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https://www.readbyqxmd.com/read/28432222/low-expression-of-hexokinase-2-is-associated-with-false-negative-fdg-positron-emission-tomography-in-multiple-myeloma
#1
Leo Rasche, Edgardo Angtuaco, James E McDonald, Amy Buros, Caleb Stein, Charlotte Pawlyn, Sharmilan Thanendrarajan, Carolina Schinke, Rohan Samant, Shmuel Yaccoby, Brian Walker, Joshua Epstein, Maurizio Zangari, Frits van Rhee, Tobias Meissner, Hartmut Goldschmidt, Kari Hemminki, Richard Houlston, Bart Barlogie, Faith E Davies, Gareth J Morgan, Niels Weinhold
18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) and diffusion weighted magnetic resonance imaging with background signal suppression (DWIBS) are two powerful functional imaging modalities in the evaluation of the malignant plasma cell (PC) disease multiple myeloma (MM). Preliminary observations have suggested that MM patients with extensive disease according to DWIBS may be reported as being disease-free on FDG-PET ("PET-false-negative"). The aim of this study was to describe the proportion of PET-false-negativity in a representative set of 227 newly diagnosed MM patients with simultaneous assessment of FDG-PET and DWIBS, and to identify tumor-intrinsic features associated with this pattern...
April 21, 2017: Blood
https://www.readbyqxmd.com/read/28431262/immunologic-approaches-for-the-treatment-of-multiple-myeloma
#2
REVIEW
Leo Rasche, Niels Weinhold, Gareth J Morgan, Frits van Rhee, Faith E Davies
The FDA approval of two monoclonal antibodies in 2015has heralded a new era of targeted immunotherapies for multiple myeloma (MM). In this review we discuss the recent approaches using different immunological components to treat MM. In particular, we review current monoclonal antibody based therapies, engineered T- and NK cell products, 'off-target' immunomodulation, and strategies utilizing allogeneic cell transplantation in MM. We discuss how an immunologic approach offers promise for the treatment of this genetically heterogeneous disease, and how patients with acquired drug resistance may particularly benefit from these therapies...
April 6, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28427158/the-varied-distribution-and-impact-of-ras-codon-and-other-key-dna-alterations-across-the-translocation-cyclin-d-subgroups-in-multiple-myeloma
#3
Caleb K Stein, Charlotte Pawlyn, Shweta Chavan, Leo Rasche, Niels Weinhold, Adam Corken, Amy Buros, Pieter Sonneveld, Graham H Jackson, Ola Landgren, Tariq Mughal, Jie He, Bart Barlogie, P Leif Bergsagel, Faith E Davies, Brian A Walker, Gareth J Morgan
We examined a set of 805 cases that underwent DNA sequencing using the FoundationOne Heme (F1H) targeted sequencing panel and gene expression profiling. Known and likely variant calls from the mutational data were analyzed for significant associations with gene expression defined translocation cyclin D (TC) molecular subgroups. The spectrum of KRAS, NRAS, and BRAF codon mutations varied across subgroups with NRAS mutations at Q61 codon being common in hyperdiploid (HRD) and t(11;14) myeloma while being rare in MMSET and MAF...
February 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28425021/is-the-autism-spectrum-quotient-a-valid-measure-of-traits-associated-with-the-autism-spectrum-a-rasch-validation-in-adults-with-and-without-autism-spectrum-disorders
#4
Lars-Olov Lundqvist, Helen Lindner
The Autism-Spectrum Quotient (AQ) is among the most widely used scales assessing autistic traits in the general population. However, some aspects of the AQ are questionable. To test its scale properties, the AQ was translated into Swedish, and data were collected from 349 adults, 130 with autism spectrum disorder (ASD) and 219 without ASD, and analysed with Rasch. Several scale properties of the AQ were satisfactory but it did not meet the criterion of a unidimensional measure of autistic traits. The Rasch analysis showed that the 50-item AQ could be reduced to a 12-item subset with little loss of explanatory power, with the potential to efficiently measure the degree to which adults with and without ASD show autistic traits...
