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https://www.readbyqxmd.com/read/28608999/specimen-acquisition-roses-gardeners-and-gatekeepers
#1
Adele O Kraft
The use of minimally invasive procedures for diagnosis and treatment decisions means that very often cytological samples are the only material available for testing. Cytology has evolved from a strictly morphological approach to the routine use of immunohistochemistry. The advent of personalized medicine has increased the demand for molecular testing, making rapid on-site evaluation even more relevant. This article presents current rapid on-site evaluation practice patterns in different settings, with a special focus on the variety of professionals involved...
June 2017: Cancer
https://www.readbyqxmd.com/read/28602907/an-efficient-architecture-to-support-digital-pathology-in-standard-medical-imaging-repositories
#2
Tiago Marques Godinho, Rui Lebre, Luís Bastião Silva, Carlos Costa
In the past decade, digital pathology and whole-slide imaging (WSI) have been gaining momentum with the proliferation of digital scanners from different manufacturers. The literature reports significant advantages associated with the adoption of digital images in pathology, namely, improvements in diagnostic accuracy and better support for telepathology. Moreover, it also offers new clinical and research applications. However, numerous barriers have been slowing the adoption of WSI, among which the most important are performance issues associated with storage and distribution of huge volumes of data, and lack of interoperability with other hospital information systems, most notably Picture Archive and Communications Systems (PACS) based on the DICOM standard...
July 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28537789/design-and-validation-of-a-low-cost-telepathology-system
#3
Bernardo Meléndez-Álvarez, Omar Robayo, Vicente Gil-Guillén, María Carratalá-Munuera
OBJECTIVE: This work sought to evaluate the precision and repeatability of a telepathology prototype based on open software and hardware. MATERIALS AND METHODS: A prototype was designed with application in telepathology and telemicroscopy. Accuracy and prototype precision were evaluated by calculating the mean absolute error and the intraclass and repeatability correlation coefficients for a series of 190 displacements at 10, 25, 50, 75, and 100 μm. RESULTS AND CONCLUSIONS: This work developed a low-cost prototype that is accessible, easily reproducible, implementable, and scalable; based on the use of technology created under principles of open software and hardware...
May 24, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28480119/evaluation-of-android-smartphones-for-telepathology
#4
Donald Ekong, Fang Liu, G Thomas Brown, Arunima Ghosh, Paul Fontelo
BACKGROUND: In the year 2014, Android smartphones accounted for one-third of mobile connections globally but are predicted to increase to two-thirds by 2020. In developing countries, where teleconsultations can benefit health-care providers most, the ratio is even higher. This study compared the use of two Android phones, an 8 megapixel (MP) and a 16 MP phone, for capturing microscopic images. METHOD: The Android phones were used to capture images and videos of a gastrointestinal biopsy teaching set of referred cases from the Armed Forces Institute of Pathology (AFIP)...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28479695/digital-cytopathology
#5
REVIEW
Roquaiya Nishat, Sujatha Ramachandra, Shyam Sundar Behura, Harish Kumar
The advancements in the fields of technology and networking have revolutionized the world including the fields of medicine and dentistry. Telemedicine and its various branches provide a broad platform to medical professionals for consultations and investigations and can also act as a valuable educational aid. This review highlights the components, methods employed, clinical applications, advantages, disadvantages of telepathology and telecytology.
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28347217/the-evolution-of-publication-hotspots-in-the-field-of-telemedicine-from-1962-to-2015-and-differences-among-six-countries
#6
Yanjun Wang, Ye Zhao, Jianzhong Zheng, Ailian Zhang, Haiyuan Dong
Introduction Telemedicine has been implemented in many countries and has captured the attention of many researchers. Herein, we aim to quantify publication hotspots in the field of telemedicine, analyse their evolution, compare them in different countries, and provide visual representations. Methods We used software tools to process PubMed entries for a 54-year period and identified publication hotspots using keyword frequency analysis. We employed a keyword co-occurrence analysis, principal component analysis, multidimensional scaling analysis, and network visualization technology...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28170313/the-empirical-foundations-of-telepathology-evidence-of-feasibility-and-intermediate-effects
#7
Rashid L Bashshur, Elizabeth A Krupinski, Ronald S Weinstein, Matthew R Dunn, Noura Bashshur
INTRODUCTION: Telepathology evolved from video microscopy (i.e., "television microscopy") research in the early 1950s to video microscopy used in basic research in the biological sciences to a basic diagnostic tool in telemedicine clinical applications. Its genesis can be traced to pioneering feasibility studies regarding the importance of color and other image-based parameters for rendering diagnoses and a series of studies assessing concordance of virtual slide and light microscopy diagnoses...
