform could release the theranostic agent under a glutathione stimulus, produce fluorescence recovery for tumor-specific fluorescence imaging and provide tumor-enhanced photodynamic therapy.
November 29, 2017: Biomaterials Science
Sheng-Xing Wang, Yu-Lei Zhu, De-Xin Zhang, Hui Shao, Peng Liu, Jian-Bang Hu, Heng Zhang, Hai-Ping Zhang, Cheng Chang, Jie Lu, Xian-Chun Xia, Gen-Lou Sun, Chuan-Xi Ma
Genetic improvement of grain yield is always an important objective in wheat breeding. Here, a genome-wide association study was conducted to parse the complex genetic composition of yield-related traits of 105 elite wheat varieties (lines) using the Wheat 90K Illumina iSelect SNP array. Nine yield-related traits, including maximum number of shoots per square meter (MSN), effective number of spikes per square meter (ESN), percentage of effective spike (PES), number of kernels per spike (KPS), thousand-kernel weight (TKW), the ratio of kernel length/kernel width (RLW), leaf-area index (LAI), plant height (PH), and grain yield (GY), were evaluated across four environments...
2017: PloS One
Lijuan Hou, Wei Chen, Xiaoli Liu, Decai Qiao, Fu-Ming Zhou
Epidemiological studies indicate that physical activity and exercise may reduce the risk of developing Parkinson's disease (PD), and clinical observations suggest that physical exercise can reduce the motor symptoms in PD patients. In experimental animals, a profound observation is that exercise of appropriate timing, duration, and intensity can reduce toxin-induced lesion of the nigrostriatal dopamine (DA) system in animal PD models, although negative results have also been reported, potentially due to inappropriate timing and intensity of the exercise regimen...
2017: Frontiers in Aging Neuroscience
Henrika Wickström, Ellen Hilgert, Johan O Nyman, Diti Desai, Didem Şen Karaman, Thomas de Beer, Niklas Sandler, Jessica M Rosenholm
Mesoporous silica nanoparticles (MSNs) have shown great potential in improving drug delivery of poorly water soluble (BCS class II, IV) and poorly permeable (BCS class III, IV) drugs, as well as facilitating successful delivery of unstable compounds. The nanoparticle technology would allow improved treatment by reducing adverse reactions of currently approved drugs and possibly reintroducing previously discarded compounds from the drug development pipeline. This study aims to highlight important aspects in mesoporous silica nanoparticle (MSN) ink formulation development for digital inkjet printing technology and to advice on choosing a method (2D/3D) for nanoparticle print deposit characterization...
November 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Borhane E C Ziani, Lillian Barros, Ali Z Boumehira, Khaldoun Bachari, Sandrina A Heleno, Maria Jose Alves, Isabel C F R Ferreira
The infusions of Thymus pallescens Noë, Saccocalyx satureioides Coss. et Dur., Ptychotis verticillata Briq. and Limoniastrum guyonianum Boiss. have been used as medicinal remedies for many diseases in Algerian folk medicine. These species have also been well documented as rich sources of phytochemicals, such as phenolic compounds with wide diversified chemical structures, which exhibit far-ranging biological activities. Thus, the phenolic compound profile of the aqueous extracts, obtained by infusing, of the mentioned species was obtained by HPLC-DAD-ESI/MS, and their antibacterial activity was evaluated against clinical isolates...
November 20, 2017: Food & Function
Feng Yu, Huijing Wu, Yao Tang, Yufang Xu, Xuhong Qian, Weiping Zhu
In this study, a temperature and ROS-responsive drug delivery system ROSP@MSN based on mesoporous silica nanoparticles has been designed and synthesized by taking advantage of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate modified polymers (ROSP) as "nano-valve", which can respond selectively to cancer exclusive microenvironment and implement targeted drug release. Due to the superior temperature-sensitive properties of ROSP, ROSP@MSN could achieve cargo loading in cold water, and subsequently close the pore by raising temperature to obtain ROSP@MSN@DOX...
November 13, 2017: International Journal of Pharmaceutics
Zhonghui Chen, Mi Sun, Fang Luo, Kefeng Xu, Zhenyu Lin, Lan Zhang
In most aptamer based stimulus response mesoporous silica nanoparticles (MSN) systems, the aptamer is modified on the MSN via electrostatic interaction, however leakage might exist after a certain time in the system and hence the stability is not good. In this study, the pores of MSN were capped by aptamer through click chemistry reaction for the first time and the system was then employed to develop a fluorescence biosensor. Specifically, the aptamer of the target (thrombin in this study) was hybridized with its complementary DNA (which was initially modified with alkyne at the terminal) to form a double strand DNA (dsDNA) firstly, and then this dsDNA was modified on N3 modified MSN via Cu(I) catalyzed alkyne-azide cycloaddition reaction...
February 1, 2018: Talanta
Angel A Robles G, Ana V Vega, Carolina Gonzalez-Sandoval, Jaime Barral
Potassium channels play an important role in modulating synaptic activity both at presynaptic and postsynaptic levels. We have shown before that presynaptically located KV and KIR channels modulate the strength of corticostriatal synapses in rat brain, but the role of other types of potassium channels at these synapses remains largely unknown. Here we show that calcium-dependent potassium channels BK-type but not SK-type channels are located presynaptically in corticostriatal synapses. We stimulated cortical neurons in rat brain slices and recorded postsynaptic excitatory potentials (EPSP) in medium spiny neurons (MSN) in dorsal neostriatum...
November 14, 2017: Synapse
Bangda Wang, Yuexi Zhou, Lei Li, Hui Xu, Yinglong Sun, Yi Wang
Trace amounts of toxic metals are usually difficult to be purified by conventional chemical precipitation or physical adsorption in wastewater. In this study, in order to realize high-value utilization of coal fly ash for wastewater purification, a novel method was applied to prepare high-performance mesoporous silica materials from coal fly ash. In comparison with a commonly used method, characterizations revealed that the new method obtained mesoporous silica nanospheres with uniformly distributed cyano groups (denoted by MSN), while the common method only obtained irregular sponge-like microstructure (denoted by ISM)...
November 1, 2017: Journal of Hazardous Materials
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