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https://www.readbyqxmd.com/read/29448806/endovascular-treatment-for-the-control-of-active-vaginal-bleeding-from-uterine-cervical-cancer-treated-with-radiotherapy
#1
Cheng Shi Chen, Sohee Park, Ji Hoon Shin, Yasir Nouri, Jong-Woo Kim, Hyun-Ki Yoon, Gi-Young Ko
Background Endovascular treatment has become a significant therapeutic option for the management of intractable bleeding in gynecologic malignancies. However, the endovascular treatment types were almost never mentioned when active bleeding from different arteries was identified. Purpose To present angiographic details and evaluate clinical efficacy of endovascular treatments to control active vaginal bleeding in uterine cervical cancer patients treated with radiotherapy. Material and Methods In this retrospective study, six, consecutive cervical cancer patients treated with radiotherapy who underwent endovascular treatment for active vaginal bleeding were included...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29447434/alterations-in-melatonin-and-serotonin-signalling-in-the-colonic-mucosa-of-mice-with-dextran-sodium-sulfate-induced-colitis
#2
Sarah J MacEachern, Catherine M Keenan, Evangelia Papakonstantinou, Keith A Sharkey, Bhavik Anil Patel
BACKGROUND AND PURPOSE: Inflammatory bowel disease (IBD) is characterized by pain, bleeding, cramping and altered gastrointestinal (GI) function. Changes in mucosal serotonin (5-HT) signalling occur in animal models of colitis and in humans suffering from IBD. Melatonin is co-released with 5-HT from the mucosa and has a wide variety of actions in the GI tract. Here we examined how melatonin signalling is affected by colitis and determined how this relates to 5-HT signalling. EXPERIMENTAL APPROACH: Using electroanalytical approaches, we investigated how 5-HT release, reuptake and availability as well as melatonin availability are altered in dextran sodium sulfate (DSS)-induced colitis in mice...
February 15, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29437719/dieulafoy-s-lesion-in-the-oesophagus-a-rare-cause-of-upper-gastrointestinal-bleeding
#3
Divyesh Reddy Nemakayala, Manoj P Rai, Julie L Yam, Heather Laird-Fick
A Dieulafoy's lesion is defined as a dilated, aberrant, submucosal artery that erodes overlying mucosa in the absence of an underlying ulcer, aneurysm or intrinsic mural abnormality. It is a rare cause of upper gastrointestinal (GI) bleed with a very high mortality rate if it goes unidentified. It is most commonly located in the lesser curvature of the stomach but is extremely rare in the oesophagus. We are reporting a 55-year-old man who had massive haematemesis. Emergent endoscopy showed Dieulafoy's lesion in the distal oesophagus...
February 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29433532/is-there-a-difference-in-bleeding-after-left-ventricular-assist-device-implant-centrifugal-versus-axial
#4
Ann C Gaffey, Carol W Chen, Jennifer J Chung, Jason Han, Christian A Bermudez, Joyce Wald, Pavan Atluri
BACKGROUND: Continuous-flow left ventricular assist devices (CF-LVAD) have become the standard of care for patients with end stage heart failure. Device reliability has increased, bringing the potential for VAD, compared to transplant, into debate. However, complications continue to limit VADs as first line therapy. Bleeding is a major morbidity. A debate exists as to the difference in bleeding profile between the major centrifugal and axial flow devices. We hypothesized that there would be similar adverse bleeding event profiles between the 2 major CF-LVADs...
February 13, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29432050/preventing-rescue-surgeries-by-endoscopic-clipping-a-valuable-resource-in-the-surgeon-toolbox
#5
Shanglei Liu, Garth R Jacobsen, Bryan J Sandler, Thomas J Savides, Syed Fehmi, Hans Fuchs, Ran B Luo, Jonathan C Delong, Alisa M Coker, Caitlin Houghton, Santiago Horgan
AIM: Over-the-scope-clip (OTSC) System is a relatively new endoluminal intervention for gastrointestinal (GI) leaks, fistulas, and bleeding. Here, we present a single center experience with the device over the course of 4 years. METHODS: Retrospective chart review was conducted for patients who received endoscopic OTSC treatment. Primary outcome is the resolution of the original indication for clip placement. Secondary outcomes are complications and time to resolution...
