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https://www.readbyqxmd.com/read/28230253/risk-of-vigabatrin-associated-brain-abnormalities-on-mri-in-the-treatment-of-infantile-spasms-is-dose-dependent
#1
Shaun A Hussain, Jackie Tsao, Menglu Li, Madeline D Schwarz, Raymond Zhou, Joyce Y Wu, Noriko Salamon, Raman Sankar
OBJECTIVE: Although the link between vigabatrin (VGB) and retinotoxicity is well known, little attention has been focused on the risk of VGB-associated brain abnormalities on magnetic resonance imaging (MRI) (VABAM), namely reversible-and largely asymptomatic-signal changes in the thalami, basal ganglia, brainstem tegmentum, and cerebellar nuclei. Using a large infantile spasms cohort, we set out to identify predictors of these phenomena. METHODS: Children with infantile spasms were retrospectively identified...
February 23, 2017: Epilepsia
https://www.readbyqxmd.com/read/28228937/predictors-of-total-morbidity-burden-on-days-3-5-and-8-after-cardiac-surgery
#2
Julie Sanders, Jackie Cooper, Michael G Mythen, Hugh E Montgomery
BACKGROUND: Post-operative morbidity affects up to 36% of cardiac surgical patients. However, few countries reliably record morbidity outcome data, despite patients wanting to be informed of all the risks associated with surgery. The Cardiac Post-Operative Morbidity Score (C-POMS) is a new tool for describing and scoring (0-13) total morbidity burden after cardiac surgery, derived by noting the presence/absence of 13 morbidity domains on days 3, 5, 8 and 15. Identifying modifiable C-POMS risk factors may suggest targets for intervention to reduce morbidity and healthcare costs...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/28219974/the-availability-of-smoking-permitted-accommodations-from-airbnb-in-12-canadian-cities
#3
Ryan David Kennedy, Ornell Douglas, Lindsay Stehouwer, Jackie Dawson
PURPOSE: Airbnb is a web-based peer-to-peer (P2P) service that enables potential hosts and guests to broker accommodations in private homes as an alternative to traditional hotels. The hospitality sector has increasingly gone smoke-free over the last decade. This study identified the availability and cost of smoking-permitted accommodations identified on Airbnb. METHODS: The study team searched for Airbnb accommodations in 12 Canadian cities across each of Canada's 10 provinces...
February 20, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28218750/quaternary-contact-in-the-initial-interaction-of-cd4-with-the-hiv-1-envelope-trimer
#4
Qingbo Liu, Priyamvada Acharya, Michael A Dolan, Peng Zhang, Christina Guzzo, Jacky Lu, Alice Kwon, Deepali Gururani, Huiyi Miao, Tatsiana Bylund, Gwo-Yu Chuang, Aliaksandr Druz, Tongqing Zhou, William J Rice, Christoph Wigge, Bridget Carragher, Clinton S Potter, Peter D Kwong, Paolo Lusso
Binding of the gp120 envelope (Env) glycoprotein to the CD4 receptor is the first step in the HIV-1 infectious cycle. Although the CD4-binding site has been extensively characterized, the initial receptor interaction has been difficult to study because of major CD4-induced structural rearrangements. Here we used cryogenic electron microscopy (cryo-EM) to visualize the initial contact of CD4 with the HIV-1 Env trimer at 6.8-Å resolution. A single CD4 molecule is embraced by a quaternary HIV-1-Env surface formed by coalescence of the previously defined CD4-contact region with a second CD4-binding site (CD4-BS2) in the inner domain of a neighboring gp120 protomer...
February 20, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28213575/planning-workforce-requirements-for-genitourinary-medicine
#5
Jackie Sherrard, Angela Robinson
No abstract text is available yet for this article.
March 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28213574/highlights-from-this-issue
#6
EDITORIAL
Jackie A Cassell
No abstract text is available yet for this article.
March 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28212912/pulmonary-embolism-in-the-postanesthesia-care-unit-a-case-study
#7
Debbie Smith, Jackie Murauski
Pulmonary embolism (PE) is a complication that can occur at any time during the perioperative period. The patient undergoing surgery to repair a hip fracture is at a high risk of developing a PE due to venous thrombosis, tissue, or fat emboli. The signs and symptoms of a PE are often nonspecific and can be obscured in the patient receiving or recovering from general anesthesia. This case study describes the presentation, diagnosis, and treatment of a patient experiencing a pulmonary embolism in the postanesthesia care unit (PACU) after surgery to repair a hip fracture...
