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Exhaled breath condensate

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https://www.readbyqxmd.com/read/27891048/metabolic-signatures-of-lung-cancer-in-sputum-and-exhaled-breath-condensate-detected-by-1-h-magnetic-resonance-spectroscopy-a-feasibility-study
#1
Naseer Ahmed, Tedros Bezabeh, Omkar B Ijare, Renelle Myers, Reem Alomran, Michel Aliani, Zoann Nugent, Shantanu Banerji, Julian Kim, Gefei Qing, Zoheir Bshouty
OBJECTIVES: Lung cancer is one of the most lethal cancers. Currently, there are no biomarkers for early detection, monitoring treatment response, and detecting recurrent lung cancer. We undertook this study to determine if (1)H magnetic resonance spectroscopy (MRS) of sputum and exhaled breath condensate (EBC), as a noninvasive tool, can identify metabolic biomarkers of lung cancer. MATERIALS AND METHODS: Sputum and EBC samples were collected from 20 patients, comprising patients with pathologically confirmed non-small cell lung cancer (n = 10) and patients with benign respiratory conditions (n = 10)...
2016: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/27880043/mmp-8-mmp-9-and-neutrophil-elastase-in-peripheral-blood-and-exhaled-breath-condensate-in-copd
#2
JieHao Joshua Sng, Silvie Prazakova, Paul S Thomas, Cristan Herbert
Chronic obstructive pulmonary disease (COPD) is characterised by progressive and irreversible airflow limitation associated with chronic inflammation involving cytokines and metalloproteinases (MMPs). MMP-8, MMP-9 and neutrophil elastase (NE) are known to be implicated in COPD but the factors influencing activation and suppression remain unclear. This study aimed to compare MMP-8, MMP-9 and NE in the peripheral blood of COPD patients and controls and to likewise assess exhaled breath condensate (EBC) for these MMPs...
November 23, 2016: COPD
https://www.readbyqxmd.com/read/27869103/th-17-cytokines-and-interstitial-lung-involvement-in-systemic-sclerosis
#3
G Rolla, E Fusaro, S Nicola, C Bucca, C Peroni, S Parisi, M C Cassinis, A Ferraris, F Angelino, E Heffler, M Boita, L Brussino
The two phenotypes of both limited and diffuse systemic sclerosis (SSc) have different forms of pulmonary involvement: pulmonary arterial hypertension (limited phenotype) or interstitial lung disease (ILD) (diffuse phenotype). We aimed to investigate whether Th17-related cytokines, as measured in exhaled breath condensate (EBC) and in serum were connected to ILD in diffuse SSc patients. We found that for both limited and diffuse SSc, the EBC levels of all cytokines and most of the cytokine serum levels were significantly higher in patients than in controls, while, the EBC levels of Th-17 cytokines and the serum levels of IL-10 and TNF-α were significantly higher in diffuse than in limited SSc...
November 21, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27855548/markers-of-lipid-oxidative-damage-in-the-exhaled-breath-condensate-of-nano-tio2-production-workers
#4
Daniela Pelclova, Vladimir Zdimal, Petr Kacer, Nadezda Zikova, Martin Komarc, Zdenka Fenclova, Stepanka Vlckova, Jaroslav Schwarz, Otakar Makeš, Kamila Syslova, Tomas Navratil, Francesco Turci, Ingrid Corazzari, Sergey Zakharov, Dhimiter Bello
Nanoscale titanium dioxide (nanoTiO2) is a commercially important nanomaterial. Animal studies have documented lung injury and inflammation, oxidative stress, cytotoxicity and genotoxicity. Yet human health data are scarce and quantitative risk assessments and biomonitoring of exposure are lacking. NanoTiO2 is classified by IARC as a group 2B, possible human carcinogen. In our earlier studies we documented an increase in markers of inflammation, as well as DNA and protein oxidative damage, in exhaled breath condensate (EBC) of workers exposed nanoTiO2...
November 18, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27835856/respiratory-ocular-and-skin-health-in-recreational-and-competitive-swimmers-beneficial-effect-of-a-new-method-to-reduce-chlorine-oxidant-derivatives
#5
Anton Gomà, Rosó de Lluis, Jordi Roca-Ferrer, Javier Lafuente, César Picado
BACKGROUND: Chlorine by-products may irritate the eyes, nose, skin and airways of swimmers and may cause chronic airway inflammation. OBJECTIVE: To assess the salutary effects on swimmers health of a new method of water disinfection. METHODS: Recreational (n=320) and competitive swimmers (n=53) participated in the study. The first part of the study (Phase A) was carried out while using the current standard method. The second part (Phase B) began 8 weeks after the new method had been introduced...
