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JOURNAL ARTICLE
Yina Wang, Weijiao Feng, Jie Peng, Fen Ye, Jun Song, Xiaoyan Bao, Chaosheng Li
BACKGROUND: Aspiration is a frequently observed complication in individuals diagnosed with acute ischemic stroke, leading to potentially severe consequences. However, the availability of predictive tools for assessing aspiration probabilities remains limited. Hence, our study aimed to develop and validate a nomogram for accurately predicting aspiration probability in patients with acute ischemic stroke. METHODS: We analyzed 30 potential risk factors associated with aspiration in 359 adult patients diagnosed with acute ischemic stroke...
April 22, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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JOURNAL ARTICLE
Magdalena Osiewicz, Bartosz Ciapała
BACKGROUND: Temporomandibular disorders (TMD) affect the masticatory muscles, temporomandibular joints (TMJs) and associated structures. The relationship between occlusion and TMD is a contentious issue in the dental field. OBJECTIVES: Although there is a strong argument against invasive and irreversible therapeutic TMD procedures, the TMD biopsychosocial model is still not accepted by some clinicians. Hence, this study aimed to verify whether malocclusions are related to TMD pain...
April 23, 2024: Dental and Medical Problems
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JOURNAL ARTICLE
Alper Ozdogan, Büsra Tosun
BACKGROUND: As polyether ether ketone (PEEK) is a relatively new material in dentistry, its bonding properties with regard to dental acrylic base materials are not fully known. To ensure the long-term success of removable dentures with a PEEK framework, the base materials must be well bonded to each other. OBJECTIVES: The study aimed to investigate the effects of different kinds of surface roughening treatment on PEEK and acrylic resin bonding. MATERIAL AND METHODS: Eighty PEEK specimens (N = 80) were randomly divided into 5 groups (n = 16 per group) and subjected to various surface roughening treatment (control, grinding, sandblasting, tribochemical silica coating (CoJet), and sulfuric acid etching)...
2024: Dental and Medical Problems
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JOURNAL ARTICLE
Risa Kagan, James A Simon, Steven R Goldstein, Barry S Komm, Simon N Jenkins, David J Portman
OBJECTIVE: The aim of this study was to demonstrate whether lasofoxifene improves vaginal signs/symptoms of genitourinary syndrome of menopause. METHODS: Two identical, phase 3 trials randomized postmenopausal women with moderate to severe vaginal symptoms to oral lasofoxifene 0.25 or 0.5 mg/d, or placebo, for 12 week. Changes from baseline to week 12 in most bothersome symptom, vaginal pH, and percentages of vaginal parabasal and superficial cells were evaluated...
April 23, 2024: Menopause: the Journal of the North American Menopause Society
#5
JOURNAL ARTICLE
Alexandre Mendes de Almeida Junior, André Satoshi Ferreira, Sabrina Aléssio Camacho, Lucas Gontijo Moreira, Karina Alves de Toledo, Osvaldo N Oliveira, Pedro Henrique Benites Aoki
Phototherapies are promising for noninvasive treatment of aggressive tumors, especially when combining heat induction and oxidative processes. Herein, we show enhanced phototoxicity of gold shell-isolated nanorods conjugated with toluidine blue-O (AuSHINRs@TBO) against human colorectal tumor cells (Caco-2) with synergic effects of photothermal (PTT) and photodynamic therapies (PDT). Mitochondrial metabolic activity tests (MTT) performed on Caco-2 cell cultures indicated a photothermal effect from AuSHINRs owing to enhanced light absorption from the localized surface plasmon resonance (LSPR)...
April 23, 2024: ACS Applied Materials & Interfaces
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JOURNAL ARTICLE
Makiko Go, Michio Kimura, Shiori Yamada, Eiseki Usami, Yoshihiro Noguchi, Tomoaki Yoshimura
Background : Appropriate adverse event (AE) management and maintenance of therapeutic intensity are necessary to achieve therapeutic benefits of CDK4/6 inhibitors (palbociclib and abemaciclib) in hormone receptor-positive, HER2-negative metastatic/recurrent breast cancer. Objective : This study was aimed at clarifying the effect of AEs associated with palbociclib and abemaciclib on treatment. Methods : A total of 62 and 49 patients were prescribed palbociclib and abemaciclib, respectively, at our hospital from January 1, 2018 to June 30, 2023...
