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Corneal cross-linking

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https://www.readbyqxmd.com/read/28922329/conventional-corneal-collagen-cross-linking-versus-transepithelial-diluted-alcohol-and-iontophoresis-assisted-corneal-cross-linking-in-progressive-keratoconus
#1
Kamil Bilgihan, Nilufer Yesilirmak, Yesim Altay, Armagan Yuvarlak, Huseyin Baran Ozdemir
PURPOSE: To compare clinical outcomes of conventional corneal cross-linking (C-CXL) and diluted alcohol and iontophoresis-assisted corneal cross-linking (DAI-CXL) for the treatment of progressive keratoconus (KC). METHODS: Ninety-three eyes of 80 patients with KC were treated by C-CXL (n = 47) or DAI-CXL (n = 46). Visual acuity, keratometry, KC indexes, pachymetry, and aberrations were recorded before treatment and 1, 3, 6, and 12 months after treatment. The demarcation line was assessed 1 month after treatment...
September 14, 2017: Cornea
https://www.readbyqxmd.com/read/28919243/drugs-do-we-need-them-applications-of-non-pharmaceutical-therapy-in-anterior-eye-disease-a-review
#2
REVIEW
Priyanka Mandal, Mohammad A Khan, Sunil Shah
Natural products have been in use long before the introduction of modern drug therapies and are still used in various communities worldwide for the treatment of anterior eye disease. The aim of this review is to look at the current non-pharmaceutical modalities that have been tried and assess the body of existing evidence behind them. This includes alternative medicine, existing non-pharmaceutical therapy and more recent low and high tech solutions. A detailed search of all available databases including MEDLINE, Pubmed and Google was made to look for English-language studies for complementary and alternative treatment modalities (CAM), natural therapies and new modalities for anterior eye disease such as blepharitis, dry eye and microbial keratitis...
September 14, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28913504/a-review-and-meta-analysis-of-corneal-cross-linking-for-post-laser-vision-correction-ectasia
#3
REVIEW
Qi Wan, Dan Wang, HongQuan Ye, Jing Tang, Yu Han
PURPOSE: The aim of this study was to review the safety and stability of cornea cross-linking (CXL) for the treatment of keratectasia after Excimer Laser Refractive Surgery. METHODS: Eligible studies were identified by systematically searching PubMed, Embase, Web of Science and reference lists. Meta-analysis was performed using Stata 12.1 software. The primary outcome parameters included the changes of corrected distant visual acuity (CDVA), uncorrected visual acuity (UCVA), the maximum keratometry value (Kmax) and minimum keratometry value (Kmin), the surface regularity index (SRI), the surface asymmetry index (SAI), the keratoconus prediction index (KPI), corneal thickness, and endothelial cell count...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28910157/photochemical-cross-linking-for-penetrating-corneal-wound-closure-in-enucleated-porcine-eyes
#4
Ti Wang, Lu Zhu, Yinbo Peng, Nianci Shen, Yan Yu, Min Yao, Jingyin Zhu
PURPOSE: To compare the efficacy of photochemical-induced tissue cross-linking (PCL), utilizing Rose Bengal (RB) and 532 nm green light irradiation (RB-PCL), with standard sutures for closure of penetrating corneal incision in porcine cadaver eyes. METHODS: A full-thickness penetrating incision, 3 mm in length parallel to the limbus and perpendicular to the corneal surface, was made in the enucleated porcine cornea. Photochemical cross-linking was performed with tropical RB application and irradiation of 532 nm green light (0...
