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https://www.readbyqxmd.com/read/27898351/a-case-report-of-small-bowel-obstruction-secondary-to-congenital-peritoneal-band-in-adult
#1
Yahmadi Abdelwahed, Rebii Saber, Ben Ismail Imen, Zenaidi Hakim, Zoghlami Ayoub
INTRODUCTION: Small bowel obstruction (SBO) is common in adult surgical procedures, mainly due to postoperative adhesions. Acute SBO in adults without history of abdominal surgery, trauma or clinical hernia is less common and has various etiologies. Congenital band is an extremely rare cause. PRESENTATION OF CASE: A 56-year-old man was admitted to our hospital with a two-day history of abdominal pain and bilious vomiting. He had no history of abdominal surgery or any other medical problems...
November 18, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27896150/early-reoperations-after-primary-repair-of-jejunoileal-atresia-in-newborns
#2
Fanny Yeung, Yuk Him Tam, Yuen Shan Wong, Siu Yan Tsui, Hei Yi Wong, Kristine Kit Yi Pang, Christopher H Houben, Jennifer Wai Cheung Mou, Kin Wai Chan, Kim Hung Lee
Aim: To review nine-year experience in managing jejuno-ileal atresia (JIA) by primary resection and anastomosis and identify factors associated with reoperations. Methods: From April 2006 to May 2015, all consecutive neonates who underwent bowel resection and primary anastomosis for JIA were analyzed retrospectively. Patients with temporary enterostomy were excluded. Patient demographics, types of atresia, surgical techniques, need for reoperations, and long-term outcomes were investigated. Results: A total of forty-three neonates were included, in which nineteen (44...
October 2016: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/27890350/the-histophysiology-and-pathophysiology-of-the-peritoneum
#3
REVIEW
J O A M van Baal, K K Van de Vijver, R Nieuwland, C J F van Noorden, W J van Driel, A Sturk, G G Kenter, L G Rikkert, C A R Lok
The peritoneum is an extensive serous organ with both epithelial and mesenchymal features and a variety of functions. Diseases such as inflammatory peritonitis and peritoneal carcinomatosis can induce disturbance of the complex physiological functions. To understand the peritoneal response in disease, normal embryonic development, anatomy in healthy conditions and physiology of the peritoneum have to be understood. This review aims to summarize and discuss the literature on these basic peritoneal characteristics...
November 13, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27871915/inhibition-of-siglec-1-by-lentivirus-mediated-small-interfering-rna-attenuates-atherogenesis-in-apoe-deficient-mice
#4
Yi-Song Xiong, Ai-Lin Wu, Dong Mu, Juan Yu, Ping Zeng, Yi Sun, Jie Xiong
BACKGROUND: Siglec-1 is highly expressed on circulating monocytes and plaque macrophages in atherosclerotic patients, but the exact role of Siglec-1 in atherosclerosis has not been elucidated. METHODS: Lentiviral vector containing small interfering RNA targeting Siglec-1 (Lv-shSiglec-1) or control vector (Lv-shNC) were injected intravenously into 6-week old Apoe(-/-) mice. Then onset of atherosclerosis was observed. RESULTS: Siglec-1 was highly expressed in aortic plaques and it can be down-regulated by Lv-shSiglec-1 injection...
November 15, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27869192/peritoneal-adhesion-prevention-with-a-biodegradable-and-injectable-n-o-carboxymethyl-chitosan-aldehyde-hyaluronic-acid-hydrogel-in-a-rat-repeated-injury-model
#5
Linjiang Song, Ling Li, Tao He, Ning Wang, Suleixin Yang, Xi Yang, Yan Zeng, Wenli Zhang, Li Yang, Qinjie Wu, Changyang Gong
Postoperative peritoneal adhesion is one of the serious issues because it induces severe clinical disorders. In this study, we prepared biodegradable and injectable hydrogel composed of N,O-carboxymethyl chitosan (NOCC) and aldehyde hyaluronic acid (AHA), and assessed its anti-adhesion effect in a rigorous and severe recurrent adhesion model which is closer to clinical conditions. The flexible hydrogel, which gelated in 66 seconds at 37 °C, was cross-linked by the schiff base derived from the amino groups of NOCC and aldehyde groups in AHA...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27864142/glycogen-storage-disease-type-ib-neutrophils-exhibit-impaired-cell-adhesion-and-migration
#6
Goo-Young Kim, Young Mok Lee, Joon Hyun Kwon, Hyun Sik Jun, Janice Chou
Glycogen storage disease type Ib (GSD-Ib), characterized by impaired glucose homeostasis, neutropenia, and neutrophil dysfunction, is an inherited autosomal recessive disorder caused by a deficiency in the glucose-6-phosphate transporter (G6PT). Neutrophils play an essential role in the defense against invading pathogens. The recruitment of neutrophils towards the inflammation sites in response to inflammatory stimuli is a tightly regulated process involving rolling, adhesion, and transmigration. In this study, we investigated the role of G6PT in neutrophil adhesion and migration using in vivo and in vitro models...
