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platelet transfusion recommendation

https://read.qxmd.com/read/38031975/performance-evaluation-of-plt-h-hybrid-channel-platelet-under-various-interferences-and-application-studies-for-platelet-transfusion-decisions
#21
JOURNAL ARTICLE
Qi Cai, Han Lin, Ping Guo
The hybrid-channel platelet counting method (PLT-H) is a new platelet counting technique proposed by Mindray of China. In this study, we aimed to evaluate the accuracy of this technique in various situations and its reliability in platelet transfusion decision-making. A total of 378 venous blood samples were tested. Using the immunological PLT counting method recommended by the International Council for Standardization in Hematology as the reference method (PLT-IRM), Passing-Bablok regression and Bland-Altman analysis were performed on the PLT-H results...
December 2023: Platelets
https://read.qxmd.com/read/37996288/advancing-understandings-of-blood-donation-motivation-and-behavior
#22
REVIEW
Shana D Hughes, Christopher L France, Kamille A West-Mitchell, Theresa Pina, Duncan McElfresh, Merlyn Sayers, Barbara J Bryant
In this review, we provide critical analysis of social science research into blood donation motivation and behavior. We first share an understanding of the existing literature and recommendations for future research collectively developed by members of the Working Group on Blood Donors and the Supply: Diversifying while Maintaining the Donor Pool, Donor Selection, and Optimizing Blood Availability and Safety, as part of the National Heart, Lung, and Blood Institute's 2022 State of the Science in Transfusion Medicine symposium...
October 2023: Transfusion Medicine Reviews
https://read.qxmd.com/read/37986382/platelet-transfusion-for-spontaneous-intracerebral-hemorrhage-with-prior-antiplatelet-a-systematic-review-and-meta-analysis
#23
JOURNAL ARTICLE
Yan Lin, Yong Liu, Lei Liu, Lili Zhang, Yapeng Lin, Jianping Yu, Jie Yang
BACKGROUND: Recent studies have highlighted the unfavorable prognosis of patients with spontaneous intracerebral hemorrhage (ICH) who have received prior antiplatelet therapy (PAP). Platelet infusion therapy (PIT) is commonly administered to such patients at many medical institutions, but its efficacy remains a subject of debate. METHODS: To address this uncertainty, we conducted a comprehensive search of PubMed, EMBASE, and Cochrane Library databases for eligible studies published before June 30, 2023...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37971290/obstructive-uropathy-from-bilateral-ureteric-calculi-in-an-infant-with-diarrhoea-disease
#24
R Aliu, I Jalo, L Olatoke, I Asabe, A Bello
INTRODUCTION: Urolithiasis is the presence of mineral deposits in the urinary tract. It is rare in under-5 children and in Sub-Saharan Africa. Although metabolic abnormality is implicated in 50% of cases, infection, decreased urine volume and flow (dehydration state) have been implicated. We report a case of bilateral ureteric calculi in an infant with diarrhoea disease and dehydration. CASE REPORT: A.S, is an 8-month-old male with prolonged loose, large-volume stool, large-volume vomiting, high-grade fever, body weakness, and peri-orbital swelling that progressed to generalized body swelling and absent urine for 2 days...
November 10, 2023: West African Journal of Medicine
https://read.qxmd.com/read/37893432/artificial-intelligence-and-neurosurgery-tracking-antiplatelet-response-patterns-for-endovascular-intervention
#25
REVIEW
Khushi Saigal, Anmol Bharat Patel, Brandon Lucke-Wold
Platelets play a critical role in blood clotting and the development of arterial blockages. Antiplatelet therapy is vital for preventing recurring events in conditions like coronary artery disease and strokes. However, there is a lack of comprehensive guidelines for using antiplatelet agents in elective neurosurgery. Continuing therapy during surgery poses a bleeding risk, while discontinuing it before surgery increases the risk of thrombosis. Discontinuation is recommended in neurosurgical settings but carries an elevated risk of ischemic events...
September 25, 2023: Medicina
https://read.qxmd.com/read/37868577/spectrum-of-febrile-thrombocytopenia-in-the-pediatric-population-1-18-years-admitted-in-a-tertiary-care-center
#26
JOURNAL ARTICLE
Trupti Deshpande, Harsh B Gupta, Nimisha Pandya, Shruti G Sethia, Lalit Nainiwal, Soumitra Sethia
Aim Thrombocytopenia is a common manifestation of various infections. Thrombocytopenia associated with fever helps to narrow down the differential diagnosis and management of fever. It also helps to know the various complications of thrombocytopenia, its management, and the outcome of the patient. This study aimed to evaluate the clinical profile and determine etiology and complications in patients with fever and thrombocytopenia in pediatric populations. Methods One hundred and fifteen patients of both sexes aged 1-18 years with fever and found to have thrombocytopenia (platelet count < 1...
