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https://www.readbyqxmd.com/read/29151228/previously-implanted-intra-peritoneal-mesh-increases-morbidity-during-re-laparoscopy-a-retrospective-case-matched-cohort-study
#1
A Sharma, P Chowbey, N S Kantharia, M Baijal, V Soni, R Khullar
PURPOSE: Laparoscopic ventral hernia repair (LVHR) with intra-peritoneal mesh placement is standard surgical treatment of abdominal wall hernias. During laparoscopic re-intervention, we examined adhesions that develop after previous intra-peritoneal mesh placement and ascertained morbidity and risk of adverse events. METHODS: This is a retrospective, case-matched comparison of three patient groups-previous intra-peritoneal mesh (Group A), previous abdominal surgery (Group B) and no previous abdominal surgery (Group C)...
November 18, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29148537/adenomatoid-tumors-of-the-male-and-female-genital-tract-are-defined-by-traf7-mutations-that-drive-aberrant-nf-kb-pathway-activation
#2
Benjamin Goode, Nancy M Joseph, Meredith Stevers, Jessica Van Ziffle, Courtney Onodera, Eric Talevich, James P Grenert, Iwei Yeh, Boris C Bastian, Joanna J Phillips, Karuna Garg, Joseph T Rabban, Charles Zaloudek, David A Solomon
Adenomatoid tumors are the most common neoplasm of the epididymis, and histologically similar adenomatoid tumors also commonly arise in the uterus and fallopian tube. To investigate the molecular pathogenesis of these tumors, we performed genomic profiling on a cohort of 31 adenomatoid tumors of the male and female genital tracts. We identified that all tumors harbored somatic missense mutations in the TRAF7 gene, which encodes an E3 ubiquitin ligase belonging to the family of tumor necrosis factor receptor-associated factors (TRAFs)...
November 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29139022/effect-of-plasma-activated-lactated-ringer-s-solution-on-pancreatic-cancer-cells-in-vitro-and-in-vivo
#3
Yusuke Sato, Suguru Yamada, Shigeomi Takeda, Norifumi Hattori, Kae Nakamura, Hiromasa Tanaka, Masaaki Mizuno, Masaru Hori, Yasuhiro Kodera
BACKGROUND: The medical applications of nonequilibrium atmospheric pressure plasma in cancer therapy have attracted attention. We previously reported on the antitumor effect of plasma-activated medium. However, this approach requires plasma-activated liquids that are administrable to the human body. In this study, we produced plasma-activated lactated Ringer's solution (PAL) and evaluated its antitumor effect and mechanism. Furthermore, we evaluated the effect of the intraperitoneal administration of PAL using a peritoneal dissemination mouse tumor model...
November 14, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29127274/effect-of-hydrogen-rich-saline-on-postoperative-intra-abdominal-adhesion-bands-formation-in-mice
#4
Zhong Liu, Sanfang Cheng, Changwei Gu, Honghong Pei, Xin Hong
BACKGROUND Postsurgical peritoneal adhesions (PPAs) are pathologic fibrous bands within the peritoneal cavity. The aim of this study was to investigate the protective effect of hydrogen-rich saline (HRS) on PPAs formation in mice. MATERIAL AND METHODS Adhesions were induced in mice using the cecum rubbing model. The mice were allocated into 4 groups: control sham group without cecum rubbing; PPA group with saline applied intraperitoneally (i.p.) daily after cecum rubbing; PPA+HRS (5) group with 5 ml/kg of HRS applied i...
November 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29123001/effective-remedy-for-encapsulating-peritoneal-sclerosis-with-ureteroileal-fistula
#5
Masataka Banshodani, Hideki Kawanishi, Sadanori Shintaku, Masahiro Yamashita, Misaki Moriishi, Shinichiro Tsuchiya
Encapsulating peritoneal sclerosis (EPS), treated with surgical enterolysis as a final option, may become refractory to surgical intervention due to intraperitoneal complications. We report the case of a 59-year-old man presenting with EPS who underwent enterolysis at the age of 50, following 15 years of peritoneal dialysis (PD) and peritonitis. During the patient's first surgery, complete surgical enterolysis could not be performed due to severe intestinal adhesions with a deteriorated/calcified small bowel...
