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Thiago Cardoso Vale, Maira Tonidandel Barbosa, Elisa de Paula França Resende, Débora Palma Maia, Mauro César Quintão Cunningham, Henrique Cerqueira Guimarães, João Carlos Barbosa Machado, Antônio Lucio Teixeira, Francisco Cardoso, Paulo Caramelli
INTRODUCTION: Parkinsonism is one of the most prevalent neurological syndromes in the elderly. There are only a few epidemiological studies focusing on parkinsonism in oldest-old individuals, particularly in Latin America. This study aims to investigate the prevalence and characteristics of parkinsonism in subjects aged 75 + years living in the community. METHODS: The Pietà study is a population-based investigation on brain aging conducted in Caeté, southeast Brazil...
June 19, 2018: Parkinsonism & related Disorders
Inna Tzoran, Ron Hoffman, Manuel Monreal
There is a growing proportion of the elderly population in the Western world, and these individuals require special considerations regarding a broad variety of aspects, including treatment approaches to illnesses that affect all age groups. The hemostatic system in individuals changes considerably with aging. Specifically, changes in levels of procoagulant and natural anticoagulant factors along with thrombopathy simultaneously create a hypercoagulable state and hemostatic difficulties. Underlying morbidities, such as congestive heart failure, chronic obstructive pulmonary disease, diabetes mellitus, and cancer, increase the risk for venous and arterial thrombosis...
June 19, 2018: Seminars in Thrombosis and Hemostasis
John L Robinson, Maria M Corrada, Gabor G Kovacs, Myrna Dominique, Carrie Caswell, Sharon X Xie, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowski
The diagnosis of Alzheimer's disease (AD) in the oldest-old is complicated by the increasing prevalence of age-related neurofibrillary tangles, plaques and non-AD pathologies such as cerebrovascular disease (CVD), hippocampal sclerosis (HS), aging-related tau astrogliopathy (ARTAG), as well as TDP-43 and Lewy pathology. The contribution of these non-AD pathologies to dementia and cognitive resilience is unclear. We assessed the level of AD neuropathologic change (ADNPC) and non-AD pathology in 185 participants enrolled in The 90+ Study with available cognitive assessments and brain tissue...
June 18, 2018: Acta Neuropathologica
L García-Agudo, M Rodríguez-Iglesias, R Carranza-González
OBJECTIVE: Candiduria is increasingly frequent in hospitalized debilitated patients. We aimed to evaluate the approach of clinicians to candiduria in the oldest old, and its effect on clearance and mortality. MATERIAL AND METHODS: An observational study without intervention was carried out during 2012 and 2013 in three Spanish hospitals over patients with nosocomial candiduria aged 80 and over. Following a diagnostic algorithm, we assessed the appropriateness of antifungal therapy and analyzed the impact of the clinical approach (antifungal therapy, antibiotics discontinuation and catheter removal or replacement) on the outcome (mortality at 60 days and resolution, persistence or recurrence of candiduria)...
June 8, 2018: Journal de Mycologie Médicale
Carlos Rodríguez-Pascual, Ivett Torres-Torres, Alejandro Gómez-Quintanilla, Ana Isabel Ferrero-Martínez, Jagdish Sharma, Alba Guitián, Maria Carmen Basalo, Marina Montero-Magan, Arturo Vilches-Moraga, Maria-Teresa Olcoz-Chiva, Emilio Paredes-Galán, Fernando Rodríguez-Artalejo
OBJECTIVE: The safety of direct oral anticoagulants (DOACs) in oldest old patients with nonvalvular atrial fibrillation (NVAF) in daily clinical practice has not been systematically assessed. This study examined the safety of DOACs and dicumarol (a vitamin K antagonist) in NVAF geriatric patients. DESIGN: Prospective study from January 2010 through June 2015, with follow-up through January 2016. SETTING: Geriatric medicine department at a tertiary hospital...
June 8, 2018: Journal of the American Medical Directors Association
Tina Mallon, Annette Ernst, Christian Brettschneider, Hans-Helmut König, Tobias Luck, Susanne Röhr, Siegfried Weyerer, Jochen Werle, Edelgard Mösch, Dagmar Weeg, Angela Fuchs, Michael Pentzek, Luca Kleineidam, Kathrin Heser, Steffi Riedel-Heller, Wolfgang Maier, Birgitt Wiese, Martin Scherer
BACKGROUND: The prevalence of pain is very common in the oldest age group. Managing pain successfully is a key topic in primary care, especially within the ageing population. Different care settings might have an impact on the prevalence of pain and everyday life. METHODS: Participants from the German longitudinal cohort study on Needs, Health Service Use, Costs and Health-related Quality of Life in a large Sample of Oldest-old Primary Care Patients (85+) (AgeQualiDe) were asked to rate their severity of pain as well as the impairment with daily activities...