March 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28157405/an-assessment-of-pathology-resident-access-to-and-use-of-technology-a-nationwide-survey
#8
Bethany D Vallangeon, Jeffrey S Hawley, Richard Sloane, Sarah M Bean
CONTEXT: - Current technologies including digital slide scanners and handheld devices can revolutionize clinical practice and pathology graduate medical education (GME). The extent to which these technologies are used in pathology GME is unknown. OBJECTIVES: - To determine the types of technologies used, usage amount, and how they are integrated into pathology residency/fellowship programs nationwide. DESIGN: - A 40-question online survey for residents/fellows was developed and administered via the Research Electronic Data Capture System after institutional review board approval...
March 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28157404/whole-slide-imaging-for-analytical-anatomic-pathology-and-telepathology-practical-applications-today-promises-and-perils
#9
Alton Brad Farris, Cynthia Cohen, Thomas E Rogers, Geoffrey H Smith
Whole slide imaging (WSI) offers a convenient, tractable platform for measuring features of routine and special-stain histology or in immunohistochemistry staining by using digital image analysis (IA). We now routinely use IA for quantitative and qualitative analysis of theranostic markers such as human epidermal growth factor 2 (HER2/neu), estrogen and progesterone receptors, and Ki-67. Quantitative IA requires extensive validation, however, and may not always be the best approach, with pancreatic neuroendocrine tumors being one example in which a semiautomated approach may be preferable for patient care...
April 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28057717/pathology-driven-comprehensive-proteomic-profiling-of-the-prostate-cancer-tumor-microenvironment
#10
Lisa Staunton, Claire Tonry, Rosina Lis, Virginia Espina, Lance Liotta, Rosanna Inzitari, Michaela Bowden, Aurelie Fabre, John O'Leary, Stephen P Finn, Massimo Loda, Stephen R Pennington
Prostate cancer is the second most common cancer in men worldwide. Gleason grading is an important predictor of prostate cancer outcomes and is influential in determining patient treatment options. Clinical decisions based on a Gleason score of 7 are difficult as the prognosis for individuals diagnosed with Gleason 4+3 cancer is much worse than for those diagnosed with Gleason 3+4 cancer. Laser capture microdissection (LCM) is a highly precise method to isolate specific cell populations or discrete microregions from tissues...
March 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27742174/validation-of-diagnostic-accuracy-with-whole-slide-imaging-compared-with-glass-slide-review-in-dermatopathology
#11
COMPARATIVE STUDY
Kabeer K Shah, Julia S Lehman, Lawrence E Gibson, Christine M Lohse, Nneka I Comfere, Carilyn N Wieland
BACKGROUND: Teledermatopathology has evolved from static images to whole slide imaging (WSI), which allows for remote viewing and manipulation of tissue sections. Previous studies of WSI in teledermatopathology predated College of American Pathologists (CAP) telepathology validation guidelines. OBJECTIVE: We conducted a comprehensive retrospective WSI validation study of routine dermatopathology cases, adhering to CAP guidelines. METHOD: In all, 181 consecutive cases arranged into 3 categories (inflammatory, melanocytic, nonmelanocytic proliferations) were reviewed by 3 board-certified dermatopathologists via traditional microscopy (TM) and WSI...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27708495/needs-assessment-of-pathologists-using-telepathology-systems
#12
Sadrieh Hajesmaeel Gohari, Kambiz Bahaadinbeigy
BACKGROUND: This project sought to identify the most common telepathology consultation needs of pathologists based on the anatomic section of tissue to improve quality of consultations. METHODS: This cross-sectional study used a questionnaire with four questions to assess pathologists' consultation needs. The questionnaire was distributed to the 16 pathologists recruited for this study. All 16 of the pathologists work in Kerman province, the largest province of Iran, which is situated 1,000 kilometers from Tehran, Iran's capital city...
