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https://www.readbyqxmd.com/read/25765519/a-systematic-review-of-dydrogesterone-for-the-treatment-of-recurrent-miscarriage
#1
REVIEW
Howard Carp
The objective of this systematic review was to assesses whether the orally acting progestagen, dydrogesterone lowers the incidence of subsequent miscarriage in women with recurrent miscarriage. A computerized search was performed in Medline, Embase and Ovid Medline for original reports with the product name "Duphaston" or "dydrogesterone" and limited to clinical human data. Thirteen reports of dydrogesterone treatment were identified. Two randomized trials and one non-randomized comparative trial were identified, including 509 women who fulfilled the criteria for meta-analysis...
June 2015: Gynecological Endocrinology
https://www.readbyqxmd.com/read/25622239/oral-dydrogesterone-versus-vaginal-progesterone-gel-in-the-luteal-phase-support-randomized-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Vlatka Tomic, Jozo Tomic, Djurdja Zigmundovac Klaic, Miro Kasum, Krunoslav Kuna
OBJECTIVES: To compare efficacy, satisfaction and tolerability of oral dydrogesterone and micronized vaginal progesterone gel used for luteal supplementation. STUDY DESIGN: Randomized controlled trial. A total of 853 infertile women undergoing IVF/ICSI treatment in University Hospital Center "Sisters of Mercy", Zagreb, Croatia. Luteal support was provided as Crinone 8%(®) vaginal progesterone gel (90mg) administered daily, or oral dydrogesterone Duphaston(®) (2× 10mg) administered two times daily...
March 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/22794306/a-systematic-review-of-dydrogesterone-for-the-treatment-of-threatened-miscarriage
#3
REVIEW
Howard Carp
The objective of this systematic review was to assess whether the orally acting progestagen, dydrogesterone lowers the incidence of miscarriage in women with threatened miscarriage. A computerized search was performed in Medline, Embase, and Ovid Medline for original reports with the product name 'Duphaston' or 'dydrogesterone', and limited to clinical human data. Twenty-one reports of dydrogesterone treatment were identified with 1380 patients. Five randomized trials were identified, including 660 women who fulfilled the criteria for meta-analysis...
December 2012: Gynecological Endocrinology
https://www.readbyqxmd.com/read/16369056/-combined-usage-of-duphaston-and-reaferon-for-infertility-treatment-in-patients-with-endometriosis
#4
L T Koridze, M A Dzhangidze
A new method of treatment of endometriosis includes combination of surgical and hormonal therapy. Surgical method included excision of tissue with endometriosis, while the hormonal therapy involved the combination of dufaston and reaferon-EC (recombinant interferon alpha 2b). The aim of this study was to develop effective method of treatment of infertility caused by endometriosis using combination of dufaston and reaferon. There were 114 patients under observation who suffered from endometriosis and infertility...
November 2005: Georgian Medical News
https://www.readbyqxmd.com/read/15515816/effect-of-hormonal-replacement-therapy-on-autonomic-regulation-of-the-heart
#5
Tomasz Banach, Lukasz Dobrek, Tomasz Milewicz, Władysława Kolasińska-Kloch, Józef Krzysiek, Piotr J Thor
BACKGROUND: Increased incidence of cardiovascular diseases frequently reported in postmenopausal women may follow disturbed activity of cardiac autonomic nervous system (cANS). Our purpose was to evaluate the influence of continuous combined hormonal replacement therapy (ccHRT) on cANS reflected by parameters of heart rate variability (HRV). METHOD: Thirty four healthy postmenopausal women aged 56+/-6 years (7+/-4 years after last menorrhoea) were divided into 2 equal groups--women receiving ccHRT (serum estradiol--81+/-75 ng/l, FSH--45+/-27 IU/l) and control group (serum estradiol--31+/-45 ng/l, FSH--74+/-32 IU/l)...
2004: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/15274306/dydrogesterone-duphaston-and-its-20-dihydro-derivative-as-selective-estrogen-enzyme-modulators-in-human-breast-cancer-cell-lines-effect-on-sulfatase-and-on-17beta-hydroxysteroid-dehydrogenase-17beta-hsd-activity
#6
Gérard Samuel Chetrite, Hubert H Thole, Jean-Claude Philippe, Jorge Raul Pasqualini
Estradiol (E2) is one of the main factors which control the growth and evolution of breast cancer. Consequently, to block the formation of E2 inside cancer cells has been an important target in recent years. Breast cancer cells possess all the enzymatic systems (e.g. sulfatase, aromatase, 17beta-hydroxysteroid dehydrogenase [17beta-HSD]) involved in the conversion of estrogen precursors into E2. Sulfotransferase, which converts estrogen to its sulfate, is also present in this tumoral tissue. Duphaston is a synthetic progestogen with properties similar to the natural progesterone...
