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https://www.readbyqxmd.com/read/28818056/adaptation-of-chinese-and-english-versions-of-the-ankylosing-spondylitis-quality-of-life-asqol-scale-for-use-in-singapore
#1
Ying Ying Leung, Weixian Lee, Nai Lee Lui, Matthew Rouse, Stephen P McKenna, Julian Thumboo
BACKGROUND: To cross-culturally adapt and validate the Singapore Chinese and Singapore English versions of the Ankylosing Spondylitis Quality of Life (ASQoL) scales. METHODS: Translation of the ASQoL into Singapore Chinese and English was performed by professional and lay translation panels. Field-testing for face and content validity was performed by interviewing ten Chinese speaking and ten English speaking axial spondyloarthritis (AxSpA) patients. AxSpA patients (either Chinese or English speaking) were invited to take part in validation surveys...
August 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28818036/ecccl-parallelized-gpu-implementation-of-ensemble-classifier-chains
#2
Mona Riemenschneider, Alexander Herbst, Ari Rasch, Sergei Gorlatch, Dominik Heider
BACKGROUND: Multi-label classification has recently gained great attention in diverse fields of research, e.g., in biomedical application such as protein function prediction or drug resistance testing in HIV. In this context, the concept of Classifier Chains has been shown to improve prediction accuracy, especially when applied as Ensemble Classifier Chains. However, these techniques lack computational efficiency when applied on large amounts of data, e.g., derived from next-generation sequencing experiments...
August 17, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28814779/the-beach-protein-lrba-promotes-the-localization-of-the-heterotrimeric-g-protein-golf-to-olfactory-cilia
#3
Stefan Kurtenbach, Andreas Gießl, Siv Strömberg, Jan Kremers, Jenny Atorf, Sebastian Rasche, Eva M Neuhaus, Denis Hervé, Johann Helmut Brandstätter, Esther Asan, Hanns Hatt, Manfred W Kilimann
BEACH domain proteins are involved in membrane protein traffic and human diseases, but their molecular mechanisms are not understood. The BEACH protein LRBA has been implicated in immune response and cell proliferation, and human LRBA mutations cause severe immune deficiency. Here, we report a first functional and molecular phenotype outside the immune system of LRBA-knockout mice: compromised olfaction, manifesting in reduced electro-olfactogram response amplitude, impaired food-finding efficiency, and smaller olfactory bulbs...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814763/spatial-genomic-heterogeneity-in-multiple-myeloma-revealed-by-multi-region-sequencing
#4
L Rasche, S S Chavan, O W Stephens, P H Patel, R Tytarenko, C Ashby, M Bauer, C Stein, S Deshpande, C Wardell, T Buzder, G Molnar, M Zangari, F van Rhee, S Thanendrarajan, C Schinke, J Epstein, F E Davies, B A Walker, T Meissner, B Barlogie, G J Morgan, N Weinhold
In multiple myeloma malignant plasma cells expand within the bone marrow. Since this site is well-perfused, a rapid dissemination of "fitter" clones may be anticipated. However, an imbalanced distribution of multiple myeloma is frequently observed in medical imaging. Here, we perform multi-region sequencing, including iliac crest and radiology-guided focal lesion specimens from 51 patients to gain insight into the spatial clonal architecture. We demonstrate spatial genomic heterogeneity in more than 75% of patients, including inactivation of CDKN2C and TP53, and mutations affecting mitogen-activated protein kinase genes...
August 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28813109/assessment-of-inhibitory-control-in-crack-and-or-cocaine-users-a-systematic-review
#5
Fernanda Rasch Czermainski, Alice Rodrigues Willhelm, Álvaro Zaneti Santos, Mayra Pacheco Pachado, Rosa Maria Martins de Almeida
Objective: Impairments involving inhibitory control have been considered central deficits in drug users, but it appears that dysfunctions may be specific to users' drug of choice. This article aims to review recent findings on inhibitory control impairment in samples of crack and/or cocaine users. Methods: Searches were conducted on the PubMed, PsycINFO, and Web of Knowledge databases in two stages according to eligibility criteria. Initially, databases were searched and the titles and abstracts of results were analyzed and then selected articles were read in full...
