Moran Amit, Erez Baruch, Priyadahrshini Nagarajan, Frederico Gleber-Netto, Xiayu Rao, Tongxin Xie, Shamima Akhter, Adebayo Adewale, Shajedul Islam, Brandi Mattson, Renata Ferrarotto, Michael Wong, Michael Davies, Sonali Jindal, Sreyashi Basu, Catherine Harwood, Irene Leigh, Nadim Ajami, Andrew Futreal, Micah Castillo, Preethi Gunarante, Ryan Goepfert, Nikhil Khushalani, Jing Wang, Stephanie Watowich, George Calin, Michael Migden, Paola Vermeer, Nisha D'Silva, Dan Yaniv, Jared Burks, Javier Gomez, Patrick Dougherty, Kenneth Tsai, James Allison, Padmanee Sharma, Jennifer Wargo, Jeffrey Myers, Neil Gross
While the nervous system has reciprocal interactions with both cancer and the immune system, little is known about the potential role of tumor associated nerves (TANs) in modulating anti-tumoral immunity. Moreover, while peri-neural invasion is a well establish poor prognostic factor across cancer types, the mechanisms driving this clinical effect remain unknown. Here, we provide clinical and mechniastic association between TANs damage and resistance to anti-PD-1 therapy. Using electron microscopy, electrical conduction studies, and tumor samples of cutaneous squamous cell carcinoma (cSCC) patients, we showed that cancer cells can destroy myelin sheath and induce TANs degeneration...
July 18, 2023: Research Square