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Digital Pathology

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https://www.readbyqxmd.com/read/28214227/automated-breast-density-computation-in-digital-mammography-and-digital-breast-tomosynthesis-influence-on-mean-glandular-dose-and-birads-density-categorization
#1
Maria Castillo-García, Margarita Chevalier, Julia Garayoa, Alejandro Rodriguez-Ruiz, Diego García-Pinto, Julio Valverde
RATIONALE AND OBJECTIVES: The study aimed to compare the breast density estimates from two algorithms on full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) and to analyze the clinical implications. MATERIALS AND METHODS: We selected 561 FFDM and DBT examinations from patients without breast pathologies. Two versions of a commercial software (Quantra 2D and Quantra 3D) calculated the volumetric breast density automatically in FFDM and DBT, respectively...
February 14, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28212555/construction-of-a-pathological-risk-model-of-occult-lymph-node-metastases-for-prognostication-by-semi-automated-image-analysis-of-tumor-budding-in-early-stage-oral-squamous-cell-carcinoma
#2
Nicklas Juel Pedersen, David Hebbelstrup Jensen, Giedrius Lelkaitis, Katalin Kiss, Birgitte Charabi, Lena Specht, Christian von Buchwald
It is challenging to identify at diagnosis those patients with early oral squamous cell carcinoma (OSCC), who have a poor prognosis and those that have a high risk of harboring occult lymph node metastases. The aim of this study was to develop a standardized and objective digital scoring method to evaluate the predictive value of tumor budding. We developed a semi-automated image-analysis algorithm, Digital Tumor Bud Count (DTBC), to evaluate tumor budding. The algorithm was tested in 222 consecutive patients with early-stage OSCC and major endpoints were overall (OS) and progression free survival (PFS)...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28203512/unusual-volar-pulp-location-of-glomus-tumor
#3
Ian A Rosner, Anne E Argenta, Kia M Washington
Glomus tumors are benign, painful growths originating from glomus bodies and comprise just 1% of tumors arising in the hand, with fewer than 10% in the volar pulp of digits. Hallmark symptoms of glomus tumors include hypersensitivity to cold, heightened pinprick sensitivity, and paroxysmal pain. We report a 72-year-old, right-hand dominant man who presented with pain in the left middle finger, localized to the tip. The fingertip was incredibly sensitive to touch, and his pain increased at night. He reported no recollection of trauma...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28193205/comparison-of-immunohistochemistry-with-pcr-for-assessment-of-er-pr-and-ki-67-and-prediction-of-pathological-complete-response-in-breast-cancer
#4
Hans-Peter Sinn, Andreas Schneeweiss, Marius Keller, Kornelia Schlombs, Mark Laible, Julia Seitz, Sotirios Lakis, Elke Veltrup, Peter Altevogt, Sebastian Eidt, Ralph M Wirtz, Frederik Marmé
BACKGROUND: Proliferation may predict response to neoadjuvant therapy of breast cancer and is commonly assessed by manual scoring of slides stained by immunohistochemistry (IHC) for Ki-67 similar to ER and PgR. This method carries significant intra- and inter-observer variability. Automatic scoring of Ki-67 with digital image analysis (qIHC) or assessment of MKI67 gene expression with RT-qPCR may improve diagnostic accuracy. METHODS: Ki-67 IHC visual assessment was compared to the IHC nuclear tool (AperioTM) on core biopsies from a randomized neoadjuvant clinical trial...
