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Diabetic nephrology

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https://www.readbyqxmd.com/read/29866999/kidney-diseases-and-pregnancy-a-multidisciplinary-approach-for-improving-care-by-involving-nephrology-obstetrics-neonatology-urology-diabetology-bioethics-and-internal-medicine
#1
EDITORIAL
Giorgina Barbara Piccoli, Rossella Attini, Gianfranca Cabiddu
This multidisciplinary series is aimed at offering readers many opportunities to appreciate how a clinical and ethical approach to pregnancy has changed in patients with kidney diseases and with related conditions, including diabetes, hypertension, and immunologic diseases. Furthermore, this series aims to focus on the fact that many issues remain unreslved, that there are enormous gaps in knowledge, and that the bioethical approach needs to integrated in the clinical practice, which would allow for a deeper appreciation of different cultural and religious backgrounds...
June 4, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29804241/adiponectin-is-related-to-markers-of-endothelial-dysfunction-and-neoangiogenesis-in-diabetic-patients
#2
Teodor Kacso, Cosmina Ioana Bondor, Crina Claudia Rusu, Diana Moldovan, Dacian Trinescu, Laura Anca Coman, Maria Ticala, Alexandra Maria Gavrilas, Alina Ramona Potra
PURPOSE: Adiponectin an adipokine, produced by mature adipocyte, has an important effect on several aspects of endothelial function, including leukocyte adhesion (mediated by adhesion molecules like intercellular adhesion molecule 1 (ICAM1) endothelial cell selective adhesion molecule ESAM). Recently, it has been linked to vascular endothelial growth factor (VEGF)-modulated angiogenesis. ESAM might also be involved in modulating VEGF-dependent actions. We studied relationship of adiponectin to ESAM, ICAM1, and VEGF in type 2 diabetic patients (T2DP) with or without microvascular complications...
May 26, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29716870/role-of-leptin-and-dyslipidemia-in-chronic-kidney-disease
#3
Sabeela Noor, Faiza Alam, Syeda Sadia Fatima, Mahnur Khan, Rehana Rehman
Chronic kidney disease (CKD) patients are at an increased risk of cardiovascular complications and plasma leptin level is elevated in cardio renal syndrome. We wanted to explore leptin levels in patients with different stages of CKD and find its association with risk of cardiovascular disease. This cross-sectional study was conducted in Nephrology Department of Jinnah Post Graduate Medical Centre (JPMC) from January 2014 to September 2014. Group I comprised of controls (GFR=116±8.3, n = 44) acquired from general population, CKD patients were grouped as II, III and IV respectively with GFR; 85...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29705734/treatment-of-end-stage-renal-disease-with-continuous-ambulatory-peritoneal-dialysis-in-rural-guatemala
#4
Jillian Moore, Pablo Garcia, Peter Rohloff, David Flood
A 42-year-old indigenous Maya man presented to a non-profit clinic in rural Guatemala with signs, symptoms and laboratory values consistent with uncontrolled diabetes. Despite appropriate treatment, approximately 18 months after presentation, he was found to have irreversible end-stage renal disease (ESRD) of uncertain aetiology. He was referred to the national public nephrology clinic and subsequently initiated home-based continuous ambulatory peritoneal dialysis. With primary care provided by the non-profit clinic, his clinical status improved on dialysis, but socioeconomic and psychological challenges persisted for the patient and his family...