July 16, 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/27601805/current-status-and-future-trends-in-telepathology-and-digital-pathology
#13
Trupti Dinesh Chordia, Ashok Vikey, Anuraag B Choudhary, Yashpal Samdariya, Dipti Samdariya Chordia
OBJECTIVE: The purpose of this study was to assess the current status and future trends in telepathology (TP) and digital pathology (DP) in central India. MATERIALS AND METHODS: A self-constructed questionnaire including 12 questions was designed with five specialists, to improve the design ambiguity. The study was conducted through postal and online survey consisting of 12 questions and sent to 300 histopathologists. RESULTS: A total of 247 histopathologists answered the survey...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27563489/comparing-whole-slide-digital-images-versus-traditional-glass-slides-in-the-detection-of-common-microscopic-features-seen-in-dermatitis
#14
Nikki S Vyas, Michael Markow, Carlos Prieto-Granada, Sudeep Gaudi, Leslie Turner, Paul Rodriguez-Waitkus, Jane L Messina, Drazen M Jukic
BACKGROUND: The quality and limitations of digital slides are not fully known. We aimed to estimate intrapathologist discrepancy in detecting specific microscopic features on glass slides and digital slides created by scanning at ×20. METHODS: Hematoxylin and eosin and periodic acid-Schiff glass slides were digitized using the Mirax Scan (Carl Zeiss Inc., Germany). Six pathologists assessed 50-71 digital slides. We recorded objective magnification, total time, and detection of the following: Mast cells; eosinophils; plasma cells; pigmented macrophages; melanin in the epidermis; fungal bodies; neutrophils; civatte bodies; parakeratosis; and sebocytes...
2016: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/27471996/molecular-digital-pathology-progress-and-potential-of-exchanging-molecular-data
#15
Somak Roy, John D Pfeifer, William A LaFramboise, Liron Pantanowitz
Many of the demands to perform next generation sequencing (NGS) in the clinical laboratory can be resolved using the principles of telepathology. Molecular telepathology can allow facilities to outsource all or a portion of their NGS operation such as cloud computing, bioinformatics pipelines, variant data management, and knowledge curation. Clinical pathology laboratories can electronically share diverse types of molecular data with reference laboratories, technology service providers, and/or regulatory agencies...
September 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27423409/image-analysis-and-machine-learning-in-digital-pathology-challenges-and-opportunities
#16
EDITORIAL
Anant Madabhushi, George Lee
With the rise in whole slide scanner technology, large numbers of tissue slides are being scanned and represented and archived digitally. While digital pathology has substantial implications for telepathology, second opinions, and education there are also huge research opportunities in image computing with this new source of "big data". It is well known that there is fundamental prognostic data embedded in pathology images. The ability to mine "sub-visual" image features from digital pathology slide images, features that may not be visually discernible by a pathologist, offers the opportunity for better quantitative modeling of disease appearance and hence possibly improved prediction of disease aggressiveness and patient outcome...
October 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27420575/emerging-themes-in-image-informatics-and-molecular-analysis-for-digital-pathology
#17
Rohit Bhargava, Anant Madabhushi
Pathology is essential for research in disease and development, as well as for clinical decision making. For more than 100 years, pathology practice has involved analyzing images of stained, thin tissue sections by a trained human using an optical microscope. Technological advances are now driving major changes in this paradigm toward digital pathology (DP). The digital transformation of pathology goes beyond recording, archiving, and retrieving images, providing new computational tools to inform better decision making for precision medicine...
July 11, 2016: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/27283459/color-calibration-and-fusion-of-lens-free-and-mobile-phone-microscopy-images-for-high-resolution-and-accurate-color-reproduction
#18
Yibo Zhang, Yichen Wu, Yun Zhang, Aydogan Ozcan
Lens-free holographic microscopy can achieve wide-field imaging in a cost-effective and field-portable setup, making it a promising technique for point-of-care and telepathology applications. However, due to relatively narrow-band sources used in holographic microscopy, conventional colorization methods that use images reconstructed at discrete wavelengths, corresponding to e.g., red (R), green (G) and blue (B) channels, are subject to color artifacts. Furthermore, these existing RGB colorization methods do not match the chromatic perception of human vision...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27217976/evaluation-of-panoramic-digital-images-using-panoptiq-for-frozen-section-diagnosis
#19
Dinesh Pradhan, Sara E Monaco, Anil V Parwani, Ishtiaque Ahmed, Jon Duboy, Liron Pantanowitz
INTRODUCTION: Whole slide imaging (WSI) permits intraoperative consultations (frozen sections) to be performed remotely. However, WSI files are large and can be problematic if there are tissue artifacts (e.g., tissue folds) or when slides are scanned without multiplanes (Z-stacks) to permit focusing. The Panoptiq dynamic imaging system allows users to create their own digital files that combine low power panoramic digital images with regions of interest that can be imaged using high power Z-stacks...
2016: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/27101287/international-telepathology-promises-and-pitfalls
#20
REVIEW
Navid Farahani, Michael Riben, Andrew J Evans, Liron Pantanowitz
Innovative technologies for digital imaging and telecommunications are changing the way we deliver health care. Telepathology collaborations are one example of how delivering remote pathology services to patients can benefit from leveraging this change. Over the years, several academic and commercial teleconsultation networks have been established. Herein, we review the landscape of these international telepathology efforts and highlight key supportive factors and potential barriers to successful cross-border collaborations...
2016: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
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