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Exhaled breath condensate

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https://www.readbyqxmd.com/read/29319364/comparative-study-of-il-33-and-il-6-levels-in-different-respiratory-samples-in-mild-to-moderate-asthma-and-copd
#1
Katarzyna Gorska, Patrycja Nejman-Gryz, Magdalena Paplinska-Goryca, Piotr Korczynski, Monika Prochorec-Sobieszek, Rafal Krenke
IL-6 and IL-33 are involved in the inflammatory process in obstructive lung diseases. In contrast to IL-6, few data on the expression of IL-33 in different biological samples from asthma and COPD patients are available. The aim was to evaluate the expressions of IL-33 and IL-6 in bronchial mucosa and to compare these expressions with the concentrations of both cytokines in various respiratory samples from patients with mild-to-moderate asthma and COPD. Serum, induced sputum and exhaled breath condensate IL-6 and IL-33 levels, as well as their expression in bronchial mucosa were evaluated in 22 asthma and 33 COPD patients...
January 10, 2018: COPD
https://www.readbyqxmd.com/read/29316316/serum-but-not-exhaled-breath-condensate-periostin-level-is-increased-in-competitive-athletes
#2
Marcin Kurowski, Janusz Jurczyk, Marzanna Jarzębska, Aleksandra Wardzyńska, Hubert Krysztofiak, Marek L Kowalski
INTRODUCTION: Periostin is a matricellular protein expressed by many tissues. Its release may be enhanced, among others, through mechanical stimulation of muscles and bones as well as by cytokines of allergic inflammation. OBJECTIVES: Our aim was to assess periostin levels in serum and exhaled breath condensate (EBC) of professional athletes, asthmatics and healthy controls. We also sought to determine whether acute treadmill exercise influences serum and EBC periostin...
January 8, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29284685/oxidative-stress-biomarkers-and-asthma-characteristics-in-adults-of-the-egea-study
#3
Miora Andrianjafimasy, Farid Zerimech, Zeina Akiki, Helene Huyvaert, Nicole Le Moual, Valérie Siroux, Régis Matran, Orianne Dumas, Rachel Nadif
Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29280625/water-resistant-polymeric-acid-membrane-catalyst-for-acetone-detection-in-the-exhaled-breath-of-diabetics
#4
Adam D Worrall, Zexin Qian, Jonathan Bernstein, Anastasios P Angelopoulos
Endogenous volatile organic compounds (VOC's) such as acetone in exhaled human breath are associated with metabolic conditions in the bloodstream. Development of compact, rapid detectors of exhaled breath chemical compo-sition in clinical settings is challenging due to the small sample size that can be collected during a single exhalation as well as spectroscopic interference by the abundance of water. In this paper, we show that the activity of a catalytic polymer membrane (Nafion® 117) toward the heterogeneous condensation reaction of immobilized resorcinol reagent with gas-phase acetone can be preserved even at 100% ambient relative humidity through the incorporation of organic acids such as vanillic or tiglic...
December 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29273025/exhaled-breath-condensate-metabolome-clusters-for-endotype-discovery-in-asthma
#5
Anirban Sinha, Koundinya Desiraju, Kunal Aggarwal, Rintu Kutum, Siddhartha Roy, Rakesh Lodha, S K Kabra, Balaram Ghosh, Tavpritesh Sethi, Anurag Agrawal
BACKGROUND: Asthma is a complex, heterogeneous disorder with similar presenting symptoms but with varying underlying pathologies. Exhaled breath condensate (EBC) is a relatively unexplored matrix which reflects the signatures of respiratory epithelium, but is difficult to normalize for dilution. METHODS: Here we explored whether internally normalized global NMR spectrum patterns, combined with machine learning, could be useful for diagnostics or endotype discovery...
