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Liver transplant

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https://www.readbyqxmd.com/read/29150986/memory-t-cells-are-significantly-increased-in-rejecting-liver-allografts-of-rhesus-monkeys
#1
Hwajung Kim, Hyeyoung Kim, Sun-Kyung Lee, Xue-Li Jin, Tae Jin Kim, Chanho Park, Jae-Il Lee, Hyo-Sin Kim, Suk Kyun Hong, Kyung Chul Yoon, Sung Woo Ahn, Kyoung-Bun Lee, Nam-Joon Yi, Jaeseok Yang, Kwang-Woong Lee, Wayne J Hawthorne, Kyung-Suk Suh
INTRODUCTION: The Rhesus monkey (RM) is an excellent preclinical model in kidney, heart and islet transplantation that has provided the basis for new immunosuppressive protocols for clinical studies. However, there remain relatively few liver transplantation (LT) models in nonhuman primates. In this study, we analyzed the immune cell populations of PBMCs and secondary lymphoid organs along with livers of normal rhesus monkeys and compared them to those of rejecting liver transplanted recipient's following withdrawal of immunosuppression...
November 18, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29150966/current-policy-for-allocation-of-donor-livers-in-the-netherlands-advantages-primary-sclerosing-cholangitis-patients-on-the-liver-transplantation-waiting-list-a-retrospective-study
#2
Jorn C Goet, Bettina E Hansen, Madelon Tieleman, Bart van Hoek, Aad P van den Berg, Wojciech G Polak, Jeroen Dubbeld, Robert J Porte, Cynthia Konijn, Robert A de Man, Herold J Metselaar, Annemarie C de Vries
Studies from the United States and Nordic countries indicate primary sclerosing cholangitis (PSC) patients have low mortality on the liver transplantation (LTx) waiting list. However, this may vary among geographical areas. Therefore, we compared waiting list mortality and post-transplant survival between Laboratory Model for End Stage Liver Disease (LM) and MELD Exception (ME) prioritized PSC and non-PSC candidates in a nationwide study in the Netherlands. A retrospective analysis of patients waitlisted from 2006 to 2013 was conducted...
November 18, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29150810/liver-fibrosis-alleviation-after-co-transplantation-of-hematopoietic-stem-cells-with-mesenchymal-stem-cells-in-patients-with-thalassemia-major
#3
Ardeshir Ghavamzadeh, Masoud Sotoudeh, Amir Pejman Hashemi Taheri, Kamran Alimoghaddam, Hossein Pashaiefar, Mahdi Jalili, Farhad Shahi, Mohammad Jahani, Marjan Yaghmaie
The aims of this study are to determine the replacement rate of damaged hepatocytes by donor-derived cells in sex-mismatched recipient patients with thalassemia major and to determine whether co-transplantation of mesenchymal stem cells and hematopoietic stem cells (HSCs) can alleviate liver fibrosis. Ten sex-mismatched donor-recipient pairs who received co-transplantation of HSCs with mesenchymal stem cells were included in our study. Liver biopsy was performed before transplantation. Two other liver biopsies were performed between 2 and 5 years after transplantation...
November 17, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29150779/perioperative-transesophageal-echocardiography-for-non-cardiac-surgery
#4
REVIEW
Ashraf Fayad, Sasha K Shillcutt
PURPOSE: The use of transesophageal echocardiography (TEE) has evolved to include patients undergoing high-risk non-cardiac procedures and patients with significant cardiac disease undergoing non-cardiac surgery. Implementation of basic TEE education in training programs has increased across a broad spectrum of procedures in the perioperative arena. This paper describes the use of perioperative TEE in non-cardiac surgery and provides an overview of the basic TEE examination. PRINCIPAL FINDINGS: Perioperative TEE is used to monitor hemodynamic parameters in non-cardiac procedures where there is a high risk of hemodynamic instability...