September 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28905822/higher-order-aberration-4-years-after-corneal-collagen-cross-linking
#5
Mohammad Naderan, Ali Jahanrad
PURPOSE: Corneal collagen cross-linking (CXL) is a treatment strategy used in keratoconic eyes. Evaluation of long-term changes of higher-order aberrations (HOAs) after CXL is useful in understanding the efficacy of this procedure in improving optical, refractive, and visual acuity. This study aims to investigate the long-term effect of CXL on ocular HOA in patients with progressive keratoconus (KC). METHODS: Using an OPD-Scan II aberrometer, ocular HOAs measurements of 56 eyes of 56 patients that underwent CXL was evaluated at the baseline, 1, 2, and 4 years after the procedure...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905820/recent-advances-in-corneal-collagen-cross-linking
#6
REVIEW
Gitansha Shreyas Sachdev, Mahipal Sachdev
Corneal collagen cross-linking has become the preferred modality of treatment for corneal ectasia since its inception in late 1990s. Numerous studies have demonstrated the safety and efficacy of the conventional protocol. Our understanding of the cross-linking process is ever evolving, with its wide implications in the form of accelerated and pulsed protocols. Newer advancements in technology include various riboflavin formulations and the ability to deliver higher fluence protocols with customised irradiation patterns...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28902914/oxidative-stress-induces-dysregulated-autophagy-in-corneal-epithelium-of-keratoconus-patients
#7
Rohit Shetty, Anupam Sharma, Natasha Pahuja, Priyanka Chevour, Neeraja Padmajan, Kamesh Dhamodaran, Chaitra Jayadev, Rudy M M A Nuijts, Arkasubhra Ghosh, Jeyabalan Nallathambi
Oxidative stress is one of the key factors that contributes to the pathogenesis of keratoconus (KC). Macroautophagy is a vital cellular mechanism that is activated in response to oxidative stress. The aim of this study was to understand the role of the autophagic lysosomal pathway in the oxidative damage of KC corneal epithelium and the human corneal epithelial cell line (HCE).The corneal epithelium was collected from 78 KC patients undergoing corneal cross-linking or topography guided photorefractive keratectomy...
2017: PloS One
https://www.readbyqxmd.com/read/28898355/topical-cross-linked-ha-based-hydrogel-accelerates-closure-of-corneal-epithelial-defects-and-repair-of-stromal-ulceration-in-companion-animals
#8
David L Williams, Barbara M Wirostko, Glenwood Gum, Brenda K Mann
Purpose: The purpose of this study was to determine the safety of topical ocular administration of a cross-linked, modified hyaluronic acid (xCMHA-S) hydrogel, and its effectiveness in accelerating repair and closure of acute and nonhealing corneal ulcers in companion animals as a veterinary treatment and its utility as a model for therapy in human corneal ulceration. Methods: Two concentrations of xCMHA-S (0.33% and 0.75%) were topically administered to the eyes of rabbits six times daily for 28 days to assess safety...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28892949/corneal-collagen-cross-linking-for-treatment-of-bacterial-and-herpetic-keratitis
#9
Mohammad Reza Khalili, Hamid Reza Jahadi, Mashaallah Karimi, Masoud Yasemi
INTRODUCTION: Optimal management of infective keratitis is a formidable challenge and subject of ongoing studies. Recently, Collagen Cross-Linking (CXL) of the cornea has been considered to be a new effective therapeutic approach for resistant infectious keratitis. AIM: Aim of the study was to evaluate the effectiveness of CXL with Ultraviolet-A (UV-A) and riboflavin for treatment of the refractory bacterial and Herpes Simplex Virus (HSV) keratitis. MATERIALS AND METHODS: In this prospective interventional study, eight patients with diagnosis of infectious keratitis who were referred to Khalili Hospital eye emergency room, between 2014 and 2015 were included in the study...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28880336/toric-icl-implantation-after-sequential-intracorneal-ring-segments-implantation-and-corneal-cross-linking-in-keratoconus-2-year-follow-up
#10
Youssef Abdelmassih, Sylvain El-Khoury, Elias Chelala, Elise Slim, Carole G Cherfan, Elias Jarade
PURPOSE: To evaluate 6-month and 2-year safety and clinical outcomes of Visian toric Implantable Collamer Lens (toric ICL) (STAAR Surgical, Monrovia, CA) implantation for the treatment of residual refractive errors after sequential intracorneal ring segments (ICRS) insertion and cross-linking (CXL) in keratoconus. METHODS: This consecutive case series included the results of a three-step ICRS-CXL-toric ICL procedure in 16 eyes of 13 patients with moderate to severe keratoconus (stages II and III of Amsler-Krumeich classification)...