February 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/28198938/left-atrial-deformation-analysis-in-patients-with-corrected-tetralogy-of-fallot-by-3d-speckle-tracking-echocardiography-from-the-magyar-path-study
#8
Kálmán Havasi, Péter Domsik, Anita Kalapos, Jackie S McGhie, Jolien W Roos-Hesselink, Tamás Forster, Attila Nemes
Background: Three-dimensional (3D) echocardiography coupled with speckle-tracking echocardiographic (STE) capability is a novel methodology which has been demontrated to be useful for the assessment of left atrial (LA) volumes and functional properties. There is increased scientific interest on myocardial deformation analysis in adult patients with corrected tetralogy of Fallot (cTOF). Objectives: To compare LA volumes, volume-based functional properties and strain parameters between cTOF patients and age- and gender-matched healthy controls...
February 13, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28197657/gestational-diabetes-and-adverse-perinatal-outcomes-from-716-152-births-in-france-in-2012
#9
Cécile Billionnet, Delphine Mitanchez, Alain Weill, Jacky Nizard, François Alla, Agnès Hartemann, Sophie Jacqueminet
AIMS/HYPOTHESIS: The aim of this study was to assess the risk of adverse perinatal outcomes in gestational diabetes mellitus (GDM) in a large national cohort. METHODS: All deliveries taking place after 22 weeks in France in 2012 were included by extracting data from the hospital discharge database and the national health insurance system. The diabetic status of mothers was determined by the use of glucose-lowering agents and by hospital diagnosis. Outcomes were analysed according to the type of diabetes and, in the GDM group, whether or not diabetes was insulin-treated...
February 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28195448/mitochondrion-anchoring-photosensitizer-with-aggregation-induced-emission-characteristics-synergistically-boosts-the-radiosensitivity-of-cancer-cells-to-ionizing-radiation
#10
Chris Y Y Yu, Huae Xu, Shenglu Ji, Ryan T K Kwok, Jacky W Y Lam, Xiaolin Li, Sunil Krishnan, Dan Ding, Ben Zhong Tang
The first mitochondrion-anchoring photosensitizer that specifically generates singlet oxygen ((1) O2 ) in mitochondria under white light irradiation that can serve as a highly effective radiosensitizer is reported here, significantly sensitizing cancer cells to ionizing radiation. An aggregation-induced emission luminogen (AIEgen), namely DPA-SCP, is rationally designed with α-cyanostilbene as a simple building block to reveal AIE, diphenylamino (DPA) group as a strong electron donating group to benefit red emission and efficient light-controlled (1) O2 generation, as well as a pyridinium salt as the targeting moiety to ensure specific mitochondrial localization...
February 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28193912/the-effects-of-graded-levels-of-calorie-restriction-viii-impact-of-short-term-calorie-and-protein-restriction-on-basal-metabolic-rate-in-the-c57bl-6-mouse
#11
Sharon E Mitchell, ZhanHui Tang, Celine Kerbois, Camille Delville, Davina Derous, Cara L Green, Yingchun Wang, Jackie J D Han, Luonan Chen, Alex Douglas, David Lusseau, Daniel E L Promislow, John R Speakman
Under calorie restriction (CR) animals need to lower energy demands. Whether this involves a reduction in cellular metabolism is an issue of contention. We exposed C57BL/6 mice to graded CR for 3 months, measured BMR and dissected out 20 body compartments. From a separate age-matched group (n=57), we built 7 predictive models for BMR. Unadjusted BMR declined with severity of restriction. Comparison of measured and predicted BMR from the simple models suggested suppression occurred. The extent of 'suppression' was greater with increased CR severity...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28193618/incorporating-cancer-risk-information-into-general-practice-a-qualitative-study-using-focus-groups-with-health-professionals
#12
Juliet A Usher-Smith, Barbora Silarova, Alison Ward, Jane Youell, Kenneth R Muir, Jackie Campbell, Joanne Warcaba
BACKGROUND: It is estimated that approximately 40% of all cases of cancer are attributable to lifestyle factors. Providing people with personalised information about their future risk of cancer may help promote behaviour change. AIM: To explore the views of health professionals on incorporating personalised cancer risk information, based on lifestyle factors, into general practice. DESIGN AND SETTING: Qualitative study using data from six focus groups with a total of 24 general practice health professionals from the NHS Nene Clinical Commissioning Group in England...
February 13, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28192044/an-early-look-at-the-association-between-state-medicaid-expansion-and-disparities-in-cardiovascular-diseases-a-comprehensive-population-health-management-approach
#13
Christopher K Rogers, Ning Jackie Zhang
Cardiovascular disease (CVD) is one of the most prevalent chronic diseases nationally and disproportionately affects low-income individuals. There are substantial disparities on CVD outcomes that stem from the lack of health insurance among low-income populations. The Affordable Care Act expands Medicaid health insurance to low-income populations, and aims to increase the utilization of health, social, and economic preventive services to reduce health disparities and prevent chronic diseases. The authors analyzed data from the 2014 Behavioral Risk Factor Surveillance System to understand the potential impact of Medicaid expansion on disparities in CVD among low-income populations...