November 17, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29150644/therapeutic-effects-of-hepatocyte-growth-factor-overexpressing-dental-pulp-stem-cells-on-liver-cirrhosis-in-a-rat-model
#5
Xiao-Fang Cao, Shi-Zhu Jin, Liang Sun, Yuan-Bo Zhan, Feng Lin, Ying Li, Ying-Lian Zhou, Xiu-Mei Wang, Li Gao, Bin Zhang
Cirrhosis is the terminal stage of hepatic diseases and is prone to develop into hepatocyte carcinoma. Increasing evidence suggests that the transplantation of dental pulp stem cells (DPSCs) may promote recovery from cirrhosis, but the key regulatory mechanisms involved remain to be determined. In this study, we overexpressed human hepatocyte growth factor (hHGF) in primary rat DPSCs and evaluated the effects of HGF overexpression on the biological behaviors and therapeutic efficacy of grafted DPSCs in cirrhosis...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150112/passenger-lymphocyte-syndrome-in-liver-transplantation
#6
Denise M Brunetta, Lilian M de Albuquerque, Andressa H de Morais Batista, Lhais Helenne O Santos, Dirk Schreen, Clébia A de Lima, Denissa F G Mesquita, Luciana Maria de B Carlos, José Huygens P Garcia
No abstract text is available yet for this article.
October 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/29149976/clinical-challenges-of-tacrolimus-for-maintenance-immunosuppression-post-lung-transplantation
#7
S Ivulich, M Dooley, C Kirkpatrick, G Snell
Lung transplantation (LTx) is a successful treatment option for end-stage lung disease, and immunosuppressant regimens, utilized to prevent rejection of the transplanted graft, are paramount to maintaining long-term graft survival. Immunosuppression can be classified as induction, maintenance, and antirejection therapy. This article focuses on maintenance immunosuppression that includes a combination of a calcineurin inhibitor (CNI), cell cycle inhibitor, and corticosteroid. CNIs remain the cornerstone of immunosuppression following LTx, and tacrolimus is now the preferred CNI, based on a better adverse effect profile and some limited evidence for enhanced efficacy...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149975/clinical-outcomes-of-living-liver-transplantation-according-to-the-presence-of-sarcopenia-as-defined-by-skeletal-muscle-mass-hand-grip-and-gait-speed
#8
N Harimoto, T Yoshizumi, T Izumi, T Motomura, N Harada, S Itoh, T Ikegami, H Uchiyama, Y Soejima, A Nishie, T Kamishima, R Kusaba, K Shirabe, Y Maehara
BACKGROUND: Sarcopenia is an independent predictor of death after living-donor liver transplantation (LDLT). However, the ability of the Asian Working Group for Sarcopenia criteria for sarcopenia (defined as reduced skeletal muscle mass plus low muscle strength) to predict surgical outcomes in patients who have undergone LDLT has not been determined. METHODS: This study prospectively enrolled 366 patients who underwent LDLT at Kyushu University Hospital. Skeletal muscle area (determined by computed tomography), hand-grip strength, and gait speed were measured in 102 patients before LDLT...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149974/liver-transplantation-with-old-grafts-a-ten-year-experience
#9
S Roullet, M Defaye, A Quinart, J-P Adam, L Chiche, C Laurent, M Neau-Cransac
BACKGROUND: The persistent scarcity of donors has prompted liver transplantation teams to find solutions for increasing graft availability. We report our experience of liver transplantations performed with grafts from older donors, specifically over 70 and 80 years old. PATIENTS AND METHODS: We analyzed our prospectively maintained single-center database from January 1, 2005, to December 31, 2014, with 380 liver transplantations performed in 354 patients. Six groups were composed according to donor age: <40 (n = 84), 40 to 49 (n = 67), from 50 to 59 (n = 62), from 60 to 69 (n = 76), from 70 to 79 (n = 64), and ≥80 years (n = 27)...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149973/hepatitis-c-virus-recurrence-occurs-earlier-in-patients-receiving-donation-after-circulatory-death-liver-transplant-grafts-compared-with-those-receiving-donation-after-brainstem-death-grafts
#10
