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https://www.readbyqxmd.com/read/28521893/pulmonary-hypertension-in-infants-children-and-young-adults
#1
REVIEW
Georg Hansmann
Pulmonary hypertension (PH) in neonates, infants, children, adolescents, and young adults is a complex condition that can be associated with several cardiac, pulmonary, and systemic diseases contributing to morbidity and mortality. The underlying pulmonary hypertensive vascular disease (PHVD) is characterized by inflammation, pulmonary vascular remodeling, and angio-obliteration leading to elevated pulmonary arterial pressure and resistance, right ventricular dysfunction, left ventricular compression, and subsequent heart failure...
May 23, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28520545/hemodynamic-profile-of-acute-kidney-injury-following-the-fontan-procedure-impact-of-renal-perfusion-pressure
#2
Taylor Patterson, David A Hehir, Matthew Buelow, Pippa M Simpson, Michael E Mitchell, Liyun Zhang, Mehdi Eslami, Kathleen Murkowski, John P Scott
BACKGROUND: Acute kidney injury (AKI) is common following cardiopulmonary bypass. Fontan completion may result in systemic venous hypertension and low cardiac output, reducing renal perfusion pressure (RPP) and further increasing the risk of AKI. We investigated the incidence and risk factors for post-Fontan AKI. METHODS: Single-center retrospective study of children undergoing Fontan completion from 2005 to 2012. Demographic and hemodynamic variables were assessed for association with AKI...
May 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28511153/-morbidity-rate-of-obesity-in-children-in-ukraine-overweight-as-noncontagious-disease-risk-factor
#3
Ірина Е Заболотна
INTRODUCTION: The upsurge of prevalence rate of obesity and overweight that in the majority of cases traces back to childhood is a risk factor of the most common noncontagious diseases in adults. THE AIM: The aim was to analyze prevalence of obesity in children in Ukraine and to conduct the pilot study of medical condition of overweight children. MATERIALS AND METHODS: Official state statistics of prevalence rate of obesity in kids and screening data of anthropometric characteristics, arterial tension levels, physical performance decrement and medical condition of children (boys - 50, girls - 90, average age - 15,1±0,1 years) was used in research...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28508156/pulse-wave-velocity-measurement-as-a-marker-of-arterial-stiffness-in-pediatric-inflammatory-bowel-disease-a-pilot-study
#4
Eberhard Lurz, Eliane Aeschbacher, Nicholas Carman, Susanne Schibli, Christiane Sokollik, Giacomo D Simonetti
In adults with inflammatory bowel disease (IBD), the incidence of cardiovascular events is increased, leading to long-term morbidity. Arterial stiffness (AS) measured by pulse wave velocity (PWV) is a validated early precursor of cardiovascular disease (CVD), and measurement of PWV was shown to be a feasible test in children. The aim of this study was to assess AS in children with IBD. In this prospective study, we determined PWV between the carotid and femoral artery (PWVcf) in 25 children and adolescents with IBD (11 females, median age 14...
May 15, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28501727/methods-to-evaluate-arterial-structure-and-function-in-children-state-of-the-art-knowledge
#5
REVIEW
Piotr Skrzypczyk, Małgorzata Pańczyk-Tomaszewska
BACKGROUND: With increasing rates of hypertension, obesity, and diabetes in the pediatric population, wide available, and reproducible methods are necessary to evaluate arterial structure and function in children and adolescents. METHODS: MEDLINE/Pubmed was searched for articles published in years 2012-2017 on methodology of, current knowledge on, and limitations of the most commonly used methods to evaluate central, proximal and coronary arteries, as well as endothelial function in pediatric patients...
