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https://www.readbyqxmd.com/read/27912066/cell-type-specific-optical-recording-of-membrane-voltage-dynamics-in-freely-moving-mice
#1
Jesse D Marshall, Jin Zhong Li, Yanping Zhang, Yiyang Gong, François St-Pierre, Michael Z Lin, Mark J Schnitzer
Electrophysiological field potential dynamics are of fundamental interest in basic and clinical neuroscience, but how specific cell types shape these dynamics in the live brain is poorly understood. To empower mechanistic studies, we created an optical technique, TEMPO, that records the aggregate trans-membrane voltage dynamics of genetically specified neurons in freely behaving mice. TEMPO has >10-fold greater sensitivity than prior fiber-optic techniques and attains the noise minimum set by quantum mechanical photon shot noise...
December 1, 2016: Cell
https://www.readbyqxmd.com/read/27910990/a-ph-responsive-sequential-disassembly-nanohybrid-for-mitochondrial-targeting
#2
Lijia Li, Wei Sun, Lian Li, Yuanyuan Liu, Lei Wu, Fengling Wang, Zhou Zhou, Zhirong Zhang, Yuan Huang
Cationic materials have been reported as promising tools for targeting to mitochondria which are the "power houses" and "metabolic garbage keepers" of cells. However, their positive nature also restricts their in vivo application due to the quick clearance. Herein, we fabricated a nanohybrid consisting of the pH-responsive N-(2-hydroxypropyl)methacrylamide (HPMA) co-polymer (R-P) shells and positive mesoporous silica nanoparticle cores via electrostatic interaction. The anticancer drug, docetaxel (DTX), was encapsulated in the positive MSN cores (MSN-DTX)...
December 2, 2016: Nanoscale
https://www.readbyqxmd.com/read/27909104/loss-of-plasticity-in-the-d2-accumbens-pallidal-pathway-promotes-cocaine-seeking
#3
J A Heinsbroek, D N Neuhofer, W C Griffin, G S Siegel, A-C Bobadilla, Y M Kupchik, P W Kalivas
Distinct populations of D1- and D2-dopamine receptor expressing medium spiny neurons (D1-/D2-MSNs) comprise the nucleus accumbens, and activity in D1-MSNs promotes, while activity in D2-MSNs inhibits motivated behaviors. We used chemogenetics to extend D1-/D2-MSN cell specific regulation to cue-reinstated cocaine seeking in a mouse model of self-administration and relapse, and found that either increasing activity in D1-MSNs or decreasing activity in D2-MSNs augmented cue-induced reinstatement. Both D1- and D2-MSNs provide substantial GABAergic innervation to the ventral pallidum, and chemogenetic inhibition of ventral pallidal neurons blocked the augmented reinstatement elicited by chemogenetic regulation of either D1- or D2-MSNs...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27890656/nanoparticle-delivery-of-sirna-against-twist-to-reduce-drug-resistance-and-tumor-growth-in-ovarian-cancer-models
#4
Cai M Roberts, Sophia Allaf Shahin, Wei Wen, James B Finlay, Juyao Dong, Ruining Wang, Thanh H Dellinger, Jeffrey I Zink, Fuyuhiko Tamanoi, Carlotta A Glackin
Epithelial ovarian cancer (EOC) is the most deadly gynecologic malignancy on account of its late stage at diagnosis and frequency of drug resistant recurrences. Novel therapies to overcome these barriers are urgently needed. TWIST is a developmental transcription factor reactivated in cancers and linked to angiogenesis, metastasis, cancer stem cell phenotype, and drug resistance, making it a promising therapeutic target. In this work, we demonstrate the efficacy of TWIST siRNA (siTWIST) and two nanoparticle delivery platforms to reverse chemoresistance in EOC models...
November 24, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27875331/amine-functionalized-cubic-mesoporous-silica-nanoparticles-as-an-oral-delivery-system-for-curcumin-bioavailability-enhancement
#5
Sandy Budi Hartono, Lannie Hadisoewignyo, Yanan Yang, Anand Kumar Meka, Antaresti, Chengzhong Yu
In the present work, a simple method was used to develop composite curcumin-amine functionalized mesoporous silica nanoparticles (MSN). The nanoparticles were used to improve the bioavailability of curcumin in mice through oral administration. We investigated the effect of particle size on the release profile, solubility and oral bioavailability of curcumin in mice, including amine functionalized mesoporous silica micron-sized-particles (MSM) and MSN (100-200 nm). Curcumin loaded within amine functionalized MSN (MSN-A-Cur) had a better release profile and a higher solubility compared to amine MSM (MSM-A-Cur)...
