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Corneal cross-linking

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https://www.readbyqxmd.com/read/28646439/alterations-in-contact-lens-fitting-parameters-following-cross-linking-in-keratoconus-patients-of-indian-ethnicity
#1
Kirti Singh, Mainak Bhattacharyya, Ritu Arora, Sonal Dangda, Ankush Mutreja
BACKGROUND: Most studies have either excluded patients using contact lens or not taken their effect while analyzing post-collagen cross-linkage (CXL) changes. This study aims to study impact of CXL on lens fit in both quantitative and qualitative manner. OBJECTIVE: To evaluate changes in CL fit post-CXL and to correlate these changes with alterations in corneal topographic parameters. STUDY DESIGN: Prospective intervention study on 20 keratoconic eyes of 14 patients (age > 18 years), with mean follow-up of 6 months...
June 23, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28644862/high-intensity-corneal-collagen-crosslinking-with-riboflavin-and-uva-in-rat-cornea
#2
Yirui Zhu, Peter S Reinach, Hanlei Zhu, Qiufan Tan, Qinxiang Zheng, Jia Qu, Wei Chen
Corneal collagen cross-linking (CXL) halts human corneal ectasias progression by increasing stromal mechanical stiffness. Although some reports describe that this procedure is effective in dealing with some infectious and immunologic corneal thinning diseases, there is a need for more animal models whose corneal thickness more closely resemble those occurring in these patients. To meet this need, we describe here high-intensity protocols that are safe and effective for obtaining CXL in rat corneas. Initially, a range of potentially effective UVA doses were evaluated based on their effectiveness in increasing tissue enzymatic resistance to dissolution...
2017: PloS One
https://www.readbyqxmd.com/read/28644681/treatment-results-of-corneal-collagen-cross-linking-combined-with-riboflavin-and-440-nm-blue-light-for-bacterial-corneal-ulcer-in-rabbits
#3
Shufang Wei, Cuiying Zhang, Shaoru Zhang, Yanyun Xu, Guoying Mu
PURPOSE: To study the treatment effect of corneal collagen cross-linking (CXL) combined with 440 nm blue light and riboflavin on bacterial corneal ulcer using animal experiments. METHODS: A total of 21 New Zealand white rabbits that developed Staphylococcus aureus corneal ulcer were randomly divided into three groups. Seven rabbits were used as blank control groups; seven rabbits were treated with CXL combined with riboflavin and 440 nm blue light; and seven rabbits were treated with CXL combined with riboflavin and 370 nm ultraviolet A light...
June 23, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28644240/corneal-stiffening-by-a-bacteriochlorophyll-derivative-with-dextran-and-near-infrared-light-effect-of-shortening-irradiation-time-up-to-1-minute
#4
Jurriaan Brekelmans, Alexandra Goz, Mor M Dickman, Alexander Brandis, Xiaomeng Sui, H Daniel Wagner, Rudy M M A Nuijts, Avigdor Scherz, Arie L Marcovich
PURPOSE: The aim of this study is to determine the effect of variation of the exposure time of near-infrared irradiation on corneal stiffening after a bacteriochlorophyll derivative (WST11) with dextran (WST-D) application. METHODS: One hundred four paired eyes of 3-month-old New Zealand White rabbits were included in this study. Fifty-two eyes (ex vivo n = 34, in vivo n = 18) were mechanically deepithelialized, treated topically with WST-D, and irradiated at 10 mW/cm using a diode laser at 755 nm for 1, 5, or 30 minutes...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28626821/mesopic-visual-quality-after-accelerated-corneal-cross-linking-a-12-month-follow-up-study
#5
Hassan Hashemi, Soheila Asgari
PURPOSE: To determine the 1-year changes of mesopic higher order aberrations (HOAs) and contrast sensitivity (CS) after accelerated corneal cross linking (CXL) in progressive keratoconus. METHODS: In this prospective case series, 70 eyes of 62 keratoconic patients underwent accelerated CXL (18 mW/cm(2), 5 min). HOAs and CS were measured using the OPD Scan III and CSV-1000 CS test charts under mesopic conditions before and 6 and 12 months after CXL. RESULTS: At 1 year, logarithmic mesopic CS in spatial frequencies of 3, 6, 12, and 18 cycles per degree (CPD) had increased by 0...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28611646/corneal-cross-linking-as-a-treatment-for-fungal-keratitis-associated-with-corneal-melting
#6
Vadim Igal, Yael Sara Pikkel Igal, Yoav Yechezkel Pikkel
We present the case of a young male that suffered from fungal corneal abscess and corneal melting. The patient was treated successfully by corneal cross-linking. Taking into account our experience from this case, we offer to consider corneal cross-linking as a therapeutic option in cases of fungal keratitis.
