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Nanofiber scaffold

F Azizi, H R Jalil, Z Nasiri, J Moshtaghian, F Esmaeili, A Doostmohammadi, L Shabani, E Ebrahimie
Tissue engineering, as a novel transplantation therapy, aims to create biomaterial scaffolds resembling the extracellular matrix in order to regenerate the damaged tissues. Adding bioactive factors to the scaffold would improve cell-tissue interactions. In this study, the effect of chitosan poly vinyl alcohol nanofibers containing carbon nanotube scaffold with or without active bioglass (BG+ /BG- ), in combination with neonatal rat brain extract (NRBE) on cell viability, proliferation and neural differentiation of P19 embryonic carcinoma (EC) stem cells was investigated...
June 14, 2018: Journal of Tissue Engineering and Regenerative Medicine
Indrakumar Janani, Rachita Lakra, Manikantan Syamala Kiran, Purna Sai Korrapati
Cancer nanomedicine has emerged as a revolution in the last decade opening up promising strides for the cancer treatment. The major challenge in these therapeutic approaches resides in the failure of clinical trials owing to the immunological cancer microenvironment. Therefore, the success of next generation nanomedicine depends on tunable physicochemical nanomaterial design and corresponding clinical trials by integrating targeted delivery with mitigated toxicity. The present study deals with the fabrication of nanofibrous scaffold impregnated with molybdenum nanoparticles for targeted skin cancer therapeutics...
September 2018: Journal of Trace Elements in Medicine and Biology
Coline Pinese, Junquan Lin, Ulla Milbreta, Mingqiang Li, Yucai Wang, Kam W Leong, Sing Yian Chew
A low toxicity and efficient delivery system is needed to deliver small interfering RNAs (siRNA) in vitro and in vivo. The use of mesoporous silica nanoparticles (MSN) is becoming increasingly common due to its biocompatibility, tunable pore size and customizable properties. However, bolus delivery of siRNA/MSN complexes remains suboptimal, especially when a sustained and long-term administration is required. Here, we utilized electrospun scaffolds for sustained delivery of siRNA/MSN-PEI through surface adsorption and nanofiber encapsulation...
June 12, 2018: Acta Biomaterialia
Veronica Zubillaga, Asier M Salaberria, Teodoro Palomares, Ana Alonso-Varona, Sujit Kootala, Jalel Labidi, Susana C M Fernandes
The precise role and value of incorporating nanoforms in biologically active matrices for medical applications is not known. In our current work, we incorporate two chitin nanoforms (i.e., nanocrystals or nanofibers) into Genipin-chitosan crosslinked matrices. These materials were studied as 2D films and 3D porous scaffolds to assess their potential as primary support and guidance for stem cells in tissue engineering and regenerative medicine applications. The incorporation of either nanoforms in these 2D and 3D materials reveals significantly better swelling properties and robust mechanical performance in contrast to nanoform-free chitosan matrices...
June 11, 2018: Biomacromolecules
Gu Cheng, Yuming Du, Xiao Ma, Junmei Li, Yuet Cheng, Yan Cao, Ziming Wang, Xiaowen Shi, Hongbing Deng, Zubing Li
Platelet-rich plasma (PRP) is used in therapy for bone tissue repair because an abundance of osteogenesis-related growth factors can be released from the concentrated platelets. However, its clinical use is limited because growth factors, temporally released from PRP, are degraded rapidly. This study aimed to incorporate PRP-derived growth factors into SF/PCL/PVA nanofibers by coaxial electrospinning to determine the release profiles of growth factors and how the presence of these growth factors enhances the osteogenic abilities of the nanofibers...
June 7, 2018: International Journal of Pharmaceutics
Habib Bagheri, Faranak Manshaei, Omid Rezvani
Three-dimensional (3D) polyamide scaffolds were fabricated by applying a solvent bath as the collecting element. Electrospun nanofibers were immersed into the solvent bath to give a material with a laminated 3D texture. In parallel, 2D nanofibers were synthesized and utilized as microextractive phases in a needle trap device to compare the capabilities of 2D and 3D materials in terms of headspace extraction of various chlorobenzenes (chlorobenzene, 1,2-dichlorobenzene, 1,4-dichlorobenzene, 1,2,4-trichlorobenzene and 1,2,3,4-tetrachlorobenzene)...
June 8, 2018: Mikrochimica Acta
Wei-Wen Hu, Zhe-Chen Hu
In this study, nanofibrous scaffolds were used for in situ transfection application. Polyethylenimine (PEI)/DNA complexes adsorbed to alginate nanofibers, so the more alginate fibers resulted in the higher transfection efficiency. However, alginate was not favorable for cell adhesion. Therefore, poly (ε‑caprolactone) (PCL) nanofibers were electrospun with alginate to improve biocompatibility. The in situ transfection results demonstrated that although the incorporated PCL fibers effectively improved cell morphology, the bioactivity and proliferation rates of surface cells were not significantly increased due to the high ratio of alginate fibers...
