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https://www.readbyqxmd.com/read/28527525/age-related-white-matter-integrity-differences-in-oldest-old-without-dementia
#1
Ilana J Bennett, Dana E Greenia, Pauline Maillard, S Ahmad Sajjadi, Charles DeCarli, Maria M Corrada, Claudia H Kawas
Aging is known to have deleterious effects on cerebral white matter, yet little is known about these white matter alterations in advanced age. In this study, 94 oldest-old adults without dementia (90-103 years) underwent diffusion tensor imaging to assess relationships between chronological age and multiple measures of integrity in 18 white matter regions across the brain. Results revealed significant age-related declines in integrity in regions previously identified as being sensitive to aging in younger-old adults (corpus callosum, fornix, cingulum, external capsule)...
April 26, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28521552/unmet-needs-in-the-depressed-primary-care-elderly-and-their-relation-to-severity-of-depression-results-from-the-agemoode-study
#2
Sophie Alltag, Janine Stein, Alexander Pabst, Siegfried Weyerer, Jochen Werle, Wolfgang Maier, Lisa Miebach, Martin Scherer, Anne Stark, Birgitt Wiese, Silke Mamone, Hans-Helmut König, Jens-Oliver Bock, Steffi G Riedel-Heller
OBJECTIVES: This study aims at examining the distribution of unmet environmental, physical, social and psychological care needs in a sample of the oldest old primary care patients with different levels of depression severity. Furthermore, the objective of this study was to analyze the association between specific unmet care needs and severity of depression. METHOD: The sample of patients aged 75 years (n = 202) and more was derived from the multicenter prospective cohort study AgeMooDe ('Late-life depression in primary care: Needs, health care utilization and costs')...
May 19, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28511737/suicide-in-older-adults-differences-between-the-young-old-middle-old-and-oldest-old
#3
Yu Wen Koo, Kairi Kõlves, Diego De Leo
BACKGROUND: In the limited research into suicides in older adults, they have been treated as a homogenous group without distinguishing between different age groups. This study aimed to compare differences in sociodemographic variables, recent life events, and mental and physical illnesses between three age groups within older adults who died by suicide: young-old (65-74 years), middle-old (75-84 years), and oldest old (85 years and over) in Queensland, Australia, during the years 2000-2012 (N = 978)...
May 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28502820/cancer-incidence-prevalence-and-mortality-in-the-oldest-old-a-comprehensive-review
#4
REVIEW
Shantell C Nolen, Marcella A Evans, Avital Fischer, Maria M Corrada, Claudia H Kawas, Daniela A Bota
Chronic health conditions are commonplace in older populations. The process of aging impacts many of the world's top health concerns. With the average life expectancy continuing to climb, understanding patterns of morbidity in aging populations has become progressively more important. Cancer is an age-related disease, whose risk has been proven to increase with age. Limited information is published about the epidemiology of cancer and the cancer contribution to mortality in the 85+ age group, often referred to as the oldest-old...
May 11, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28498173/the-meaning-of-confidence-for-older-people-living-with-frailty-a-qualitative-systematic-review
#5
Frazer Underwood, Lisa Burrows, Rod Gegg, Jos M Latour, Bridie Kent
BACKGROUND: In many countries, the oldest old (those aged 85 years and older) are now the fastest growing proportion of the total population. This oldest population will increasingly be living with the clinical condition of frailty. Frailty syndromes negatively impact on the person as they do the healthcare systems supporting them. Within healthcare literature "loss of confidence" is occasionally connected to older people living with frailty, but ambiguously described. Understanding the concept of confidence within the context of frailty could inform interventions to meet this growing challenge...
May 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28487335/to-treat-or-not-to-treat-anticoagulants-as-secondary-preventives-to-the-oldest-old-with-atrial-fibrillation
#6
Peter Appelros, Bahman Farahmand, Andreas Terént, Signild Åsberg
BACKGROUND AND PURPOSE: Anticoagulant treatment is effective for preventing recurrent ischemic strokes in patients who have atrial fibrillation. This benefit is paid by a small increase of hemorrhages. Anticoagulant-related hemorrhages seem to increase with age, but there are few studies showing whether the benefits of treatment persist in old age. METHODS: For this observational study, 4 different registers were used, among them Riksstroke, the Swedish Stroke Register...
May 9, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28470549/epidemic-use-of-benzodiazepines-among-older-adults-in-israel-epidemiology-and-leverage-points-for-improvement
#7
Michael A Steinman, Marcelo Low, Ran D Balicer, Efrat Shadmi
BACKGROUND: Benzodiazepines and benzodiazepine-receptor agonists (BDZRAs, often known as "Z-drugs") are commonly used in older adults despite well-documented harms. OBJECTIVE: To evaluate patterns of benzodiazepine and BDZRA use in Israel, focusing on potential leverage points where quality improvement initiatives might effectively curtail new use or the transition from intermittent to chronic use. DESIGN AND PARTICIPANTS: We used national electronic medical data to assess a 10% random sample of adults receiving care in Clalit Health Services, which serves half of Israel's population...
