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https://www.readbyqxmd.com/read/29784463/anti-m%C3%A3-llerian-hormone-profiling-in-prepubertal-horses-and-its-relationship-with-gonadal-function
#1
Dragos Scarlet, Manuela Wulf, Juliane Kuhl, Martin Köhne, Natascha Ille, Alan J Conley, Christine Aurich
Anti-Müllerian hormone (AMH) has gained increasing interest as a biomarker for assessment of gonadal activity. The ability to predict the ovarian follicular reserve of prepubertal female horses (fillies) or to identify stallions with testicular pathologies already during their prepubertal life has not been analyzed so far. Both would help to select fertile horses and reduce costs associated with keeping animals. The objectives of the present study were to (1) assess AMH, LH, FSH, progesterone (females) and testosterone (males) dynamics in prepubertal horses from birth onwards and (2) determine whether AMH concentrations detected in plasma of prepubertal female and male horses are correlated with postpubertal gonadal development...
May 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29781510/tramadol-opioid-abuse-is-associated-with-a-dose-and-time-dependent-poor-sperm-quality-and-hyperprolactinaemia-in-young-men
#2
A G A Farag, M A Basha, S A Amin, N F Elnaidany, N G Elhelbawy, M M T Mostafa, S A Khodier, R A Ibrahem, R Z Mahfouz
Tramadol, one of the most commonly abused drugs in Middle East, impacts spermatogenesis and disturbs reproductive hormones in animal studies. We aimed to investigate tramadol impact on sperm quality and on levels of testosterone, prolactin and gonadotropins, in tramadol abusers (n = 30) to age-matched control (n = 30). Abusers had significantly low percentages of sperm motility, normal forms and vitality compared with control (95% CI -40.7 to -19.3, -13.5 to -9.3 and -31.9 to -9.7 respectively). Hypoandrogenism (95% CI -4...
May 21, 2018: Andrologia
https://www.readbyqxmd.com/read/29757049/prevalence-of-indicators-of-low-energy-availability-in-elite-female-sprinters
#3
Jennifer Sygo, Alexandra M Coates, Erik Sesbreno, Margo L Mountjoy, Jamie F Burr
Low energy availability (LEA), and subsequent relative energy deficiency in sport (RED-S), has been observed in endurance, aesthetic, and team sport athletes, with limited data on prevalence in athletes in short-burst activities such as sprinting. We examined prevalence of signs and symptoms of LEA in elite female sprinters at the start of the training season (PRE), and at the end of a 5-month indoor training period (POST). Four of 13 female sprinters (31%) presented at PRE testing with at least one primary (amenorrhea, low BMD, low FSH, LH, or estradiol, RMR ≤ 29kcal/kg FFM, Low Energy Availability in Females Questionnaire (LEAF-Q) score ≥8) and one secondary indicator of LEA (fasting blood glucose < 4mmol/L, free triiodothyronine < 3...
May 14, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29738165/-correlation-of-serum-zinc-alpha-2-glycoprotein-with-blood-lipid-and-reproductive-hormone-levels-in-men
#4
Chao-Ju Yang, Rui-Yu Han, Shu-Song Wang
Objective: To study the changes of the serum zinc alpha 2 glycoprotein (ZAG) level in men and its relationship with blood lipid male reproductive hormones. METHODS: We enrolled 297 men aged 25- 65 years in this study, 152 with hyperlipemia (HL) and the other 145 with normal blood lipid (normal control). We divided them into four age groups (25-35 yr, 36-45 yr, 46-55 yr, and 56-65 yr) and three tertile groups (Q1, Q2, and Q3) according to the tertiles of the serum ZAG level, and examined their blood lipid, blood glucose, serum ZAG, and reproductive hormones...
November 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29731240/predicting-live-birth-for-poor-ovarian-responders-the-prosper-concept
#5
Philippe Lehert, Wai Chin, Joan Schertz, Thomas D'Hooghe, Carlo Alviggi, Peter Humaidan
RESEARCH QUESTION: A number of live-birth predictive models are available, and despite clinical interest these are rarely used owing to poor performance. In addition, no predictive models specifically for poor ovarian responders (POR) are available. The aim of the current project was to develop a clinically applicable tool for predicting live birth for PORs receiving recombinant human FSH [r-hFSH]. DESIGN: A model was developed to predict live birth in PORs receiving r-hFSH, using data from the ESPART trial...
