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Exhaled breath condensate

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https://www.readbyqxmd.com/read/28911841/the-consistency-and-influence-of-environmental-and-animal-factors-on-exhaled-breath-condensate-hydrogen-peroxide-ph-and-leukotriene-b4-in-horses
#1
S du Preez, S L Raidal, G S Doran, S G Nielsen, K J Hughes
This study was performed to determine the consistency of exhaled breath condensate (EBC) hydrogen peroxide (H2O2), pH and leukotriene B4 (LTB4) measurements in asymptomatic horses and to define the influence of environmental and animal factors on these variables. Intra- and inter-day consistency for both H2O2 and pH measurements were adequate, with intraclass correlation coefficients ≥0.8, whereas the consistency for LTB4 was poor. H2O2 was influenced by ambient temperature (TA), humidity, time of day and collection location (all P<0...
August 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28894051/standardization-of-the-collection-of-exhaled-breath-condensate-and-exhaled-breath-aerosol-using-a-feedback-regulated-sampling-device
#2
Brett R Winters, Joachim D Pleil, Michelle M Angrish, Matthew A Stiegel, Terence H Risby, Michael C Madden
Exhaled breath condensate (EBC) and associated exhaled breath aerosols (EBA) are valuable non-invasive biological media used for the quantification of biomarkers. EBC contains exhaled water vapor, soluble gas-phase (polar) organic compounds, ionic species, plus other species including semi- and non-volatile organic compounds, proteins, cell fragments, DNA, dissolved inorganic compounds, ions, and micro-biota (bacteria and viruses) dissolved in the co-collected EBA. EBC is collected from subjects who breathe "normally" through a chilled tube assembly for approximately 10 minutes and is then harvested into small vials for analysis...
September 12, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28856884/mass-spectrometric-detection-of-omega-oxidation-products-of-aliphatic-fatty-acids-in-exhaled-breath
#3
Martin Thomas Gaugg, Tobias Bruderer, Nora Nowak, Lara Eiffert, Pablo Martinez-Lozano Sinues, Malcolm Kohler, Renato Zenobi
Omega-oxidation is a fatty acid degradation pathway that can occur alternatively to the dominant β oxidation. The dysregulation of fatty acid oxidation has been related with a variety of diseases, termed fatty acid oxidation disorders. This work shows evidence for real-time detection in exhaled breath of the complete series of saturated linear ω hydroxyalkanoic acids, ω-oxoalkanoic acids and alkanedioic acids with carbon chain lengths of 5 15. We present a comprehensive analytical workflow using on-line and subsequent off-line methods: secondary electrospray ionization mass spectrometry of exhaled breath and UHPLC-HRMS/MS experiments using exhaled breath condensate, respectively...
August 31, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28837903/the-association-of-e-cigarette-use-with-exposure-to-nickel-and-chromium-a-preliminary-study-of-non-invasive-biomarkers
#4
Angela Aherrera, Pablo Olmedo, Maria Grau-Perez, Stefan Tanda, Walter Goessler, Stephanie Jarmul, Rui Chen, Joanna E Cohen, Ana M Rule, Ana Navas-Acien
BACKGROUND: Nickel (Ni) and chromium (Cr) are components of e-cigarette heating coils. Whether e-cigarettes increase metal internal dose, however, is unknown. We assessed the association of e-cigarette use patterns and of e-liquid and aerosol metal concentrations with Ni and Cr biomarker levels in e-cigarette users from Maryland. METHODS: We recruited 64 e-cigarette users from December 2015 to March 2016. We collected urine, saliva, and exhaled breath condensate (EBC), data on e-cigarette use, and samples from their e-cigarette device (dispenser e-liquid, aerosol, and tank e-liquid)...
