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https://www.readbyqxmd.com/read/29444506/the-impact-of-advanced-age-on-driving-safety-in-adults-with-medical-conditions
#1
Sanghee Moon, Maud Ranchet, Abiodun Emmanuel Akinwuntan, Mark Tant, David Brian Carr, Mukaila Ajiboye Raji, Hannes Devos
BACKGROUND: Adults aged 85 and older, often referred to as the oldest-old, are the fastest-growing segment of the population. The rapidly increasing number of older adults with chronic and multiple medical conditions poses challenges regarding their driving safety. OBJECTIVE: To investigate the effect of advanced age on driving safety in drivers with medical conditions. METHODS: We categorized 3,425 drivers with preexisting medical conditions into four age groups: middle-aged (55-64 years, n = 1,386), young-old (65-74 years, n = 1,013), old-old (75-84 years, n = 803), or oldest-old (85 years and older, n = 223)...
February 14, 2018: Gerontology
https://www.readbyqxmd.com/read/29411449/caide-dementia-risk-score-alzheimer-and-cerebrovascular-pathology-a-population-based-autopsy-study
#2
Babak Hooshmand, Tuomo Polvikoski, Miia Kivipelto, Maarit Tanskanen, Liisa Myllykangas, Mira Mäkelä, Minna Oinas, Anders Paetau, Alina Solomon
BACKGROUND: CAIDE Dementia Risk Score is a tool for estimating dementia risk in the general population. Its longitudinal associations with Alzheimer or vascular neuropathology in the oldest old are not known. AIM: To explore the relationship between CAIDE Dementia Risk Score at baseline and neuritic plaques, neurofibrillary tangles, cerebral infarcts, and cerebral amyloid angiopathy (CAA) after up to 10 years follow-up in the Vantaa 85+ population. METHODS: Study population included 149 participants aged ≥85 years, without dementia at baseline, and with available clinical and autopsy data...
January 25, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29408957/disability-prior-to-death-among-the-oldest-old-in-china
#3
Zuyun Liu, Ling Han, Xiaofeng Wang, Qiushi Feng, Thomas M Gill
Background: To estimate the prevalence of disability during the last three years prior to death among the oldest-old (≥80 years) in China. Methods: We used data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a nationally representative study of the oldest-old in China. The analytic sample included 23,934 decedents who died between 1998 and 2014 and had at least one interview within the last three years of life. Disability was defined as being incontinent or needing assistance in performing one or more of five other essential activities (bathing, transferring, dressing, eating, and toileting)...
February 2, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29405230/trajectory-of-the-mapt-pacc-preclinical-alzheimer-cognitive-composite-in-the-placebo-group-of-a-randomized-control-trial-results-from-the-mapt-study-lessons-for-further-trials
#4
J K Chhetri, P de Souto Barreto, C Cantet, M Cesari, N Coley, S Andrieu, B Vellas
Defining the primary cognitive endpoint is a major decision for Alzheimer's disease preventive trials. As an example for further trials we present in detail the three-year cognitive decline in the placebo group of MAPT trial, a randomized controlled trial (RCT) using a cognitive composite score (MAPT-PACC). Participants were dementia-free adults 70 years or older, with subjective memory complaints. Our findings as expected showed subjects with older age (>75), higher beta amyloid brain deposition, APOE-ε4 allele carriers, with low RBC DHA+EPA levels and higher CDR level are at higher risk of cognitive decline...
2018: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29397885/relation-of-age-and-health-related-quality-of-life-to-invasive-versus-ischemia-guided-management-of-patients-with-non-st-elevation-myocardial-infarction
#5
Krishna K Patel, Suzanne V Arnold, Philip G Jones, Mohammed Qintar, Karen P Alexander, John A Spertus
In older patients with non-ST-elevation myocardial infarction, an initial invasive strategy reduces cardiovascular events compared with an ischemia-guided approach; however its association with health status outcomes is unknown. Among patients with non-ST-elevation myocardial infarction from 2 multicenter US acute myocardial infarction (AMI) registries, health status was assessed at baseline and at 1, 6, and 12 months after AMI using the Seattle Angina Questionnaire (SAQ) and the 12-item Short-Form Health Survey (SF-12)...
