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Cardiac output; haemodynamic;

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https://www.readbyqxmd.com/read/29728410/what-is-the-normal-haemodynamic-response-to-passive-leg-raise-a-study-of-healthy-volunteers
#1
Mohammed H Elwan, Ashraf Roshdy, Joseph A Reynolds, Eman M Elsharkawy, Salah M Eltahan, Timothy J Coats
OBJECTIVE: Passive leg raise (PLR) is used as self-fluid challenge to optimise fluid therapy by predicting preload responsiveness. However, there remains uncertainty around the normal haemodynamic response to PLR with resulting difficulties in application and interpretation in emergency care. We aim to define the haemodynamic responses to PLR in spontaneously breathing volunteers using a non-invasive cardiac output monitor, thoracic electrical bioimpedance, TEB (PLR-TEB). METHODS: We recruited healthy volunteers aged 18 or above...
May 4, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29721645/midazolam-increases-preload-dependency-during-endotoxic-shock-in-rabbits-by-affecting-venous-vascular-tone
#2
Jianxiao Chen, Tao Yu, Federico Longhini, Xiwen Zhang, Songqiao Liu, Ling Liu, Yi Yang, Haibo Qiu
BACKGROUND: Septic patients often require sedation in intensive care unit, and midazolam is one of the most frequently used sedatives among them. But the interaction between midazolam and septic shock is not known. The aim of this study is to investigate the effects of midazolam on preload dependency in an endotoxic shock model by evaluating systemic vascular tone and cardiac function. METHODS: Eighteen rabbits were randomly divided into three groups: Control group, MID1 group and MID2 group...
May 2, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29713818/right-ventriculo-arterial-uncoupling-and-impaired-contractile-reserve-in-obese-patients-with-unexplained-exercise-intolerance
#3
Colm McCabe, Rudolf K F Oliveira, Farbod Rahaghi, Mariana Faria-Urbina, Luke Howard, Richard G Axell, Andrew N Priest, Aaron B Waxman, David M Systrom
BACKGROUND: Right ventricular (RV) dysfunction and heart failure with preserved ejection fraction may contribute to exercise intolerance in obesity. To further define RV exercise responses, we investigated RV-arterial coupling in obesity with and without development of exercise pulmonary venous hypertension (ePVH). METHODS: RV-arterial coupling defined as RV end-systolic elastance/pulmonary artery elastance (Ees/Ea) was calculated from invasive cardiopulmonary exercise test data in 6 controls, 8 obese patients without ePVH (Obese-ePVH) and 8 obese patients with ePVH (Obese+ePVH) within a larger series...
April 30, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29706899/development-of-the-human-placenta-and-fetal-heart-synergic-or-independent
#4
REVIEW
Graham J Burton, Eric Jauniaux
The placenta is the largest fetal organ, and toward the end of pregnancy the umbilical circulation receives at least 40% of the biventricular cardiac output. It is not surprising, therefore, that there are likely to be close haemodynamic links between the development of the placenta and the fetal heart. Development of the placenta is precocious, and in advance of that of the fetus. The placenta undergoes considerable remodeling at the end of the first trimester of pregnancy, and its vasculature is capable of adapting to environmental conditions and to variations in the blood supply received from the mother...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29695645/non-invasive-measurement-of-cardiac-output-in-children-with-repaired-coarctation-of-the-aorta-using-electrical-cardiometry-compared-to-transthoracic-doppler-echocardiography
#5
Luis Altamirano-Diaz, Eva Welisch, Adam A Dempsey, Teresa Sohee Park, Michael Grattan, Kambiz Norozi
Objective
 To evaluate the equivalence of the ICON® electrical cardiometry (EC) haemodynamic monitor to measure cardiac output (CO) relative to transthoracic Doppler echocardiography (TTE) in paediatric patients with repaired coarctation of the aorta (CoA). 
 
 Approach
 A group of n=28 CoA patients and n=27 matched controls were enrolled. EC and TTE were performed synchronously on each participant and CO measurements compared using linear regression and Bland-Altman analysis...