November 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29102485/adhesive-internal-hernia-multidetector-ct-findings-and-clinical-relevance
#6
C-Y Lu, M Xu, J Lin, Y Chen, Y Gao, Z-F Wang, Z-W Zhao, J-J Song, H-F Que, J-J Ji
AIM: To review the clinical and multidetector computed tomography (MDCT) features of adhesive internal hernias (IHs) and to ascertain specific MDCT criteria to assist in the diagnosis of adhesive IHs and the early detection of intestinal strangulation. MATERIALS AND METHODS: Medical records and preoperative abdominal MDCT findings of 34 patients with surgically confirmed abdominal adhesive IHs were analysed retrospectively. RESULTS: The specific MDCT features of adhesive IHs included the following: dislocating and clustering of intestinal segments (100%); stretching and crowding of the mesenteric vessels (100%); presence of hernial orifice (88...
November 1, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29089624/combating-virulence-of-gram-negative-bacilli-by-ompa-inhibition
#7
Xavier Vila-Farrés, Raquel Parra-Millán, Viviana Sánchez-Encinales, Monica Varese, Rafael Ayerbe-Algaba, Nuria Bayó, Salvador Guardiola, María Eugenia Pachón-Ibáñez, Martin Kotev, Jesús García, Meritxell Teixidó, Jordi Vila, Jerónimo Pachón, Ernest Giralt, Younes Smani
Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29083537/impact-of-unplanned-events-on-early-postoperative-results-of-minimally-invasive-esophagectomy
#8
Xufeng Guo, Bo Ye, Yu Yang, Yifeng Sun, Rong Hua, Xiaobing Zhang, Teng Mao, Zhigang Li
BACKGROUND: Minimally invasive esophagectomy (MIE) is increasingly performed worldwide. Unplanned events during thoracoscopy or laparoscopy can jeopardize the procedure, sometimes necessitating conversion to open surgery. The aim of this study was to evaluate the impact of unplanned events on early postoperative outcomes after MIE. METHOD: A consecutive group of 303 patients who underwent MIE between January 2011 and December 2015 were reviewed. The patients were allocated to two groups comprising those with (G-UPE, 85 patients) and without unplanned events (G-Regular, 218 patients)...
October 30, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29059609/a-case-of-laparoscopy-assisted-vaginal-cuff-suturing-for-vaginal-cuff-dehiscence-after-total-laparoscopic-hysterectomy
#9
Tomoatsu Jimi, Rumiko Yamamoto, Koji Seo, Mari Matsuoka, Saori Hata, Yukiko Ando, Hiromi Miyata, Yuki Kozono, Natsuki Tsuji, Akiko Okuda, Kentaro Sekiyama, Koichi Terakawa, Tadayoshi Nagano
INTRODUCTION: Vaginal cuff dehiscence after hysterectomy is a rare complication and occurs in less than 1% of patients. It can present with serious complications, such as bowel evisceration and peritonitis. PRESENTATION OF CASE: A 51-year-old multigravida Korean woman underwent total laparoscopic hysterectomy for leiomyoma. Six months later, she reported lower abdominal pain and vaginal bleeding. Physical examination revealed rebound tenderness in the lower abdomen, and pelvic examination showed a small amount of vaginal bleeding with an evisceration of the small intestine through the vagina that exhibited healthy peristalsis...
October 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29059097/preoperative-risk-stratification-of-endometrial-carcinoma-l1cam-as-a-biomarker
#10
Annukka Pasanen, Mikko Loukovaara, Taru Tuomi, Ralf Bützow
OBJECTIVE: Preoperative or intraoperative risk assessment models are used to stratify patients with endometrial carcinoma to lymphadenectomy. Our aim was to determine whether preoperative analysis of L1 cell adhesion molecule (L1CAM) can improve risk assessment. METHODS: Immunohistochemical L1CAM staining was performed on endometrial biopsies of 241 patients and paired hysterectomy samples of 75 patients. Risk assessment models based on preoperative histologic type and grade, myometrial invasion, and/or tumor diameter and alternative models incorporating preoperative L1CAM were compared with regard to their capability of predicting lymph nodal or distant metastasis...
