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https://www.readbyqxmd.com/read/28802706/the-impact-of-adenomyosis-on-the-outcome-of-ivf-embryo-transfer
#1
Dimitrios Mavrelos, Tom K Holland, Oliver O'Donovan, Mohamed Khalil, George Ploumpidis, Davor Jurkovic, Yakoub Khalaf
Our study examined the impact of adenomyosis on the chance of clinical pregnancy after IVF and embryo transfer (IVF-ET). This was a prospective multicentre study from April 2013 to October 2015. We included 375 women with history of infertility who attended for a 3D scan prior to IVF-ET. A total of 150/375 (40.0%, 95% confidence interval [CI] 35.2-45.0) women had clinical pregnancy. Women with any feature of adenomyosis had a lower clinical pregnancy rate (21/72 [29.2%, 95% CI 18.6-39.6] versus 129/303 [42...
July 29, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28802704/early-miscarriage-rate-in-lean-polycystic-ovary-syndrome-women-after-euploid-embryo-transfer-a-matched-pair-study
#2
Lu Luo, Fang Gu, Huying Jie, Chenhui Ding, Qiang Zhao, Qiong Wang, Canquan Zhou
The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PCOS is still unknown. In this 1:3 matched-pair study, 67 lean PCOS patients and 201 controls matched for age, body mass index (BMI) and embryo scores undergoing a single euploid blastocyst transfer in vitrified-warmed cycles were analysed...
July 29, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28801637/effect-of-golph3-on-cumulus-granulosa-cell-apoptosis-and-icsi-pregnancy-outcomes
#3
Dianliang Lin, Jing Ran, Suqin Zhu, Song Quan, Baofeng Ye, Aili Yu, Yuefan Kang, Yuan Lin
Previous studies have shown that GOLPH3 mediates cell growth, proliferation and differentiation and inhibits cell apoptosis; however, the role of GOLPH3 in cumulus granulosa cells and the value of GOLPH3 in predicting ICSI pregnancy outcomes remain unknown until now. Our findings showed higher positive expression rate, score of staining intensity, and immunohistochemical score of GOLPH3 in the cumulus granulosa cells of the pregnant women relative to non-pregnant women, and a higher apoptotic rate of cumulus granulosa cells was detected in non-pregnant women than in pregnant women...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800968/routine-%C3%AE-hcg-monitoring-for-single-dose-methotrexate-treatment-in-ectopic-pregnancy
#4
Yuxin Dai, Guorui Zhang, Lan Zhu, Jinghe Lang, Zhufeng Liu
STUDY OBJECTIVE: To evaluate an alternative monitoring protocol without D4 β-HCG measurement for predicting the need for a repeated methotrexate (MTX) dose in patients undergoing single-dose MTX therapy for ectopic pregnancy. DESIGN: Single center, Retrospective study (Canadian Task Force classification II-3). SETTING: University-affiliated hospital. PATIENTS: 184 ectopic pregnancy patients who were treated with MTX between January 2009 and December 2016 were included in the study...
August 8, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28799634/effectiveness-of-highly-purified-urofollitropin-treatment-in-patients-with-idiopathic-azoospermia-before-testicular-sperm-extraction
#5
Andrea Cocci, Gianmartin Cito, Giorgio I Russo, Marco Falcone, Marco Capece, Massimiliano Timpano, Pier Andrea Della Camera, Simone Morselli, Giovanni Tasso, Girolamo Morelli, Giuseppe Morgia, Andrea Minervini, Sergio Serni, Marco Carini, Alessandro Natali, Mauro Gacci
INTRODUCTION: Recent evidences demonstrated that male factor alone is responsible for about 30% cases of infertility. Human follicle-stimulating hormone (hFSH) has been introduced to increase sperm concentration, spermatogonial population, or both natural or assisted pregnancy rates (PRs) in oligozoospermic subjects with normal concentrations of gonadotropins. METHODS: Fifty infertile men affected by idiopathic azoospermia were enrolled in this study, after undergoing medical history, physical and clinical examination, baseline semen parameters and hormonal plasma concentrations...