August 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28822945/development-of-an-accurate-and-sensitive-method-for-lactate-analysis-in-exhaled-breath-condensate-by-lc-ms-ms
#5
Thomas C Jackson, Yan Victoria Zhang, Patricia J Sime, Richard P Phipps, R Matthew Kottmann
Exhaled breath condensate (EBC) is easily obtained for clinical diagnosis and prognosis for pulmonary diseases and has gained much interest in biomarker discovery research and studies. Lactate, a physiological material, is found in EBC and has been demonstrated to be a potential indicator of chronic obstructive pulmonary disease and other lung diseases. Several assays are available to detect lactate in human body fluids, and yet none is suitable for detecting lactate in EBC. Due to the very low concentration of lactate in EBC and low volume of EBC, it is very important to develop an assay to measure lactate with high sensitivity, accuracy and easy sample processing...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28822267/a-similar-pro-anti-inflammatory-cytokine-balance-is-present-in-the-airways-of-competitive-athletes-and-non-exercising-asthmatics
#6
Marcin Kurowski, Janusz Jurczyk, Agnieszka Olszewska-Ziąber, Marzanna Jarzębska, Hubert Krysztofiak, Marek L Kowalski
PURPOSE: Intensive exercise modifies airway inflammation and infection susceptibility. We aimed to determine the effect of exercise on pro- and anti-inflammatory cytokine (TNF-α, IL-1ra, IL-10) and innate immunity protein (HSPA1, sCD14) levels in exhaled breath condensate (EBC) and nasal secretions of competitive athletes, non-exercising asthmatics and healthy controls (HC). MATERIAL AND METHODS: The study group consisted of 15 competitive athletes (five speed skaters and ten swimmers) aged 15-25...
August 16, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28810688/exhaled-breath-condensate-a-novel-matrix-for-biological-monitoring-to-assess-occupational-exposure-to-respirable-crystalline-silica
#7
Elizabeth Leese, James F Staff, Vikki A Carolan, Jackie Morton
Biological monitoring (BM) is a useful way of determining overall exposures to chemical substances; however, in the case of respirable crystalline silica (RCS), this has not been analytically feasible in conventional biological matrices. The aim of this study was to investigate the utility of exhaled breath condensate (EBC) as a potential biological matrix in which to determine exposure to RCS. A small pilot study was undertaken collecting EBC from six quarry workers and six occupationally unexposed persons; the samples were analysed using both single particle inductively coupled plasma mass spectrometry (spICP-MS) and transmission electron microscopy (TEM)...
August 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28808178/metabolomic-profiles-of-plasma-exhaled-breath-condensate-and-saliva-are-correlated-with-potential-for-air-toxics-detection
#8
Chandresh Nanji Ladva, Rachel Golan, Roby Greenwald, Tianwei Yu, Stefanie Ebelt Sarnat, W Dana Flanders, Karan Uppal, Douglas I Walker, ViLinh Tran, Donghai Liang, Dean P Jones, Jeremy Sarnat
Advances in the development of high-resolution metabolomics (HRM) have provided new opportunities for their use in characterizing exposures to environmental air pollutants and air pollution-related disease etiologies. Exposure assessment studies have considered blood, breath, and saliva as biological matrices suitable for measuring responses to air pollution exposures. The current study examines comparability among these three matrices using HRM and explored their potential for measuring mobile source air toxics...
August 15, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28792066/advances-in-the-analysis-of-less-conventional-human-body-fluids-an-overview-of-the-ce-and-hplc-ms-applications-in-the-years-2015-2017
#9
REVIEW
Monica Di Venere, Simona Viglio, Maddalena Cagnone, Anna Bardoni, Roberta Salvini, Paolo Iadarola
Aim of this article is to focus the attention of the reader on the application of CE/MS and LC/MS to the analysis of human body fluids not currently used for the diagnosis of disorders and, for this reason, catalogued as "less/nonconventional" fluids, that is, tears, nasal secretions, cerumen, bronchoalveolar lavage fluid, sputum, exhaled breath condensate, nipple aspirate, breast milk, amniotic fluid, bile, seminal plasma, liposuction aspirate fluid, and synovial fluid. The pool of articles presented in this report demonstrates that, rather than being neglected, these fluids are an important resource for the evaluation of possible pathologic conditions...