February 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28193010/variations-in-the-abundance-of-lipid-biomarker-ions-in-mass-spectrometry-images-correlate-to-tissue-density
#5
Jade Bilkey, Alessandra Tata, Trevor D McKee, Andreia M Porcari, Emma Bluemke, Michael Woolman, Manuela Ventura, Marcos N Eberlin, Arash Zarrine-Afsar
While mass spectrometry (MS) imaging is widely used to investigate the molecular composition of ex vivo slices of cancerous tumors, little is known about how variations in the cellular properties of cancer tissue can influence cancer biomarker ion images. To better understand the basis for variations in the abundances of cancer biomarker ions seen in MS images of relatively homogeneous ex vivo tumor samples, sections of snap frozen human breast cancer murine xenografts were subjected to desorption electrospray ionization mass spectrometry (DESI-MS) imaging...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28188419/angiographic-doughnut-shaped-aneurysm-of-intracranial-internal-carotid-artery
#6
Chung-Hsin Lee, Chih-Hsiang Liao, Wen-Hsien Chen, Hsu-Tung Lee, Yuang-Seng Tsuei
Morphologic characteristics of angiographic doughnut-shaped aneurysms of the intracranial internal carotid artery (ICA) have been rarely reported in the literature and were discussed only radiologically. In this case, surgical clipping was performed, and the specimen from the aneurysm was examined to correlate the pathologic findings and morphologic characteristics. A 59-year-old male presented with diffuse subarachnoid hemorrhage secondary to a ruptured vascular lesion originating from the intracranial portion of the right ICA...
February 10, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28185980/a-new-quantitative-measure-of-disc-degeneration
#7
Tapio Videman, Michele C Battié, Laura E Gibbons, Kevin Gill
BACKGROUND CONTEXT: The ability to adequately measure a phenomenon is critical to studying and understanding it. Since 1957, a variety of subjective visual grading methods have been used to assess disc degeneration, but have been limited by gross ordinal scales and imprecision, as well as suboptimal reliability. Conceptually sound, objective, precise measurements are needed to advance knowledge of disc degeneration and its causes, progression and consequences. PURPOSE: To investigate the reliability and validity of a new system ('SpIn' for Spine Insight) to quantitatively measure lumbar disc degeneration or pathology...
February 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28185408/full-field-digital-mammography-is-the-apparent-increased-detection-of-microcalcification-leading-to-over-investigation-and-over-diagnosis
#8
Alan J Porter, Elizabeth B Evans, Lisa M Erzetich
INTRODUCTION: Modern full-field digital mammography (FFDM) appears to have increased the detection of breast microcalcification. This retrospective study aimed to assess whether this is associated with over-investigation and possible over-diagnosis of breast pathology of lesser significance. METHODS: Three 2-year periods were studied, in which different mammographic technologies were used exclusively viz., classical screen-film mammography (SFM) in 2003-04, computed radiography (CR) in 2009-10 and FFDM in 2012-13...
February 9, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28179316/correlation-of-blood-t-cells-to-intratumoural-density-and-location-of-cd3-and-cd8-t-cells-in-colorectal-cancer
#9
Hanne R Hagland, Dordi Lea, Martin M Watson, Kjetil Søreide
AIM: To test the feasibility of conducting parallel analyses of circulating T-cells in blood and intratumoural T-cells in colorectal cancer. A pre-operative 'liquid biopsy' to determine immune status would facilitate clinical decision-making. MATERIALS AND METHODS: A total of 18 patients with stage I-III colorectal cancer (CRC) were included. Blood was analyzed for T-cell type (CD3(+), CD4(+) and CD8(+)) and count using flow cytometry. Intratumoural T-cells were stained using immunohistochemistry and quantified by digital pathology...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28179286/italian-prostate-biopsies-group-2016-updated-guidelines-insights
#10
REVIEW
Andrea Fandella, Vincenzo Scattoni, Andrea Galosi, Pietro Pepe, Michelangelo Fiorentino, Caterina Gaudiano, Marco Giampaoli, Roberta Gunelli, Pasquale Martino, Vittorino Montanaro, Rodolfo Montironi, Tiziana Pierangeli, Armando Stabile, Alessandro Bertaccini
AIM: To present a summary of the updated guidelines of the Italian Prostate Biopsies Group following the best recent evidence of the literature. MATERIALS AND METHODS: A systematic review of the new data emerging from 2012-2015 was performed by a panel of 14 selected Italian experts in urology, pathology and radiology. The experts collected articles published in the English-language literature by performing a search using Medline, EMBASE and the Cochrane Library database...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28174676/a-digital-staining-algorithm-for-optical-coherence-tomography-images-of-the-optic-nerve-head
#11
Jean-Martial Mari, Tin Aung, Ching-Yu Cheng, Nicholas G Strouthidis, Michaël J A Girard
PURPOSE: To digitally stain spectral-domain optical coherence tomography (OCT) images of the optic nerve head (ONH), and highlight either connective or neural tissues. METHODS: OCT volumes of the ONH were acquired from one eye of 10 healthy subjects. We processed all volumes with adaptive compensation to remove shadows and enhance deep tissue visibility. For each ONH, we identified the four most dissimilar pixel-intensity histograms, each of which was assumed to represent a tissue group...
