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https://www.readbyqxmd.com/read/29341330/real-time-and-high-resolution-bioimaging-with-bright-aggregation-induced-emission-dots-in-short-wave-infrared-region
#1
Ji Qi, Chaowei Sun, Abudureheman Zebibula, Hequn Zhang, Ryan T K Kwok, Xinyuan Zhao, Wang Xi, Jacky W Y Lam, Jun Qian, Ben Zhong Tang
Fluorescence imaging in the spectral region beyond the conventional near-infrared biological window (700-900 nm) can theoretically afford high resolution and deep tissue penetration. Although some efforts have been devoted to developing a short-wave infrared (SWIR; 900-1700 nm) imaging modality in the past decade, long-wavelength biomedical imaging is still suboptimal owing to the unsatisfactory materials properties of SWIR fluorophores. Taking advantage of organic dots based on an aggregation-induced emission luminogen (AIEgen), herein microscopic vasculature imaging of brain and tumor is reported in living mice in the SWIR spectral region...
January 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29340649/optic-nerve-regeneration-after-crush-remodels-the-injury-site-molecular-insights-from-imaging-mass-spectrometry
#2
David T Stark, David M G Anderson, Jacky M K Kwong, Nathan Heath Patterson, Kevin L Schey, Richard M Caprioli, Joseph Caprioli
Purpose: Mammalian central nervous system axons fail to regenerate after injury. Contributing factors include limited intrinsic growth capacity and an inhibitory glial environment. Inflammation-induced optic nerve regeneration (IIR) is thought to boost retinal ganglion cell (RGC) intrinsic growth capacity through progrowth gene expression, but effects on the inhibitory glial environment of the optic nerve are unexplored. To investigate progrowth molecular changes associated with reactive gliosis during IIR, we developed an imaging mass spectrometry (IMS)-based approach that identifies discriminant molecular signals in and around optic nerve crush (ONC) sites...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29339936/satellite-stories-capturing-professional-experiences-of-academic-health-sciences-librarians-working-in-delocalized-health-sciences-programs
#3
Jackie Phinney, Amanda Rose Horsman
Objective: Health sciences training programs have progressively expanded onto satellite campuses, allowing students the opportunity to learn in communities away from an academic institution's main campus. This expansion has encouraged a new role for librarians to assume, in that a subset of health sciences librarians identify as "satellite librarians" who are permanently located at a distance from the main campus. Due to the unique nature of this role and lack of existing data on the topic, the authors investigated the experiences and perceptions of this unique group of information professionals...
January 2018: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/29339814/long-lived-hot-carrier-light-emission-and-large-blue-shift-in-formamidinium-tin-triiodide-perovskites
#4
Hong-Hua Fang, Sampson Adjokatse, Shuyan Shao, Jacky Even, Maria Antonietta Loi
A long-lived hot carrier population is critical in order to develop working hot carrier photovoltaic devices with efficiencies exceeding the Shockley-Queisser limit. Here, we report photoluminescence from hot-carriers with unexpectedly long lifetime (a few ns) in formamidinium tin triiodide. An unusual large blue shift of the time-integrated photoluminescence with increasing excitation power (150 meV at 24 K and 75 meV at 293 K) is displayed. On the basis of the analysis of energy-resolved and time-resolved photoluminescence, we posit that these phenomena are associated with slow hot carrier relaxation and state-filling of band edge states...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29336222/implementing-a-health-home-michigan-s-experience
#5
Jackie Prokop, Marie LaPres, Brad Barron, Jon Villasurda
As the number of individuals in the United States with chronic conditions and the associated costs in caring for these individuals continues to rise, there is a need to transform how health care services are delivered. Under Section 2703 of the Affordable Care Act of 2010, the federal government provides state Medicaid programs the opportunity to improve care coordination for people with chronic conditions in a person-centered approach through the establishment of health homes. Given the complexity of care for Medicaid beneficiaries with chronic conditions, addressing the social determinants of health and providing integrated care are central to effectively improving health outcomes and generating cost-savings...
