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https://www.readbyqxmd.com/read/29210523/activities-of-11-azaartemisinin-and-n-sulfonyl-derivatives-against-neospora-caninum-and-comparative-cytotoxicities
#1
Rozanne Harmse, Ho Ning Wong, Frans J Smit, Joachim Müller, Andrew Hemphill, David D N'Da, Richard K Haynes
Neosporosis caused by the apicomplexan parasite Neospora caninum is an economically important disease that induces abortion in dairy and beef cattle. There are no vaccines or drugs available on the market for control or treatment of the disease in bovines. The peroxide artemisinin and its derivatives used clinically for treatment of malaria are active against N. caninum and other apicomplexan parasites. We have now evaluated the activities of the readily accessible and chemically robust 11-azaartemisinin 5 and selected N-sulfonyl derivatives prepared as described in the accompanying paper against N...
December 6, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29209571/complete-regression-of-cutaneous-metastases-with-systemic-immune-response-in-a-patient-with-triple-negative-breast-cancer-receiving-p53mva-vaccine-with-pembrolizumab
#2
Yuan Yuan, Ferdynand J Kos, Ting-Fang He, Hongwei H Yin, Mengsha Li, Nicola Hardwick, Kathryn Zurcher, Daniel Schmolze, Peter Lee, Raju K Pillai, Vincent Chung, Don J Diamond
A heavily pretreated patient with triple negative breast cancer distinguished by cutaneous metastases received p53MVA vaccine in combination with pembrolizumab. Her cutaneous metastases regressed and after 2 cycles of therapy, a skin biopsy showed a complete pathological response. Systemic response was confirmed with restaging CT and bone scans. Activation of p53-specific T cell responses and elevation of multiple immune response genes in peripheral blood correlated with the rapid clinical response which lasted for 6 months after the initiation of combined therapy...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29207606/combination-therapy-with-an-ox40l-fusion-protein-and-a-vaccine-targeting-the-transcription-factor-twist-inhibits-metastasis-in-a-murine-model-of-breast-cancer
#3
Anthony S Malamas, Scott A Hammond, Jeffrey Schlom, James W Hodge
OX40 is a costimulatory receptor that potentiates proliferation, survival, memory formation, and effector function of CD4+ and CD8+ T-cells, while overcoming the suppressive activity of regulatory T-cells (Tregs). Here, we explored the combination of an OX40L fusion protein (OX40L-FP) with a poxvirus-based cancer vaccine (MVA-Twist-TRICOM) to inhibit tumor metastasis in the 4T1 murine breast cancer model. Contrary to the single agent treatments, the combination therapy significantly decreased the number of metastatic colonies per lung and prolonged survival...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163540/local-high-dose-radiotherapy-induces-systemic-immunomodulating-effects-of-potential-therapeutic-relevance-in-oligometastatic-breast-cancer
#4
Elena Muraro, Carlo Furlan, Michele Avanzo, Debora Martorelli, Elisa Comaro, Aurora Rizzo, Damiana A Fae', Massimiliano Berretta, Loredana Militello, Alessandro Del Conte, Simon Spazzapan, Riccardo Dolcetti, Marco Trovo'
Local irradiation of cancer through radiotherapy can induce spontaneous regression of non-directly irradiated lesions, suggesting the involvement of systemic antitumor immune responses. In oligometastatic breast cancer (BC) patients, the use of stereotactic body radiotherapy (SBRT) favors the local control of treated lesions and may contribute to break local tolerance and release tumor-associated antigens (TAAs), improving host antitumor immunity. We performed a detailed immunomonitoring of BC patients undergoing SBRT to verify its ability to "switch on" the anti-tumor immunity both systemically, in peripheral blood, and locally, employing in vitro BC models...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29157306/a-pilot-study-of-the-immunogenicity-of-a-9-peptide-breast-cancer-vaccine-plus-poly-iclc-in-early-stage-breast-cancer
#5
Patrick M Dillon, Gina R Petroni, Mark E Smolkin, David R Brenin, Kimberly A Chianese-Bullock, Kelly T Smith, Walter C Olson, Ibrahim S Fanous, Carmel J Nail, Christiana M Brenin, Emily H Hall, Craig L Slingluff
BACKGROUND: Breast cancer remains a leading cause of cancer death worldwide. There is evidence that immunotherapy may play a role in the eradication of residual disease. Peptide vaccines for immunotherapy are capable of durable immune memory, but vaccines alone have shown sparse clinical activity against breast cancer to date. Toll-like receptor (TLR) agonists and helper peptides are excellent adjuvants for vaccine immunotherapy and they are examined in this human clinical trial. METHODS: A vaccine consisting of 9 MHC class I-restricted breast cancer-associated peptides (from MAGE-A1, -A3, and -A10, CEA, NY-ESO-1, and HER2 proteins) was combined with a TLR3 agonist, poly-ICLC, along with a helper peptide derived from tetanus toxoid...
