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https://www.readbyqxmd.com/read/28938749/the-testicular-transcriptome-associated-with-spermatogonia-differentiation-initiated-by-gonadotrophin-stimulation-in-the-juvenile-rhesus-monkey-macaca-mulatta
#1
Suresh Ramaswamy, William H Walker, Paula Aliberti, Rahil Sethi, Gary R Marshall, Alyxzandria Smith, Seyedmehdi Nourashrafeddin, Alicia Belgorosky, Uma R Chandran, Mark P Hedger, Tony M Plant
STUDY QUESTION: What is the genetic landscape within the testis of the juvenile rhesus monkey (Macaca mulatta) that underlies the decision of undifferentiated spermatogonia to commit to a pathway of differentiation when puberty is induced prematurely by exogenous LH and FSH stimulation? SUMMARY ANSWER: Forty-eight hours of gonadotrophin stimulation of the juvenile monkey testis resulted in the appearance of differentiating B spermatogonia and the emergence of 1362 up-regulated and 225 down-regulated testicular mRNAs encoding a complex network of proteins ranging from enzymes regulating Leydig cell steroidogenesis to membrane receptors, and from juxtacrine and paracrine factors to transcriptional factors governing spermatogonial stem cell fate...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938419/nocturnal-urinary-excretion-of-fsh-and-lh-in-children-and-adolescents-with-normal-and-early-puberty
#2
Nanna Kolby, Alexander S Busch, Lise Aksglaede, Kaspar Sørensen, Jorgen Holm Petersen, Anna-Maria Andersson, Anders Juul
Context: Clinical use of single serum gonadotropin measurements in children is limited by the pulsatile section of FSH and LH. However, first morning voided (FMV) urine may integrate the fluctuating gonadotropin serum levels. Objective: We aimed to evaluate urinary and serum gonadotropin levels according to age, sex and pubertal stage in healthy children and to assess the clinical use of FMV urinary gonadotropins in children with disordered puberty. Design: Cross-sectional part of the COPENHAGEN Puberty study and longitudinal study of patients...
August 15, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28933574/is-there-a-role-for-kisspeptin-in-pathogenesis-of-polycystic-ovary-syndrome
#3
Umit Gorkem, Cihan Togrul, Emine Arslan, Ayla Sargin Oruc, Nuriye Buyukkayaci Duman
AIM: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. MATERIALS AND METHODS: In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist/hip ratio (WHR) were measured...
September 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28926843/the-genetic-basis-of-delayed-puberty
#4
S R Howard, Leo Dunkel
<br>The genetic control of puberty remains an important but mostly unanswered question. Late pubertal timing affects over 2% of adolescents and is associated with adverse health outcomes including short stature, reduced bone mineral density and compromised psychosocial health. Self-limited delayed puberty (DP) is a highly heritable trait, which often segregates in an autosomal dominant pattern; however, its neuroendocrine pathophysiology and genetic regulation remain unclear. Some insights into the genetic mutations that lead to familial DP have come from sequencing genes known to cause GnRH deficiency, most recently via next generation sequencing, and others from large-scale genome wide association studies in the general population...
September 18, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28923176/gaps-limitations-and-new-insights-on-endogenous-estrogen-and-follicle-stimulating-hormone-as-related-to-risk-of-cardiovascular-disease-in-women-traversing-the-menopause-a-narrative-review
#5
REVIEW
Samar R El Khoudary
While it is known that estrogen protects heart health in women prior to menopause, its role after menopause and during the menopause transition is far less apparent. Previous reviews summarizing the literature on the impact of endogenous estrogen on risk of cardiovascular disease (CVD) have focused on postmenopausal women and have not come to a clear conclusion. No previous review has summarized the associations between follicle stimulating hormone (FSH), a proxy measure of the menopause transition, and CVD risk...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28881231/follicles-and-gonadotropins-during-waves-2-and-3-in-three-wave-interovulatory-intervals-in-bos-taurus-heifers
#6
O J Ginther, M A R Siddiqui, E R Araujo, S V Dangudubiyyam
Observations were made on follicle dynamics and gonadotropin concentrations in anovulatory wave 2 and ovulatory wave 3 in three-wave interovulatory intervals (n = 15). Hypotheses were not used owing to inadequate availability of rationale. The future dominant follicles for waves 2 and 3 were designated DF2 and DF3 and the largest future subordinate follicles as SF2 and SF3, respectively. The day of expected diameter deviation (day 0) was defined as the day that DF2 or DF3 was closest to 8.5 mm. The first day that DF2 became smaller (P < 0...