S A Townsend, M A Monga, P Nightingale, D Mutimer, A M Elsharkawy, A Holt
INTRODUCTION: Hepatitis C virus (HCV)-related cirrhosis remains the commonest indication for liver transplantation worldwide, yet few studies have investigated the impact of donation after circulatory death (DCD) graft use on HCV recurrence and patient outcomes. DCD grafts have augmented the limited donor organ pool and reduced wait-list mortality, although concerns regarding graft longevity and patient outcome persist. METHODS: This was a single-center study of all HCV + adults who underwent DCD liver transplantation between 2004 and 2014...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149972/right-extended-split-liver-transplantation-compared-with-whole-liver-transplantation-lessons-learned-at-a-single-center-in-latin-america-results-from-a-match-case-control-study
#11
S E Gambaro, P Romero, N Pedraza, L Moulin, S Yantorno, D Ramisch, C Rumbo, P Barros-Schelotto, V Descalzi, G E Gondolesi
BACKGROUND: Despite the progressively increasing gap between patients waiting for liver transplant under the Model for End-stage Liver Disease MELD system and the availability of deceased donor organs, the use of right extended split liver grafts (RESLG) has not been accepted by all centers. In this study, we compared the results obtained using RESLG vs a group of matched whole liver graft (WLG) recipients at a single center in Latin America. METHODS: A single-center retrospective review performed between August 2009 and December 2015...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149971/fibrinolysis-in-living-donor-liver-transplantation-recipients-evaluated-using-thromboelastometry-impact-on-mortality
#12
T Shimauchi, K Yamaura, M Higashi, K Abe, T Yoshizumi, S Hoka
BACKGROUND: Inadequate hemostasis during living donor liver transplantation (LDLT) is mainly due to coagulopathy but may also include fibrinolysis. The purpose of this study was to determine the incidence of fibrinolysis and assess its relevance to mortality in LDLT. METHODS: The incidence and prognosis of fibrinolysis were retrospectively studied in 76 patients who underwent LDLT between April 2010 and February 2013. Fibrinolysis was evaluated and defined by maximum lysis (ML) >15% within a 60-minute run time using thromboelastometry (ROTEM)...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149970/thromboelastography-as-a-predictor-of-outcomes-following-liver-transplantation
#13
C L Trautman, W C Palmer, C B Taner, J M Canabal, T Getz, A Goldman, M G Heckman, N N Diehl, D D Lee, F F Stancampiano
BACKGROUND: Thromboelastography (TEG) has been used perioperatively during liver transplantation (LT) to provide a real-time global hemostasis assessment for targeted blood product replacement. We aimed to analyze the relationship between post-LT TEG results and outcomes. METHODS: We retrospectively analyzed patients undergoing LT from November 2008 to December 2014 at Mayo Clinic Florida. All 441 single-organ 1st-time LT patients aged ≥18 years requiring post-LT intensive care unit management were included...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149969/indicators-of-complex-care-during-the-consultation-liaison-psychiatry-activity-at-the-transplant-center-of-the-policlinico-hospital-modena
#14
G Mattei, A Laghi, S Balduzzi, M Moscara, C Piemonte, C Reggianini, M Rigatelli, S Ferrari, L Pingani, G M Galeazzi
OBJECTIVE: The objective of this study was to identify possible biopsychosocial predictors of organizational complexity in patients referred to the consultant psychiatrist for assessment before liver transplantation. METHODS: This was a case-control study. All psychiatric consultations performed before and after liver transplantation from January 1, 2008 to December 31, 2013 were included. Complexity was operationalized as "undergoing two or more psychiatric consultations"...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149964/chikungunya-infection-in-solid-organ-transplant-recipients
#15
E S Girão, B G Rodrigues Dos Santos, E S do Amaral, P E G Costa, K B Pereira, A H de Araujo Filho, E B Hyppolito, M U Mota, L C B F Marques, C M Costa de Oliveira, S L da Silva, J H P Garcia, P F C B C Fernandes
