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https://www.readbyqxmd.com/read/29909235/regulation-of-prostate-cancer-by-hormone-responsive-g-protein-coupled-receptors
#1
REVIEW
Wei Wang, Zhao-Xia Chen, Dong-Yu Guo, Ya-Xiong Tao
Regulation of prostate cancer by androgen and androgen receptor (AR), and blockade of AR signaling by AR antagonists and steroidogenic enzyme inhibitors have been extensively studied. G protein-coupled receptors (GPCRs) are a family of membrane receptors that regulate almost all physiological processes. Nearly 40% of FDA-approved drugs in the market target GPCRs. A variety of GPCRs that mediate reproductive function have been demonstrated to be involved in the regulation of prostate cancer. These GPCRs include gonadotropin-releasing hormone receptor, luteinizing hormone receptor, follicle-stimulating hormone receptor, relaxin receptor, ghrelin receptor, and kisspeptin receptor...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29906665/reproductive-performance-of-bos-indicus-beef-cows-treated-with-different-doses-of-equine-chorionic-gonadotropin-at-the-end-of-a-progesterone-estrogen-based-protocol-for-fixed-time-artificial-insemination
#2
Rafael Herrera Alvarez, Guilherme Pugliesi, Fabio Luis Nogueira Natal, Cecilia Constantino Rocha, Gilmar Arantes Ataide Júnior, Alfredo José Ferreira Melo, Ivani Posar Otzuk, Claudio Alvarenga de Oliveira, Patrice Humblot
Two experiments were performed to evaluate the reproductive performance of zebu beef cows treated with different doses of eCG at the end of a progesterone (P4)/estrogen based protocol for timed artificial insemination (TAI). In Experiment 1, suckling Bos indicus Nelore cows (n = 261) received, on day 0, a progesterone (P4) intravaginal device (PD) and an injection of 1 mg estradiol benzoate (EB). On day 8, the PD was removed, 500 μg of cloprostenol was injected, and cows were assigned to one of the following groups: Control (no treatment), 300 (300 IU of eCG), 600 (600 IU of eCG), and 900 (900 IU of eCG)...
June 8, 2018: Theriogenology
https://www.readbyqxmd.com/read/29905829/two-hormones-for-one-receptor-evolution-biochemistry-actions-and-pathophysiology-of-lh-and-hcg
#3
Livio Casarini, Daniele Santi, Giulia Brigante, Manuela Simoni
Luteinizing hormone (LH) and chorionic gonadotropin (CG) are glycoproteins fundamental for sexual development and reproduction. Since they act on the same receptor (LHCGR), there is a general consensus that LH and hCG are equivalent. However, separate evolution of LHβ and hCGβ subunits occurred in primates, resulting in two molecules sharing ∼85% identity and regulating different physiological events. Pituitary, pulsatile LH production results in a ∼90 min half-life molecule targeting the gonads, to regulate gametogenesis and androgen synthesis...
June 13, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29904499/pituitary-stalk-interruption-syndrome-presenting-in-a-euthyroid-adult-with-short-stature
#4
Atif Nawaz, Muhammad Azeemuddin, Jehanzeb Shahid
Pituitary stalk interruption syndrome (PSIS) is a distinct and rare clinical entity responsible for congenital hypopituitarism resulting in deficiency of pituitary hormones with deficiency of the growth hormone (100%) and gonadotropins (97.2%) being its most common presentation at the time of hospital encounter (Wang et al., 2015). Isolated sparing of thyroid-stimulating hormone (TSH) with deficiency of the remaining anterior pituitary hormones may be present in PSIS, as is true in our case. Therefore, it should be kept in mind at the time of examination in suspected cases of PSIS...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29904420/analysis-of-the-efficacy-of-resveratrol-treatment-in-patients-with-scarred-uterus
#5
Huashu Ma, Zongxu Qiao
Scarred uterus is caused by cesarean section surgery, and this condition affects further gestation and delivery in patients. Previous evidence suggested that resveratrol, a polyphenol compound, presents beneficial outcomes for patients with scarred uterus. Therefore, the aim of the present study was to analyze the efficacy of resveratrol in the treatment of patients with scarred uterus. The efficacy of resveratrol in the formation of new vessels and re-epithelialization of the endometrium was analyzed. The present results demonstrated that resveratrol treatment reduced uterus scarring in the majority of patients (87...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29902942/the-role-of-kisspeptin-neurokinin-b-dynorphin-neurons-in-pathomechanism-of-vasomotor-symptoms-in-postmenopausal-women-from-physiology-to-potential-therapeutic-applications
#6
Anna Szeliga, Adam Czyzyk, Agnieszka Podfigurna, Andrea R Genazzani, Alessandro D Genazzani, Blazej Meczekalski
Women during perimenopausal period experience a range of symptoms, which interfere with physical, sexual, and social life. About 65-75% of symptoms connected with postmenopausal period are vasomotor symptoms (VMS), such as hot flushes and night sweats. Hot flushes are subjective sensation of heat associated with cutaneous vasodilatation and drop in core temperature. It is suspected that VMS are strongly correlated with pulsatile oversecretion of gonadotropin-releasing hormone (GnRH) and subsequently luteinizing hormone (LH)...