January 2017: Environmental Research
https://www.readbyqxmd.com/read/27834896/development-of-an-exhaled-breath-monitoring-system-with-semiconductive-gas-sensors-a-gas-condenser-unit-and-gas-chromatograph-columns
#6
Toshio Itoh, Toshio Miwa, Akihiro Tsuruta, Takafumi Akamatsu, Noriya Izu, Woosuck Shin, Jangchul Park, Toyoaki Hida, Takeshi Eda, Yasuhiro Setoguchi
Various volatile organic compounds (VOCs) in breath exhaled by patients with lung cancer, healthy controls, and patients with lung cancer who underwent surgery for resection of cancer were analyzed by gas condenser-equipped gas chromatography-mass spectrometry (GC/MS) for development of an exhaled breath monitoring prototype system involving metal oxide gas sensors, a gas condenser, and gas chromatography columns. The gas condenser-GC/MS analysis identified concentrations of 56 VOCs in the breath exhaled by the test population of 136 volunteers (107 patients with lung cancer and 29 controls), and selected four target VOCs, nonanal, acetoin, acetic acid, and propanoic acid, for use with the condenser, GC, and sensor-type prototype system...
November 10, 2016: Sensors
https://www.readbyqxmd.com/read/27826890/acute-response-to-cigarette-smoking-assessed-in-exhaled-breath-condensate-in-patients-with-chronic-obstructive-pulmonary-disease-and-healthy-smokers
#7
M Maskey-Warzęchowska, P Nejman-Gryz, K Osinka, P Lis, K Malesa, K Górska, R Krenke
The effect of acute exposure to cigarette smoke (CS) on the respiratory system has been less extensively studied than the long term effects of smoking. The aim of the present study was to evaluate the acute response to CS in smokers suffering from chronic obstructive pulmonary disease (COPD) and in healthy smokers. Nineteen stable COPD patients and 19 young healthy smokers were enrolled. Tumor necrosis factor alpha (TNF-α), IL-1β, and malondialdehyde (MDA) were measured in exhaled breath condensate (EBC) before and 60 min after smoking a cigarette...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27821429/non-invasive-lung-cancer-diagnosis-by-detection-of-gata6-and-nkx2-1-isoforms-in-exhaled-breath-condensate
#8
Aditi Mehta, Julio Cordero, Stephanie Dobersch, Addi J Romero-Olmedo, Rajkumar Savai, Johannes Bodner, Cho-Ming Chao, Ludger Fink, Ernesto Guzmán-Díaz, Indrabahadur Singh, Gergana Dobreva, Ulf R Rapp, Stefan Günther, Olga N Ilinskaya, Saverio Bellusci, Reinhard H Dammann, Thomas Braun, Werner Seeger, Stefan Gattenlöhner, Achim Tresch, Andreas Günther, Guillermo Barreto
Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. Early LC diagnosis is crucial to reduce the high case fatality rate of this disease. In this case-control study, we developed an accurate LC diagnosis test using retrospectively collected formalin-fixed paraffin-embedded (FFPE) human lung tissues and prospectively collected exhaled breath condensates (EBCs). Following international guidelines for diagnostic methods with clinical application, reproducible standard operating procedures (SOP) were established for every step comprising our LC diagnosis method...
December 1, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27792151/elimination-of-drifts-in-long-duration-monitoring-for-apnea-hypopnea-of-human-respiration
#9
Peng Jiang, Rong Zhu
This paper reports a methodology to eliminate an uncertain baseline drift in respiratory monitoring using a thermal airflow sensor exposed in a high humidity environment. Human respiratory airflow usually contains a large amount of moisture (relative humidity, RH > 85%). Water vapors in breathing air condense gradually on the surface of the sensor so as to form a thin water film that leads to a significant sensor drift in long-duration respiratory monitoring. The water film is formed by a combination of condensation and evaporation, and therefore the behavior of the humidity drift is complicated...
October 25, 2016: Sensors
https://www.readbyqxmd.com/read/27777105/effects-of-occupational-exposure-to-poorly-soluble-forms-of-beryllium-on-biomarkers-of-pulmonary-response-in-exhaled-breath-of-workers-in-machining-industries
#10
Anca Radauceanu, Michel Grzebyk, Jean-Louis Edmé, Nathalie Chérot-Kornobis, Davy Rousset, Mathieu Dziurla, Virginie De Broucker, Guy Hédelin, Annie Sobaszek, Sébastien Hulo
OBJECTIVE: To analyze the effects of occupational exposure to poorly soluble forms of beryllium (Be) on biomarkers of pulmonary inflammation using exhaled breath condensate (EBC) in workers employed in machining industries. METHODS: Twenty machining operators were compared to 16 controls. The individual exposure to Be was assessed from the work history with several indices of exposure calculated on the basis of task-exposures matrices developed for each plant using historical air measurements...
