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Digital Pathology

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https://www.readbyqxmd.com/read/29457738/reproducibility-and-feasibility-of-strategies-for-morphologic-assessment-of-renal-biopsies-using-the-nephrotic-syndrome-study-network-digital-pathology-scoring-system
#1
Jarcy Zee, Jeffrey B Hodgin, Laura H Mariani, Joseph P Gaut, Matthew B Palmer, Serena M Bagnasco, Avi Z Rosenberg, Stephen M Hewitt, Lawrence B Holzman, Brenda W Gillespie, Laura Barisoni
CONTEXT: - Testing reproducibility is critical for the development of methodologies for morphologic assessment. Our previous study using the descriptor-based Nephrotic Syndrome Study Network Digital Pathology Scoring System (NDPSS) on glomerular images revealed variable reproducibility. OBJECTIVE: - To test reproducibility and feasibility of alternative scoring strategies for digital morphologic assessment of glomeruli and explore use of alternative agreement statistics...
February 19, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29456640/comparative-study-of-ultrasonic-elastography-and-conventional-ultrasound-in-diagnosis-of-malignant-anus-neoplasm
#2
Yicheng Zhu, Shuhao Deng, Yuan Zhang, Quan Jiang
The application value of conventional ultrasound and ultrasonic elastography (UE) in preoperative diagnosis and combined diagnosis of malignant anus neoplasms was investigated. One hundred and twenty patients, whose mass was detected by digital rectal examination, were examined using UE and conventional ultrasound before operation, and the results were compared with those of histopathological examinations after operation, so that the accuracy and imaging features of UE as well as UE combined with conventional ultrasound in diagnosing malignant anus neoplasm were analyzed...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29454754/mutational-analysis-of-akt1-and-pik3ca-in-intraductal-papillomas-of-the-breast-with-special-reference-to-cellular-components
#3
Chieko Mishima, Naofumi Kagara, Jun-Ichiro Ikeda, Eiichi Morii, Tomohiro Miyake, Tomonori Tanei, Yasuto Naoi, Masafumi Shimoda, Kenzo Shimazu, Seung Jin Kim, Shinzaburo Noguchi
The pathological feature of intraductal papillomas is defined as a papillary structure composed of a fibrovascular stromal core lined by luminal epithelial cells and myoepithelial cells. We used droplet digital PCR for the mutational analysis of AKT1 (E17K) and PIK3CA (H1047R, E542K, and E545K) in 60 papillomas. AKT1 and PIK3CA mutations were detected in 12 (20%) and 17 (28%) of the papillomas, respectively. In five tumors harboring mutations, mutational analysis of AKT1 or PIK3CA was performed separately using luminal epithelial cells and myoepithelial cells sorted using anti-CK19 antibody and anti-SMA antibody...
February 15, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29453523/digital-versus-light-microscopy-assessment-of-surgical-margin-status-after-radical-prostatectomy
#4
Metka Volavšek, Ana Blanca, Rodolfo Montironi, Liang Cheng, Maria R Raspollini, Nuno Vau, Jorge Fonseca, Francesco Pierconti, Antonio Lopez-Beltran
Positive surgical margin (PSM) extension reported as focal or non-focal/extensive is an important pathologic prognostic parameter after radical prostatectomy. Likewise, there is limited or no agreement on how to measure and what the best cut-off points to be used in practice are. We hypothesized that digital microscopy (DM) would potentially provide a more objective way to measure PSM and better define its clinical significance. To further our knowledge, we have evaluated PSM status in 107 laparoscopic radical prostatectomies using digital and conventional light microscopy (LM)...
February 16, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29452345/daily-biopsy-diagnosis-in-surgical-pathology-concordance-between-light-microscopy-and-whole-slide-imaging-in-real-life-conditions
#5
Irène Villa, Marie-Christine Mathieu, Jacques Bosq, Anne Auperin, Jean-François Pomerol, Magali Lacroix-Triki, Jean-Yves Scoazec, Peggy Dartigues
Objectives: The current challenge for the various digital whole-slide imaging (WSI) systems is to be definitively validated for diagnostic purposes. We designed a concordance study between glass slide and digital slide diagnosis in real-life conditions, coupled with an ergonomic study. Methods: Three senior pathologists evaluated, first in glass slides and then in digital slides, 119 biopsy cases, including 749 slides, with 332 H&E saffron stains and 417 additional techniques, mainly immunohistochemistry...