September 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29046801/outcome-of-decompression-using-a-transnasal-ileus-tube-in-malignant-adhesive-bowel-obstruction-a-retrospective-study
#11
Xiang-Jun Han, Fan Zhao, Hong-Ying Su, Ke Xu
Malignant adhesive bowel obstruction caused by peritoneal carcinomatosis is a common complication of advanced abdominal malignancies, and surgical treatment provides little benefit. The present study was undertaken to evaluate the decompression efficacy of a transnasal ileus tube under X-ray guidance, with benign adhesive bowel obstruction patients serving as the control group. A total of 21 patients with malignant adhesive bowel obstruction and 60 patients with benign conditions were enrolled between February 2011 and March 2015...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29042927/novel-type-of-peritoneocentesis-trocar-assisted-distal-ventriculoperitoneal-shunt-placement-with-supervision-via-a-one-port-laparoscope
#12
Guangming Wang, Jinlu Yu, Yongxin Luan, Yanwu Han, Shuanglin Fu
Ventriculoperitoneal shunts (VPS) are the primary treatment for hydrocephalus and are associated with a high risk of complications, specifically in patients who are obese or have abdominal adhesions or shunt revisions. The present study describes the use of a novel type of peritoneal catheter peritoneocentesis trocar insertion with the assistance of a one-port laparoscope. A total of 36 patients with hydrocephalus underwent this novel type of peritoneocentesis trocar-assisted VPS. The distal shunt catheter was placed into the right subdiaphragmatic space and the catheter was traversed through a single hole drilled through the liver falciform ligament...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29039777/the-specific-mitogen-and-stress-activated-protein-kinase-msk1-inhibitor-sb-747651a-modulates-chemokine-induced-neutrophil-recruitment
#13
Mokarram Hossain, Entesar Omran, Najia Xu, Lixin Liu
Mitogen-activated protein kinase (MAPK) signaling is involved in a variety of cellular functions. MAPK-dependent functions rely on phosphorylation of target proteins such as mitogen- and stress-activated protein kinase 1 (MSK1). MSK1 participates in the early gene expression and in the production of pro- and anti-inflammatory cytokines. However, the role of MSK1 in neutrophil recruitment remains elusive. Here, we show that chemokine macrophage inflammatory protein-2 (CXCL2) enhances neutrophil MSK1 expression...
October 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29037504/an-investigation-of-virulence-factors-of-legionella-pneumophila-environmental-isolates
#14
Elif Özlem Arslan-Aydoğdu, Ayten Kimiran
Nine Legionella pneumophila strains isolated from cooling towers and a standard strain (L. pneumophila serogroup 1, ATCC 33152, Philadelphia 1) were analyzed and compared in terms of motility, flagella structure, ability to form biofilms, enzymatic activities (hemolysin, nucleases, protease, phospholipase A, phospholipase C, acid phosphatase, alkaline phosphatase and lipase), hemagglutination capabilities, and pathogenicity in various host cells (Acanthamoeba castellanii ATCC 30234, mouse peritoneal macrophages and human peripheral monocytes)...
July 22, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29030625/pharmacological-hif-inhibition-attenuates-postoperative-adhesion-formation
#15
Moritz J Strowitzki, Alina S Ritter, Praveen Radhakrishnan, Jonathan M Harnoss, Vanessa M Opitz, Marvin Biller, Julian Wehrmann, Ulrich Keppler, Jana Scheer, Markus Wallwiener, Thomas Schmidt, Alexis Ulrich, Martin Schneider
Peritoneal adhesions represent a common complication of abdominal surgery, and tissue hypoxia is a main determinant in adhesion formation. Reliable therapeutic options to reduce peritoneal adhesions are scarce. We investigated whether the formation of postsurgical adhesions can be affected by pharmacological interference with hypoxia-inducible factors (HIFs). Mice were treated with a small molecule HIF-inhibitor, YC-1 (3-[5'-Hydroxymethyl-2'-furyl]-1-benzyl-indazole), or vehicle three days before and seven days after induction of peritoneal adhesions or, alternatively, once during induction of peritoneal adhesions...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030291/evaluation-of-a-spray-type-novel-dextrin-hydrogel-adhesion-barrier-under-laparoscopic-conditions-in-a-porcine-uterine-horn-adhesion-model
#16
Miho Kai, Kazuha Maeda, Masako Tasaki, Shinichirou Kira, Shintarou Nakamura, Naotaka Chino, Hitomi Hagiwara, Hitoshi Nishida, Tetsuro Kawanishi
STUDY OBJECTIVE: To establish a porcine uterine horn adhesion model that mimicked laparoscopic procedures and use it to investigate the effect of a spray-type, novel dextrin hydrogel adhesion barrier (AdSpray) on postsurgical adhesions. DESIGN: Single: Single-blind randomized controlled trial (Canadian Task Force Classification I). SETTING: Certified animal research facility. SUBJECTS: 16 female pigs. INTERVENTIONS: All animals underwent laparoscopically-assisted adhesion-inducing surgery...