May 11, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28497191/evaluation-of-the-coronary-circulation-and-calcification-in-children-on-regular-hemodialysis
#6
Mohammed Al-Biltagi, Maher Ahmed Abd ElHafez, Doaa Mohamed El Amrousy, Mohamed El-Gamasy, Hesham El-Serogy
BACKGROUND: The objective of this study was to evaluate the coronary circulation and calcification in children with end-stage renal disease (ESRD) on hemodialysis. METHODS: A total of 50 children with ESRD and 50 healthy controls were enrolled in the study. Cardiac functions and coronary blood flow were evaluated with conventional and tissue Doppler echocardiography. Coronary artery calcification (CAC) was evaluated using high-resolution multidetector computed tomography (CT)...
May 11, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28496512/takayasu-s-arteritis-presenting-with-headache-and-peripheral-facial-palsy-a-case-report
#7
Maryam Sotoudeh Anvari, Farzad Masoudkabir, Kyomars Abbasi, Mohammad Ali Boroumand, Manijeh Zarghampour, Hamidreza Goodarzynejad
Takayasu's arteritis (TA) is a rare case of granulomatous arteritis which mainly involves the aorta and its large branches. Although arterial hypertension is the most common feature of the disease in both adults and children, patients with TA may present with numerous clinical manifestations. Our patient was a 45-year-old woman, known to have hypertension from 3 years earlier following assessments made for severe headache. One year after the diagnosis of hypertension, she developed a left-sided lower motor neuron facial palsy, which was treated with oral corticosteroids (Prednisolone)...
October 3, 2016: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28484878/the-association-between-creatinine-versus-cystatin-c-based-egfr-and-cardiovascular-risk-in-children-with-chronic-kidney-disease-using-a-modified-pday-risk-score
#8
Sheena Sharma, Michelle R Denburg, Susan L Furth
BACKGROUND: Children with chronic kidney disease (CKD) have a high prevalence of cardiovascular disease (CVD) risk factors which may contribute to the development of cardiovascular events in adulthood. Among adults with CKD, cystatin C-based estimates of glomerular filtration rate (eGFR) demonstrate a stronger predictive value for cardiovascular events than creatinine-based eGFR. The PDAY (Pathobiological Determinants of Atherosclerosis in Youth) risk score is a validated tool used to estimate the probability of advanced coronary atherosclerotic lesions in young adults...
May 8, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28475712/surgical-management-of-aortopulmonary-window-24-years-of-experience-and-lessons-learned
#9
Deepak Gowda, Trushar Gajjar, Jinaga Nageswar Rao, Praveen Chavali, Aaditya Sirohi, Naveen Pandarinathan, Neelam Desai
OBJECTIVES: Aortopulmonary window represents 0.2-0.3% of all congenital heart lesions. Progressive pulmonary arterial hypertension and its consequences are more common with this anomaly. The purpose of this study was to share 24 years of surgical experience in managing a spectrum of 55 cases of aortopulmonary window, followed up to 17 years in a single institution. METHODS: : This retrospective study was done from November 1991 to November 2015 of 55 patients with aortopulmonary window who underwent successful surgical repair...
May 5, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28475298/a-modified-noninvasive-screening-protocol-for-pulmonary-hypertension-in-children-with-sickle-cell-disease-who-should-be-sent-for-invasive-evaluation
#10
Christian Lilje, Jordan Harry, Kelly K Gajewski, Renee V Gardner
BACKGROUND: Invasive studies have shown that prevalence and severity of pulmonary hypertension (PH) in patients with sickle cell disease (SCD) tend to be overestimated if based exclusively on Doppler-derived tricuspid regurgitant velocity (TRV) as surrogate noninvasive marker with a cutoff ≥2.5 m/s. OBJECTIVES: We aimed to better define a subgroup of pediatric SCD patients who should be sent for invasive evaluation of pulmonary artery pressure (PAP) based on a modified echocardiographic PH screening protocol that implements evidence from Doppler-catheter comparative studies...
