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https://www.readbyqxmd.com/read/29777326/sirolimus-coated-poly-l-lactic-acid-modified-polypropylene-mesh-with-minimal-intra-peritoneal-adhesion-formation-in-a-rat-model
#1
S Lu, W Hu, Z Zhang, Z Ji, T Zhang
PURPOSE: This study evaluated the manufacturing method and anti-adhesion properties of a new composite mesh in the rat model, which was made from sirolimus (SRL) grafts on a poly(L-lactic acid) (PLLA)-modified polypropylene (PP) hernia mesh. METHODS: PLLA was first grafted onto argon-plasma-treated native PP mesh through catalysis of stannous chloride. SRL was grafted onto the surface of PP-PLLA meshes using catalysis of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and 4-dimethylaminopyridine (DMAP) in a CH2 Cl2 solvent...
May 18, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29774141/exosome-mediated-peritoneal-dissemination-in-gastric-cancer-and-its-clinical-applications
#2
REVIEW
Kai-Bo Chen, Jian Chen, Xiao-Li Jin, Yi Huang, Qiu-Ming Su, Li Chen
The prognosis of patients with peritoneal dissemination from gastric cancer is poor, and the underlying molecular mechanism remains unclear. Exosomes, as macromolecular phospholipid bilayer vesicles comprising of proteins, nucleic acids and lipids, serve as mediators of cell-cell communication. Gastric cancer tumor-derived exosomes may be involved in the pathological process of peritoneal dissemination by mediating crosstalk between cancer cells and mesothelial cells, to result in the induction of enhanced tumor growth, migratory, adhesive and invasive abilities, peritoneal fibrosis and apoptosis, mesothelial-to-mesenchymal transition, angiogenesis and chemoresistance...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29767333/laparoscopic-adhesiolysis-not-for-all-patients-not-for-all-surgeons-not-in-all-centres
#3
Salomone Di Saverio, Arianna Birindelli, Richard Ten Broek, Justin R Davies, Matteo Mandrioli, Ville Sallinen
ASBO is a common cause of emergency surgery and the use of laparoscopy for the treatment of these patients is still under debate and conflicting results have been published, in particular regarding the high risk of iatrogenic bowel injury. In fact, although over the last few years there has been an increasing enthusiasm in the surgical community about the advantages and potential better outcomes of laparoscopic management of adhesive small bowel obstruction (ASBO), recently published studies have introduced a significant word of caution...
May 16, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29762033/isolation-synthesis-and-antisepsis-effects-of-a-c-methylcoumarinochromone-isolated-from-abronia-nana-cell-culture
#4
Wonhwa Lee, Doohyun Lee, Yuri Lee, Taeho Lee, Kyung-Sik Song, Eun-Ju Yang, Jong-Sup Bae
Only a few isoflavones have been isolated from plants of the genus Abronia. The biological properties of compounds isolated from Abronia species have not been well established, and their antisepsis effects have not been reported yet. In the present study, a new C-methylcoumarinochromone, was isolated from Abronia nana suspension cultures. Its structure was deduced as 9,11-dihydroxy-10-methylcoumarinochromone (boeravinone Y, 1) by spectroscopic data analysis and verified by chemical synthesis. The potential inhibitory effects of 1 against high mobility group box 1 (HMGB1)-mediated septic responses were investigated...
May 15, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29761278/laparoscopic-totally-extraperitoneal-tep-inguinal-hernia-repair-in-patients-with-previous-lower-abdominal-surgery
#5
Toru Zuiki, Jun Ohki, Masanori Ochi, Alan Kawarai Lefor
BACKGROUND: We have performed laparoscopic totally extraperitoneal (TEP) repair for inguinal hernia repair for the last 20 years. We use two balloon dilators (sphere and kidney type) to dissect the preperitoneal space for the TEP repair. It may be difficult to obtain exposure in patients who previously underwent lower abdominal surgery, because of adhesions to the abdominal wall. We reviewed our experience with inguinal hernia repairs to retrospectively analyze factors that limit the laparoscopic TEP approach...