December 22, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29244031/transition-and-post-transition-metals-in-exhaled-breath-condensate
#6
Andrew Ghio, Michael C Madden, Charles R Esther
Water vapor in expired air, as well as dispersed non-volatile components, condense onto a cooler surface after exiting the respiratory tract. This exhaled breath condensate (EBC) provides a dilute sampling of the epithelial lining fluid. Accordingly, the collection of EBC imparts a capacity to provide biomarkers of injury preceding clinical disease. Concentrations of transition and post-transition metals in EBC are included among these endpoints. Iron and zinc are those metals in highest concentration and are measurable in all EBC samples from healthy subjects; other metals are most frequently either at or below the level of detection in this group...
December 15, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29241018/older-women-exhibit-greater-airway-8-isoprostane-responses-to-strenuous-exercise-compared-to-older-men-and-younger-controls
#7
Stephanie P Kurti, Sam R Emerson, Joshua R Smith, Sara K Rosenkranz, Samantha A Alexander, Garrett M Lovoy, Craig A Harms
INTRODUCTION: Development of late-onset respiratory diseases is associated with elevated 8-isoprostane, a marker of oxidative stress, in the airways. However, sex differences exist in development of these diseases. Using an exhaustive exercise bout as a physiological stressor may elucidate whether there is a sex difference with aging in pre- to post-exercise airway 8-isoprostane generation. PURPOSE: To determine whether older women exhibit a greater airway 8-isoprostane response to exhaustive exercise compared to older men and younger controls...
December 14, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29236512/exhaled-breath-condensate-as-an-alternative-sample-for-drug-monitoring
#8
Maryam Khoubnasabjafari, Elaheh Rahimpour, Abolghasem Jouyban
No abstract text is available yet for this article.
December 13, 2017: Bioanalysis
https://www.readbyqxmd.com/read/29189203/proteomic-characterization-of-human-exhaled-breath-condensate
#9
Maud Lacombe, Caroline Marie-Desvergne, Florence Combes, Alexandra Kraut, Christophe Bruley, Yves Vandenbrouck, Véronique Chamel Mossuz, Yohann Couté, Virginie Brun
To improve biomedical knowledge and to support biomarker discovery studies, it is essential to establish comprehensive proteome maps for human tissues and biofluids, and to make them publicly accessible. In this study, we performed an in-depth proteomics characterization of exhaled breath condensate (EBC), a sample obtained non-invasively by condensation of exhaled air that contains submicron droplets of airway lining fluid. Two pooled samples of EBC, each obtained from 10 healthy donors, were processed using a straightforward protocol based on sample lyophilization, in-gel digestion and liquid chromatography tandem-mass spectrometry (LC-MS/MS) analysis...
November 30, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29186897/non-coding-rnas-in-pediatric-airway-diseases
#10
REVIEW
Beata Narożna, Wojciech Langwiński, Aleksandra Szczepankiewicz
Non-coding RNAs (ncRNAs) are involved in the regulation of numerous biological processes and pathways and therefore have been extensively studied in human diseases. Previous reports have shown that non-coding RNAs play a crucial role in the pathogenesis and aberrant regulation of respiratory diseases. The altered expression of microRNAs (miRNAs) and long noncoding RNAs in blood and also locally in sputum or exhaled breath condensate influences lung function, immune response, and disease phenotype and may be used for the development of biomarkers specific for airway disease...
November 27, 2017: Genes
https://www.readbyqxmd.com/read/29162553/exhaled-nitric-oxide-and-vascular-endothelial-growth-factor-as-predictors-of-cold-symptoms-after-stress
#11
Thomas Ritz, Ana F Trueba, Pia D Vogel, Richard J Auchus, David Rosenfield
OBJECTIVE: Prior research has demonstrated that psychosocial stress is associated with respiratory infections. Immunologic, endocrine, and cardiovascular predictors of such infections have been explored with varying success. We therefore sought to study the unexplored role of airway mucosal immunity factors, nitric oxide (NO) and vascular endothelial growth factor (VEGF). NO is secreted by airway epithelial cells as part of the first line of defense against bacteria, viruses, and fungi...
