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https://www.readbyqxmd.com/read/29215478/tranexamic-acid-for-lower-gi-hemorrhage-a-randomized-placebo-controlled-clinical-trial
#1
Stephen R Smith, David Murray, Peter G Pockney, Cino Bendinelli, Brian D Draganic, Rosemary Carroll
BACKGROUND: Lower GI hemorrhage is a common source of morbidity and mortality. Tranexamic acid is an antifibrinolytic that has been shown to reduce blood loss in a variety of clinical conditions. Information regarding the use of tranexamic acid in treating lower GI hemorrhage is lacking. OBJECTIVE: The aim of this trial was to determine the clinical efficacy of tranexamic acid when used for lower GI hemorrhage. DESIGN: This was a prospective, double-blind, placebo-controlled, randomized clinical trial...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29215411/a-novel-technique-to-measure-the-intensity-of-abnormality-on-gi-bleeding-scans-development-initial-implementation-and-correlation-with-conventional-angiography
#2
Rami Farhat, Derek T Kim, T Dustin French, Dov Bechhofer, Anca-Oana Kranz, Jason C Hoffmann
PURPOSE: Develop a technique to quantify intensity of lower gastrointestinal bleeding (LGIB) on Tc-labeled red blood cell (RBC) scintigraphy, correlate with angiography, and determine the tool's predictive value. MATERIALS AND METHODS: An IRB-approved, single institution database query of GI bleeding scans performed between January 2013 and December 2015. Reports from all studies and imaging from all positive studies were reviewed. A technique was developed for scan analysis, allowing for calculation of percent increase of activity in the region of interest (ROI, area of bleeding) and ROI in the aorta and liver (controls)...
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29212103/recurrent-diffuse-gastric-bleeding-as-a-leading-symptom-of%C3%A2-gastrointestinal-al-amyloidosis
#3
Caspar Franck, Marino Venerito, Jochen Weigt, Albert Roessner, Peter Malfertheiner
Amyloidosis is a rare disease (incidence about 0.8/100 000) characterized by extracellular tissue deposition of fibrils composed of low molecular weight subunits of a variety of serum proteins. Clinical manifestations are largely determined by the type of precursor protein, the tissue distribution and the amount of amyloid deposition. Gastrointestinal (GI) manifestations of amyloidosis are even more uncommon (3 % of all amyloidosis patients). Symptoms of GI amyloidosis are nonspecific, heterogeneous, and include weight loss, GI bleeding, heartburn, early satiety, diarrhea and abdominal pain...
December 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29207826/the-association-between-periodontal-status-serum-lipid-levels-lipoprotein-associated-phosholipase-a2-lp-pla2-in-chronic-periodontitis-subjects-and-healthy-controls
#4
Bittu Saira Koshy, Jaideep Mahendra
Introduction: Lipoprotein associated phospholipase A2 (Lp-PLA2) has been explored as a potential biomarker for Cardiovascular Disease (CVD). The human Lp-PLA2 is a serine-dependent, Ca2+- independent enzyme. It gives way to oxidised free fatty acids and lysophosphatidyl choline by hydrolysing oxidised phospholipids, that leads to smooth muscle cell apoptosis, inflammatory cell chemotaxis and endothelial cell dysfunction in CVD. Owing to its role in inflammation, it may influence the development and progression of periodontitis as well...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207774/a-diagnostic-surprise-for-a-right-iliac-fossa-mass-a-perforated-ileal-gastrointestinal-stromal-tumour
#5
J Sanjay Prakash, Anita Samraj, G Sabarish Kumar, R Vijai
Gastrointestinal Stromal Tumours (GISTs) are tumours of the gut found mostly in stomach and small intestine. The complications are Gastrointestinal (GI) bleeding, obstruction, pain and rarely perforation. We are reporting an abnormal presentation of GIST masquerading as an acute abdomen with Right Iliac Fossa (RIF) mass in 60-year-old lady. Contrast Enhanced Computed Tomography (CECT) of abdomen revealed a peripherally enhancing encapsulated abscess in RIF in close contact with base of caecum and adjacent peritonitis suggesting caecal perforation...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29201803/massive-lower-gastrointestinal-bleed-caused-by-typhoid-ulcer-conservative-management
#6
Apoorv Goel, Roli Bansal
Typhoid fever is caused by gram-negative organism Salmonella typhi. The usual presentation is high-grade fever, but complications like gastrointestinal (GI) hemorrhage and perforation are also seen frequently. With the advent of antibiotics, these complications are rarely seen now. We present a case of a young female who was admitted with a diagnosis of typhoid fever presented with a massive GI bleed from ulcers in the terminal ileum and was managed conservatively without endotherapy and surgery. How to cite this article: Goel A, Bansal R...
