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Nanofiber scaffold

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https://www.readbyqxmd.com/read/28198135/hierarchically-ordered-polymer-nanofiber-shish-kebabs-as-a-bone-scaffold-material
#1
Xi Chen, Sarah E Gleeson, Tony Yu, Nasreen Khan, Robert W Yucha, Michele Marcolongo, Christopher Y Li
The ideal bone scaffold harnesses the body's ability to regenerate bone in critical size defects. A potential strategy to design the ideal bone scaffold is to mimic the natural structure of bone at the molecular level. The orientation and spatial distribution of nanocrystals in the organic matrix are two important and distinctive structural characteristics associated with natural bone. There has yet to be a synthetic system or scaffold that is able to control both the spatial distribution and orientation of the HAP crystalline structure...
February 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28192154/electrospun-polyurethane-nanofiber-scaffolds-with-ciprofloxacin-oligomer-effect-on-drug-release-and-cell-attachment-versus-free-drug
#2
Meghan Ee Wright, Ian C Parrag, Meilin Yang, J Paul Santerre
An electrospun degradable polycarbonate urethane (PCNU) nanofiber scaffold loaded with antibiotic was investigated in terms of antibacterial efficacy and cell compatibility for potential use in gingival tissue engineering. Antimicrobial oligomer (AO), a compound which consists of two molecules of ciprofloxacin (CF) covalently bound via hydrolysable linkages to triethylene glycol (TEG), was incorporated via a one-step blend electrospinning process using a single solvent system at 7 and 15% w/w equivalent CF with respect to the PCNU...
February 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28187394/nano-on-micro-fibrous-extracellular-matrices-for-scalable-expansion-of-human-es-ips-cells
#3
Li Liu, Ken-Ichiro Kamei, Momoko Yoshioka, Minako Nakajima, Junjun Li, Nanae Fujimoto, Shiho Terada, Yumie Tokunaga, Yoshie Koyama, Hideki Sato, Kouichi Hasegawa, Norio Nakatsuji, Yong Chen
Human pluripotent stem cells (hPSCs) hold great potential for industrial and clinical applications. Clinical-grade scaffolds and high-quality hPSCs are required for cell expansion as well as easy handling and manipulation of the products. Current hPSC culture methods do not fulfill these requirements because of a lack of proper extracellular matrices (ECMs) and cell culture wares. We developed a layered nano-on-micro fibrous cellular matrix mimicking ECM, named "fiber-on-fiber (FF)" matrix, which enables easy handling and manipulation of cultured cells...
February 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28183642/magnetic-nanoparticle-loaded-electrospun-polymeric-nanofibers-for-tissue-engineering
#4
Heng Zhang, JiYi Xia, XianLun Pang, Ming Zhao, BiQiong Wang, LingLin Yang, HaiSu Wan, JingBo Wu, ShaoZhi Fu
Magnetic nanoparticles have been one of the most attractive nanomaterials for various biomedical applications including magnetic resonance imaging (MRI), diagnostic contrast enhancement, magnetic cell separation, and targeted drug delivery. Three-dimensional (3-D) fibrous scaffolds have broad application prospects in the biomedical field, such as drug delivery and tissue engineering. In this work, a novel three-dimensional composite membrane composed of the tri-block copolymer poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) and magnetic iron oxide nanoparticles (Fe3O4 NPs) were fabricated using electrospinning technology...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183612/controlled-surface-morphology-and-hydrophilicity-of-polycaprolactone-toward-human-retinal-pigment-epithelium-cells
#5
Saleheh Shahmoradi, Fatemeh Yazdian, Fatemeh Tabandeh, Zahra-Soheila Soheili, Ashraf Sadat Hatamian Zarami, Mona Navaei-Nigjeh
Applying scaffolds as a bed to enhance cell proliferation and even differentiation is one of the treatment of retina diseases such as age-related macular degeneration (AMD) which deteriorating photoreceptors and finally happening blindness. In this study, aligned polycaprolactone (PCL) nanofibers were electrospun and at different conditions and their characteristics were measured by scanning electron microscope (SEM) and contact angle. Response surface methodology (RSM) was used to optimize the diameter of fabricated nanofibers...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28169354/three-dimensional-aligned-nanofibers-hydrogel-scaffold-for-controlled-non-viral-drug-gene-delivery-to-direct-axon-regeneration-in-spinal-cord-injury-treatment
