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https://www.readbyqxmd.com/read/28944967/risk-for-chromosomal-aberrations-in-apparently-isolated-intra-uterine-growth-restriction-a-systematic-review
#1
REVIEW
Lena Sagi-Dain, Amir Peleg, Shlomi Sagi
OBJECTIVE: To perform a systematic review examining the risk of chromosomal aberrations in apparently isolated intra-uterine growth restriction (IUGR). METHODS: Search was conducted by research librarian in five databases. By independent screening of 2894 references, two investigators selected original studies examining the risk of chromosomal aberrations in apparently isolated IUGR diagnosed at the second and third trimesters using ultrasound. We excluded studies describing IUGR combined with additional fetal anomalies detected by ultrasound and those where fetuses with structural anomalies or aneuploidy were not reported...
September 25, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28943228/effect-of-lactobacillus-rhamnosus-hn001-in-pregnancy-on-postpartum-symptoms-of-depression-and-anxiety-a-randomised-double-blind-placebo-controlled-trial
#2
R F Slykerman, F Hood, K Wickens, J M D Thompson, C Barthow, R Murphy, J Kang, J Rowden, P Stone, J Crane, T Stanley, P Abels, G Purdie, R Maude, E A Mitchell
BACKGROUND: Probiotics may help to prevent symptoms of anxiety and depression through several putative mechanisms. OBJECTIVE: The aim of this study was to evaluate the effect of Lactobacillus rhamnosus HN001 (HN001) given in pregnancy and postpartum on symptoms of maternal depression and anxiety in the postpartum period. This was a secondary outcome, the primary outcome being eczema in the offspring at 12months of age. DESIGN, SETTING, PARTICIPANTS: A randomised, double-blind, placebo-controlled trial of the effect of HN001 on postnatal mood was conducted in 423 women in Auckland and Wellington, New Zealand...
September 14, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28942700/clinical-analysis-of-the-patients-with-single-fair-cleavage-stage-embryo-on-day-3
#3
Mingzhao Li, Hui Wang, Xia Xue, Juanzi Shi
OBJECTIVE: This study aimed to explore an appropriate selection for the patients with single fair cleavage-stage embryo on day 3. METHODS: This study included 469 fresh transfers and 220 frozen-thawed transfers from January 2014 to June 2016. Furthermore, in 72 patients who have only 4-6 fair embryos (4-5 blastomeres) on day 3, the blastocysts were cultured to day 5 for transfer. RESULTS: In the fresh transfers, the clinical pregnancy rate of 4-5 blastomeres group was significantly lower than 6-7 and 8-10 blastomeres group (5...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28942691/twin-transvaginal-cervical-length-at-16-20%C3%A2-weeks-and-prediction-of-preterm-birth
#4
Ashley E Hester, Nana-Ama E Ankumah, Suneet P Chauhan, Sean C Blackwell, Baha M Sibai
OBJECTIVE: Our objective was to determine if transvaginal cervical length at 16-20 weeks is predictive of preterm birth < 34 weeks in a large cohort of twin pregnancies. STUDY DESIGN: This is a secondary analysis from a randomized trial of 17 alpha-hydroxyprogesterone caproate in twins to prevent preterm birth. Transvaginal cervical length was performed at 16-20-week gestation. The inclusion criteria were nonanomalous twins with transvaginal cervical length at 16-20 weeks...
September 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28942518/projecting-the-potential-impact-of-the-cap-score%C3%A2-on-clinical-pregnancy-live-births-and-medical-costs-in-couples-with-unexplained-infertility
#5
Joseph B Babigumira, Fady I Sharara, Louis P Garrison
PURPOSE: The Cap-Score™ was developed to assess the capacitation status of men, thereby enabling personalized management of unexplained infertility by choosing timed intrauterine insemination (IUI), versus immediate in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) in individuals with a low Cap-Score™. The objective of this study was to estimate the differences in outcomes and costs comparing the use of the Cap-Score™ with timed IUI (CS-TI) and the standard of care (SOC), which was assumed to be three IUI cycles followed by three IVF-ICSI cycles...
