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Exhaled breath condensate

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https://www.readbyqxmd.com/read/28068297/fatty-acid-derivative-chemokine-and-cytokine-profiles-in-exhaled-breath-condensates-can-differentiate-adult-and-children-paucibacillary-tuberculosis-patients
#1
Sergio Fabián Mosquera-Restrepo, Ana Cecilia Caro, Luis F García, Carlos Alberto Peláez-Jaramillo, Mauricio Rojas
The anti-mycobacterial immune response in adults and children with tuberculosis (TB), as well as the response in bacteriologically positive and negative patients, is different. However, knowledge of the immunological events occurring in the lungs in these clinical situations remains scarce. Exhaled breath condensate (EBC) samples may be useful for studying the inflammatory environment of the lower airways in TB patients. The fatty acid, cytokine, and chemokine profiles in EBC from healthy adults; smear-positive and smear-negative adult patients; and healthy, asthmatic, and TB children were determined using gas chromatography and LUMINEX, respectively...
January 9, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28054515/method-validation-of-nanoparticle-tracking-analysis-to-measure-pulmonary-nanoparticle-content-the-size-distribution-in-exhaled-breath-condensate-depends-on-occupational-exposure
#2
Jean-Jacques Sauvain, Guillaume Suarez, Jean-Louis Edmé, Olivia Maria de Paula Alvez Bezerra, Keller Silveira, Lenio Amaral, Ana Paula Carneiro, Natalie Cherot-Kornobis, Annie Sobaszek, Sébastien Hulo
A particle exposure assessment based on the dose deposited in the lungs would be the gold standard for the evaluation of any resulting health effects. Measuring particles in exhaled breath condensate (EBC)-a matrix containing water and airway lining fluid-could help to evaluate particle retention in the lungs. This study aimed to (1) validate a nanoparticle tracking analysis (NTA) method for determining the particle number concentration and their hydrodynamic size distribution in EBC, and (2) apply this method to EBC collected from workers exposed to soapstone (n = 55) or quartz dust (n = 12) and controls (n = 11)...
January 5, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28041585/exhaled-breath-condensate-in-asthma-are-we-stupid-if-we-do-not-keep-it-simple
#3
EDITORIAL
L Garcia-Marcos
No abstract text is available yet for this article.
January 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28040456/exhaled-breath-condensate-analysis-from-intubated-newborns-by-nano-hplc-coupled-to-high-resolution-ms
#4
A S Kononikhin, N L Starodubtseva, V V Chagovets, A Y Ryndin, A A Burov, I A Popov, A E Bugrova, R A Dautov, A O Tokareva, Y L Podurovskaya, O V Ionov, V E Frankevich, E N Nikolaev, G T Sukhikh
Invasiveness of examination and therapy methods is a serious problem for intensive care and nursing of premature infants. Exhaled breath condensate (EBC) is the most attractive biofluid for non-invasive methods development in neonatology for monitoring the status of intubated infants. The aim of the study was to propose an approach for EBC sampling and analysis from mechanically ventilated neonates. EBC collection system with good reproducibility of sampling was demonstrated. Discovery-based proteomic and metabolomic studies were performed using nano-HPLC coupled to high resolution MS...
December 23, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28038794/prognostic-role-of-exhaled-breath-condensate-ph-and-fraction-exhaled-nitric-oxide-in-systemic-sclerosis-related-interstitial-lung-disease
#5
Alfredo Guillen-Del Castillo, Sara Sánchez-Vidaurre, Carmen P Simeón-Aznar, María J Cruz, Vicente Fonollosa-Pla, Xavier Muñoz
INTRODUCTION: Interstitial lung disease (ILD) is one of the major causes of death in systemic sclerosis (SSc). This study investigated exhaled breath (EB) and exhaled breath condensate (EBC) biomarkers in patients with SSc and analyzed their role as a prognostic tool in SSc-related ILD. METHODS: Fraction exhaled nitric oxide (FeNO) and exhaled carbon monoxide (eCO) measured in EB, together with pH, nitrite, nitrate and interleukin-6 levels measured in EBC were prospectively analyzed in 35 patients with SSc...