February 12, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29426055/the-manchester-triage-system-mts-a-score-for-emergency-management-of-patients-with-acute-gastrointestinal-bleeding
#6
Marc Nguyen-Tat, Constantin Cornelius, Arthur Hoffman, Achim Tresch, Joerg Krey, Ralf Kiesslich, Peter Robert Galle, Johannes Wilhelm Rey
BACKGROUND:  Suspected gastrointestinal (GI) bleeding is a common initial diagnosis in emergency departments. Despite existing endoscopic scores to estimate the risk of GI bleeding, the primary clinical assessment of urgency can remain challenging. The 5-step Manchester Triage System (MTS) is a validated score that is often applied for the initial assessment of patients presenting in emergency departments. METHODS:  All computer-based records of patients who were admitted between January 2014 and December 2014 to our emergency department in a tertiary referral hospital were analyzed retrospectively...
February 9, 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29420430/risk-of-recurrent-disease-and-surgery-following-an-admission-for-acute-diverticulitis
#7
Charlotte El-Sayed, Simon Radley, Jemma Mytton, Felicity Evison, Stephen T Ward
BACKGROUND: Diverticular disease accounts for significant morbidity and mortality and may take the form of recurrent episodes of acute diverticulitis. The role of elective surgery is not clearly defined. OBJECTIVE: This study aimed to define the rate of hospital admission for recurrent acute diverticulitis and risk factors associated with recurrence and surgery. DESIGN: This is a retrospective population-based cohort study. SETTINGS: National Health Service hospital admissions for acute diverticulitis in England between April 2006 and March 2011 were reviewed...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29419474/frequency-diagnosis-treatment-and-outcome-of-gastrointestinal-disease-in-granulomatosis-with-polyangiitis-and-microscopic-polyangiitis
#8
Per Eriksson, Mårten Segelmark, Olof Hallböök
OBJECTIVE: Involvement of the gastrointestinal (GI) tract is a rare complication of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). The aim was to describe frequency, diagnosis, treatment, and outcome of GI disease in a large series of patients in a single center. METHODS: A database that includes all patients with GPA and MPA diagnosed since 1997 in a defined area of southeastern Sweden as well as prevalent older cases and tertiary referral patients was screened for patients with GI disease...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29417856/gastrointestinal-safety-and-tolerability-of-oral-non-aspirin-over-the-counter-analgesics
#9
Nicholas Moore, James M Scheiman
Over-the-counter (OTC) analgesics are routinely used worldwide for self-management of various painful conditions. Despite this, there has been little in-depth review of the safety of non-aspirin analgesics at OTC doses. This paper reviews the available literature on the gastrointestinal (GI) and hepatic safety of non-aspirin OTC analgesics, including nonsteroidal anti-inflammatory drugs (NSAIDs; ibuprofen, ketoprofen, diclofenac, and naproxen) and acetaminophen; safety in overdose is also reviewed. Each non-aspirin OTC analgesic has a distinct adverse event (AE) profile, with GI AE rates for OTC dosing in one study ranging from 37% for diclofenac to 7...
February 8, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29413204/gastrointestinal-manifestations-of-autoimmune-diseases-requiring-critical-care
#10
REVIEW
Angela Collins-Yoder
Proper functioning within the gastrointestinal (GI) system is essential to immune integrity. Autoimmune diseases (ADs) can disrupt GI integrity and cause serious derangements of organ function. ADs exist on a continuum of mild to severe. Life-threatening presentations of ADs can lead to rapid clinical demise. Additionally, the medications used to control ADs can precipitate gastric bleeding and predispose patients to sepsis in critical care. AD treatment focuses on diminishing symptoms through reducing autoantibody production that leads to cytokine release...