May 14, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29747214/intestinal-perforation-due-to-deep-infiltrating-endometriosis-during-pregnancy-case-report
#6
Márcia Mendonça Carneiro, Luciana Maria Pyramo Costa, Maria Das Graças Torres, Patrícia Salomé Gouvea, Ivete de Ávila
We report the case of a 33 year-old woman who complained of severe dysmenorrhea since menarche. From 2003 to 2009, she underwent 4 laparoscopies for the treatment of pain associated with endometriosis. After all four interventions, the pain recurred despite the use of gonadotropin-releasing hormone (GnRH) analogues and the insertion of a levonorgestrel intrauterine system (LNG-IUS). Finally, a colonoscopy performed in 2010 revealed rectosigmoid stenosis probably due to extrinsic compression. The patient was advised to get pregnant before treating the intestinal lesion...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29743986/the-role-of-oxidative-stress-and-membrane-transport-systems-during-endometriosis-a-fresh-look-at-a-busy-corner
#7
REVIEW
Salvatore Giovanni Vitale, Stella Capriglione, Isabel Peterlunger, Valentina Lucia La Rosa, Amerigo Vitagliano, Marco Noventa, Gaetano Valenti, Fabrizio Sapia, Roberto Angioli, Salvatore Lopez, Giuseppe Sarpietro, Diego Rossetti, Gabriella Zito
Endometriosis is a condition characterized by the presence of endometrial tissue outside the uterine cavity, leading to a chronic inflammatory reaction. It is one of the most widespread gynecological diseases with a 10-15% prevalence in the general female population, rising up to 30-45% in patients with infertility. Although it was first described in 1860, its etiology and pathogenesis are still unclear. It is now accepted that inflammation plays a central role in the development and progression of endometriosis...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29739756/alternatively-activated-macrophages-upregulate-mesothelial-expression-of-p-selectin-to-enhance-adhesion-of-ovarian-cancer-cells
#8
Molly J Carroll, Kaitlin C Fogg, Harin A Patel, Harris B Krause, Anne-Sophie Mancha, Manish S Patankar, Paul S Weisman, Lisa Barroilhet, Pamela K Kreeger
Peritoneal metastasis of high-grade serous ovarian cancer (HGSOC) occurs when tumor cells suspended in ascites adhere to mesothelial cells. Despite the strong relationship between metastatic burden and prognosis in HGSOC, there are currently no therapies specifically targeting the metastatic process. We utilized a co-culture model and multivariate analysis to examine how interactions between tumor cells, mesothelial cells, and alternatively-activated macrophages (AAMs) influence the adhesion of tumor cells to mesothelial cells...
May 8, 2018: Cancer Research
https://www.readbyqxmd.com/read/29734717/thermosensitive-injectable-hydrogel-for-simultaneous-intraperitoneal-delivery-of-doxorubicin-and-prevention-of-peritoneal-adhesion
#9
Chih-Hao Chen, Chang-Yi Kuo, Shih-Hsien Chen, Shih-Hsuan Mao, Chih-Yen Chang, K T Shalumon, Jyh-Ping Chen
To improve intraperitoneal chemotherapy and to prevent postsurgical peritoneal adhesion, we aimed to develop a drug delivery strategy for controlled release of a chemotherapeutic drug from the intraperitoneally injected thermosensitive poly( N -isopropylacrylamide)-based hydrogel (HACPN), which is also endowed with peritoneal anti-adhesion properties. Anticancer drug doxorubicin (DOX) was loaded into the hydrogel (HACPN-DOX) to investigate the chemotherapeutic and adhesion barrier effects in vivo. A burst release followed by sustained release of DOX from HACPN-DOX was found due to gradual degradation of the hydrogel...
May 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29724896/oxidative-modifications-of-extracellular-matrix-promote-the-second-wave-of-inflammation-via-%C3%AE-2-integrins
#10
Valentin P Yakubenko, Kui Cui, Christopher L Ardell, Kathleen E Brown, Xiaoxia Z West, Detao Gao, Samantha Stefl, Robert G Salomon, Eugene A Podrez, Tatiana V Byzova
Early stages of inflammation are characterized by extensive oxidative insult by recruited and activated neutrophils. Secretion of peroxidases, including the main enzyme, myeloperoxidase, leads to the generation of reactive oxygen species. We show that this oxidative insult leads to polyunsaturated fatty acid, e.g. DHA, oxidation, and accumulation of its product 2-(ω-carboxyethyl)pyrrole (CEP), which, in turn, is capable of protein modifications. In vivo CEP is generated predominantly at the inflammatory sites in macrophage-rich areas...