#6
Lan Huong Nguyen, Mingyong Gao, Junquan Lin, Wutian Wu, Jun Wang, Sing Yian Chew
Spinal cord injuries (SCI) often lead to persistent neurological dysfunction due to failure in axon regeneration. Unfortunately, currently established treatments, such as direct drug administration, do not effectively treat SCI due to rapid drug clearance from our bodies. Here, we introduce a three-dimensional aligned nanofibers-hydrogel scaffold as a bio-functionalized platform to provide sustained non-viral delivery of proteins and nucleic acid therapeutics (small non-coding RNAs), along with synergistic contact guidance for nerve injury treatment...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28159718/mechanical-function-near-defects-in-an-aligned-nanofiber-composite-is-preserved-by-inclusion-of-disorganized-layers-insight-into-meniscus-structure-and-function
#7
Sonia Bansal, Sai Mandalapu, Céline Aeppli, Feini Qu, Spencer E Szczesny, Robert L Mauck, Miltiadis H Zgonis
: The meniscus is comprised of circumferentially aligned fibers that resist the tensile forces within the meniscus (i.e., hoop stress) that develop during loading of the knee. Although these circumferential fibers are severed by radial meniscal tears, tibial contact stresses do not increase until the tear reaches ∼90% of the meniscus width, suggesting that the severed circumferential fibers still bear load and maintain the mechanical functionality of the meniscus. Recent data demonstrates that the interfibrillar matrix can transfer strain energy to disconnected fibrils in tendon fascicles...
January 31, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28134776/bioactive-polymeric-materials-for-tissue-repair
#8
Diane R Bienek, Wojtek Tutak, Drago Skrtic
Bioactive polymeric materials based on calcium phosphates have tremendous appeal for hard tissue repair because of their well-documented biocompatibility. Amorphous calcium phosphate (ACP)-based ones additionally protect against unwanted demineralization and actively support regeneration of hard tissue minerals. Our group has been investigating the structure/composition/property relationships of ACP polymeric composites for the last two decades. Here, we present ACP's dispersion in a polymer matrix and the fine-tuning of the resin affects the physicochemical, mechanical, and biological properties of ACP polymeric composites...
January 26, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28130867/in-vivo-guided-vascular-regeneration-with-a-non-porous-elastin-like-polypeptide-hydrogel-tubular-scaffold
#9
Atsushi Mahara, Kristi L Kiick, Tetsuji Yamaoka
Herein, we demonstrate a new approach for small-caliber vascular reconstruction using a non-porous elastin-like polypeptide hydrogel tubular scaffold, based on the concept of guided vascular regeneration (GVR). The scaffolds are composed of elastin-like polypeptide, (Val-Pro-Gly-Ile-Gly)n , for compliance matching and antithrombogenicity and an Arg-Gly-Asp (RGD) motif for connective tissue regeneration. When the polypeptide was mixed with an aqueous solution of β-[Tris(hydroxymethyl)phosphino]propionic acid at 37°C, the polypeptide hydrogel was rapidly formed...
January 28, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28128919/carbon-nanofiber-polycaprolactone-mineralized-hydroxyapatite-nanofibrous-scaffolds-for-potential-orthopedic-applications
#10
Shinyjoy Elangomannan, Kavitha Louis, Bhagya Mathi Dharmaraj, Venkata Saravanan Kandasamy, Kannan Soundarapandian, Dhanaraj Gopi
Hydroxyapatite (Ca10 (PO4)6(OH)2, HAP), a multimineral substituted calcium phosphate is one of the most substantial bone mineral component that has been widely used as bone replacement materials because of its bioactive and biocompatible properties. However, the use of HAP as bone implants is restricted due to its brittle nature and poor mechanical properties. To overcome this defect and to generate suitable bone implant material, HAP is combined with biodegradable polymer (polycaprolactone, PCL). To enhance the mechanical property of the composite, carbon nanofibers (CNF) is incorporated to the composite, which has long been considered for hard and soft tissue implant due to its exceptional mechanical and structural properties...