January 10, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29380854/association-between-body-mass-index-and-all-cause-mortality-among-oldest-old-chinese
#6
J Wang, A W Taylor, T Zhang, S Appleton, Z Shi
OBJECTIVES: To examine the association between BMI and all-cause mortality in the oldest old (≥80 years). DESIGN: The study used a prospective cohort study design. SETTING: Chinese Longitudinal Healthy Longevity Survey (CLHLS) between 1998/99 and 2011. POPULATION: 8026 participants aged 80 years and older were followed every two to three years. MEASUREMENTS: Body weight and knee height were measured...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29366388/burden-of-cardiovascular-disease-across-29-countries-and-gps-decision-to-treat-hypertension-in-oldest-old
#7
Sven Streit, Jacobijn Gussekloo, Robert A Burman, Claire Collins, Biljana Gerasimovska Kitanovska, Sandra Gintere, Raquel Gómez Bravo, Kathryn Hoffmann, Claudia Iftode, Kasper L Johansen, Ngaire Kerse, Tuomas H Koskela, Sanda Kreitmayer Peštić, Donata Kurpas, Christian D Mallen, Hubert Maisonneuve, Christoph Merlo, Yolanda Mueller, Christiane Muth, Rafael H Ornelas, Marija Petek Šter, Ferdinando Petrazzuoli, Thomas Rosemann, Martin Sattler, Zuzana Švadlenková, Athina Tatsioni, Hans Thulesius, Victoria Tkachenko, Peter Torzsa, Rosy Tsopra, Canan Tuz, Marjolein Verschoor, Rita P A Viegas, Shlomo Vinker, Margot W M de Waal, Andreas Zeller, Nicolas Rodondi, Rosalinde K E Poortvliet
OBJECTIVES: We previously found large variations in general practitioner (GP) hypertension treatment probability in oldest-old (>80 years) between countries. We wanted to explore whether differences in country-specific cardiovascular disease (CVD) burden and life expectancy could explain the differences. DESIGN: This is a survey study using case-vignettes of oldest-old patients with different comorbidities and blood pressure levels. An ecological multilevel model analysis was performed...
January 25, 2018: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/29364788/sharing-is-caring-the-potential-of-the-sharing-economy-to-support-aging-in-place
#8
Julie Miller, Carley Ward, Chaiwoo Lee, Lisa D'Ambrosio, Joseph Coughlin
This article explores innovative applications of sharing economy services that have the potential to support a population aging in place, especially the "oldest old," aged 85 and older, and their caregivers. A mixed-methods study conducted by the MIT AgeLab examined perceptions of and experiences with sharing economy services, ultimately finding opportunities and barriers to use. Thus, although sharing economy services have potential to support aging in place, to do so successfully will require reconstructing how older adults, family caregivers, aging service professionals, gerontology educators, and gerontology students conceptualize and deliver care to an aging population...
January 24, 2018: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/29351872/low-cortical-iron-and-high-entorhinal-cortex-volume-promote-cognitive-functioning-in-the-oldest-old
#9
Jiri M G van Bergen, Xu Li, Frances C Quevenco, Anton F Gietl, Valerie Treyer, Sandra E Leh, Rafael Meyer, Alfred Buck, Philipp A Kaufmann, Roger M Nitsch, Peter C M van Zijl, Christoph Hock, Paul G Unschuld
The aging brain is characterized by an increased presence of neurodegenerative and vascular pathologies. However, there is substantial variation regarding the relationship between an individual's pathological burden and resulting cognitive impairment. To identify correlates of preserved cognitive functioning at highest age, the relationship between β-amyloid plaque load, presence of small vessel cerebrovascular disease (SVCD), iron-burden, and brain atrophy was investigated. Eighty cognitively unimpaired participants (44 oldest-old, aged 85-96 years; 36 younger-old, aged 55-80 years) were scanned by integrated positron emission tomography-magnetic resonance imaging for assessing beta regional amyloid plaque load (18F-flutemetamol), white matter hyperintensities as an indicator of SVCD (fluid-attenuated inversion recovery-magnetic resonance imaging), and iron load (quantitative susceptibility mapping)...