May 3, 2018: Blood
https://www.readbyqxmd.com/read/29713558/effect-of-4dryfield-%C3%A2-ph-a-novel-adhesion-barrier-on-recurrence-of-intestinal-adhesions-after-extensive-visceral-adhesiolysis
#11
Gerhard Blumhardt, Matthias Haas, Stefanie Polte
Background: Adhesions occur after up to 97% of abdominal interventions causing chronic pain, infertility, and intestinal obstruction. Various concepts to prevent adhesions have been presented but mostly either have low efficacy or are not applicable in resective intestinal surgery or incomplete hemostasis. In this retrospective one-center clinical trial, the course of patients with extensive abdominal adhesiolysis and application of a recent starch-based formulation, 4DryField PH (4DF), is analyzed...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29695575/laparoscopic-left-hepatectomy-for-ruptured-hepatocellular-carcinoma-controlled-after-transcatheter-arterial-embolization-case-report-and-review-of-the-literature
#12
Shohei Yoshiya, Kentaro Iwaki, Akihiro Sakai, Shunsuke Fujita, Takahide Kawasaki, Fumitaka Yoshizumi, Shoji Hiroshige, Masahiro Okamoto, Kengo Fukuzawa, Akira Motohiro, Yoshihiko Maehara
BACKGROUND: Although spontaneous tumour rupture is a life-threatening complication of hepatocellular carcinoma (HCC), staged hepatectomy for HCC controlled after transcatheter arterial embolization (TAE) could provide a better prognosis. Laparoscopic liver resection (LLR) has been accepted worldwide and has been expanded from minor resection to anatomical major resection. We herein report the first case of pure laparoscopic left hepatectomy for ruptured HCC controlled after TAE. CASE REPORT: A 66-year-old man was transferred to our Institute because of abdominal pain and decreased consciousness...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29686882/pyosalpinges-after-hysterosalpingography-in-a-patient-with-lower-genital-tract-infection-and-managed-by-laparoscopic-surgery-in-a-resource-low-tertiary-hospital-case-report-and-literature-review
#13
Thomas Obinchemti Egbe, Fidelia Mbi Kobenge, Metogo Mbengono Junette Arlette, Eugene Belley-Priso
Background: Pyosalpinges (a complication of pelvic inflammatory disease) is infection of the fallopian tubes and the morbidity associated with it has major health implications. We are reporting a case of pyosalpinges diagnosed after hysterosalpingography and managed by laparoscopic surgery at the Douala General Hospital, Cameroon. Case presentation: A 29-year-old single woman, an assistant nurse of the Douala tribe in Cameroon. She is G1P0010 and came to our attention because of secondary infertility of three years duration...
2018: Fertility Research and Practice
https://www.readbyqxmd.com/read/29684347/developmental-endothelial-locus-1-prevents-development-of-peritoneal-adhesions-in-mice
#14
Yan Fu, Jiaywei Tsauo, Yucheng Sun, Zhe Wang, Kun Yung Kim, Seung-Hwan Lee, Dong-Young Kim, Feifeng Jing, Dahae Lim, Ho-Young Song, Hoon Hyun, Eun Young Choi
Postoperative peritoneal adhesions, fibrous bands formed in the peritoneal cavity following surgery, represent a common, challenging and costly problem faced by surgeons and patients, for which effective therapeutic options are lacking. Since aberrant inflammation is one of the key mechanisms underlying peritoneal adhesion formation, here we set out to study the role of developmental endothelial locus-1 (Del-1), which has been recently identified as an endogenous inhibitor of inflammation, in the formation of postoperative peritoneal adhesions using a mouse model of peritoneal adhesions induced by ischemic buttons...