August 30, 2017: Theriogenology
https://www.readbyqxmd.com/read/28880909/in-vivo-biological-activity-and-glycosylation-analysis-of-a-biosimilar-recombinant-human-follicle-stimulating-hormone-product-bemfola-compared-with-its-reference-medicinal-product-gonal-f
#7
Renato Mastrangeli, Abhijeet Satwekar, Francesca Cutillo, Cinzia Ciampolillo, Wolf Palinsky, Salvatore Longobardi
Recombinant human follicle-stimulating hormone (r-hFSH) is widely used in fertility treatment. Although biosimilar versions of r-hFSH (follitropin alfa) are currently on the market, given their structural complexity and manufacturing process, it is important to thoroughly evaluate them in comparison with the reference product. This evaluation should focus on how they differ (e.g., active component molecular characteristics, impurities and potency), as this could be associated with clinical outcome. This study compared the site-specific glycosylation profile and batch-to-batch variability of the in-vivo bioactivity of Bemfola, a biosimilar follitropin alfa, with its reference medicinal product GONAL-f...
2017: PloS One
https://www.readbyqxmd.com/read/28871409/retrospective-analysis-of-treatments-with-recombinant-fsh-and-recombinant-lh-versus-human-menopausal-gonadotropin-in-women-with-reduced-ovarian-reserve
#8
Mario Mignini Renzini, Claudio Brigante, Giovanni Coticchio, Mariabeatrice Dal Canto, Ilaria Caliari, Ruggero Comi, Elena De Ponti, Rubens Fadini
PURPOSES: The aim of this study is to determine whether a clinical advantage is gained with use of LH in combination with FSH or as a component of human menopausal gonadotropin (hMG) to achieve optimal ovarian stimulation. METHODS: In this study, we compared retrospectively two regimens, r-FSH/r-LH and hMG, for the treatment of women with reduced ovarian reserve, identified as subjects with antral follicle count (AFC) < 11 and AMH ≤ 1.1 ng/ml. RESULTS: Overall, the clinical pregnancy per started cycle was higher in the r-FSH/r-LH group (12...
September 4, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28859283/plasma-anti-m%C3%A3-llerian-hormone-profile-in-heifers-from-birth-through-puberty-and-relationship-with-puberty-onset
#9
Hossam El-Sheikh Ali, Go Kitahara, Toru Takahashi, Shogo Mido, Mohammed Sadawy, Ikuo Kobayashi, Koichiro Hemmi, Takeshi Osawa
The current study aimed to define the plasma profile of anti-Müllerian hormone (AMH) and follicle stimulating hormone (FSH) in heifers during postnatal life until achieving puberty, as defined by plasma progesterone (P4) profile, to demonstrate a relationship between AMH and age of puberty onset. Blood samples collected from 11 Japanese Black female calves within 1 week after birth (W 0) and then biweekly until the sixth week after puberty (WP 6) were assayed for AMH, FSH, and P4. The heifers were classified into two groups based on age of puberty onset: ≤42 weeks (early puberty group; EP, n = 4) and ≥44 weeks (late puberty group; LP, n = 7)...
July 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28852860/bilateral-endoscopic-totally-extraperitoneal-tep-inguinal-hernia-repair-does-not-impair-male-fertility
#10
M M Roos, G J Clevers, E J Verleisdonk, P H Davids, C van de Water, R J Spermon, L S Mulder, J P J Burgmans
PURPOSE: Endoscopic totally extraperitoneal (TEP) hernia repair with polypropylene mesh has become a well-established technique. However, since the mesh is placed in close contact with the spermatic cord, mesh-induced inflammation may affect its structures, possibly resulting in impaired fertility. The aim of this observational prospective cohort study was to assess fertility after bilateral endoscopic TEP inguinal hernia repair in male patients. METHODS: Fifty-seven male patients (22-60 years old) with primary, reducible, bilateral inguinal hernias underwent elective bilateral endoscopic TEP hernia repair with use of polypropylene mesh...