February 14, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29446263/pulsed-terahertz-imaging-of-breast-cancer-in-freshly-excised-murine-tumors
#6
Tyler Bowman, Tanny Chavez, Kamrul Khan, Jingxian Wu, Avishek Chakraborty, Narasimhan Rajaram, Keith Bailey, Magda El-Shenawee
This paper investigates terahertz (THz) imaging and classification of freshly excised murine xenograft breast cancer tumors. These tumors are grown via injection of E0771 breast adenocarcinoma cells into the flank of mice maintained on high-fat diet. Within 1 h of excision, the tumor and adjacent tissues are imaged using a pulsed THz system in the reflection mode. The THz images are classified using a statistical Bayesian mixture model with unsupervised and supervised approaches. Correlation with digitized pathology images is conducted using classification images assigned by a modal class decision rule...
February 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29444388/the-virtual-microscopy-database-sharing-digital-microscope-images-for-research-and-education
#7
Lisa M J Lee, Haviva M Goldman, Michael Hortsch
Over the last 20 years, virtual microscopy has become the predominant modus of teaching the structural organization of cells, tissues, and organs, replacing the use of optical microscopes and glass slides in a traditional histology or pathology laboratory setting. Although virtual microscopy image files can easily be duplicated, creating them requires not only quality histological glass slides but also an expensive whole slide microscopic scanner and massive data storage devices. These resources are not available to all educators and researchers, especially at new institutions in developing countries...
February 14, 2018: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29443359/validity-of-the-red-reflex-exam-in-the-newborn-eye-screening-test-cohort
#8
Cassie A Ludwig, Natalia F Callaway, Mark S Blumenkranz, Douglas R Fredrick, Darius M Moshfeghi
BACKGROUND AND OBJECTIVE: The validity of the red reflex exam has yet to be tested against new methods of wide-angle imaging that may improve early detection of neonatal ocular pathology. The authors aimed to determine the validity of the pediatrician's red reflex exam using 130° wide-angle external and fundus digital imaging as a gold standard. PATIENTS AND METHODS: This was a prospective cohort study of 194 healthy, term newborns enrolled in the Newborn Eye Screening Test study at Lucile Packard Children's Hospital from July 25, 2013, to July 25, 2014...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29442350/occult-phosphaturic-mesenchymal-tumor-of-femur-cortex-causing-oncogenic-osteomalacia-diagnostic-challenges-and-clinical-outcomes
#9
Deep Dutta, Raghuvansh Kumar Pandey, Rakhee Gogoi, Nagender Solanki, Renu Madan, Anupam Mondal, Shruti Dogra, Pradeep Thapa
BACKGROUND: Tumor induced osteomalacia (TIO) are extremely rare paraneoplastic syndrome with less than 300 reported cases. This report highlights the pitfalls and challenges in diagnosing and localizing TIO in patients with refractory and resistant osteomalacia. PATIENT AND METHODS: 41- year gentleman with 4-year history of musculoskeletal weakness and pathologic fractures presented in wheelchair bound incapacitated state of 1-year duration. Investigations were significant for severe hypophosphatemia, severe phosphaturia, normal serum calcium, reduced 1,25-dihydroxy vitamin-D, elevated ALP, elevated intact parathyroid hormone (iPTH), and pseudo-fractures involving pelvis and bilateral femur...
February 14, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29440134/interobserver-variation-in-the-diagnosis-of-fibroepithelial-lesions-of-the-breast-a-multicentre-audit-by-digital-pathology
#10
Benjamin F Dessauvagie, Andrew H S Lee, Katie Meehan, Anju Nijhawan, Puay Hoon Tan, Jeremy Thomas, Bibiana Tie, Darren Treanor, Seemeen Umar, Andrew M Hanby, Rebecca Millican-Slater
AIM: Fibroepithelial lesions (FELs) of the breast span a morphological continuum including lesions where distinction between cellular fibroadenoma (FA) and benign phyllodes tumour (PT) is difficult. The distinction is clinically important with FAs managed conservatively while equivocal lesions and PTs are managed with surgery. We sought to audit core biopsy diagnoses of equivocal FELs by digital pathology and to investigate whether digital point counting is useful in clarifying FEL diagnoses...
