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https://www.readbyqxmd.com/read/28212616/general-practitioners-views-on-long-term-prescription-and-use-of-problematic-and-potentially-inappropriate-medication-for-oldest-old-patients-a-qualitative-interview-study-with-gps-cim-triad-study
#1
Nadine Janis Pohontsch, Kathrin Heser, Antje Löffler, Britta Haenisch, Debora Parker, Tobias Luck, Steffi G Riedel-Heller, Wolfgang Maier, Frank Jessen, Martin Scherer
BACKGROUND: Potentially inappropriate medication (PIM) is defined as medication with uncertain therapeutic effects and/or potential adverse drug reactions outweighing the clinical benefits. The prescription rate of PIM for oldest-old patients is high despite the existence of lists of PIM (e.g. the PRISCUS list) and efforts to raise awareness. This study aims at identifying general practitioners' views on PIM and aspects affecting the (long-term) use of PIM. METHODS: As part of the CIM-TRIAD study, we conducted semi-structured, qualitative interviews with 47 general practitioners, discussing 25 patients with and 22 without PIM (according to the PRISCUS list)...
February 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28206976/lipid-and-alzheimer-s-disease-genes-associated-with-healthy-aging-and-longevity-in-healthy-oldest-old
#2
Lauren C Tindale, Stephen Leach, John J Spinelli, Angela R Brooks-Wilson
Several studies have found that long-lived individuals do not appear to carry lower numbers of common disease-associated variants than ordinary people; it has been hypothesized that they may instead carry protective variants. An intriguing type of protective variant is buffering variants that protect against variants that have deleterious effects. We genotyped 18 variants in 15 genes related to longevity or healthy aging that had been previously reported as having a gene-gene interaction or buffering effect...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28198066/breathing-not-properly-in-the-oldest-old-is-brain-natriuretic-peptide-a-poor-test-for-the-diagnosis-of-heart-failure-in-the-elderly
#3
EDITORIAL
Michele Emdin, Alberto Aimo, Claudio Passino, Giuseppe Vergaro
No abstract text is available yet for this article.
February 15, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28187153/what-matters-for-life-satisfaction-among-the-oldest-old-evidence-from-china
#4
Sor Tho Ng, Nai Peng Tey, M Niaz Asadullah
OBJECTIVE: The world population is aging rapidly and the well-being of older people is of great interest. Therefore, this study investigates the determinants of life satisfaction among the oldest-old (i.e. individuals aged 80 or over) in China. MATERIALS AND METHODS: We use the 2011/2012 Chinese Longitudinal Healthy Longevity Survey data (n = 6530) for this paper. Logistic regression is used to analyse the effects of socio-demographic, economic, health, instrumental activities of daily living, family and community factors on life satisfaction and depression among the oldest-old in China...
2017: PloS One
https://www.readbyqxmd.com/read/28184889/dietary-habits-and-cognitive-impairment-risk-among-oldest-old-chinese
#5
Ruopeng An, Gordon Liu, Naiman Khan, Hai Yan, Youfa Wang
No abstract text is available yet for this article.
February 10, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28179606/carotid-plaque-score-and-risk-of-cardiovascular-mortality-in-the-oldest-old-results-from-the-tooth-study
#6
Takumi Hirata, Yasumichi Arai, Michiyo Takayama, Yukiko Abe, Kiyoshi Ohkuma, Toru Takebayashi
AIM: Accumulating evidence suggests that predictability of traditional cardiovascular risk factors declines with advancing age. We investigated whether carotid plaque scores (CPSs) were associated with cardiovascular disease (CVD) death in the oldest old, and whether asymmetrical dimethylarginine (ADMA), a marker of endothelial dysfunction, moderated the association between the CPS and CVD death. METHODS: We conducted a prospective cohort study of Japanese subjects aged ≥85 years without CVD at baseline...
February 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28154896/-meaning-of-oldest-old-for-individuals-and-society-analysis-of-psychological-sociological-gerontological-epidemiological-and-theological-aspects
#7
R Thiesemann
No abstract text is available yet for this article.
February 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28126636/coexisting-severe-frailty-and-malnutrition-predict-mortality-among-the-oldest-old-in-nursing-homes-a-1-year-prospective-study
#8
Tomohiko Kamo, Keita Takayama, Hideaki Ishii, Keisuke Suzuki, Katsuhiko Eguchi, Yuusuke Nishida
The aim of this study was to explore the relationship of coexisting severe frailty and malnutrition with all-cause mortality among the oldest old in nursing homes. This study was conducted among all subjects (n=160) aged 85 years and older who lived in two nursing homes of Japan. Information about the health status of participants was gathered from history, medical documentation, test assessing frailty, according to the Canadian Study of Health and Aging-Clinical Frailty Scale (CSHA-CFS) and the Mini Nutritional Assessment Short Form (MNA-SF)...