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29201796/hepatic-venous-pressure-gradient-measurement-in-bangladeshi-cirrhotic-patients-a-correlation-with-child-s-status-variceal-size-and-bleeding
#7
Mamun Al Mahtab, Sheikh M Noor E Alam, Mohammad A Rahim, Mohammad A Alam, Faiz A Khondaker, Ahmed L Moben, Masuda Mohsena, Sheikh Mohammad Fazle Akbar
Background: Hepatic venous pressure gradient (HVPG) reflects the portal pressure in patients with cirrhotic portal hypertension. The aim of the study was to assess the relation of HVPG to variceal size, Child-Pugh status, and variceal bleeding. Materials and methods: A total of 96 patients with cirrhosis of liver were enrolled prospectively and each patient's HVPG level was measured via the transfemoral route. Clinical and biochemical evaluation and upper gastrointestinal (GI) endoscopy were done in each subject...
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29200317/pediatric-gist-presenting-as-anemia
#8
Paola Cianci, Chiara Luini, Maddalena Marinoni, Luigi Nespoli, Alessandro Salvatoni, Silvia Salvatore
Gastrointestinal stromal tumors (GIST) are tumors of the gastrointestinal (GI) tract originating from the myenteric ganglion cells (interstitial cells of Cajal), that are very rare in children and adolescents. The most common clinical manifestation is acute or chronic, overt or occult GI bleeding although these tumors are asymptomatic in 10-30% of patients. We report a case of gastric GIST in a 11-year-old girl presenting with an iron deficiency refractory anemia without gastrointestinal symptoms and stool evidence of GI bleeding that caused a slight diagnostic delay...
December 4, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29199342/-survey-of-periodontal-health-in-medical-college-students-after-3-years-of-periodontal-health-maintenance
#9
Lin-Hua Ge, Zhi-Kai Lin, Qiu-Man Guo, Jing Ni, Jie-Lei Qian, Rong Shu
PURPOSE: To observe and evaluate the status of periodontal disease in young people and the effect of intervention to control the development of periodontal diseases. METHODS: One hundred and fifty-three medical college students were randomly divided into group A (receiving interventions) and group B (no interventions). They were followed up for 3 years. The subjects in group A received oral health education, including selection of the toothbrush, the right way to brush teeth, the use of dental floss and interdental brush...
August 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29196436/vonoprazan-prevents-low-dose-aspirin-associated-ulcer-recurrence-randomised-phase-3-study
#10
Takashi Kawai, Kazunori Oda, Nobuo Funao, Akira Nishimura, Yasushi Matsumoto, Yuji Mizokami, Kiyoshi Ashida, Kentaro Sugano
OBJECTIVE: Compare efficacy and safety of vonoprazan and lansoprazole for secondary prevention of low-dose aspirin (LDA)-associated peptic ulcers in a 24-week study and long-term extension therapy in separate study. DESIGN: Double-blind, randomised, non-inferiority study; single-blind extension study at 104 Japanese sites, including 621 patients (439 in extension) with a history of peptic ulcers who required long-term LDA therapy. Randomised (1:1:1, computer generated) patients received lansoprazole 15 mg (n=217), vonoprazan 10 mg (n=202) or vonoprazan 20 mg (n=202) once daily for 24 weeks (double blind) and ≤2 years (extension)...
December 1, 2017: Gut
https://www.readbyqxmd.com/read/29185198/metastatic-renal-cell-carcinoma-to-the-small-bowel-three-cases-of-gi-bleeding-and-a-literature-review
#11
Jessica L Mueller, Richard A Guyer, Joel T Adler, John T Mullen
Approximately 25-30% of patients with renal cell carcinoma (RCC) have metastatic disease at the time of diagnosis, where the most common sites of metastasis are the lung (50-60% of patients with metastatic disease), bones (30-40%), liver (30-40%), and brain (5%). Although RCC metastasis to the small intestine is thought to be exceedingly rare, with predominantly isolated case reports and a few case series in the literature, we present below three additional cases at our institution of metastatic RCC to the small bowel presenting as GI bleeding...
