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Juan Yue, Shi-Zhong Luo, Meng-Meng Lu, Dan Shao, Zheng Wang, Wen-Fei Dong
Mesoporous silica nanoparticles (MSNs) are promising drug carriers for use in cancer treatment owing to their excellent biocompatibility and drug loading capacity. However, MSN's incomplete drug release and toxic bioaccumulation phenomena limit their clinical application. Recently, researchers have presented redox responsive mesoporous organosilica nanoparticles containing disulfide (S-S) bridges (ss-MONs). These nanoparticles retained their ability to undergo structural degradation, and increased their local release activity when exposed to reducing agents...
April 19, 2018: Chemical Biology & Drug Design
Yan-Li Chang, Meng Shen, Xue-Yang Ren, Ting He, Le Wang, Shu-Sheng Fan, Xiu-Huan Wang, Xiao Li, Xiao-Ping Wang, Xiao-Yi Chen, Hong Sui, Gai-Mei She
Thymus quinquecostatus Celak is a species of thyme in China and it used as condiment and herbal medicine for a long time. To set up the quality evaluation of T. quinquecostatus , the response surface methodology (RSM) based on its 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity was introduced to optimize the extraction condition, and the main indicator components were found through an UPLC-LTQ-Orbitrap MSn method. The ethanol concentration, solid-liquid ratio, and extraction time on optimum conditions were 42...
April 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Kai Sun, Chaoqun You, Senlin Wang, Zhiguo Gao, Hongshuai Wu, W Andy Tao, Xiaoli Zhu, Baiwang Sun
A novel core-shell type nanoparticle (CSNP) was designed here to target co-delivery of doxorubicin (DOX) and photosensitizer indocyanine green (ICG) to tumor sites by the aid of NIR induced photothermal conversion effect for the purpose of synergistic chemo-photothermal cancer therapy. The electrostatically self-assembled CSNPs were prepared by amino-functionalized mesoporous silica nanoparticles (MSN-NH2) as the positive inner core and DSPE-PEG2000-COOH and DSPE-PEG2000-FA modified lecithin as the negative outer shell...
April 19, 2018: Nanotechnology
Sophia A Shahin, Ruining Wang, Shirleen I Simargi, Altagracia Contreras, Liliana Parra, Louise Qu, Wei Wen, Thanh Dellinger, Juli Unternaehrer, Fuyuhiko Tamanoi, Jeffrey I Zink, Carlotta A Glackin
TWIST protein is critical to development and is activated in many cancers. TWIST regulates epithelial-mesenchymal transition, and is linked to angiogenesis, metastasis, cancer stem cell phenotype, and drug resistance. The majority of epithelial ovarian cancer (EOC) patients with metastatic disease respond well to first-line chemotherapy but most relapse with disease that is both metastatic and drug resistant, leading to a five-year survival rate under 20%. We are investigating the role of TWIST in mediating these relapses...
April 14, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Simona Mancini, Luca Nardo, Maria Gregori, Inês Ribeiro, Francesco Mantegazza, Cristina Delerue-Matos, Massimo Masserini, Clara Grosso
BACKGROUND: Multi-target drugs have gained significant recognition for the treatment of multifactorial diseases such as depression. Under a screening study of multi-potent medicinal plants with claimed antidepressant-like activity, the phenolic-rich Annona muricata aqueous extract (AE) emerged as a moderate monoamine oxidase A (hMAO-A) inhibitor and a strong hydrogen peroxide (H2 O2 ) scavenger. PURPOSE: In order to protect this extract from gastrointestinal biotransformation and to improve its permeability across the blood-brain barrier (BBB), four phospholipid nanoformulations of liposomes and phytosomes functionalized with a peptide ligand promoting BBB crossing were produced...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Irena J Tatosian, Anna C Iacovino, Michael J Van Stipdonk
RATIONALE: In a previous study [Rapid Commun. Mass Spectrom. 2004; 18: 3028-3034], CID of [UVI O2 (ClO4 )]+ appeared to be influenced by the high levels of background H2 O in a quadrupole ion trap. The CID of the same species was re-examined here with the goal of determining whether additional, previously obscured dissociation pathways would be revealed under conditions in which the level of background H2 O was lower. METHODS: Water- and methanol-coordinated [UVI O2 (ClO4 )]+ precursor ions were generated by electrospray ionization...
April 12, 2018: Rapid Communications in Mass Spectrometry: RCM
Maroof M Adil, Thomas Gaj, Antara T Rao, Rishikesh U Kulkarni, Christina M Fuentes, Gokul N Ramadoss, Freja K Ekman, Evan W Miller, David V Schaffer
Huntington disease (HD) is an inherited, progressive neurological disorder characterized by degenerating striatal medium spiny neurons (MSNs). One promising approach for treating HD is cell replacement therapy, where lost cells are replaced by MSN progenitors derived from human pluripotent stem cells (hPSCs). While there has been remarkable progress in generating hPSC-derived MSNs, current production methods rely on two-dimensional culture systems that can include poorly defined components, limit scalability, and yield differing preclinical results...