December 16, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27871668/emerging-role-for-nucleus-accumbens-medium-spiny-neuron-subtypes-in-depression
#6
REVIEW
T Chase Francis, Mary Kay Lobo
The ventral striatum (nucleus accumbens) and its role in mood, reward, and motivation has been the focus of significant research. Despite this interest, little work has addressed cell type-specific distinctions in medium spiny neurons (MSNs), the main projection neurons in the nucleus accumbens and dorsal striatum, and their function in relation to stress and depression. Previous work has shown opposing roles for D1 and D2 receptor MSN subtypes in depression-like outcomes to stress, particularly in regard to repeated neuronal stimulation and excitatory transmission...
September 15, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27847225/mesoporous-silica-nanoparticle-based-enzyme-responsive-system-for-colon-specific-drug-delivery-through-guar-gum-capping
#7
Balmiki Kumar, Senthilguru Kulanthaivel, Animesh Mondal, Smruti Mishra, Biplab Banerjee, Asim Bhaumik, Indranil Banerjee, Supratim Giri
In the global context of increasing colonic diseases, colon specific oral drug delivery systems have shown promise as an effective therapeutic modality. Herein, we developed a mesoporous silica nanoparticle (MSN) based enzyme responsive materials for colon specific drug delivery. We have utilized guar gum, a natural carbohydrate polymer as a capping layer to contain a model drug, such as 5-flurouracil (5FU) within the mesoporous channels of MSN. Analytical characterization including electron microscopy, PXRD, nitrogen sorption, thermogravimetric analysis and FTIR, confirmed that the synthesized MSN with size less than 100nm is of MCM-41type...
October 29, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27833123/ni-co-bimetal-nanowires-filled-multiwalled-carbon-nanotubes-for-the-highly-sensitive-and-selective-non-enzymatic-glucose-sensor-applications
#8
K Ramachandran, T Raj Kumar, K Justice Babu, G Gnana Kumar
The facile, time and cost efficient and environmental benign approach has been developed for the preparation of Nickel (Ni)-Cobalt (Co) alloy nanowires filled multiwalled carbon nanotubes (MWCNTs) with the aid of mesoporous silica nanoparticles (MSN)/Ni-Co catalyst. The controlled incorporation of Ni-Co nanostructures in the three dimensional (3D) pore structures of MSN yielded the catalytically active system for the MWCNT growth. The inner surface of MWCNTs was quasi-continuously filled with face-centered cubic (fcc) structured Ni-Co nanowires...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818324/the-sigma-1-receptor-mediates-the-beneficial-effects-of-pridopidine-in-a-mouse-model-of-huntington-disease
#9
Daniel Ryskamp, Jun Wu, Michal Geva, Rebecca Kusko, Iris Grossman, Michael Hayden, Ilya Bezprozvanny
The tri-nucleotide repeat expansion underlying Huntington disease (HD) results in corticostriatal synaptic dysfunction and subsequent neurodegeneration of striatal medium spiny neurons (MSNs). HD is a devastating autosomal dominant disease with no disease-modifying treatments. Pridopidine, a postulated "dopamine stabilizer", has been shown to improve motor symptoms in clinical trials of HD. However, the target(s) and mechanism of action of pridopidine remain to be fully elucidated. As binding studies identified sigma-1 receptor (S1R) as a high-affinity receptor for pridopidine, we evaluated the relevance of S1R as a therapeutic target of pridopidine in HD...
November 3, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27818251/mesoporous-silica-nanoparticles-as-a-new-carrier-methodology-in-the-controlled-release-of-the-active-components-in-a-polypill
#10
Antonio L Doadrio, José M Sánchez-Montero, Juan C Doadrio, Antonio J Salinas, María Vallet-Regí
Polypill is a medication designed for preventing heart attacks through a combination of drugs. Current formulations contain blood pressure-lowering drugs and others, such statins or acetylsalicylic acid. These drugs exhibit different physical chemical features, and consequently different release kinetics. Therefore, the concentration in plasma of some of them after the release process can be out of the therapeutic range. This paper investigates a new methodology for the control dosage of a polypill recently reported containing hydrochlorothiazide, amlodipine, losartan and simvastatin in a 12...
