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Exhaled breath condensate

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https://www.readbyqxmd.com/read/29104183/exhaled-breath-aerosol-eba-the-simplest-non-invasive-medium-for-public-health-and-occupational-exposure-biomonitoring
#1
Joachim D Pleil, Ariel Wallace, Michael C Madden
Exhaled breath collection has long been recognized as requiring the least invasive methods of the biological fluids and so is preferred for environmental and public health studies. This commentary describes how breath biomonitoring is generally preferred for certain logistical reasons in public health and occupational biomonitoring. Three different fractions of exhaled breath are considered: gas-phase, liquid condensate, and aerosols. The focus is on the exhaled breath aerosol (EBA) fraction and the development of targeted sampling and analysis methods...
November 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29098476/influence-of-air-pollution-on-airway-inflammation-and-disease-activity-in-childhood-systemic-lupus-erythematosus
#2
Andressa Guariento Ferreira Alves, Maria Fernanda de Azevedo Giacomin, Alfésio Luis Ferreira Braga, Adriana Maluf Elias Sallum, Luiz Alberto Amador Pereira, Luis Carlos Farhat, Fernando Louzada Strufaldi, Ana Julia de Faria Coimbra Lichtenfels, Tômas de Santana Carvalho, Naomi Kondo Nakagawa, Clovis Artur Silva, Sylvia Costa Lima Farhat
Exposure to fine particles may trigger pulmonary inflammation/systemic inflammation. The objective of this study was to investigate the association between daily individual exposure to air pollutants and airway inflammation and disease activity in childhood-onset systemic lupus erythematosus (cSLE) patients. A longitudinal panel study was carried out in 108 consecutive appointments with cSLE patients without respiratory diseases. Over four consecutive weeks, daily individual measures of nitrogen dioxide (NO2), fine particulate matter (PM2...
November 2, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29084127/green-coffee-been-exposure-and-symptoms-in-dock-workers-in-trieste-italy
#3
Anna Gasperazzo, Paolo Toffanin, Francesca Larese Filon
BACKGROUND: Green coffee workers can develop allergic symptoms due to green coffee beans (GCB) or to castor bean (CB) that can contaminate sacks used for the transportation. Data are limited in literature and a previous study performed in Trieste demonstrated allergic symptoms in 14.3% of dockworkers handling GCB. OBJECTIVES: To evaluate symptoms and exposure to GCB ultrafine particles in Trieste dockworkers. METHODS: Workers involved in GCB sacks transportation, storage and opening were asked to fill out a questionnaire on allergic respiratory symptoms...
October 27, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29083318/obstructive-sleep-apnea-patients-can-be-identified-by-ion-mobility-spectrometry-derived-smell-prints-of-different-biological-materials
#4
Timm Greulich, Hannes Fischer, Dirk Lubbe, Christoph Nell, Joerg Ingo Baumbach, Ulrich Koehler, Tobias Boeselt, Claus Vogelmeier, Andreas Koczulla
The analysis of sleep apnoea syndrome (OSAS) is time- and cost-intensive. A number of studies demonstrated that the non-invasive analysis of exhaled breath may be suitable to distinguish between OSAS patients and healthy subjects (HS). Methods/Population: We included OSAS patients (n=15) and HS (n=15) in this diagnostic proof-of-concept-study. All participants underwent polygraphy to verify or exclude OSAS and performed spirometry to exclude pulmonary ventilatory diseases. The VOC profile of exhaled breath and of the headspaces over exhaled breath condensate, pharyngeal washing fluid, and serum was measured using ion mobility spectrometry (BioScout®) and an e-nose (Cyranose® 320)...
October 30, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29078843/correlation-between-tumor-necrosis-factor-%C3%AE-and-interleukin-1%C3%AE-in-exhaled-breath-condensate-and-pulmonary-function
#5
Xuefeng Lin, Yichu Fan, Xiaodong Wang, Mingyou Chi, Xin Li, Xun Zhang, Daqiang Sun
BACKGROUND: Exhaled breath condensate (EBC) has emerged as a noninvasive method for assessing inflammation in lung diseases. Our aim is to investigate the correlation between tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) in EBC and in lung tissue, and between these values in EBC with pulmonary function tests in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: To ensure the availability of lung tissue, 60 patients undergoing resection for early lung cancer were divided into 3 groups: a COPD treatment group, a COPD control group and a non-COPD group...