April 3, 2018: Stem Cell Reports
William J Griffiths, Ian Gilmore, Eylan Yutuc, Jonas Abdel-Khalik, Peter J Crick, Thomas Hearn, Alison Dickson, Brian W Bigger, Teresa Hoi-Yee Wu, Anu Goenka, Arunabha Ghosh, Simon A Jones, Yuqin Wang
7-Oxocholesterol (7-OC), 5,6-epoxycholesterol (5,6-EC) and its hydrolysis product cholestane-3β,5α,6β-triol (3β,5α,6β-triol) are normally minor oxysterols in human samples, however, in disease their levels may be greatly elevated. This is the case in plasma from patients suffering from some lysosomal storage disorders e.g. Niemann Pick disease type C, or the inborn errors of sterol metabolism e.g. Smith-Lemli-Opitz syndrome and cerebrotendinous xanthomatosis. A complication in the analysis of 7-OC and 5,6-EC is that they can also be formed ex vivo from cholesterol during sample handling in air causing confusion with molecules formed in vivo...
April 6, 2018: Journal of Lipid Research
Dian Shi, Joshua W H Chang, Jaimin Choi, Bronwen Connor, Simon O'Carroll, Louise F B Nicholson, Joo Hyun Kim
Receptor for advanced glycation end products (RAGE) is a multi-ligand receptor involved in the pathology of several progressive neurodegenerative disorders including Huntington's disease (HD). We previously showed that the expression of RAGE and its colocalization with ligands were increased in the striatum of HD patients, increasing with grade severity, and that the pattern of RAGE expression coincided with the medio-lateral pattern of neurodegeneration. However, the exact role of RAGE in HD remains elusive...
April 3, 2018: Neuroscience
(no author information available yet)
Aponte, J. (2017): Acknowledgment of Reviewers. Hispanic Health Care International, 15, 200. Doi: 10.1177/1540415317746248 In the above "Acknowledgement of Reviewers", published in issue 15(4), nine reviewer names were not listed in the 'Acknowledgement to Reviewers' section. Please find below the names of the additional nine reviewers for 2017. The editor would also like to thank these reviewers for their participation and service to Hispanic Health Care International in 2017. María Luisa F. Arias, PhD, RN John Cowden, MD, MPH Giovanna De Oliveira, PhD, MSN, ARNP, ANP-C, PMHNP-BC Esther C...
March 2018: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
Jae-Hyun Jung, Dong-Hyun Kim, Kyung-Hyeon Yoo, Seog-Young Yoon, Yeon Kim, Moon-Kyoung Bae, Jin Chung, Ching-Chang Ko, Yong Hoon Kwon, Yong-Il Kim
OBJECTIVES: To synthesize a silver-doped bioactive glass/mesoporous silica nanoparticle (Ag-BGN@MSN), as well as to investigate its effects on dentinal tubule occlusion, microtensile bond strength (MTBS), and antibacterial activity. MATERIALS AND METHODS: Ag-BGN@MSN was synthesized using a modified "quick alkali-mediated sol-gel" method. Demineralized tooth disc models were made and divided into four groups; the following treatments were then applied: group 1-no treatment, group 2-bioglass, group 3-MSN, group 4-Ag-BGN@MSN...
April 6, 2018: Clinical Oral Investigations
Ru Feng, Zhen-Xiong Zhao, Shu-Rong Ma, Fang Guo, Yan Wang, Jian-Dong Jiang
Berberine (BBR) is considered a multi-target drug that has significant advantages. In contrast to its significant pharmacological effects in clinic, the plasma level of BBR is very low. Our previous work revealed that dihydroberberine (dhBBR) could be an absorbable form of BBR in the intestine, and butyrate is an active metabolite that is generated by gut bacteria in rats. In this study, for the first time we describe gut microbiota-regulated pharmacokinetics in beagle dogs after oral administration of BBR by single (50 mg/kg) or multiple doses (50 mg/kg/d) for 7 days...