March 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29411065/the-results-of-in-situ-prosthetic-graft-replacement-for-infected-aortic-disease
#11
Youngjin Han, Tae-Won Kwon, Sang Jun Park, Min-Jae Jeong, Kyunghak Choi, Gi-Young Ko, Sang-Oh Lee, Yong-Pil Cho
BACKGROUND: Infected aortic disease is a serious clinical condition associated with significant morbidity and mortality. This study reviewed the outcomes of in situ aortic replacement with a prosthetic graft for infected aortic disease, including primary infected abdominal aortic aneurysms (PIAAA), infected aortic prosthetic grafts (IAPG), and infected aortic stent grafts (IASG). METHODS: Twenty-eight consecutive patients who underwent in situ aortic replacement with a prosthetic graft for PIAAA, IAPG, and IASG at a single center from January 2001 to December 2015 were retrospectively analyzed...
February 6, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29407494/which-orthodontic-appliance-is-best-for-oral-hygiene-a-randomized-clinical-trial
#12
Aditya Chhibber, Sachin Agarwal, Sumit Yadav, Chia-Ling Kuo, Madhur Upadhyay
INTRODUCTION: Clear aligners and to a lesser extent self-ligated brackets are considered to facilitate better oral hygiene than traditional fixed orthodontic appliances. This 3-arm parallel-group prospective randomized clinical trial compared the long-term and short-term effects of clear aligners, self-ligated brackets, and conventional (elastomeric-ligated) brackets on patients' oral hygiene during active orthodontic treatment. METHODS: Seventy-one participants (41 boys, 30 girls; mean age, 15...
February 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29398858/a-comparative-evaluation-of-the-efficacy-of-curcumin-and-chlorhexidine-mouthrinses-on-clinical-inflammatory-parameters-of-gingivitis-a-double-blinded-randomized-controlled-clinical-study
#13
Anirban Chatterjee, Koel Debnath, Nagabhushan Koratagere Hanumanta Rao
Aim: The aim of this study was to assess the efficacy of 0.1% curcumin mouthwash and to compare it with 0.2% chlorhexidine gluconate as an antiplaque agent and its effect on gingival inflammation. Materials and Methods: One hundred and fifty subjects, age between 20 and 30 years were recruited. Study population were randomly divided into three groups. In Group A, 50 subjects were advised the experimental mouthwash. Group B subjects used placebo mouthrinse, and chlorhexidine mouth wash was given to Group C...
March 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29390545/rare-upper-gastrointestinal-hemorrhage-of-cetuximab-a-case-report
#14
Shi-Jie Duan, Zi-Ming Gao, Peng-Liang Wang, Bao-Cheng Gong, Han-Wei Huang, Lei Luo, Xin Wang, Ya-Nan Xing, Hui-Mian Xu, Fu-Nan Liu
RATIONALE: cetuximab, an epidermal growth factor receptor inhibitor, is a targeted therapeutic regimen of colorectal cancers. Several common adverse effects have been found, such as cutaneous or gastrointestinal toxicity. However, according to the articles had been published, upper gastrointestinal bleeding (UGIB) is considered to be rare and its mechanism remains unclear. PATIENT CONCERNS: In this report, we presented a 42-year-old male patient with advanced recto-sigmoid cancer...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384923/emergency-transcatheter-arterial-embolization-for-massive-gastrointestinal-arterial-hemorrhage
#15
Zhong Xing Shi, Jing Yang, Hong Wei Liang, Zhen Hua Cai, Bin Bai
To evaluate the different arteriographic manifestations of acute arterial massive hemorrhage of the gastrointestinal (GI) tract and the efficacy of emergency transcatheter arterial embolization (ETAE).A total of 88 patients with acute massive GI bleeding who experienced failure of initial endoscopy and/or conservative treatment were referred to our interventional department for acute GI arteriography from January 2007 to June 2015. After locating the source of bleeding, appropriate embolic agents, such as spring coil, hydroxyl methyl acrylic acid gelatin microspheres, polyvinyl alcohol (PVA) particles, etc...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29374489/stress-ulcer-prophylaxis-in-intensive-care-unit-patients-receiving-enteral-nutrition-a-systematic-review-and-meta-analysis
#16
Hui-Bin Huang, Wei Jiang, Chun-Yao Wang, Han-Yu Qin, Bin Du
BACKGROUND: Pharmacologic stress ulcer prophylaxis (SUP) is recommended in critically ill patients with high risk of stress-related gastrointestinal (GI) bleeding. However, as to patients receiving enteral feeding, the preventive effect of SUP is not well-known. Therefore, we performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of pharmacologic SUP in enterally fed patients on stress-related GI bleeding and other clinical outcomes. METHODS: We searched PubMed, Embase, and the Cochrane database from inception through 30 Sep 2017...