May 5, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28473027/-peripheral-facial-palsy-caused-by-severe-hypertension-in-a-three-year-old-boy
#11
Inge Ring Kofoed, Henriette Møller Christensen
A three-year-old boy was admitted to the children's ward with a newly developed peripheral facial palsy. First examination showed a high blood pressure (BP), but the measurement was initially dismissed as inaccurate. After a few days the boy developed a headache. The BP measurement was replicated, showing 180/120 mmHg, and the boy was treated with antihypertensive medication. Diagnostic imaging showed coarctation of the abdominal aorta and both renal arteries. The boy was finally treated with dilatation of the renal arteries...
April 24, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28449720/evolution-of-blood-pressure-in-children-with-congenital-and-acquired-solitary-functioning-kidney
#12
Riccardo Lubrano, Isotta Gentile, Raffaele Falsaperla, Giovanna Vitaliti, Alessia Marcellino, Marco Elli
BACKGROUND: It is not yet clear if blood pressure and renal function changes evolve differently in children with a congenital or acquired solitary functioning kidney. This study aims to assess if there are any differences between these two types of solitary kidney patients. METHODS: Current research is a retrospective study assessing the evolution of glomerular filtration rate, proteinuria, and blood pressure in clinical records of 55 children with a solitary functioning kidney (37 congenital and 18 acquired)...
April 27, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28437814/assessment-of-early-cardiovascular-risk-in-children-and-adolescents-with-essential-hypertension
#13
Andreja Stelcar, Evgenija Homsak, Natasa Marcun Varda
The aim of our study was to investigate some early markers of hypertensive target organ damage in hypertensive children and adolescents, and to detect those showing most prominent clinical significance. We included 100 children with essential hypertension (EH) and 50 age-matched healthy control children, and evaluated left ventricular mass (LVM), intima-media thickness in the carotid arteries (IMT), pulse wave velocity (PWV), microalbuminuria, biochemical parameters and some adipokines. Statistically significant differences between the 2 groups were observed for HDL-cholesterol, LDL-cholesterol, triglycerides, insulin, uric acid, glucose, apolipoprotein A1, and total adiponectin...
April 24, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28425226/a-review-of-pediatric-pulmonary-hypertension-with-new-guidelines
#14
Serdar Kula, Ayhan Pektaş
This study aims to review pediatric pulmonary hypertension (PH) by comparing the guidelines of the European Society of Cardiology (ESC)/European Respiratory Society (ERS), the American Heart Association (AHA)/American Thoracic Society (ATS), and the European Pediatric Pulmonary Vascular Disease Network (EPPVDN). All three sets of guidelines define PH as having a mean pulmonary artery pressure of ≥25 mmHg and accept the validity of the World Health Organization (WHO) classification system. Every child with a high index of suspicion for PH should undergo an initial work-up of chest X-rays, electrocardiography, and echocardiography...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28416004/clinical-study-of-children-with-takayasu-arteritis-a-retrospective-study-from-a-single-center-in-china
#15
Ye Feng, Xuemei Tang, Mingyue Liu, Juan Zhou, Xiaodong Zhao, Qiu Li
BACKGROUND: Delayed diagnosis of childhood Takayasu arteritis (TA) is common due to its atypical symptoms. The objective of the present study was to summarize the clinical features of childhood TA to raise awareness and improve management. METHODS: Eleven children diagnosed with TA at our hospital were enrolled. Clinical information, diagnosis, treatment, and outcome were then examined retrospectively. The Pediatric Vasculitis Activity Score (PVAS) and the Indian Takayasu Clinical Activity Score (ITAS2010) were used to assess disease activity...
April 17, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28406083/ambulatory-arterial-stiffness-index-blood-pressure-variability-and-nocturnal-blood-pressure-dip-in-children-with-iga-and-henoch-sch%C3%A3-nlein-nephropathy%C3%A2
#16
Piotr Skrzypczyk, Małgorzata Mizerska-Wasiak, Barbara Jerszow, Paweł Ruszczykowski, Małgorzata Pańczyk-Tomaszewska
AIM: Evaluation of mean blood pressure values, ambulatory arterial stiffness index (AASI), pulse pressure (PP), blood pressure variability (BPV), and circadian blood pressure rhythm using ambulatory blood pressure monitoring (ABPM) in children with IgA nephropathy and Henoch-Schönlein nephropathy (IgAN/HSN). MATERIAL AND METHODS: In 48 children (29 with IgAN, 19 with HSN) aged 14.04 ± 3.76 years, we evaluated retrospectively 24-hour systolic and diastolic BP (24hSBP, 24hDBP), AASI, PP, systolic and diastolic BPV, and nocturnal BP dip by ABPM, body mass index (BMI) Z-score, medications, and biochemical parameters...