June 9, 2018: BMC Family Practice
Yue-Bin Lv, Xiang Gao, Zhao-Xue Yin, Hua-Shuai Chen, Jie-Si Luo, Melanie Sereny Brasher, Virginia Byers Kraus, Tian-Tian Li, Yi Zeng, Xiao-Ming Shi
OBJECTIVE: To examine the associations of blood pressure with all cause mortality and cause specific mortality at three years among oldest old people in China. DESIGN: Community based, longitudinal prospective study. SETTING: 2011 and 2014 waves of the Chinese Longitudinal Healthy Longevity Survey, conducted in 22 Chinese provinces. PARTICIPANTS: 4658 oldest old individuals (mean age 92.1 years). MAIN OUTCOME MEASURES: All cause mortality and cause specific mortality assessed at three year follow-up...
June 5, 2018: BMJ: British Medical Journal
Linda Enroth, Mari Aaltonen, Jani Raitanen, Lily Nosraty, Marja Jylhä
Long-term care (LTC) use increases with ageing due to an age-related increase in disability. Both the levels of disability and social resources vary among socioeconomic groups. The association of socioeconomic status with LTC use is largely unexplored for the oldest old. This study examined how occupational class is associated with LTC use among nonagenarians in the context of universal care coverage. A population-based prospective cohort study with 2862 participants who answered the Vitality 90 + Study surveys in 2001, 2003, 2007, or 2010 in Tampere, Finland, was combined with national register data on LTC use...
June 2018: European Journal of Ageing
Yue-Bin Lv, Simin Liu, Zhao-Xue Yin, Xiang Gao, Virginia Byers Kraus, Chen Mao, Jin-Qiu Yuan, Juan Zhang, Jie-Si Luo, Hua-Shuai Chen, Yi Zeng, Xiao-Ming Shi
OBJECTIVE: Current international and national guidelines for body mass index (BMI) and waist circumference (WC) have been recommended to all adults. However, whether recommendations applied to the oldest old (aged 80+) is poorly known. The study objective was to investigate the relation of BMI and WC with 3-year all-cause mortality among the oldest old. DESIGN, SETTING, AND PARTICIPANTS: A total of 4361 Chinese oldest old (mean age 91.8) participated in this community-based prospective cohort study...
May 25, 2018: Journal of the American Medical Directors Association
A Hajek, C Brettschneider, H van den Bussche, H Kaduszkiewicz, A Oey, B Wiese, S Weyerer, J Werle, A Fuchs, M Pentzek, J Stein, T Luck, H Bickel, E Mösch, K Heser, M Bleckwenn, M Scherer, S G Riedel-Heller, W Maier, H-H König
OBJECTIVES: The aim of this study was to identify determinants of outpatient health care utilization among the oldest old in Germany longitudinally. DESIGN: Multicenter prospective cohort "Study on Needs, health service use, costs and health-related quality of life in a large sample of oldest-old primary care patients (85+)" (AgeQualiDe). SETTING: Individuals in very old age were recruited via GP offices at six study centers in Germany...
2018: Journal of Nutrition, Health & Aging
Janine Stein, Jonathan Michael Bär, Hans-Helmut König, Matthias Angermeyer, Steffi G Riedel-Heller
OBJECTIVE: Loss experiences in old age are common and can be accompanied by serious consequences such as depression. This study aimed at investigating the distribution of loss experiences and their association with depression in old age. METHODS: Based on the Leipzig Longitudinal Study of the Aged 75+ (LEILA 75+), a sample of 706 individuals was assessed via structured clinical interviews. Data on social loss experiences were collected via the Leipziger Lebensereignis-Liste...
May 25, 2018: Psychiatrische Praxis
Julius Halaschek-Wiener, Lauren C Tindale, Jennifer A Collins, Stephen Leach, Bruce McManus, Kenneth Madden, Graydon Meneilly, Nhu D Le, Joseph M Connors, Angela R Brooks-Wilson
BACKGROUND: To understand why some people live to advanced age in good health and others do not, it is important to study not only disease, but also long-term good health. The Super-Seniors Study aims to identify factors associated with healthy aging. METHODS: 480 healthy oldest-old 'Super-Seniors' aged 85 to 105 years and never diagnosed with cancer, cardiovascular disease, diabetes, dementia, or major pulmonary disease, were compared to 545 mid-life controls aged 41-54, who represent a group that is unselected for survival from late-life diseases...