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28603017/effects-of-diabetes-mellitus-on-biomechanical-properties-of-the-rabbit-cornea
#7
FangJun Bao, ManLi Deng, XiaoBo Zheng, LinNa Li, YiPing Zhao, Si Cao, AYong Yu, QinMei Wang, JinHai Huang, Ahmed Elsheikh
To investigate the effects of diabetes on the biomechanical behavior of cornea in alloxan-induced diabetic rabbits. Diabetes mellitus (DM) was induced in 20 rabbits using alloxan, while another 20 age- and weight-matched non-diabetic rabbits served as controls. Eyes were enucleated after 8 weeks of inducing diabetes and the whole cornea was removed with a 3 mm wide scleral ring and tested under inflation conditions with an internal pressure range of 2.0-30.0 mmHg to determine their stress-strain behavior using an inverse analysis process...
June 8, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28592658/the-structural-response-of-the-cornea-to-changes-in-stromal-hydration
#8
Sally Hayes, Tomas White, Craig Boote, Christina S Kamma-Lorger, James Bell, Thomas Sorenson, Nick Terrill, Olga Shebanova, Keith M Meek
The primary aim of this study was to quantify the relationship between corneal structure and hydration in humans and pigs. X-ray scattering data were collected from human and porcine corneas equilibrated with polyethylene glycol (PEG) to varying levels of hydration, to obtain measurements of collagen fibril diameter, interfibrillar spacing (IFS) and intermolecular spacing. Both species showed a strong positive linear correlation between hydration and IFS(2) and a nonlinear, bi-phasic relationship between hydration and fibril diameter, whereby fibril diameter increased up to approximately physiological hydration, H = 3...
June 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28590790/the-effect-of-ascorbic-acid-vitamin-c-on-transepithelial-corneal-cross-linking-in-rabbits
#9
Mustafa Koc, Basak Bostanci, Ozlem Ozbas Demirel, Feyza Genc, Kemal Tekin, Yaran Koban, Aylin Sepici Dincel, Murat Sen, Pelin Yilmazbas
PURPOSE: To evaluate the effects of ascorbic acid (vitamin C), the main antioxidant agent in the cornea on transepithelial corneal cross-linking (CXL) where the main mechanism is oxidation. METHODS: Twenty eyes of 20 rabbits were divided into 3 groups: Group 1 (7 eyes) had transepithelial corneal CXL after being fed with normal diet; Group 2 (7 eyes) had corneal CXL after once-daily subcutaneous injections of 200 mg of ascorbic acid in addition to normal diet; and the control group (6 eyes) was fed with normal diet but did not have corneal CXL performed...
June 7, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28586502/biomechanical-changes-after-lasik-flap-creation-combined-with-rapid-cross-linking-measured-with-brillouin-microscopy
#10
J Bradley Randleman, Johnny P Su, Giuliano Scarcelli
PURPOSE: To evaluate the biomechanical changes occurring after LASIK flap creation and rapid corneal cross-linking (CXL) measured with Brillouin light microscopy. METHODS: Porcine eyes (n = 11) were evaluated by Brillouin light microscopy sequentially in the following order: virgin state, after LASIK flap creation, and after rapid CXL. Each eye served as its own control. Depth profile of the Brillouin frequency shift was computed to reveal the depth-dependent changes in corneal stiffness...
June 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28552439/sterile-infiltrates-after-cross-linking
#11
G García de Oteyza, J Álvarez de Toledo
CASE REPORT: A 20 year-old woman presented with an asymmetric bilateral keratoconus. Cross-linking of the right eye was performed due of its topographic and pachymetric conditions. Three days after the procedure, the patient presented with some corneal infiltrates that where classified as sterile. DISCUSSION: Cross-linking is known for its efficacy and safety. Nevertheless, there can be complications. Sterile infiltrates have already been described, although their aetiology is still not clear...
May 25, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28551428/delivery-of-riboflavin-5-monophosphate-into-the-cornea-can-liposomes-provide-any-enhancement-effects
#12
Neva Kandzija, Vitaliy V Khutoryanskiy
Keratoconus is a progressive condition caused by the thinning of the cornea, which eventually deforms the front surface of the eye into a cone shape leading to ghosting, multiple images, glare, and several other vision problems. Currently, keratoconus is treated with UV-induced riboflavin (Rb)-mediated collagen cross-linking, which requires a physical removal of the corneal epithelium under topical anesthesia. This study reports the penetration of Rb and its more water-soluble form, riboflavin-5'-monophosphate (RbP), into the bovine cornea ex vivo...