March 29, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29722946/-correlation-of-serum-anti-m%C3%A3-llerian-hormone-with-semen-parameters
#6
Long-Ping Peng, Yong Shao, Cen-Cen Wang, Zhi-Chuan Zou, Tao Shen, Li Chen, Bing Yao
Objective: To investigate the relationship between the serum anti-Müllerian hormone (AMH) level and semen parameters. METHODS: We collected the data about 726 outpatients at the Male Infertility Clinic of Jinling Hospital from September 2015 to November 2016, including 72 with non-obstructive azoospermia, 123 with oligospermia, and 531 with normal sperm concentration. We obtained the semen volume, total sperm count, sperm concentration, sperm motility, the percentages of progressively motile sperm (PMS) and morphologically normal sperm (MNS), and the levels of serum AMH, inhibin B (INH-B), total testosterone (TT) and follicle - stimulating hormone (FSH) of the patients, analyzed the correlation of the serum AMH level with the other parameters, and compared the AMH level among different groups...
June 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29721915/clinical-biochemical-and-molecular-overview-of-transaldolase-deficiency-and-evaluation-of-the-endocrine-function-update-of-34-patients
#7
M Williams, V Valayannopoulos, R Altassan, W K Chung, A C Heijboer, W T Keng, R Lapatto, P McClean, M F Mulder, A Tylki-Szymańska, M J E Walenkamp, M Alfadhel, H Alakeel, G S Salomons, W Eyaid, M M C Wamelink
BACKGROUND: Transaldolase deficiency (TALDO-D) is a rare autosomal recessive inborn error of the pentose phosphate pathway. Since its first description in 2001, several case reports have been published, but there has been no comprehensive overview of phenotype, genotype, and phenotype-genotype correlation. METHODS: We performed a retrospective questionnaire and literature study of clinical, biochemical, and molecular data of 34 patients from 25 families with proven TALDO-D...
May 2, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29704382/establishing-the-cut-off-values-of-androgen-markers-in-the-assessment-of-polycystic-ovarian-syndrome
#8
R N D Nadaraja, P Sthaneshwar, N Razali
INTRODUCTION: Hyperandrogenism remains as one of the key features in Polycystic Ovarian Syndrome (PCOS) and can be assessed clinically or determined by biochemical assays. Hirsutism is the most common clinical manifestation of hyperandrogenism. The clinical assessment is subjected to wide variability due to poor interobserver agreement and multiple population factors such as ethnic variation, cosmetic procedures and genetic trait. The difficulty in resolving the androgen excess biochemically is due to a lack of consensus as to which serum androgen should be measured for the diagnosis of PCOS...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29694329/correlation-of-platelet-to-lymphocyte-and-neutrophil-to-lymphocyte-ratio-with-hormonal-and-metabolic-parameters-in-women-with-pcos
#9
Vasilios Pergialiotis, Eftihios Trakakis, Christos Parthenis, Erifili Hatziagelaki, Charalampos Chrelias, Nikolaos Thomakos, Nikolaos Papantoniou
Background The purpose of our study is to evaluate the association of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) with hormonal and metabolic parameters in patients with polycystic ovarian syndrome (PCOS) in order to assess whether these ratios may become useful tools during the evaluation of the severity of low grade inflammation. Methods The present study is based in secondary outcomes from a prospectively collected patient database. A total of 266 women with PCOS participated in this study and blood a complete blood count examination (CBC) that was used for the calculation of PLR and NLR was available in 182 patients...
April 25, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29688494/discordance-between-serum-anti-m%C3%A3-llerian-hormone-concentrations-and-antral-follicle-counts-not-only-technical-issues
#10
M Š Alebic, N Stojanovic, D Dewailly
STUDY QUESTION: Do patient-specific features contribute to the differences between measured serum anti-Müllerian hormone (AMH) concentrations and AMH values expected from the corresponding antral follicle count (AFC)? SUMMARY ANSWER: Patient-specific features contribute to the differences between measured AMH values and AMH values expected from the corresponding AFC (AMHp), potentially through their effect on follicular AMH production. WHAT IS KNOWN ALREADY: Both patient counselling and patient management could be hampered by finding of disagreement between AFC and AMH if both are used for the prediction of ovarian response...