June 14, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29900796/the-acute-phase-and-hemostatic-response-in-dromedary-camels-camelus-dromedarius
#7
Eva Maria Greunz, Anne K H Krogh, Wouter Pieters, Olga Amann Ruiz, Julia Bohner, Anja Reckendorf, Davide Monaco, Mads Frost Bertelsen
  Acute-phase reactants indicate inflammation and are increasingly used in veterinary medicine to indicate and to monitor progression of disease. Hemostasis and inflammation have interconnected pathophysiologic pathways and influence each other on different levels. This study established observed normal ranges for acute-phase reactants and for coagulation and thromboelastographic (TEG) parameters in 49 dromedary camels ( Camelus dromedarius) and assessed the response to chronic and acute inflammation. Chronically infected animals suffering from lymph abscessation due to Corynebacterium spp...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29900397/differentially-regulated-genes-in-esr2-mutant-rat-granulosa-cells
#8
Vincentaben Khristi, V Praveen Chakravarthi, Prabhakar Singh, Subhra Ghosh, Archit Pramanik, Anamika Ratri, Shaon Borosha, Katherine F Roby, Michael W Wolfe, M A Karim Rumi
RNA seq analyses were performed in granulosa cells (GCs) collected from gonadotropin treated ESR2 mutant rats. Data obtained from a null mutant with Esr2 exon 3 deletion (∆3) and another DNA binding domain (DBD) mutant with exon 4 deletion (∆4) were compared to that of wildtype (WT) rats. The raw data were analyzed using CLC genomics workbench. High quality RNA-sequencing reads were aligned to the Rattus norvegicus genome. Differentially expressed genes in ∆3 or ∆4 Esr2 -mutant GCs were identified based on the following criteria: FDR p-Value ≤0...
August 2018: Data in Brief
https://www.readbyqxmd.com/read/29899190/up-regulation-of-dusp5-and-dusp6-by-gonadotropin-releasing-hormone-in-cultured-hypothalamic-neurons-gt1-7-cells
#9
Teruyuki Higa, Hana Takahashi, Sayomi Higa-Nakamine, Mikio Suzuki, Hideyuki Yamamoto
Gonadotropin-releasing hormone (GnRH) is secreted from hypothalamic neurons (GnRH neurons) and stimulates anterior pituitary gonadotrophs to synthesize and secrete gonadotropins. In addition to gonadotrophs, GnRH neurons also express GnRH receptors, and the autocrine action of GnRH is reportedly involved in the regulation of functions of GnRH neurons. There is accumulating evidence that extracellular signal-regulated kinase (ERK), one of mitogen-activated protein kinases (MAPKs), is activated by GnRH and involved in various effects of GnRH in GnRH neurons...
2018: Biomedical Research
https://www.readbyqxmd.com/read/29899026/dominant-neuropeptide-co-transmission-in-kisspeptin-gaba-regulation-of-gnrh-neuron-firing-driving-ovulation
#10
Richard Piet, Bruna Kalil, Tim McLennan, Robert Porteous, Katja Czieselsky, Allan E Herbison
A population of kisspeptin-GABA co-expressing neurons located in the rostral periventricular area of the third ventricle (RP3V) is believed to activate gonadotropin-releasing hormone (GnRH) neurons to generate the luteinizing hormone (LH) surge triggering ovulation. Selective optogenetic activation of RP3V kisspeptin (RP3VKISS ) neurons in female mice for >30s and ≥10Hz in either a continuous or bursting mode was found to reliably generate a delayed and long-lasting activation of GnRH neuron firing in brain slices...
