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Korsakoff's Syndrome

Yvonne C M Rensen, Joukje M Oosterman, Serge J W Walvoort, Paul A T M Eling, Roy P C Kessels
INTRODUCTION: Intrusions on verbal memory tests have been used as an index for clinical confabulation. Severe memory impairments in combination with executive dysfunction have been suggested to be the underlying mechanism of confabulation, but to date, this relation is unclear. The aim of this study was (a) to examine the relation between (different types of) intrusions and confabulations in a large sample of confabulating patients with Korsakoff's syndrome (KS) and (b) to investigate whether different measures of executive functioning and memory performance are related to provoked and spontaneous confabulation...
September 5, 2016: Journal of Clinical and Experimental Neuropsychology
Hiroyoshi Inaba, Takuya Kishimoto, Satoru Oishi, Kan Nagata, Shunsuke Hasegawa, Tamae Watanabe, Satoshi Kida
Patients with severe Wernicke-Korsakoff syndrome (WKS) associated with vitamin B1 (thiamine) deficiency (TD) show enduring impairment of memory formation. The mechanisms of memory impairment induced by TD remain unknown. Here, we show that hippocampal degeneration is a potential microendophenotype (an endophenotype of brain disease at the cellular and synaptic levels) of WKS in pyrithiamine-induced thiamine deficiency (PTD) mice, a rodent model of WKS. PTD mice show deficits in the hippocampus-dependent memory formation, although they show normal hippocampus-independent memory...
December 2016: Bioscience, Biotechnology, and Biochemistry
J Bradley Segal, Marc A Bouffard, Gottfried Schlaug
No abstract text is available yet for this article.
October 1, 2016: JAMA Neurology
Serge J W Walvoort, Paul T van der Heijden, Arie J Wester, Roy P C Kessels, Jos I M Egger
Patients with Korsakoff's syndrome (KS) typically have difficulties in recognizing the impact of their alcohol-related cognitive deficits on daily-life functioning. In this study, mean scores on self-reported complaints (measured with Minnesota Multiphasic Personality Inventory-2-Restructured Form; MMPI-2-RF) and cognitive performance (measured with the Wechsler Adult Intelligence Scale-Third edition; WAIS-III; and the California Verbal Learning Test; CVLT) are compared between two matched patient groups with severe (KS) and mild alcohol-related cognitive disorders or non KS (NKS)...
November 30, 2016: Psychiatry Research
Christopher S Sharp, Michael P Wilson, Kimberly Nordstrom
No abstract text is available yet for this article.
October 2016: Journal of Emergency Medicine
S V Kotov, A I Lobakov, E V Isakova, G A Stashuk, T V Volchenkova
AIM: To study the diagnosis and treatment of non-alcoholic Wernicke-Korsakoff syndrome (WKS). MATERIAL AND METHODS: Eight patients (5 men and 3 women), mean age 38,9±1,4 years, with WKS developed due to acute gastrointestinal tract (GIT) disease (3 patients), the exacerbation of chronic GIT disease with malabsorption (2 patients) and after surgery on the upper GIT (3 patients) were included in the study. RESULTS: The disease manifested with consciousness disturbance, symptoms of ataxia, eye movement disorders and bulbar syndrome that developed after 24-48 h...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Jan W Wijnia, Erik Oudman, Willem A van Gool, André I Wierdsma, Esmay L Bresser, Jan Bakker, Albert van de Wiel, Cornelis L Mulder
BACKGROUND: Wernicke encephalopathy can have different clinical outcomes. Although infections may precipitate the encephalopathy itself, it is unknown whether infections also modify the long-term outcome in patients developing Korsakoff syndrome. OBJECTIVE: To determine whether markers of infection, such as white blood cell (WBC) counts and absolute neutrophil counts in the Wernicke phase, are associated with cognitive outcomes in the end-stage Korsakoff syndrome...
June 18, 2016: Psychosomatics
Serge Jw Walvoort, Paul T van der Heijden, Roy Pc Kessels, Jos Im Egger
AIM: Impaired illness insight may hamper treatment outcome in patients with alcohol-related cognitive deficits. In this study, a short questionnaire for the assessment of illness insight (eg, the Q8) was investigated in patients with Korsakoff's syndrome (KS) and in alcohol use disorder (AUD) patients with mild neurocognitive deficits. METHODS: First, reliability coefficients were computed and internal structure was investigated. Then, comparisons were made between patients with KS and patients with AUD...