January 28, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29371284/comparative-effectiveness-of-novel-oral-anticoagulants-in-uk-patients-with-non-valvular-atrial-fibrillation-and-chronic-kidney-disease-a-matched-cohort-study
#17
Simone Y Loo, Janie Coulombe, Sophie Dell'Aniello, James M Brophy, Samy Suissa, Christel Renoux
OBJECTIVES: To evaluate the effectiveness and safety of novel oral anticoagulants (NOACs) compared with vitamin K antagonists (VKAs) among patients with non-valvular atrial fibrillation (NVAF), particularly those with chronic kidney disease (CKD). DESIGN: Population-based matched cohort study. SETTING: Over 670 primary care practices in the UK, contributing to the Clinical Practice Research Datalink. PARTICIPANTS: Up to 6818 adult patients newly treated with NOACs between 2011 and 2016, matched 1:1 to new users of VKAs on age, sex and high-dimensional propensity score...
January 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29369239/rising-events-and-improved-outcomes-of-gastrointestinal-bleed-with-shock-in-usa-a-12-year-national-analysis
#18
Nauman S Siddiqui, Suman Paul, Zubair Khan, Toseef Javaid, Syed S Hasan, Zarmina Khan, Jamal Saleh, Douglas J Federman, Sadik Khuder, Ali Nawras
OBJECTIVE: Limited information is available based on single-center studies on trends of incidence and outcomes in gastrointestinal (GI) bleed with shock. METHODS: We analyzed data from 2002 to 2013 National Inpatient Sample. Using ICD-9 codes we identified 6.4 million hospital discharges of GI bleed from National Inpatient Sample database. Events were analyzed based on type of GI bleed, in-hospital mortality, hemodynamic status, and use of blood products. RESULTS: GI bleed with shock results in higher hospital mortality (20...
January 23, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29360144/agreement-between-coding-schemas-used-to-identify-bleeding-related-hospitalizations-in-claims-analyses-of-nonvalvular-atrial-fibrillation-patients
#19
Craig I Coleman, Tatsiana Vaitsiakhovich, Elaine Nguyen, Erin R Weeda, Nitesh A Sood, Thomas J Bunz, Bernhard Schaefer, Anna-Katharina Meinecke, Daniel Eriksson
BACKGROUND: Schemas to identify bleeding-related hospitalizations in claims data differ in billing codes used and coding positions allowed. We assessed agreement across bleeding-related hospitalization coding schemas for claims analyses of nonvalvular atrial fibrillation (NVAF) patients on oral anticoagulation (OAC). HYPOTHESIS: We hypothesized that prior coding schemas used to identify bleeding-related hospitalizations in claim database studies would provide varying levels of agreement in incidence rates...
January 23, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29360138/interventions-to-reduce-acute-and-late-adverse-gastrointestinal-effects-of-pelvic-radiotherapy-for-primary-pelvic-cancers
#20
REVIEW
Theresa A Lawrie, John T Green, Mark Beresford, Linda Wedlake, Sorrel Burden, Susan E Davidson, Simon Lal, Caroline C Henson, H Jervoise N Andreyev
BACKGROUND: An increasing number of people survive cancer but a significant proportion have gastrointestinal side effects as a result of radiotherapy (RT), which impairs their quality of life (QoL). OBJECTIVES: To determine which prophylactic interventions reduce the incidence, severity or both of adverse gastrointestinal effects among adults receiving radiotherapy to treat primary pelvic cancers. SEARCH METHODS: We conducted searches of CENTRAL, MEDLINE, and Embase in September 2016 and updated them on 2 November 2017...
January 23, 2018: Cochrane Database of Systematic Reviews
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