November 28, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29178717/the-influence-of-the-utilization-time-of-brush-heads-from-different-types-of-power-toothbrushes-on-oral-hygiene-assessed-over-a-6-month-observation-period-a-randomized-clinical-trial
#12
Jan Schmickler, Sabine Wurbs, Susanne Wurbs, Katharina Kramer, Sven Rinke, Else Hornecker, Rainer F Mausberg, Dirk Ziebolz
PURPOSE: This randomized clinical trial investigated the influence of the utilization time of brush heads from different types of power toothbrushes [oscillating rotating (OR) and sonic action (SA)93; on oral hygiene (plaque accumulation and gingival inflammation) over a 6-month observation period. METHODS: 49 participants were randomly allocated into two groups: use of the same brush head over 6 months (NR: non-replacement) or replacement of brush head every 4 weeks over 6 months (R: replacement)...
December 2016: American Journal of Dentistry
https://www.readbyqxmd.com/read/29176321/clinical-characteristics-and-prognostic-factors-of-small-intestine-angiosarcoma-a-retrospective-clinical-analysis-of-66-cases
#13
Rong Li, Ze-Ying Ouyang, Jun-Bo Xiao, Jian He, Yan-Wu Zhou, Gui-Ying Zhang, Qian Li, Huan Gu, Ai-Min Leng, Ting Liu
BACKGROUND/AIMS: Primary angiosarcoma of the small intestine is a rare neoplasia, and there are limited data from systematic analyses. The aim of this study is to describe the clinical and pathological characteristics in addition to the prognostic factors for this rare neoplasia. METHODS: We retrospectively collected the clinical records and prognostic information of 66 patients with small intestine angiosarcoma reported between 1970 and 2017. We used the Chi-square test, the log-rank test, and Cox regression analyses to evaluate the data...
November 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29165995/magnetic-particle-imaging-for-highly-sensitive-quantitative-and-safe-in-vivo-gut-bleed-detection-in-a-murine-model
#14
Elaine Y Yu, Prashant Chandrasekharan, Ran Berzon, Zhi Wei Tay, Xinyi Y Zhou, Amit P Khandhar, R Matthew Ferguson, Scott J Kemp, Bo Zheng, Patrick W Goodwill, Michael F Wendland, Kannan M Krishnan, Spencer Behr, Jonathan Carter, Steven M Conolly
Gastrointestinal (GI) bleeding causes more than 300,000 hospitalizations per year in the United States. Imaging plays a crucial role in accurately locating the source of the bleed for timely intervention. Magnetic Particle Imaging (MPI) is an emerging clinically translatable imaging modality that images superparamagnetic iron-oxide (SPIO) tracers with extraordinary contrast and sensitivity. This linearly quantitative modality has zero background tissue signal and zero signal depth attenuation. MPI is also safe: there is zero ionizing radiation exposure to the patient and clinically approved tracers can be used with MPI...
November 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/29163963/capsule-endoscopy-in-young-patients-with-iron-deficiency-anaemia-and-negative-bidirectional-gastrointestinal-endoscopy
#15
Diana E Yung, Emanuele Rondonotti, Andry Giannakou, Tomer Avni, Bruno Rosa, Ervin Toth, Alfredo J Lucendo, Reena Sidhu, Hanneke Beaumont, Pierre Ellul, Lucian Negreanu, Victoria Alejandra Jiménez-Garcia, Deidre McNamara, Uri Kopylov, Luca Elli, Konstantinos Triantafyllou, Fahmi Shibli, Maria Elena Riccioni, Mauro Bruno, Xavier Dray, John N Plevris, A Koulaouzidis, Federico Argüelles-Arias, Aymeric Becq, Federica Branchi, María Ángeles Tejero-Bustos, Jose Cotter, Rami Eliakim, Francesca Ferretti, Ian M Gralnek, Juan Manuel Herrerias-Gutierrez, Mary Hussey, Maarten Jacobs, Gabriele Wurm Johansson, Mark McAlindon, Sara Montiero, Artur Nemeth, Marco Pennazio, Deepa Rattehalli, Ana Stemate, Annalisa Tortora, Georgios Tziatzios
Background: Recent data imply young patients (age ≤50 years) undergoing small-bowel (SB) capsule endoscopy (CE) for iron deficiency anaemia (IDA) show higher diagnostic yield (DY) for sinister pathology. We aimed to investigate DY of CE in a large cohort of young IDA patients, and evaluate factors predicting significant SB pathology. Materials and methods: This was a retrospective, multicentre study (2010-2015) in consecutive, young patients (≤50 years) from 18 centres/12 countries, with negative bidirectional gastrointestinal (GI) endoscopy undergoing SBCE for IDA...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29158179/prognostic-factors-affecting-outcomes-in-patients-with-malignant-gi-bleeding-treated-with-a-novel-endoscopically-delivered-hemostatic-powder
#16
Rapat Pittayanon, Rungsun Rerknimitr, Alan Barkun
BACKGROUND AND AIM: Endoscopic hemostatic techniques remain poorly effective for GI tumor bleeding. We assessed Tc-325 (Hemospray) for this indication and determined possible predictors of decreased recurrent bleeding and improved 6-month survival in affected patients. METHODS: This retrospective study identified 99 patients with active malignant GI bleeding (primary or metastatic) treated with Tc-325. Eleven patients were excluded because of incomplete data. Data on patient characteristics and possible predictive factors of early (72-hour) and delayed (7, 14 and 30-day) recurrent bleeding, as well as six-month survival, were collected...