2016: Neuropsychiatric Disease and Treatment
Sachio Matsushita, Susumu Higuchi
This article reviews studies examining the relationship between alcohol consumption and dementia. Several studies have found that light to moderate alcohol consumption might be associated with decreased dementia risk compared to alcohol abstention. However, not all studies drew the same conclusion and there is no consensus regarding decreased dementia risk related to light to moderate alcohol consumption. The methodological limitations of these studies also need to be considered. For example, definition of alcohol consumption varies with studies...
July 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
Elie Isenberg-Grzeda, Sudhanshu Rahane, Antonio P DeRosa, Janet Ellis, Stephen E Nicolson
Wernicke-Korsakoff syndrome in patients with cancer is understudied. Much of what is known-that significant under-recognition and delays in treatment exist-comes from studies of alcohol misuse disorders or non-alcohol-related Wernicke-Korsakoff syndrome in patients. We investigated the frequency and associated features of cancer-related Wernicke-Korsakoff syndrome in the published literature. We included 90 articles reporting on 129 patients. Only 38 (30%) of 128 patients with data available exhibited the entire triad of classic features of Wernicke-Korsakoff syndrome: confusion, ataxia, and ophthalmoplegia or nystagmus...
April 2016: Lancet Oncology
Natalie M Zahr, Edith V Sullivan, Torsten Rohlfing, Dirk Mayer, Amy M Collins, Richard Luong, Adolf Pfefferbaum
RATIONALE: Serious neurological concomitants of alcoholism include Wernicke's encephalopathy (WE), Korsakoff's syndrome (KS), and hepatic encephalopathy (HE). OBJECTIVES: This study was conducted in animal models to determine neuroradiological signatures associated with liver damage caused by carbon tetrachloride (CCl4), thiamine deficiency caused by pyrithiamine treatment, and nonspecific nutritional deficiency caused by food deprivation. METHODS: Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) were used to evaluate brains of wild-type Wistar rats at baseline and following treatment...
July 2016: Psychopharmacology
Mohamad El Haj, Roy P C Kessels, Christian Matton, Jean-Eudes Bacquet, Laurent Urso, Gaëlle Cool, Florence Guidez, Stéphanie Potier, Jean-Louis Nandrino, Pascal Antoine
BACKGROUND: Context memory, or the ability to remember the context in which an episodic event has occurred (e.g., where and when an event took place), has been found to be compromised in Korsakoff's syndrome. This study examined whether a similar deficit would be observed for destination memory, that is, the ability to remember to whom an information was previously transmitted. METHODS: Patients with Korsakoff's syndrome and healthy controls were instructed to tell proverbs to pictures of celebrities...
June 2016: Alcoholism, Clinical and Experimental Research
Jacqui Tedder, Laurie Miller, Sicong Tu, Michael Hornberger, Suncica Lah
OBJECTIVE: Remembering the past and imaging the future are both manifestations of 'mental time travel'. These processes have been found to be impaired in patients with bilateral hippocampal lesions. Here, we examined the question of whether future thinking is affected by other Papez circuit lesions, namely: damage to the mammillary bodies/fornix. METHOD: Case (SL) was a 43-year-old woman who developed dense anterograde and retrograde amnesia suddenly, as a result of Wernicke-Korsakoff's syndrome...
February 2016: Clinical Neuropsychologist
Mélanie Brion, Anne-Lise Pitel, Fabien D'Hondt
This perspective aims at underlining the usefulness of event-related potentials (ERP) to better understand the brain correlates of Korsakoff's syndrome (KS), a neuropsychiatric disease characterized by severe memory impairment and most frequently resulting as a neurological complication of alcohol-dependence (AD). While ERP have been broadly used in AD, it has up to now been very little applied in KS or in the comparison of KS and AD. Within the framework of dual-process models, an influential theory postulating that addictive states result from an imbalance between under-activated reflective system and over-activated automatic-affective one, this paper proposes: (1) a brief synthesis of the main results of ERP studies in AD and KS, and (2) new research avenues using ERP to identify the electrophysiological correlates of cognitive and emotional dysfunction in KS...