November 3, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27793790/in-vitro-and-in-vivo-assessment-of-edta-modified-silica-nano-spheres-with-supreme-capacity-of-iron-capture-as-a-novel-antidote-agent
#11
Fatemeh Farjadian, Sahar Ghasemi, Reza Heidari, Soliman Mohammadi-Samani
Mesoporous silica nanoparticles having structure of MCM-41 category with amine and EDTA functional groups in the pores were prepared using a co-condensation reaction. The synthetic steps eventuated in the mesoporous silica nanoparticles with spherical sizes lower than 50nm supposed to have high surface area. The nanoparticles' structure and functionality were characterized by FTIR spectroscopy and CHN analysis and the topography were examined by SEM and TEM and hydrodynamic sizes were demonstrated by DLS. The crystallinity and mesoporous pattern were figured out by XRD technique...
October 25, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27793700/suppressive-regulation-of-lateral-inhibition-between-medium-spiny-neurons-via-dopamine-d1-receptors-in-the-rat-nucleus-accumbens-shell
#12
Shuntaro Kohnomi, Katsuko Ebihara, Masayuki Kobayashi
The nucleus accumbens (NAc) shell is closely associated with reward, psychiatric disorders (depression or schizophrenia), and drug abuse. Dopamine, released from the ventral tegmental area, is involved in these physiological functions and pathophysiological changes of NAc shell. Medium spiny neurons (MSNs), which are only GABAergic projection neurons in NAc, also innervate adjacent MSNs, forming the lateral inhibition network. Previous studies demonstrate that dopamine suppresses the lateral inhibition via D2-like (D2 and D3) receptors...
October 25, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27784244/advances-in-functionalized-mesoporous-silica-nanoparticles-for-tumor-targeted-drug-delivery-and-theranostics
#13
Wenjia Zhang, Mengrui Liu, Anchang Liu, Guangxi Zhai
In recent years, nanocarriers have played increasingly significant roles in cancer therapy. Among various nanoplatforms, mesoporous silica nanoparticles (MSNs) have been given serious attention due to their good colloid stablity, tunable pore sizes, extensive drug loading capacity and easily modified surface. In this review, functionalized MSNs are introduced as an efficient nanocarrier for cancer treatment. First, MSN preparation strategies are generally introduced. Next, passive and active tumor targeting methods for the functionalization of MSNs are reviewed...
October 25, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27776334/improved-controlled-release-of-protein-from-expanded-pore-mesoporous-silica-nanoparticles-modified-with-co-functionalized-poly-n-isopropylacrylamide-and-poly-ethylene-glycol-pnipam-peg
#14
Erick Yu, Allison Lo, Linda Jiang, Bradley Petkus, Nazar Ileri Ercan, Pieter Stroeve
Novel pore-expanded mesoporous silica nanoparticles (MSNs) with pore sizes of approximately 11nm were synthesized and modified with thermoresponsive, poly(n-isopropylacrylamide) (PNIPAM) gating groups on the nanoparticle exterior surface and in addition with poly(ethylene-glycol) (PEG) within the porous interior to minimize protein adsorption. PEG traditionally has been grafted to the nanoparticle exterior to minimize non-specific binding and interactions with the biological environment, but due to the templating mechanism of MSN synthesis, both the pore interior and nanoparticle surface can be separately modified...
