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https://www.readbyqxmd.com/read/28342714/higher-uric-acid-serum-levels-are-associated-with-better-muscle-function-in-the-oldest-old-results-from-the-mugello-study
#1
R Molino-Lova, F Sofi, G Pasquini, F Vannetti, S Del Ry, C Vassalle, M Clerici, S Sorbi, C Macchi
BACKGROUND: Sarcopenia is the progressive loss of muscle mass and strength that occurs with advancing age and plays a pivotal role in the causal pathway leading to frailty, disability and, eventually, to death among older persons. As oxidative damage of muscle proteins has been shown to be a relevant contributory factor, in this study we hypothesized that uric acid (UA), a powerful endogenous antioxidant, might exert a protective effect on muscle function in the oldest old and we tested our hypothesis in a group of nonagenarians who participated in the Mugello Study...
March 22, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28340553/promoting-independence-health-and-well-being-for-older-people-a-feasibility-study-of-computer-aided-health-and-social-risk-appraisal-system-in-primary-care
#2
Kate Walters, Kalpa Kharicha, Claire Goodman, Melanie Handley, Jill Manthorpe, Mima Cattan, Steve Morris, Caroline S Clarke, Jeff Round, Steve Iliffe
BACKGROUND: With population ageing, research is needed into new low-cost, scalable methods of effective promotion of health and wellbeing for older people. We aimed to assess feasibility, reach and costs of implementing a new tailored computer-aided health and social risk appraisal system in primary care. METHODS: Design: Feasibility study. SETTING: Five General Practices in London (Ealing) and Hertfordshire, United Kingdom (UK) Participants: Random sample of patients aged 65 + years...
March 24, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28329171/body-mass-index-and-waist-circumference-as-predictors-of-disability-in-nonagenarians-the-vitality-90-study
#3
Inna Lisko, Kristina Tiainen, Jani Raitanen, Juulia Jylhävä, Mikko Hurme, Antti Hervonen, Marja Jylhä, Sari Stenholm
Background: Only scarce data exist on the association between obesity and disability in the oldest old. The purpose of this prospective study is to examine if body mass index and waist circumference (WC) are associated with incident mobility and activities of daily living (ADL) disability in nonagenarians. Methods: We used longitudinal data from the Vitality 90+ Study, which is a population-based study conducted at the area of Tampere, Finland. Altogether 291 women and 134 men, aged 90-91 years, had measured data on body mass index and/or WC and did not have self-reported mobility or ADL disability at baseline...
March 14, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28324124/osteoporosis-in-frail-patients-a-consensus-paper-of-the-belgian-bone-club
#4
REVIEW
E Gielen, P Bergmann, O Bruyère, E Cavalier, P Delanaye, S Goemaere, J-M Kaufman, M Locquet, J-Y Reginster, S Rozenberg, A-M Vandenbroucke, J-J Body
In this consensus paper, the Belgian Bone Club aims to provide a state of the art on the epidemiology, diagnosis, and management of osteoporosis in frail individuals, including patients with anorexia nervosa, patients on dialysis, cancer patients, persons with sarcopenia, and the oldest old. All these conditions may indeed induce bone loss that is superimposed on physiological bone loss and often remains under-recognized and under-treated. This is of particular concern because of the major burden of osteoporotic fractures in terms of morbidity, mortality, and economic cost...
March 21, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28323827/dementia-in-the-oldest-old-beyond-alzheimer-disease
#5
Aimee L Pierce, Claudia H Kawas
In a Perspective, Aimee Pierce and Claudia Kawas discuss risk factors and pathologies of dementia in the oldest-old.
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28322848/cd34-cell-count-predicts-long-lasting-life-in-the-oldest-old
#6
Giuseppe Mandraffino, Caterina Oriana Aragona, Giorgio Basile, Valentina Cairo, Federica Mamone, Carmela Morace, Angela D'Ascola, Angela Alibrandi, Alberto Lo Gullo, Saverio Loddo, Antonino Saitta, Egidio Imbalzano
Circulating progenitor cells (CPCs) represent a pool of cells capable of differentiating into mature cells of different organs and systems, promoting tissue maintenance and repair. Among CPCs, CD34+cells (CD34+CPCs) seem to predict outcome in CV disease, also in elderly people. A decline in CD34+CPCs was reported with advancing age. Moreover, aging is associated with a state of chronic inflammation, influencing life expectancy. Our purpose was to investigate a 10-year predictive ability of CD34+CPCs, inflammatory marker levels, classic CV risk factors (CVRFs), and Framingham Risk Score (FRS) in a population of healthy, self-sufficient octogenarians...
March 16, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28286214/cognitive-status-in-the-oldest-old-and-centenarians-a-condition-crucial-for-quality-of-life-methodologically-difficult-to-assess
#7
REVIEW
Beatrice Arosio, Rita Ostan, Daniela Mari, Sarah Damanti, Francesco Ronchetti, Sara Arcudi, Maria Scurti, Claudio Franceschi, Daniela Monti
Human life expectancy and the number of the oldest old are rapidly increasing worldwide. Advanced age is the main risk factor for dementia, representing one of the major causes of disability/dependency among older people with a strong impact on their families/caregivers. Centenarians have reached the extreme limits of human life escaping or delaying the major age-related diseases. Thus, these extraordinary individuals embody the best model to answer the crucial question if cognitive decline and dementia are progressive and unavoidable occurrences of increasing age...