May 3, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28467211/hippocampal-sclerosis-in-older-patients-practical-examples-and-guidance-with-a-focus-on-cerebral-age-related-tdp-43-with-sclerosis
#8
Matthew D Cykowski, Suzanne Z Powell, Paul E Schulz, Hidehiro Takei, Andreana L Rivera, Robert E Jackson, Gustavo Roman, Gregory A Jicha, Peter T Nelson
CONTEXT: - Autopsy studies of the older population (≥65 years of age), and particularly of the "oldest-old" (≥85 years of age), have identified a significant proportion (∼20%) of cognitively impaired patients in which hippocampal sclerosis is the major substrate of an amnestic syndrome. Hippocampal sclerosis may also be comorbid with frontotemporal lobar degeneration, Alzheimer disease, and Lewy body disease. Until recently, the terms hippocampal sclerosis of aging or hippocampal sclerosis dementia were applied in this context...
May 3, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28453475/modifiable-risk-factors-for-prevention-of%C3%A2-dementia-in-midlife-late-life-and-the-oldest-old-validation-of-the-libra-index
#9
Stephanie J B Vos, Martin P J van Boxtel, Olga J G Schiepers, Kay Deckers, Marjolein de Vugt, Isabelle Carrière, Jean-François Dartigues, Karine Peres, Sylvaine Artero, Karen Ritchie, Lucia Galluzzo, Emanuele Scafato, Giovanni B Frisoni, Martijn Huisman, Hannie C Comijs, Simona F Sacuiu, Ingmar Skoog, Kate Irving, Catherine A O'Donnell, Frans R J Verhey, Pieter Jelle Visser, Sebastian Köhler
BACKGROUND: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual's prevention potential for dementia. OBJECTIVE: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old. METHODS: 9,387 non-demented individuals were recruited from the European population-based DESCRIPA study. An individual's LIBRA index was calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28436390/biomarkers-for-early-diagnosis-of%C3%A2-alzheimer-s-disease-in-the-oldest-old-yes-or-no
#10
Lucia Paolacci, David Giannandrea, Patrizia Mecocci, Lucilla Parnetti
In recent years, many efforts have been spent to identify sensitive biomarkers able to improve the accuracy of Alzheimer's disease (AD) diagnosis. Two different workgroups (NIA-AA and IWG) included cerebrospinal fluid (CSF) and neuroimaging findings in their sets of criteria in order to improve diagnostic accuracy as well as early diagnosis. The number of subjects with cognitive impairment increases with aging but the oldest old (≥85 years of age), the fastest growing age group, is still the most unknown from a biological point of view...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28436187/slow-gait-speed-as-a-predictor-of-1-year-cognitive-decline-in-a-veterans-retirement-community-in-southern-taiwan
#11
Chiao-Lin Hsu, Chih-Kuang Liang, Mei-Chen Liao, Ming-Yueh Chou, Yu-Te Lin
AIM: Slow gait speed has been associated with mortality, poor physical function and disability in older people. Our aim was to evaluate the association between slow gait speed and rapid cognitive decline among oldest-old men in Taiwan. METHODS: We carried out a longitudinal cohort study in a veterans' retirement community, and enrolled 249 male residents aged 80 years and older. Slow gait speed was defined as <1 m/s, and rapid cognitive decline was defined as a Mini-Mental State Examination (MMSE) decline of ≥3 points over 1 year...
April 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28431552/strategies-to-improve-engagement-of-hard-to-reach-older-people-in-research-on-health-promotion-a-systematic-review
#12
Ann E M Liljas, Kate Walters, Ana Jovicic, Steve Iliffe, Jill Manthorpe, Claire Goodman, Kalpa Kharicha
BACKGROUND: This systematic review aimed to identify facilitators, barriers and strategies for engaging 'hard to reach' older people in research on health promotion; the oldest old (≥80 years), older people from black and minority ethnic groups (BME) and older people living in deprived areas. METHODS: Eight databases were searched to identify eligible studies using quantitative, qualitative, and mixed research methods. Using elements of narrative synthesis, engagement strategies, and reported facilitators and barriers were identified, tabulated and analysed thematically for each of the three groups of older people...