2018: PloS One
Paolo Mazzola, Patrizia Floris, Domenico Picone, Alessandra Anzuini, Eleni Tsiantouli, Justin Haas, Giuseppe Bellelli, Francesco De Filippi, Giorgio Annoni
AIM: Literature investigating rehabilitation outcomes after hip surgery among individuals aged ≥85 years is sparse. We compared the characteristics and outcomes of patients aged under and over 85 years, and assessed factors potentially associated with rehabilitation success as described by the Barthel Index (BI). METHODS: From 2011 to 2014, we prospectively enrolled 328 patients (n = 152 aged <85 years, n = 176 aged ≥85 years) admitted to an orthogeriatric unit (Sondrio, Italy) with a diagnosis of hip fracture requiring surgical treatment...
May 22, 2018: Geriatrics & Gerontology International
Xiaoqian Hu, Yuhang Zeng, Xuemei Zhen, Hao Zhang, Yuanyuan Li, Shuyan Gu, Hengjin Dong
Objectives This study was performed to describe the health status of Chinese oldest-old individuals aged ≥80 years from 1998 to 2014 and explore differences in their health status based on demographic characteristics and socioeconomic status. Methods Data were obtained from the seven waves of the Chinese Longitudinal Healthy Longevity Survey. The Mini Mental State Examination, Katz Index of Independence in Activities of Daily Living, and chair stand test were used to examine cognitive and physical function...
January 1, 2018: Journal of International Medical Research
Celeste Marsh, Paul A Agius, Gamini Jayakody, Roshan Shajehan, Chandima Abeywickrema, Kelly Durrant, Stanley Luchters, Wendy Holmes
BACKGROUND: Populations of low and middle-income countries are ageing rapidly; there is a need for policies that support an increase in the duration of old age lived in good health. There is growing evidence that social participation protects against morbidity and mortality, but few studies explore patterns of social participation. Analysis of baseline quantitative and qualitative data from a trial of the impact of Elders' Clubs on health and well-being in the hill country of Sri Lanka provided an opportunity to better understand the extent of, and influences on, social participation among elders...
May 16, 2018: BMC Public Health
Sven Streit, Rosalinde K E Poortvliet, Jacobijn Gussekloo
Background: the appropriateness of lowering systolic blood pressure remains controversial in the oldest-old. We tested whether systolic blood pressure is associated with all-cause mortality and change in cognitive function for patients prescribed antihypertensive treatment and those without treatment. Methods: we studied participants in the population-based Leiden 85-plus cohort study. Baseline systolic blood pressure and use of antihypertensive treatment were predictors; all-cause mortality and change in cognitive function measured using the Mini-Mental State Examination were the outcomes...
May 8, 2018: Age and Ageing
Young Ho Park
No abstract text is available yet for this article.
May 7, 2018: Journal of Korean Medical Science
Eun-Ye Lim, Dong-Won Yang, Jung-Seok Kim, A-Hyun Cho
Background: There are debates on representation and generalizability of previous randomized controlled trials about anti-dementia agents in the oldest old population. In this context, we aimed to investigate the efficacy and safety of anti-dementia agents in the very elderly patients with dementia. Methods: We conducted a retrospective study of patients with dementia 1) who were 85 years or older, 2) got started anti-dementia agents, and 3) went through follow-up evaluation about one year thereafter...
May 7, 2018: Journal of Korean Medical Science
Zarui A Melikyan, Dana E Greenia, Maria M Corrada, Marilyn M Hester, Claudia H Kawas, Joshua D Grill
No abstract text is available yet for this article.
May 4, 2018: Alzheimer Disease and Associated Disorders
Ryszard Zarzeczny, Agnieszka Nawrat-Szołtysik, Anna Polak, Ahmed Manasar, Jakub Maliszewski, Adam Kiełtyka, Beata Matyja, Magdalena Dudek, Joanna Zborowska, Adam Wajdman
BACKGROUND: Interleukin-6 (IL-6) production facilitates a shift from acute to chronic inflammation that may induce the development of some diseases and aging. Several studies have suggested that adiposity is closely related to serum IL-6 level, but their authors examined relatively young older adults (aged 60-80 years), so it is not clear whether this association would also occur in people at a more advanced age. OBJECTIVE: to assess whether in elderly women without inflammation the widely used anthropometric obesity indices are associated with serum IL-6 level and, if so, to determine the best anthropometric predictor of this inflammatory biomarker...
May 3, 2018: Experimental Gerontology
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