June 5, 2018: International Journal of Biological Macromolecules
Roqia Ashraf, Hasham S Sofi, Aijaz Malik, Mushtaq A Beigh, Rabia Hamid, Faheem A Sheikh
Electrospinning a versatile and the most preferred technique for the fabrication of nanofibers has revolutionized by opening unlimited avenues in biomedical fields. Presently, the simultaneous functionalization and/or post-modification of as-spun nanofibers with biomolecules has been explored, to serve the distinct goals in the aforementioned field. Starch is one of the most abundant biopolymers on the earth. Besides, being biocompatible and biodegradable in nature, it has unprecedented properties of gelatinization and retrogradation...
June 8, 2018: Applied Biochemistry and Biotechnology
Barbora East, Martin Plencner, Martin Kralovic, Michala Rampichova, Vera Sovkova, Karolina Vocetkova, Martin Otahal, Zbynek Tonar, Yaroslav Kolinko, Evzen Amler, Jiri Hoch
Purpose: Incisional hernia repair is an unsuccessful field of surgery, with long-term recurrence rates reaching up to 50% regardless of technique or mesh material used. Various implants and their positioning within the abdominal wall pose numerous long-term complications that are difficult to treat due to their permanent nature and the chronic foreign body reaction they trigger. Materials mimicking the 3D structure of the extracellular matrix promote cell adhesion, proliferation, migration, and differentiation...
2018: International Journal of Nanomedicine
Elena A Silantyeva, Wafaa Nasir, Jacqueline Carpenter, Olivia Manahan, Matthew L Becker, Rebecca K Willits
Substrates for embryonic stem cell culture are typified by poorly defined xenogenic, whole proteins or cellular components that are difficult and expensive to generate, characterize, and recapitulate. Herein, the generation of well-defined scaffolds of Gly-Tyr-Ile-Gly-Ser-Arg (GYIGSR) peptide-functionalized poly(ε-caprolactone) (PCL) aligned nanofibers are used to accelerate the neural lineage commitment and differentiation of D3 mouse embryonic stem cells (mESCs). Gene expression trends and immunocytochemistry analysis were similar to laminin-coated glass, and indicated an earlier differentiation progression than D3 mESCs on laminin...
June 4, 2018: Acta Biomaterialia
Jing Wang, Lingling Tian, Liumin He, Nuan Chen, Seeram Ramakrishna, Kwok-Fai So, Xiumei Mo
Nerve regeneration is a serious clinical challenge following peripheral nerve injury. Lycium barbarum polysaccharide (LBP) is the major component of wolfberry extract, which has been shown to be neuroprotective and promising in nerve recovery in many studies. Electrospun nanofibers, especially core-shell structured nanofibers being capable of serving as both drug delivery system and tissue engineering scaffolds, are well known to be suitable scaffolds for regeneration of peripheral nerve applications. In this study, LBP was incorporated into core-shell structured nanofibrous scaffolds via coaxial electrospinning...
June 6, 2018: Scientific Reports
Ryan J Miller, Cheook Y Chan, Arjun Rastogi, Allison M Grant, Christina M White, Nicole Bette, Nicholas J Schaub, Joseph M Corey
A promising component of biomaterial constructs for neural tissue engineering are electrospun fibers, which differentiate stem cells and neurons as well as direct neurite growth. However, means of protecting neurons, glia, and stem cells seeded on electrospun fibers between lab and surgical suite have yet to be developed. Here we report an effort to accomplish this using cell-encapsulating hydrogel fibers made by interfacial polyelectrolyte complexation (IPC). IPC-hydrogel fibers were created by interfacing acid-soluble chitosan (AsC) and cell-containing alginate and spinning them on bundles of aligned electrospun fibers...
June 3, 2018: Journal of Biomaterials Science. Polymer Edition
Ming Yan, Phillip L Lewis, Ramille N Shah
3D-printing has expanded our ability to produce reproducible and more complex scaffold architectures for tissue engineering applications. In order to enhance the biological response within these 3D printed scaffolds incorporating nanostructural features and/or specific biological signaling may be an effective means to optimize tissue regeneration. Peptides Amphiphiles (PAs) are a versatile supramolecular biomaterial with tailorable nanostructural and biochemical features. PAs are widely used in tissue engineering applications such as angiogenesis, neurogenesis, and bone regeneration...