April 26, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29690910/haemodynamic-outcomes-during-piston-based-mechanical-cpr-with-or-without-active-decompression-in-a-porcine-model-of-cardiac-arrest
#6
Mikkel T Steinberg, Jan-Aage Olsen, Morten Eriksen, Andres Neset, Per Andreas Norseng, Jo Kramer-Johansen, Bjarne Madsen Hardig, Lars Wik
BACKGROUND: Experimental active compression-decompression (ACD) CPR is associated with increased haemodynamic outcomes compared to standard mechanical chest compressions. Since no clinically available mechanical chest compression device is capable of ACD-CPR, we modified the LUCAS 2 (Physio-Control, Lund, Sweden) to deliver ACD-CPR, hypothesising it would improve haemodynamic outcomes compared with standard LUCAS CPR on pigs with cardiac arrest. METHODS: The modified LUCAS delivering 5 cm compressions with or without 2 cm active decompression above anatomical chest level was studied in a randomized crossover design on 19 Norwegian domestic pigs...
April 24, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29617762/pressure-gradient-vs-flow-relationships-to-characterize-the-physiology-of-a-severely-stenotic-aortic-valve-before-and-after-transcatheter-valve-implantation
#7
Nils P Johnson, Jo M Zelis, Pim A L Tonino, Patrick Houthuizen, R Arthur Bouwman, Guus R G Brueren, Daniel T Johnson, Jacques J Koolen, Hendrikus H M Korsten, Inge F Wijnbergen, Frederik M Zimmermann, Richard L Kirkeeide, Nico H J Pijls, K Lance Gould
Aims: Echocardiography and tomographic imaging have documented dynamic changes in aortic stenosis (AS) geometry and severity during both the cardiac cycle and stress-induced increases in cardiac output. However, corresponding pressure gradient vs. flow relationships have not been described. Methods and results: We recruited 16 routine transcatheter aortic valve implantations (TAVI's) for graded dobutamine infusions both before and after implantation; 0.014″ pressure wires in the aorta and left ventricle (LV) continuously measured the transvalvular pressure gradient (ΔP) while a pulmonary artery catheter regularly assessed cardiac output by thermodilution...
April 2, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29510691/a-preliminary-study-evaluating-cardiac-output-measurement-using-pressure-recording-analytical-method-pram-in-anaesthetized-dogs
#8
Angela Briganti, Flavia Evangelista, Paola Centonze, Annaliso Rizzo, Francesco Bentivegna, Antonio Crovace, Francesco Staffieri
BACKGROUND: Haemodynamic variations normally occur in anaesthetized animals, in relation to the animal status, administered drugs, sympathetic and parasympathetic tone, fluid therapy and surgical stimulus. The possibility to measure some cardiovascular parameters, such as cardiac output (CO), during anaesthesia would be beneficial for both the anaesthesia management and its outcome. New techniques for the monitoring of CO are aimed at finding methods which are non invasive, accurate and with good trending ability, which can be used in a clinical setting...
March 6, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29508407/moderate-preterm-birth-affects-right-ventricular-structure-and-function-and-pulmonary-artery-blood-flow-in-adult-sheep
#9
Marshall M Mrocki, Vivian B Nguyen, Paul Lombardo, Megan R Sutherland, Jonathan G Bensley, Ilias Nitsos, Beth J Allison, Richard Harding, Robert De Matteo, Michal Schneider, Graeme R Polglase, M Jane Black
KEY POINTS: Preterm birth occurs when the heart muscle is immature and ill-prepared for the changes in heart and lung function at birth. MRI imaging studies show differences in the growth and function of the heart of young adults born preterm, with the effects more pronounced in the right ventricle. The findings of this study, conducted in sheep, showed that following moderate preterm birth the right ventricular wall was thinner in adulthood, with a reduction in the number and size of the heart muscle cells; in addition, there was impaired blood flow in the main artery leading from the right ventricle to the lungs...