April 19, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28422409/validation-of-the-japanese-version-of-the-fremantle-back-awareness-questionnaire-in-patients-with-low-back-pain
#5
Tomokiko Nishigami, Akira Mibu, Katsuyoshi Tanaka, Yuh Yamashita, Michele Eisemann Shimizu, Bennedict Wand, Mark J Catley, Tasha R Stanton, G Lorimer Moseley
BACKGROUND: There is a growing interest in the role of disturbed body perception in people with persistent pain problems such as chronic low back pain (CLBP). A questionnaire, the Fremantle Back Awareness Questionnaire (FreBAQ), was recently developed as a simple and quick way of assessing disturbed perceptual awareness of the back in people with CLBP and appears to have acceptable psychometric properties. The aim of the present study was to develop a Japanese version of the FreBAQ (FreBAQ-J) and evaluate its psychometric properties in a sample of Japanese people with low back pain (LBP)...
April 18, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28419819/path-to-illness-intrusiveness-what-symptoms-impact-the-life-of-people-living-with-multiple-sclerosis
#6
Vanessa Bouchard, Pierre Duquette, Nancy E Mayo
OBJECTIVE: To determine the direct and indirect effects of physical, emotional, and cognitive impairments on illness intrusiveness in people with MS. DESIGN: Secondary analysis of a cross sectional data set collected in 2008 to identify gender differences in people living with MS. SETTING: Three MS clinics in the Greater Montréal region, Canada. PARTICIPANTS: A random sample of 135 women and 48 men diagnosed with Multiple Sclerosis after 1995 recruited and evaluated in 2008...
April 15, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28419641/neural-correlates-of-experimental-trauma-memory-retrieval
#7
Geraldine A Gvozdanovic, Philipp Stämpfli, Erich Seifritz, Björn Rasch
OBJECTIVES: Traumatic memories such as intrusions and flashbacks play a major role in the development and maintenance of post-traumatic stress disorder (PTSD). A thorough understanding of the neural mechanisms underlying traumatic memories is indispensable for precise diagnosis, for personalized treatment and prevention. In particular, the identification of early neural predictor variables for intrusion development shortly after trauma exposure requires detailed investigation. EXPERIMENTAL DESIGN: Here, we examined the neural correlates of early experimental trauma memory retrieval in a traumatic film paradigm in 42 young healthy females, using both implicit and explicit retrieval tasks...
April 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28412981/differences-in-the-use-of-everyday-technology-among-persons-with-mci-sci-and-older-adults-without-known-cognitive-impairment
#8
Camilla Malinowsky, Anders Kottorp, Anders Wallin, Arto Nordlund, Eva Björklund, Ilse Melin, Anette Pernevik, Lena Rosenberg, Louise Nygård
BACKGROUND: To use valid subjective reports sensible to cognitive decline is vital to identify very early signs of dementia development. Use of everyday technology (ET) has been shown to be sensitive to differentiate adults with mild cognitive impairment (MCI) from controls, but the group with subjective cognitive impairment (SCI) has not yet been examined. This study aims to investigate and compare self-perceived ability in ET use and number of ETs reported as actually used in a sample of older adults with SCI, MCI, and older adults with no known cognitive impairment, i...
April 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28407666/influence-of-erythropoiesis-stimulating-agents-on-hba1c-and-fructosamine-in-patients-with-haemodialysis
#9
Franz Maximilian Rasche, Thomas Ebert, Julia Beckmann, Volker Busch, Filip Barinka, Wilma Gertrud Rasche, Tom H Lindner, Jochen G Schneider, Stephan Schiekofer
HbA1c is the most accepted laboratory parameter for the long term observation of glucose control. There is still much of a debate about the use of HbA1c as a metabolic indicator in diabetic patients (DM) on haemodialysis (HD) and erythropoiesis-stimulating agent (ESA) therapy because of the altered erythrocyte turn over in patients with chronic kidney disease and haemodialysis (CKD5D). In 102 CKD5 patients with and without diabetes mellitus, we examined the dose dependent variability in HbA1c and fructosamine levels under haemodialysis and treated with epoetin α (n=48) and a new generation agent with continuous stimulation of methoxy polyethylene glycol epoetin beta (C...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28400376/therapy-reduction-in-patients-with-down-syndrome-myeloid-leukemia-the-international-ml-ds-2006-trial
#10
Madita Uffmann, Mareike Rasche, Martin Zimmermann, Christine von Neuhoff, Ursula Creutzig, Michael Dworzak, Lenie Scheffers, Henrik Hasle, C Michel Zwaan, Dirk Reinhardt, Jan-Henning Klusmann
Children with Down syndrome and myeloid leukemia (ML-DS) have a superior outcome compared to non-DS patients, but suffer from higher constitutional susceptibility to cytotoxic drugs. We analyzed the outcome of 170 pediatric patients with ML-DS enrolled in the prospective, multi-center, open-label, non-randomized ML-DS 2006 trial, by the NOPHO, DCOG and AML-BFM study groups. In comparison to the historical control arm (reduced intensity protocol for ML-DS patients from the AML-BFM 98 trial) treatment intensity was reduced by lowering the cumulative dose of etoposide (950 mg/m(2) to 450 mg/m(2)) and intrathecal CNS-prophylaxis while omitting maintenance therapy...