May 31, 2018: Biofabrication
Linpeng Fan, Jing-Liang Li, Zengxiao Cai, Xun-Gai Wang
Continuous evolution of tissue engineering scaffolds has been driven by the desire to recapitulate structural features and functions of the natural extracellular matrix (ECM). However, it is still an extreme challenge to create a three-dimensional (3D) scaffold with both aligned nanofibers and aligned interconnected macrochannels to mimic the ECM of anisotropic tissues. Here, we develop a facile strategy to create such a scaffold composed of oriented nanofibers and interconnected macrochannels in the same direction, with various natural polymers typically used for tissue regeneration...
May 30, 2018: ACS Nano
Shenglian Yao, Shukui Yu, Zheng Cao, Yongdong Yang, Xing Yu, Hai-Quan Mao, Lu-Ning Wang, Xiaodan Sun, Lingyun Zhao, Xiumei Wang
Background: Designing novel biomaterials that incorporate or mimic the functions of extracellular matrix to deliver precise regulatory signals for tissue regeneration is the focus of current intensive research efforts in tissue engineering and regenerative medicine. Methods and results: To mimic the natural environment of the spinal cord tissue, a three-dimensional hierarchically aligned fibrin hydrogel (AFG) with oriented topography and soft stiffness has been fabricated by electrospinning and a concurrent molecular self-assembling process...
2018: International Journal of Nanomedicine
Marta Diaz Caballero, Susanna Navarro, Isabel Fuentes, Francesc Teixidor, Salvador Ventura
Nature provides copious examples of self-assembling supramolecular nanofibers. Among them, amyloid structures have found amazing applications as advanced materials in fields such as biomedicine and nanotechnology. Prions are a singular subset of proteins able to switch between a soluble conformation and an amyloid state. The ability to transit between these two conformations is encoded in the so-called prion domains (PrDs), which are long and disordered regions of low complexity, enriched in polar and uncharged amino acids such as Gln, Asn, Tyr, Ser and Gly...
May 29, 2018: ACS Nano
Xiujuan Zhao, Liangyu Zhou, Qingtao Li, Qingxia Zou, Chang Du
Inspired by the natural extracellular matrix, the organic-inorganic composite nanofibers are promising scaffolds for bone tissue engineering. Chitosan-based nanofibers are widely used as bone tissue engineering scaffolds with good biocompatibility but pungent solvents are frequently used for its processing. Carboxymethyl chitosan (CMCS), a water-soluble derivative of chitosan, has better biodegradability and bioactivity which allows CMCS to chelate Ca2+ and induce the deposition of apatite. Moreover, with water as solvent, CMCS nanofibers avoid the acidic salt removal comparing to electrospun-chitosan...
September 1, 2018: Carbohydrate Polymers
Zhang Zhengshi, Ding Zhaozhao, Huang Jiwei, Qin Jianzhong, Shen Yixin, Zhang Feng, Zuo Baoqi
Silk porous scaffolds have shown promising applications in tissue regenerations as cellular scaffolds to incorporate cells in vitro and in vivo, and facilitate cell proliferation and production of extracellular matrix. It remains strong needs to optimize the microstructures and performances of silk scaffolds for better biocompatibility. Here, a green process was developed to form water-insoluble scaffolds. Repeated freezing-dissolving procedures and silk nanofibers were introduced to tune the performances of the scaffolds, resulting in amorphous conformations and nanofibrous structures...
May 24, 2018: International Journal of Biological Macromolecules
Rongjun Li, Yali Ma, Yan Zhang, Mei Zhang, Dahui Sun
Nanofibers fabricated by electrospinning simulate the extracellular matrix of bone cells and so researchers have taken a keen interest in them for regenerating bone tissue. The aim of this study was to fabricate ideal Zein/PLLA nanofibers by coaxial electrospinning and to load them with bone morphogenetic protein 2 (BMP-2) and dexamethasone (DEX) for dual controlled-release for bone tissue engineering applications. Morphology, surface hydrophilicity and core-shell construction were analyzed by environmental scanning electron microscopy (SEM), water contact angle and transmission electron microscopy (TEM)...
May 19, 2018: Colloids and Surfaces. B, Biointerfaces
Jing Wang, Lingling Tian, Baiwen Luo, Seeram Ramakrishna, Dan Kai, Xian Jun Loh, In Hong Yang, G Roshan Deen, Xiumei Mo
Antioxidant is critical for the successful of nerve tissue regeneration, and biomaterials with antioxidant activity might be favorable for peripheral nerve repair. Lignin, a biopolymer from wood with excellent antioxidant properties, is still "unexplored" as biomaterials. To design an antioxidative bioscaffold for nerve regeneration, here we synthesized lignin-polycaprolactone (PCL) copolymers via solvent free ring-opening polymerization (ROP). Then such lignin-PCL copolymers were incorporated with PCL and engineered into nanofibrous scaffolds for supporting the growth of neuron and Schwann cell...
May 12, 2018: Colloids and Surfaces. B, Biointerfaces
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