September 2023: Curēus
https://read.qxmd.com/read/37811680/an-optimized-procedure-for-luminex-based-human-platelet-antigen-specific-antibody-screening-and-identification-paklx-assay-with-a-cost-effective-approach-and-improved-sensitivity
#27
JOURNAL ARTICLE
Gerald Bertrand, Julien Griffon, Virginie Renac
BACKGROUND AND OBJECTIVES: Detection of anti-platelet antibodies is required for the diagnosis of foetal/neonatal alloimmune thrombocytopaenia. The most commonly used methods for anti-platelet antibody detection are the monoclonal antibody-specific immobilization of platelet antigens (MAIPA) and the Luminex bead assay (PakLx). However, for economic reasons, the use of the PakLx assay is limited. MATERIALS AND METHODS: In the present study, we evaluated the performance of an optimized protocol based on a half-volume of PakLx reagents...
October 9, 2023: Vox Sanguinis
https://read.qxmd.com/read/37767284/platelet-rich-fibrin-in-oral-surgery-and-implantology-a-narrative-review
#28
REVIEW
Katharina Zwittnig, Khaled Mukaddam, Daniel Vegh, Valentin Herber, Norbert Jakse, Peter Schlenke, Tomislav Ante Zrnc, Michael Payer
BACKGROUND: The application of blood concentrates has gained popularity in dentistry in recent years. Platelet-rich fibrin (PRF) has been discussed frequently due to a high content of growth factors and the option of chair-side manufacturing in a simple centrifugation process. PRF is free from adjuvants and inexpensive to produce. The number of studies reporting beneficial effects of PRF in various clinical applications such as alveolar ridge preservation, sinus floor elevation, management and prevention of medical-related osteonecrosis of the jaw, third molar extractions, and guided bone regeneration in dentistry has increased recently...
August 2023: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/37689812/diagnostic-and-treatment-guidelines-for-thrombotic-thrombocytopenic-purpura-ttp-in-japan-2023
#29
JOURNAL ARTICLE
Masanori Matsumoto, Yoshitaka Miyakawa, Koichi Kokame, Yasunori Ueda, Hideo Wada, Satoshi Higasa, Hideo Yagi, Yoshiyuki Ogawa, Kazuya Sakai, Toshiyuki Miyata, Eriko Morishita, Yoshihiro Fujimura
Thrombotic thrombocytopenic purpura (TTP) can rapidly become a life-threatening condition, and the importance of its appropriate diagnosis and treatment cannot be overstated. Until recently, TTP has mainly been diagnosed by clinical findings such as thrombocytopenia and hemolytic anemia. In addition to these clinical findings, however, reduced activity of a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) below 10% has become internationally accepted as a diagnostic criterion for TTP...
November 2023: International Journal of Hematology
https://read.qxmd.com/read/37624217/lead-mercury-and-cadmium-concentrations-in-blood-products-transfused-to-neonates-elimination-not-just-mitigation
#30
JOURNAL ARTICLE
Sanaa M Aly, Samar Elfiky, Yasmine G Mohamed, Radwa A M Soliman, Nancy Shalaby, Nicolas Beauval, Jean-Michel Gaulier, Delphine Allorge, Ahmed Omran
Lead (Pb), mercury (Hg), and cadmium (Cd) are identified as potent developmental neurotoxicants. Neonates are the main group receiving multiple blood transfusions. The exposure of neonates to these heavy metals (HMs) can occur through blood transfusions. This study aimed to determine the concentrations of lead (Pb), mercury (Hg), and cadmium (Cd) in various blood products (plasma, platelets, packed red blood cells (pRBCs), and whole blood (WB)) to explore the probability of concurrent exposure of these HMs and to identify the metal load per transfusion with risk assessment...
August 18, 2023: Toxics
https://read.qxmd.com/read/37575614/balanced-resuscitation-and-earlier-mortality-end-points-bayesian-post-hoc-analysis-of-the-proppr-trial
#31
JOURNAL ARTICLE
Daniel Lammers, Omar Rokayak, Rindi Uhlich, Thomas Sensing, Emily Baird, Joshua Richman, John B Holcomb, Jan Jansen
INTRODUCTION: The Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial failed to demonstrate a mortality difference for hemorrhaging patients receiving a balanced (1:1:1) vs a 1:1:2 resuscitation at 24 hours and 30 days. Recent guidelines recommend earlier mortality end points for hemorrhage-control trials, and the use of contemporary statistical methods. The aim of this post hoc analysis of the PROPPR trial was to evaluate the impact of a balanced resuscitation strategy at early resuscitation time points using a Bayesian analytical framework...