October 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29063162/exhaled-breath-condensate-methods-adapted-from-human-studies-using-longitudinal-metabolomics-for-predicting-early-health-alterations-in-dolphins
#6
Eva Borras, Alexander A Aksenov, Mark Baird, Brittany Novick, Michael Schivo, Konstantin O Zamuruyev, Alberto Pasamontes, Celeste Parry, Soraya Foutouhi, Stephanie Venn-Watson, Bart C Weimer, Cristina E Davis
Monitoring health conditions is essential to detect early asymptomatic stages of a disease. To achieve this, blood, urine and breath samples are commonly used as a routine clinical diagnostic. These samples offer the opportunity to detect specific metabolites related to diseases and provide a better understanding of their development. Although blood samples are commonly used routinely to monitor health, the implementation of a relatively noninvasive technique, such as exhaled breath condensate (EBC) analysis, may further benefit the well-being of both humans and other animals...
October 23, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29042272/effects-of-dietary-nitrate-on-respiratory-physiology-at-high-altitude-results-from-the-xtreme-alps-study
#7
Andrew F Cumpstey, Philip J Hennis, Edward T Gilbert-Kawai, Bernadette O Fernandez, Matthieu Poudevigne, Alexandra Cobb, Paula Meale, Kay Mitchell, Helen Moyses, Helmut Pöhnl, Monty G Mythen, Michael P W Grocott, Martin Feelisch, Daniel S Martin
Nitric oxide (NO) production plays a central role in conferring tolerance to hypoxia. Tibetan highlanders, successful high-altitude dwellers for millennia, have higher circulating nitrate and exhaled NO (ENO) levels than native lowlanders. Since nitrate itself can reduce the oxygen cost of exercise in normoxia it may confer additional benefits at high altitude. Xtreme Alps was a double-blinded randomised placebo-controlled trial to investigate how dietary nitrate supplementation affects physiological responses to hypoxia in 28 healthy adult volunteers resident at 4559 m for 1 week; 14 receiving a beetroot-based high-nitrate supplement and 14 receiving a low-nitrate 'placebo' of matching appearance/taste...
October 16, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29034331/extensive-core-microbiome-in-drone-captured-whale-blow-supports-a-framework-for-health-monitoring
#8
Amy Apprill, Carolyn A Miller, Michael J Moore, John W Durban, Holly Fearnbach, Lance G Barrett-Lennard
The pulmonary system is a common site for bacterial infections in cetaceans, but very little is known about their respiratory microbiome. We used a small, unmanned hexacopter to collect exhaled breath condensate (blow) from two geographically distinct populations of apparently healthy humpback whales (Megaptera novaeangliae), sampled in the Massachusetts coastal waters off Cape Cod (n = 17) and coastal waters around Vancouver Island (n = 9). Bacterial and archaeal small-subunit rRNA genes were amplified and sequenced from blow samples, including many of sparse volume, as well as seawater and other controls, to characterize the associated microbial community...
September 2017: MSystems
https://www.readbyqxmd.com/read/28970160/aspergillus-galactomannan-detection-in-exhaled-breath-condensate-compared-to-bronchoalveolar-lavage-fluid-for-the-diagnosis-of-invasive-aspergillosis-in-immunocompromised-patients
#9
Alyajahan Bhimji, Archana Bhaskaran, Lianne G Singer, Deepali Kumar, Atul Humar, Rhea Pavan, Jeffrey Lipton, John Kuruvilla, Andre Schuh, Karen Yee, Mark D Minden, Aaron Schimmer, Coleman Rotstein, Shaf Keshavjee, Tony Mazzulli, Shahid Husain
OBJECTIVE: Exhaled breath condensate (EBC) is a noninvasive means of sampling the airways that has shown significant promise in the diagnosis of many disorders. There have been no reports of its utility for the detection of galactomannan (GM), a component of the cell wall of Aspergillus. The suitability of EBC for the detection of GM for the diagnosis of invasive aspergillosis (IA) using the Platelia(®)Aspergillus enzyme-linked immunosorbent assay (ELISA) was investigated. METHODS: Prospective, cross-sectional study of lung transplant recipient and hematological malignancy patients at a university center...
September 29, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28952460/serum-and-exhaled-breath-condensate-leptin-levels-in-asthmatic-and-obesity-children-a-pilot-study
#10
A Bodini, L Tenero, M Sandri, C Maffeis, M Piazza, L Zanoni, D Peroni, A Boner, G Piacentini
BACKGROUND: Recent studies have highlighted the possible involvement of leptin in inflammation. The leptin receptor is also expressed by alveolar macrophages, T lymphocytes and bronchial epitelial cells, suggesting a possible role in the cascade of airway inflammation. OBJECTIVES: The aim of the study was to evaluate the levels of leptin in exhaled breath condensate (EBC) from asthmatic, normal- and overweight children, in relationship with airway inflammation. METHODS: 15 asthmatic non-obese children, 15 healthy non-asthmatic non-obese children, 11 obese children with asthma (OA) and 20 obese children without asthma (ONA) were enrolled...