November 18, 2017: Biological Psychology
https://www.readbyqxmd.com/read/29146889/exhaled-markers-of-anti-oxidant-activity-and-oxidative-stress-in-stable-cystic-fibrosis-patients-with-moderate-lung-disease
#12
Lucia Spicuzza, Giuseppe Fabio Parisi, Lucia Tardino, Nicola Ciancio, Raffaella Nenna, Fabio Midulla, Salvatore Leonardi
The sustained imbalance between oxidant and antioxidant species contributes to lung damage in patients with cystic fibrosis (CF). Glutathione (GSH) is an important component of the antioxidant defense in the airways epithelial lining fluid and its transportation out of the cells may be altered in CF. The aim of this study was to assess the oxidants/anti-oxidants balance in the airways of patients with CF. We measured the concentrations of GSH, the total antioxidant capacity and the concentration of 8-iso-prostaglandin F2α (8-isoprostane), a marker of oxidative stress, in the exhaled breath condensate of 17 non-smoking patients with CF, in stable phase, and in 17 age-matched healthy subjects...
November 17, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29104183/exhaled-breath-aerosol-eba-the-simplest-non-invasive-medium-for-public-health-and-occupational-exposure-biomonitoring
#13
Joachim D Pleil, Ariel Wallace, Michael C Madden
Exhaled breath collection has long been recognized as requiring the least invasive methods of the biological fluids and so is preferred for environmental and public health studies. This commentary describes how breath biomonitoring is generally preferred for certain logistical reasons in public health and occupational biomonitoring. Three different fractions of exhaled breath are considered: gas-phase, liquid condensate, and aerosols. The focus is on the exhaled breath aerosol (EBA) fraction and the development of targeted sampling and analysis methods...
November 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29098476/influence-of-air-pollution-on-airway-inflammation-and-disease-activity-in-childhood-systemic-lupus-erythematosus
#14
Andressa Guariento Ferreira Alves, Maria Fernanda de Azevedo Giacomin, Alfésio Luis Ferreira Braga, Adriana Maluf Elias Sallum, Luiz Alberto Amador Pereira, Luis Carlos Farhat, Fernando Louzada Strufaldi, Ana Julia de Faria Coimbra Lichtenfels, Tômas de Santana Carvalho, Naomi Kondo Nakagawa, Clovis Artur Silva, Sylvia Costa Lima Farhat
Exposure to fine particles may trigger pulmonary inflammation/systemic inflammation. The objective of this study was to investigate the association between daily individual exposure to air pollutants and airway inflammation and disease activity in childhood-onset systemic lupus erythematosus (cSLE) patients. A longitudinal panel study was carried out in 108 consecutive appointments with cSLE patients without respiratory diseases. Over four consecutive weeks, daily individual measures of nitrogen dioxide (NO2), fine particulate matter (PM2...
November 2, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29084127/green-coffee-been-exposure-and-symptoms-in-dock-workers-in-trieste-italy
#15
Anna Gasperazzo, Paolo Toffanin, Francesca Larese Filon
BACKGROUND: Green coffee workers can develop allergic symptoms due to green coffee beans (GCB) or to castor bean (CB) that can contaminate sacks used for the transportation. Data are limited in literature and a previous study performed in Trieste demonstrated allergic symptoms in 14.3% of dockworkers handling GCB. OBJECTIVES: To evaluate symptoms and exposure to GCB ultrafine particles in Trieste dockworkers. METHODS: Workers involved in GCB sacks transportation, storage and opening were asked to fill out a questionnaire on allergic respiratory symptoms...
October 27, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29083318/obstructive-sleep-apnea-patients-can-be-identified-by-ion-mobility-spectrometry-derived-smell-prints-of-different-biological-materials
#16
Timm Greulich, Hannes Fischer, Dirk Lubbe, Christoph Nell, Joerg Ingo Baumbach, Ulrich Koehler, Tobias Boeselt, Claus Vogelmeier, Andreas Koczulla
The analysis of sleep apnoea syndrome (OSAS) is time- and cost-intensive. A number of studies demonstrated that the non-invasive analysis of exhaled breath may be suitable to distinguish between OSAS patients and healthy subjects (HS). Methods/Population: We included OSAS patients (n=15) and HS (n=15) in this diagnostic proof-of-concept-study. All participants underwent polygraphy to verify or exclude OSAS and performed spirometry to exclude pulmonary ventilatory diseases. The VOC profile of exhaled breath and of the headspaces over exhaled breath condensate, pharyngeal washing fluid, and serum was measured using ion mobility spectrometry (BioScout®) and an e-nose (Cyranose® 320)...