December 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29349247/incorporating-biomarkers-into-the-study-of-socio-economic-status-and-health-among-older-adults-in-china
#10
Melanie Sereny Brasher, Linda K George, Xiaoming Shi, Zhaoxue Yin, Yi Zeng
The social gradient in health - that individuals with lower SES have worse health than those with higher SES- is welldocumented using self-reports of health in more developed countries. Less is known about the relationship between SES and health biomarkers among older adults residing in less developed countries. We use data from the ChineseLongitudinal Healthy Longevity Survey (CLHLS) longevity areas sub-sample to examine the social gradient in healthamong rural young-old and oldest-old adults (N=2,121). Our health indicators include individual biomarkers, metabolic syndrome, and self-reports of health...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29319499/similar-treatment-outcomes-with-ginkgo-biloba-extract-egb-761-and-donepezil-in-alzheimer-s-dementia-in-very-old-age-a-retrospective-observational-study
#11
Michael Rapp, Martin Burkart, Thomas Kohlmann, Jens Bohlken
OBJECTIVE: To provide pilot data for the safety and efficacy of EGb 761 in the oldest-old patients (aged 80 or older). MATERIALS AND METHODS: In a retrospective analysis, we compared treatment outcomes with EGb 761 or donepezil over 12 months in 189 patients aged 80 years or older suffering from Alzheimer's disease (AD). RESULTS: Over 12 months, there was no significant difference in cognitive decline, measured with the mini-mental state examination (MMSE) score, between donepezil and EGb 761 (p = 0...
January 10, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29318089/falls-cognitive-function-and-balance-profiles-of-singapore-community-dwelling-elderly-individuals-key-risk-factors
#12
Mei Teng Woo, Keith Davids, Jarmo Liukkonen, Jia Yi Chow, Timo Jaakkola
Objective: This study compared occurrence of falls, cognitive function, and balance profiles across participants in elderly age categories, investigating associations between the 3 aspects in a sample of Singapore's elderly population. Method: Community-dwelling elderly individuals (N = 385) were randomly recruited and grouped into "young-old (65-74 years)," "medium-old (75-84 years)," and "oldest-old (above 85 years)" groups. The Fallproof Health and Activity questionnaire, adapted Mini-Mental State Examination (MMSE), and Berg Balance Scale (BBS) tests were used to survey information related to falls, cognition, and balance profiles...
December 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29317078/the-protected-survivor-model-using-resistant-successful-cognitive-aging-to-identify-protection-in-the-very-old
#13
Jeremy M Silverman, James Schmeidler
For some cardiovascular risk factors, association with risk for cognitive impairment observed in early old age is reduced, or paradoxically even reversed, as age of outcome increases. Successful cognitive aging is intact cognition in the oldest-old; we define resistant successful cognitive aging as successful cognitive aging despite high risk. The protected survivor model posits that a minority of the general population has a protective factor that mitigates the negative effect of a risk factor on successful cognitive aging for the unprotected majority...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29313171/gender-effect-on-well-being-of-the-oldest-old-a-survey-of-nonagenarians-living-in-tuscany-the-mugello-study
#14
Luca Padua, Patrizio Pasqualetti, Daniele Coraci, Isabella Imbimbo, Alessandro Giordani, Claudia Loreti, Camillo Marra, Raffaello Molino-Lova, Guido Pasquini, Ilaria Simonelli, Federica Vannetti, Claudio Macchi
The population of industrialized nations is progressively aging, with Italy having one of the most elderly populations in the world. Natural aging may be associated with physical and cognitive impairments, often straining public resources. The present study aims to investigate the influence of gender on wellness of the nonagenarians. We evaluated quality of life among nonagenarians living in the Mugello area, an Italian location with a large population of individuals > 90 years, using the Health Survey Scoring SF-12...