2018: Frontiers in Pharmacology
Li-Hua Dong, Yan-Hui Kuang, Dong-Dong Fan, Tong Jiang, Liang-Mian Chen, Dong Zhang, Jing-Jing Zhu, Zhi-Min Wang, De-Qin Wang, Chu-Yuan Li
To investigate the differences of chemical compositions in Gynostemma pentaphyllum leaves prepared by different processing methods. Ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) was used to compare the chemical compositions between shade-dried processing and drum-dried processing. Forty six gypenosides were identified by control comparison, liquid chromatography-mass spectrometry(LC-MSn) fragmentation information, and literature data. The mass spectral peak area statistics was combined with principal component analysis(PCA), and the results showed that eight batches of Gynostemma pentaphyllum leaves samples were divided into two groups according to the two different processing methods; ten chemical compositions with significant differences were screened according to mass spectrum information combined with partial least-squares discriminant analysis(PLS-DA)...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Peng Pei, Fan Yang, Jiaxing Liu, Haoran Hu, Xiaoyu Du, Nobutaka Hanagata, Shichang Zhao, Yufang Zhu
A combination of chemotherapy and photothermal therapy (PTT) has emerged as a promising strategy for cancer therapy. To ensure that the chemotherapeutic drug and photothermal agent can be simultaneously delivered to the tumor site to exert their synergistic effects, a safe and efficient delivery system is needed. Herein, we fabricated doxorubicin hydrochloride (DOX)- and indocyanine green (ICG)-loaded microneedle (MN) patches (PVP@DOX/MSN@ICG) using a two-step casting process. Mesoporous silica nanoparticles (MSNs) were used to improve the ICG stability and avoid reducing its PTT efficiency in vivo...
March 29, 2018: Biomaterials Science
Yu Xu, Dandan Wang, Bingqi Zhu, Lan Tang, Jian Wang
As requested by regulatory authorities, polymerized impurities are an important issue of quality control. In this study, we presented the utilization of a trap-free two-dimensional chromatography, which was consisted by a high performance size exclusion chromatography (HPSEC) and a reversed-phase liquid chromatography (RP-LC) coupled to ion trap time-of-flight mass spectrometry with positive mode of electrospray ionization, to separate and characterize ten allergenic impurities in ceftazidime for injection, cefazolin sodium for injection, cefoperazone sodium and sulbactam sodium for injection and cefamandole nafate for injection...
March 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
Peter Lorenz, Annerose Heller, Marek Bunse, Miriam Heinrich, Melanie Berger, Jürgen Conrad, Florian C Stintzing, Dietmar R Kammerer
Seeds from Hypericum species have recently been identified as an interesting source of xanthone derivatives. Extraction of seeds from H. perforatum with MeOH and subsequent concentration via polyamide adsorption yielded a fraction enriched in tetrahydroxyxanthones (THX), which were further semipurified by silica chromatography. Based on tentative structure assignment of the two main THX X1 and X2 by NMR a total synthesis was performed for both compounds (THX 1 and 2, respectively), starting with an Ullmann ether synthesis...
March 25, 2018: Chemistry & Biodiversity
Li Zhang, Ho Pan Bei, Yun Piao, Yufeng Wang, Mo Yang, Xin Zhao
Mesoporous silica nanoparticles (MSNs) have been demonstrated to be one of the most promising drug delivery systems (DDSs) to transport a variety of drug/biomolecules. Functionalization of MSN surfaces with responsive polymer brushes endows them with intelligent and controllable drug delivery properties, i.e., the encapsulated drugs/biomolecules will only be released upon certain stimuli including pH, temperature variation, light irradiation, enzyme, ultrasound, or redox potential, thus maximizing their therapeutic efficiency and minimizing side effects...
March 24, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Carmen Jarne, María Savirón, María Pilar Lapieza, Luis Membrado, Jesús Orduna, Javier Galbán, Rosa Garriga, Gertrud Elisabeth Morlock, Vicente Luis Cebolla
High-performance thin-layer chromatography was directly combined with electrospray mass spectrometry (ESI-MS)for structural identification issues below the level of lipid classes in complex samples through a portable, automated, elution-based interface. For samples as diverse as biodiesel and human plasma, separation conditions using Automated Multiple Development were selected in each case to provide lipid classes as zones narrow enough to ensure a direct transfer of them to ESI-MS. The respective zone of interest can be selected at will...
March 23, 2018: Journal of AOAC International
Huairong Zhang, Binxiao Li, Zhaomei Sun, Hong Zhou, Shusheng Zhang
Cancer therapies based on reactive oxygen species (ROS) have emerged as promising clinical treatments. Electrochemiluminescence (ECL) technology has also attracted considerable attention in the field of clinical diagnosis. However, studies about the integration of ECL diagnosis and ROS cancer therapy are very rare. Here we introduce a novel strategy that employs ECL technology and ROS to fill the above vacancy. Briefly, an ITO electrode was electrodeposited with polyluminol-Pt NPs composite films and modified with aptamer DNA to capture HL-60 cancer cells with high specificity...
December 1, 2017: Chemical Science
Bong Geun Cha, Jaeyun Kim
Biomedical investigations using mesoporous silica nanoparticles (MSNs) have received significant attention because of their unique properties including controllable mesoporous structure, high specific surface area, large pore volume, and tunable particle size. These unique features make MSNs suitable for simultaneous diagnosis and therapy with unique advantages to encapsulate and load a variety of therapeutic agents, deliver these agents to the desired location, and release the drugs in a controlled manner...
March 22, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
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