April 11, 2017: Blood
https://www.readbyqxmd.com/read/28395696/reliability-and-validity-of-the-self-efficacy-for-exercise-in-epilepsy-and-the-outcome-expectations-for-exercise-in-epilepsy-scales
#11
Irene Dustin, Barbara Resnick, Elizabeth Galik, N Jennifer Klinedinst, Kathleen Michael, Edythe Wiggs
PURPOSE: The purpose of this study was to test the psychometric properties of the revised Self-Efficacy for Exercise With Epilepsy (SEE-E) and Outcome Expectations for Exercise with Epilepsy (OEE-E) when used with people with epilepsy. METHODS: The SEE-E and OEE-E were given in face-to-face interviews to 26 persons with epilepsy in an epilepsy clinic. RESULTS: There was some evidence of validity based on Rasch analysis INFIT and OUTFIT statistics...
April 1, 2017: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/28392695/the-maugeri-stress-index-reduced-form-a-questionnaire-for-job-stress-assessment
#12
Davide Massidda, Ines Giorgi, Giulio Vidotto, Salvatore Tringali, Marcello Imbriani, Paola Baiardi, Giorgio Bertolotti
INTRODUCTION AND OBJECTIVES: A multidimensional self-report questionnaire to evaluate job-related stress factors is presented. The questionnaire, called Maugeri Stress Index - reduced form (MASI-R), aims to assess the impact of job strain on a team or on a single worker by considering four domains: wellness, resilience, perception of social support, and reactions to stressful situations. MATERIAL AND METHODS: The reliability of a first longer version (47 items) of the questionnaire was evaluated by an internal consistency analysis and a confirmatory factor analysis...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28388899/validation-of-the-dutch-version-of-the-swallowing-quality-of-life-questionnaire-dswal-qol-and-the-adjusted-dswal-qol-adswal-qol-using-item-analysis-with-the-rasch-model-a-pilot-study
#13
Ingeborg S Simpelaere, Gwen Van Nuffelen, Marc De Bodt, Jan Vanderwegen, Tina Hansen
BACKGROUND: The Swallowing Quality-of-Life Questionnaire (SWAL-QoL) is considered the gold standard for assessing health-related QoL in oropharyngeal dysphagia. The Dutch translation (DSWAL-QoL) and its adjusted version (aDSWAL-QoL) have been validated using classical test theory (CTT). However, these scales have not been tested against the Rasch measurement model, which is required to establish the structural validity and objectivity of the total scale and subscale scores. Thus, the purpose of this study was to examine the psychometric properties of these scales using item analysis according to the Rasch model...
April 7, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28388676/epstein-barr-virus-antibodies-in-serum-and-dna-load-in-saliva-are-not-associated-with-radiological-or-clinical-disease-activity-in-patients-with-early-multiple-sclerosis
#14
René M Gieß, Catherina Pfuhl, Janina R Behrens, Ludwig Rasche, Erik Freitag, Nima Khalighy, Carolin Otto, Jens Wuerfel, Alexander U Brandt, Jörg Hofmann, Bettina Eberspächer, Judith Bellmann-Strobl, Friedemann Paul, Klemens Ruprecht
OBJECTIVE: To investigate the association of Epstein-Barr virus (EBV) nuclear antigen-1 (EBNA-1) and viral capsid antigen (VCA) immunoglobulin (Ig)G antibodies in serum as well as EBV DNA load in saliva with radiological and clinical disease activity in patients with clinically isolated syndrome (CIS) and early relapsing-remitting MS (RRMS). METHODS: EBNA-1 and VCA immunoglobulin (Ig)G antibodies were determined in serum of 100 patients with CIS/early RRMS and 60 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28385092/everyday-technology-use-among-older-adults-in-sweden-and-portugal
#15
Ann-Helen Patomella, Anders Kottorp, Manuela Ferreira, Lena Rosenberg, Brittmari Uppgard, Louise Nygård
BACKGROUND: Technology use is relevant for engaging in everyday occupations and aging in place and difficulties might limit participation. AIM: The aim of the present study was two-fold: to investigate the internal scale validity of the Everyday Technology Use Questionnaire (ETUQ) in a matched Portuguese and a Swedish sample of older adults without known cognitive impairments and to compare everyday technology use (i.e., the relevance of Everyday Technology (ET) and perceived difficulty of using ET)...