June 13, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29897458/increased-aif-1-mediated-tnf-%C3%AE-expression-during-implantation-phase-in-ivf-cycles-with-gnrh-antagonist-protocol
#11
Bufang Xu, Mingjuan Zhou, Jingwen Wang, Dan Zhang, Feng Guo, Chenchen Si, Peter C K Leung, Aijun Zhang
STUDY QUESTION: Is allograft inflammatory factor-1 (AIF-1), a cytokine associated with inflammation and allograft rejection, aberrantly elevated in in vitro fertilization (IVF) cycles with gonadotropin-releasing hormone (GnRH) antagonist protocol with potential effects on endometrial receptivity? SUMMARY ANSWER: Our findings indicated AIF-1 is increased in IVF cycles with GnRH antagonist protocol and mediates greater TNF-α expression during implantation phase, which may be unfavorable for embryo implantation...
June 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29897442/latent-genital-tuberculosis-adversely-affects-the-ovarian-reserve-in-infertile-women
#12
P R Jirge, S M Chougule, A Keni, S Kumar, D Modi
STUDY QUESTION: What is the effect of latent genital tuberculosis (GTB) on ovarian reserve in infertile women? SUMMARY ANSWER: Women with latent GTB have lower ovarian reserves and yield lower numbers of oocytes in IVF. WHAT IS KNOWN ALREADY: Limited evidence suggests that women with GTB may have a low ovarian reserve. Infertile women have a high incidence of latent GTB and treatment improves fertility outcomes. STUDY DESIGN, SIZE, DURATION: This prospective study from February 2013 to January 2016 compared 431 infertile women diagnosed with latent GTB (Group I) to 453 infertile women without latent GTB (Group II)...
June 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29896250/diagnostic-value-of-detection-of-serum-%C3%AE-hcg-and-ct-igg-combined-with-transvaginal-ultrasonography-in-early-tubal-pregnancy
#13
Hongyan Xin, Wenlian Liu, Ping Li
The diagnostic value of detection of serum β-human chorionic gonadotropin (β-HCG) and Chlamydia trachomatis immunoglobulin G (CT-IgG) combined with transvaginal ultrasonography in early tubal pregnancy was investigated. A total of 55 patients with early tubal pregnancy were selected as the tubal pregnancy group, while 55 subjects of normal intrauterine pregnancy were enrolled as the intrauterine pregnancy group. Transvaginal ultrasonography and quantitative detection of serum β-HCG and CT-IgG were performed for all patients, and the clinical examination results were analyzed and compared...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896242/expression-profiling-of-lipocalin-2-and-24p3-receptor-in-murine-gonads-at-different-developmental-stages
#14
Elsa De La Chesnaye, Leticia Manuel-Apolinar, Leticia Damasio, Aleida Olivares, Miguel Angel Palomino, Isis Santos, Juan Pablo Méndez
Numerous clinical studies have reported the association between high circulating levels of lipocalin-2 (LCN2) and metabolic diseases. However, only few studies have addressed sexually dimorphic, either in its circulating concentration or in its expression in other organs. To the best of our knowledge, LCN2 and the 24p3 receptor (24p3R), have not been identified in gonads; therefore, the present study analyzed their mRNA expression profile and cellular localization in gonads collected from fetal rats at 21 days post coitum, as well as from neonatal rats at 0, 2, 4, 6, 12, 20 and 30 postnatal days...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29892782/tumor-budding-and-human-chorionic-gonadotropin-%C3%AE-expression-correlate-with-unfavorable-patient-outcome-in-colorectal-carcinoma
#15
Yuji Konishi, Futoshi Kawamata, Hiroshi Nishihara, Shigenori Homma, Yasutaka Kato, Masumi Tsuda, Shinji Kohsaka, Takahiro Einama, Cheng Liu, Tadashi Yoshida, Akihisa Nagatsu, Mishie Tanino, Shinya Tanaka, Hideki Kawamura, Toshiya Kamiyama, Akinobu Taketomi
Tumor budding is thought to represent a manifestation of epithelial-to-mesenchymal transition (EMT) and it has been correlated with poor patient outcomes in colorectal cancer (CRC). Our group recently demonstrated that human chorionic gonadotropin-β (hCGβ) modulates EMT in CRC. In the current study, based on the likely relationships between tumor budding and hCGβ expression, we examined their clinicopathologic significance in CRC. Twenty-eight of 80 (35.0%) CRC showed tumor budding. Tumor budding significantly correlated with lymph node metastasis (P < 0...