January 19, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28125847/-health-insurance-in-old-age-and-differences-in-cognition-depressive-symptoms-and-health-related-quality-of-life
#9
Jens-Oliver Bock, André Hajek, Dagmar Lühmann, Annette Ernst, Silke Mamone, Birgitt Wiese, Siegfried Weyerer, Jochen Werle, Michael Pentzek, Angela Fuchs, Janine Stein, Tobias Luck, Horst Bickel, Dagmar Weeg, Michael Wagner, Martin Scherer, Steffi G Riedel-Heller, Wolfgang Maier, Hans-Helmut König
Objective We aimed at identifying differences regarding cognition, depressive symptoms and health-related quality of life between members of private and statutory health insurance (SHI) in very old age in Germany. Methods Cross-sectional data were gathered from the multicenter prospective "Study on Needs, health service use, costs and health-related quality of life in a large sample of oldest-old primary care patients (85+)" (AgeQualiDe), covering primary care patients aged ≥ 85 years (n = 854; with 773 members of SHI)...
January 26, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/28108119/age-of-onset-of-hypertension-and-risk-of-dementia-in-the-oldest-old-the%C3%A2-90-study
#10
María M Corrada, Kathleen M Hayden, Annlia Paganini-Hill, Szofia S Bullain, Jaime DeMoss, Colette Aguirre, Ron Brookmeyer, Claudia H Kawas
INTRODUCTION: We investigated the association between age of onset of hypertension and dementia risk in an oldest-old cohort. METHODS: Participants are from The 90+ Study, a population-based longitudinal study of people aged 90+ who are survivors from the Leisure World Cohort Study. We estimated hypertension onset age using self-reported information from The 90+ Study and Leisure World Cohort Study, collected about 20 years earlier. A total of 559 participants without dementia were followed every 6 months for up to 10 years...
February 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28071922/anxiety-symptoms-and-risk-of-dementia-and-mild-cognitive-impairment-in-the-oldest-old-women
#11
Ahmed M Kassem, Mary Ganguli, Kristine Yaffe, Joseph T Hanlon, Oscar L Lopez, John W Wilson, Kristine Ensrud, Jane A Cauley
OBJECTIVES: Research is limited and findings conflict regarding anxiety as a predictor of future cognitive decline in the oldest old persons. We examined the relationship between levels of and changes in anxiety symptoms, and subsequent dementia and mild cognitive impairment (MCI) in the oldest old women. METHOD: We conducted secondary analyses of data collected from 1425 community-dwelling women (mean age = 82.8, SD ±3.1 years) followed on average for five years...
January 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28032231/outcome-following-surgical-treatment-of-chronic-subdural-hematoma-in-the-oldest-old-population
#12
Christopher Munoz-Bendix, Robert Pannewitz, Daniel Remmel, Hans-Jakob Steiger, Bernd Turowski, Phillip Jorg Slotty, Marcel Alexander Kamp
As a result of the demographic shift in western societies, the mean age at presentation of patients suffering from chronic subdural hematomas (cSDH) is increasing. Therapeutic strategies, surgical and non-surgical, need to be reevaluated and adapted accordingly. Age is considered to be a positive risk factor for a higher perioperative morbidity and mortality. The purpose of this study is to determine if old age (≥85 years) should be seen as a contraindication for surgical treatment. Two groups (56 patients each) with cSDH over and below 85 years of age from a single neurosurgical department with well-defined surgical treatment guidelines were retrospectively analyzed...
December 28, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/28032140/verbal-and-visual-divergent-thinking-in-aging
#13
Massimiliano Palmiero, Raffaella Nori, Laura Piccardi
According to the peak and decline model divergent thinking declines at a specific age (in or after middle age). However, if divergent thinking declines steadily in aging still has to be clarified. In order to explore the age-related changes in verbal and visual divergent thinking, in the present study a sample of 159 participants was divided in five age groups: young adults (18-35 years), middle-aged adults (36-55), young old (56-74), old (75-85) and the oldest-old (86-98). Two divergent thinking tasks were administered: the alternative uses for cardboard boxes, aimed at assessing verbal ideational fluency, flexibility and originality; the completion drawing task, aimed at assessing visual ideational fluency, flexibility and originality...