May 2004: Anticancer Research
https://www.readbyqxmd.com/read/14577368/-efficacy-of-duphaston-treatment-in-women-with-endometriosis-after-reconstructive-surgery
#7
G M Makhmudova, D K Nazhmutdinova, D Kh Gafarova, Iu D Lukmanova
The authors present outcomes of inspection of 300 women suffering from genital endometriosis. Localization and thermocoagulation of endometriosis was performed by diagnostic and operative laparoscopy. After operation women were treated with hormonomodulative therapy. Patients were divided in five groups, depending on prescribed treatment. The authors concluded that the most effective is therapy with progestine dydrogesterone (Duphaston). For comparison there are presented groups of patients without hormonal treatment after operation...
2003: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/14273095/duphaston-in-dysmenorrhoea-the-results-of-a-double-blind-clinical-trial
#8
D V FAIRWEATHER
No abstract text is available yet for this article.
April 1965: Journal of Obstetrics and Gynaecology of the British Commonwealth
https://www.readbyqxmd.com/read/14215356/6-dehydro-retroprogesterone-duphaston-an-interesting-progesterone-like-compound
#9
C K AYDAR, R B GREENBLATT
No abstract text is available yet for this article.
October 1964: International Journal of Fertility
https://www.readbyqxmd.com/read/13863774/isopregnenone-duphaston-a-new-progestational-agent
#10
M H BACKER
No abstract text is available yet for this article.
June 1962: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/12590270/luteal-phase-support-in-ovarian-induction-cycles-using-human-chorionic-gonadotropin-or-oral-progestagens
#11
COMPARATIVE STUDY
Faheem F Zayed, Mohammad F El-Jallad, Haifa A Al-Chalabi
OBJECTIVE: To determine the efficacy of luteal phase support with human chorionic gonadotropin (hCG) or oral progesterone during human menopausal gonadotropin (hMG) ovulation induction. METHODS: Between September 1999 and March 2001, a total of 91 couples with infertility were recruited at Al-Hammadi Hospital, Riyadh, Kingdom of Saudi Arabia and Badeea Hospital, Jordan. In this prospective trial 46 couples were allocated to luteal phase support with hCG injections, while 45 couples were allocated to Duphaston (oral progestogens) as luteal support...
January 2003: Saudi Medical Journal
https://www.readbyqxmd.com/read/11915585/effect-of-hormone-replacement-therapy-on-insulin-secretion-and-insulin-sensitivity-in-postmenopausal-diabetic-women
#12
A M Borissova, T Tankova, P Kamenova, L Dakovska, R Kovacheva, G Kirilov, N Genov, B Milcheva, D Koev
The aim of the present study was to evaluate the effect of three different combinations of hormone replacement therapy (HRT) on insulin secretion, peripheral insulin sensitivity, serum lipid levels and parameters of oxidative stress. Seven type II diabetic women of mean age 55.4 +/- 4.7 years, who had been menopausal for an average of 5 years, were enrolled in the study. Phases of insulin secretion--first (FPIS) and second (SPIS)--and the area under the curve (AUC) for insulin secretion were studied during an intravenous glucose tolerance test (IVGTT)...
February 2002: Gynecological Endocrinology
https://www.readbyqxmd.com/read/11559992/-treatment-of-endometriosis-in-female-infertility
#13
K P Tumasian, V V Bespoiasnaia, I V Voronovskaia
A total of 16 women with endometriosis 25 to 36 years old were examined. Of these, 6 presented with primary infertility, 10--with secondary intertility, 7 female patients had endometriosis concurrent with other localizations. The treatment was with duphaston (dydrogesteron), 10 mg (5 mg twice a day) beginning from day 5 till 25 of the menstrual cycle for 6 months. The control echography and hysteroscopy permitted ascertaining regression of endometrioid foci in 13 female patients. According to the histological findings in 15 women the endometrium corresponded to the proliferative phase of the menstrual cycle, with its focal hyperplasia having been noted in 1 woman...
May 2001: Likars'ka Sprava
https://www.readbyqxmd.com/read/11082907/-dydrogesterone-duphaston-in-the-prevention-of-risk-of-ultrasound-guided-amniocentesis
#14
J Korczyński
Oral administration of 20 mg per day Dydrogesterone was recommended in 28 pregnancies as a prevention of risks due to ultrasound guided amniocentesis. Reduction rate (3.6% vs. 5.0%) of uterine cramping and/or uterine contraction wave, observed in US were noticed comparing to the control (n = 40). No spontaneous abortion was noticed in both groups during two weeks follow up. Amniotic fluid leakage was noticed in 2.5% of control comparing to none in the Dydrogesterone group.
