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Exhaled breath condensate

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https://www.readbyqxmd.com/read/29776545/evolution-of-clinical-and-environmental-health-applications-of-exhaled-breath-research-review-of-methods-and-instrumentation-for-gas-phase-condensate-and-aerosols
#1
REVIEW
M Ariel Geer Wallace, Joachim D Pleil
Human breath, along with urine and blood, has long been one of the three major biological media for assessing human health and environmental exposure. In fact, the detection of odor on human breath, as described by Hippocrates in 400 BC, is considered the first analytical health assessment tool. Although less common in comparison to contemporary bio-fluids analyses, breath has become an attractive diagnostic medium as sampling is non-invasive, unlimited in timing and volume, and does not require clinical personnel...
September 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29771240/power-efficient-self-cleaning-hydrophilic-condenser-surface-for-portable-exhaled-breath-condensate-ebc-metabolomic-sampling
#2
Konstantin O Zamuruyev, Alexander James Schmidt, Eva Borras, Mitchell M McCartney, Michael Schivo, Nicholas J Kenyon, Jean-Pierre Delplanque, Cristina E Davis
In this work, we present a hydrophilic self-cleaning condenser surface for collection of biological and environmental aerosol samples. The condenser is installed in a battery-operated, hand-held breath sampling device. The device performance is characterized with collection and analysis of exhaled breath samples from a group of volunteers. The exhaled breath condensate is collected on a sub-cooled condenser surface, transferred into a storage vial, and its chemical content is analyzed with mass spectrometric methods...
May 17, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29752619/a-feasibility-study-into-adenosine-triphosphate-measurement-in-exhaled-breath-condensate-a-potential-bedside-method-to-monitor-alveolar-deformation
#3
Philip van der Zee, Peter Somhorst, Jeroen Molinger, Djo Hasan, Diederik Gommers
Recent research suggested an important role for pulmonary extracellular adenosine triphosphate (ATP) in the development of ventilation-induced lung injury. This injury is induced by mechanical deformation of alveolar epithelial cells, which in turn release ATP to the extracellular space. Measuring extracellular ATP in exhaled breath condensate (EBC) may be a non-invasive biomarker for alveolar deformation. Here, we study the feasibility of bedside ATP measurement in EBC. We measured ATP levels in EBC in ten subjects before and after an exercise test, which increases respiratory parameters and alveolar deformation...
May 12, 2018: Purinergic Signalling
https://www.readbyqxmd.com/read/29751135/brief-report-on-the-detection-of-the-egfr-t790m-mutation-in-exhaled-breath-condensate-from-lung-cancer-patients
#4
Robert J Smyth, Sinead M Toomey, Alexander Sartori, Emer O Hanrahan, Sinead D Cuffe, Oscar S Breathnach, Ross K Morgan, Bryan T Hennessy
The EGFR-T790M somatic mutation is the most common mechanism of resistance to Tyrosine Kinase Inhibitors (TKI) in non-small cell lung cancer. Patients with advanced disease are not always amenable to repeat biopsy for further molecular analysis. Developing non-invasive methods to detect T790M in cell-free DNA (cfDNA), in the absence of tissue is being actively investigated. Unfortunately the low sensitivity of plasma for T790M detection has limited its clinical use. Exhaled breath condensate (EBC) is an easily collected sample, known to harbour cfDNA, including lung cancer mutations...
May 8, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29724959/new-breath-related-topics-sample-collection-for-exhaled-breath-condensate-and-aerosol-development-of-real-time-medical-alerts-measurement-of-artificial-atmospheres-and-analysis-of-legalized-cannabis-product
#5
Joachim D Pleil, Ariel Wallace
Exhaled breath technology is expanding beyond conventional gas-phase analysis, and conversely, methodology from other disciplines is finding applications in breath research. Recently, the authors attended conferences that incorporated new technologies into "breath related" applications. The first was the International Submarine Air Monitoring and Air Purification (SAMAP) held in Uncasville Connecticut, November 2017, and the second was the Pittcon Conference and Exposition (Pittcon) held in Orlando Florida, February 2018...