October 21, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27776981/asthma-metabolomics-and-the-potential-for-integrative-omics-in-research-and-the-clinic
#11
Rachel S Kelly, Amber Dahlin, Michael J McGeachie, Weiliang Qiu, Joanne Sordillo, Emily S Wan, Ann Chen Wu, Jessica Lasky-Su
Asthma is a complex disease well suited to metabolomic profiling, both for the development of novel biomarkers and for the improved understanding of pathophysiology. In this review, we summarize the 21 existing metabolomic studies of asthma in humans, all of which reported significant findings and concluded that individual metabolites and metabolomic profiles measured in exhaled breath condensate, urine, plasma and serum could identify asthmatics and asthma phenotypes with high discriminatory ability. There was considerable consistency across the studies in terms of the reported biomarkers, regardless of biospecimen, profiling technology and population age...
October 21, 2016: Chest
https://www.readbyqxmd.com/read/27764146/noninvasive-recognition-and-biomarkers-of-early-allergic-asthma-in-cats-using-multivariate-statistical-analysis-of-nmr-spectra-of-exhaled-breath-condensate
#12
Yan G Fulcher, Martial Fotso, Chee-Hoon Chang, Hans Rindt, Carol R Reinero, Steven R Van Doren
Asthma is prevalent in children and cats, and needs means of noninvasive diagnosis. We sought to distinguish noninvasively the differences in 53 cats before and soon after induction of allergic asthma, using NMR spectra of exhaled breath condensate (EBC). Statistical pattern recognition was improved considerably by preprocessing the spectra with probabilistic quotient normalization and glog transformation. Classification of the 106 preprocessed spectra by principal component analysis and partial least squares with discriminant analysis (PLS-DA) appears to be impaired by variances unrelated to eosinophilic asthma...
2016: PloS One
https://www.readbyqxmd.com/read/27757939/comparison-of-thymic-stromal-lymphopoietin-concentration-in-various-human-biospecimens-from-asthma-and-copd-patients-measured-with-two-different-elisa-kits
#13
Katarzyna Górska, Patrycja Nejman-Gryz, Magdalena Paplińska-Goryca, Małgorzata Proboszcz, Rafał Krenke
Thymic stromal lymphopoietin (TSLP) seems a promising asthma biomarker. In earlier studies, mainly the serum concentration of TSLP was investigated. The aim of the present study was to compare the TSLP concentration measured by two different ELISA kits in the serum, induced sputum, and exhaled breath condensate in asthma, COPD, and control subjects. The study included 24 asthmatics, 36 patients with COPD, and 12 controls. TSLP concentration was measured with the use of R&D and EIAab commercial ELISA kits. The results obtained with the EIAab kit were 3 to even 45-fold higher than those measured with the R&D kit...
October 19, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27754970/markers-of-lipid-oxidative-damage-among-office-workers-exposed-intermittently-to-air-pollutants-including-nanotio2-particles
#14
Daniela Pelclova, Vladimir Zdimal, Petr Kacer, Martin Komarc, Zdenka Fenclova, Stepanka Vlckova, Nadezda Zikova, Jaroslav Schwarz, Otakar Makes, Tomas Navratil, Sergey Zakharov, Dhimiter Bello
Nanoscale titanium dioxide (nanoTiO2) is a commercially important nanomaterial used in numerous applications. Experimental studies with nanotitania have documented lung injury and inflammation, oxidative stress, and genotoxicity. Production workers in TiO2 manufacturing with a high proportion of nanoparticles and a mixture of other air pollutants, such as gases and organic aerosols, had increased markers of oxidative stress, including DNA and protein damage, as well as lipid peroxidation in their exhaled breath condensate (EBC) compared to unexposed controls...
October 18, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27746236/coexistence-of-obesity-and-asthma-determines-a-distinct-respiratory-metabolic-phenotype
#15
Mauro Maniscalco, Debora Paris, Dominique J Melck, Maria D'Amato, Anna Zedda, Matteo Sofia, Cristiana Stellato, Andrea Motta
BACKGROUND: Epidemiologic and clinical evidence supports the existence of an obesity-related asthma phenotype. No distinct pathophysiologic elements or specific biomarkers have been identified thus far, but increased oxidative stress has been reported. OBJECTIVE: We aimed at verifying whether metabolomics of exhaled breath condensate from obese asthmatic (OA) patients, lean asthmatic (LA) patients, and obese nonasthmatic (ONA) subjects could recognize specific and statistically validated biomarkers for a separate "asthma-obesity" respiratory metabolic phenotype, here defined as "metabotype...
