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https://www.readbyqxmd.com/read/28544466/simultaneous-imaging-of-endogenous-survivin-mrna-and-on-demand-drug-release-in-live-cells-by-using-a-mesoporous-silica-nanoquencher
#1
Peiyan Yuan, Xin Mao, Kok Chan Chong, Jiaqi Fu, Sijun Pan, Shuizhu Wu, Changmin Yu, Shao Q Yao
The design of multifunctional drug delivery systems capable of simultaneous target detection, imaging, and therapeutics in live mammalian cells is critical for biomedical research. In this study, by using mesoporous silica nanoparticles (MSNs) chemically modified with a small-molecule dark quencher, followed by sequential drug encapsulation, MSN capping with a dye-labeled antisense oligonucleotide, and bioorthogonal surface modification with cell-penetrating poly(disulfide)s, the authors have successfully developed the first mesoporous silica nanoquencher (qMSN), characterized by high drug-loading and endocytosis-independent cell uptake, which is able to quantitatively image endogenous survivin mRNA and release the loaded drug in a manner that depends on the survivin expression level in tumor cells...
May 24, 2017: Small
https://www.readbyqxmd.com/read/28538460/transforming-care-for-victims-of-violence
#2
Anne C Boatright
In this month's Magnet® Perspectives column, Anne Boatright, MSN, RN, SANE, describes her efforts to develop a comprehensive forensic nursing program at Methodist Hospital in Omaha. Ms Boatright transformed a sexual assault nurse examiner (SANE) program into one that provides 24/7 coverage at Methodist's 2 SANE locations and cares not only for victims of sexual assault but also for the victims domestic violence, sex trafficking, strangulation, elder abuse, and neglect. Her work extends beyond the walls of Methodist to the community, where she serves as a core member of the Nebraska Human Trafficking Task Force...
June 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28536970/mesoporous-silica-nanoparticle-coated-microneedle-arrays-for-intradermal-antigen-delivery
#3
Jing Tu, Guangsheng Du, M Reza Nejadnik, Juha Mönkäre, Koen van der Maaden, Paul H H Bomans, Nico A J M Sommerdijk, Bram Slütter, Wim Jiskoot, Joke A Bouwstra, Alexander Kros
PURPOSE: To develop a new intradermal antigen delivery system by coating microneedle arrays with lipid bilayer-coated, antigen-loaded mesoporous silica nanoparticles (LB-MSN-OVA). METHODS: Synthesis of MSNs with 10-nm pores was performed and the nanoparticles were loaded with the model antigen ovalbumin (OVA), and coated with a lipid bilayer (LB-MSN-OVA). The uptake of LB-MSN-OVA by bone marrow-derived dendritic cells (BDMCs) was studied by flow cytometry. The designed LB-MSN-OVA were coated onto pH-sensitive pyridine-modified microneedle arrays and the delivery of LB-MSN-OVA into ex vivo human skin was studied...
May 23, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28534652/a-review-of-the-evidence-of-zolpidem-efficacy-in-neurological-disability-after-brain-damage-due-to-stroke-trauma-and-hypoxia-a-justification-of-further-clinical-trials
#4
J A Sutton, R P Clauss
During 15 years, 23 clinical reports and 6 studies have demonstrated associations between sub-sedative doses of zolpidem and recoveries from brain damage due to strokes, trauma and hypoxia. Clinical findings include unexpected awakenings from vegetative states and regressions of stroke symptoms after dosing that disappear during elimination and reappear on repeat dosing. Initially single-photon emission computed tomography scans showed improved perfusion within, around and distant from infarctions. Then positron emission tomography scans and electroencephalography detected renewed metabolic and neuronal activity...