August 29, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28831696/brca1-mutation-carriers-have-a-lower-number-of-mature-oocytes-after-ovarian-stimulation-for-ivf-pgd
#11
I A P Derks-Smeets, T C van Tilborg, A van Montfoort, L Smits, H L Torrance, M Meijer-Hoogeveen, F Broekmans, J C F M Dreesen, A D C Paulussen, V C G Tjan-Heijnen, I Homminga, M M J van den Berg, M G E M Ausems, M de Rycke, C E M de Die-Smulders, W Verpoest, R van Golde
PURPOSE: The aim of this study was to determine whether BRCA1/2 mutation carriers produce fewer mature oocytes after ovarian stimulation for in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD), in comparison to a PGD control group. METHODS: A retrospective, international, multicenter cohort study was performed on data of first PGD cycles performed between January 2006 and September 2015. Data were extracted from medical files. The study was performed in one PGD center and three affiliated IVF centers in the Netherlands and one PGD center in Belgium...
August 22, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28768567/in-vitro-growth-and-development-of-isolated-secondary-follicles-from-vitrified-caprine-ovarian-cortex
#12
Érica S S Leal, Luis A Vieira, Naíza A R Sá, Gerlane M Silva, Franciele O Lunardi, Anna C A Ferreira, Cláudio C Campello, Benner G Alves, Francielli W S Cibin, Johan Smitz, José R Figueiredo, Ana P R Rodrigues
The aim of this study was to evaluate the viability, antrum formation and in vitro development of isolated secondary follicles from vitrified caprine ovarian cortex in a medium previously established for fresh isolated secondary follicles, in the absence (α-minimum essential medium (α-MEM+) alone) or presence of FSH and vascular endothelial growth factor (VEGF; α-MEM++FSH+VEGF). Ovarian fragments were distributed among five treatments (T1 to T5): fresh follicles were fixed immediately (T1), follicles from fresh tissue were cultured in vitro in α-MEM+ (T2) or α-MEM++FSH+VEGF (T3) and follicles from vitrified tissue were cultured in vitro in α-MEM+ (T4) or α-MEM++FSH+VEGF (T5)...
August 3, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28742191/high-progesterone-levels-during-the-luteal-phase-related-to-the-use-of-an-aromatase-inhibitor-in-breast-cancer-patients
#13
C Alviggi, R Marci, R Vallone, A Conforti, F Di Rella, I Strina, S Picarelli, P De Rosa, M De Laurentiis, C Yding Andersen, G De Placido
OBJECTIVE: To evaluate the hormonal profile in three breast cancer patients who underwent controlled ovarian stimulation in the presence of the aromatase inhibitor letrozole. PATIENTS AND METHODS: In IVF University referral center, a case series of three breast cancer patients who underwent controlled ovarian stimulation (COS) with recombinant FSH and letrozole were investigated. Ovulation was induced with hCG (case No. 1) or with GnRH agonist (case No. 2-3). The primary outcome of our study was the detection of progesterone levels in the luteal phase...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28722192/roles-of-fas-fasl-mediated-apoptosis-and-inhibin-b-in-the-testicular-dysfunction-of-rats-with-left-side-varicocele
#14
J Zhang, P P Jin, M Gong, J H Guo, K Fang, Q T Yi, R J Zhu
We investigated the role of the Fas/FasL signalling pathway and inhibin B expression in rats with an experimentally induced left-side varicocele. Forty-five Sprague Dawley (SD) male rats were randomly divided into three groups in average: control group, sham group and experimental group. The expression of inhibin B in the rat left testis was analysed at the mRNA and protein levels by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting respectively. The expressions of Fas, FasL and caspase-3 in the left testis were measured by RT-PCR and immunofluorescence...
July 18, 2017: Andrologia
https://www.readbyqxmd.com/read/28710053/stimulation-of-the-ovaries-in-women-with-breast-cancer-undergoing-fertility-preservation-alternative-versus-standard-stimulation-protocols-the-study-protocol-of-the-stim-trial
#15
T Dahhan, E M E Balkenende, C C M Beerendonk, K Fleischer, D Stoop, A M E Bos, C B Lambalk, R Schats, R J T van Golde, I Schipper, L A Louwé, A E P Cantineau, J M J Smeenk, J P de Bruin, N Reddy, Y Kopeika, F van der Veen, M van Wely, S C Linn, M Goddijn
BACKGROUND: Chemotherapy for breast cancer may have a negative impact on reproductive function due to gonadotoxicity. Fertility preservation via banking of oocytes or embryos after ovarian stimulation with FSH can increase the likelihood of a future live birth. It has been hypothesized that elevated serum estrogen levels during ovarian stimulation may induce breast tumour growth. This has led to the use of alternative stimulation protocols with addition of tamoxifen or letrozole. The effectiveness of these stimulation protocols in terms of oocyte yield is unknown...