April 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29686787/pattern-duration-of-stay-and-outcomes-of-medical-admissions-a-report-from-teaching-community-hospital-in-assir-region-saudi-arabia
#5
Mushabab A Al-Ghamdi, Aref A Bin Abdulhak
Background : Population-based studies are the gold standard to understand the burden of different diseases, plan health care policy and resource allocation, and provide an accurate estimate of disease several disease indices including mortality. However, population-based studies are difficult to undertake in a resource-limited situation where no robust data bases and disease registries are available. Therefore, hospital-based cohorts may be used to inform about the community health. Objectives: We sought to study the pattern of disease causing admission, hospital stay, and outcomes of medical admissions to King Abdullah Hospital in Bisha in order to inform clinicians, public health professionals, and policymakers about the current status of diseases within the community in Bisha...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29657211/etiological-profile-of-chronic-kidney-disease-a-single-center-retrospective-hospital-based-study
#6
Manjuri Sharma, Prodip Doley, Himanab Jyoti Das
Chronic kidney disease (CKD) is one of the leading causes of chronic diseases globally, with rising incidence and prevalence. It is a major risk factor for cerebrovascular disease and coronary artery disease, which are the main causes of death in this population. The etiology of CKD is varied. This study was performed to evaluate the various etiologies of CKD among patients presenting to the Department of Nephrology, Guwahati Medical College, a tertiary referral center. A total of 5718 CKD patients were evaluated to identify the cause of CKD...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29657209/spectrum-of-biopsy-proven-renal-diseases-a-single-center-experience
#7
Lakshminarayana R Gopaliah, Indu Sudakaran, Seethalekshmy Vijayan Nalumakkal, Ranjit Narayanan, Biju Meckattuparamban Vareed
Kidney biopsy is one of the most important tools in the assessment of kidney disease as histopathological diagnosis promotes evidence-based practice in Nephrology. This study included 271 consecutive percutaneous kidney biopsies (145 males and 126 females) performed at EMS Memorial Cooperative Hospital, Perinthalmanna, Kerala, India, from September 2009 to March 2016. Among the biopsy-proven renal diseases (BPRD), primary glomerular diseases (PGD) were the most common (77.78%) followed by secondary glomerular diseases (SGD) (12...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29657204/urinary-tract-infection-in-renal-transplant-recipients-at-a-tertiary-care-center-in-india
#8
Debabrata Mukherjee, Sourabh Sharma, Ranjith K Nair, Bhaskar Datt, Dhawal Arora, Ananth Rao
Our objective was to determine incidence, predisposing factors, and microbiological profile of urinary tract infection (UTI) in renal transplant recipients in our center. This was cross-sectional observational study, conducted at the Department of Nephrology, Army Hospital Research and Referral, Delhi, India. Two hundred and ten renal transplant recipients were studied over one year. Out of 210 transplant recipients, 69 (32.86%) had UTI. Majority (59/69) had undergone live renal transplantation and 10 cases had received cadaveric grafts...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29656901/different-rates-of-progression-and-mortality-in-patients-with-chronic-kidney-disease-at-outpatient-nephrology-clinics-across-europe
#9
Katharina Brück, Kitty J Jager, Carmine Zoccali, Aminu K Bello, Roberto Minutolo, Kyriakos Ioannou, Francis Verbeke, Henry Völzke, Johan Arnlöv, Daniela Leonardis, Pietro Manuel Ferraro, Hermann Brenner, Ben Caplin, Philip A Kalra, Christoph Wanner, Alberto Martinez Castelao, Jose Luis Gorriz, Stein Hallan, Dietrich Rothenbacher, Dino Gibertoni, Luca De Nicola, Georg Heinze, Wim Van Biesen, Vianda S Stel
The incidence of renal replacement therapy varies across countries. However, little is known about the epidemiology of chronic kidney disease (CKD) outcomes. Here we describe progression and mortality risk of patients with CKD but not on renal replacement therapy at outpatient nephrology clinics across Europe using individual data from nine CKD cohorts participating in the European CKD Burden Consortium. A joint model assessed the mean change in estimated glomerular filtration rate (eGFR) and mortality risk simultaneously, thereby accounting for mortality risk when estimating eGFR decline and vice versa, while also correcting for the measurement error in eGFR...