February 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28168617/an-anatomical-study-of-pneumatized-crista-galli
#12
Ranko Mladina, Romano Antunović, Cemal Cingi, Nuray Bayar Muluk, Neven Skitarelić, Mislav Malić
The literature data on the incidence of pneumatization of the crista galli based on patients' computed tomography (CT) scans ranges from 3 to 37.5%. This study investigated for the first time the incidence of crista galli pneumatization based on CT scans of human skulls. The study examined 102 randomly selected human skulls (≥20 years of age; 76 males, 26 females). Skulls were scanned in a fixed position using cone beam computed tomography (CBCT) with a field of view of 145 × 130 mm and an isotropic voxel size of 0...
February 6, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28162815/improving-the-rotterdam-european-randomized-study-of-screening-for-prostate-cancer-risk-calculator-for-initial-prostate-biopsy-by-incorporating-the-2014-international-society-of-urological-pathology-gleason-grading-and-cribriform-growth
#13
Monique J Roobol, Jan F M Verbeek, Theo van der Kwast, Intan P Kümmerlin, Charlotte F Kweldam, Geert J L H van Leenders
BACKGROUND: The survival rate for men with International Society of Urological Pathology (ISUP) grade 2 prostate cancer (PCa) without invasive cribriform (CR) and intraductal carcinoma (IDC) is similar to that for ISUP grade 1. If updated into the European Randomized Study of Screening for Prostate Cancer (ERSPC Rotterdam) risk calculator number 3 (RC3), this may further improve upfront selection of men who need a biopsy. OBJECTIVE: To improve the number of possible biopsies avoided, while limiting undiagnosed clinically important PCa by applying the updated RC3 for risk-based patient selection...
February 2, 2017: European Urology
https://www.readbyqxmd.com/read/28157405/an-assessment-of-pathology-resident-access-to-and-use-of-technology-a-nationwide-survey
#14
Bethany D Vallangeon, Jeffrey S Hawley, Richard Sloane, Sarah M Bean
CONTEXT: -Current technologies including digital slide scanners and handheld devices can revolutionize clinical practice and pathology graduate medical education (GME). The extent to which these technologies are used in pathology GME is unknown. OBJECTIVES: -To determine the types of technologies used, usage amount, and how they are integrated into pathology residency/fellowship programs nationwide. DESIGN: -A 40-question online survey for residents/fellows was developed and administered via the Research Electronic Data Capture System after institutional review board approval...
February 3, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28157404/whole-slide-imaging-for-analytical-anatomic-pathology-and-telepathology-practical-applications-today-promises-and-perils
#15
Alton Brad Farris, Cynthia Cohen, Thomas E Rogers, Geoffrey H Smith
Whole slide imaging (WSI) offers a convenient, tractable platform for measuring features of routine and special-stain histology or in immunohistochemistry staining by using digital image analysis (IA). We now routinely use IA for quantitative and qualitative analysis of theranostic markers such as human epidermal growth factor 2 (HER2/neu), estrogen and progesterone receptors, and Ki-67. Quantitative IA requires extensive validation, however, and may not always be the best approach, with pancreatic neuroendocrine tumors being one example in which a semiautomated approach may be preferable for patient care...