September 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28876968/corneal-collagen-cross-linking-complications
#11
Charisma B Evangelista, Kathryn M Hatch
Corneal cross-linking was approved by United States Food and Drug Administration for the treatment of progressive keratoconus in April 2016. As this approach becomes more widely used for the treatment of keratoconus and post-laser in situ keratomileusis (LASIK) ectasia, the medical community is becoming more familiar with potential complications associated with this procedure. This article aims to review the reported complications of collagen cross-linking for the treatment of keratoconus and post-LASIK ectasia...
September 6, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28872519/changes-in-corneal-density-after-accelerated-corneal-collagen-cross-linking-with-different-irradiation-intensities-and-energy-exposures-1-year-follow-up
#12
Semra Akkaya Turhan, Ebru Toker
PURPOSE: To determine and compare the changes in corneal density after 2 different protocols of accelerated corneal collagen cross-linking (A-CXL) in patients with progressive keratoconus. METHODS: Two groups of eyes received A-CXL treatment; 20 eyes received A-CXL using continuous UVA light exposure at 9 mW/cm for 10 minutes with a total energy dose of 5.4 J/cm, and 24 eyes received A-CXL using continuous UVA light exposure at 30 mW/cm for 4 minutes with a total energy dose of 7...
August 31, 2017: Cornea
https://www.readbyqxmd.com/read/28860694/evaluation-of-the-effect-of-corneal-collagen-cross-linking-for-keratoconus-on-the-ocular-higher-order-aberrations
#13
Ahmed Abdel-Karim El-Massry, Amgad Mostafa Dowidar, Tamer Hamdy Massoud, Baher Guirguis Daoud Tadros
BACKGROUND: Corneal collagen cross-linking (CXL) is the only treatment currently available to arrest the progression of keratoconus. The procedure consists of photopolymerization of stromal collagen fibers induced by combined action of a photosensitizing substance (riboflavin or vitamin B2) and ultraviolet-A light. PURPOSE: To determine changes in the ocular higher-order aberrations (HOAs) after CXL and its correlation with changes in visual acuity. DESIGN: Prospective interventional study...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28858045/corneal-hysteresis-is-reduced-in-obstructive-sleep-apnea-syndrome
#14
Suchitra Nadarajah, Amir Samsudin, Norlina Ramli, Chong Tin Tan, Zahari Mimiwati
SIGNIFICANCE: To our knowledge, this is the first time a study looking at the association between corneal hysteresis (CH) and obstructive sleep apnea syndrome (OSAS) severity has been reported. We provide evidence that CH is lower in OSAS and speculate on the possible causes. PURPOSE: The present study aims to look at the association between CH and severity of OSAS, and whether CH could be another link between OSAS and the development of glaucoma. METHODS: This was a cross-sectional, observational study at the University Malaya Medical Centre, Kuala Lumpur...
August 25, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28855517/cross-linked-decellularized-porcine-corneal-graft-for-treating-fungal-keratitis
#15
Yongliang Lin, Qinxiang Zheng, Shanshan Hua, Yongchun Meng, Wei Chen, Yifei Wang
This study aims to develop a cross-linked decellularized porcine corneal graft (cDPC) as a substitute for lamellar donor corneas and to evaluate the feasibility of using cDPC to treat fungal keratitis. The cDPC was prepared by decellularization, chemical crosslinking and γ-ray irradiation. Transparency, effectiveness of decellularization and biomechanical strength of cDPC were evaluated. The safety and efficacy of using cDPC to treat fungal keratitis were evaluated in the rabbit model. The transparency of cDPC was similar to that of a native porcine cornea (NPC), and no intact cells were observed in cDPC except for an insignificant amount of residual shrinking cellular nucleus...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28852910/pediatric-keratoconus-a-review-of-the-literature
#16
REVIEW
Sabrina Mukhtar, Balamurali K Ambati
PURPOSE: To describe the epidemiology and prevalence, rates of progression, difference between adult and pediatric populations, and therapeutic approaches to pediatric keratoconus from documented literature. METHODS: A literature search was done on PubMed using key words including pediatric keratoconus, children with keratoconus, adult keratoconus, penetrating keratoplasty, corneal cross-linking and intracorneal ring segments. The literature was reviewed and reported to explore the key epidemiological differences between the pediatric and adult population with regards to presentation and treatment options...