December 27, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28004646/exhaled-breath-condensate-ph-and-cysteinyl-leukotriens-in-patients-with-chronic-cough-secondary-to-acid-gastroesophageal-reflux
#6
Enrico Heffler, Claudia Crimi, Luisa Brussino, Stefania Nicola, Stefania Sichili, Luca Dughera, Giovanni Rolla, Nunzio Crimi
Chronic cough is one of the most common clinical problems and it may be secondary to different stimuli and diseases, including low-level physical and chemical stimulation of the esophageal-bronchial reflex, suggestive of cough-reflex hyperresponsiveness, in patients with gastroesophageal reflux; however, it is still debated whether gastroesophageal reflux could induce airway inflammation and acidification. The aim of this study was to investigate airway pH and cysteynil-leukotrienes (Cys-LTs) concentration (a marker of airway inflammation) in exhaled breath condensate (EBC)...
December 22, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/28004639/human-breath-metabolomics-using-an-optimized-non-invasive-exhaled-breath-condensate-sampler
#7
Konstantin O Zamuruyev, Alexander A Aksenov, Alberto Pasamontes, Joshua F Brown, Dayna R Pettit, Soraya Foutouhi, Bart C Weimer, Michael Schivo, Nicholas J Kenyon, Jean-Pierre Delplanque, Cristina E Davis
Exhaled breath condensate (EBC) analysis is a developing field with tremendous promise to advance personalized, non-invasive health diagnostics as new analytical instrumentation platforms and detection methods are developed. Multiple commercially-available and researcher-built experimental samplers are reported in the literature. However, there is very limited information available to determine an effective breath sampling approach, especially regarding the dependence of breath sample metabolomic content on the collection device design and sampling methodology...
December 22, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/28000620/aerobic-exercise-in-polluted-urban-environments-effects-on-airway-defense-mechanisms-in-young-healthy-amateur-runners
#8
Matheus Cavalcante de Sá, Naomi Kondo Nakagawa, Carmen Diva Saldiva de André, Regiani Carvalho-Oliveira, Tômas de Santana Carvalho, Marina Lazzari Nicola, Paulo Afonso de André, Paulo Hilario Nascimento Saldiva, Mauro Vaisberg
In this study, the effects of aerobic exercise on the upper airways and their defense mechanisms were investigated in athletes. The athletes ran in two different environments: the downtown streets of the city of São Paulo (Street), more polluted, and an urban forest (Forest), less polluted. Thirty-eight young healthy athletes ran for 45 min d(-1) randomly during five consecutive days, with an interval of 48 h before changing environment. Clinical parameters and respiratory tract defense markers were evaluated before and after the first run on Mondays (1 d) and on Fridays (5 d)...
December 21, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27994663/new-panel-of-microsatellite-alterations-detectable-in-the-ebc-for-lung-cancer-prognosis
#9
Giovanna E Carpagnano, Donato Lacedonia, Elisabetta Crisetti, Domenico Martinelli, Maria P Foschino-Barbaro
Our research group demonstrated, in a precedent study, the prognostic power of the 3p microsatellites alterations (MAs) detectable in exhaled breath condensate (EBC) in NSCLC patients. The analysis of genetic markers in the EBC might have precious clinical and economic consequences when inserted in diagnostic and follow up programs for lung cancer. The aim of this study was to evaluate the prognostic value of a new panel of MAs in the EBC of patients with NSCLC. We enrolled 45 NSCLC patients during a period of 36 months and the follow-up period was 156 weeks...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27956251/the-simultaneous-detection-of-trivalent-hexavalent-chromium-in-exhaled-breath-condensate-a-feasibility-study-comparing-workers-and-controls
#10
Elizabeth Leese, Jackie Morton, Philip H E Gardiner, Vikki A Carolan
The analytical method outlined in this feasibility study has been used to show that trivalent chromium (Cr(III)) and hexavalent chromium (Cr(VI)) can be detected and measured in exhaled breath condensate (EBC) samples. EBC samples and urine samples were collected from a cohort of 58 workers occupationally exposed to hexavalent chromium compounds and 22 unexposed volunteers (control group). Levels of Cr(III) and Cr(VI) were determined in EBC samples and total chromium levels were determined in urine samples...