September 23, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28940428/maternal-alcohol-use-and-nutrition-during-pregnancy-diet-and-anthropometry
#6
R Colin Carter, Marjanne Senekal, Neil C Dodge, Lori Bechard, Ernesta M Meintjes, Christopher D Molteno, Christopher Duggan, Joseph L Jacobson, Sandra W Jacobson
BACKGROUND: Despite known risks of prenatal nutritional deficiencies and studies documenting increased prevalence of poor dietary intake among non-pregnant alcohol abusers, the nutritional status of heavy drinking pregnant women remains largely unstudied. Animal models have found interactions between prenatal ethanol exposure and micronutrients, such as choline, folate, B12, and iron, and human studies have reported that lower maternal weight and body mass confer increased fetal alcohol-related risk...
September 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28940191/weekend-free-scheduled-ivf-icsi-procedures-and-single-embryo-transfer-do-not-reduce-live-birth-rates-in-a-general-infertile-population
#7
Michael Feichtinger, Per Olof Karlström, Jan I Olofsson, Kenny A Rodriguez-Wallberg
INTRODUCTION: Scheduling of ovum pickups (OPU) only on weekdays may result in cases of apparently suboptimal timing for human chorionic gonadotropin (hCG) and OPU. This study aimed to assess whether live-birth rates were reduced in women with a potentially suboptimal day for hCG and OPU to avoid week-end work, according to ultrasonographic data on the day of hCG planning. MATERIAL AND METHODS: An evaluation of the optimal hCG priming date was performed in treatment protocols of 1000 consecutive patients undergoing their first in vitro fertilization /intracytoplasmatic sperm injection (IVF/ICSI) with single-embryo transfer...
September 20, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28940130/comparison-of-pregnancy-outcomes-after-vitrification-at-the-cleavage-and-blastocyst-stage-a-meta-analysis
#8
REVIEW
MeiFang Zeng, SuQin Su, LiuMing Li
OBJECTIVE: This systematic review sought to evaluate the clinical outcomes of vitrification at the cleavage stage and blastocyst stage for embryo transfer in patients undergoing assisted reproductive technology (ART) treatment. METHODS: We searched for related comparative studies published in the PubMed, EMBASE, and Cochrane Library databases up to July 2017. The primary outcomes were clinical pregnancy rate (CPR) and embryo implantation rate (IR). Secondary outcomes were multiple pregnancy rate (MPR), miscarriage rate (MR), live birth rate (LBR), and ongoing pregnancy rate (OPR)...
September 22, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28939862/surgical-site-infections-following-caesarean-operations-at-a-jordanian-teaching-hospital-frequency-and-implicated-factors
#9
Mariam Hantash Abdel Jalil, Khawla Abu Hammour, Mervat Alsous, Wedad Awad, Rand Hadadden, Faris Bakri, Kamil Fram
Surgical site infections (SSIs) following caesarean surgeries are common. The present study aimed to evaluate the frequency of SSIs following caesareans at Jordan University Hospital during the 30 postoperative days and to identify factors associated with increased SSIs risk. Data regarding the occurrence of SSIs were collected both prospectively via follow-up phone calls and retrospectively via reviewing wound culture results and clinical notes. SSI cases were subsequently determined utilizing predefined criteria...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28939582/a-randomised-controlled-trial-of-an-intervention-delivered-by-app-instant-messaging-to-increase-the-acceptability-of-effective-contraception-among-young-people-in-tajikistan-study-protocol
#10
Ona McCarthy, Baptiste Leurent, Phil Edwards, Ravshan Tokhirov, Caroline Free
INTRODUCTION: Women in lower income countries experience unintended pregnancies at a higher rate compared with women in higher income countries. Unintended pregnancy is associated with numerous poorer health outcomes for both women and their children. In Tajikistan, an estimated 26% of married individuals aged 15-24 years have an unmet need for contraception. The strong cultural value placed on childbearing and oppositional attitudes towards contraception are major barriers to contraceptive uptake in the country...