2016: Frontiers in Psychology
Joseph M Hall, Lisa M Savage
Exercise has been shown to improve cognitive functioning in a range of species, presumably through an increase in neurotrophins throughout the brain, but in particular the hippocampus. The current study assessed the ability of exercise to restore septohippocampal cholinergic functioning in the pyrithiamine-induced thiamine deficiency (PTD) rat model of the amnestic disorder Korsakoff Syndrome. After voluntary wheel running or sedentary control conditions (stationary wheel attached to the home cage), PTD and control rats were behaviorally tested with concurrent in vivo microdialysis, at one of two time points: 24-h or 2-weeks post-exercise...
April 2016: Experimental Neurology
Elie Isenberg-Grzeda, Yesne Alici, Vaios Hatzoglou, Christian Nelson, William Breitbart
BACKGROUND: Wernicke-Korsakoff Syndrome (WKS) is a neuropsychiatric syndrome caused by thiamine deficiency. Cancer predisposes to thiamine deficiency through various mechanisms. Although many case reports exist on nonalcoholic WKS in cancer, larger qualitative studies are lacking. METHOD: Retrospective study of patients admitted to a cancer hospital and diagnosed with WKS during routine care on a psychiatric consultation service. Only patients with at least 1 additional supporting feature (magnetic resonance imaging findings, low serum thiamine concentrations, or response to treatment) were included...
January 2016: Psychosomatics
N Cabé, A Laniepce, L Ritz, C Lannuzel, C Boudehent, F Vabret, F Eustache, H Beaunieux, A-L Pitel
Alcohol-related cognitive impairments are largely underestimated in clinical practice, even though they could limit the benefit of alcohol treatment and hamper the patient's ability to remain abstinent or to respect his/her therapeutic contract. These neuropsychological deficits can impact the management of patients well before the development of the well-known Korsakoff's syndrome. Indeed, even in the absence of ostensible neurological complications, excessive and chronic alcohol consumption results in damage of brain structure and function...
February 2016: L'Encéphale
Yongxing Zhou, Derrick Fox, Abhishek Anand, Amal Elhaj, Arushi Kapoor, Faranak Najibi, Han Kim, Roger Weir, Annapurni Jayam-Trouth
The Korsakoff syndrome is defined as "an abnormal mental state in which memory and learning are affected out of all proportion to other cognitive functions in an otherwise alert and responsive patient." Confabulation refers to false or erroneous memories arising, not deliberately, in the context of a neurological amnesia and is often thought of as pathognomonic of the Korsakoff syndrome. Although the exact pathophysiology is unknown, various studies have identified brain lesions in the thalami, mammillary bodies, and frontal cortex...
2015: Case Reports in Neurological Medicine
Marta Farré, Josep Maria Haro, Belchin Kostov, Carme Alvira, Ester Risco, Susana Miguel, Ester Cabrera, Adelaida Zabalegui
BACKGROUND: Due to the high prevalence of dementia, health care needs are increasing beyond existing formal resources. In Spain, it is the family that takes care of this disease. AIMS: To analyze the direct (health and non-health) and indirect economic costs related to care of people with dementia living with their informal caregiver in the home care/community environment, from the perspective of illness severity, associated comorbidity and social impact. DESIGN: Multicentric, descriptive study...
March 2016: International Journal of Nursing Studies
Yoshiyuki Nishio, Etsuro Mori
The anterior and mediodorsal thalamic nuclei form neuroanatomical networks supporting memory along with the mammillary body, medial temporal structures, prefrontal cortices and posterior cingulate cortex. In this review article, we discuss human diencephalic amnesic syndromes, including Wernicke-Korsakoff syndrome and amnesia associated with thalamic infarcts, and animal neuropsychological studies from a neuroanatomical network perspective. In addition, we suggest future research directions for understanding the functional roles of the anterior and mediodorsal thalamic nuclei in memory function based on findings from recent animal studies...
December 2015: Brain and Nerve, Shinkei Kenkyū No Shinpo
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