March 9, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28285816/survival-disabilities-in-activities-of-daily-living-and-physical-and-cognitive-functioning-among-the-oldest-old-in-china-a-cohort-study
#8
Yi Zeng, Qiushi Feng, Therese Hesketh, Kaare Christensen, James W Vaupel
BACKGROUND: The oldest-old (those aged ≥80 years) are the most rapidly growing age group globally, and are most in need of health care and assistance. We aimed to assess changes in mortality, disability in activities of daily living, and physical and cognitive functioning among oldest-old individuals between 1998 and 2008. METHODS: We used data from the Chinese Longitudinal Healthy Longevity Study. Three pairs of cohorts aged 80-89 years, 90-99 years, and 100-105 years (in total, 19 528 oldest-old participants) were examined; the two cohorts in each pair were born 10 years apart, with the same age at the time of the assessment in the 1998 and 2008 surveys...
March 9, 2017: Lancet
https://www.readbyqxmd.com/read/28285815/china-s-oldest-old-prospects-for-good-health-in-late-life
#9
Olga Theou, Kenneth Rockwood
No abstract text is available yet for this article.
March 9, 2017: Lancet
https://www.readbyqxmd.com/read/28282728/profiles-in-emotional-aging-does-age-matter
#10
Igone Etxeberria, Itziar Etxebarria, Elena Urdaneta
OBJECTIVES: The aim of this research project was to define emotional profiles in elderly people and to analyze the presence of each one in different age groups (from 65 to 74, 75 to 84, 85 to 94 and 95 to 104). METHOD: The sample group comprised 257 elderly people not suffering from cognitive impairment who were independent in the Basic and Instrumental Activities of Daily Living. The following emotional variables were analyzed: positive and negative affect, life satisfaction, loneliness, and regulation strategies...
February 17, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28276619/hospital-admissions-by-the-oldest-old-past-trends-in-one-of-the-most-ageing-countries-in-the-world
#11
Daniela Brandão, Oscar Ribeiro, Alberto Freitas, Constança Paúl
AIM: To examine discharges of octogenarians, nonagenarians and centenarians from Portuguese public hospitals, namely admission type, principal diagnoses, comorbidities and length of stay. METHODS: The present study used administrative data from public acute care hospitals in the Portuguese National Health Service. All discharges of persons aged ≥80 years between 2000 and 2014 were analyzed. HCUP Clinical Classifications Software was considered to aggregate principal diagnosis, and comorbidities were assessed using the Charlson Comorbidity Index computed using International Classification of Diseases 9th Revision Clinical Modification codes...
March 9, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28275649/population-based-analysis-of-pathological-correlates-of-dementia-in-the-oldest-old
#12
Maarit Tanskanen, Mira Mäkelä, Irma-Leena Notkola, Liisa Myllykangas, Sari Rastas, Minna Oinas, Perttu J Lindsberg, Tuomo Polvikoski, Pentti J Tienari, Anders Paetau
OBJECTIVE: The aim of this study was to analyze brain pathologies which cause dementia in the oldest old population. METHODS: All 601 persons aged ≥85 years living in the city of Vantaa (Finland), on April 1st, 1991 formed the study population of the Vantaa85 +  study, 300 of whom were autopsied during follow-up (79.5% females, mean age-at-death 92 ± 3.7 years). Alzheimer's disease (AD) pathology (tau and beta-amyloid [Aβ]), cerebral amyloid angiopathy (CAA) and Lewy-related pathologies were analyzed...