November 21, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29152681/trichothecenes-immunomodulatory-effects-mechanisms-and-anti-cancer-potential
#6
REVIEW
Qinghua Wu, Xu Wang, Eugenie Nepovimova, Anca Miron, Qianying Liu, Yun Wang, Dongxiao Su, Hualin Yang, Li Li, Kamil Kuca
Paradoxically, trichothecenes have both immunosuppressive and immunostimulatory effects. The underlying mechanisms have not been fully explored. Early studies show that dose, exposure timing, and the time at which immune function is assessed influence whether trichothecenes act in an immunosuppressive or immunostimulatory fashion. Recent studies suggest that the immunomodulatory function of trichothecenes is also actively shaped by competing cell-survival and death-signaling pathways. Autophagy may also promote trichothecene immunosuppression, although the mechanism may be complicated...
November 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29125981/the-clinical-development-of-vaccines-for-her2-breast-cancer-current-landscape-and-future-perspectives
#7
REVIEW
R L B Costa, H Soliman, B J Czerniecki
Human epidermal growth factor receptor 2 (HER2) is a tumor associated antigen over-expressed in 20-30% of cases of breast cancer. Passive immune therapy with HER2-directed monoclonal antibodies (mabs) has changed the natural history of this subset of breast tumors both in the localized and metastatic settings. The safety and efficacy of HER2 vaccines have been assessed in early phase clinical trials but to date clinically relevant results in late phase trials remain an elusive target. Here, we review the recent translational discoveries related to the interactions between the adaptive immune system and the HER2 antigen in breast cancer, results of published clinical trials, and future directions in the field of HER2 vaccine treatment development...
December 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29121792/are-you-covered-associations-between-patient-protection-and-affordable-care-act-knowledge-and-preventive-reproductive-service-use
#8
Ashlee N Sawyer, Melissa A Kwitowski, Eric G Benotsch
PURPOSE: Sexual and reproductive health conditions (eg, infections, cancers) represent public health concerns for American women. The present study examined how knowledge of the Patient Protection and Affordable Care Act (PPACA) relates to receipt of preventive reproductive health services among women. DESIGN: Cross-sectional online survey. SETTING: Online questionnaires were completed via Amazon Mechanical Turk, a crowdsourcing website where individuals complete web-based tasks for compensation...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29112895/polyactin-a-is-a-novel-and-potent-immunological-adjuvant-for-peptide-based-cancer-vaccine
#9
Wei Wang, Yanqin Li, Yawen Wang, Shuting Ren, Yiping Li, Bing Wang
Synthetic peptide cancer vaccines are poorly immunogenic sub-unit vaccines and thus essentially need adjuvants in their formulations to increase the efficacy by enhancing the peptide-specific immune response. However, aluminum-based compounds are almost dependent for clinical use at present. Therefore, the increasing use of peptide-based vaccines makes the need for novel and potent adjuvants. Polyactin A (PAA) has been used for the clinical treatment of impaired immunity in China for over 30years. To figure out the adjuvant effects of PAA for E75 peptide breast cancer vaccine (Her2 p369-p377), the generation of mature dendritic cells (DCs) from peripheral blood monocytes (PBMCs) cultured with PAA, IL-4 and TNF-α was assessed by morphologic features and the expressions of special surface markers using flow cytometry...
November 4, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29093010/targeting-retired-antigens-for-cancer-immunoprevention
#10
EDITORIAL
Robert H Shoemaker, Thomas G Forsthuber
Identification of immune targets for cancer immunoprevention, or immunotherapy, has historically focused on tumor-associated (self) antigens or neoantigens expressed on malignant cells. For self-antigens, overcoming tolerance can be a difficult challenge. Neoantigens do not suffer from this limitation, but the lack of recurrent mutations yielding common neoantigens that can be exploited in vaccines is a problem for many tumor types. Targeting "retired antigens," a specialized type of self-antigen, may have considerable advantages...