April 24, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29684118/spontaneous-endometriosis-in-cynomolgus-monkeys-as-a-clinically-relevant-experimental-model
#15
A Nishimoto-Kakiuchi, S Netsu, S Okabayashi, K Taniguchi, H Tanimura, A Kato, M Suzuki, T Sankai, R Konno
STUDY QUESTION: Does spontaneous endometriosis in cynomolgus monkeys have the characteristics required of a good experimental model? SUMMARY ANSWER: Spontaneous endometriosis in cynomolgus monkeys exhibited similar clinicopathological characteristics to the human disease and was useful as an experimental model. WHAT IS KNOWN ALREADY: The prevalence of endometriosis in autopsied cynomolgus monkeys (Macaca fascicularis) in a breeding colony was reported to be 28...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29682387/surgical-management-of-encapsulating-peritoneal-sclerosis-a-case-report-in-kidney-transplant-patient
#16
R Shahbazov, M Talanian, J L Alejo, F Azari, A Agarwal, K L Brayman
Introduction: Encapsulating peritoneal sclerosis (EPS) is a clinical syndrome of progressive fibrotic change in response to prolonged, repetitive, and typically severe insult to the peritoneal mesothelium, often occurring in the setting of peritoneal dialysis (PD). Clear guidelines for successful management remain elusive. We describe the successful surgical management of EPS in a 28-year-old male s/p deceased donor kidney transplant for end-stage renal disease (ESRD) secondary to focal segmental glomerulosclerosis (FSGS)...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29682057/silent-migration-of-ventriculoperitoneal-shunt-per-anus-in-a-child-management-and-review-of-literature
#17
Sachin Parshuram Guthe, Survashe Pravin, Poonam Darade, Vernon Velho
The aim of this paper is to report a case of ventriculoperitoneal (VP) shunt tube coming out through the anus in a 6-year-old boy, who had undergone shunt revision surgery for the malfunctioning of the peritoneal end 6 months back. Among the complications of VP shunt surgery, such unusual migration of peritoneal end of the VP shunt is very rare. The possible factors responsible for this complication, in our case, were abdominal adhesions and thin bowel wall in the children. Although this complication has been previously reported, it remains an exceedingly rare case...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29668612/treatment-by-ultrasound-guided-local-infiltration-in-adhesion-related-abdominal-pain-and-intractable-hiccups-a-case-report
#18
Dan Zhu, Zhi-Yong Gu, Chia-Shiang Lin, Fa-Chuan Nie, Jian Cui
RATIONALE: Abdominal pain and hiccups secondary to intra-abdominal adhesion are surgical complications that are often treated by painkillers and secondary surgeries with an unsatisfactory therapeutic effect. This study presents a new treatment method that uses ultrasound-guided local infiltration in peritoneal and abdominal wall adhesions in patients with hiccups and abdominal pain. PATIENT CONCERNS: A 62-year-old patient presented to our hospital with a history of intractable hiccups and abdominal pain for 30 years...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667907/direct-peritoneal-resuscitation-reduces-leukocyte-infiltration-in-the-kidney-after-acute-brain-death
#19
Jessica Lee Weaver, Paul J Matheson, Amy Matheson, Victoria S Graham, Cynthia Downard, Richard Neal Garrison, Jason W Smith
Brain death is associated with significant inflammation within the kidneys, which may contribute to reduced graft survival. Direct peritoneal resuscitation (DPR) has been shown to reduce systemic inflammation after brain death. To determine its effects, brain dead rats were resuscitated with normal saline (targeted intravenous fluid, TIVF) to maintain a mean arterial pressure of 80 mmHg and DPR animals also received 30cc of intraperitoneal peritoneal dialysis solution. Rats were euthanized at zero, two, four, and six hours after brain death...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29666088/transection-versus-infection-acute-appendicitis-in-a-peritoneal-dialysis-patient-presenting-as-catheter-dysfunction-and-discontinuity-on-x-ray
#20
Tatiana Thom, Deanne Leonard, Peter Fitzpatrick, Nabeel Aslam
Acute appendicitis in peritoneal dialysis patients generally presents as abdominal pain and cloudy dialysate. We report a case of acute appendicitis in a peritoneal dialysis patient that presented as poor dialysate fluid drainage and an abnormal abdominal X-ray showing breakage in the continuity of the catheter. Catheter dysfunction in this case was caused by acute appendicitis leading to the formation of adhesions with peritoneal dialysis catheter trapped in it. This resulted in radiological appearance of catheter breakage, although catheter itself was intact...
April 17, 2018: BMJ Case Reports
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