January 8, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29288647/assessing-the-different-oncologic-disease-distribution-and-postoperative-complications-of-octogenarian-and-nonagenarian-head-and-neck-oncology%C3%A2-patients
#15
Doron Sagiv, Sahar Nadel, Yoav Pinhas Talmi, Ran Yahalom, Michael Wolf, Eran Emanuel Alon
PURPOSE: The admission rate of patients aged 80 years or older (oldest-old) with head and neck (HN) oncologic disease is on the rise. Our goal was to study the demographic characteristics, reasons for admission, types of surgical procedures, and postoperative complications of the oldest-old patients with HN malignancy. MATERIALS AND METHODS: We conducted a retrospective cohort study including all inpatients aged 80 years or older who were admitted to the department of otolaryngology-head and neck surgery or department of oral and maxillofacial surgery because of HN oncologic disease between 2009 and 2013...
December 7, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29258480/end-of-life-care-preferences-among-people-of-advanced-age-lilacs-nz
#16
Merryn Gott, Rosemary Frey, Janine Wiles, Anna Rolleston, Ruth Teh, Tess Moeke-Maxwell, Ngaire Kerse
BACKGROUND: Understanding end of life preferences amongst the oldest old is crucial to informing appropriate palliative and end of life care internationally. However, little has been reported in the academic literature about the end of life preferences of people in advanced age, particularly the preferences of indigenous older people, including New Zealand Māori. METHODS: Data on end of life preferences were gathered from 147 Māori (aged >80 years) and 291 non- Māori aged (>85 years), during three waves of Te Puawaitangi O Nga Tapuwae Kia Ora Tonu, Life and Living in Advanced Age (LiLACs NZ)...
December 19, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29249210/management-and-outcomes-in-the-oldest-old-population-with-glioblastoma
#17
Fabio Y Moraes, Andrea Lo, Erin R Morgan, Barbara-Ann Millar, David B Shultz, Catherine Maurice, Craig Harlos, Paul Kongkham, Mark Bernstein, Gelareh Zadeh, Normand Laperriere, Warren Mason, Alejandro Berlin
OBJECTIVES: Glioblastoma is a lethal disease in the elderly population. We aimed to evaluate disease and treatment outcomes in the oldest-old patients. METHODS: Patients >80 years old with histologically confirmed glioblastoma treated between 2004 and 2009 were identified. We included patients managed with best supportive care (BSC), temozolomide (TMZ) alone, radiotherapy (RT) alone, or concomitantly with TMZ (CRT). Survival outcomes were analyzed using the Kaplan-Meier method...
December 18, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29247517/left-atrial-function-and-mortality-in-the-oldest-old
#18
David Leibowitz, Jonathan Koslowsky, Dan Gilon, Jeremy M Jacobs, Irit Stessman-Lande, Jochanan Stessman
BACKGROUND: Previous studies demonstrated that left atrium (LA) size is associated with mortality in an elderly population. It remains unclear whether indices of LA function including reservoir, conduit, or booster elements of LA function provide incremental prognostic information. HYPOTHESIS: Echocardiographic measures of the various parameters of LA function would predict 5-year mortality in a community-dwelling population of 85 to 86 year olds independently of LA volume...
December 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29244847/cognitive-failures-in-late-adulthood-the-role-of-age-social-context-and-depressive-symptoms
#19
Paul Kenneth Hitchcott, Maria Chiara Fastame, Dalila Langiu, Maria Pietronilla Penna
The incidence of self-reported cognitive failures among older adults may be an index of successful cognitive aging. However, self-reported cognitive failures are biased by variation in depressive symptomatology. This study examined age-related and socio-cultural context effects on cognitive failures while controlling for depressive symptoms. Both overall and specific factors of cognitive failures were determined. A further goal was to investigate the relationship between working memory and cognitive efficiency measures and cognitive failures...
2017: PloS One
https://www.readbyqxmd.com/read/29244058/antidepressant-use-and-cognitive-outcomes-in-very-old-women
#20
Yue Leng, Susan J Diem, Katie L Stone, Kristine Yaffe
Background: Antidepressant use is very common in the elderly, but the effects of antidepressants on cognition in the elderly are controversial with some studies suggesting harm and others protection. We aimed to investigate the association between different antidepressant use and change in cognition and risk of mild cognitive impairment (MCI) or dementia in very old women. Methods: We examined 1,234 community-dwelling women (mean age 83.2 years) from the Study of Osteoporotic Fractures...
December 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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