August 9, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28791362/correlation-analysis-of-surfactant-protein-a-and-surfactant-protein-d-with-lung-function-in-exhaled-breath-condensate-from-lung-cancer-patients-with-and-without-copd
#10
Xuefeng Lin, Zhenlin Wu, Yichu Fan, Mingyou Chi, Xiaodong Wang, Xun Zhang, Daqiang Sun
Pulmonary surfactant protein A (SP‑A) and pulmonary surfactant protein D (SP‑D) are associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of the present study was to determine the correlation between SP‑A, SP‑D and lung function in patients with COPD. A total of 60 patients with lung cancer undergoing unilateral lobectomy were selected and divided into three groups, including a non‑COPD group (n=20), a COPD treatment group (n=20) and a COPD control group (n=20)...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28775244/exhaled-breath-condensate-as-a-potential-biomarker-tool-for-idiopathic-pulmonary-fibrosis-a-pilot-study
#11
Barbara Rindlisbacher, Carina Strebel, Sabina A Guler, Attila Kollar, Thomas K Geiser, Georg Martin Fiedler, Alexander Benedikt Leichtle, Cedric Bovet, Manuela Funke
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor survival. There is an urgent need to better diagnose and monitor IPF patients as new treatments are now available which slow down disease progression. Exhaled breath condensate (EBC) is easily and non-invasively collected, but analysis of potential biomarkers is difficult due to low concentrations and methodological limitations. We now used a non-targeted metabolomics approach to identify further discriminatory metabolic profiles that distinguish IPF patients from controls...
August 4, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28763131/the-effect-of-allergen-induced-bronchoconstriction-on-concentration-of-5-oxo-ete-in-exhaled-breath-condensate-of-house-dust-mite-allergic-patients
#12
Krzysztof Kowal, Anna Gielicz, Marek Sanak
BACKGROUND: Arachidonic acid metabolites regulate several aspects of airway function including inflammation, muscle contraction and mucous secretion. OBJECTIVE: The aim of this study was to evaluate concentration of selected 5-lipoxygenase (LOX) and cyclooxygenase (COX)-derived eicosanoids in exhaled breath condensate (EBC) during allergen induced bronchoconstriction. METHODS: The study was performed on 24 allergic rhinitis/asthma patients sensitized to a house dust mite (HDM) Dermatophagoides pteronyssinus (Dp) and 13 healthy controls (HCs)...
August 1, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28752074/co-liquefaction-with-acetone-and-gc-analysis-of-volatile-compounds-in-exhaled-breath-as-lung-cancer-biomarkers
#13
Abolghasem Jouyban, Djavanshir Djozan, Parastou Mohammadandashti, Aliakbar Alizadeh-Nabil, Hooshangh Ghorbanpour, Maryam Khoubnasabjafari, Mohammad Mohammadzadeh
Introduction: A simple, rapid and low cost method for enrichment of volatile organic compounds (VOCs) from exhaled breath (EB) is presented. Methods: A 1000 mL home-made extraction device was filled with EB. The VOCs were extracted and condensed in 0.5 mL acetone. Recognition of volatiles in the real studied EB samples was performed by a GC-MS. Results: The method displays an extraction efficiency of >86% with the enrichment factor of 1929 for octanal. Limits of detection and quantification, and linear dynamic range were 0...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28715576/association-of-ozone-exposure-with-cardiorespiratory-pathophysiologic-mechanisms-in-healthy-adults
#14
Drew B Day, Jianbang Xiang, Jinhan Mo, Feng Li, Mingkei Chung, Jicheng Gong, Charles J Weschler, Pamela A Ohman-Strickland, Jan Sundell, Wenguo Weng, Yinping Zhang, Junfeng Jim Zhang
Importance: Exposure to ozone has been associated with cardiovascular mortality, but the underlying biological mechanisms are not yet understood. Objective: To examine the association between ozone exposure and cardiopulmonary pathophysiologic mechanisms. Design, Setting, and Participants: A longitudinal study involving 89 healthy adult participants living on a work campus in Changsha City, China, was conducted from December 1, 2014, to January 31, 2015...