February 13, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29438166/noninferiority-diagnostic-value-but-also-economic-and-turnaround-time-advantages-from-digital-pathology
#11
Anna Vergani, Barbara Regis, Genny Jocollé, Roberta Patetta, Giulio Rossi
No abstract text is available yet for this article.
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29437039/microrna-1246-is-an-exosomal-biomarker-for-aggressive-prostate-cancer
#12
Divya Bhagirath, Thao Ly Yang, Nathan Bucay, Kirandeep Sekhon, Shahana Majid, Varahram Shahryari, Rajvir Dahiya, Yuichiro Tanaka, Sharanjot Saini
Due to high heterogeneity, molecular characterization of prostate cancer (PCa) based on biopsy sampling is often challenging. Hence, a minimally invasive method to determine the molecular imprints of a patient's tumor for risk stratification would be advantageous. In this study, we employ a novel, digital amplification-free quantification method using the nCounter technology (Nanostring Technologies) to profile exosomal serum miRNAs (ex-miRNA) from aggressive PCa cases, benign prostatic hyperplasia (BPH), and disease-free controls...
February 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/29429645/daytime-sleepiness-in-dementia-with-lewy-bodies-is-associated-with-neuronal-depletion-of-the-nucleus-basalis-of-meynert
#13
Koji Kasanuki, Tanis J Ferman, Melissa E Murray, Michael G Heckman, Otto Pedraza, Fadi S Hanna Al-Shaikh, Takayasu Mishima, Nancy N Diehl, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Neill R Graff-Radford, Dennis W Dickson
INTRODUCTION: Excessive daytime sleepiness is a commonly reported clinical feature of dementia with Lewy bodies (DLB) that can occur early in the disease. Cholinergic depletion is known to be severe in DLB, even when dementia severity is mild. The nucleus basalis of Meynert serves as a primary source of cortical acetylcholine, and has a role in facilitating cortical activation and arousal. We sought to determine whether daytime sleepiness at the initial evaluation of patients with DLB was associated with neuronal loss in the nucleus basalis of Meynert...
February 3, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29426360/not-all-false-positive-diagnoses-are-equal-on-the-prognostic-implications-of-false-positive-diagnoses-made-in-breast-mri-versus-in-mammography-digital-tomosynthesis-screening
#14
Christiane K Kuhl, Annika Keulers, Kevin Strobel, Hannah Schneider, Nadine Gaisa, Simone Schrading
BACKGROUND: Breast magnetic resonance imaging (MRI) has been reported to frequently result in false-positive diagnoses, limiting its positive predictive value (PPV). However, for PPV calculation, all nonmalignant tissue changes are equally considered false-positive, although the respective prognostic importance, and thus patient management implications, of different pathologies may well differ. We investigated the pathology of false-positive diagnoses made by MRI compared with radiographic (digital mammography/tomosynthesis [DM/DBT]) screening...
February 9, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29425983/primary-intracranial-angioleiomyomas-as-rare-nonmalignant-and-distinct-neoplastic-entities-a-series-of-8-cases-and-a-literature-review
#15
REVIEW
Cheng-Bei Li, Ming-Guo Xie, Jun-Peng Ma, Liang Wang, Shu-Yu Hao, Li-Wei Zhang, Wang Jia, Gui-Jun Jia, Jun-Ting Zhang, Da Li, Huan Li, Zhen Wu
OBJECTIVE: Primary intracranial angioleiomyoma is a rare and distinct neoplasm. Only 29 cases have been reported previously, and we aimed to investigate the clinical and radio-pathological features of these lesions. METHODS: Medical records and radiographs of 8 patients (7 male and 1 female; mean age: 48.7 years) at our institution were reviewed retrospectively. Patient follow-up and a literature review were performed. RESULTS: The most common preoperative symptom was a visual defect (n=2), followed by diplopia (n=1) and abducens paralysis (n=1)...