May 23, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28533681/synergistic-bactericidal-activity-of-chlorhexidine-loaded-silver-decorated-mesoporous-silica-nanoparticles
#5
Meng-Meng Lu, Qiu-Jing Wang, Zhi-Min Chang, Zheng Wang, Xiao Zheng, Dan Shao, Wen-Fei Dong, Yan-Min Zhou
Combination of chlorhexidine (CHX) and silver ions could engender synergistic bactericidal effect and improve the bactericidal efficacy. It is highly desired to develop an efficient carrier for the antiseptics codelivery targeting infection foci with acidic microenvironment. In this work, monodisperse mesoporous silica nanoparticle (MSN) nanospheres were successfully developed as an ideal carrier for CHX and nanosilver codelivery through a facile and environmentally friendly method. The CHX-loaded, silver-decorated mesoporous silica nanoparticles (Ag-MSNs@CHX) exhibited a pH-responsive release manner of CHX and silver ions simultaneously, leading to synergistically antibacterial effect against both gram-positive Staphylococcus aureus and gram-negative Escherichia coli...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28531297/mechanisms-of-kappa-opioid-receptor-potentiation-of-dopamine-d2-receptor-function-in-quinpirole-induced-locomotor-sensitization-in-rats
#6
Angélica P Escobar, Marcela P González, Rodrigo C Meza, Verónica Noches, Pablo Henny, Katia Gysling, Rodrigo A España, José A Fuentealba, María E Andrés
Background: Increased locomotor activity in response to the same stimulus is an index of behavioral sensitization observed in preclinical models of drug addiction and compulsive behaviors. Repeated administration of Quinpirole (QNP), a D2/D3 dopamine agonist, induces locomotor sensitization. This effect is potentiated and accelerated by co-administration of U69593, a kappa opioid receptor agonist (KOR). The mechanism underlying KOR potentiation of QNP-induced locomotor sensitization remains to be elucidated...
May 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28530792/phosphonated-pillar-5-arene-valved-mesoporous-silica-drug-deliv-ery-systems
#7
Xuan Huang, Shanshan Wu, Xiaokang Ke, Xueyuan Li, Xuezhong Du
To explore the diversity and promising applications of pillararene-based molecular machines, phosphonated pillar[5]arenes (PPA[5]) were synthesized to construct novel supramolecular nanovalves for the first time, based on mesoporous silica nanoparticles (MSNs) functionalized with choline and pyridinium moieties, respectively. PPA[5] encircled the choline or pyridinium stalks to construct supramolecular nanovalves for encapsulation of drugs within the MSN pores. PPA[5] showed a high binding affinity for the quaternary ammonium stalks through the host-guest interactions primarily via ion pairing between the phosphonate and quaternary ammonium moieties, in comparison to carboxylated pillar[5]arene (CPA[5]), to minimize premature drug release...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28529643/mir-200c-inhibits-the-tumor-progression-of-glioma-via-targeting-moesin
#8
Yuanyuan Qin, Weilong Chen, Bingjie Liu, Lei Zhou, Lu Deng, Wanxiang Niu, Dejun Bao, Chuandong Cheng, Dongxue Li, Suling Liu, Chaoshi Niu
We attempt to demonstrate the regulatory role of miR-200c in glioma progression and its mechanisms behind. Here, we show that miR-200c expression was significantly reduced in the glioma tissues compared to paratumor tissues, especially in malignant glioma. Exogenous overexpression of miR-200c inhibited the proliferation and invasion of glioma cells. In addition, the in vivo mouse xenograft model showed that miR-200c inhibited glioma growth and liver metastasis, which is mainly regulated by targeting moesin (MSN)...
2017: Theranostics
https://www.readbyqxmd.com/read/28522938/mucin-1-antibody-conjugated-mesoporous-silica-nanoparticles-for-selective-breast-cancer-detection-in-a-mucin-1-transgenic-murine-mouse-model
#9
Didier Dréau, Laura Jeffords Moore, Merlis P Alvarez-Berrios, Mubin Tarannum, Pinku Mukherjee, Juan L Vivero-Escoto
Mucin-1 (MUC1), a transmembrane glycoprotein is aberrantly expressed on ~90% of breast cancer and is an excellent target for nanoparticulate targeted imaging. In this study, the development of a dye-doped NIR emitting mesoporous silica nanoparticles platform conjugated to tumor-specific MUC1 antibody (ab-tMUC1-NIR-MSN) for in vivo optical detection of breast adenocarcinoma tissue is reported. The structural properties, the in vitro and in vivo performance of this nanoparticle-based probe were evaluated. In vitro studies showed that the MSN-based optical imaging nanoprobe is non-cytotoxic and targets efficiently mammary cancer cells overexpressing human tMUC1 protein...