February 3, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28153429/patients-with-benign-hand-tumors-are-indicated-for-surgery-according-to-patient-rated-outcome-measures
#16
Michiro Yamamoto, Tadahiro Natsume, Shigeru Kurimoto, Katsuyuki Iwatsuki, Takanobu Nishizuka, Michael T Nolte, Hitoshi Hirata
INTRODUCTION: This study assessed the treatment outcomes of upper extremity benign tumors using the patient-rated outcome measures of Hand20 questionnaire. METHODS: In total, 304 patients who underwent surgery for benign bone and soft tissue tumors of the upper limb were included. Tumors were classified into three size groups: <1 cm, 1-3 cm, and >3 cm. Tumors were divided with respect to location: digit, hand, wrist, forearm, elbow, upper arm, or axilla...
January 9, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28152853/oncologists-opinions-and-experiences-with-electronic-release-of-radiology-and-pathology-results-to-patients
#17
Farnoosh Sheikhi, Eben Lloyd Rosenthal, Christopher Sharp, Mark K Buyyounouski, Steve Asch
: 162 Background: There is an emerging standard to provide patients rapid electronic access to elements of their medical records,; this practice is controversial among practicing oncologists. Previous studies have primarily reported on patient access to physician notes and lab tests in primary care. In oncology, the emotional import and complexity of the results may be greater, particularly for staging imaging and biopsies. We report the opinions and experiences of oncologists after enabling patient access to radiology and pathology results for four months during which time finalized results were released upon physician action or after seven days...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28150025/initial-field-test-of-a-cloud-based-cardiac-auscultation-system-to-determine-murmur-etiology-in-rural-china
#18
Lee Pyles, Pouya Hemmati, J Pan, Xiaoju Yu, Ke Liu, Jing Wang, Andreas Tsakistos, Bistra Zheleva, Weiguang Shao, Quan Ni
A system for collection, distribution, and long distant, asynchronous interpretation of cardiac auscultation has been developed and field-tested in rural China. We initiated a proof-of-concept test as a critical component of design of a system to allow rural physicians with little experience in evaluation of congenital heart disease (CHD) to obtain assistance in diagnosis and management of children with significant heart disease. The project tested the hypothesis that acceptable screening of heart murmurs could be accomplished using a digital stethoscope and internet cloud transmittal to deliver phonocardiograms to an experienced observer...
February 2, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28138792/unusual-pattern-of-the-first-dorsal-metacarpal-artery
#19
Homero Bianchi, Diego Saravia, Nicolas Ernesto Ottone
This report describes an unusual pattern of the first dorsal metacarpal artery (FDMA) regarding its course and termination. This FDMA had an abnormal course, passing deep to various anatomical elements related to the index finger, with unusual termination in the radial and ulnar proper palmar digital arteries feeding the second and third fingers, respectively. There is no mention of this anatomical variation in the literature. We report the possible embryological origin of this case and other variations related to the FDMA...
January 30, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28138402/construction-and-analysis-of-tissue-microarrays-in-the-era-of-digital-pathology-a-pilot-study-targeting-cdx1-and-cdx2-in-a-colon-cancer-cohort-of-612-patients
#20
Sarah Nolte, Inti Zlobec, Alessandro Lugli, Werner Hohenberger, Roland Croner, Susanne Merkel, Arndt Hartmann, Carol I Geppert, Tilman T Rau
CDX1 and CDX2 are possibly predictive biomarkers in colorectal cancer. We combined digitally-guided (next generation) TMA construction (ngTMA) and the utility of digital image analysis (DIA) to assess accuracy, tumour heterogeneity and the selective impact of different combined intensity-percentage levels on prognosis.CDX1 and CDX2 immunohistochemistry was performed on ngTMAs covering normal tissue, tumour centre and invasive front. The percentages of all epithelial cells per staining intensity per core were analysed digitally...
January 2017: Journal of Pathology. Clinical Research
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