May 4, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29719507/breathomics-for-assessing-the-effects-of-treatment-and-withdrawal-with-inhaled-beclomethasone-formoterol-in-patients-with-copd
#6
Paolo Montuschi, Giuseppe Santini, Nadia Mores, Alessia Vignoli, Francesco Macagno, Rugia Shoreh, Leonardo Tenori, Gina Zini, Leonello Fuso, Chiara Mondino, Corrado Di Natale, Arnaldo D'Amico, Claudio Luchinat, Peter J Barnes, Tim Higenbottam
Background: Prospective pharmacological studies on breathomics profiles in COPD patients have not been previously reported. We assessed the effects of treatment and withdrawal of an extrafine inhaled corticosteroid (ICS)-long-acting β2 -agonist (LABA) fixed dose combination (FDC) using a multidimensional classification model including breathomics. Methods: A pilot, proof-of-concept, pharmacological study was undertaken in 14 COPD patients on maintenance treatment with inhaled fluticasone propionate/salmeterol (500/50 μg b...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29719222/biomarkers-of-exposure-to-stainless-steel-tungsten-inert-gas-welding-fumes-and-the-effect-of-exposure-on-exhaled-breath-condensate
#7
Maria Grazia Riccelli, Matteo Goldoni, Roberta Andreoli, Paola Mozzoni, Silvana Pinelli, Rossella Alinovi, Luisella Selis, Antonio Mutti, Massimo Corradi
The respiratory tract is the main target organ of the inhaled hexavalent chromium (Cr-VI) and nickel (Ni) contained in stainless steel (SS) welding fumes (WFs). The aim of this study was to investigate the Cr and Ni content of the exhaled breath condensate (EBC) of SS tungsten inert gas (TIG) welders, and relate their concentrations with oxidative stress and inflammatory biomarkers. EBC and urine from 100 SS TIG welders were collected pre-(T0 ) and post-shift (T1 ) on a Friday, and pre-shift (T2 ) on the following Monday morning...
April 29, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29680435/comparison-of-two-exhaled-biomarkers-in-children-with-and-without-sleep-disordered-breathing
#8
Mario Barreto, Paolo Montuschi, Melania Evangelisti, Susanna Bonafoni, Manuela Cecili, Rugia Shohreh, Giuseppe Santini, Maria Pia Villa
OBJECTIVE: Airway oxidative stress and inflammation are likely to be involved in sleep disordered breathing (SDB) in children. We aimed to measure concentrations of 8-isoprostane (8-IsoP) in the exhaled breath condensate (EBC) and exhaled nitric oxide (FENO ) in patients with SBD and healthy children, in order to assess the relationship between these two biomarkers, disease severity, and overnight changes. METHODS: Patients with SDB (n = 46) and healthy controls (n = 20) aged 4...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29658165/electrochemical-monitoring-of-malondialdehyde-biomarker-in-biological-samples-via-electropolymerized-amino-acid-chitosan-nanocomposite
#9
Mohammad Hasanzadeh, Fozieh Mokhtari, Vahid Jouyban-Gharamaleki, Ahad Mokhtarzadeh, Nasrin Shadjou
This study reports on the electropolymerization of a low toxic and biocompatible nanopolymer with entitle poly arginine-graphene quantum dots-chitosan (PARG-GQDs-CS) as a novel strategy for surface modification of glassy carbon surface and preparation of a new interface for measurement of malondialdehyde (MDA) in exhaled breath condensate. Electrochemical deposition, as a well-controlled synthesis procedure, has been used for subsequently layer-by-layer preparation of GQDs-CS nanostructures on a PARG prepolymerized on the surface of glassy carbon electrode using cyclic voltammetry techniques in the regime of -1...
April 15, 2018: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29651988/evaluation-of-a-new-method-for-the-collection-and-measurement-of-8-isoprostane-in-exhaled-breath-for-future-application-in-nanoparticle-exposure-biomonitoring
#10
Caroline Marie-Desvergne, Muriel Dubosson, Véronique Chamel Mossuz
Background
 In the field of nanoparticle exposure biomonitoring, oxidative stress biomarkers measured in exhaled breath condensate appear promising to detect early respiratory effects in workers handling nanomaterials. However, condensation is known for its poor efficiency in collecting non-volatiles in exhaled breath, leading to the low sensitivity of such measurements. Moreover, to be easily used in field studies on large groups of workers, the collection device must be disposable and convenient.
 Objectives
 In this study, we have tested a totally disposable commercial device that allows for the easy dry collection of exhaled air after filtration on a patented filter...