September 27, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28944471/a-composite-of-exhaled-ltb4-lxa4-feno-and-fev1-as-an-asthma-classification-ratio-characterizes-childhood-asthma
#11
Li-Chen Chen, Hsu-Min Tseng, Ming-Ling Kuo, Chih-Yung Chiu, Sui-Ling Liao, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Shen-Hao Lai, Tsung-Chieh Yao, Kuo-Wei Yeh, Ai-Hsuan Wu, Jing-Long Huang, Shau-Ku Huang
BACKGROUND: Aberrant generation of eicosanoids is associated with asthma, but the evidence remains incomplete and its potential utility as biomarkers is unclear. Major eicosanoids in exhaled breath condensates (EBCs) were assessed as candidate markers for childhood asthma. METHODS: Ten exhaled eicosanoid species was evaluated using ELISA in the discovery phase, followed by prediction model-building and validation phases. RESULTS: Exhaled LTB4 , LTE4 , PGE2 and LXA4 showed significant difference between asthmatics (N=60) and controls (N=20)...
September 25, 2017: Allergy
https://www.readbyqxmd.com/read/28911841/the-consistency-and-influence-of-environmental-and-animal-factors-on-exhaled-breath-condensate-hydrogen-peroxide-ph-and-leukotriene-b4-in-horses
#12
S du Preez, S L Raidal, G S Doran, S G Nielsen, K J Hughes
This study was performed to determine the consistency of exhaled breath condensate (EBC) hydrogen peroxide (H2O2), pH and leukotriene B4 (LTB4) measurements in asymptomatic horses and to define the influence of environmental and animal factors on these variables. Intra- and inter-day consistency for both H2O2 and pH measurements were adequate, with intraclass correlation coefficients ≥0.8, whereas the consistency for LTB4 was poor. H2O2 was influenced by ambient temperature (TA), humidity, time of day and collection location (all P<0...
August 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28894051/standardization-of-the-collection-of-exhaled-breath-condensate-and-exhaled-breath-aerosol-using-a-feedback-regulated-sampling-device
#13
Brett R Winters, Joachim D Pleil, Michelle M Angrish, Matthew A Stiegel, Terence H Risby, Michael C Madden
Exhaled breath condensate (EBC) and associated exhaled breath aerosols (EBA) are valuable non-invasive biological media used for the quantification of biomarkers. EBC contains exhaled water vapor, soluble gas-phase (polar) organic compounds, ionic species, plus other species including semi- and non-volatile organic compounds, proteins, cell fragments, DNA, dissolved inorganic compounds, ions, and micro-biota (bacteria and viruses) dissolved in the co-collected EBA. EBC is collected from subjects who breathe "normally" through a chilled tube assembly for approximately 10 minutes and is then harvested into small vials for analysis...
September 12, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28856884/mass-spectrometric-detection-of-omega-oxidation-products-of-aliphatic-fatty-acids-in-exhaled-breath
#14
Martin Thomas Gaugg, Tobias Bruderer, Nora Nowak, Lara Eiffert, Pablo Martinez-Lozano Sinues, Malcolm Kohler, Renato Zenobi
Omega-oxidation is a fatty acid degradation pathway that can occur alternatively to the dominant β-oxidation. The dysregulation of fatty acid oxidation has been related with a variety of diseases, termed fatty acid oxidation disorders. This work shows evidence for real-time detection in exhaled breath of the complete series of saturated linear ω-hydroxyalkanoic acids, ω-oxoalkanoic acids, and alkanedioic acids with carbon chain lengths of 5-15. We present a comprehensive analytical workflow using online and subsequent offline methods: secondary electrospray ionization mass spectrometry of exhaled breath and UHPLC-HRMS/MS experiments using exhaled breath condensate, respectively...
