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Christine Aroney, Samantha Fraser-Bell, Ecosse L Lamoureux, Mark C Gillies, Lyndell L Lim, Eva K Fenwick
Purpose: To determine the patient-centered effectiveness of treatment with the slow-release dexamethasone intravitreal implant (DEX implant) and intravitreal bevacizumab using the Impact of Vision Impairment Questionnaire (IVI), a vision-related quality of life (VRQoL) measure, in patients with visual impairment secondary to center-involving diabetic macular edema (DME). Methods: Patients with DME were enrolled in a phase 2, prospective, multicenter, randomized, single-masked clinical trial and received either DEX implant 4 monthly or bevacizumab monthly, both pro re nata...
October 1, 2016: Investigative Ophthalmology & Visual Science
Emily Dalton, Natasha A Lannin, Kate Laver, Leo Ross, Stephen Ashford, Annie McCluskey, Anne Cusick
PURPOSE: The Disabilities of Arm, Shoulder and Hand (DASH) questionnaire is a patient reported outcome measure for evaluating upper limb function in people with musculoskeletal conditions. While the DASH has good psychometric properties when used with people with musculoskeletal conditions, it has not been tested with adults after stroke. METHODS: Data for n = 61 adults following stroke (aged 32-93 years, 44% male) were analyzed to test validity and reliability of the DASH for use with a stroke population...
October 21, 2016: Disability and Rehabilitation
David Singer, Jacqueline E McLaughlin, Wendy C Cox
Objective. To assess the multiple mini-interview (MMI) as an admission tool for a satellite campus. Methods. In 2013, the MMI was implemented as part of a new admissions model at the UNC Eshelman School of Pharmacy. From fall 2013 to spring 2015, 73 candidates were interviewed by 15 raters on the satellite campus in Asheville, North Carolina. A many-facet Rasch measurement (MFRM) with three facets was used to determine the variance in candidate ratings attributable to rater severity, candidate ability, and station difficulty...
September 25, 2016: American Journal of Pharmaceutical Education
Kalliopi Vrotsou, Ricardo Cuéllar, Félix Silió, Miguel Ángel Rodriguez, Daniel Garay, Gorka Busto, Ziortza Trancho, Antonio Escobar
BACKGROUND: The aim of the current study was to validate the self-report section of the American Shoulder and Elbow Surgeons questionnaire (ASES-p) into Spanish. METHODS: Shoulder pathology patients were recruited and followed up to 6 months post treatment. The ASES-p, Constant, SF-36 and Barthel scales were filled-in pre and post treatment. Reliability was tested with Cronbach's alpha, convergent validity with Spearman's correlations coefficients. Confirmatory factor analysis (CFA) and the Rasch model were implemented for assessing structural validity and unidimensionality of the scale...
October 18, 2016: Health and Quality of Life Outcomes
Ickpyo Hong, Heather S Bonilha
The aim of this study was to provide a systematic review of psychometric studies of upper extremity (UE) outcome measures validated by Rasch analysis and assess the extent to which their measurement areas cover the domains of the International Classification of Functioning, Disability and Health model. A literature search from 1966 to 2014 was performed using PubMed, CINAHL, Scopus, PsycINFO, Ovid/MEDLINE, ERIC, and Cochrane library. Fourteen keywords indicating 'upper extremity', 'psychometric properties', and 'outcome measures' were used...
October 14, 2016: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
Skye P Barbic, Stefan J Cano
This commentary argues the importance of robust, meaningful assessment of clinical and functional outcomes in psychiatry. Outcome assessments should be fit for the purpose of measuring relevant concepts of interest in specific clinical settings. As well, the measurement model selected to develop and test assessments can be critical for guiding care. Three types of measurement models are presented: classical test theory, item response theory, and Rasch measurement theory. To optimise current diagnostic and treatment practices in psychiatry, careful consideration of these models is warranted...
October 2016: BJPsych Bulletin
Mike Horton, Amanda E Perry
Aims and method To explore the modern psychometric properties of the Patient Health Questionnaire (PHQ-9), we used the Rasch analysis in a sample of 767 primary care patients with depression. Results The analysis highlighted dependency issues between items 1 and 2 ('Little interest or pleasure in doing things' and 'Feeling down, depressed, or hopeless'), and items 3 and 4 ('Trouble falling or staying asleep, or sleeping too much' and 'Feeling tired or having little energy'). Items 1 and 2 displayed an over-discrimination, suggesting their potential redundancy within the complete item set...