June 2018: Kidney International
https://www.readbyqxmd.com/read/29651696/diversity-of-the-midstream-urine-microbiome-in-adults-with-chronic-kidney-disease
#10
Holly Kramer, Gina Kuffel, Krystal Thomas-White, Alan J Wolfe, Kavitha Vellanki, David J Leehey, Vinod K Bansal, Linda Brubaker, Robert Flanigan, Julia Koval, Anuradha Wadhwa, Michael J Zilliox
PURPOSE: To examine the characteristics of the midstream urine microbiome in adults with stage 3-5 non-dialysis-dependent chronic kidney disease (CKD). METHODS: Patients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m2 ) and diuretic use were recruited from outpatient nephrology clinics. Midstream voided urine specimens were collected using the clean-catch method. The bacterial composition was determined by sequencing the hypervariable (V4) region of the bacterial 16S ribosomal RNA gene...
June 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29629608/intravenous-pulses-of-methylprednisolone-to-treat-flares-of-immune-mediated-diseases-how-much-how-long
#11
A Danza, I Borgia, J I Narváez, A Baccelli, C Amigo, M Rebella, V Domínguez
Introduction Glucocorticoids are widely used in the treatment of immune-mediated diseases. Despite their widespread use, details on dosing, effectiveness and adverse effects are yet to be determined. Objective To know the current use of methylprednisolone (MTP) in the management of immune-mediated conditions, evaluating the relationship among doses, therapeutic response and adverse effects. Methodology A multicenter retrospective cohort study was designed, including patients who received intravenous pulses of MTP between 1 January 2013 and 12 December 2015 in three different hospitals in Uruguay...
June 2018: Lupus
https://www.readbyqxmd.com/read/29629274/current-characteristics-of-dialysis-therapy-in-korea-2016-registry-data-focusing-on-diabetic-patients
#12
Dong-Chan Jin, Sung-Ro Yun, Seoung Woo Lee, Sang-Woong Han, Won Kim, Jongha Park, Yong-Kyun Kim
Diabetic nephropathy is the most frequent cause of end-stage renal disease worldwide. Dialysis patients with diabetes mellitus (DM) have more complications and shorter survival duration than non-DM dialysis patients, requiring more clinical attention and difficult management. The registry committee of the Korean Society of Nephrology has collected data about dialysis therapy in Korea through an on-line registry program and analyzed the characteristics of patients. A survey of dialysis patients in 2016 showed that 50...
March 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29621990/risk-factors-for-long-term-mortality-in-patients-admitted-with-severe-infection
#13
J Francisco, I Aragão, T Cardoso
BACKGROUND: Severe infection is a main cause of mortality. We aim to describe risk factors for long-term mortality among inpatients with severe infection. METHODS: Prospective cohort study in a 600-bed university hospital in Portugal including all patients with severe infection admitted into intensive care, medical, surgical, hematology and nephrology wards over one-year period. The outcome of interest was 5-year mortality following infection. Variables of patient background and infectious episode were studied in association with the main outcome through multiple logistic regression...
April 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29615173/outcome-of-chronic-kidney-disease-patients-on-the-basis-of-referral-to-nephrologist-a-one-year-follow-up-study
#14
Muhammad Anees, Yasir Hussain, Muhammad Ibrahim, Irfan Ilahi, Sajjad Ahmad, Khushbakht Isma Asif, Amina Jameel
OBJECTIVE: To determine the outcome of chronic kidney disease (CKD) patients presenting for dialysis on the basis of referral to nephrologist. STUDY DESIGN: Observational study. PLACE AND DURATION OF STUDY: Nephrology Department of King Edward Medical University/Mayo Hospital, Lahore, from January 2014 to January 2016. METHODOLOGY: All patients who were presented in nephrology outpatients department and with the indication of dialysis were included in study...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29593879/the-role-of-desmopressin-in-the-management-of-severe-hypovolemic-hyponatremia-a-single-center-comparative-analysis
#15
Frank L Ward, Sheldon W Tobe, David M J Naimark
Background: The role of desmopressin (DDAVP) to prevent or treat rapid serum sodium concentration ([Na]s) correction during hyponatremia management remains unclear. Objective: To assess DDAVP use during the first 48 hours of severe, hypovolemic hyponatremia management. The primary study hypothesis was that the use of DDAVP would slow the rate of [Na]s correction compared with those not receiving DDAVP. Design: A retrospective, observational, comparison study...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29572627/functional-impairment-and-risk-of-mortality-in-patients-on-chronic-hemodialysis-results-of-the-lazio-dialysis-registry
#16
Maurizio Bossola, Claudia Marino, Anteo Di Napoli, Nera Agabiti, Luigi Tazza, Marina Davoli
BACKGROUND: Functional impairment is associated with adverse outcomes in older people, as well as in patients on chronic hemodialysis. The aim of this study was to evaluate if functional impairment represents a risk factor for reduced survival in patients on chronic hemodialysis. METHODS: All incident chronic hemodialysis patients of Lazio, a large region of central Italy, registered in the Dialysis and Transplant Lazio Region Registry (DTLRR) in the period 2008-2013 were considered eligible...