April 7, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28382503/cost-effectiveness-of-different-strategies-to-prevent-breast-and-ovarian-cancer-in-german-women-with-a-brca-1-or-2-mutation
#16
Dirk Müller, Marion Danner, Kerstin Rhiem, Björn Stollenwerk, Christoph Engel, Linda Rasche, Lisa Borsi, Rita Schmutzler, Stephanie Stock
BACKGROUND: Women with a BRCA1 or BRCA2 mutation are at increased risk of developing breast and/or ovarian cancer. This economic modeling study evaluated different preventive interventions for 30-year-old women with a confirmed BRCA (1 or 2) mutation. METHODS: A Markov model was developed to estimate the costs and benefits [i.e., quality-adjusted life years (QALYs), and life years gained (LYG)] associated with prophylactic bilateral mastectomy (BM), prophylactic bilateral salpingo-oophorectomy (BSO), BM plus BSO, BM plus BSO at age 40, and intensified surveillance...
April 5, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28382403/meaningful-patient-engagement-in-inflammatory-arthritis-development-of-the-patient-motivation-questionnaire
#17
Y El Miedany, Maha El Gaafary, Sally Youssef, Nadia El Aroussy
The objective of this study is to develop a questionnaire for evaluating the patient's "motivation" and assess the psychometric properties of that measure in patients with chronic inflammatory arthritis. Using Rasch analysis and questions item pool, content analysis, and semi-structured group discussion, the questionnaire was developed including 10-item scale (0-10 on VAS scale). Construct validity was assessed by correlating the questionnaire score to parameters of disease activity (DAS-28, ASDAS, and DAPSA scores), functional disability, quality of life, patient self-helplessness measure, as well as the patients' compliance to therapy...
April 5, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28381393/who-is-still-playing-pok%C3%A3-mon-go-a-web-based-survey
#18
Peter Rasche, Anna Schlomann, Alexander Mertens
BACKGROUND: Poor physical activity is one of the major health care problems in Western civilizations. Various digital gadgets aiming to increase physical activity, such as activity trackers or fitness apps, have been introduced over recent years. The newest products are serious games that incorporate real-life physical activity into their game concept. Recent studies have shown that such games increase the physical activity of their users over the short term. OBJECTIVE: In this study, we investigated the motivational effects of the digital game "Pokémon Go" leading to continued use or abandonment of the game...
April 5, 2017: JMIR Serious Games
https://www.readbyqxmd.com/read/28379415/adaptation-to-european-spanish-and-psychometric-properties-of-the-patient-activation-measure-13-in-patients-with-chronic-diseases
#19
Cibeles Moreno-Chico, Luis González-de Paz, Cristina Monforte-Royo, Emilia Arrighi, M Dolores Navarro-Rubio, Alberto Gallart Fernández-Puebla
Background: . The 13-item Patient Activation Measure (PAM-13) is an instrument that assesses people's knowledge, skills and confidence for self-management of their health and health care. Scores on the PAM-13 have been shown to predict adherence to health behaviours, health-related outcomes and health care costs. Objectives: . To develop a European Spanish adaptation of the original PAM-13 and to examine its psychometric properties in a sample of chronic patients...
March 31, 2017: Family Practice
https://www.readbyqxmd.com/read/28378239/usefulness-of-1-3-beta-d-glucan-detection-in-non-hiv-immunocompromised-mechanical-ventilated-critically-ill-patients-with-ards-and-suspected-pneumocystis-jirovecii-pneumonia
#20
Tobias Lahmer, Clarissa Prazeres da Costa, Jürgen Held, Sebastian Rasch, Ursula Ehmer, Roland M Schmid, Wolfgang Huber
INTRODUCTION: Pneumocystis jirovecii pneumonia (PCP) is a major cause of disease in immunocompromised individuals. Diagnosis is typically obtained by microscopy and/or PCR. For ambiguous PCR results, we evaluated the new biomarker 1,3-Beta-D-Glucan (BDG). METHODS: BDG serum levels were assessed and correlated to PCR results in immunosuppressed patients with ARDS. RESULTS: 11 (22%) out of 50 patients had suspected PCP. APACHE II (26 vs. 24; p < 0...
April 4, 2017: Mycopathologia
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