February 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28125204/fenugreek-incorporated-silk-fibroin-nanofibers-a-potential-antioxidant-scaffold-for-enhanced-wound-healing
#11
Sowmya Selvaraj, Nishter Nishad Fathima
Free radicals are generated by various biochemical pathways in the living system, causing severe oxidative damage to the biomolecules leading to adverse disease conditions. Hence, there is an increasing interest in antioxidant studies for preventing the effects of these free radicals. Herein, we propose a novel electrospun scaffold with antioxidant properties that can be used as wound healing material. Fenugreek, a natural antioxidant incorporated silk fibroin nanofiber, was prepared in four different ratios by the co-electrospinning method...
February 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28124460/skin-regeneration-stimulation-the-role-of-pcl-platelet-gel-nanofibrous-scaffold
#12
Parviz Ranjbarvan, Masoud Soleimani, Ali Samadi Kuchaksaraei, Jafar Ai, Reza Faridi Majidi, Javad Verdi
Skin is the largest organ of the human body. Thus far, tissue engineering of skin has developed rapidly and has used many types of growth factors and nanofibrous scaffolds. In this study, we differentiated neonate keratinocytes for epithelialization on the polycaprolactone-Platelet gel (PCL-PG) scaffold. Fabricated PCL nanofibers prepared by electrospinning technology and coated by platelet gel. Subsequently, the structure of the scaffold was evaluated by SEM, FTIR-ATR, contact angle and tensile test assays...
January 25, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28120428/influence-of-random-and-oriented-electrospun-fibrous-poly-lactic-co-glycolic-acid-scaffolds-on-neural-differentiation-of-mouse-embryonic-stem-cells
#13
Laura E Sperling, Karina P Reis, Laura G Pozzobon, Carolina S Girardi, Patricia Pranke
Engineering neural tissue by combining biodegradable materials, cells and growth factors is a promising strategy for the treatment of central and peripheral nervous system injuries. In this study, neural differentiation of mouse embryonic stem cells (mESCs) was investigated in combination with three dimensional (3D) electrospun nanofibers as a substitute for the extracellular matrix (ECM). Nano/microfibrous poly(lactic-co-glycolic acid) (PLGA) 3D scaffolds were fabricated through electrospinning and characterized...
January 25, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28118541/non-woven-polymer-nanofiber-coatings-that-inhibit-quorum-sensing-in-staphylococcus-aureus-toward-new-non-bactericidal-approaches-to-infection-control
#14
Michael J Kratochvil, Tian Yang, Helen E Blackwell, David M Lynn
We report the fabrication and biological evaluation of non-woven polymer nanofiber coatings that inhibit quorum sensing (QS) and virulence in the human pathogen Staphylococcus aureus. Our results demonstrate that macrocyclic peptide 1, a potent synthetic non-bactericidal quorum sensing inhibitor (QSI) in S. aureus, can be loaded into degradable polymer nanofibers by electrospinning, and that this approach can deposit QSI-loaded nanofiber coatings onto model non-woven mesh substrates. QSI was released over ~3 weeks when these materials were incubated in physiological buffer, and retained its biological activity and strongly inhibited agr-based QS in a GFP reporter strain of S...
January 24, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28117963/chitosan-intercalated-montmorillonite-poly-vinyl-alcohol-nanofibers-as-a-platform-to-guide-neuron-like-differentiation-of-human-dental-pulp-stem-cells
#15
Hatef Ghasemi Hamidabadi, Zahra Rezvani, Maryam Nazm Bojnordi, Haji Shirinzadeh, Alexander M Seifalian, Mohammad Taghi Joghataei, Mojgan Razaghpour, Abbas Alibakhshi, Abolfazl Yazdanpanah, Maryam Salimi, Masoud Mozafari, Aleksandra M Urbanska, Rui L Reis, Subhas C Kundu, Mazaher Gholipourmalekabadi
In this study, we present a novel chitosan-intercalated montmorillonite/Poly(Vinyl alcohol) (OMMT/PVA) nanofibrous mesh as a microenvironment for guiding differentiation of human dental pulp stem cells (hDPSCs) toward neuron-like cells. The OMMT was prepared through ion exchange reaction between the montmorillonite (MMT) and chitosan. The PVA solutions containing various concentrations of OMMT were electrospun to form 3-D OMMT-PVA nanofibrous meshes. The biomechanical and biological characteristics of the nanofibrous meshes were evaluated by ATR-FTIR, XRD, SEM, MTT, LDH specific activity, contact angle, and DAPI staining...