2023: Trauma Surgery & Acute Care Open
https://read.qxmd.com/read/37558046/the-effect-of-thrombocytapheresis-on-hemogram-and-biochemistry-parameters-in-patients-with-essential-thrombocytemia
#32
JOURNAL ARTICLE
Ahmet Kaya, İrfan Kuku, Mehmet Ali Erkurt, Emin Kaya, İlhami Berber, Soykan Biçim, Emine Hidayet, Salih Cırık, Süleyman Arslan, Fatma Hilal Yağin, Ahmet Sarıcı
BACKGROUND: Essential thrombocythemia is one of the chronic myeloproliferative neoplasms characterized by clonal proliferation of myeloid cells with variable morphological maturation and hematopoietic activity.It is characterized by excessive clonal platelet production with a tendency to thrombosis and bleeding. Thrombocytapheresıs is the removal of platelets by apheresis techniques. Thrombocytapheresıs is generally recommended in patients with essential thrombocythemia with acute, severe thrombotic or hemorrhagic events...
August 7, 2023: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://read.qxmd.com/read/37536432/open-conversion-with-explantation-of-stent-grafts-after-endovascular-aneurysm-repair-for-abdominal-aortic-aneurysm
#33
JOURNAL ARTICLE
Katsuhiro Yamanaka, Ryo Kawabata, Mari Hamaguchi, Shunya Chomei, Taishi Inoue, Shota Hasegawa, Takanori Tsujimoto, Yojiro Koda, Shunsuke Miyahara, Hiroaki Takahashi, Takuya Okada, Masato Yamaguchi, Kenji Okada
BACKGROUND: Although endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) is widely used worldwide, the fact that it is associated with increased rates of reintervention has been considered a problem. This study aimed to analyze the outcomes of primary open AAA repair and open conversion with explantation of stent grafts after EVAR. METHODS: In this retrospective study, we enrolled 1,120 patients (open repair, n = 664; EVAR, n = 456) who underwent AAA repair at Kobe University from 1999 to 2019...
August 2, 2023: Annals of Vascular Surgery
https://read.qxmd.com/read/37492322/blood-product-transfusion-practices-in-pediatric-critically-ill-patients-at-a-tertiary-care-hospital-pakistan
#34
JOURNAL ARTICLE
Muhammad Rafique, Sharmeen Nasir, Amber Kamran, Ammarah Jamal
OBJECTIVE: To determine the frequency of inappropriate blood product transfusions in pediatric critically ill patients. METHODS: We collected data for this descriptive study from January to December 2020 at the Pediatric Intensive Care Unit (PICU) of Dr. RKMP Civil Hospital, Karachi. We included all patients one month to 12 years of age, admitted to pediatric intensive care unit and received any blood product transfusion. We reviewed their medical records and noted the demographic and clinical variables, type of blood product transfused with its indication and determined whether transfusion was appropriate or not, as per the standard guidelines and consensus recommendations...
2023: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/37452616/platelet-transfusions-and-predictors-of-bleeding-in-patients-with-myelodysplastic-syndromes
#35
JOURNAL ARTICLE
Allison Mo, Erica Wood, Jake Shortt, Erin Hu, Zoe McQuilten
OBJECTIVES: This study aimed to describe the burden of thrombocytopenia, supportive care practices, bleeding complications and predictors of bleeding in MDS patients within a large Australian hospital network, to better understand the use and effectiveness of platelet transfusions in MDS. METHODS: A retrospective cohort study of patients aged ≥18 years with MDS, chronic myelomonocytic leukaemia or MDS/myeloproliferative overlap neoplasm admitted from 2016 to 2018 was conducted...
July 15, 2023: European Journal of Haematology
https://read.qxmd.com/read/37341019/pediatric-moderate-and-severe-traumatic-brain-injury-a-systematic-review-of-clinical-practice-guideline-recommendations
#36
REVIEW
Anis Ben Abdeljelil, Gabrielle C Freire, Natalie Yanchar, Alexis F Turgeon, Suzanne Beno, Melanie Bérubé, Antonia Stang, Thomas Stelfox, Roger Zemek, Emilie Beaulieu, Isabelle J Gagnon, Belinda Gabbe, Francois Lauzier, Melanie Labrosse, Pier-Alexandre Tardif, Theony Deshommes, Janyce Gnanvi, Lynne Moore
Traumatic brain injury (TBI) is the leading cause of death and disability in children. Many clinical practice guidelines (CPGs) have addressed pediatric TBI in the last decade but significant variability in the use of these guidelines persists. Here, we systematically review CPGs recommendations for pediatric moderate-to-severe TBI, evaluate the quality of CPGs, synthesize the quality of evidence and strength of included recommendations, and identify knowledge gaps. A systematic search was conducted in MEDLINE® , Embase, Cochrane CENTRAL, Web of Science, and Web sites of organizations publishing recommendations on pediatric injury care...
