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https://www.readbyqxmd.com/read/28436390/biomarkers-for-early-diagnosis-of%C3%A2-alzheimer-s-disease-in-the-oldest-old-yes-or-no
#1
Lucia Paolacci, David Giannandrea, Patrizia Mecocci, Lucilla Parnetti
In recent years, many efforts have been spent to identify sensitive biomarkers able to improve the accuracy of Alzheimer's disease (AD) diagnosis. Two different workgroups (NIA-AA and IWG) included cerebrospinal fluid (CSF) and neuroimaging findings in their sets of criteria in order to improve diagnostic accuracy as well as early diagnosis. The number of subjects with cognitive impairment increases with aging but the oldest old (≥85 years of age), the fastest growing age group, is still the most unknown from a biological point of view...
April 15, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28436187/slow-gait-speed-as-a-predictor-of-1-year-cognitive-decline-in-a-veterans-retirement-community-in-southern-taiwan
#2
Chiao-Lin Hsu, Chih-Kuang Liang, Mei-Chen Liao, Ming-Yueh Chou, Yu-Te Lin
AIM: Slow gait speed has been associated with mortality, poor physical function and disability in older people. Our aim was to evaluate the association between slow gait speed and rapid cognitive decline among oldest-old men in Taiwan. METHODS: We carried out a longitudinal cohort study in a veterans' retirement community, and enrolled 249 male residents aged 80 years and older. Slow gait speed was defined as <1 m/s, and rapid cognitive decline was defined as a Mini-Mental State Examination (MMSE) decline of ≥3 points over 1 year...
April 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28431552/strategies-to-improve-engagement-of-hard-to-reach-older-people-in-research-on-health-promotion-a-systematic-review
#3
Ann E M Liljas, Kate Walters, Ana Jovicic, Steve Iliffe, Jill Manthorpe, Claire Goodman, Kalpa Kharicha
BACKGROUND: This systematic review aimed to identify facilitators, barriers and strategies for engaging 'hard to reach' older people in research on health promotion; the oldest old (≥80 years), older people from black and minority ethnic groups (BME) and older people living in deprived areas. METHODS: Eight databases were searched to identify eligible studies using quantitative, qualitative, and mixed research methods. Using elements of narrative synthesis, engagement strategies, and reported facilitators and barriers were identified, tabulated and analysed thematically for each of the three groups of older people...
April 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28427345/variation-in-gp-decisions-on-antihypertensive-treatment-in-oldest-old-and-frail-individuals-across-29-countries
#4
Sven Streit, Marjolein Verschoor, Nicolas Rodondi, Daiana Bonfim, Robert A Burman, Claire Collins, Gerasimovska Kitanovska Biljana, Sandra Gintere, Raquel Gómez Bravo, Kathryn Hoffmann, Claudia Iftode, Kasper L Johansen, Ngaire Kerse, Tuomas H Koskela, Sanda Kreitmayer Peštić, Donata Kurpas, Christian D Mallen, Hubert Maisoneuve, Christoph Merlo, Yolanda Mueller, Christiane Muth, Marija Petek Šter, Ferdinando Petrazzuoli, Thomas Rosemann, Martin Sattler, Zuzana Švadlenková, Athina Tatsioni, Hans Thulesius, Victoria Tkachenko, Peter Torzsa, Rosy Tsopra, Tuz Canan, Rita P A Viegas, Shlomo Vinker, Margot W M de Waal, Andreas Zeller, Jacobijn Gussekloo, Rosalinde K E Poortvliet
BACKGROUND: In oldest-old patients (>80), few trials showed efficacy of treating hypertension and they included mostly the healthiest elderly. The resulting lack of knowledge has led to inconsistent guidelines, mainly based on systolic blood pressure (SBP), cardiovascular disease (CVD) but not on frailty despite the high prevalence in oldest-old. This may lead to variation how General Practitioners (GPs) treat hypertension. Our aim was to investigate treatment variation of GPs in oldest-olds across countries and to identify the role of frailty in that decision...
April 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28427051/subjective-time-perceptions-and-aging-well-a-review-of-concepts-and-empirical-research-a-mini-review
#5
Martina Gabrian, Anne J Dutt, Hans-Werner Wahl
Human beings impose subjective, time-related interpretations on their existence, and the experience of time is a major aspect of lifespan development. In this mini-review, we understand subjective time as the way individuals subjectively perceive and evaluate the passing of their personal "objective" lifetime. A broad range of constructs and operationalizations has been developed in (gero-) psychology to capture subjective time, including future time perspective, personal goals, or autobiographical memories...
April 21, 2017: Gerontology
https://www.readbyqxmd.com/read/28410660/late-onset-alzheimer-disease
#6
REVIEW
Aimee L Pierce, Szofia S Bullain, Claudia H Kawas
The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease...