December 6, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27931302/new-insights-into-treatment-of-children-with-exercise-induced-asthma-symptoms
#11
Iwona Stelmach, Anna Sztafiska, Joanna Jerzyska, Daniela Podlecka, Pawe Majak, Wodzimierz Stelmach
BACKGROUND: Exercise is one of the most common triggers of bronchoconstriction and affects up to 80% of children with asthma. OBJECTIVE: The purpose of this randomized, double-blind, placebo-controlled study was to assess the effectiveness of treatment with ciclesonide 160 microgram, either alone, with a higher dose, with a leukotriene receptor antagonist (LTRA), or with a long-acting beta-agonist (LABA) in children with asthma with postexercise-induced symptoms...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27931275/serum-tryptase-level-and-inflammatory-markers-in-exhaled-breath-condensate-of-children-with-exercise-induced-symptoms
#12
Iwona Stelmach, Magdalena Zaczeniuk, Anna Sztafiska, Pawe Majak, Joanna Jerzyska, Anna Kuklinska-Pijanka, Wlodzimierz Stelmach
BACKGROUND: The pathogenesis of exercise-induced bronchoconstriction (EIB) is poorly understood. OBJECTIVE: To evaluate the biomarkers concentration in exhaled breath condensate (EBC) in schoolchildren with postexercise symptoms. We also evaluated changes in fractional exhaled nitric oxide (FeNO) value and the serum tryptase level after exercise. METHODS: One hundred children with postexercise symptoms were included. Methacholine challenge testing (MCT) was performed at visit 2, and exercise challenge testing (ECT) was performed at visit 3...
September 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27913298/a-novel-monoclonal-antibody-suitable-for-the-detection-of-leukotriene-b4
#13
Steffi Lütkecosmann, Axel Warsinke, Winfried Tschöpe, Rüdiger Eichler, Katja Hanack
Leukotriene B4 as an inflammatory mediator is an important biomarker for different respiratory diseases like asthma, chronic obstructive pulmonary disease or cystic lung fibrosis. Therefore the detection of LTB4 is helpful in the diagnosis of these pulmonary diseases. However, until now its determination in exhaled breath condensates suffers from problems of accuracy. Reasons for that could be improper sample collection and preparation methods of condensates and the lack of consistently assay specificity and reproducibility of the used immunoassay detection system...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27891048/metabolic-signatures-of-lung-cancer-in-sputum-and-exhaled-breath-condensate-detected-by-1-h-magnetic-resonance-spectroscopy-a-feasibility-study
#14
Naseer Ahmed, Tedros Bezabeh, Omkar B Ijare, Renelle Myers, Reem Alomran, Michel Aliani, Zoann Nugent, Shantanu Banerji, Julian Kim, Gefei Qing, Zoheir Bshouty
OBJECTIVES: Lung cancer is one of the most lethal cancers. Currently, there are no biomarkers for early detection, monitoring treatment response, and detecting recurrent lung cancer. We undertook this study to determine if (1)H magnetic resonance spectroscopy (MRS) of sputum and exhaled breath condensate (EBC), as a noninvasive tool, can identify metabolic biomarkers of lung cancer. MATERIALS AND METHODS: Sputum and EBC samples were collected from 20 patients, comprising patients with pathologically confirmed non-small cell lung cancer (n = 10) and patients with benign respiratory conditions (n = 10)...
2016: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/27880043/mmp-8-mmp-9-and-neutrophil-elastase-in-peripheral-blood-and-exhaled-breath-condensate-in-copd
#15
JieHao Joshua Sng, Silvie Prazakova, Paul S Thomas, Cristan Herbert
Chronic obstructive pulmonary disease (COPD) is characterised by progressive and irreversible airflow limitation associated with chronic inflammation involving cytokines and metalloproteinases (MMPs). MMP-8, MMP-9 and neutrophil elastase (NE) are known to be implicated in COPD but the factors influencing activation and suppression remain unclear. This study aimed to compare MMP-8, MMP-9 and NE in the peripheral blood of COPD patients and controls and to likewise assess exhaled breath condensate (EBC) for these MMPs...
November 23, 2016: COPD
https://www.readbyqxmd.com/read/27869103/th-17-cytokines-and-interstitial-lung-involvement-in-systemic-sclerosis
#16
G Rolla, E Fusaro, S Nicola, C Bucca, C Peroni, S Parisi, M C Cassinis, A Ferraris, F Angelino, E Heffler, M Boita, L Brussino
The two phenotypes of both limited and diffuse systemic sclerosis (SSc) have different forms of pulmonary involvement: pulmonary arterial hypertension (limited phenotype) or interstitial lung disease (ILD) (diffuse phenotype). We aimed to investigate whether Th17-related cytokines, as measured in exhaled breath condensate (EBC) and in serum were connected to ILD in diffuse SSc patients. We found that for both limited and diffuse SSc, the EBC levels of all cytokines and most of the cytokine serum levels were significantly higher in patients than in controls, while, the EBC levels of Th-17 cytokines and the serum levels of IL-10 and TNF-α were significantly higher in diffuse than in limited SSc...