March 6, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29507790/hyperthermic-intrathoracic-chemotherapy-after-extended-pleurectomy-and-decortication-for-malignant-pleura-mesothelioma-an-observational-study-on-outcome-and-microcirculatory-changes
#10
Luca Luzzi, Federico Franchi, Annarita Dapoto, Marco Ghisalberti, Roberto Corzani, Daniele Marrelli, Luca Marchetti, Piero Paladini, Sabino Scolletta
Background: In the treatment of malignant pleural mesothelioma the Hyperthermic Intra THOracic Chemotherapy (HITHOC) can improve the efficacy of pleurectomy and decortication with a local cytotoxic effect. However its biological impact in patient's hemodynamic and microcirculatory changes were rarely investigated. Aim of this study is to describe our experience with HITHOC after pleurectomy and decortication evaluating the role of sublingual video-microscopy in assessing the microcirculatory changes in the perioperative period...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29474844/early-and-late-preeclampsia-are-characterized-by-high-cardiac-output-but-in-the-presence-of-fetal-growth-restriction-cardiac-output-is-low-insights-from-a-prospective-study
#11
Jasmine Tay, Lin Foo, Giulia Masini, Phillip R Bennett, Carmel M McEniery, Ian B Wilkinson, Christoph C Lees
BACKGROUND: Preeclampsia and fetal growth restriction are considered to be placentally mediated disorders. The clinical manifestations are widely held to relate to gestation age at onset with early- and late-onset preeclampsia considered to be phenotypically distinct. Recent studies have reported conflicting findings in relation to cardiovascular function, and in particular cardiac output, in preeclampsia and fetal growth restriction. OBJECTIVE: We conducted this study to examine the possible relation between cardiac output and peripheral vascular resistance in preeclampsia and fetal growth restriction...
May 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29469177/haemodynamic-effects-of-levosimendan-in-advanced-but-stable-chronic-heart-failure
#12
Emil Najjar, Marcus Stålhberg, Camilla Hage, Erica Ottenblad, Aristomenis Manouras, Ida Haugen Löfman, Lars H Lund
AIMS: Levosimendan improves haemodynamics in acute decompensated heart failure (HF). However, it is increasingly used for repetitive or intermittent infusions in advanced but stable chronic HF, without clear indication, selection criteria, or effect. We tested the hypotheses that (1) levosimendan improves haemodynamics in stable chronic HF and (2) that the response is dependent on baseline clinical and haemodynamic factors. METHODS AND RESULTS: Twenty-three patients [median age 56 (49-64) years, four (17%) women] with stable New York Heart Association (NYHA) III and IV HF received a single 24 h levosimendan infusion...
June 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29406186/current-concepts-of-fluid-management-in-enhanced-recovery-pathways
#13
REVIEW
R Makaryus, T E Miller, T J Gan
Perioperative fluid management impacts outcomes and plays a pivotal role in enhanced recovery pathways (ERPs). There have been major advances in understanding the effects of fluid therapy and administration during the perioperative period. Improving fluid management during this period leads to a decrease in complications, decrease in length of stay (LOS), and enhanced patient outcomes. It is important to consider preoperative and postoperative fluid management to be just as critical as intraoperative management given multiple associated benefits to the patients...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29383017/highly-potent-antioxidant-olea-europaea-l-leaf-extract-affects-carotid-and-renal-haemodynamics-in-experimental-hypertension-the-role-of-oleuropein
#14
Milan Ivanov, Una-Jovana Vajic, Nevena Mihailovic-Stanojevic, Zoran Miloradovic, Djurdjica Jovovic, Jelica Grujic-Milanovic, Danijela Karanovic, Dragana Dekanski
Haemodynamic alterations in carotid and renal arteries are associated with the severity of target organ damage in patients with hypertension. Dietary habits, such as the Mediterranean diet, regulate blood pressure and oxidative stress, thus reduce the mortality rate due to cardiovascular diseases. In this study, our aim was to evaluate the reducing activity, antioxidant capacity and metal chelating ability of standardized Olea europaea L. leaf extract (OLE), and to test its (5, 25, 50 mg/kg) acute in vivo effects, as well as oleuropein's (OP, 10 mg/kg) on oxidative stress, carotid, renal and systemic haemodynamic parameters (blood pressure, heart rate, cardiac output, peripheral resistance) in spontaneously hypertensive rats (SHR)...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29376560/inotropic-agents-and-vasodilator-strategies-for-the-treatment-of-cardiogenic-shock-or-low-cardiac-output-syndrome
#15
REVIEW
Julia Schumann, Eva C Henrich, Hellen Strobl, Roland Prondzinsky, Sophie Weiche, Holger Thiele, Karl Werdan, Stefan Frantz, Susanne Unverzagt
BACKGROUND: Cardiogenic shock (CS) and low cardiac output syndrome (LCOS) as complications of acute myocardial infarction (AMI), heart failure (HF) or cardiac surgery are life-threatening conditions. While there is a broad body of evidence for the treatment of people with acute coronary syndrome under stable haemodynamic conditions, the treatment strategies for people who become haemodynamically unstable or develop CS remain less clear. We have therefore summarised here the evidence on the treatment of people with CS or LCOS with different inotropic agents and vasodilative drugs...