October 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29024447/the-influences-of-a-novel-anti-adhesion-device-thermally-cross-linked-gelatin-film-on-peritoneal-dissemination-of-tumor-cells-the-in-vitro-and-in-vivo-experiments-using-murine-carcinomatous-peritonitis-models
#17
Hiroe Miyamoto, Hiroyuki Tsujimoto, Tsunehito Horii, Yuki Ozamoto, Joe Ueda, Toshitaka Takagi, Naoto Saitoh, Akeo Hagiwara
To create anti-adhesive materials to be more effective and safer, we developed a thermally cross-linked gelatin film that showed superior anti-adhesive effects with excellent peritoneal regeneration. However, it may act as a convenient scaffold for tumor cell growth, thereby accelerating peritoneal dissemination when used in surgery for abdominal tumors. In this study, we tried to clarify this issue using mouse carcinomatous peritonitis models. First, we examined the in vitro tumor cell growth of mouse B16 melanoma or Colon26 cells on the gelatin film or the conventional hyarulonate/carboxymethylcellulose film...
October 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29020699/the-first-homemade-colonoscopy-trainer
#18
Dominik Andrzej Walczak, Maciej Grajek, Paulina Agnieszka Walczak, Magdalena Tuliszka-Gołowkin, Roman Massopust, Dariusz Pawełczak, Zbigniew Pasieka, Łukasz Krakowczyk, Adam Maciejewski
Introduction Colonoscopy trainers have gained recognition for improving endoscopy skills and preparing for real procedures on humans. Unfortunately, due to their high price, commercial simulators are hard to obtain, especially for small medical centers. However, a solution might be to construct a device for themselves. Aim Our goal was to build a relatively cheap and easy-to-construct simulator for residents who want to start learning colonoscopy. Materials and methods The box model colonoscopy trainer was designed and constructed...
October 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28988370/morphologic-characteristics-of-macroscopic-peritoneal-finding-in-patients-with-peritoneal-dialysis
#19
Chieko Hamada, Hirotaka Nakamoto, Yusuke Suzuki
Peritoneal dialysis (PD) has been an attractive treatment for end-stage kidney disease. Long-term exposure to the PD solution creates functional and morphological alterations, and these alterations diminish the efficacy of PD. It is important to establish an evaluation of the changes in PD patients and strategies for the prevention of PD damage and encapsulating peritoneal sclerosis (EPS). We determined the relationship between clinical findings and macroscopic morphological findings by laparoscopy in patients receiving PD...
October 7, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28980533/rosuvastatin-administered-intraperitoneally-reduces-the-formation-of-postoperative-adhesions-in-rats
#20
Stefan Chiorescu, Nicolae Ovidiu Grad, Ion Aurel Mironiuc, Octavian Aurel Andercou
OBJECTIVES: The purpose of the present experimental research was to assess the efficacy of intraperitoneal administration of rosuvastatin in preventing the formation of postoperative peritoneal adhesions. MATERIAL AND METHOD: Peritoneal adhesions were induced in 120 male rats of the Wistar-Bratislava breed, divided into 4 groups (n=30), using a parietal and visceral abrasion model. Group I was designated as the control group; in the case of group II, a saline solution was administered intraperitoneally, while in the case of groups III and IV, rosuvastatin solution with a concentration of 10 mg/kg and 5 mg/kg, respectively, was administered in a single dose, during laparotomy...
September 26, 2017: Annali Italiani di Chirurgia
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