December 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/28511394/breast-biomarkers-comparison-on-whole-section-and-tissue-microarray-section
#10
Sneha S Chavan, Savithri Ravindra, Msn Prasad
INTRODUCTION: Estrogen Receptor (ER), Progesterone Receptor (PR) and Her2/neu are routinely studied markers for breast carcinoma. Analysis of these biomarkers is traditionally done by Immunohistochemistry (IHC) on whole sections. These markers can also be studied on Tissue Microarray (TMA) sections. Tissue microarray is a technique where core samples from different paraffin blocks are arrayed on a single recipient block which can then be cut to yield a single section with multiple cores in it...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28507435/mesoporous-silica-nanoparticles-trigger-mitophagy-in-endothelial-cells-and-perturb-neuronal-network-activity-in-a-size-and-time-dependent-manner
#11
Antonina Orlando, Emanuela Cazzaniga, Maria Tringali, Francesca Gullo, Andrea Becchetti, Stefania Minniti, Francesca Taraballi, Ennio Tasciotti, Francesca Re
PURPOSE: Mesoporous silica nanoparticles (MSNPs) are excellent candidates for biomedical applications and drug delivery to different human body areas, the brain included. Although toxicity at cellular level has been investigated, we are still far from using MSNPs in the clinic, because the mechanisms involved in the cellular responses activated by MSNPs have not yet been elucidated. MATERIALS AND METHODS: This study used an in vitro multiparametric approach to clarify relationships among size, dose, and time of exposure of MSNPs (0...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28506802/stealth-magnetic-nanocarriers-of-sirna-as-platform-for-breast-cancer-theranostics
#12
J Bruniaux, S Ben Djemaa, K Hervé-Aubert, H Marchais, I Chourpa, S David
The endogenous mechanism of RNA interference is more and more used in research to obtain specific down-regulation of gene expression in diseases such as breast cancer. Currently, despite the new fields of study open up by RNA interference, the rapid degradation of siRNA by nucleases and their negative charges prevent them from crossing cell membranes. To overcome these limitations, superparamagnetic iron oxide nanoparticles (SPIONs) represent a promising alternative for nucleic acid delivery. Previously, we reported the magnetic siRNA nanovectors (MSN) formulation using electrostatic assembly of (1) SPIONs, also able to act as contrast agents for magnetic resonance imaging (MRI), (2) siRNA and (3) chitosan aiming at their protection and enhancing their transfection efficacy...
May 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28506197/high-resolution-mass-spectrometry-confirms-the-presence-of-a-hydroxyproline-hyp-post-translational-modification-in-the-ggggp-linker-of-an-fc-fusion-protein
#13
Chris Spahr, Gunasekaran Kannan, Kenneth W Walker, Stone D-H Shi
Flexible and protease resistant (G4S)n linkers are used extensively in protein engineering to connect various protein domains. Recently, a number of groups have observed xylose-based O-glycosylation at linker Ser residues that yield unwanted heterogeneity and may affect product quality. Because of this, an engineering effort was implemented to explore different linker sequence constructs. Here, we demonstrate the presence of an unexpected hydroxylation of a prolyl residue in the linker, made possible through the use of high-resolution mass spectrometry (HR-MS) and MSn...
May 16, 2017: MAbs
https://www.readbyqxmd.com/read/28499164/mechanical-properties-and-antibiotic-release-characteristics-of-poly-methyl-methacrylate-based-bone-cement-formulated-with-mesoporous-silica-nanoparticles
#14
Kumaran Letchmanan, Shou-Cang Shen, Wai Kiong Ng, Poddar Kingshuk, Zhilong Shi, Wilson Wang, Reginald B H Tan
The influence of mesoporous silica nanoparticles (MSNs) loaded with antibiotics on the mechanical properties of functional poly(methyl methacrylate)-(PMMA) based bone cements is investigated. The incorporation of MSNs to the bone cements (8.15wt%) shows no detrimental effects on the biomechanical properties of the freshly solidified bone cements. Importantly, there are no significant changes in the compression strength and bending modulus up to 6 months of aging in PBS buffer solution. The preserved mechanical properties of MSN-functionalized bone cements is attributed to the unchanged microstructures of the cements, as more than 96% of MSNs remains in the bone cement matrix to support the cement structures after 6 months of aging...
May 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28498352/encapsulation-of-16-hydroxycleroda-3-13-dine-16-15-olide-in-mesoporous-silica-nanoparticles-as-a-natural-dipeptidyl-peptidase-4-inhibitor-potentiated-hypoglycemia-in-diabetic-mice
#15
Po-Kai Huang, Shi-Xiang Lin, May-Jywan Tsai, Max K Leong, Shian-Ren Lin, Ranjith Kumar Kankala, Chia-Hung Lee, Ching-Feng Weng
Natural supplements comprise good efficacy with less adverse effects as against diabetic therapy, but their advancement as anti-diabetic agents is unsatisfactory with regard to the delivery system. Dipeptidyl peptidase-4 (DPP4)/CD26) can degrade glucagon-like pepetide-1 (GLP-1) which renders a decrease of blood glucose levels. 16-hydroxycleroda-3,13-dine-16,15-olide (HCD) extracted from Polyalthia longifolia, exhibits numerous medicinal potentials including hypoglycemic potential. On consideration of HCD application, the bioavailability is affected by low solubility...