January 1, 2018: Policy, Politics & Nursing Practice
https://www.readbyqxmd.com/read/29334373/prevention-of-tuberculosis-in-rhesus-macaques-by-a-cytomegalovirus-based-vaccine
#6
Scott G Hansen, Daniel E Zak, Guangwu Xu, Julia C Ford, Emily E Marshall, Daniel Malouli, Roxanne M Gilbride, Colette M Hughes, Abigail B Ventura, Emily Ainslie, Kurt T Randall, Andrea N Selseth, Parker Rundstrom, Lauren Herlache, Matthew S Lewis, Haesun Park, Shannon L Planer, John M Turner, Miranda Fischer, Christina Armstrong, Robert C Zweig, Joseph Valvo, Jackie M Braun, Smitha Shankar, Lenette Lu, Andrew W Sylwester, Alfred W Legasse, Martin Messerle, Michael A Jarvis, Lynn M Amon, Alan Aderem, Galit Alter, Dominick J Laddy, Michele Stone, Aurelio Bonavia, Thomas G Evans, Michael K Axthelm, Klaus Früh, Paul T Edlefsen, Louis J Picker
Despite widespread use of the bacille Calmette-Guérin (BCG) vaccine, tuberculosis (TB) remains a leading cause of global mortality from a single infectious agent (Mycobacterium tuberculosis or Mtb). Here, over two independent Mtb challenge studies, we demonstrate that subcutaneous vaccination of rhesus macaques (RMs) with rhesus cytomegalovirus vectors encoding Mtb antigen inserts (hereafter referred to as RhCMV/TB)-which elicit and maintain highly effector-differentiated, circulating and tissue-resident Mtb-specific CD4+ and CD8+ memory T cell responses-can reduce the overall (pulmonary and extrapulmonary) extent of Mtb infection and disease by 68%, as compared to that in unvaccinated controls, after intrabronchial challenge with the Erdman strain of Mtb at ∼1 year after the first vaccination...
January 15, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29334229/physical-and-psychological-health-of-carers-of-young-people-with-first-episode-psychosis
#7
Abner Weng Cheong Poon, Jackie Curtis, Philip Ward, Celia Loneragan, Julia Lappin
OBJECTIVE: Carers of people with psychosis may experience psychological distress and caregiving burden. However, few studies have examined both psychological and physical health of carers of young people with first episode psychosis (FEP). METHOD: A total of 32 young people with FEP and 42 of their carers were recruited from a mental health service. Standardised scales were administered to assess carers' psychological distress and risk for development of Type 2 diabetes...
January 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29332386/multiple-yet-controllable-photoswitching-in-a-single-aiegen-system
#8
Peifa Wei, Jing-Xuan Zhang, Zheng Zhao, Yuncong Chen, Xuewen He, Ming Chen, Junyi Gong, Herman H-Y Sung, Ian D Williams, Jacky W Y Lam, Ben Zhong Tang
Seeking new methods to obtain elaborate artificial on-demand photoswitching with multiple functionalities remains challenging. Most of the systems reported so far possess only one specific function and their non-emissive nature in the aggregated state inevitably limit their applications. Herein, a tailored cyanostilbene-based molecule with aggregation-induced emission characteristic was synthesized and was found to exhibit efficient, multiple and controllable photoswitching behaviors under different conditions...
January 14, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29331743/preliminary-investigation-of-human-exhaled-breath-for-tuberculosis-diagnosis-by-multidimensional-gas-chromatography-time-of-flight-mass-spectrometry-and-machine-learning
#9
Marco Beccaria, Theodore R Mellors, Jacky S Petion, Christiaan A Rees, Mavra Nasir, Hannah K Systrom, Jean W Sairistil, Marc-Antoine Jean-Juste, Vanessa Rivera, Kerline Lavoile, Patrice Severe, Jean W Pape, Peter F Wright, Jane E Hill
Tuberculosis (TB) remains a global public health malady that claims almost 1.8 million lives annually. Diagnosis of TB represents perhaps one of the most challenging aspects of tuberculosis control. Gold standards for diagnosis of active TB (culture and nucleic acid amplification) are sputum-dependent, however, in up to a third of TB cases, an adequate biological sputum sample is not readily available. The analysis of exhaled breath, as an alternative to sputum-dependent tests, has the potential to provide a simple, fast, and non-invasive, and ready-available diagnostic service that could positively change TB detection...
January 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29331463/discriminating-aging-and-protein-to-fat-ratio-in-cheddar-cheese-using-sensory-analysis-and-a-potentiometric-electronic-tongue
#10
Jackie B Lipkowitz, Carolyn F Ross, Charles Diako, Denise M Smith
The objectives of this study were to evaluate the flavor and taste attributes of full-fat Cheddar cheeses with different protein-to-fat ratios (PFR) over aging time using a descriptive sensory analysis panel and a consumer panel, and to correlate these attributes with instrumental parameters obtained by the potentiometric electronic tongue. Three Cheddar cheese formulations (PFR of 0.74, 0.85, and 1.01) were produced in triplicate and composition was verified. Cheese was aged at 7.2°C and evaluated at 2, 5, 8, 10, 11, and 12 mo by a trained panel (n = 10) for 8 flavor and 5 taste attributes and using an electronic tongue for 7 nonvolatile taste attributes...