August 2000: Ginekologia Polska
https://www.readbyqxmd.com/read/7926076/a-randomized-double-blind-placebo-controlled-study-of-luteal-phase-dydrogesterone-duphaston-in-women-with-minimal-to-mild-endometriosis
#15
RANDOMIZED CONTROLLED TRIAL
C E Overton, P C Lindsay, B Johal, S A Collins, N C Siddle, R W Shaw, D H Barlow
OBJECTIVE: To compare dydrogesterone with placebos in the treatment of minimal to mild endometriosis. DESIGN: Prospective, double-blind, randomized study. SETTING: Three Obstetrics and Gynaecology Departments in the United Kingdom. PATIENTS: Sixty-two premenopausal women with complaints of pain (n = 12) and infertility with or without pain (n = 50) with minimal to mild endometriosis diagnosed at laparoscopy. Thirty-nine women had a laparoscopy after treatment and 56 women were followed up 12 months after treatment...
October 1994: Fertility and Sterility
https://www.readbyqxmd.com/read/7923797/low-dose-estrogen-replacement-therapy-in-early-postmenopausal-women-effect-on-urinary-magnesium-and-calcium-creatinine-ratios
#16
B Kaplan, A Neri, E Kitai, Y Pardo, M Blum, J Friedman
The purpose of this study was to investigate whether treatment for prevention of osteoporosis by means of postmenopausal hormone replacement therapy (HRP) and daily exercise, had any effect on ratios of urinary calcium:creatinine (Ca:Cre) and magnesium:creatinine (Mg:Cre). A group of 33 early postmenopausal women (menopause onset 12-18 months previously), mean age 49.12 years, were treated during 6 months with low doses of transdermal estrogen (Estraderm TTS 25 micrograms, Ciba-Geigy) opposed by oral progestogen (Duphaston 10 mg, 10 days every month), and daily exercise (walking for 1 hour)...
1994: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/7189174/-treatment-of-the-premenstrual-syndrome-with-a-retroprogesterone-duphaston
#17
J R Strecker
The symptomatology of the premenstrual syndrome is frequently seen in general and gynecological practice. The aim of this study was to examine the therapeutical effect of dydrogesterone (Duphaston) on the typical premenstrual complaints as depression, headache, edema, mastodynia, dysmenorrhea and bleeding irregularities. Oral administration of 20 mg dydrogesterone b.i.d. during the second half of the menstrual cycle could well relieve the complaints mentioned above. Best results of treatment were obtained in cases of dysmenorrhea, bleeding irregularities, depression and edema...
January 31, 1980: Fortschritte der Medizin
https://www.readbyqxmd.com/read/6925397/-duphaston
#18
P Lange, C Gervais
No abstract text is available yet for this article.
October 1982: Soins. Gynécologie, Obstétrique, Puériculture, Pédiatrie
https://www.readbyqxmd.com/read/6724478/-mechanism-of-action-of-dydrogesterone-in-dysmehorrhea-prostaglandin-levels-in-menstrual-blood
#19
H P Zahradnik
Menstrual blood was collected from seven dysmenorrhoeic volunteers age 20-35, during nine cycles. After three control-cycles the women were treated with dydrogesteron ( Duphaston ) 2 X 10 mg/die, day 5-25, for a period of six months. Blood loss was constant over the study period. Estradiol excretion was significantly reduced during dydrogesteron treatment, whereas oestron excretion remained unchanged. Progesteron excretion was significantly higher during the treatment period (2p less than or equal to 0,05)...
April 19, 1984: Fortschritte der Medizin
https://www.readbyqxmd.com/read/6144593/hormones-and-electrolytes-in-premenstrual-syndrome
#20
T R Varma
We studied 10 normal and asymptomatic patients with ovulatory cycles and measured serum sodium, potassium, FSH, LH, prolactin, estradiol, progesterone and cortisol. The findings were compared with the levels in 25 patients with ovulatory cycles with premenstrual symptoms (PMS) lasting for 7-14 days prior to the onset of menstrual flow. We found no significant difference in serum sodium and potassium levels between the asymptomatic (control) group and the PMS group, or between the follicular and luteal phases of the menstrual cycle...
February 1984: International Journal of Gynaecology and Obstetrics
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