November 17, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29158178/dissection-enabled-scaffold-assisted-resection-descar-a-novel-technique-for-resection-of-residual-or-non-lifting-gi-neoplasia-of-the-colon-with-video
#17
Matthew W Stier, Christopher G Chapman, Allie Kreitman, John A Hart, Shu-Yuan Xiao, Uzma D Siddiqui, Irving Waxman
BACKGROUND AND AIMS: Due to previous manipulation or submucosal invasion, GI lesions referred for endoscopic mucosal resection (EMR) frequently have flat areas of visible tissue that cannot be snared. Current methods for treating residual tissue may lead to incomplete eradication or not allow complete tissue sampling for histologic evaluation. Our aim is to describe dissection-enabled scaffold-assisted resection (DeSCAR), a new technique combining circumferential ESD with EMR for removal of superficial non-lifting or residual "islands" with suspected submucosal involvement/fibrosis...
November 17, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29149927/gastrointestinal-involvement-in-beh%C3%A3-et-disease
#18
REVIEW
Ibrahim Hatemi, Gulen Hatemi, Aykut Ferhat Çelik
Behçet disease (BD) is a variable vessel vasculitis that can involve several organs and systems. Gastrointestinal (GI) involvement has an acute exacerbating course with ulcers, most commonly in the ileocolonic area. These ulcers can be large and deep, causing perforation and massive bleeding. This article highlights the current knowledge on the epidemiology, clinical findings, diagnosis, and management of GI involvement of BD, with emphasis on recent findings.
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29141860/multicenter-evaluation-of-octreotide-as-secondary-prophylaxis-in-patients-with-left-ventricular-assist-devices-and-gastrointestinal-bleeding
#19
MULTICENTER STUDY
Keyur B Shah, Sampath Gunda, Sitaramesh Emani, Manreet K Kanwar, Nir Uriel, Paolo C Colombo, Patricia A Uber, Melissa L Sears, Joyce Chuang, David J Farrar, Donald F Brophy, George B Smallfield
BACKGROUND: Gastrointestinal (GI) bleeding is one of the most common complications after continuous-flow left ventricular assist device implantation. More than one third of patients with incident bleed go on to develop recurrent GI bleeding. Octreotide, a somatostatin analog, is proposed to reduce the risk of recurrent GI bleeding in this population. METHODS AND RESULTS: This multicenter, retrospective analysis evaluated 51 continuous-flow left ventricular assist device patients who received secondary prophylaxis with octreotide after their index GI bleed from 2009 to 2015...
November 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29139310/pudendal-nerve-injury-impairs-anorectal-function-and-health-related-quality-of-life-measures-%C3%A2-2-years-after-3d-conformal-radiotherapy-for-prostate-cancer
#20
Eng Eric Yeoh, Rochelle Botten, Addolorata Di Matteo, Marcus Tippett, Jonathon Hutton, Robert Fraser, Phillip G Dinning, David Wattchow
PURPOSE: To compare GI symptoms, measures of generic and disease specific health related quality of life (HRQoL), anorectal and pudendal nerve function and anal sphincter morphology between (i) patients ≥2 years after 3D conformal radiotherapy (3D-CRT)±high dose rate (HDR) brachytherapy for carcinoma of the prostate and aged matched patients before radiotherapy and (ii) symptomatic and asymptomatic patients ≥2 years after 3D-CRT ± HDR brachytherapy. MATERIAL AND METHODS: Methodology included: (i) modified LENT-SOMA scales for GI symptoms, (ii) EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires for generic and disease specific HRQoL, (iii) anorectal manometry and terminal motor latency for anorectal and pudendal nerve function and (iv) endorectal ultrasound for anal sphincter morphology...
November 15, 2017: Acta Oncologica
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