August 29, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28837530/visual-outcomes-after-smile-lasek-and-lasek-combined-with-corneal-cross-linking-for-high-myopic-correction
#17
Montserrat Garcia-Gonzalez, Miguel A Teus, Juan Gros-Otero
No abstract text is available yet for this article.
August 23, 2017: Cornea
https://www.readbyqxmd.com/read/28837529/corneal-tomographic-changes-after-uv-cross-linking-for-corneal-ectasia-1-year-results
#18
Zainab Baksoellah, Itay Lavy, Lamis Baydoun, Hilde C M Hooijmaijers, Korine van Dijk, Gerrit R J Melles
PURPOSE: To evaluate changes in maximum keratometry (Kmax), corneal higher-order aberrations (HOAs), and densitometry (backscattered light) up to 1 year after UV cross-linking and their possible relation with changes in the visual outcome. METHODS: Retrospective cohort study on 18 eyes of 16 patients, who underwent UV cross-linking after the Dresden protocol for progressive keratoconus or ectasia after laser-assisted in situ keratomileusis. Corrected distance visual acuity (CDVA), Scheimpflug-based corneal tomography, mean image brightness (corneal densitometry) from the anterior 120 μm of the midcornea, and posterior 60 μm of the central 6 mm of the cornea, and HOAs were evaluated...
August 23, 2017: Cornea
https://www.readbyqxmd.com/read/28828480/long-term-biomechanical-and-histologic-results-of-wst-d-nir-corneal-stiffening-in-rabbits-up-to-8-months-follow-up
#19
Jurriaan Brekelmans, Alexandra Goz, Mor M Dickman, Alexander Brandis, Xiaomeng Sui, H Daniel Wagner, Rudy M M A Nuijts, Avigdor Scherz, Arie L Marcovich
Purpose: To determine the long-term safety and efficacy of WST-D/near-infrared (NIR) corneal stiffening. Methods: One eye of 23 New Zealand White rabbits was de-epithelialized mechanically followed by topical application of 2.5 mg/mL WST11, combined with dextran-500 (WST-D) for 20 minutes. Subsequently, samples were irradiated with a NIR (755 nm) laser at 10 mW/cm2 for 30 minutes. Untreated fellow eyes served as controls. One week (n = 4), 1 month (n = 6), 4 months (n = 9), or 8 months (n = 4) after treatment rabbits were euthanized...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28811794/comparing-the-effects-of-two-different-contact-lenses-on-corneal-re-epithelialization-after-corneal-collagen-cross-linking
#20
Yusuf Kocluk, Savas Cetinkaya, Emine Alyamac Sukgen, Murat Günay, Alper Mete
OBJECTIVE: To investigate whether keratoconus (KC) patients who applied the corneal collagen cross-linking (CXL) and two different contact lens (CL) showed any differences in complaints and findings following the CXL. METHODS: This prospective, comparative, double-blind clinical study involved 60 eyes of 60 patients (38 female and 22 male). At the end of the CXL procedure, CL (Balafilcon A) was inserted in 29 patients (Group-1) while CL with different material content (Hioxifilcon A) designed for therapeutic/bandage purposes were inserted in 31 patients (Group-2)...
May 2017: Pakistan Journal of Medical Sciences Quarterly
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