November 15, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27863439/re-purposing-of-curcumin-as-an-anti-metastatic-agent-for-the-treatment-of-epithelial-ovarian-cancer-in-vitro-model-using-cancer-stem-cell-enriched-ovarian-cancer-spheroids
#7
Misi He, Dong Wang, Dongling Zou, Chen Wang, Bruno Lopes-Bastos, Wen G Jiang, John Chester, Qi Zhou, Jun Cai
Malignant epithelial ovarian cancer (EOC) spheroids high frequently are detected in the malignant ascites of the patients with the extensive peritoneal metastasis of ovarian cancer, which represent a significant obstacle to efficacious treatment. Clinical data also suggested that EOC spheroids play a putative role in the development of chemoresistance. Since standard surgery and conventional chemotherapy is the only available treatment, there is an urgent need to identify a more effective therapeutic strategy...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27843732/resection-of-large-metachronous-liver-metastasis-with-gastric-origin-case-report-and-review-of-the-literature
#8
REVIEW
Ionut Negoi, Alexandru Runcanu, Sorin Paun, Ruxandra Irina Negoi, Mircea Beuran
INTRODUCTION: Increasing evidence suggests that surgical resection may be offered to a subgroup of patients with liver metastasis of gastric adenocarcinoma. The aim of this case report is to illustrate the surgical resection of a single liver metachronous recurrence twelve months after a radical total gastrectomy for cancer. CASE REPORT: A 63-year-old male patient with an Eastern Cooperative Oncology Group performance status of 1 was referred to our hospital for a single, large liver metastasis, twelve months after a radical total gastrectomy and DII lymphadenectomy for upper third gastric adenocarcinoma...
October 3, 2016: Curēus
https://www.readbyqxmd.com/read/27842504/epcam-as-multi-tumour-target-for-near-infrared-fluorescence-guided-surgery
#9
P B A A van Driel, M C Boonstra, H A J M Prevoo, M van de Giessen, T J A Snoeks, Q R J G Tummers, S Keereweer, R A Cordfunke, A Fish, J D H van Eendenburg, B P F Lelieveldt, J Dijkstra, C J H van de Velde, P J K Kuppen, A L Vahrmeijer, C W G M Löwik, C F M Sier
BACKGROUND: Evaluation of resection margins during cancer surgery can be challenging, often resulting in incomplete tumour removal. Fluorescence-guided surgery (FGS) aims to aid the surgeon to visualize tumours and resection margins during surgery. FGS relies on a clinically applicable imaging system in combination with a specific tumour-targeting contrast agent. In this study EpCAM (epithelial cell adhesion molecule) is evaluated as target for FGS in combination with the novel Artemis imaging system...
November 14, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27834358/intraperitoneal-immunotherapy-historical-perspectives-and-modern-therapy
#10
REVIEW
W F Morano, A Aggarwal, P Love, S D Richard, J Esquivel, W B Bowne
Intraperitoneal immunotherapy represents a novel strategy for the management of peritoneal metastases (PM). Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has remained the gold standard of treatment for patients with PM, yet despite optimal treatment, recurrence rates remain high and long-term survival poor. From Coley's toxins to immune checkpoint inhibitors, the wide variety of anticancer immunotherapeutic strategies are now garnering attention for control of regional disease of the peritoneal cavity...