December 28, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28017957/-development-of-osteoporosis-drugs-the-past-the-present-and-the-future
#14
Shinya Tanaka
From 1990s to 2000s, new drugs for osteoporosis have been developed, and the bone metabolism researches have livened up. In those days, many a people gathered to the meeting from many countries, and the each booth of pharmaceutics was proud of its preeminence. The dedications by the society and its members have had osteoporosis diagnostics developed, the anchor drugs become prevalent, and the number of fractures reduced. Although the brilliant effects of Romosozumab and Abaloparatide were presented in the meeting held this year, the members had to accept the convergence state of new drug developments...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28011804/shape-of-the-association-between-income-and-mortality-a-cohort-study-of-denmark-finland-norway-and-sweden-in-1995-and-2003
#15
Laust H Mortensen, Johan Rehnberg, Espen Dahl, Finn Diderichsen, Jon Ivar Elstad, Pekka Martikainen, David Rehkopf, Lasse Tarkiainen, Johan Fritzell
OBJECTIVES: Prior work has examined the shape of the income-mortality association, but work has not compared gradients between countries. In this study, we focus on changes over time in the shape of income-mortality gradients for 4 Nordic countries during a period of rising income inequality. Context and time differentials in shape imply that the relationship between income and mortality is not fixed. SETTING: Population-based cohort study of Denmark, Finland, Norway and Sweden...
December 23, 2016: BMJ Open
https://www.readbyqxmd.com/read/27995743/anticholinergic-exposure-in-a-cohort-of-adults-aged-80-years-and-over-associations-of-the-marante-scale-with-mortality-and-hospitalisation
#16
Maarten Wauters, Therese Klamer, Monique Elseviers, Bert Vaes, Olivia Dalleur, Jan Degryse, Carlos Durán, Thierry Christiaens, Majda Azermai, Robert Vander Stichele
Anticholinergics are frequently prescribed for older adults and can lead to adverse drug events. The novel MARANTE (Muscarinic Acetylcholinergic Receptor ANTagonist Exposure) scale measures the anticholinergic exposure by incorporating potency and dosages of each medication into its calculations. The aims were to assess prevalence and intensity of the anticholinergic exposure in a longitudinal cohort study of community-dwelling patients aged 80 years and over (n=503) and to study the impact on mortality and hospitalisation...
December 20, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27968835/psychological-wellbeing-and-all-cause-mortality-in-the-oldest-old-in-china-a-longitudinal-survey-based-study
#17
Enying Gong, Yechu Hua, Lijing L Yan
BACKGROUND: Although the relationship between psychological wellbeing and physical health has been the subject of many studies among middle-aged and older adults, little is known about whether psychological wellbeing is associated with mortality among the fastest growing population segment-the oldest old (aged ≥80 years). METHODS: This study included 18 676 adults aged 80-122 years from the Chinese Longitudinal Healthy Longevity Survey, conducted in 22 of 31 provinces in China in 1998 and followed up in 2000, 2002, 2005, 2008-2009, 2011-12, and 2014...
October 2016: Lancet
https://www.readbyqxmd.com/read/27966402/-colorectal-cancer-surgery-in-the-oldest-dutch-patients-retrospective-analysis-of-two-national-databases-covering-2011-and-2012
#18
N M Verweij, A H W Schiphorst, H A Maas, D D E Zimmerman, F van den Bos, A Pronk, I H M Borel Rinkes, M E Hamakers
OBJECTIVE: Adequate decision-making concerning elderly patients with colorectal cancer requires accurate information regarding the risks of treatment. We analysed the post-operative outcomes and survival following colorectal resections in the oldest old patients (≥ 85 years old). DESIGN: Retrospective study. METHOD: We analysed the data from 2011 and 2012 of all patients with colorectal carcinoma, stage I-III, from two national databases, namely the Dutch Surgical Colorectal Audit registry (DSCA) and the Netherlands Cancer Registry (NKR)...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27965430/timing-of-percutaneous-endoscopic-gastrostomy-for-acute-ischemic-stroke-an-observational-study-from-the-us-nationwide-inpatient-sample
#19
Benjamin P George, Adam G Kelly, George P Albert, David Y Hwang, Robert G Holloway
BACKGROUND AND PURPOSE: Stroke guidelines recommend time-limited trials of nasogastric feeding prior to percutaneous endoscopic gastrostomy (PEG) tube placement. We sought to describe timing of PEG placement and identify factors associated with early PEG for acute ischemic stroke. METHODS: We designed a retrospective observational study to examine time to PEG for ischemic stroke admissions in the Nationwide Inpatient Sample, 2001 to 2011. We defined early PEG placement as 1 to 7 days from admission...
December 13, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27932078/the-utility-of-vacuum-assisted-closure-therapy-for-skin-necrosis-secondary-to-cervical-abscess-in-the-elderly
#20
Tadataka Tsuji, Koichi Satoh, Emi Okuno, Akiko Sobue, Yoshiya Nishide, Susumu Tanaka, Mikihiko Kogo
Vacuum-assisted closure (VAC) systems have been used as negative-pressure dressings in various fields, including decubitus ulcer, trauma, and wound dehiscence. To the best of our knowledge, few reports have examined the utility of VAC therapy for neck abscess in an oldest-old patient. We present here a rare case of neck abscess secondary to parotid abscess, resulting in extensive skin necrosis. Successful management included emergency drainage following epithelial induction through a VAC system without using skin grafting...
December 5, 2016: Auris, Nasus, Larynx
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