March 23, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29554891/public-knowledge-of-chronic-kidney-disease-evaluated-using-a-validated-questionnaire-a-cross-sectional-study
#17
Pankti A Gheewala, Gregory M Peterson, Syed Tabish R Zaidi, Matthew D Jose, Ronald L Castelino
BACKGROUND: Screening programs may help to address the burden of chronic kidney disease (CKD) in Australia. Public awareness is an important determinant of the uptake of screening programs. However, data on the public knowledge of CKD in Australia is lacking. The aim of this study was to develop a validated questionnaire and assess the Australian public knowledge of CKD. METHODS: A CKD knowledge questionnaire was developed after reviewing the literature and discussions with nephrology experts...
March 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29552340/a-retrospective-analysis-of-the-utility-and-safety-of-kidney-transplant-biopsies-by-nephrology-trainees-and-consultants
#18
Michael E Reschen, Andrea Mazzella, Edward Sharples
Background and aims: Dysfunction of a kidney transplant often requires histological sampling by percutaneous ultrasound-guided core needle biopsy. Transplant biopsy is more specialized than native kidney biopsy, the indications and complications are less well defined and in England are performed mainly by nephrologists. The aims of the study were to evaluate the adequacy and complication rate in living and deceased donor recipients according to training status of the nephrologist, assess the accuracy of physicians in predicting rejection, the threshold creatinine rise for biopsy, and the change in drug management post-biopsy...
April 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29522878/quantification-of-molecular-heterogeneity-in-kidney-tissue-by-targeted-proteomics
#19
K Johanna R Hoyer, Sebastian Dittrich, Malte P Bartram, Markus M Rinschen
Renal diseases are driven by alterations in the entity of proteins within the kidney, at the level of single cells, nephron subunits (such as glomerulus and tubule), tissues and body fluids. Histologically, kidney diseases are extremely heterogeneous. Mass-spectrometry based proteomics provides a unique opportunity to interrogate heterogeneity and dynamics of various proteome layers within the kidney to better understand physiology and pathophysiology, and to translate signaling networks into therapies. Yet, the success of this endeavor will largely depend on improving proteomic data acquisition methods toward increased reproducibility...
March 6, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29481564/short-term-renal-outcomes-following-acute-kidney-injury-among-dengue-patients-a-follow-up-analysis-from-large-prospective-cohort
#20
Tauqeer Hussain Mallhi, Amer Hayat Khan, Azreen Syazril Adnan, Azmi Sarriff, Yusra Habib Khan, Siew Hua Gan
BACKGROUND: Despite myriad improvements in the care of dengue patients, acute kidney injury (AKI) remained least appreciated intricacy of dengue infection. Exiting literature does not provide any information on renal outcomes among dengue patients surviving an episode of AKI. METHODS: Dengue patients who developed AKI were followed up for post-discharge period of three months and renal recovery was assessed by using recovery criteria based on different thresholds of serum creatinine (SCr) and estimated glomerular filtration rates (eGFR)...
2018: PloS One
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