October 14, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27730191/hydrogen-peroxide-in-exhaled-air-a-source-of-error-a-paradox-and-its-resolution
#16
Stefan Peters, Angelika Kronseder, Stefan Karrasch, Petra A Neff, Matz Haaks, Andreas R Koczulla, Petra Reinhold, Dennis Nowak, Rudolf A Jörres
The concentration of hydrogen peroxide (H2O2) in exhaled air has been reported to be elevated in asthma and chronic obstructive pulmonary disease (COPD), but results are inconsistent and difficult to reproduce. As H2O2 occurs in ambient air, we examined its association with exhaled H2O2 in human subjects. Exhaled breath condensate (EBC) of 12 COPD patients and nine healthy control subjects was collected either with an inhalation filter (efficiency 81%) or without. Ambient air condensate (AAC) was collected in parallel and samples were analysed for H2O2...
April 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27720040/elevated-prostaglandin-e-metabolites-and-abnormal-plasma-fatty-acids-at-baseline-in-pediatric-cystic-fibrosis-patients-a-pilot-study
#17
Michael Glenn O'Connor, Kelly Thomsen, Rebekah F Brown, Michael Laposata, Adam Seegmiller
BACKGROUND: Airway inflammation is a significant contributor to the morbidity of cystic fibrosis (CF) disease. One feature of this inflammation is the production of oxygenated metabolites, such as prostaglandins. Individuals with CF are known to have abnormal metabolism of fatty acids, typically resulting in reduced levels of linoleic acid (LA) and docosahexaenoic acid (DHA). METHODS: This is a randomized, double-blind, cross-over clinical trial of DHA supplementation with endpoints of plasma fatty acid levels and prostaglandin E metabolite (PGE-M) levels...
October 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27709308/evaluation-of-the-improvement-effect-of-laser-acupuncture-biostimulation-in-asthmatic-children-by-exhaled-inflammatory-biomarker-level-of-nitric-oxide
#18
Ola A Dabbous, Mona M Soliman, Nagwa H Mohamed, Magda Y Elseify, Mai S Elsheikh, Asmaa A A Alsharkawy, Manal M Abd Al Aziz
Variable therapy of asthma is not sufficient yet to achieve good asthma control. Therapy decision requires serial investigations. Low-level laser acupuncture is a suitable non-invasive modality of complementary medicine. The exhaled breath condensate (EBC) is easy and useful to evaluate the efficacy of drugs or novel therapy. This study aimed to evaluate the effectiveness of low-level laser biostimulation of acupuncture points on asthma improvement in children. Forty-eight asthmatic children were subdivided into case (laser) group, which received 12 direct contact low-power laser acupuncture sessions (three sessions/week) on specific traditional Chinese acupuncture points for bronchial asthma, and control asthmatic group, which received sham laser acupuncture on the same acupoints and number of sessions of the case (laser) group...
October 5, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27697073/cigarette-smoke-mediated-perturbations-of-the-immune-response-a-new-therapeutic-approach-with-natural-compounds
#19
Thea Magrone, Emilio Jirillo
Cigarette smoke (CS) accounts for the outcome of several pathologies, even including lung cancer, cardiovascular disease and chronic obstructive pulmonary disease (COPD). Under healthy conditions, lung immune system becomes tolerant in response to various external stimuli. CS exposure alters the pulmonary immune equilibrium, thus leading to a condition of hyper activation of the local innate and adaptive immunity. COPD is one of the major complications of chronic CS exposure where a pro-inflammatory profile of the pulmonary and systemic immunity is predominant...
September 27, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27689905/enhanced-non-invasive-respiratory-sampling-from-bottlenose-dolphins-for-breath-metabolomics-measurements
#20
Konstantin O Zamuruyev, Alexander A Aksenov, Mark Baird, Alberto Pasamontes, Celeste Parry, Soraya Foutouhi, Stephanie Venn-Watson, Bart C Weimer, Jean-Pierre Delplanque, Cristina E Davis
Chemical analysis of exhaled breath metabolites is an emerging alternative to traditional clinical testing for many physiological conditions. The main advantage of breath analysis is its inherent non-invasive nature and ease of sample collection. Therefore, there exists a great interest in further development of this method for both humans and animals. The physiology of cetaceans is exceptionally well suited for breath analysis due to their explosive breathing behavior and respiratory tract morphology. At the present time, breath analysis in cetaceans has very limited practical applications, in large part due to lack of widely adopted sampling device(s) and methodologies that are well-standardized...
2016: Journal of Breath Research
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