November 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29081765/breast-cancer-vaccines-new-insights
#11
REVIEW
Rosaria Benedetti, Carmela Dell'Aversana, Cristina Giorgio, Roberta Astorri, Lucia Altucci
Breast cancer (BC) is a persistent global challenge for its high frequency in women (although it seldom occurs in men), due to the large diffusion of risk factors and gene mutations, and for its peculiar biology and microenvironment. To date, BC can benefit from different therapeutic strategies involving surgery, ablation, chemotherapy, radiotherapy, and more specific approaches such as hormone therapy and the administration of various substances impairing cancer growth, aggressivity, and recurrence with different modalities...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29074302/endogenous-antibody-responses-to-mucin-1-in-a-large-multiethnic-cohort-of-patients-with-breast-cancer-and-healthy-controls-role-of-immunoglobulin-and-fc%C3%AE-receptor-genes
#12
Janardan P Pandey, Aryan M Namboodiri, Bethany Wolf, Motoki Iwasaki, Yoshio Kasuga, Gerson S Hamada, Shoichiro Tsugane
High levels of naturally occurring IgG antibodies to mucin 1 (MUC1), a membrane-bound glycoprotein that is overexpressed in patients with breast cancer, are associated with good prognosis. This suggests that endogenous anti-MUC1 antibodies have a protective effect and, through antibody-mediated host immunosurveillance mechanisms, might contribute to a cancer-free state. To test this possibility, we characterized a large number of multiethnic patients with breast cancer and matched controls for IgG antibodies to MUC1...
October 18, 2017: Immunobiology
https://www.readbyqxmd.com/read/29071810/cancer-registry-follow-up-for-17%C3%A2-million-person-years-of-a-nationwide-maternity-cohort
#13
Matti Lehtinen, Heljä-Marja Surcel, Kari Natunen, Eero Pukkala, Joakim Dillner
Population-based Finnish Maternity Cohort (FMC) comprises 2M first trimester sera collected from 1M women during 33 years. Informed consent is by the opt-out principle, and linkages with cancer and population registries provide a base for over time and over generation studies. Follow-up for 17M person-years by the end of 2014 can identify 39,700 cases of invasive cancer and 18,900 cases of premalignant breast and cervix lesions, and basal cell carcinoma diagnosed after serum sampling. For women with multiple pregnancies, serial samples taken before cancer diagnosis are available...
October 25, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29063561/best-paper-selection
#14
(no author information available yet)
Daniulaityte R, Chen L, Lamy FR, Carlson RG, Thirunarayan K, Sheth A. "When 'Bad' is 'Good'": Identifying Personal Communication and Sentiment in Drug-Related Tweets. JMIR Public Health Surveill 2016 Oct 24;2(2):e162 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099500/ Freedman RA, Viswanath K, Vaz-Luis I, Keating NL. Learning from social media: utilizing advanced data extraction techniques to understand barriers to breast cancer treatment. Breast Cancer Res Treat 2016 Jul;158(2):395-405 https://www.ncbi.nlm...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29045460/conjugated-nanoliposome-with-the-her2-neu-derived-peptide-gp2-as-an-effective-vaccine-against-breast-cancer-in-mice-xenograft-model
#15
Atefeh Razazan, Javad Behravan, Atefeh Arab, Nastaran Barati, Leila Arabi, Zahra Gholizadeh, Mahdi Hatamipour, Amin Reza Nikpoor, Amir Abbas Momtazi-Borojeni, Fatemeh Mosaffa, Mohamad Hosein Ghahremani, Mahmoud Reza Jaafari
One of the challenging issues in vaccine development is peptide and adjuvant delivery into target cells. In this study, we developed a vaccine and therapeutic delivery system to increase cytotoxic T lymphocyte (CTL) response against a breast cancer model overexpressing HER2/neu. Gp2, a HER2/neu-derived peptide, was conjugated to Maleimide-mPEG2000-DSPE micelles and post inserted into liposomes composed of DMPC, DMPG phospholipids, and fusogenic lipid dioleoylphosphatidylethanolamine (DOPE) containing monophosphoryl lipid A (MPL) adjuvant (DMPC-DMPG-DOPE-MPL-Gp2)...