August 7, 2017: Urologia
https://www.readbyqxmd.com/read/28799257/comparison-of-costs-associated-with-substituting-culture-medium-with-saline-solution-for-follicular-flushing-during-oocyte-retrieval
#6
Dmitry Loktionov, Oladayo Oduola, Jenny Cloherty, Sharon M Warner, Nikhil Purandare
OBJECTIVES: To compare culture medium and saline solution for follicular flushing during oocyte retrieval with assisted reproductive technologies. METHODS: The present retrospective study analyzed data collected at Galway Fertility Clinic, Galway, Ireland, between January 1, 2015, and August 31, 2016; all patients attending the clinic for in vitro fertilization/intracytoplasmic sperm injection during this period were included. Data were stratified by whether follicular flushing was performed with culture medium or saline, and the oocyte yield rate, fertilization rate, embryo utilization rate, and biochemical and clinical pregnancy rates were compared between the groups...
August 11, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28797287/is-a-high-serum-copper-concentration-a-risk-factor-for-implantation-failure
#7
Hidehiko Matsubayashi, Kotaro Kitaya, Kohei Yamaguchi, Rie Nishiyama, Yukiko Takaya, Tomomoto Ishikawa
BACKGROUND: Copper-containing contraceptive devices may deposit copper ions in the endometrium, resulting in implantation failure. The deposition of copper ions in many organs has been reported in patients with untreated Wilson's disease. Since these patients sometimes exhibit subfertility and/or early pregnancy loss, copper ions were also considered to accumulate in the uterine endometrium. Wilson's disease patients treated with zinc successfully delivered babies because zinc interfered with the absorption of copper from the gastrointestinal tract...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28796681/vasa-previa-diagnosis-clinical-practice-and-outcomes-in-australia
#8
Elizabeth A Sullivan, Nasrin Javid, Gregory Duncombe, Zhuoyang Li, Nadom Safi, Robert Cincotta, Caroline S E Homer, Lesley Halliday, Yinka Oyelese
OBJECTIVE: To estimate the incidence of women with vasa previa in Australia and to describe risk factors, timing of diagnosis, clinical practice, and perinatal outcomes. METHODS: A prospective population-based cohort study was undertaken using the Australasian Maternity Outcomes Surveillance System between May 1, 2013, and April 30, 2014, in hospitals in Australia with greater than 50 births per year. Women were included if they were diagnosed with vasa previa during pregnancy or childbirth, confirmed by clinical examination or placental pathology...
August 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28795051/predictors-of-live-birth-and-pregnancy-success-after-in-vitro-fertilization-in-infertile-women-aged-40-and-over
#9
Hye Ok Kim, Nayoung Sung, In Ok Song
OBJECTIVE: The aim of this study was to evaluate pregnancy outcomes and the live birth rate at 1-year age increments in women aged ≥40 years undergoing fresh non-donor in vitro fertilization (IVF) and embryo transfer (ET), and to identify predictors of success in these patients. METHODS: This retrospective study was performed among women ≥40 years of age between 2004 and 2011. Of the 2,362 cycles that were conducted, ET was performed in 1,532 (73.1%). RESULTS: The clinical pregnancy rate and live birth rate in women ≥40 years significantly decreased with each year of increased age (p<0...
June 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28795050/mixed-double-embryo-transfer-a-promising-approach-for-patients-with-repeated-implantation-failure
#10
Georgi Stamenov Stamenov, Dimitar Angelov Parvanov, Todor Angelov Chaushev
OBJECTIVE: The purpose of this study was to evaluate the efficacy of frozen mixed double-embryo transfer (MDET; the simultaneous transfer of day 3 and day 5 embryos) in comparison with frozen blastocyst double-embryo transfer (BDET; transfer of two day 5 blastocysts) in patients with repeated implantation failure (RIF). METHODS: A total of 104 women with RIF who underwent frozen MDET (n=48) or BDET (n=56) with excellent-quality embryos were included in this retrospective analysis...