April 13, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29614540/-ct-screening-for-lung-cancer-what-is-the-evidence
#11
Iris Watermann, Martin Reck
In patients with lung cancer treatment opportunities and prognosis are correlated to the stage of disease with a chance for curative treatment in patients with early stage disease. Therefore, early detection of lung cancer is of paramount importance for improving the prognosis of lung cancer patients.The National Lung Screening Trial (NLST) has already shown that low-dose CT increases the number of identified early stage lung cancer patients and reduces lung cancer related mortality. Critically considered in terms of CT-screening are false-positive results, overdiagnosis and unessential invasive clarification...
April 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29605196/exhaled-breath-nox-levels-in-a-middle-aged-adults-population-based-study-reference-values-and-association-with-the-smoking-status
#12
Nathalie Chérot-Kornobis, Sébastien Hulo, Jonathan Giovannelli, Virginie de Broucker, Régis Matran, Philippe Amouyel, Annie Sobaszek, Luc Dauchet, Jean-Louis Edmé
BACKGROUND: Biomarkers in exhaled breath condensate (EBC) are potentially sensitive indicators of early biochemical changes in airways following exposure to pneumotoxic substances, particularly in susceptible subjects. NOx are the stable end products of the nitrite-nitrate-NO oxidative stress pathway and can be used to monitor airway inflammatory diseases, especially in asthma. Nevertheless, population-based surveys are needed to better interpret EBC NOx levels in clinical studies. The aim of this study was to establish reference values of EBC NOx in a large group of middle-aged, healthy adults of a sample of the general population with particular focus on the smoking status...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29566971/the-mega-project-a-study-of-the-mechanisms-involved-in-the-genesis-and-disease-course-of-asthma-asthma-cohort-creation-and-long-term-follow-up
#13
Xavier Muñoz, María José Álvarez-Puebla, Ebymar Arismendi, Lourdes Arochena, María Del Pilar Ausín, Pilar Barranco, Irina Bobolea, Jose Antonio Cañas, Blanca Cardaba, Astrid Crespo, Victora Del Pozo, Javier Domínguez-Ortega, María Del Mar Fernandez-Nieto, Jordi Giner, Francisco Javier González-Barcala, Juan Alberto Luna, Joaquim Mullol, Iñigo Ojanguren, José María Olaguibel, César Picado, Vicente Plaza, Santiago Quirce, David Ramos, Manuel Rial, Christian Romero-Mesones, Francisco Javier Salgado, María Esther San-José, Silvia Sánchez-Diez, Beatriz Sastre, Joaquin Sastre, Lorena Soto, Montserrat Torrejón, Marisa Urnadoz, Luis Valdes, Antonio Valero, María Jesús Cruz
The general aim of this study is to create a cohort of asthma patients with varying grades of severity in order to gain greater insight into the mechanisms underlying the genesis and course of this disease. The specific objectives focus on various studies, including imaging, lung function, inflammation, and bronchial hyperresponsiveness, to determine the relevant events that characterize the asthma population, the long-term parameters that can determine changes in the severity of patients, and the treatments that influence disease progression...
March 19, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29495451/phenotyping-of-chronic-obstructive-pulmonary-disease-based-on-the-integration-of-metabolomes-and-clinical-characteristics
#14
Kalle Kilk, Argo Aug, Aigar Ottas, Ursel Soomets, Siiri Altraja, Alan Altraja
Apart from the refined management-oriented clinical stratification of chronic obstructive pulmonary disease (COPD), the molecular pathologies behind this highly prevalent disease have remained obscure. The aim of this study was the characterization of patients with COPD, based on the metabolomic profiling of peripheral blood and exhaled breath condensate (EBC) within the context of defined clinical and demographic variables. Mass-spectrometry-based targeted analysis of serum metabolites (mainly amino acids and lipid species), untargeted profiles of serum and EBC of patients with COPD of different clinical characteristics ( n = 25) and control individuals ( n = 21) were performed...
February 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29490415/concentration-of-8-isoprostanes-in-the-exhaled-breath-condensate-as-a-marker-of-oxidative-stress-in-patients-with-type-1-diabetes
#15
Anna Pękala-Wojciechowska, Michał Poznański, Kamil Szyszow, Adam Antczak
INTRODUCTION: Type 1 diabetes is an insulin deficiency-based chronic disease. It leads to the development of hyperglycaemia, which plays a key role in the initiation and progression of tissue damage in patients with diabetes. This mostly results from oxidative stress, whose increased severity is observed in this group of patients. Increased levels of 8-isoprostanes are seen in many inflammatory diseases, including asthma, COPD and cystic fibrosis. These diseases demonstrated the usefulness of the exhaled breath condensate (EBC) for extracting material for markers of oxidative stress, including 8-isoprostanes...