November 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27833044/statins-prevent-cognitive-impairment-after-sepsis-by-reverting-neuroinflammation-and-microcirculatory-endothelial-dysfunction
#11
Patricia A Reis, Pedro C B Alexandre, Joana C D'Avila, Luciana D Siqueira, Barbara Antunes, Vanessa Estato, Eduardo V Tibiriça, Franck Verdonk, Tarek Sharshar, Fabrice Chrétien, Hugo C Castro-Faria-Neto, Fernando A Bozza
Acute brain dysfunction is a frequent condition in sepsis patients and is associated with increased mortality and long-term neurocognitive consequences. Impaired memory and executive function are common findings in sepsis survivors. Although neuroinflammation and blood-brain barrier dysfunction have been associated with acute brain dysfunction and its consequences, no specific treatments are available that prevent cognitive impairment after sepsis. Experimental sepsis was induced in Swiss Webster mice by intraperitoneal injection of cecal material (5 mg/kg, 500 μL)...
November 7, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27831589/the-anti-inflammatory-vasostatin-2-attenuates-atherosclerosis-in-apoe-mice-and-inhibits-monocyte-macrophage-recruitment
#12
Weixin Xiong, Xiaoqun Wang, Daopeng Dai, Bao Zhang, Lin Lu, Rong Tao
We showed previously that reduced level of vasostatin-2 (VS-2) correlates to the presence and severity of coronary artery disease. In this study, we aimed to figure out the role of chromogranin A (CGA) derived VS-2 in the development of atherosclerosis and monocyte/macrophage recruitment. Apolipoprotein E-deficient (ApoE(-/-)) mice fed a high-fat diet exhibited attenuated lesion size by 65 % and 41 % in En face and aortic root Oil red O staining, MOMA-2 positive area by 64 %, respectively, in VS-2 treatment group compared with PBS group...
November 10, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27823622/main-pathways-of-action-of-brazilian-red-propolis-on-the-modulation-of-neutrophils-migration-in-the-inflammatory-process
#13
Bruno Bueno-Silva, Marcelo Franchin, Claudiney de Freitas Alves, Carina Denny, David Fernando Colón, Thiago Mattar Cunha, Severino Matias Alencar, Marcelo Henrique Napimoga, Pedro Luiz Rosalen
BACKGROUND: Brazilian propolis is popularly used as treatment for different diseases including the ones with inflammatory origin. Brazilian red propolis chemical profile and its anti-inflammatory properties were recently described however, its mechanism of action has not been investigated yet. AIM: Elucidate Brazilian red propolis major pathways of action on the modulation of neutrophil migration during the inflammatory process. METHODS: The ethanolic extract of propolis (EEP) activity was investigated for neutrophil migration into the peritoneal cavity, intravital microscopy (rolling and adhesion of leukocytes), quantification of cytokines TNF-α, IL-1β and chemokines CXCL1/KC, CXCL2/MIP-2, neutrophil chemotaxis induced by CXCL2/MIP-2, calcium influx and CXCR2 expression on neutrophils...
December 1, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27819273/neovestitol-an-isoflavonoid-isolated-from-brazilian-red-propolis-reduces-acute-and-chronic-inflammation-involvement-of-nitric-oxide-and-il-6
#14
Marcelo Franchin, David F Colón, Marcos G da Cunha, Fernanda V S Castanheira, André L L Saraiva, Bruno Bueno-Silva, Severino M Alencar, Thiago M Cunha, Pedro L Rosalen
Isoflavonoids have been largely studied due to their distinct biological activities identified thus far. Herein, we evaluated the activity of neovestitol, an isoflavonoid isolated from Brazilian red propolis, in acute and chronic inflammation. As for acute inflammation, we found that neovestitol reduced neutrophil migration, leukocyte rolling and adhesion, as well as expression of ICAM-1 in the mesenteric microcirculation during lipopolysaccharide-induced acute peritonitis. No changes were observed in the levels of TNF-α, CXCL1/KC and CXCL2/MIP-2 upon pretreatment with neovestitol...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27816772/biochemical-and-functional-characterization-of-glycosaminoglycans-released-from-degranulating-rat-peritoneal-mast-cells-insights-into-the-physiological-role-of-endogenous-heparin
#15
Rebecca Lever, Amir Smailbegovic, Yanira Riffo-Vasquez, Elaine Gray, John Hogwood, Stephen M Francis, Neville V Richardson, Clive P Page, Barbara Mulloy
The properties of commercially prepared heparin as an anticoagulant and antithrombotic agent in medicine are better understood than is the physiological role of heparin in its native form, where it is uniquely found in the secretory granules of mast cells. In the present study we have isolated and characterised the glycosaminoglycans (GAGs) released from degranulating rat peritoneal mast cells. Analysis of the GAGs by NMR spectroscopy showed the presence of both heparin and the galactosaminoglycan dermatan sulphate; heparinase digestion profiles and measurements of anticoagulant activity were consistent with this finding...