September 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28701890/relationship-between-oxidative-stress-physical-activity-and-vitamin-intake-in-patients-with-asthma
#15
Akira Yamasaki, Yuji Kawasaki, Kenichi Takeda, Tomoya Harada, Yasuyuki Hasegawa, Takehito Fukushima, Ryota Okazaki, Haruhiko Makino, Yoshihiro Funaki, Yuriko Sueda, Akihiro Yamamoto, Jun Kurai, Masanari Watanabe, Eiji Shimizu
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of bronchial asthma. Antioxidant nutrition and supplementation have been used to reduce oxidative stress. However, a clinical trial with antioxidant supplementation showed no beneficial effects in patients with asthma. On the other hand, physical activity is related to the prognosis of chronic obstructive pulmonary disease (COPD) and is also related to oxidant status. We investigated the relationships between oxidative stress, serum levels of vitamins, dietary vitamin intake, daily activities, and pulmonary functions in patients with asthma...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28697414/analytical-methodologies-for-broad-metabolite-coverage-of-exhaled-breath-condensate
#16
Alexander A Aksenov, Konstantin O Zamuruyev, Alberto Pasamontes, Joshua F Brown, Michael Schivo, Soraya Foutouhi, Bart C Weimer, Nicholas J Kenyon, Cristina E Davis
Breath analysis has been gaining popularity as a non-invasive technique that is amenable to a broad range of medical uses. One of the persistent problems hampering the wide application of the breath analysis method is measurement variability of metabolite abundances stemming from differences in both sampling and analysis methodologies used in various studies. Mass spectrometry has been a method of choice for comprehensive metabolomic analysis. For the first time in the present study, we juxtapose the most commonly employed mass spectrometry-based analysis methodologies and directly compare the resultant coverages of detected compounds in exhaled breath condensate in order to guide methodology choices for exhaled breath condensate analysis studies...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28660856/innovative-exhaled-breath-analysis-with-old-breathing-manoeuvres-is-there-a-problem-or-an-advantage
#17
Marieann Högman
As the field of exhaled breath research is expanding, the question that arises is can the old usual method of spirometry be used in all cases? The answer is yes for some analysation methods and definitely not for others: it all depends on the result you are looking for. Exhaled breath condensate collection can be accomplished with silent tidal breathing, but not in the analysation of the amount of exhaled particles, as they become very low during tidal breathing. There are gases that are exhalation flow dependent, e...
June 29, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28634021/mycoplasma-pneumoniae-and-health-outcomes-in-children-with-asthma
#18
Pamela R Wood, Jordan C Kampschmidt, Peter H Dube, Marianna P Cagle, Paola Chaparro, Norma S Ketchum, Thirumalai R Kannan, Harjinder Singh, Jay I Peters, Joel B Baseman, Edward G Brooks
BACKGROUND: Acute infections with Mycoplasma pneumoniae (Mp) have been associated with worsening asthma in children. Mp can be present in the respiratory tract for extended periods; it is unknown whether the long-term persistence of Mp in the respiratory tract affects long-term asthma control. OBJECTIVE: To determine the effect of Mp on asthma control. METHODS: We enrolled 31 pediatric subjects 3 to 10 years of age with persistent asthma who completed up to 8 visits over a 24-month period...
August 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28625881/effects-of-exposure-to-biomass-burning-on-pulmonary-inflammatory-markers-and-pulmonary-function-in-individuals-with-copd
#19
D Ramos, M Proença, M R Leite, A D Ferreira, I B Trevisan, G F S Brígida, G Y Tacao, E M C Ramos
INTRODUCTION: Pulmonary rehabilitation (PR) has many benefits for individuals with COPD. However, it is not clear whether PR could prevent the hazards of air pollution exposure. This study aimed to analyze the effects of biomass burning exposure on pulmonary inflammatory markers and pulmonary function in individuals with COPD, participants and non-participants of PR. METHODS: 35 subjects were divided into three groups: individuals with COPD who received PR (G1, n=15), those who did not (G2, n=10), and a control group composed of healthy individuals without COPD (CG, n=10)...
June 15, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28619761/exhaled-breath-condensate-biomarkers-for-the-early-diagnosis-of-lung-cancer-using-proteomics
#20
Laura M López-Sánchez, Bernabé Jurado-Gámez, Nuria Feu-Collado, Araceli Valverde, Amanda Cañas, Jose L Fernández-Rueda, Enrique Aranda, Antonio Rodríguez-Ariza
We explored whether the proteomic analysis of exhaled breath condensate (EBC) may provide biomarkers for non-invasive screening for the early detection of lung cancer (LC). EBC was collected from 192 individuals (49 control (C), 49 risk factor-smoking (S), 46 chronic obstructive pulmonary disease (COPD) and 48 LC (LC)). Using LC-MS/MS, 348 different proteins with a different pattern among the four groups were identified in EBC samples. Significantly more proteins were identified in the EBC from LC compared to other groups (C:12...
June 15, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
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