October 2016: BJPsych Bulletin
Rachel L Z Goh, Eva Fenwick, Simon E Skalicky
PURPOSE: As health budgets tighten globally, evaluating the cost-effectiveness of glaucoma services is vital; however, there is a lack of validated instruments that measure utility specific to glaucoma patients. We thus evaluated the validity of the Visual Function Questionnaire-Utility Index (VFQ-UI) as a measure of vision-related function and preference-based status in glaucoma. PATIENTS AND METHODS: Cross-sectional study of 141 volunteer patients over 40 years of age with moderate (n=64) or severe (n=36) glaucoma, and 41 controls...
October 2016: Journal of Glaucoma
Birgit Kleim, Julia Wysokowsky, Nuria Schmid, Erich Seifritz, Björn Rasch
STUDY OBJECTIVE: To investigate sleep's effect in the immediate aftermath of experiencing an analog trauma in the laboratory on reducing intrusive emotional memory formation. METHODS: Sixty-five healthy women were exposed to an experimental laboratory trauma. They viewed a neutral and a trauma film in the laboratory and were randomly allocated to either a group that slept following film viewing or a group that remained awake. Sleep was recorded with electroencephalogram in a subgroup of participants in the sleep group...
October 10, 2016: Sleep
Julius T Kamwesiga, Lena von Koch, Anders Kottorp, Susanne Guidetti
BACKGROUND: Knowledge is scarce about the impact of stroke in Uganda, and culturally adapted, psychometrically tested patient-reported outcome measures are lacking. The Stroke Impact Scale 3.0 is recommended, but it has not been culturally adapted and validated in Uganda. OBJECTIVE: To culturally adapt and determine the psychometric properties of the Stroke Impact Scale 3.0 in the Ugandan context on a small scale. METHOD: The Stroke Impact Scale 3...
2016: SAGE Open Medicine
Alice Rodrigues Willhelm, Paula Madeira Fortes, Fernanda Rasch Czermainski, Aline Schwalm Andrade Rates, Rosa Maria Martins de Almeida
Introduction: The aim of neuropsychological assessment is to understand the multifaceted relationship between behavior, cognition and brain organization. The main objective of this study was to conduct a systematic review of the literature on impulsivity and inhibitory control in healthy adolescents and preadolescents. Method: Three researchers conducted a systematic review on November 25, 2014. The first step was to conduct searches on the Web of Knowledge and PubMed databases for articles in English using the following keywords: child; adolescents; impulsivity; inhibition; inhibitory control; and neuropsychology...
July 2016: Trends in Psychiatry and Psychotherapy
Jyoti Khadka, Jinhai Huang, Haisi Chen, Chengwei Chen, Rongrong Gao, Fangjun Bao, Sifang Zhang, Qinmei Wang, Konrad Pesudovs
PURPOSE: To assess cataract surgery outcome using the Rasch scaled Chinese version of the Catquest short-form. METHODS: The Chinese translated and culturally adapted version of the Catquest-9SF was interviewer-administered to patients, pre and post cataract surgery. Rasch analysis was performed on the baseline data to revise the Catquest. For the surgical outcome assessment, we stacked pre- and post-surgical Catquest data to demonstrate improvement in visual function scores and responsiveness of the instrument to cataract surgery...
2016: PloS One
Mia Forslin, Anders Kottorp, Marie Kierkegaard, Sverker Johansson
OBJECTIVES: To translate and culturally adapt the Acceptance of Chronic Health Conditions (ACHC) Scale for people with multiple sclerosis into Swedish, and to analyse the psychometric properties of the Swedish version. SUBJECTS: Ten people with multiple sclerosis participated in translation and cultural adaptation of the ACHC Scale; 148 people with multiple sclerosis were included in evaluation of the psychometric properties of the scale. METHODS: Translation and cultural adaptation were carried out through translation and back-translation, by expert committee evaluation and pre-test with cognitive interviews in people with multiple sclerosis...
September 28, 2016: Journal of Rehabilitation Medicine
Judith Zimmermann, Mary K Musyoki, Georg Cadisch, Frank Rasche
We studied the effects of Fusarium oxysporum f.sp. strigae (Fos), a soil-borne biocontrol agent (BCA) against Striga hermonthica, on total fungal and arbuscular mycorrhizal fungal (AMF) taxa in rhizospheres of maize in both clayey and sandy soil. Effects of Fos-BCA 'Foxy-2' were evaluated against (1) S. hermonthica presence, and (2) organic fertilization with Tithonia diversifolia residues at 14, 28 and 42 d after 'Foxy-2' inoculation, via DNA-based quantitative PCR and TRFLP fingerprinting. In both soils, 'Foxy-2' occasionally promoted total fungal abundance, while the community composition was mainly altered by T...