November 2023: Journal of Neurotrauma
https://read.qxmd.com/read/37269022/circuit-change-during-extracorporeal-membrane-oxygenation-single-center-retrospective-study-of-48-changes
#37
JOURNAL ARTICLE
Thibaut Genty, Stanislas Burguburu, Audrey Imbert, Calypso Roman, Wirth Camille, Jacques Thès, François Stéphan
BACKGROUND: Bleeding and thrombosis induce major morbidity and mortality in patients under extracorporeal membrane oxygenator (ECMO). Circuit changes can be performed for oxygenation membrane thrombosis but are not recommended for bleeding under ECMO. The objective of this study was to evaluate the course of clinical, laboratory, and transfusion parameters before and after ECMO circuit changes warranted by bleeding or thrombosis. METHODS: In this single-center, retrospective, cohort study, clinical parameters (bleeding syndrome, hemostatic procedures, oxygenation parameters, transfusion) and laboratory parameters (platelet count, hemoglobin, fibrinogen, PaO2 ) were collected over the seven days surrounding the circuit change...
June 2, 2023: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/37224197/platelet-transfusion-before-cvc-placement-in-patients-with-thrombocytopenia
#38
RANDOMIZED CONTROLLED TRIAL
Floor L F van Baarle, Emma K van de Weerdt, Walter J F M van der Velden, Roelof A Ruiterkamp, Pieter R Tuinman, Paula F Ypma, Walter M van den Bergh, Astrid M P Demandt, Emile D Kerver, A J Gerard Jansen, Peter E Westerweel, Sesmu M Arbous, Rogier M Determann, Walther N K A van Mook, Mirelle Koeman, Anja B U Mäkelburg, Krijn P van Lienden, Jan M Binnekade, Bart J Biemond, Alexander P J Vlaar
BACKGROUND: Transfusion guidelines regarding platelet-count thresholds before the placement of a central venous catheter (CVC) offer conflicting recommendations because of a lack of good-quality evidence. The routine use of ultrasound guidance has decreased CVC-related bleeding complications. METHODS: In a multicenter, randomized, controlled, noninferiority trial, we randomly assigned patients with severe thrombocytopenia (platelet count, 10,000 to 50,000 per cubic millimeter) who were being treated on the hematology ward or in the intensive care unit to receive either one unit of prophylactic platelet transfusion or no platelet transfusion before ultrasound-guided CVC placement...
May 25, 2023: New England Journal of Medicine
https://read.qxmd.com/read/37166405/in-vitro-quality-of-cold-and-delayed-cold-stored-platelet-concentrates-from-interim-platelet-units-during-storage-for-21%C3%A2-days
#39
JOURNAL ARTICLE
Hanne Braathen, Turid Helen Felli Lunde, Jörg Assmus, Kristin Gjerde Hagen, Einar Klaeboe Kristoffersen, Geir Strandenes, Torunn Oveland Apelseth
BACKGROUND AND OBJECTIVES: Based on previous success using apheresis platelets, we wanted to investigate the in vitro quality and platelet function in continuously cold-stored and delayed cold-stored platelet concentrates (PCs) from interim platelet units (IPUs) produced by the Reveos system. MATERIALS AND METHODS: We used a pool-and-split design to prepare 18 identical pairs of PCs. One unit was stored unagitated and refrigerated after production on day 1 (cold-stored)...
May 11, 2023: Vox Sanguinis
https://read.qxmd.com/read/37155364/postoperative-transfusions-after-administration-of-delayed-cold-stored-platelets-versus-room-temperature-platelets-in-cardiac-surgery-a-retrospective-cohort-study
#40
JOURNAL ARTICLE
Allan M Klompas, Simon Zec, Andrew C Hanson, Tim Weister, James Stubbs, Daryl J Kor, Matthew A Warner
BACKGROUND: Delayed cold storage of room temperature platelets may extend shelf life from 5 to 14 days. The study hypothesized that the use of delayed cold-stored platelets in cardiac surgery would be associated with decreased postoperative platelet count increments but similar transfusion and clinical outcomes compared to room temperature-stored platelets. METHODS: This is an observational cohort study of adults transfused with platelets intraoperatively during elective cardiac surgery between April 2020 and May 2021...
August 1, 2023: Anesthesiology
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