August 14, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28811351/content-and-construct-validity-reliability-and-responsiveness-of-the-rheumatoid-arthritis-flare-questionnaire-omeract-2016-workshop-report
#6
Susan J Bartlett, Skye P Barbic, Vivian P Bykerk, Ernest H Choy, Rieke Alten, Robin Christensen, Alfons den Broeder, Bruno Fautrel, Daniel E Furst, Francis Guillemin, Sarah Hewlett, Amye L Leong, Anne Lyddiatt, Lyn March, Pamela Montie, Christoph Pohl, Marieke Scholte Voshaar, Thasia G Woodworth, Clifton O Bingham
OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Flare Group was established to develop a reliable way to identify and measure RA flares in randomized controlled trials (RCT). Here, we summarized the development and field testing of the RA Flare Questionnaire (RA-FQ), and the voting results at OMERACT 2016. METHODS: Classic and modern psychometric methods were used to assess reliability, validity, sensitivity, factor structure, scoring, and thresholds...
August 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28810395/rasch-analysis-of-the-perceived-stress-scale-transformation-from-an-ordinal-to-a-linear-measure
#7
Oleg N Medvedev, Christian U Krägeloh, Erin M Hill, Rex Billington, Richard J Siegert, Craig S Webster, Roger J Booth, Marcus A Henning
Rasch analysis was conducted to enhance the precision of the widely used 10-item Perceived Stress Scale using two datasets ( n = 450 each) randomly selected from samples of the New Zealand general population ( n = 1102), New Zealand university students ( n = 479) and US university students ( n = 396). The best Rasch model fit ( χ(2)(27) = 29.92, p = .36), good person separation reliability (.80) and coverage (98%) of the sample by the scale items were achieved when locally dependent items were combined into subtests...
January 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28808772/longitudinal-strain-assessed-by-cardiac-magnetic-resonance-correlates-to-hemodynamic-findings-in-patients-with-severe-aortic-stenosis-and-predicts-positive-remodeling-after-transcatheter-aortic-valve-replacement
#8
Dominik Buckert, Maciej Cieslik, Raid Tibi, Michael Radermacher, Volker Rasche, Peter Bernhardt, Vinzenz Hombach, Wolfgang Rottbauer, Jochen Wöhrle
AIMS: To assess left-ventricular strain parameters before and after transcatheter aortic valve replacement (TAVR) by feature tracking cardiac magnetic resonance imaging (FT CMR) and to correlate the findings to hemodynamic state and left-ventricular remodeling. METHODS AND RESULTS: Patients with symptomatic AS underwent FT CMR before and after TAVR. Patients were carefully evaluated by a comprehensive work-up including CMR, echocardiography and left and right heart catheterization...
August 14, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28807029/development-of-a-new-rasch-based-scoring-algorithm-for-the-national-eye-institute-visual-functioning-questionnaire-to-improve-its-interpretability
#9
Jennifer Petrillo, Neil M Bressler, Ecosse Lamoureux, Alberto Ferreira, Stefan Cano
BACKGROUND: The NEI VFQ-25 has undergone psychometric evaluation in patients with varying ocular conditions and the general population. However, important limitations which may affect the interpretation of clinical trial results have been previously identified, such as concerns with reliability and validity. The purpose of this study was to evaluate the National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) and make recommendations for a revised scoring structure, with a view to improving its psychometric performance and interpretability...
August 14, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28796392/natural-history-of-charcot-marie-tooth-disease-during-childhood
#10
Kayla Md Cornett, Manoj P Menezes, Rosemary R Shy, Isabella Moroni, Emanuela Pagliano, Davide Pareyson, Timothy Estilow, Sabrina W Yum, Trupti Bhandari, Francesco Muntoni, Matilde Laura, Mary M Reilly, Richard S Finkel, Kate J Eichinger, David N Herrmann, Paula Bray, Mark Halaki, Michael E Shy, Joshua Burns
OBJECTIVE: To determine the rate of disease progression in a longitudinal natural history study of children with Charcot-Marie-Tooth disease (CMT). METHODS: 206 (103 female) participants aged 3-20 years enrolled in the Inherited Neuropathies Consortium were assessed at baseline and 2-years. Demographic, anthropometric, and diagnostic information were collected. Disease progression was assessed with the CMT Pediatric Scale (CMTPedS), a reliable Rasch-built linearly weighted disability scale evaluating fine and gross motor function, strength, sensation, and balance...