May 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28407800/advance-directives-and-power-of-attorney-for-health-care-in-the-oldest-old-results-of-the-agequalide-study
#7
Tobias Luck, Francisca S Rodriguez, Birgitt Wiese, Carolin van der Leeden, Kathrin Heser, Horst Bickel, Jürgen In der Schmitten, Hans-Helmut Koenig, Siegfried Weyerer, Silke Mamone, Tina Mallon, Michael Wagner, Dagmar Weeg, Angela Fuchs, Christian Brettschneider, Jochen Werle, Martin Scherer, Wolfgang Maier, Steffi G Riedel-Heller
BACKGROUND: Completion of advance directives (ADs) and power of attorney (POA) documents may protect a person's autonomy in future health care situations when the individual lacks decisional capacity. As such situations become naturally much more common in old age, we specifically aimed at providing information on (i) the frequency of ADs/POA in oldest-old individuals and (ii) factors associated with having completed ADs/POA. METHODS: We analyzed data of oldest-old primary care patients (85+ years; including community-dwelling and institutionalized individuals) within the German AgeQualiDe study...
April 13, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28391702/aging-with-purpose
#8
Justine Irving, Sandra Davis, Aileen Collier
Purpose can provide a sense of intentionality, guide behavior to achieve personal aims and living objectives, and may offer insight into how and why certain people remain healthy over time. A review of the literature sought to identify contemporary research pertaining to purpose and older adults. Thirty-one studies were selected for evaluation based on inclusion criteria. Research outcomes suggest that greater reported purpose is related to a range of better health and well-being outcomes for older adults. With few exceptions, the literature demonstrates that purpose declines with age...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28389834/chronic-subdural-hematoma-in-the-oldest-old-population
#9
REVIEW
Miguel Gelabert-González, Paula Román-Pena, Eduardo Arán-Echabe
No abstract text is available yet for this article.
April 7, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28386536/the-otago-exercise-program-innovative-delivery-models-to-maximize-sustained-outcomes-for-high-risk-homebound-older-adults
#10
Tiffany E Shubert, Lavinia Spring Goto, Matthew Lee Smith, Luohua Jiang, Holly Rudman, Marcia G Ory
BACKGROUND: It is estimated one in two adults age 80 and over fall each year, resulting in substantial morbidity and mortality rates among this oldest-old population. The Otago Exercise program (OEP) is an evidence-based fall prevention program shown to reduce falls by 35% among high-risk older adults. The OEP was designed to be delivered in the home by physical therapists. This model has encountered multiple implementation challenges in the United States health-care system, which has resulted in the development and testing of innovative models to support a broader reach and dissemination of this program...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28385481/rehabilitation-services-use-and-patient-reported-outcomes-among-older-adults-in-the-united-states
#11
Nancy M Gell, Tracy M Mroz, Kushang V Patel
OBJECTIVES: To characterize rehabilitation service use among community-dwelling older adults in the United States by identifying predictors of rehabilitation utilization, patient-reported functional improvement and rehabilitation goal attainment. DESIGN: Cross-sectional analysis of the 2015 National Health and Aging Trends Study, which used an age-stratified, multistage sampling design and oversampled non-Hispanic Blacks and the oldest old (≥85 years). SETTING: Standardized, in-person home interviews and physical performance testing...
April 3, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28381194/prevalence-of-loneliness-over-ten-years-among-the-oldest-old
#12
Fredrica Nyqvist, Mima Cattan, Mia Conradsson, Marina Näsman, Yngve Gustafsson
AIMS: This study examined the prevalence of loneliness among the oldest old within a 10-year period and studied the influence of various sociodemographic, social and health characteristics on loneliness. METHODS: The study used population-based data from the Umeå85+/GErontological Regional DAtabase-study (GERDA) for the years 2000-2002, 2005-2007 and 2010-2012 including 85-year-old, 90-year-old and ⩾95-year-old participants. A final sample of 304 participants in 2000-2002, 329 participants in 2005-2007 and 401 participants in 2010-2012 was included in the analyses...
April 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28378616/effect-of-life-events-social-supports-and-personality-on-mental-status-in-later-life
#13
Kyuho Lee, Marissa Holst, Peter Martin, Leonard W Poon
The goal of this study was to explore the influences of proximal and distal life events on mental status in later life. Additionally, life events were categorized into positive and negative experiences. Data from 208 older adults over 80 years of age from the Georgia Centenarian Study were included in this study. Results from a series of blockwise regression analyses indicated that the number of distal negative life events that older adults had experienced was a predictor of older adults' better mental status...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28369563/underestimated-health-inequalities-among-older-people-a-consequence-of-excluding-the-most-disabled-and-disadvantaged
#14
Susanne Kelfve
Objectives: The present study analyzed whether estimates of health inequalities in old age are sensitive to the exclusion of people living in institutions and nonuse of proxy interviews. Method: Pooled data from the 2004 wave (n = 1,180, aged 69-100, primarily interviewed over the phone) and the 2011 wave (n = 931, aged 76-101, primarily interviewed face-to-face) of the Swedish Panel Study of Living Conditions of the Oldest Old were used to compare absolute and relative differences in disability and mortality between people with compulsory education and people with more than compulsory education...