April 24, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29661134/transcriptome-analysis-of-granulosa-cells-after-conventional-vs-long-fsh-induced-superstimulation-in-cattle
#11
F C F Dias, M I R Khan, M A Sirard, G P Adams, J Singh
BACKGROUND: Prolongation of superstimulatory treatment appears to be associated with a greater superovulatory response and with greater oocyte maturation in cattle. A genome-wide bovine oligo-microarray was used to compare the gene expression of granulosa cells collected from ovarian follicles after differing durations of the growing phase induced by exogenous FSH treatment. Cows were given a conventional (4-day) or long (7-day) superstimulatory treatment (25 mg FSH im at 12-h intervals; n = 6 per group), followed by prostaglandin treatment with last FSH and LH treatment 24 h later...
April 16, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29659847/follicle-growth-and-endocrine-dynamics-in-women-with-spontaneous-luteinized-unruptured-follicles-versus-ovulation
#12
S T Bashir, A R Baerwald, M O Gastal, R A Pierson, E L Gastal
STUDY QUESTION: Do growth patterns and endocrine profiles differ between ovulatory follicles (OvFs) and luteinized unruptured follicles (LUFs) in women? SUMMARY ANSWER: Growth rates, diameters and associated endocrine profiles differed between OvFs and LUFs in unstimulated cycles. WHAT IS KNOWN ALREADY: Two-three waves of antral follicles develop during the menstrual cycle in ovulatory women of reproductive age, with the second or third wave terminating in ovulation...
April 6, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29652213/ovarian-reserve-in-young-juvenile-idiopathic-arthritis-patients
#13
Gabriela R V Ferreira, Renato B Tomioka, Nadia E Aikawa, Elaine P Leon, Gustavo A R Maciel, Paulo C Serafini, Edmund C Baracat, Claudia Goldenstein-Schainberg, Rosa M R Pereira, Eloisa Bonfá, Clovis A Silva
OBJECTIVES: Juvenile idiopathic arthritis (JIA) occurs during reproductive age, however, there are not systematic data regarding ovarian function in this disease. METHODS: Twenty-eight post-pubertal JIA patients and age-matched 28 healthy controls were studied. Complete ovarian function was assessed during the early follicular phase of the menstrual cycle including anti-Müllerian hormone (AMH), estradiol, luteinizing hormone (LH), follicle stimulating hormone (FSH) and antral follicle count (AFC) by ovarian ultrasound, and anti-corpus lutheum antibodies (anti-CoL)...
April 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29650233/bisphenol-a-exposure-and-risk-of-idiopathic-central-precocious-puberty-among-school-aged-girls-in-shanghai-china
#14
Yao Chen, Yingcan Wang, Guodong Ding, Ying Tian, Zhijun Zhou, Xiumin Wang, Lixiao Shen, Hong Huang
BACKGROUND: Bisphenol A (BPA) is a well-known and widely used endocrine disrupter, but data on its effects on childhood reproductive development are limited. OBJECTIVES: We investigated the possible relationship between exposure to BPA and idiopathic central precocious puberty (ICPP) in school-aged girls. METHODS: We conducted a 1:1 matched case-control study in Shanghai, China, between July 2011 and September 2012. This study included 136 school-aged (6 to 9 years old) girls diagnosed with ICPP and 136 controls matched for age and body mass index (BMI)...
April 9, 2018: Environment International
https://www.readbyqxmd.com/read/29617818/fshb-211-g-t-is-a-major-genetic-modulator-of-reproductive-physiology-and-health-in-childbearing-age-women
#15
Kristiina Rull, Marina Grigorova, Aivar Ehrenberg, Pille Vaas, Aire Sekavin, Diana Nõmmemees, Mart Adler, Ele Hanson, Peeter Juhanson, Maris Laan
STUDY QUESTION: Are the genetic variants FSHB -211 G>T (rs10835638), FSHR c.2039 A>G (Asn680Ser, rs6166) and FSHR -29 G>A (rs1394205) associated with serum FSH, LH and anti-Müllerian hormone (AMH) levels in reproductive age women, their menstrual cycle parameters and risk of infertility? SUMMARY ANSWER: Only the FSHB -211 G>T variant was a major genetic determinant of serum gonadotropin levels in both, eumenorrheic healthy women and female infertility patients, and the T-allele carrier status was enriched among idiopathic infertility cases...