BACKGROUND: Chikungunya virus (CHIKV) is an emerging mosquito-borne disease that causes acute febrile polyarthralgia and arthritis. CHIKV has spread rapidly to the Americas and, in Brazil, autochthonous cases are increasingly been reported. Solid organ transplant (SOT) recipients who travel to or live in CHIKV endemic areas are under high risk of acquiring the disease. Few data exist regarding the clinical characteristics of CHIKV infections in this population. We report the first case series of CHIKV infection in SOT recipients...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149510/transferrin-as-a-predictor-of-survival-in-cirrhosis
#16
André Viveiros, Armin Finkenstedt, Benedikt Schaefer, Mattias Mandorfer, Bernhard Scheiner, Konrad Lehner, Moritz Tobiasch, Thomas Reiberger, Herbert Tilg, Michael Edlinger, Heinz Zoller
BACKGROUND AND AIMS: Patients with cirrhosis frequently present with high serum ferritin and low transferrin concentrations, reflecting impaired liver function and inflammation. Recent studies have shown that transferrin and its saturation with iron are MELD-independent predictors of mortality in patients with acute on chronic liver failure or decompensated cirrhosis. The aim of this study was to evaluate the prognostic utility of serum iron parameters in relation to markers of liver function and immune activation...
November 17, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29149464/novel-intra-operative-management-in-the-meld-na-era-continuous-veno-venous-hemofiltration-for-severe-hyponatremia-in-liver-transplantation
#17
Shunji Nagai, Dilip Moonka, Anita Patel
No abstract text is available yet for this article.
November 17, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29149103/human-hepatocyte-transplantation-for-liver-disease-current-status-and-future-perspectives
#18
REVIEW
Valeria Iansante, Ragai R Mitry, Céline Filippi, Emer Fitzpatrick, Anil Dhawan
Liver transplantation is the accepted treatment for patients with acute liver failure and liver-based metabolic disorders. However, donor organ shortage and lifelong need for immunosuppression are the main limitations to liver transplantation. In addition, loss of the native liver as target organ for future gene therapy for metabolic disorders limits the futuristic treatment options, resulting in the need for alternative therapeutic strategies. A potential alternative to liver transplantation is allogeneic hepatocyte transplantation...
November 14, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29148096/performance-of-the-dimension-tac-assay-and-comparison-of-multiple-platforms-for-the-measurement-of-tacrolimus
#19
Eun-Jung Cho, Dae-Hyun Ko, Woochang Lee, Sail Chun, Hae-Kyung Lee, Won-Ki Min
BACKGROUND: Therapeutic monitoring of tacrolimus is essential for reducing organ rejection and adverse effects. The measurement of tacrolimus in whole blood is taken by many automated platforms. We evaluated the analytical performance of the Dimension TAC assay, which is an upgraded reagent from the previous Dimension TACR assay. METHODS: The evaluations involved determination of precision, linearity, detection capability, and reagent lot-to-lot variability between three lot numbers...
November 17, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29147139/insights-into-the-management-of-wilson-s-disease
#20
REVIEW
Mohmadshakil Kathawala, Gideon M Hirschfield
Wilson's disease is a rare, inherited autosomal recessive disease of copper metabolism, in which the causative gene, ATP7B, results in absent or reduced function of the ATP7B transporter important for biliary excretion of copper and incorporation of copper into caeruloplasmin. Affected patients accumulate excessive copper within the liver, brain and other tissues. A disease mainly of children, adolescents and young adults; clinical features vary from the asymptomatic state to chronic liver disease, acute liver failure, and neuropsychiatric manifestations...
November 2017: Therapeutic Advances in Gastroenterology
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