September 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28939493/improving-screening-for-alcohol-consumption-during-pregnancy-with-phosphatidylethanol
#11
Luis A Bracero, Stefan Maxwell, Afua Nyanin, Dara J Seybold, April White, Mike Broce
OBJECTIVE: The study objective was to compare rates of alcohol use between urine ethanol testing and self- reporting (Method: 1) and Phosphatidylethanol (PEth) dried blood spot testing and self-reporting (Method: 2). METHODS: This was a prospective observational study in an obstetric clinic with universal alcohol screening. RESULTS: Method: 1 identified 11 patients with alcohol use (5 urine and 6 self-reported); Method: 2 identified 28 (22 PEth and 6 self-reported) out of 315 patients (one patient positive for both urine and PEth)...
September 19, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28938896/effect-of-local-endometrial-injury-in-proliferative-vs-luteal-phase-on-ivf-outcomes-in-unselected-subfertile-women-undergoing-in-vitro-fertilization
#12
Wenjie Liu, Reshef Tal, He Chao, Minghui Liu, Ying Liu
BACKGROUND: Mechanical endometrial injury prior to IVF has been suggested as a means to increase implantation rates by improving endometrial receptivity. However, the effects of endometrial injury in proliferative vs. luteal phase have not been studied before. This study aimed to explore whether endometrial injury in the proliferative phase of the preceding cycle before in vitro fertilization/embryo transfer (IVF-ET) improves the clinical outcomes in unselected subfertile women compared with injury in luteal phase...
September 22, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28938878/variation-in-clinical-decision-making-for-induction-of-labour-a-qualitative-study
#13
Tanya A Nippita, Maree Porter, Sean K Seeho, Jonathan M Morris, Christine L Roberts
BACKGROUND: Unexplained variation in induction of labour (IOL) rates exist between hospitals, even after accounting for casemix and hospital differences. We aimed to explore factors that influence clinical decision-making for IOL that may be contributing to the variation in IOL rates between hospitals. METHODS: We undertook a qualitative study involving semi-structured, audio-recorded interviews with obstetricians and midwives. Using purposive sampling, participants known to have diverse opinions on IOL were selected from ten Australian maternity hospitals (based on differences in hospital IOL rate, size, location and case-mix complexities)...
September 22, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28938734/hyperspectral-microscopy-can-detect-metabolic-heterogeneity-within-bovine-post-compaction-embryos-incubated-under-two-oxygen-concentrations-7-versus-20
#14
Melanie L Sutton-McDowall, Martin Gosnell, Ayad G Anwer, Melissa White, Malcolm Purdey, Andrew D Abell, Ewa M Goldys, Jeremy G Thompson
STUDY QUESTION: Can we separate embryos cultured under either 7% or 20% oxygen atmospheres by measuring their metabolic heterogeneity? SUMMARY ANSWER: Metabolic heterogeneity and changes in metabolic profiles in morula exposed to two different oxygen concentrations were not detectable using traditional fluorophore and two-channel autofluorescence but were detectable using hyperspectral microscopy. WHAT IS KNOWN ALREADY: Increased genetic and morphological blastomere heterogeneity is associated with compromised developmental competence of embryos and currently forms the basis for embryo scoring within the clinic...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28937912/postpartum-contraceptive-use-and-rapid-repeat-pregnancy-among-women-who-use-substances
#15
Amy M Loree, Aileen Gariepy, Jennifer Prah Ruger, Kimberly A Yonkers
BACKGROUND: Postpartum contraception is especially important for women who use alcohol and other substances, given the risk of possible rapid repeat pregnancy and prenatal substance exposure. However, little is known about postpartum contraceptive use among women with substance use histories. OBJECTIVE: To characterize postpartum contraceptive initiation, 24-month continuation, and rapid repeat pregnancy among women who used substances during pregnancy. METHODS: This is a secondary analysis of 161 pregnant women who enrolled in a randomized clinical trial to treat substance use in pregnancy and completed at least one follow-up assessment...