October 17, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27775016/predictable-components-of-enso-evolution-in-real-time-multi-model-predictions
#15
Zhihai Zheng, Zeng-Zhen Hu, Michelle L'Heureux
The most predictable components of the El Niño-Southern Oscillation (ENSO) evolution in real-time multi-model predictions are identified by applying an empirical orthogonal function analysis of the model data that maximizes the signal-to-noise ratio (MSN EOF). The normalized Niño3.4 index is analyzed for nine 3-month overlapping seasons. In this sense, the first most predictable component (MSN EOF1) is the decaying phase of ENSO during the Northern Hemisphere spring, followed by persistence through autumn and winter...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27771513/ph-sensitive-mesoporous-silica-nanoparticles-anticancer-prodrugs-for-sustained-release-of-ursolic-acid-and-the-enhanced-anti-cancer-efficacy-for-hepatocellular-carcinoma-cancer
#16
Tao Li, Xiufen Chen, Yajun Liu, Lulu Fan, Liqing Lin, Yu Xu, Sijia Chen, Jingwei Shao
Ursolic acid (UA) as a nature product exhibits good anti-cancer activity, low toxicity, and good liver protection features. However, the low-solubility and poor bioavailability restrict its further clinical application. To overcome this problem, a pH-sensitive prodrug delivery system (UA@MSN-UA) that incorporated acid-sensitive linkage between drug and silica-based mesoporous nanosphere (MSN) was successfully designed and synthesized. The physicochemical properties of the UA@MSN-UA nanoparticles were investigated for shape, particle size, zeta potential, nitrogen adsorption-desorption and infrared (IR) spectroscopy...
October 19, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27768270/versatile-antireflection-coating-for-plastics-partial-embedding-of-mesoporous-silica-nanoparticles-onto-substrate-surface
#17
Norihiro Mizoshita, Hiromitsu Tanaka
Antireflection (AR) coating for transparent plastic substrates is constructed by partially embedding mesoporous silica nanoparticles (MSNs) onto the surface of the substrates. Simulation of optical properties of polymer substrates coated with a single-particle MSN layer indicates that the surface has a low and graded refractive index in the direction of the thickness and effectively decreases the reflectance of visible light. The MSN-coated surfaces can be prepared by exposure of the MSN-painted substrates to a solvent vapor, irrespective of the shape of the polymer substrates...
October 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27768137/response-to-the-value-of-mentoring-in-nursing-an-honor-and-a-gift
#18
Adrienne Schleisman
I would like to thank Marcia Gruber-Page, MSN, MS, RN, for highlighting the value of mentorships for the profession of nursing (Gruber-Page, 2016). As she emphasized, mentorships in the workplace contribute to the professional success of the mentor and mentee. Another population that is in need of sound guidance during a critical stage of professional development is undergraduate student nurses. 
.
November 1, 2016: Oncology Nursing Forum
https://www.readbyqxmd.com/read/27758707/new-psychoactive-substances-3-methoxyphencyclidine-3-meo-pcp-and-3-methoxyrolicyclidine-3-meo-pcpy-metabolic-fate-elucidated-with-rat-urine-and-human-liver-preparations-and-their-detectability-in-urine-by-gc-ms-lc-high-resolution-msn-and-lc-high-resolution
#19
Julian A Michely, Sascha K Manier, Achim T Caspar, Simon D Brandt, Jason Wallach, Hans H Maurer
3-Methoxyphencyclidine (3-MeO-PCP) and 3-methoxyrolicyclidine (3-MeO-PCPy) are two new psychoactive substances (NPS). The aims of the present study were the elucidation of their metabolic fate in rat and pooled human liver microsomes (pHLM), the identification of the cytochrome P450 (CYP) isoenzymes involved, and the detectability using standard urine screening approaches (SUSA) after intake of common users' doses using gas chromatography-mass spectrometry (GC-MS), liquid chromatography-multi-stage mass spectrometry (LC-MSn), and liquid chromatography-high-resolution tandem mass spectrometry (LC-HR-MS/MS)...
October 18, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27751944/hippocampal-to-basal-forebrain-transport-of-mn-2-is-impaired-by-deletion-of-klc1-a-subunit-of-the-conventional-kinesin-microtubule-based-motor
#20
Christopher S Medina, Octavian Biris, Tomas L Falzone, Xiaowei Zhang, Amber J Zimmerman, Elaine L Bearer
Microtubule-based motors carry cargo back and forth between the synaptic region and the cell body. Defects in axonal transport result in peripheral neuropathies, some of which are caused by mutations in KIF5A, a gene encoding one of the heavy chain isoforms of conventional kinesin-1. Some mutations in KIF5A also cause severe central nervous system defects in humans. While transport dynamics in the peripheral nervous system have been well characterized experimentally, transport in the central nervous system is less experimentally accessible and until now not well described...
October 14, 2016: NeuroImage
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