February 13, 2017: Population Health Management
https://www.readbyqxmd.com/read/28188222/characterization-of-genomic-deletion-efficiency-mediated-by-clustered-regularly-interspaced-short-palindromic-repeats-crispr-cas9-nuclease-system-in-mammalian-cells
#14
Matthew C Canver, Daniel E Bauer, Abhishek Dass, Yvette Y Yien, Jacky Chung, Takeshi Masuda, Takahiro Maeda, Barry H Paw, Stuart H Orkin
No abstract text is available yet for this article.
February 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28176572/extreme-care-on-aids-wards
#15
Jackie Hunt
I was completely absorbed in your feature 'Nursing in a war zone' (1 February). As a night sister at the Middlesex Hospital in the 1980s, aged 25, I looked after patients with AIDS, without any training or warning of what I might encounter. I just found them shut away in side rooms.
February 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28173843/staff-experiences-of-closing-out-a-clinical-trial-involving-withdrawal-of-treatment-qualitative-study
#16
Julia Lawton, David White, David Rankin, Jackie Elliott, Carolin Taylor, Cindy Cooper, Simon Heller, Nina Hallowell
BACKGROUND: The ending of a clinical trial may be challenging, particularly if staff are required to withdraw the investigated treatment(s); however, this aspect of trial work is surprisingly under-researched. To address this gap, we explored the experiences of staff involved in closing out a trial that entailed withdrawal of treatment (insulin pumps) from some patients. METHODS: Interviews were conducted with n = 22 staff, recruited from seven trial sites. Data were analysed thematically...
February 7, 2017: Trials
https://www.readbyqxmd.com/read/28173151/exclusive-expression-of-mecp2-in-the-nervous-system-distinguishes-between-brain-and-peripheral-rett-syndrome-like-phenotypes
#17
Paul D Ross, Jacky Guy, Jim Selfridge, Bushra Kamal, Noha Bahey, K Elizabeth Tanner, Thomas H Gillingwater, Ross A Jones, Christopher M Loughrey, Charlotte S McCarroll, Mark E S Bailey, Adrian Bird, Stuart Cobb
No abstract text is available yet for this article.
October 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28169521/biased-signaling-by-peptide-agonists-of-protease-activated-receptor-2
#18
Yuhong Jiang, Mei-Kwan Yau, W Mei Kok, Junxian Lim, Kai-Chen Wu, Ligong Liu, Timothy A Hill, Jacky Y Suen, David P Fairlie
Protease activated receptor 2 (PAR2) is associated with metabolism, obesity, inflammatory, respiratory and gastrointestinal disorders, pain, cancer and other diseases. The extracellular N-terminus of PAR2 is a common target for multiple proteases, which cleave it at different sites to generate different N-termini that activate different PAR2-mediated intracellular signaling pathways. There are no synthetic PAR2 ligands that reproduce the same signaling profiles and potencies as proteases. Structure-activity relationships here for 26 compounds spanned a signaling bias over 3 log units, culminating in three small ligands as biased agonist tools for interrogating PAR2 functions...
February 7, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28168977/diffuse-coronary-artery-disease-among-other-atherosclerotic-plaque-characteristics-by-coronary-computed-tomography-angiography-for-predicting-coronary-vessel-specific-ischemia-by-fractional-flow-reserve
#19
Asim Rizvi, Bríain Ó Hartaigh, Ibrahim Danad, Donghee Han, Ji Hyun Lee, Heidi Gransar, Jackie Szymonifka, Fay Y Lin, James K Min
BACKGROUND AND AIMS: Coronary computed tomography angiography (CCTA) permits effective identification of diffuse CAD and atherosclerotic plaque characteristics (APCs). We sought to examine the usefulness of diffuse CAD beyond luminal narrowing and APCs by CCTA to detect vessel-specific ischemia. METHODS: 407 vessels (n = 252 patients) from the DeFACTO diagnostic accuracy study were retrospectively analyzed for percent plaque diffuseness (PD). Percent plaque diffuseness (PD) was obtained on per-vessel level by summation of all contiguous lesion lengths and divided by total vessel length, and was logarithmically transformed (log percent PD)...
January 16, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28167353/genetic-risk-analysis-of-coronary-artery-disease-in-pakistani-subjects-using-a-genetic-risk-score-of-21-variants
#20
Saleem Ullah Shahid, Shabana, Jackie A Cooper, Katherine E Beaney, Kawah Li, Abdul Rehman, Steve E Humphries
BACKGROUND AND AIMS: Conventional coronary artery disease (CAD) risk factors like age, gender, blood lipids, hypertension and smoking have been the basis of CAD risk prediction algorithms, but provide only modest discrimination. Genetic risk score (GRS) may provide improved discrimination over and above conventional risk factors. Here we analyzed the genetic risk of CAD in subjects from Pakistan, using a GRS of 21 variants in 18 genes and examined whether the GRS is associated with blood lipid levels...
January 22, 2017: Atherosclerosis
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