November 2, 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27807193/ptpn22-is-a-critical-regulator-of-fc%C3%AE-receptor-mediated-neutrophil-activation
#16
Sonja Vermeren, Katherine Miles, Julia Y Chu, Donald Salter, Rose Zamoyska, Mohini Gray
Neutrophils act as a first line of defense against bacterial and fungal infections, but they are also important effectors of acute and chronic inflammation. Genome-wide association studies have established that the gene encoding the protein tyrosine phosphatase nonreceptor 22 (PTPN22) makes an important contribution to susceptibility to autoimmune disease, notably rheumatoid arthritis. Although PTPN22 is most highly expressed in neutrophils, its function in these cells remains poorly characterized. We show in this article that neutrophil effector functions, including adhesion, production of reactive oxygen species, and degranulation induced by immobilized immune complexes, were reduced in Ptpn22(-/-) neutrophils...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27807019/abdominal-tuberculosis-an-old-disease-surprising-young-doctors
#17
Marta David Sousa, Joana Batista, Patricia Pacheco, Vitor Nunes
Tuberculosis remains a worldwide public health concern. Atypical extrapulmonary presentations may delay the diagnosis and treatment. We present the case of an adult woman admitted to the emergency department with bowel obstruction. The putative intraoperative diagnostic hypothesis was ovarian cancer with peritoneal dissemination. Histopathological analysis showed a chronic granulomatous inflammatory disease with acid-fast bacilli. The patient was started on an alternative parenteral antituberculosis drug combination until oral feeding was available...
November 2, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27799334/distinct-roles-of-integrins-%C3%AE-x%C3%AE-2-and-%C3%AE-m%C3%AE-2-on-leukocyte-subpopulations-during-inflammation-and-antimicrobial-responses
#18
Samir Jawhara, Elzbieta Pluskota, Wei Cao, Edward F Plow, Dmitry A Soloviev
Integrins αMβ2 and αXβ2 are homologous adhesive receptors that are expressed on many of the same leukocyte populations and bind many of the same ligands. Although αMβ2 was extensively characterized and implicated in leukocyte inflammatory and immune functions, the roles of αXβ2 remain largely obscure. Here, we tested the ability of mice deficient in integrins αMβ2 or αXβ2 to deal with opportunistic infections and the capacity of cells derived from these animals to execute inflammatory functions...
October 31, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27790874/preoperative-colonic-cancer-tattooing-using-the-near-infrared-fluorescence-laparoscopic-imaging-system
#19
Yoshiaki Ozawa, Masahiko Murakami, Makoto Watanabe, Sota Yoshizawa, Satoru Goto, Koji Otsuka, Takeshi Aoki
INTRODUCTION: To identify a colorectal cancer tumor site for surgery, preoperative endoscopic marking methods, such as India ink tattooing or clipping, are generally performed. However, India ink tattooing causes problems such as impaired surgical view because of adverse events, ink leakage into the peritoneal cavity, and peritonitis or adhesion ileus as a result of leakage. The clipping method requires checking by palpation, which is unsuitable for laparoscopic surgery. MATERIALS AND SURGICAL TECHNIQUES: We devised a preoperative marking method for colorectal cancer surgery (laparotomy) by applying the fluorescent dye indocyanine green...
November 2016: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/27790873/preperitoneal-onlay-mesh-repair-for-ventral-abdominal-wall-and-incisional-hernia-a-novel-technique
#20
Pc George Yang, Lm Karen Tung
INTRODUCTION: Intraperitoneal onlay mesh repair is a current technique for laparoscopic repair of ventral and incisional hernias. However, the placement of synthetic mesh intraperitoneally may potentially lead to mesh-induced complications such as adhesive intestinal obstruction, enterocutaneous fistula, or even mesh erosion into organs. Inspired by the concept of laparoscopic inguinal hernia repair, we developed a novel technique: preperitoneal onlay mesh repair (PPOM). This involves placing the mesh in the preperitoneal plane to help eliminate mesh-induced complications...
November 2016: Asian Journal of Endoscopic Surgery
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