August 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28789656/the-national-eye-institute-25-item-visual-function-questionnaire-nei-vfq-25-reference-data-from-the-german-population-based-gutenberg-health-study-ghs
#11
Stefan Nickels, Alexander K Schuster, Susanne Singer, Philipp S Wild, Dagmar Laubert-Reh, Andreas Schulz, Robert P Finger, Matthias Michal, Manfred E Beutel, Thomas Münzel, Karl J Lackner, Norbert Pfeiffer
BACKGROUND: To estimate the burden of diseases, it is important to consider patient-reported outcomes including Quality of Life (QoL). The aim of this study is to provide population-based reference data for the National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25), stratified by sex and age. METHODS: The Gutenberg Health Study (GHS) is a population-based, prospective, observational cohort study in Germany, including 15,010 participants aged between 35 and 74...
August 8, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28777777/validation-of-catquest-9sf-a-visual-disability-instrument-to-evaluate-patient-function-after-corneal-transplantation
#12
Margareta Claesson, W John Armitage, Berit Byström, Per Montan, Branka Samolov, Ulf Stenvi, Mats Lundström
PURPOSE: Catquest-9SF is a 9-item visual disability questionnaire developed for evaluating patient-reported outcome measures after cataract surgery. The aim of this study was to use Rasch analysis to determine the responsiveness of Catquest-9SF for corneal transplant patients. METHODS: Patients who underwent corneal transplantation primarily to improve vision were included. One group (n = 199) completed the Catquest-9SF questionnaire before corneal transplantation and a second independent group (n = 199) completed the questionnaire 2 years after surgery...
September 2017: Cornea
https://www.readbyqxmd.com/read/28777686/a-non-parametric-item-response-theory-evaluation-of-the-cage-instrument-among-older-adults
#13
Edimansyah Abdin, Vathsala Sagayadevan, Janhavi Ajit Vaingankar, Louisa Picco, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: The validity of the CAGE using item response theory (IRT) has not yet been examined in older adult population. OBJECTIVE: This study aims to investigate the psychometric properties of the CAGE using both non-parametric and parametric IRT models, assess whether there is any differential item functioning (DIF) by age, gender and ethnicity and examine the measurement precision at the cut-off scores. METHODS: We used data from the Well-being of the Singapore Elderly study to conduct Mokken scaling analysis (MSA), dichotomous Rasch and 2-parameter logistic IRT models...
August 4, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28776784/the-international-phase-4-validation-study-of-the-eortc-qlq-swb32-a-stand-alone-measure-of-spiritual-well-being-for%C3%A2-people-receiving-palliative-care-for-cancer
#14
B Vivat, T E Young, J Winstanley, J I Arraras, K Black, F Boyle, A Bredart, A Costantini, J Guo, M E Irarrazaval, K Kobayashi, R Kruizinga, M Navarro, S Omidvari, G E Rohde, S Serpentini, N Spry, H W M Van Laarhoven, G M Yang
The EORTC Quality of Life Group has just completed the final phase (field-testing and validation) of an international project to develop a stand-alone measure of spiritual well-being (SWB) for palliative cancer patients. Participants (n = 451)-from 14 countries on four continents; 54% female; 188 Christian; 50 Muslim; 156 with no religion-completed a provisional 36-item measure of SWB plus the EORTC QLQ-C15-PAL (PAL), then took part in a structured debriefing interview. All items showed good score distribution across response categories...
August 4, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28774966/complete-genome-sequence-of-citrobacter-freundii-myophage-mijalis
#15
Sruti Parvataneni, Eleni M Mijalis, Gabriel F Kuty Everett, Eric S Rasche, Mei Liu, Jason J Gill
Citrobacter freundii is responsible for various opportunistic nosocomial infections. Phage therapies against C. freundii may prove useful in human medicine for treatment of infections caused by the ubiquitous bacteria. Here, we announce the complete genome sequence of the C. freundii Felix O1-like myophage Mijalis and present its features.