March 30, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29615476/neuronostatin-exerts-actions-on-pituitary-that-are-unique-from-its-sibling-peptide-somatostatin
#16
Raul M Luque, Rhonda D Kineman
Neuronostatin, a somatostatin gene-encoded peptide, exerts important physiological and metabolic actions in diverse tissues. However, the direct biological effects of neuronostatin on pituitary function of humans and primates are still unknown. This study used baboon (Papio anubis) primary pituitary cell cultures, a species that closely models human physiology, to demonstrate that neuronostatin inhibits basal, but not ghrelin-/GnRH-stimulated, GH and LH secretion in a dose- and time-dependent fashion, without affecting the secretion of other pituitary hormones (prolactin, ACTH, FSH, TSH) or changing mRNA levels...
April 3, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29610059/gonadotropin-concentrations-associated-with-variations-in-diameter-deviation-during-follicle-selection-in-holstein-heifers
#17
O J Ginther, R R Domingues, S V Dangudubiyyam, E R Araujo
Diameter deviation or selection of the future dominant follicle (F1) from the future largest subordinate follicle (F2) during a follicular wave occurs when F1 is 8.5 mm (expected deviation, day 0). Deviation has been classified as conventional (F2 ≥ 7.0 mm), F2-undersized (F2 < 7.0 mm), and F1,F2-switched (F2 larger than F1 on day -1 or 0). Concentrations of gonadotropins were compared within and among deviation classifications in waves 1 and 2 in 48 heifers. A three-way (wave 1 compared with 2, classification, day) analysis indicated no effect of wave 1 compared with 2 on F2 or FSH...
March 26, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29604127/interactions-between-different-media-and-follicle-stimulating-hormone-supplementation-on-in-vitro-culture-of-preantral-follicles-enclosed-in-ovarian-tissue-derived-from-collared-peccaries-pecari-tajacu-linneaus-1758
#18
G L Lima, V B Luz, L F Lima, Rmp Rocha, S V Castro, T S Castelo, Apr Rodrigues, J R Figueiredo, A R Silva
The aim was to verify the effect of follicle-stimulating hormone (FSH) supplementation to α-MEM+ or TCM199+ media on the in vitro development of ovarian preantral follicles (PFs) derived from collared peccaries. Ovaries (n = 5 pairs) were collected and divided into fragments destined to control group (non-cultured) or treatments that were cultured for 7 days. The PFs morphology, growth and activation were evaluated by classical histology. The immunohistochemistry markers Ag-NOR and PCNA were used for nuclear proliferation analysis, and the picrosirius red labelling was used for ovarian extracellular matrix (ECM) evaluation...
March 31, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29583035/a-long-term-follow-up-study-of-men-born-with-very-low-birth-weight-and-their-reproductive-hormone-profile
#19
Mats Hammar, Erika Larsson, Marie Bladh, Orvar Finnström, P O Gäddlin, Ingemar Leijon, Elvar Theodorsson, Gunilla Sydsjö
Environmental factors during the fetal period may adversely affect reproductive functions in men being born with very low birth weight (VLBW, <1500 g). The objective of this prospective, controlled cohort study was to investigate if VLBW men have an altered reproductive hormone profile compared with men born at term. The study group initially consisted of all VLBW boys live-born between 1 February 1987 and 30 April 1988 in the south-east region of Sweden (n = 47). A control child was chosen born at term, at the same hospital, with the same parity, without malformations, and next in order after each VLBW child who survived the first four weeks (n = 45)...
March 27, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29546532/adiposity-results-in-metabolic-and-inflammation-differences-in-premenopausal-and-postmenopausal-women-consistent-with-the-difference-in-breast-cancer-risk
#20
H Zhao, J Wang, D Fang, O Lee, R T Chatterton, V Stearns, S A Khan, S E Bulun
Obesity is associated with increased risk of breast cancer in postmenopausal but not in premenopausal women. Many factors may be responsible for this difference. The aim of this study was to determine the mechanisms by which the genes related to the AMPK pathway, inflammation, and estrogen actions are affected by adiposity in breast tissue with the objective of identifying differences that may explain the different breast cancer risk in premenopausal and postmenopausal women. Random fine needle aspirates (rFNAs) of breast tissue were collected from 57 premenopausal and 55 postmenopausal women and were classified as normal weight, overweight, or obese...
March 15, 2018: Hormones & Cancer
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