May 24, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28546941/role-of-corneal-collagen-fibrils-in-corneal-disorders-and-related-pathological-conditions
#13
REVIEW
Hong-Yan Zhou, Yan Cao, Jie Wu, Wen-Song Zhang
The cornea is a soft tissue located at the front of the eye with the principal function of transmitting and refracting light rays to precisely sense visual information. Corneal shape, refraction, and stromal stiffness are to a large part determined by corneal fibrils, the arrangements of which define the corneal cells and their functional behaviour. However, the modality and alignment of native corneal collagen lamellae are altered in various corneal pathological states such as infection, injury, keratoconus, corneal scar formation, and keratoprosthesis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546688/collagen-cross-linking-for-microbial-keratitis
#14
REVIEW
Prashant Garg, Sujata Das, Aravind Roy
Collagen cross-linking is gaining popularity not only for arresting the progression of keratoconus but also other indications including management of corneal infections. In this review article, we analyzed the published literature to understand the level of evidence for its use in corneal ulcer. Photoactivated riboflavin and ultraviolet A light are known to possess antimicrobial properties. The treatment also induces formation of inter- and intra-fibrillar bonds, thereby making the corneal collagen resistant to the action of proteases arresting stromal melt...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28540578/-complications-and-postoperative-therapeutic-strategies-in-cross-linking
#15
REVIEW
M Kohlhaas
CLINICAL ISSUE: The reduced corneal mechanical stability in keratoconus and similar collagen diseases can lead to a progressive and irregular corneal shape and decrease of visual acuity. DIAGNOSTICS: A progression of keratectatic diseases can be shown with corneal topography. TREATMENT: Keratoconus can be treated by photo-oxidative cross-linking of the corneal collagen. In order to achieve a high absorption of irradiation energy in the cornea, riboflavin at a concentration of 0...
May 24, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28513489/the-influence-of-corneal-collagen-cross-linking-on-anterior-chamber-in-keratoconus
#16
Nihat Polat, Abuzer Gunduz, Cemil Colak
AIMS: This study aimed to evaluate the effect of the corneal changes following corneal cross-linking (CXL) on the anterior chamber in keratoconus patients. MATERIALS AND METHODS: Forty-five eyes of 32 patients who had been diagnosed with progressive keratoconus and had undergone CXL were included in this retrospective study. The thinnest corneal thickness of the progressive keratoconus patients included in the study was >400 μ. The preoperative (T0), postoperative 6th month (T1), and postoperative 1st year (T2) anterior chamber volume (ACV), anterior chamber angle (ACA), and anterior chamber depth (ACD) scheimpflug imaging values were obtained for each eye...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28503442/clinical-outcomes-at-one-year-following-keratoconus-treatment-with-accelerated-transepithelial-cross-linking
#17
Alberto Artola, David P Piñero, Pedro Ruiz-Fortes, Roberto Soto-Negro, Rafael J Pérez-Cambrodí
This study evaluated the clinical outcomes in keratoconus corneas following accelerated transepithelial corneal collagen cross-linking (CXL) (Avedro KXL(®) system, Waltham, MA, USA) over one year of follow-up. The mean depth of the demarcation line measured by optical coherence tomography (OCT) was 205.19 µm. One month after surgery, a non-statistically significant change was noted in sphere (P=0.18) and in spherical equivalent (P=0.17), whereas a significant improvement was observed in corrected distance visual acuity (P=0...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28486719/customized-topography-guided-corneal-collagen-cross-linking-for-keratoconus
#18
Myriam Cassagne, Kévin Pierné, Stéphane D Galiacy, Marie-Pierre Asfaux-Marfaing, Pierre Fournié, François Malecaze
PURPOSE: To compare the efficacy and safety of topography-guided corneal collagen cross-linking (TG-CXL) to conventional corneal CXL (C-CXL) in progressive keratoconus. METHODS: In this prospective, nonrandomized clinical trial, 60 eyes of 60 patients were scheduled to receive either TG-CXL (30 eyes with deepithelialization focused on the cone, riboflavin application for 10 minutes, and 30 mW/cm(2) pulsed ultraviolet-A irradiance pattern according to topography) or C-CXL (30 eyes treated in accordance with the Dresden protocol)...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28486315/comparison-of-2-different-methods-of-transepithelial-corneal-collagen-cross-linking-analysis-of-corneal-histology-and-hysteresis
#19
Young Min Park, Ho Yoon Kim, Jong Soo Lee
PURPOSE: To compare the effect of 2 different methods of transepithelial corneal collagen cross-linking (CXL) on corneal histology and hysteresis. METHODS: The right eyes of New Zealand white rabbits (n = 50) were treated using one of the 2 transepithelial CXL methods. The eyes were then divided into 2 groups: group 1, transepithelial CXL using continuous ultraviolet A (UVA); group 2, accelerated transepithelial CXL using pulsed UVA. RESULTS: Both groups showed a postoperative increase in central corneal thickness...
July 2017: Cornea
https://www.readbyqxmd.com/read/28486312/biomechanical-and-histopathologic-effects-of-pulsed-light-accelerated-epithelium-on-off-corneal-collagen-cross-linking
#20
Xiaoyu Zhang, Ling Sun, Yang Shen, Mi Tian, Jing Zhao, Yu Zhao, Meiyan Li, Xingtao Zhou
PURPOSE: This study aimed to compare the biomechanical and histopathologic effects of transepithelial and accelerated epithelium-off pulsed-light accelerated corneal collagen cross-linking (CXL). METHODS: A total of 24 New Zealand rabbits were analyzed after sham operation (control) or transepithelial or epithelium-off operation (45 mW/cm for both). The transepithelial group was treated with pulsed-light ultraviolet A for 5 minutes 20 seconds, and the epithelium-off group was treated for 90 seconds...
July 2017: Cornea
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