August 3, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28770616/examining-the-basc-3-bess-parent-form-preschool-using-rasch-methodology
#16
Christine DiStefano, Fred W Greer, Erin Dowdy
This study examined the Behavior Assessment System for Children-Third Edition Behavioral and Emotional Screening System, Parent Form-Preschool, which is used to identify children at risk for emotional/behavioral problems. Rasch rating scale methods were used to provide information about psychometric properties of items, parent raters, and the response scale. Using the norming sample of 459 children, we investigated the structure of the screener, performance of the scale, and coverage of the maladaptive behavior construct to identify children with emerging behavioral difficulties...
August 1, 2017: Assessment
https://www.readbyqxmd.com/read/28765250/validating-rheumatoid-arthritis-remission-using-the-patients-perspective-results-from-a-special-interest-group-at-omeract-2016
#17
Linda A Rasch, Maarten Boers, Catherine L Hill, Marieke Voshaar, Wijnanda Hoogland, Maarten de Wit, Caroline Flurey, Bev Davis, Merete Lund Hetland, Cecilie Heegaard Brahe, Laure Gossec, George A Wells, Peter Tugwell, Bindee Kuriya, Niti Goel, Jasvinder A Singh, Cátia Duarte, José Da Silva, Dirkjan van Schaardenburg, Susanna Proudman, Lilian H D van Tuyl
OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) working group on the patients' perspective on remission in rheumatoid arthritis (RA) has been working on this topic since 2010. At OMERACT 2016, progress and preliminary data on validity of measurement instruments for pain, fatigue, and independence in remission in RA were presented, and future directions were explored. METHODS: A special interest group was organized, in which the current data on the patients' perspective on remission were presented...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28763063/aripiprazole-and-riluzole-treatment-alters-behavior-and-neurometabolites-in-young-adhd-rats-a-longitudinal-1-h-nmr-spectroscopy-study-at-11-7t
#18
F Rizzo, A Abaei, E Nespoli, J M Fegert, B Hengerer, V Rasche, T M Boeckers
Attention deficit hyperactivity disorder (ADHD), Tourette syndrome (TS) as well as obsessive compulsive disorder (OCD) are co-occurring neurodevelopmental diseases that share alterations of frontocortical neurometabolites. In this longitudinal study we investigated the behavioral and neurochemical effects of aripiprazole and riluzole treatment in juvenile spontaneously hypertensive rats (SHR), a model for ADHD. For neurochemical analysis we employed in vivo magnetic resonance spectroscopy (MRS). Spectra from voxels located at the central striatum and prefrontal cortex were acquired postnatally from day 35 to 50...
August 1, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28762380/rasch-measurement-properties-of-the-pain-medication-questionnaire-in-persons-with-spinal-cord-injury
#19
B N Hand, C A Velozo, J S Krause
STUDY DESIGN: Secondary analysis of cross-sectional population-based self-report data. OBJECTIVE: To determine how well the Pain Medication Questionnaire (PMQ) measures risk of pain medication misuse and its precision in separating individuals with spinal cord injury (SCI) into meaningful classification categories. SETTING: Academic medical center in Southeastern United States. METHODS: Data were collected from a population-based registry of SCI (n=971)...
August 1, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28762236/conceptualisation-development-and-validation-of-t-qol%C3%A2-teenagers-quality-of-life-a-patient-focused-measure-to-assess-quality-of-life-of-adolescents-with-skin-diseases
#20
M K A Basra, M S Salek, D Fenech, A Y Finlay
AIM: To develop and validate a dermatology-specific quality of life (QoL) instrument for adolescents with skin diseases. METHODS: Qualitative semi-structured interviews were conducted with adolescents with skin disease to gain in-depth understanding of how skin diseases affect their QoL. A prototype instrument based on the themes identified from content analysis of interviews was tested in several stages, using Classical Test Theory (CTT) and Item Response Theory (IRT) models to develop this new tool and conduct its psychometric evaluation...
July 31, 2017: British Journal of Dermatology
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