January 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28109812/chitosan-as-a-vehicle-for-growth-factor-delivery-various-preparations-and-their-applications-in-bone-tissue-regeneration
#16
REVIEW
Jayachandran Venkatesan, Sukumaran Anil, Se-Kwon Kim, Min Suk Shim
The replacement of conventional autografts and allografts by bone fragments constructed from alternate materials, cells, and molecules (growth factors, drugs, etc.) is an exciting prospect in the field of bone tissue engineering. Bone morphogenetic protein-2 (BMP-2) is a growth factor that has been extensively studied from this point of view. This review analyzes the relevance of chitosan and its derivatives and composites with various materials such as ceramics, heparin, silica, stem cells, titanium implants, etc...
January 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28097017/study-of-myoblast-differentiation-using-multi-dimensional-scaffolds-consisting-of-nano-and-micropatterns
#17
Sung Ho Cha, Hyun Jong Lee, Won-Gun Koh
BACKGROUND: The topographical cue is major influence on skeletal muscle cell culture because the structure is highly organized and consists of long parallel bundles of multinucleated myotubes that are formed by differentiation and fusion of myoblast satellite cells. In this technical report, we fabricated a multiscale scaffold using electrospinning and poly (ethylene glycol) (PEG) hydrogel micropatterns to monitor the cell behaviors on nano- and micro-alignment combined scaffolds with different combinations of angles...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28093942/self-assembling-peptide-nanostructures-on-aligned-poly-lactide-co-glycolide-nanofibers-for-the-functional-regeneration-of-sciatic-nerve
#18
Manasa Nune, Anuradha Subramanian, Uma Maheswari Krishnan, Suraj Sasidhara Kaimal, Swaminathan Sethuraman
AIM: Regeneration of functional peripheral nerve tissue at critical-sized defect requires extracellular matrix analogs impregnated with appropriate biosignals to regulate the cell fate process and subsequent tissue progression. The aim of the study was to develop electrospun aligned nanofibers as architectural analogs integrated with RADA16-I-BMHP1 as biofunctional peptides. MATERIALS & METHODS: Aligned poly(lactide-co-glycolide) (PLGA)-RADA16-I-BMHP1 nanofibers were fabricated and characterized for their in vitro potential using rat Schwann cell line and in vivo potential using a 10 mm sciatic nerve transection rat model...
January 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28093364/fabrication-of-nanofibrous-electrospun-scaffolds-from-a-heterogeneous-library-of-co-and-self-assembling-peptides
#19
Mahboubeh Maleki, Antonino Natalello, Raffaele Pugliese, Fabrizio Gelain
: Self-assembling (SAPs) and co-assembling peptides (CAPs) are driving increasing enthusiasm as synthetic but biologically inspired biomaterials amenable of easy functionalization for regenerative medicine. On the other hand, electrospinning (ES) is a versatile technique useful for tailoring the nanostructures of various biomaterials into scaffolds resembling the extracellular matrices found in organs and tissues. The synergistic merging of these two approaches is a long-awaited advance in nanomedicine that has not been deeply documented so far...
January 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28087448/fabrication-and-characterization-of-electrospun-cellulose-nano-hydroxyapatite-nanofibers-for-bone-tissue-engineering
#20
Chenghong Ao, Yan Niu, Ximu Zhang, Xu He, Wei Zhang, Canhui Lu
Nanofibrous scaffolds from cotton cellulose and nano-hydroxyapatite (nano-HA) were electrospun for bone tissue engineering. The solution properties of cellulose/nano-HA spinning dopes and their associated electrospinnability were characterized. Morphological, thermal and mechanical properties of the electrospun cellulose/nano-HA nanocomposite nanofibers (ECHNN) were measured and the biocompatibility of ECHNN with human dental follicle cells (HDFCs) was evaluated. Scanning electron microscope (SEM) images indicated that the average diameter of ECHNN increased with a higher nano-HA loading and the fiber diameter distributions were well within the range of natural ECM (extra cellular matrix) fibers (50-500nm)...
April 2017: International Journal of Biological Macromolecules
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