October 2016: Fungal Ecology
Laura A Wyatt, Bryan J Moreton, Paul I Mapp, Deborah Wilson, Roger Hill, Eamonn Ferguson, Brigitte E Scammell, David A Walsh
OBJECTIVE: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated measures of OA histopathological features. DESIGN: Medial tibial plateaux and synovium were from 343 post-mortem (PM) and 143 OA arthroplasty donations. A `chondropathy/osteophyte' group (n=217) was classified as PM cases with osteophytes or macroscopic medial tibiofemoral chondropathy lesions ≥ grade 3 to represent pre-surgical (early) OA...
October 6, 2016: Osteoarthritis and Cartilage
Jens G Klinzing, Björn Rasch, Jan Born, Susanne Diekelmann
Sleep is known to support the consolidation of newly encoded and initially labile memories. Once consolidated, remote memories can return to a labile state upon reactivation and need to become reconsolidated in order to persist. Here we asked whether sleep also benefits the reconsolidation of remote memories after their reactivation and how reconsolidation during sleep compares to sleep-dependent consolidation processes. In three groups, participants were trained on a visuo-spatial learning task in the presence of a contextual odor...
October 6, 2016: Neurobiology of Learning and Memory
Anne Moessner, James F Malec, Scott Beveridge, Cara Camiolo Reddy, Tracy Huffman, Julia Marton, Audrey J Schmerzler
PRIMARY OBJECTIVE: To develop and provide initial validation of a measure for accurately determining the need for Constant Visual Observation (CVO) in patients with traumatic brain injury (TBI) admitted to inpatient rehabilitation. RESEARCH DESIGN: Rating scale development and evaluation through Rasch analysis and assessment of concurrent validity. METHODS AND PROCEDURES: One hundred and thirty-four individuals with moderate-severe TBI were studied in seven inpatient brain rehabilitation units associated with the National Institute for Disability, Independent Living and Rehabilitation Research (NIDILRR) TBI Model System...
August 11, 2016: Brain Injury: [BI]
Michael Pt Lunn, Eduardo Nobile-Orazio
BACKGROUND: Serum monoclonal anti-myelin-associated glycoprotein (anti-MAG) antibodies may be pathogenic in some people with immunoglobulin M (IgM) paraprotein and demyelinating neuropathy. Immunotherapies aimed at reducing the level of these antibodies might be expected to be beneficial. This is an update of a review first published in 2003 and previously updated in 2006 and 2012. OBJECTIVES: To assess the effects of immunotherapy for IgM anti-MAG paraprotein-associated demyelinating peripheral neuropathy...
October 4, 2016: Cochrane Database of Systematic Reviews
Nancy Lee, Carolyn E Rydyznski, Matthew S Rasch, Dennis S Trinh, A John MacLennan
Exogenous ciliary neurotrophic factor (CNTF) administration promotes the survival of motor neurons in a wide range of models. It also increases the expression of the critical neurotransmitter enzyme, choline acetyltransferase (ChAT), by in vitro motor neurons, likely independent of its effects on their survival. We have used the adult mouse facial nerve crush model and adult onset conditional disruption of the CNTF receptor α (CNTFRα) gene to directly examine the in vivo roles played by endogenous CNTF receptors in adult motor neuron survival and ChAT maintenance, independent of developmental functions...
September 26, 2016: Journal of Comparative Neurology
Carolin Sellmann, Achim Doerner, Christine Knuehl, Nicolas Rasche, Vanita Sood, Simon Krah, Laura Rhiel, Annika Messemer, John Wesolowski, Mark Schuette, Stefan Becker, Lars Toleikis, Harald Kolmar, Bjoern Hock
Bispecific antibodies (bsAbs) and antibody-drug conjugates (ADCs), have already demonstrated benefits for the treatment of cancer in several clinical studies, showing improved drug selectivity and efficacy. In particular, simultaneous targeting of prominent cancer antigens, such as EGF receptor (EGFR) and c-MET, by bsAbs has raised increasing interest for potentially circumventing receptor crosstalk and c-MET mediated acquired resistance during anti-EGFR monotherapy. In this study, we combined the selectivity of EGFR x c-MET bsAbs with the potency of cytotoxic agents via bispecific antibody-toxin conjugation...
September 30, 2016: Journal of Biological Chemistry
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