June 11, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29892142/ovarian-hyperstimulation-syndrome-a-narrative-review-of-its-pathophysiology-risk-factors-prevention-classification-and-management
#16
REVIEW
Bahia Namavar Jahromi, Mohammad Ebrahim Parsanezhad, Zahra Shomali, Pardis Bakhshai, Mahshid Alborzi, Najmeh Moin Vaziri, Zahra Anvar
Ovarian hyperstimulation syndrome (OHSS) is a serious complication of ovulation induction that usually occurs after gonadotropin stimulation, followed by human chorionic gonadotropin administration, for infertility treatment. The existing knowledge about the pathophysiology, risk factors, and primary and secondary methods for the prevention of OHSS is reviewed in this manuscript. The clinical manifestations and characteristics of mild, moderate, severe, and critical forms of the syndrome are defined. The methods of handling affected cases as outpatient or in-hospital management methods as well as indications for hospitalization are summarized in this review...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29891843/establishment-of-a-novel-mouse-xenograft-model-of-human-uterine-leiomyoma
#17
Yusuke Suzuki, Masaaki Ii, Takashi Saito, Yoshito Terai, Yasuhiko Tabata, Masahide Ohmichi, Michio Asahi
Uterine leiomyoma is the most common benign tumour in women, and an appropriate animal model for leiomyoma would be useful for exploring new therapeutic strategies. Therefore, we have been challenged to develop a new simple mouse model for human leiomyoma. Leiomyoma tissues were harvested from myomas resected by different surgical procedures with or without gonadotropin-releasing hormone agonist (GnRHa) treatment and were subcutaneously implanted into BALB/c nude mice with an estradiol/progesterone-releasing pellet...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29891458/-effect-of-gnrha-therapy-following-conservative-laparoscopic-surgery-for-endometriosis-on-clinical-pregnant-rate-in-patients-with-endometriosis-associated-infertility
#18
Li-Qing He, Xu-Zi Cai, Yan Wang, Xue-Feng Wang
OBJECTIVE: To investigate the impact of conservative laparoscopic surgery for endometriosis with postoperative gonadotropin-releasing hormone agonist (GnRHa) therapy on the pregnancy outcomes in patients with endometriosis-associated infertility. METHODS: The clinical data were collected from the patients with endometriosis-associated infertility undergoing conservative laparoscopic surgery in our department between January, 2011 and December, 2016. The patients were divided into laparoscopic surgery only group (without any other treatments) and postoperative GnRha therapy group, and the pregnancy outcomes were compared between the two groups at different time points during the follow-up...
May 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29890865/impact-of-stimulation-duration-and-gonadotropin-type-on-the-incidence-of-premature-progesterone-elevation-a-retrospective-analysis-of-the-ensure-data
#19
Barbara Lawrenz, Jianmin Long, Dominic Stoop, Irine Missou, Human Fatemi
Elevated progesterone levels on the day of trigger negatively impact the outcome of assisted reproductive technique (ART) treatment and forced ovarian stimulation might be a cause of progesterone elevation during ovarian stimulation. To analyze the impact of forced and prolonged stimulation on the progesterone elevation, this data analysis from the Ensure study compared hormonal stimulation with corifollitropin alpha (CFA)-only with CFA plus recombinant (rec) follicle-stimulating hormone (FSH) after day 8 (CFA-plus group) of ovarian stimulation...
June 12, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29889764/long-term-outcomes-of-elagolix-in-women-with-endometriosis-results-from-two-extension-studies
#20
Eric Surrey, Hugh S Taylor, Linda Giudice, Bruce A Lessey, Mauricio S Abrao, David F Archer, Michael P Diamond, Neil P Johnson, Nelson B Watts, J Chris Gallagher, James A Simon, Bruce R Carr, W Paul Dmowski, Nicholas Leyland, Sukhbir S Singh, Tomasz Rechberger, Sanjay K Agarwal, W Rachel Duan, Brittany Schwefel, James W Thomas, Paul M Peloso, Juki Ng, Ahmed M Soliman, Kristof Chwalisz
OBJECTIVE: To evaluate the efficacy and safety of elagolix, an oral, nonpeptide gonadotropin-releasing hormone antagonist, over 12 months in women with endometriosis-associated pain. METHODS: Elaris Endometriosis (EM)-III and -IV were extension studies that evaluated an additional 6 months of treatment after two 6-month, double-blind, placebo-controlled phase 3 trials (12 continuous treatment months) with two elagolix doses (150 mg once daily and 200 mg twice daily)...
June 6, 2018: Obstetrics and Gynecology
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