April 13, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28402974/cardiac-changes-and-their-association-with-fetuin-a-and-fibroblast-growth-factor-23-in-children-with-chronic-kidney-disease
#17
Abdullahi Mudi, Hopewell Ntsinjana, Caroline Dickens, Cecil Levy, Daynia Ballot
AIMS: In children with chronic kidney disease (CKD), fetuin-A and fibroblast growth factor-23 (FGF-23) have been implicated in the mechanism and progression of several cardiac changes. This study aimed to determine the types and rates of cardiac changes in children with CKD and their association with fetuin-A, FGF-23, and other cardiovascular risk factors (CVRFs). METHODS: This comparative cross-sectional study recruited 88 children (5-18 years): 27 CKD I with a glomerular filtration rate (GFR) >90 mL/min/1...
April 13, 2017: Nephron
https://www.readbyqxmd.com/read/28378971/environmental-variation-in-the-prevalence-of-hypertension-in-children-and-adolescents-is-blood-pressure-higher-in-children-and-adolescents-living-in-rural-areas
#18
Małgorzata Krzywinska-Wiewiorowska, Barbara Stawińska-Witoszyńska, Alicja Krzyżaniak, Maria Kaczmarek, Aldona Siwinska
INTRODUCTION: Despite considerable progress in diagnostic methods and treatment options, cardiovascular diseases constitute a serious health issue in Poland, and hypertension is considered one of the main risk factors in the incidence of the diseases. OBJECTIVES: The aim of this study is to assess the values of arterial blood pressure among adolescents in the context of urban and rural environments. MATERIALS AND METHOD: The study was carried out on a representative, randomly selected group of youths aged 10-18 years, participating in the ADOPOLNOR project...
March 31, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28370259/regional-right-ventricular-remodeling-and-function-in-children-with-idiopathic-pulmonary-arterial-hypertension-vs-those-with-pulmonary-valve-stenosis-insights-into-mechanics-of-right-ventricular-dysfunction
#19
Mieke M P Driessen, Folkert J Meijboom, Wei Hui, Andreea Dragulescu, Luc Mertens, Mark K Friedberg
BACKGROUND: Right ventricular (RV) pressure overload in the context of pulmonary stenosis (PS) has a much better prognosis than in the context of idiopathic pulmonary arterial hypertension (iPAH), which may be related to differences in global and regional RV remodeling and systolic function. We compared RV mechanics in children with PS to those with iPAH, aiming to identify mechanisms and markers of RV dysfunction. METHODS: Eighteen controls, 18 iPAH and 16 PS patients were retrospectively studied...
April 1, 2017: Echocardiography
https://www.readbyqxmd.com/read/28348599/a-rare-case-of-stroke-secondary-to-iron-deficiency-anemia-in-a-young-female-patient
#20
Kavitha Gopalratnam, Kevin Andrew Woodson, Jigarkumar Rangunwala, Kanaga Sena, Manisha Gupta
Ischemic strokes occur when there is a sudden obstruction of an artery supplying blood flow to an area of the brain, leading to a focal neurological deficit. Strokes can be thrombotic or embolic in etiology and are associated with underlying conditions such as hypertension and atherosclerosis. Possible etiologies of strokes include cardioembolic disease, hematologic disorders, connective tissue disorders, and substance abuse or can be cryptogenic. Most stroke cases are seen in patients over 65 years of age...
2017: Case Reports in Medicine
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