January 29, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29374830/correlations-between-near-infrared-spectroscopy-perfusion-index-and-cardiac-outputs-in-extremely-preterm-infants-in-the-first-72-h-of-life
#16
Marie Janaillac, Thierry P Beausoleil, Keith J Barrington, Marie-Josée Raboisson, Oliver Karam, Mathieu Dehaes, Anie Lapointe
Haemodynamic assessment during the transitional period in preterm infants is challenging. We aimed to describe the relationships between cerebral regional tissue oxygen saturation (CrSO2 ), perfusion index (PI), echocardiographic, and clinical parameters in extremely preterm infants in their first 72 h of life. Twenty newborns born at < 28 weeks of gestation were continuously monitored with CrSO2 and preductal PI. Cardiac output was measured at H6, H24, H48, and H72. The median gestational age and birth weight were 25...
April 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29369117/does-goal-directed-haemodynamic-and-fluid-therapy-improve-peri-operative-outcomes-a-systematic-review-and-meta-analysis
#17
Matthew A Chong, Yongjun Wang, Nicolas M Berbenetz, Ian McConachie
BACKGROUND: Much uncertainty exists as to whether peri-operative goal-directed therapy is of benefit. OBJECTIVES: To discover if peri-operative goal-directed therapy decreases mortality and morbidity in adult surgical patients. DESIGN: An updated systematic review and random effects meta-analysis of randomised controlled trials. DATA SOURCES: Medline, Embase and the Cochrane Library were searched up to 31 December 2016...
January 23, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29360066/perkat-rv-first-in-vivo-data-of-a-novel-right-heart-assist-device
#18
Daniel Kretzschmar, Alexander Lauten, Harald Schubert, Sabine Bischoff, Christian Schulze, Markus W Ferrari
AIMS: Mechanical right ventricular (RV) support offers a treatment option for critically ill patients with RV failure (RVF). We developed an assist device for rapid percutaneous implantation. The aim of the present study was to investigate the implantation procedure, haemodynamic performance and possible side effects of the novel right ventricular assist device - PERKAT RV - in an animal model. METHODS AND RESULTS: The PERkutane KATheterpumptechnologie RV (PERKAT RV) device consists of a nitinol chamber covered by foil containing inflow valves...
April 6, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29325813/cardiac-function-and-exercise-adaptation-in-8-children-with-lpin1-mutations
#19
Antoine Legendre, Diala Khraiche, Phalla Ou, François-Xavier Mauvais, Marine Madrange, Anne-Sophie Guemann, Jean-Philippe Jais, Damien Bonnet, Yamina Hamel, Pascale de Lonlay
INTRODUCTION: Lipin-1 deficiency is a major cause of rhabdomyolysis that are precipitated by febrile illness. The prognosis is poor, with one-third of patients dying from cardiac arrest during a crisis episode. Apart from acute rhabdomyolysis, most patients are healthy, showing normal clinical and cardiac ultrasound parameters. PATIENTS AND METHODS: We report cardiac and exercise examinations of 8 children carrying two LPIN1 mutations. The examinations were performed outside of a myolysis episode, but one patient presented with fever during one examination...
March 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29315095/observational-study-in-healthy-volunteers-to-define-interobserver-reliability-of-ultrasound-haemodynamic-monitoring-techniques-performed-by-trainee-doctors
#20
Benjamin M Bussmann, Shrey Sharma, David Mcgregor, William Hulme, Tim Harris
OBJECTIVES: Bedside ultrasound is increasingly being used to guide fluid management in shocked patients. Little data exist on the inter-rater reliability of techniques used, especially when performed by nonexpert trainee doctors. The primary aim of this study is to measure the inter-rater reliability of five ultrasound techniques commonly used to guide fluid management: inferior vena cava collapsibility index (IVCCI), transthoracic echocardiography (TTE)-derived stroke volumes, ultrasound cardiac output monitor (USCOM) derived stroke volume and carotid artery blood flow and corrected flow time measurements...
January 8, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
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