January 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29329925/phenotypic-and-molecular-characterisation-of-a-serum-free-miniature-erythroid-differentiation-system-suitable-for-high-throughput-screening-and-single-cell-assays
#11
Sachith Mettananda, Kevin Clark, Chris A Fisher, Jackie A Sloane-Stanley, Richard J Gibbons, Douglas R Higgs
In vitro erythroid differentiation systems are used to study the mechanisms underlying normal and abnormal erythropoiesis and to test the effects of various extracellular factors on erythropoiesis. The use of serum or conditioned medium in liquid cultures, and seeding cultures with heterogeneous peripheral blood mononuclear cells confound the reproducibility of these systems. Newer erythroid differentiation culture systems have overcome some of these limitations by using a fully defined, serum-free, medium and initiating cultures using purified CD34+ cells...
January 9, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29327409/cultural-aspects-of-pain-a-study-of-indian-asian-women-in-the-uk
#12
Stephanie Holt, Jackie Waterfield
OBJECTIVES: Culture and ethnicity are acknowledged as important factors in the context of the biopsychosocial model. They may contribute to explaining the experience of pain, therapeutic encounters within healthcare, and the strategies that individuals use to cope with pain. The present study explored these issues in a sample of Indian Asian women in the UK. METHODS: Based on a phenomenological approach, 17 women participated in five semi-structured group interviews...
January 12, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29326537/total-ossicular-replacement-prosthesis-a-new-fat-interposition-technique
#13
Issam Saliba, Valérie Sabbah, Jackie Bibeau Poirier
Objective: To compare audiometric results between the standard total ossicular replacement prosthesis (TORP-S) and a new fat interposition total ossicular replacement prosthesis (TORP-F) in pediatric and adult patients and to assess the complication and the undesirable outcome. Study design: This is a retrospective study. Methods: This study included 104 patients who had undergone titanium implants with TORP-F and 54 patients who had undergone the procedure with TORP-S between 2008 and 2013 in our tertiary care centers...
2018: Clinical Medicine Insights. Ear, Nose and Throat
https://www.readbyqxmd.com/read/29326199/genome-sequences-of-four-cluster-p-mycobacteriophages
#14
Erin L Doyle, Christy L Fillman, Nathan S Reyna, Deborah M Tobiason, Daniel E Westholm, Jonathan L Askins, Brittany P Backus, Ashlynn C Baker, Harrison S Ballard, Paul J Bisesi, Logan Bond, Deanna Byrnes, Hannah Carlstedt, Kinnon S Dodson, Megan J Fallert, Kyla J Foster, Daniel N Games, Tristan R Grams, Nancy A Guild, Autumn Hurd, Nicholas Iwata, Cassidy R Kepler, Lucinda R Krenzke, Kelly Luekens, Jackie Lewis, Cali McEntee, Justin C McGee, Noah Nalley, Ruth C Plymale, Jade Prochaska, Reid G Rogers, Jessica B Schipper, Kelsey Snyder, Kali Uhrich, Chelsey D Vermillion, Sarah K Vickers, Meredyth D Wenta, Tyler Z Yates, Chas F Young, Ty H Stoner, Welkin H Pope, Deborah Jacobs-Sera, Rebecca A Garlena, Daniel A Russell, Steven G Cresawn, Graham F Hatfull
Four bacteriophages infecting Mycobacterium smegmatis mc2155 (three belonging to subcluster P1 and one belonging to subcluster P2) were isolated from soil and sequenced. All four phages are similar in the left arm of their genomes, but the P2 phage differs in the right arm. All four genomes contain features of temperate phages.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29325117/blood-rna-signatures-prospectively-discriminate-controllers-from-progressors-early-after-low-dose-m-tuberculosis-infection-of-cynomolgus-macaques
#15
Ethan G Thompson, Smitha Shankar, Hannah P Gideon, Jackie Braun, Joe Valvo, Jason Skinner, Alan Aderem, JoAnne L Flynn, Philana Ling Lin, Daniel E Zak
The cynomolgus macaque model of low-dose Mycobacterium tuberculosis (Mtb) infection recapitulates clinical aspects of human TB pathology but it is unknown whether the two systems are sufficiently similar that host-based signatures of TB will be predictive across species. By blind prediction, we demonstrate that a subset of genes comprising a human signature for TB risk is simultaneously predictive in humans and macaques and prospectively discriminates progressor from controller animals 3-6 weeks after infection...