2017: PloS One
https://www.readbyqxmd.com/read/29034866/the-health-effects-of-aluminum-exposure
#16
Katrin Klotz, Wobbeke Weistenhöfer, Frauke Neff, Andrea Hartwig, Christoph van Thriel, Hans Drexler
BACKGROUND: Aluminum is regularly taken up with the daily diet. It is also used in antiperspirants, as an adjuvant for vaccination, and in desensitization procedures. In this review, we present the scientifically documented harmful effects of aluminum on health and the threshold values associated with them. METHODS: This review is based on publications retrieved by a selective search of the PubMed and SCOPUS databases on the topic of aluminum in connection with neurotoxicity, Alzheimer's disease, and breast cancer, as well as on the authors' personal experience in occupational and environmental medicine...
September 29, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29034685/improving-performance-on-preventive-health-quality-measures-using-clinical-decision-support-to-capture-care-done-elsewhere-and-patient-exceptions
#17
Michael E Bowen, Deepa Bhat, Jason Fish, Brett Moran, Temple Howell-Stampley, Lynne Kirk, Stephen D Persell, Ethan A Halm
Preventive services required for performance measurement often are completed in outside health systems and not captured in electronic medical records (EMRs). A before-after study was conducted to examine the ability of clinical decision support (CDS) to improve performance on preventive quality measures, capture clinician-reported services completed elsewhere, and patient/medical exceptions and to describe their impact on quality measurement. CDS improved performance on colorectal cancer screening, osteoporosis screening, and pneumococcal vaccination measures ( P < ...
October 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28972792/a-nano-liposome-vaccine-carrying-e75-a-her-2-neu-derived-peptide-exhibits-significant-anti-tumor-activity-in-mice
#18
Atefeh Arab, Javad Behravan, Atefeh Razazan, Zahra Gholizadeh, Amin Reza Nikpoor, Nastaran Barati, Fatemeh Mosaffa, Ali Badiee, Mahmoud Reza Jaafari
E75 (HER-2/neu-369-377), is an immunogenic peptide which is highly expressed in breast cancer patients. The purpose of this study was to develop an effective vaccine delivery/adjuvant system by attachment of this peptide to the surface of liposomes consisting of phospholipids including DSPC and DSPG with high transition temperature (Tm) and DOPE (a pH-sensitive lipid for cytosolic antigen delivery) to improve anti-tumor immune activity against the E75 peptide. For this purpose, the E75 peptide was incorporated into liposomes consisting of DSPC/DSPG/Chol/DOPE (15/2/3/5 molar ratio) through conjugation with maleimide-PEG2000-DSPE...
October 3, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28951858/a-survey-of-osteoporosis-and-breast-cancer-risk-perception-among-menopausal-and-postmenopausal-women-in-hong-kong
#19
Louis Wc Chow, Michael Mc Cheung, Jennifer Wj Chu, Ivy Cf Li
OBJECTIVES: A lack of understanding in menopausal and postmenopausal women's (PMW) risk perception towards osteoporosis and breast cancer still exists, which is explored in this study. This information might allow health professionals to conduct interventions to improve health behaviors before menopause-related diseases are imminent. METHODS: Between 10 December 2015 and 31 January 2016, 573 menopausal or PMW were successfully interviewed on 17 questions, comprising separate sections for osteoporosis and breast cancer...
August 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28945501/associations-between-sexual-orientation-and-overall-and-site-specific-diagnosis-of-cancer-evidence-from-two-national-patient-surveys-in-england
#20
Catherine L Saunders, Catherine Meads, Gary A Abel, Georgios Lyratzopoulos
Purpose To address gaps in evidence on the risk of cancer in people from sexual minorities. Patients and Methods We used data from 796,594 population-based English General Practice Patient Survey responders to explore the prevalence of self-reported diagnoses of cancer in the last 5 years among sexual minorities compared with heterosexual women and men. We analyzed data from 249,010 hospital-based English Cancer Patient Experience Survey responders with sexual orientation as a binary outcome, and International Classification of Diseases, Tenth, Revision, diagnosis as covariate-38 different common and rarer cancers, with breast and prostate cancer as baseline categories for women and men, respectively-to examine whether people from sexual minorities are over- or under-represented among different cancer sites...
November 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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