February 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29425225/an-integrated-strategy-for-improving-contrast-durability-and-portability-of-a-pocket-colposcope-for-cervical-cancer-screening-and-diagnosis
#16
Christopher T Lam, Jenna Mueller, Betsy Asma, Mercy Asiedu, Marlee S Krieger, Rhea Chitalia, Denali Dahl, Peyton Taylor, John W Schmitt, Nimmi Ramanujam
INTRODUCTION: We have previously developed a portable Pocket Colposcope for cervical cancer screening in resource-limited settings. In this manuscript we report two different strategies (cross-polarization and an integrated reflector) to improve image contrast levels achieved with the Pocket Colposcope and evaluate the merits of each strategy compared to a standard-of-care digital colposcope. The desired outcomes included reduced specular reflection (glare), increased illumination beam pattern uniformity, and reduced electrical power budget...
2018: PloS One
https://www.readbyqxmd.com/read/29424175/-experimental-study-on-staphylococcal-enterotoxin-promoting-tendon-bone-healing-after-reconstruction-of-anterior-cruciate-ligament-in-rabbits
#17
Chun-Bao Li, Chao Xue, Wei Qi, Ning Wang, Jing Xue, Xiao-Yong Wu, Juan-Li Zhu, Yang Liu, Yu-Jie Liu
OBJECTIVE: To explore highly agglutinative staphylococcin (HAS) pomoting on tendon-bone healing after reconstruction of anterior cruciate ligament(ACL) in rabbits. METHODS: Animal model of ACL reconstruction in 24 mature New Zealand white rabbits(3 months, 2.56 kg on average, either gender) were established using autologous digital long extensor tendon and randomly classified into 2 groups(HAS and control group), 12 rabbits for each group. HAS group was separately injected 0...
June 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29424129/micro-perfusion-and-quantitative-analysis-of-the-femoral-head-intraosseous-artery
#18
Xing Qiu, Liang-Liang Cheng, Ben-Jie Wang, Bao-Yi Liu, Lei Yang, Mingyang Yu, Guishan Gu, De-Wei Zhao
The present study investigates the feasibility of micro perfusion of femoral head specimens from femoral neck fracture patients by the inferior retinacular arteries and performing intraosseous artery quantitative analysis of the femoral head. Twelve femoral neck fracture patients who had undergone conventional hip replacement surgery were included in this study. Femoral head specimen arteries were first dissected and exposed and then perfused by the inferior retinacular arteries and all the femoral heads underwent micro-CT scanning...
February 9, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29411097/-big-data-in-imaging
#19
REVIEW
Philipp Sewerin, Benedikt Ostendorf, Axel J Hueber, Arnd Kleyer
Until now, most major medical advancements have been achieved through hypothesis-driven research within the scope of clinical trials. However, due to a multitude of variables, only a certain number of research questions could be addressed during a single study, thus rendering these studies expensive and time consuming. Big data acquisition enables a new data-based approach in which large volumes of data can be used to investigate all variables, thus opening new horizons. Due to universal digitalization of the data as well as ever-improving hard- and software solutions, imaging would appear to be predestined for such analyses...
February 6, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29410346/pathologic-upgrade-rates-of-high-risk-breast-lesions-on-digital-2-dimensional-vs-tomosynthesis-mammography
#20
Leslie R Lamb, Manisha Bahl, Kevin S Hughes, Constance D Lehman
BACKGROUND: To compare the pathologic upgrade rates of high-risk breast lesions (HRLs) on digital 2D mammography (DM) versus digital breast tomosynthesis (DBT). STUDY DESIGN: The study cohort was composed of patients with HRLs diagnosed by image-guided core needle biopsy from December 2007 to February 2011 (DM group, before DBT integration) and from January 2013 to March 2016 (DBT group, after complete DBT integration). Medical records were reviewed for surgical outcomes and follow-up imaging...
February 1, 2018: Journal of the American College of Surgeons
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