May 12, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28496926/novel-ventricular-repolarization-indices-in-patients-with-coronary-slow-flow
#16
Murat Sucu, Berzal Ucaman, Orhan Ozer, Yakup Altas, Esra Polat
Background: Coronary slow flow (CSF) phenomenon is described angiographically as delayed progression of the injected contrast agents through the coronary arteries. Aim of this study was to analyze ventricular repolarization in CSF patients by using Tpeak-Tend interval, Tpeak-Tend/QT ratio, Tpeak-Tend/QTc ratio and other repolarization parameters since these parameters are used as predictors for ventricular arrhythmogenesis. Materials and Methods: We have retrospectively analyzed diagnostic coronary angiography results of 160 patients between 2010 and 2014...
October 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/28492505/mesoporous-silica-nanoparticles-as-carriers-for-intracellular-delivery-of-nucleic-acids-and-subsequent-therapeutic-applications
#17
REVIEW
Wenzhang Cha, Rengen Fan, Yufeng Miao, Yong Zhou, Chenglin Qin, Xiangxiang Shan, Xinqiang Wan, Jinbo Li
Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and antisense oligonucleotide (ASO), are powerful gene regulators, which have been demonstrated as promising drug candidates for therapeutic treatments. Nevertheless, poor cellular membrane permeability and serum stability have greatly hindered the applications of nucleic acids in biomedicine. To address these issues, associate carriers that can encapsulate and protect nucleic acids are urgently required. Mesoporous silica nanoparticles (MSNs or MSNPs), which are nanomaterials with excellent biocompatibility, large surface area for functionalization, and tunable pore size for encapsulating different cargos, are emerging as novel and ideal biomaterials for different biomedical applications...
May 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28488564/hippocampal-cholinergic-neurostimulating-peptide-as-a-possible-modulating-factor-against-glutamatergic-neuronal-disability-by-amyloid-oligomers
#18
Toyohiro Sato, Yoshiaki Ohi, Daisuke Kato, Masayuki Mizuno, Hiroshi Takase, Tetsuko Kanamori, Cesar V Borlongan, Akira Haji, Noriyuki Matsukawa
Despite having pathological changes in the brain associated Alzheimer's disease (AD), some patients have preserved cognitive function. A recent epidemiological study has shown that diet, exercise, cognitive training, and vascular risk monitoring interventions may reduce cognitive decline in at-risk elderly people in the general population. However, the details of molecular mechanisms underlying this cognitive function preservation are still unknown. Previous report demonstrated that enriched environments prevent the impairment of hippocampal long-term potentiation (LTP) through β2-adrenergic signals, when LTP is incompletely suppressed by synthetic amyloid-β (Aβ) oligomers...
May 9, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28482574/epcam-antibody-conjugated-mesoporous-silica-nanoparticles-to-enhance-the-anticancer-efficacy-of-carboplatin-in-retinoblastoma
#19
Wei Qu, Bo Meng, Yangyang Yu, Shaowei Wang
Retinoblastoma (RB) is a rare type of tumor which occurs in the intraocular spaces of eye. Carboplatin (CRB) has been used for the treatment of RB along with focal therapy. In this study, we have demonstrated the preparation of EpCAM-conjugated mesoporous silica nanoparticles for the successful delivery of carboplatin (CRB) to the retinoblastoma cells. The particles size and morphology was nanosized and spherical and exhibited a controlled release kinetics. Cellular uptake studies reveal that enhanced internalization was observed for EpCMSN compared to that of CMSN...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482558/cellular-level-evaluation-and-lysozyme-adsorption-regulation-of-bimodal-nanoporous-silica
#20
Jing Li, Na Fan, Xin Wang, Zhonggui He
The present work initially evaluated cellular toxicity and uptake of our previous biomimetic bimodal nanoporous silica (B-BNS) and applied it as lysozyme adsorbent, which aimed to study potential ability of B-BNS as antitumor biological macromolecules carrier. To highlight the advantage of bimodal mesopores, comparisons were made between single mesoporous silica nanoparticles (S-MSN) and B-BNS. Cell evaluation work was conducted using MCF-7 cells and lysozyme adsorption process was studied with pH and lysozyme concentration as independent variables...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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