October 30, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29078843/correlation-between-tumor-necrosis-factor-%C3%AE-and-interleukin-1%C3%AE-in-exhaled-breath-condensate-and-pulmonary-function
#17
Xuefeng Lin, Yichu Fan, Xiaodong Wang, Mingyou Chi, Xin Li, Xun Zhang, Daqiang Sun
BACKGROUND: Exhaled breath condensate (EBC) has emerged as a noninvasive method for assessing inflammation in lung diseases. Our aim is to investigate the correlation between tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) in EBC and in lung tissue, and between these values in EBC with pulmonary function tests in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: To ensure the availability of lung tissue, 60 patients undergoing resection for early lung cancer were divided into 3 groups: a COPD treatment group, a COPD control group and a non-COPD group...
October 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29063162/exhaled-breath-condensate-methods-adapted-from-human-studies-using-longitudinal-metabolomics-for-predicting-early-health-alterations-in-dolphins
#18
Eva Borras, Alexander A Aksenov, Mark Baird, Brittany Novick, Michael Schivo, Konstantin O Zamuruyev, Alberto Pasamontes, Celeste Parry, Soraya Foutouhi, Stephanie Venn-Watson, Bart C Weimer, Cristina E Davis
Monitoring health conditions is essential to detect early asymptomatic stages of a disease. To achieve this, blood, urine and breath samples are commonly used as a routine clinical diagnostic. These samples offer the opportunity to detect specific metabolites related to diseases and provide a better understanding of their development. Although blood samples are commonly used routinely to monitor health, the implementation of a relatively noninvasive technique, such as exhaled breath condensate (EBC) analysis, may further benefit the well-being of both humans and other animals...
October 23, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29042272/effects-of-dietary-nitrate-on-respiratory-physiology-at-high-altitude-results-from-the-xtreme-alps-study
#19
Andrew F Cumpstey, Philip J Hennis, Edward T Gilbert-Kawai, Bernadette O Fernandez, Matthieu Poudevigne, Alexandra Cobb, Paula Meale, Kay Mitchell, Helen Moyses, Helmut Pöhnl, Monty G Mythen, Michael P W Grocott, Martin Feelisch, Daniel S Martin
Nitric oxide (NO) production plays a central role in conferring tolerance to hypoxia. Tibetan highlanders, successful high-altitude dwellers for millennia, have higher circulating nitrate and exhaled NO (ENO) levels than native lowlanders. Since nitrate itself can reduce the oxygen cost of exercise in normoxia it may confer additional benefits at high altitude. Xtreme Alps was a double-blinded randomised placebo-controlled trial to investigate how dietary nitrate supplementation affects physiological responses to hypoxia in 28 healthy adult volunteers resident at 4559 m for 1 week; 14 receiving a beetroot-based high-nitrate supplement and 14 receiving a low-nitrate 'placebo' of matching appearance/taste...
December 1, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29034331/extensive-core-microbiome-in-drone-captured-whale-blow-supports-a-framework-for-health-monitoring
#20
Amy Apprill, Carolyn A Miller, Michael J Moore, John W Durban, Holly Fearnbach, Lance G Barrett-Lennard
The pulmonary system is a common site for bacterial infections in cetaceans, but very little is known about their respiratory microbiome. We used a small, unmanned hexacopter to collect exhaled breath condensate (blow) from two geographically distinct populations of apparently healthy humpback whales (Megaptera novaeangliae), sampled in the Massachusetts coastal waters off Cape Cod (n = 17) and coastal waters around Vancouver Island (n = 9). Bacterial and archaeal small-subunit rRNA genes were amplified and sequenced from blow samples, including many of sparse volume, as well as seawater and other controls, to characterize the associated microbial community...
September 2017: MSystems
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