March 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28244704/identification-of-dietary-patterns-and-their-relationships-with-general-and-oral-health-in-the-very-old
#13
Yusuke Osawa, Yasumichi Arai, Michiyo Takayama, Takumi Hirata, Midori Kawasaki, Yukiko Abe, Toshimitsu Iinuma, Satoshi Sasaki, Nobuyoshi Hirose
Little is known about the dietary patterns of Asian populations aged >=85 years and their associated factors. Thus, we aimed to (1) identify these dietary patterns and (2) clarify the relationships between the dietary pattern and health outcomes in a community-dwelling very old population. The Tokyo Oldest Old Survey on Total Health study is an observational cohort study comprising 512 Japanese subjects (women, n=288; men, n=224; age, 87.8±2.2 years). Dietary patterns were assessed by principal component analysis using a brief self-administered diet history questionnaire...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28244574/the-role-of-uric-acid-for-predicting-future-metabolic-syndrome-and-type-2-diabetes-in-older-people
#14
J-B Chang, Y-L Chen, Y-J Hung, C-H Hsieh, C-H Lee, D Pei, J-D Lin, C-Z Wu, Y-J Liang, C-M Lin
OBJECTIVE: Although it is known that high uric acid (UA) level is associated with type 2 diabetes (T2DM) and metabolic syndrome (MetS), most of the previous studies were focused on adults. Since aging becomes a major problem for many societies, in this longitudinal study, we investigated the role of UA in future T2DM and MetS in a large cohort of people who were older than 65 years. DESIGN: A cross-sectional and longitudinal study. SETTING/PARTICIPANTS: 18,907 elderly (9,732 men, 9,175 women) aged above 65 years, enrolled from health check-up centers, were classified into three subgroups by 10-year intervals (young old 65-74 years, YO; old old 75-84 years, OO; and oldest old 85-94 years, ODO), with the average follow-up period of 4...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28244570/factors-affecting-functional-impairment-among-elderly-germans-results-of-a-longitudinal-study
#15
A Hajek, T Luck, C Brettschneider, T Posselt, C Lange, B Wiese, S Steinmann, S Weyerer, J Werle, M Pentzek, A Fuchs, J Stein, H Bickel, E Mösch, M Wagner, K Heser, W Maier, J M Scherer, S G Riedel-Heller, H-H König
OBJECTIVE: To investigate causal factors of functional impairment in old age in a longitudinal approach. DESIGN: A population-based prospective cohort study. SETTING: Elderly individuals were recruited via GP offices at six study centers in Germany. They were observed every 1.5 years over six waves. PARTICIPANTS: Three thousand two hundred fifty-six people aged 75 years and older at baseline. MEASUREMENTS: Functional impairment was quantified by the Lawton and Brody Instrumental Activities of Daily Living scale (IADL) and the Barthel-Index (BI)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28244566/reversible-states-of-physical-and-or-cognitive-dysfunction-a-9-year-longitudinal-study
#16
C Qualls, D L Waters, B Vellas, D T Villareal, P J Garry, A Gallini, S Andrieu
OBJECTIVES: To determine 1) age-adjusted transition probabilities to worsening physical/cognitive function states, reversal to normal cognition/physical function, or maintenance of normal state; 2) whether these transitions are modulated by sex, BMI, education, hypertension (HTN), health status, or APOE4; 3) whether worsening gait speed preceded cognition change, or vice versa. DESIGN: Analysis of 9-year prospective cohort data from the New Mexico Aging Process Study...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28236610/zopiclone-use-and-risk-of-fractures-in-older-people-population-based-study
#17
Prasad S Nishtala, Te-Yuan Chyou
OBJECTIVES: The primary objective was to evaluate the risk of fractures associated with use of zopiclone, a new Z-hypnotic, in a population-based cohort of older people in New Zealand (NZ) in a real-world setting. The secondary objective was to examine a nonlinear relationship with age and risk for fractures in zopiclone users. DESIGN: Population-based cohort study with a case-crossover design. SETTING: A nationwide representative sample of New Zealanders aged 65 years and older sourced from the pharmaceutical collections and hospital discharges...
April 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28212616/general-practitioners-views-on-long-term-prescription-and-use-of-problematic-and-potentially-inappropriate-medication-for-oldest-old-patients-a-qualitative-interview-study-with-gps-cim-triad-study
#18
Nadine Janis Pohontsch, Kathrin Heser, Antje Löffler, Britta Haenisch, Debora Parker, Tobias Luck, Steffi G Riedel-Heller, Wolfgang Maier, Frank Jessen, Martin Scherer
BACKGROUND: Potentially inappropriate medication (PIM) is defined as medication with uncertain therapeutic effects and/or potential adverse drug reactions outweighing the clinical benefits. The prescription rate of PIM for oldest-old patients is high despite the existence of lists of PIM (e.g. the PRISCUS list) and efforts to raise awareness. This study aims at identifying general practitioners' views on PIM and aspects affecting the (long-term) use of PIM. METHODS: As part of the CIM-TRIAD study, we conducted semi-structured, qualitative interviews with 47 general practitioners, discussing 25 patients with and 22 without PIM (according to the PRISCUS list)...
February 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28206976/lipid-and-alzheimer-s-disease-genes-associated-with-healthy-aging-and-longevity-in-healthy-oldest-old
#19
Lauren C Tindale, Stephen Leach, John J Spinelli, Angela R Brooks-Wilson
Several studies have found that long-lived individuals do not appear to carry lower numbers of common disease-associated variants than ordinary people; it has been hypothesized that they may instead carry protective variants. An intriguing type of protective variant is buffering variants that protect against variants that have deleterious effects. We genotyped 18 variants in 15 genes related to longevity or healthy aging that had been previously reported as having a gene-gene interaction or buffering effect...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28198066/breathing-not-properly-in-the-oldest-old-is-brain-natriuretic-peptide-a-poor-test-for-the-diagnosis-of-heart-failure-in-the-elderly
#20
EDITORIAL
Michele Emdin, Alberto Aimo, Claudio Passino, Giuseppe Vergaro
No abstract text is available yet for this article.
February 15, 2017: European Journal of Heart Failure
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