September 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28935366/review-diagnosis-and-impact-of-sperm-dna-alterations-in-assisted-reproduction
#16
REVIEW
Luke Simon, Benjamin R Emery, Douglas T Carrell
Sperm nuclear and chromatin abnormalities are common among infertile men and are known to influence natural reproduction. These abnormalities are also considered detrimental to normal fertilization, embryo development, and successful implantation and pregnancies following assisted reproductive treatment (ART). Abnormalities in the sperm nucleus can be broadly classified into sperm chromosomal abnormalities (aneuploidies) and sperm DNA abnormalities such as abnormal packing, DNA integrity, or DNA fragmentation...
August 2, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28935064/no-231-guidelines-for-the-management-of-vasa-previa
#17
Robert Gagnon
OBJECTIVES: To describe the etiology of vasa previa and the risk factors and associated condition, to identify the various clinical presentations of vasa previa, to describe the ultrasound tools used in its diagnosis, and to describe the management of vasa previa. OUTCOMES: Reduction of perinatal mortality, short-term neonatal morbidity, long-term infant morbidity, and short-term and long-term maternal morbidity and mortality. EVIDENCE: Published literature on randomized trials, prospective cohort studies, and selected retrospective cohort studies was retrieved through searches of PubMed or Medline, CINAHL, and the Cochrane Library, using appropriate controlled vocabulary (e...
October 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28935057/no-349-substance-use-in-pregnancy
#18
Alice Ordean, Suzanne Wong, Lisa Graves
OBJECTIVES: To improve awareness and knowledge of problematic substance use in pregnancy and to provide evidence-based recommendations for the management of this challenging clinical issue for all health care providers. OPTIONS: This guideline reviews the use of screening tools, general approach to care, and recommendations for the clinical management of problematic substance use in pregnancy. OUTCOMES: Evidence-based recommendations for screening and management of problematic substance use during pregnancy and lactation...
October 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28934086/towards-ontology-based-decision-support-systems-for-complex-ultrasound-diagnosis-in-obstetrics-and-gynecology
#19
P Maurice, F Dhombres, E Blondiaux, S Friszer, L Guilbaud, N Lelong, B Khoshnood, J Charlet, N Perrot, E Jauniaux, D Jurkovic, J-M Jouannic
INTRODUCTION: We have developed a new knowledge base intelligent system for obstetrics and gynecology ultrasound imaging, based on an ontology and a reference image collection. This study evaluates the new system to support accurate annotations of ultrasound images. We have used the early ultrasound diagnosis of ectopic pregnancies as a model clinical issue. MATERIAL AND METHODS: The ectopic pregnancy ontology was derived from medical texts (4260 ultrasound reports of ectopic pregnancy from a specialist center in the UK and 2795 Pubmed abstracts indexed with the MeSH term "Pregnancy, Ectopic") and the reference image collection was built on a selection from 106 publications...
May 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28934082/evaluation-of-adherence-to-french-clinical-practice-guidelines-in-the-management-of-pregnancy-loss-issued-by-the-french-college-of-obstetricians-and-gynecologists-one-year-after-publication-a-vignette-based-study
#20
S Le Gouic, V Lavoué, M Mimouni, J Levêque, C Huchon
OBJECTIVES: To assess the adhesion of French obstetricians and gynecologists to the French clinical practice guidelines for pregnancy loss, issued by the French College of Obstetricians and Gynecologists, one year after publication. METHODS: An online vignette-based study was emailed to a sample of French obstetricians and gynecologists to compare their management of women with missed early miscarriage and incomplete early miscarriage. A descriptive statistical analysis was performed comparing the rates of appropriate management for these two indications before and after the release of the guidelines...
May 2017: Journal of gynecology obstetrics and human reproduction
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