June 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28795047/influence-of-the-insemination-method-on-the-outcomes-of-elective-blastocyst-culture
#11
Caizhu Wang, Guixue Feng, Bo Zhang, Jinhui Shu, Hong Zhou, Xianyou Gan, Ruoyun Lin
OBJECTIVE: The aim of this study was to explore the effects of the insemination method on the outcomes of elective blastocyst culture. METHODS: We retrospectively analyzed the outcomes of elective blastocyst culture performed between January 2011 and December 2014. RESULTS: There were 2,003 cycles of conventional in vitro fertilization (IVF) and 336 cycles of intracytoplasmic sperm injection (ICSI), including 25,652 and 4,164 embryos that underwent sequential blastocyst culture, respectively...
June 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28792712/external-quality-assessment-of-first-trimester-prenatal-biochemical-screening-in-china
#12
Shishi Zhang, Xiaoyan Zhang, Wei Wang, Falin He, Kun Zhong, Shuai Yuan, Zhiguo Wang
BACKGROUND: Free β subunit of human chorionic gonadotropin (free β-hCG) and pregnancy-associated plasma protein A (PAPP-A) are two important biomarkers in first-trimester prenatal screening. This study intended to reflect their analytical performance in clinical laboratories and main platforms of the 2015 External Quality Assessment (EQA) scheme for the first-trimester biochemical screening in China. METHODS: Ten lyophilized EQA samples, divided into two sets and analyzed in two cycles 20151 and 20152, were distributed to each participant in 2015...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28791974/experience-with-the-bonanno-catheter-in-the-management-of-ohss-from-ivf-et-cycles
#13
J E Okohue, V K Oriji, J I Ikimalo
OBJECTIVE: To document our experience with the use of the Bonanno catheter as a closed abdominal drain for OHSS Methods: A retrospective study of all IVF embryo transfer (ET) treatment cycles carried out between May 2006 and April 2009 at a dedicated IVF centre. Case notes of patients with OHSS were retrieved and the outcome of the continuous closed abdominal drain with Bonanno catheter documented. RESULT: Within the period under review, 234 patients had controlled ovarian stimulation with ultrasound guided egg retrieval...
July 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28790788/artemisinin-naphthoquine-combination-a-directly-observed-treatment-option-in-malaria
#14
M S Mustafa, V Rastogi
Resistance to standard antimalarials has led to the need for newer options. Artemisinin-based combination therapies (ACTs), which require a tedious three-day treatment schedule, have been introduced for the treatment of drug-resistant malaria. Of late, the new generation artemisinin-naphthoquine (ANQ) combination has been developed, which requires a single dose treatment. Artemisinin initiates the action through the cleavage of the endoperoxide bridge while naphtoquine maintains the process by getting concentrated in the digestive vacuole of the parasite...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28783116/teratogenic-effects-of-topiramate-in-a-zebrafish-model
#15
Yu-Heng Lai, Yu-Ju Ding, David Moses, Yau-Hung Chen
Topiramate is commonly used for treating epilepsy in both children and adults. Recent clinical data suggests that administration of topiramate to women during pregnancy increases the risk of oral clefts in their offspring. To better understand the potential effects of topiramate, we dosed adult female zebrafish with topiramate, and investigated the altered morphologies in adult females and their offspring. It showed that topiramate-treated female fish had reduced oocyte maturation, and the survival rates of their offspring were seriously decreased during embryogenesis...
August 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28782392/model-of-obstetric-attention-based-on-critical-care-in-latin-america
#16
María F Escobar, Javier A Carvajal, Albaro J Nieto, Adriana Messa, Juan M Burgos, Maria P Echavarría, Marcela Granados
Purpose of this article. Report the results obtained following the implementation of an OCC (Obstetric Critical Care) model. MATERIALS AND METHODS: This is an observational prospective study in obstetric population with high complexity illness attended in a safety and quality model of attention in a specific unit supporting the concept of obstetric critical care. Records were used as the primary source for collecting information, using the standards of the Center for Clinical Research...