March 29, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28369185/lower-likelihood-of-falling-at-age-90-is-associated-with-daily-exercise-a-quarter-of-a-century-earlier-the-90-study
#15
Annlia Paganini-Hill, Dana E Greenia, Shawna Perry, Seyed Ahmad Sajjadi, Claudia H Kawas, Maria M Corrada
Objective: to explore the relationship between risk of falling at age 90+ and prior physical activity at age 60-70s. Design: population-based cohort study (The 90+ Study). Setting: California retirement community. Participants: of 1596 cohort members, 1536 had both falls and prior activity data. Mean age = 94 years; 78% female; 99% Caucasian. Methods: time spent in active physical activity was self-reported in 1980s; medical history, medication, assistive devices, residence type, and falls (outcome) was collected in 2000s...
March 21, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28364542/defining-aging-phenotypes-and-related-outcomes-clues-to-recognize-frailty-in-hospitalized-older-patients
#16
Maura Marcucci, Carlotta Franchi, Alessandro Nobili, Pier Mannuccio Mannucci, Ilaria Ardoino
Background: Because frailty is a complex phenomenon associated with poor outcomes, the identification of patient profiles with different care needs might be of greater practical help than to look for a unifying definition. This study aimed at identifying aging phenotypes and their related outcomes in order to recognize frailty in hospitalized older patients. Methods: Patients aged 65 or older enrolled in internal medicine and geriatric wards participating in the REPOSI registry...
March 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28355325/estrogen-receptor-alpha-gene-xbai-a-g-polymorphism-influences-short-term-cognitive-decline-in-healthy-oldest-old-individuals
#17
Amanda Caroline Silva Chaves, Vanessa Gomes Fraga, Henrique Cerqueira Guimarães, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Maria das Graças Carvalho, Ana Paula Lucas Mota, Ieda de Fátima Oliveira Silva, Paulo Caramelli, Karina Braga Gomes, Patrícia Nessralla Alpoim
Methods: The individuals were categorized in two groups according to the presence or absence of cognitive decline. Cognitive data were related to genetic information. Results: The XbaI -351 AA genotype was more common among cognitive decliners, while -351G allele carriers showed cognitive stability or improvement. Conclusion: These results suggest that ESR-1 could be associated with one-year cognitive decline in healthy oldest-old individuals, since the estrogen pathway may be involved with neuroprotection, even in healthy brain aging...
March 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28349594/perceived-swallowing-problems-and-mortality-risk-in-very-elderly-people-%C3%A2-85%C3%A2-years-old-results-of-the-tokyo-oldest-old-survey-on-total-health-study
#18
Toshimitsu Iinuma, Takumi Hirata, Yasumichi Arai, Michiyo Takayama, Yukiko Abe, Motoko Fukumoto, Yusuke Fukui, Nobuhito Gionhaku
OBJECTIVE: The aim of this study was to clarify whether perceived swallowing problems affect the life expectancy of very elderly individuals. BACKGROUND: In an ageing society, oral function affects health status. In particular, a decline in swallowing function may increase the risk of various diseases, morbidity and malnutrition. MATERIALS AND METHODS: We evaluated 526 elderly individuals aged ≥85 years. All participants completed a questionnaire and underwent oral, physical and mental health examinations...
March 28, 2017: Gerodontology
https://www.readbyqxmd.com/read/28342714/higher-uric-acid-serum-levels-are-associated-with-better-muscle-function-in-the-oldest-old-results-from-the-mugello-study
#19
R Molino-Lova, F Sofi, G Pasquini, F Vannetti, S Del Ry, C Vassalle, M Clerici, S Sorbi, C Macchi
BACKGROUND: Sarcopenia is the progressive loss of muscle mass and strength that occurs with advancing age and plays a pivotal role in the causal pathway leading to frailty, disability and, eventually, to death among older persons. As oxidative damage of muscle proteins has been shown to be a relevant contributory factor, in this study we hypothesized that uric acid (UA), a powerful endogenous antioxidant, might exert a protective effect on muscle function in the oldest old and we tested our hypothesis in a group of nonagenarians who participated in the Mugello Study...
March 22, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28340553/promoting-independence-health-and-well-being-for-older-people-a-feasibility-study-of-computer-aided-health-and-social-risk-appraisal-system-in-primary-care
#20
Kate Walters, Kalpa Kharicha, Claire Goodman, Melanie Handley, Jill Manthorpe, Mima Cattan, Steve Morris, Caroline S Clarke, Jeff Round, Steve Iliffe
BACKGROUND: With population ageing, research is needed into new low-cost, scalable methods of effective promotion of health and wellbeing for older people. We aimed to assess feasibility, reach and costs of implementing a new tailored computer-aided health and social risk appraisal system in primary care. METHODS: Design: Feasibility study. SETTING: Five General Practices in London (Ealing) and Hertfordshire, United Kingdom (UK) Participants: Random sample of patients aged 65 + years...
March 24, 2017: BMC Family Practice
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