2018: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29477235/bioanalysis-of-underivatized-amino-acids-in-non-invasive-exhaled-breath-condensate-samples-using-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#16
Lucyna Konieczna, Magdalena Pyszka, Magdalena Okońska, Maciej Niedźwiecki, Tomasz Bączek
Exhaled breath condensate (EBC) is receiving increased attention as a novel, entirely non-invasive technique for collecting biomarker samples. This increased attention is due to the fact that EBC is simple, effort independent, rapid, can be repeated frequently, and can be performed on young children and patients suffering from a variety of diseases. By having a subject breathe tidally through a cooling system for 15-20 min, a sufficient amount of condensate is collected for analysis of biomarkers in clinical studies...
March 23, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29461276/health-surveillance-for-occupational-asthma
#17
David Fishwick, Steve Forman
PURPOSE OF REVIEW: The outcome for workers with occupational asthma is improved for those with an earlier diagnosis. Health surveillance at work is in principle designed to identify such cases, so that the risks to the individual worker, and coworkers, can be reduced. There is recent evidence to suggest that the uptake and quality of such surveillance could be improved. This review has assessed current approaches to health surveillance for occupational asthma. RECENT FINDINGS: The article covers a review of the utility of questionnaires, lung function testing, immunological investigations, and other tests, including exhaled nitric oxide, sputum eosinophilia, and exhaled breath condensate specifically in the context of workplace-based health surveillance...
April 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29443104/absorption-of-nasal-and-bronchial-fluids-precision-sampling-of-the-human-respiratory-mucosa-and-laboratory-processing-of-samples
#18
Ryan S Thwaites, Hannah C Jarvis, Nehmat Singh, Akhilesh Jha, Andy Pritchard, Hailing Fan, Tanushree Tunstall, Joan Nanan, Simon Nadel, Onn Min Kon, Peter J Openshaw, Trevor T Hansel
The methods of nasal absorption (NA) and bronchial absorption (BA) use synthetic absorptive matrices (SAM) to absorb the mucosal lining fluid (MLF) of the human respiratory tract. NA is a non-invasive technique which absorbs fluid from the inferior turbinate, and causes minimal discomfort. NA has yielded reproducible results with the ability to frequently repeat sampling of the upper airway. By comparison, alternative methods of sampling the respiratory mucosa, such as nasopharyngeal aspiration (NPA) and conventional swabbing, are more invasive and may result in greater data variability...
January 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29384875/electret-filter-collects-more-exhaled-albumin-than-glass-condenser-a-method-comparison-based-on-human-study
#19
COMPARATIVE STUDY
Ziru Jia, Hongying Liu, Wang Li, Dandan Xie, Ke Cheng, Xitian Pi
In recent years, noninvasive diagnosis based on biomarkers in exhaled breath has been extensively studied. The procedure of biomarker collection is a key step. However, the traditional condenser method has low efficacy in collecting nonvolatile compounds especially the protein biomarkers in breath. To solve this deficiency, here we propose an electret filter method.Exhaled breath of 6 volunteers was collected with a glass condenser and an electret filter. The amount of albumin was analyzed. Furthermore, the difference of exhaled albumin between smokers and nonsmokers was evaluated...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29382628/using-the-inflammacheck-device-to-measure-the-level-of-exhaled-breath-condensate-hydrogen-peroxide-in-patients-with-asthma-and-chronic-obstructive-pulmonary-disease-the-exhale-pilot-study-protocol-for-a-cross-sectional-feasibility-study
#20
Daniel M Neville, Carole Fogg, Thomas P Brown, Thomas L Jones, Eleanor Lanning, Paul Bassett, Anoop J Chauhan
BACKGROUND: Asthma and Chronic Obstructive Pulmonary Disease (COPD) are common conditions that affect over 5 million people in the United Kingdom. These groups of patients suffer significantly from breathlessness and recurrent exacerbations that can be difficult to diagnose and go untreated. A common feature of COPD and asthma is airway inflammation that increases before and during exacerbations. Current methods of assessing airway inflammation can be invasive, difficult to perform, and are often inaccurate...
January 30, 2018: JMIR Research Protocols
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