August 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28782142/influence-of-gestational-diabetes-on-the-fetal-autonomic-nervous-system-a-study-using-phase-rectified-signal-averaging-analysis
#17
Silvia M Lobmaier, Javier U Ortiz, Maria Sewald, Alexander Müller, Georg Schmidt, Bernhard Haller, Renate Oberhoffer, Karl T M Schneider, Dino A Giussani, Annette Wacker-Gußmann
OBJECTIVES: Maternal gestational diabetes (GDM) is known to influence fetal physiology. Phase-rectified signal averaging (PRSA), an innovative signal processing technique, can be used to investigate signals obtained from fetal heart. The PRSA calculated variables "average acceleration capacity" (AAC) and "average deceleration capacity" (ADC) are established indices of autonomic nervous system (ANS) function. The aim of this study was to evaluate the influence of gestational diabetes on the fetal ANS in human pregnancy using PRSA...
August 7, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28781890/self-reported-pregnancy-exposures-and-placental-dna-methylation-in-the-marbles-prospective-autism-sibling-study
#18
Rebecca J Schmidt, Diane I Schroeder, Florence K Crary-Dooley, Jacqueline M Barkoski, Daniel J Tancredi, Cheryl K Walker, Sally Ozonoff, Irva Hertz-Picciotto, Janine M LaSalle
Human placenta is a fetal-derived tissue that offers a unique sample of epigenetic and environmental exposures present in utero. In the MARBLES prospective pregnancy study of high-risk younger siblings of children with autism spectrum disorder (ASD), pregnancy and environmental factors collected by maternal interviews were examined as predictors of placental DNA methylation, including partially methylated domains (PMDs), an embryonic feature of the placental methylome. DNA methylation data from MethylC-seq analysis of 47 placentas of children clinically diagnosed at 3 years with ASD or typical development using standardized assessments were examined in relation to: child's gestational age, birth-weight, and diagnosis; maternal pre-pregnancy body mass index, smoking, education, parity, height, prenatal vitamin and folate intake; home ownership; pesticides professionally applied to lawns or gardens or inside homes, pet flea/tick pouches, collars, or soaps/shampoos used in the 3 months prior to or during pregnancy...
December 2016: Environmental Epigenetics
https://www.readbyqxmd.com/read/28780551/the-indigenous-counselling-and-nicotine-ican-quit-in-pregnancy-pilot-study-protocol-a-feasibility-step-wedge-cluster-randomised-trial-to-improve-health-providers-management-of-smoking-during-pregnancy
#19
Yael Bar-Zeev, Billie Bonevski, Michelle Bovill, Maree Gruppetta, Chris Oldmeadow, Kerrin Palazzi, Lou Atkins, Jennifer Reath, Gillian S Gould
INTRODUCTION: Indigenous women have the highest smoking prevalence during pregnancy (47%) in Australia. Health professionals report lack of knowledge, skills and confidence to effectively manage smoking among pregnant women in general. We developed a behaviour change intervention aimed to improve health professionals' management of smoking in Indigenous pregnant women-the Indigenous Counselling And Nicotine (ICAN) QUIT in Pregnancy. This intervention includes webinar training for health professionals, an educational resources package for health professionals and pregnant women, free oral nicotine replacement therapy (NRT) for pregnant women, and audit and feedback on health professionals' performance...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28777972/maternal-posttraumatic-stress-disorder-during-the-perinatal-period-and-child-outcomes-a-systematic-review
#20
REVIEW
Natalie Cook, Susan Ayers, Antje Horsch
BACKGROUND: Approximately 3.3% of women in pregnancy have posttraumatic stress disorder (PTSD) and 4% of women postpartum PTSD. The impact of maternal PTSD during the perinatal period (from conception until one year postpartum) on child outcomes has not been systematically examined. METHOD: A systematic review was conducted to synthesize and critically evaluate quantitative research investigating the association between perinatal PTSD and child outcomes. Databases EMBASE, BNI, Medline, PsycInfo and CINAHL were searched using specific inclusion and exclusion criteria...
July 27, 2017: Journal of Affective Disorders
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