January 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29321557/haptic-shape-discrimination-and-interhemispheric-communication
#16
Catherine J Dowell, J Farley Norman, Jackie R Moment, Lindsey M Shain, Hideko F Norman, Flip Phillips, Astrid M L Kappers
In three experiments participants haptically discriminated object shape using unimanual (single hand explored two objects) and bimanual exploration (both hands were used, but each hand, left or right, explored a separate object). Such haptic exploration (one versus two hands) requires somatosensory processing in either only one or both cerebral hemispheres; previous studies related to the perception of shape/curvature found superior performance for unimanual exploration, indicating that shape comparison is more effective when only one hemisphere is utilized...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315591/suppression-of-a-single-bahd-gene-in-setaria-viridis-causes-large-stable-decreases-in-cell-wall-feruloylation-and-increases-biomass-digestibility
#17
Wagner R de Souza, Polyana K Martins, Jackie Freeman, Till K Pellny, Louise V Michaelson, Bruno L Sampaio, Felipe Vinecky, Ana P Ribeiro, Barbara A D B da Cunha, Adilson K Kobayashi, Patricia A de Oliveira, Raquel B Campanha, Thályta F Pacheco, Danielly C I Martarello, Rogério Marchiosi, Osvaldo Ferrarese-Filho, Wanderley D Dos Santos, Robson Tramontina, Fabio M Squina, Danilo C Centeno, Marília Gaspar, Marcia R Braga, Marco A S Tiné, John Ralph, Rowan A C Mitchell, Hugo B C Molinari
Feruloylation of arabinoxylan (AX) in grass cell walls is a key determinant of recalcitrance to enzyme attack, making it a target for improvement of grass crops, and of interest in grass evolution. Definitive evidence on the genes responsible is lacking so we studied a candidate gene that we identified within the BAHD acyl-CoA transferase family. We used RNA interference (RNAi) silencing of orthologs in the model grasses Setaria viridis (SvBAHD01) and Brachypodium distachyon (BdBAHD01) and determined effects on AX feruloylation...
January 8, 2018: New Phytologist
https://www.readbyqxmd.com/read/29314326/stable-light-emitting-diodes-using-phase-pure-ruddlesden-popper-layered-perovskites
#18
Hsinhan Tsai, Wanyi Nie, Jean-Christophe Blancon, Constantinos C Stoumpos, Chan Myae Myae Soe, Jinkyoung Yoo, Jared Crochet, Sergei Tretiak, Jacky Even, Aditya Sadhanala, Giovanni Azzellino, Roberto Brenes, Pulickel M Ajayan, Vladimir Bulović, Samuel D Stranks, Richard H Friend, Mercouri G Kanatzidis, Aditya D Mohite
State-of-the-art light-emitting diodes (LEDs) are made from high-purity alloys of III-V semiconductors, but high fabrication cost has limited their widespread use for large area solid-state lighting. Here, efficient and stable LEDs processed from solution with tunable color enabled by using phase-pure 2D Ruddlesden-Popper (RP) halide perovskites with a formula (CH3 (CH2 )3 NH3 )2 (CH3 NH3 )n-1 Pbn I3n+1 are reported. By using vertically oriented thin films that facilitate efficient charge injection and transport, efficient electroluminescence with a radiance of 35 W Sr-1 cm-2 at 744 nm with an ultralow turn-on voltage of 1 V is obtained...
January 3, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29305339/digital-clinical-communication-for-families-and-caregivers-of-children-or-young-people-with-short-or-long-term-conditions-rapid-review
#19
REVIEW
Xavier Armoiry, Jackie Sturt, Emma Elizabeth Phelps, Clare-Louise Walker, Rachel Court, Frances Taggart, Paul Sutcliffe, Frances Griffiths, Helen Atherton
BACKGROUND: The communication relationship between parents of children or young people with health conditions and health professionals is an important part of treatment, but it is unclear how far the use of digital clinical communication tools may affect this relationship. OBJECTIVE: The objective of our study was to describe, assess the feasibility of, and explore the impact of digital clinical communication between families or caregivers and health professionals...
January 5, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29304943/using-a-discrete-choice-experiment-involving-cost-to-value-a-classification-system-measuring-the-quality-of-life-impact-of-self-management-for-diabetes
#20
Donna Rowen, Katherine Stevens, Alexander Labeit, Jackie Elliott, Brendan Mulhern, Jill Carlton, Hasan Basarir, Julie Ratcliffe, John Brazier
OBJECTIVES: To describe the use of a novel approach in health valuation of a discrete-choice experiment (DCE) including a cost attribute to value a recently developed classification system for measuring the quality-of-life impact (both health and treatment experience) of self-management for diabetes. METHODS: A large online survey was conducted using DCE with cost on UK respondents from the general population (n = 1497) and individuals with diabetes (n = 405). The data were modeled using a conditional logit model with robust standard errors...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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