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Congcong Sun, Wen Xia, Ying Liu, Guoyong Jia, Cuilan Wang, Chuanzhu Yan, Yi Li
RATIONALE: Fatal familial insomnia (FFI) linked to a D178N/129M haplotype mutation in the PRNP gene is the most common genetic prion disease in the Han Chinese population. Here, we describe a Han Chinese patient with FFI who exhibited agrypnia excitata and obstructive apnea. PATIENT CONCERNS: A 46-year-old man displayed involuntary movements during sleep time, snoring, autonomic nervous system dysfunction, cognitive deficit, brainstem symptoms, myoclonus and ataxia in order within 8 months...
December 2017: Medicine (Baltimore)
Ivana Kacirova, Milan Grundmann, Petr Silhan, Hana Brozmanova
Clonazepam is long-acting benzodiazepine agonist used in short-acting benzodiazepine withdrawal; however, recent observations suggest the existence of its abuse. We demonstrate a 40-year-old man with a 20-year history of psychiatric care with recently benzodiazepine dependence (daily intake of ∼60 mg of clonazepam and 10 mg of alprazolam). High serum levels of both drugs were analyzed 3 weeks before admission to hospitalization (clonazepam 543.9 ng/mL, alprazolam 110 ng/mL) and at the time of admission (clonazepam 286...
March 2016: Medicine (Baltimore)
Chun-Hay Ko, Chi-Man Koon, Siu-Lung Yu, Kwok-Ying Lee, Clara Bik-San Lau, Edwin Ho-Yin Chan, Yun-Kwok Wing, Kwok-Pui Fung, Ping-Chung Leung
OBJECTIVE: To assess the biological effects of the six-herb mixture Anti-Insomia Formula (AIF) extract using caffeine-induced insomnia Drosophila model and short-sleep mutants. METHODS: Caffeineinduced insomnia wild-type Drosophila and short-sleep mutant flies minisleep (mns) and Hyperkinetic(Y) (Hk(Y)) were used to assess the hypnotic effects of the AIF in vivo. The night time activity, the amount of night time sleep and the number of sleep bouts were determined using Drosophila activity monitoring system...
May 2016: Chinese Journal of Integrative Medicine
Takeshi Sakurai
Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for maintenance of wakefulness. This review discusses animal models of narcolepsy; the contribution of each orexin receptor subtype to the narcoleptic phenotypes; and the etiology of orexin neuronal death. It also raises the possibility of novel therapies targeting the orexin system for sleep disorders including insomia and narcolepsy-cataplexy...
October 2013: Current Opinion in Neurobiology
Zhaoyang Huang, Shuqin Zhan, Ning Li, Yan Ding, Yuping Wang
Neurobiological correlates underlying insomnia are poorly understood. The hyperarousal of the central nervous system indicates that cortical excitability may be abnormal in patients with insomnia. The purpose of the present study was to investigate changes in cortical excitability by examining the recovery function of median nerve somatosensory evoked potentials (SEPs) in patients with primary insomia (PI). We studied the recovery function of median nerve SEPs in 12 medication-naive PI patients and in 12 age- and sex-matched healthy subjects...
August 15, 2012: Psychiatry Research
Małgorzata Zychlińska, Antoni Florkowski, Alicja Furmańska, Małgorzata Dudak, Agnieszka Gajda
UNLABELLED: The popularization of biopsychosocial model allowed for broader introduction of psychological means of treatment methods, among which, a group therapy takes a special place. This form of therapy, although held in groups, focuses on helping an individual patient to recover. Neurotic disorders connected with stress and somatoform disorders are group of diseases in which symptoms like anxiety, insomia, decreased self-assessment, pessimistic thoughts reduce the level of patients' functioning...
2008: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Xu-Ning Zheng, Ling-Ju Zhang, Hui Liang, Wei Chen, Xiong-Chao Zhu, Min Yuan, Yang Liu
OBJECTIVE: To observe the change of auditory event-related potentials (P300) and sympathetic skin response (SSR) in people with insomia of Sweet Dream Capsule therapy. METHODS: 30 patients meeting criteria for primary insomnia and 30 healthy volunteers with age matching controls were selected for the study. P300 and SSR were measured before treatment of Sweet Dream Capsule and at week 4 , 8 of the therapeutic course. That the change of P300 and SSR before and after treatment and their relations with PSQI were studied...
August 2004: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Eric A Nofzinger
Models of the pathophysiology of human sleep disorders have only recently been tested using nuclear medicine assessments, which have greatly increased our understanding of the brain mechanisms involved in the human sleep-wake cycle. Dramatic changes in function have been observed in large-scale neuronal networks during sleep. Broad declines in heteromodal-association-cortical function, and relative increases in limbic and paralimbic function have been observed. These cortical areas are responsible for essential aspects of human behavior, allowing us to interact with the world around us and to evaluate the significance of important events in our lives...
June 2004: Sleep Medicine
A Takei, M Okawa, H Sasaki, T Hamada, K Tashiro
The effects of melatonin (MLT) therapy on insomnia and serum MLT concentration were studied in a 44-year-old man with Machado-Joseph disease. He suffered from insomia since age 41, and could not sleep well, despite that he was given many kinds of hypnotics. He showed neither noctural central apnea, inspirative stridor, restless leg syndrome, REM without atonia, nor noctural polyuria, all of which are known to cause insomnia in spinocerebellar degeneration. The peak serum level of MLT was low, 9.2 pg/ml. He was administered 9 mg of MLT p...
July 2000: Rinshō Shinkeigaku, Clinical Neurology
H G Preuss
No abstract text is available yet for this article.
October 22, 1965: Medizinische Klinik
M Kajihara, M Sugawa
No abstract text is available yet for this article.
September 1974: Kango Kyoshitsu. [Nursing Classroom]
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