July 11, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28708520/ovulation-rate-antral-follicle-count-and-circulating-anti-m%C3%A3-llerian-hormone-in-trio-allele-carriers-a-novel-high-fecundity-bovine-genotype
#16
Alvaro García-Guerra, Jéssica C L Motta, Leonardo F Melo, Brian W Kirkpatrick, Milo C Wiltbank
High fecundity genotypes in sheep are a valuable model to study the physiological mechanisms underlying follicle selection and the control of ovulation rate. Similar genotypes in cattle had not been described until the recent identification of a major bovine allele, termed Trio, which had a large effect on ovulation rate. The present study was designed to evaluate ovulation rate, antral follicle count (AFC), circulating ant-müllerian hormone (AMH), and the association among these measures in unstimulated and superstimulated Trio carrier cattle...
June 3, 2017: Theriogenology
https://www.readbyqxmd.com/read/28708493/effects-of-fsh-addition-to-an-enriched-medium-containing-insulin-and-egf-after-long-term-culture-on-functionality-of-equine-ovarian-biopsy-tissue
#17
F L N Aguiar, G D A Gastal, G M Ishak, M O Gastal, D I A Teixeira, J M Feugang, J R Figueiredo, E L Gastal
The effect of FSH supplementation on an enriched cultured medium containing insulin (10 ng/mL) and EGF (50 ng/mL) was investigated on in vitro culture of equine ovarian biopsy tissue. Ovarian tissue fragments were collected from mares (n = 10) and distributed in the following treatments: noncultured control, cultured control, and cultured + FSH. Both treated groups were cultured for 7 or 15 days. The end points evaluated were: follicular morphology, estradiol levels in the culture medium, fluorescence intensity for TUNEL, EGFR and Ki-67 detection, and gene expression of GDF-9, BMP-15, and Cyclin-D2 in the ovarian tissue...
April 28, 2017: Theriogenology
https://www.readbyqxmd.com/read/28697822/-diagnostic-value-of-baseline-serum-luteinizing-hormone-level-for-central-precocious-puberty-in-girls
#18
Li-Xue Ou-Yang, Fan Yang
OBJECTIVE: To evaluate the diagnostic value of baseline serum luteinizing hormone (LH) level for central precocious puberty (CPP) in girls. METHODS: A total of 279 girls with precocious puberty were subjected to assessment of growth and development, bone age determination, baseline LH test, and follicle-stimulating hormone (FSH) test, gonadotropin-releasing hormone stimulation test, and other related examinations. Of the 279 patients, 175 were diagnosed with CPP and 104 with premature thelarche (PT)...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28670424/a-comparison-of-outcomes-from-in-vitro-fertilization-cycles-stimulated-with-follicle-stimulating-hormone-plus-either-recombinant-luteinizing-hormone-or-human-menopausal-gonadotropins-in-subjects-treated-with-long-gonadotropin-releasing-hormone-agonist-protocols
#19
Nathalie Bleau, Mohammed Agdi, WeonYoung Son, SeangLin Tan, Michael H Dahan
BACKGROUND: This study compared rates of pregnancy and in vitro fertilization (IVF) parameters in subjects stimulated with follicle stimulating hormone (FSH) plus either recombinant human luteinizing hormone (r-LH) or human menopausal gonadotropin (hMG) in a long gonadotropin releasing hormone (GnRH) agonist IVF protocol. MATERIALS AND METHODS: This cohort study enrolled patients who underwent IVF stimu- lation with a long GnRH agonist protocol and received FSH plus r-LH or hMG...
July 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28656538/the-dilemma-of-counseling-patients-about-poor-prognosis-live-birth-after-ivf-with-autologous-oocytes-in-a-43-year-old-woman-with-fsh-levels-above-30%C3%A2-miu-ml
#20
Heather R Burks, Marsha Baker, Alexander M Quaas, Kristin A Bendikson, Karine Chung, Richard J Paulson
Providing reasonable expectations to patients with diminished ovarian reserve prior to attempting pregnancy through in vitro fertilization (IVF) is one of the most challenging aspects of fertility care. In some instances, advice from the clinician to pursue more effective treatment, such as donor oocytes, may not be acceptable to the patient. In this case report, a patient is presented who represents a poor prognosis candidate for IVF treatment. She was 43 years old with six prior failed IVF cycles and repetitive basal FSH values above 30 mIU/mL...
June 27, 2017: Journal of Assisted Reproduction and Genetics
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