September 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28837903/the-association-of-e-cigarette-use-with-exposure-to-nickel-and-chromium-a-preliminary-study-of-non-invasive-biomarkers
#15
Angela Aherrera, Pablo Olmedo, Maria Grau-Perez, Stefan Tanda, Walter Goessler, Stephanie Jarmul, Rui Chen, Joanna E Cohen, Ana M Rule, Ana Navas-Acien
BACKGROUND: Nickel (Ni) and chromium (Cr) are components of e-cigarette heating coils. Whether e-cigarettes increase metal internal dose, however, is unknown. We assessed the association of e-cigarette use patterns and of e-liquid and aerosol metal concentrations with Ni and Cr biomarker levels in e-cigarette users from Maryland. METHODS: We recruited 64 e-cigarette users from December 2015 to March 2016. We collected urine, saliva, and exhaled breath condensate (EBC), data on e-cigarette use, and samples from their e-cigarette device (dispenser e-liquid, aerosol, and tank e-liquid)...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28822945/development-of-an-accurate-and-sensitive-method-for-lactate-analysis-in-exhaled-breath-condensate-by-lc-ms-ms
#16
Thomas C Jackson, Yan Victoria Zhang, Patricia J Sime, Richard P Phipps, R Matthew Kottmann
Exhaled breath condensate (EBC) is easily obtained for clinical diagnosis and prognosis for pulmonary diseases and has gained much interest in biomarker discovery research and studies. Lactate, a physiological material, is found in EBC and has been demonstrated to be a potential indicator of chronic obstructive pulmonary disease and other lung diseases. Several assays are available to detect lactate in human body fluids, and yet none is suitable for detecting lactate in EBC. Due to the very low concentration of lactate in EBC and low volume of EBC, it is very important to develop an assay to measure lactate with high sensitivity, accuracy and easy sample processing...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28822267/a-similar-pro-anti-inflammatory-cytokine-balance-is-present-in-the-airways-of-competitive-athletes-and-non-exercising-asthmatics
#17
Marcin Kurowski, Janusz Jurczyk, Agnieszka Olszewska-Ziąber, Marzanna Jarzębska, Hubert Krysztofiak, Marek L Kowalski
PURPOSE: Intensive exercise modifies airway inflammation and infection susceptibility. We aimed to determine the effect of exercise on pro- and anti-inflammatory cytokine (TNF-α, IL-1ra, IL-10) and innate immunity protein (HSPA1, sCD14) levels in exhaled breath condensate (EBC) and nasal secretions of competitive athletes, non-exercising asthmatics and healthy controls (HC). MATERIAL AND METHODS: The study group consisted of 15 competitive athletes (five speed skaters and ten swimmers) aged 15-25...
August 16, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28810688/exhaled-breath-condensate-a-novel-matrix-for-biological-monitoring-to-assess-occupational-exposure-to-respirable-crystalline-silica
#18
Elizabeth Leese, James F Staff, Vikki A Carolan, Jackie Morton
Biological monitoring (BM) is a useful way of determining overall exposures to chemical substances; however, in the case of respirable crystalline silica (RCS), this has not been analytically feasible in conventional biological matrices. The aim of this study was to investigate the utility of exhaled breath condensate (EBC) as a potential biological matrix in which to determine exposure to RCS. A small pilot study was undertaken collecting EBC from six quarry workers and six occupationally unexposed persons; the samples were analysed using both single particle inductively coupled plasma mass spectrometry (spICP-MS) and transmission electron microscopy (TEM)...
August 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28808178/metabolomic-profiles-of-plasma-exhaled-breath-condensate-and-saliva-are-correlated-with-potential-for-air-toxics-detection
#19
Chandresh Nanji Ladva, Rachel Golan, Roby Greenwald, Tianwei Yu, Stefanie Ebelt Sarnat, W Dana Flanders, Karan Uppal, Douglas I Walker, ViLinh Tran, Donghai Liang, Dean P Jones, Jeremy Sarnat
Advances in the development of high-resolution metabolomics (HRM) have provided new opportunities for their use in characterizing exposures to environmental air pollutants and air pollution-related disease etiologies. Exposure assessment studies have considered blood, breath, and saliva as biological matrices suitable for measuring responses to air pollution exposures. The current study examines comparability among these three matrices using HRM and explored their potential for measuring mobile source air toxics...
August 15, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28792066/advances-in-the-analysis-of-less-conventional-human-body-fluids-an-overview-of-the-ce-and-hplc-ms-applications-in-the-years-2015-2017
#20
REVIEW
Monica Di Venere, Simona Viglio, Maddalena Cagnone, Anna Bardoni, Roberta Salvini, Paolo Iadarola
Aim of this article is to focus the attention of the reader on the application of CE/MS and LC/MS to the analysis of human body fluids not currently used for the diagnosis of disorders and, for this reason, catalogued as "less/nonconventional" fluids, that is, tears, nasal secretions, cerumen, bronchoalveolar lavage fluid, sputum, exhaled breath condensate, nipple aspirate, breast milk, amniotic fluid, bile, seminal plasma, liposuction aspirate fluid, and synovial fluid. The pool of articles presented in this report demonstrates that, rather than being neglected, these fluids are an important resource for the evaluation of possible pathologic conditions...
August 9, 2017: Electrophoresis
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