November 21, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27855548/markers-of-lipid-oxidative-damage-in-the-exhaled-breath-condensate-of-nano-tio2-production-workers
#17
Daniela Pelclova, Vladimir Zdimal, Petr Kacer, Nadezda Zikova, Martin Komarc, Zdenka Fenclova, Stepanka Vlckova, Jaroslav Schwarz, Otakar Makeš, Kamila Syslova, Tomas Navratil, Francesco Turci, Ingrid Corazzari, Sergey Zakharov, Dhimiter Bello
Nanoscale titanium dioxide (nanoTiO2) is a commercially important nanomaterial. Animal studies have documented lung injury and inflammation, oxidative stress, cytotoxicity and genotoxicity. Yet, human health data are scarce and quantitative risk assessments and biomonitoring of exposure are lacking. NanoTiO2 is classified by IARC as a group 2B, possible human carcinogen. In our earlier studies we documented an increase in markers of inflammation, as well as DNA and protein oxidative damage, in exhaled breath condensate (EBC) of workers exposed nanoTiO2...
December 9, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27835856/respiratory-ocular-and-skin-health-in-recreational-and-competitive-swimmers-beneficial-effect-of-a-new-method-to-reduce-chlorine-oxidant-derivatives
#18
Anton Gomà, Rosó de Lluis, Jordi Roca-Ferrer, Javier Lafuente, César Picado
BACKGROUND: Chlorine by-products may irritate the eyes, nose, skin and airways of swimmers and may cause chronic airway inflammation. OBJECTIVE: To assess the salutary effects on swimmers health of a new method of water disinfection. METHODS: Recreational (n=320) and competitive swimmers (n=53) participated in the study. The first part of the study (Phase A) was carried out while using the current standard method. The second part (Phase B) began 8 weeks after the new method had been introduced...
January 2017: Environmental Research
https://www.readbyqxmd.com/read/27834896/development-of-an-exhaled-breath-monitoring-system-with-semiconductive-gas-sensors-a-gas-condenser-unit-and-gas-chromatograph-columns
#19
Toshio Itoh, Toshio Miwa, Akihiro Tsuruta, Takafumi Akamatsu, Noriya Izu, Woosuck Shin, Jangchul Park, Toyoaki Hida, Takeshi Eda, Yasuhiro Setoguchi
Various volatile organic compounds (VOCs) in breath exhaled by patients with lung cancer, healthy controls, and patients with lung cancer who underwent surgery for resection of cancer were analyzed by gas condenser-equipped gas chromatography-mass spectrometry (GC/MS) for development of an exhaled breath monitoring prototype system involving metal oxide gas sensors, a gas condenser, and gas chromatography columns. The gas condenser-GC/MS analysis identified concentrations of 56 VOCs in the breath exhaled by the test population of 136 volunteers (107 patients with lung cancer and 29 controls), and selected four target VOCs, nonanal, acetoin, acetic acid, and propanoic acid, for use with the condenser, GC, and sensor-type prototype system...
November 10, 2016: Sensors
https://www.readbyqxmd.com/read/27826890/acute-response-to-cigarette-smoking-assessed-in-exhaled-breath-condensate-in-patients-with-chronic-obstructive-pulmonary-disease-and-healthy-smokers
#20
M Maskey-Warzęchowska, P Nejman-Gryz, K Osinka, P Lis, K Malesa, K Górska, R Krenke
The effect of acute exposure to cigarette smoke (CS) on the respiratory system has been less extensively studied than the long term effects of smoking. The aim of the present study was to evaluate the acute response to CS in smokers suffering from chronic obstructive pulmonary disease (COPD) and in healthy smokers. Nineteen stable COPD patients and 19 young healthy smokers were enrolled. Tumor necrosis factor alpha (TNF-α), IL-1β, and malondialdehyde (MDA) were measured in exhaled breath condensate (EBC) before and 60 min after smoking a cigarette...
2017: Advances in Experimental Medicine and Biology
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