April 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28427345/variation-in-gp-decisions-on-antihypertensive-treatment-in-oldest-old-and-frail-individuals-across-29-countries
#13
Sven Streit, Marjolein Verschoor, Nicolas Rodondi, Daiana Bonfim, Robert A Burman, Claire Collins, Gerasimovska Kitanovska Biljana, Sandra Gintere, Raquel Gómez Bravo, Kathryn Hoffmann, Claudia Iftode, Kasper L Johansen, Ngaire Kerse, Tuomas H Koskela, Sanda Kreitmayer Peštić, Donata Kurpas, Christian D Mallen, Hubert Maisoneuve, Christoph Merlo, Yolanda Mueller, Christiane Muth, Marija Petek Šter, Ferdinando Petrazzuoli, Thomas Rosemann, Martin Sattler, Zuzana Švadlenková, Athina Tatsioni, Hans Thulesius, Victoria Tkachenko, Peter Torzsa, Rosy Tsopra, Tuz Canan, Rita P A Viegas, Shlomo Vinker, Margot W M de Waal, Andreas Zeller, Jacobijn Gussekloo, Rosalinde K E Poortvliet
BACKGROUND: In oldest-old patients (>80), few trials showed efficacy of treating hypertension and they included mostly the healthiest elderly. The resulting lack of knowledge has led to inconsistent guidelines, mainly based on systolic blood pressure (SBP), cardiovascular disease (CVD) but not on frailty despite the high prevalence in oldest-old. This may lead to variation how General Practitioners (GPs) treat hypertension. Our aim was to investigate treatment variation of GPs in oldest-olds across countries and to identify the role of frailty in that decision...
April 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28427051/subjective-time-perceptions-and-aging-well-a-review-of-concepts-and-empirical-research-a-mini-review
#14
Martina Gabrian, Anne J Dutt, Hans-Werner Wahl
Human beings impose subjective, time-related interpretations on their existence, and the experience of time is a major aspect of lifespan development. In this mini-review, we understand subjective time as the way individuals subjectively perceive and evaluate the passing of their personal "objective" lifetime. A broad range of constructs and operationalizations has been developed in (gero-) psychology to capture subjective time, including future time perspective, personal goals, or autobiographical memories...
April 21, 2017: Gerontology
https://www.readbyqxmd.com/read/28410660/late-onset-alzheimer-disease
#15
REVIEW
Aimee L Pierce, Szofia S Bullain, Claudia H Kawas
The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease...
May 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28407800/advance-directives-and-power-of-attorney-for-health-care-in-the-oldest-old-results-of-the-agequalide-study
#16
Tobias Luck, Francisca S Rodriguez, Birgitt Wiese, Carolin van der Leeden, Kathrin Heser, Horst Bickel, Jürgen In der Schmitten, Hans-Helmut Koenig, Siegfried Weyerer, Silke Mamone, Tina Mallon, Michael Wagner, Dagmar Weeg, Angela Fuchs, Christian Brettschneider, Jochen Werle, Martin Scherer, Wolfgang Maier, Steffi G Riedel-Heller
BACKGROUND: Completion of advance directives (ADs) and power of attorney (POA) documents may protect a person's autonomy in future health care situations when the individual lacks decisional capacity. As such situations become naturally much more common in old age, we specifically aimed at providing information on (i) the frequency of ADs/POA in oldest-old individuals and (ii) factors associated with having completed ADs/POA. METHODS: We analyzed data of oldest-old primary care patients (85+ years; including community-dwelling and institutionalized individuals) within the German AgeQualiDe study...
April 13, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28391702/aging-with-purpose
#17
Justine Irving, Sandra Davis, Aileen Collier
Purpose can provide a sense of intentionality, guide behavior to achieve personal aims and living objectives, and may offer insight into how and why certain people remain healthy over time. A review of the literature sought to identify contemporary research pertaining to purpose and older adults. Thirty-one studies were selected for evaluation based on inclusion criteria. Research outcomes suggest that greater reported purpose is related to a range of better health and well-being outcomes for older adults. With few exceptions, the literature demonstrates that purpose declines with age...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28389834/chronic-subdural-hematoma-in-the-oldest-old-population
#18
REVIEW
Miguel Gelabert-González, Paula Román-Pena, Eduardo Arán-Echabe
No abstract text is available yet for this article.
April 7, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28386536/the-otago-exercise-program-innovative-delivery-models-to-maximize-sustained-outcomes-for-high-risk-homebound-older-adults
#19
Tiffany E Shubert, Lavinia Spring Goto, Matthew Lee Smith, Luohua Jiang, Holly Rudman, Marcia G Ory
BACKGROUND: It is estimated one in two adults age 80 and over fall each year, resulting in substantial morbidity and mortality rates among this oldest-old population. The Otago Exercise program (OEP) is an evidence-based fall prevention program shown to reduce falls by 35% among high-risk older adults. The OEP was designed to be delivered in the home by physical therapists. This model has encountered multiple implementation challenges in the United States health-care system, which has resulted in the development and testing of innovative models to support a broader reach and dissemination of this program...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28385481/rehabilitation-services-use-and-patient-reported-outcomes-among-older-adults-in-the-united-states
#20
Nancy M Gell, Tracy M Mroz, Kushang V Patel
OBJECTIVE: To characterize rehabilitation service use among community-dwelling older adults in the United States by identifying predictors of rehabilitation utilization, patient-reported functional improvement, and rehabilitation goal attainment. DESIGN: Cross-sectional analysis of the 2015 National Health and Aging Trends Study, which used an age-stratified, multistage sampling design and oversampled blacks and the oldest old (≥85y). SETTING: Standardized, in-person home interviews and physical performance testing...
April 3, 2017: Archives of Physical Medicine and Rehabilitation
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