April 23, 2024: Journal of Pharmacy Practice
#7
JOURNAL ARTICLE
M Patrice Eiff, Annie Ericson, Dang H Dinh, Steele Valenzuela, Colleen Conry, Alan B Douglass, W Perry Dickinson, Stephanie E Rosener, Patricia A Carney
BACKGROUND AND OBJECTIVES: Factors associated with physician practice choice include residency location, training experiences, and financial incentives. How length of training affects practice setting and clinical care features postgraduation is unknown. METHODS: In this Length of Training Pilot (LoTP) study, we surveyed 366 graduates of 3-year (3YR) and 434 graduates of 4-year (4YR) programs 1 year after completion of training between 2013 and 2021. Variables assessed included reasons for practice setting choice, practice type, location, practice and community size, specialty mix, and clinical care delivery features (eg, integrated behavioral health, risk stratified care management)...
April 12, 2024: Family Medicine
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JOURNAL ARTICLE
Sean Doherty, Payal Agarwal, Ri Wang, Christopher Meaney, Kirsten Eldridge, Ali N Damji, Debbie Elman, Susanna Fung, Karuna L Gupta, Sakina Walji, Linda Weber, Melissa Witty, Tara Kiran
BACKGROUND AND OBJECTIVES: We compared experiences of patients who reported usually being seen by a resident with those usually seen by a staff physician. METHODS: We analyzed responses to a patient experience survey distributed at 13 family medicine teaching practices affiliated with the University of Toronto between May and June 2020. We analyzed responses to seven questions pertaining to timely access, continuity, and patient-centeredness. We compared responses between two types of usual primary care clinicians and calculated odds ratios before and after adjustment for patient characteristics...
April 2, 2024: Family Medicine
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JOURNAL ARTICLE
Monica Vaccari, Stefania Serra, Andrea Ranzi, Federico Aldrovandi, Giangabriele Maffei, Maria G Mascolo, Ada Mescoli, Elisa Montanari, Gelsomina Pillo, Francesca Rotondo, Ivan Scaroni, Lorenzo Vaccari, Cristina Zanzi, Tony Fletcher, Martin Paparella, Annamaria Colacci
Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are the major components of long-chain per- and polyfluorinated alkyl substances (PFAS), known for their chemical stability and environmental persistence. Even if PFOA and PFOS have been phased out or are limited in use, they still represent a concern for human and environmental health. Several studies have been performed to highlight the toxicological behavior of these chemicals and their mode of action (MoA). Data suggested the causal association between PFOA or PFOS exposure and carcinogenicity in humans, but the outcomes of epidemiological studies showed some inconsistency...
April 22, 2024: ALTEX
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JOURNAL ARTICLE
Stefan Niederauer, Mike Beeman, Andrew Cleveland, Susan Wojtalewicz, Sierra Erickson, Christopher A Reilly, Joseph E Rower, Caroline Garrett, Candace Floyd, Jill Shea, Jay Agarwal, Caleb Lade, Brett Davis
BACKGROUND: Partial-thickness skin wounds are some of the most painful injuries due to large areas of exposed nerve endings. These injuries often require systemic opioid treatments to manage pain adequately. However, in 2021 alone, the CDC reported nearly 17,000 prescription opioid-related deaths in the USA, highlighting the ongoing need for non-opioid treatment strategies. In this manuscript, we developed a novel single-application ropivacaine-eluting primary wound dressing that could provide sustained ropivacaine delivery to partial-thickness wounds and assessed its in vivo feasibility for prolonged non-opioid analgesia...
April 23, 2024: Plastic and Reconstructive Surgery
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JOURNAL ARTICLE
Ben Auxier, Jianhua Zhang, Francisca Reyes Marquez, Kira Senden, Joost van den Heuvel, Duur K Aanen, Eveline Snelders, Alfons J M Debets
In fungi, fusion between individuals leads to localized cell death, a phenomenon termed heterokaryon incompatibility. Generally, the genes responsible for this incompatibility are observed to be under balancing selection resulting from negative frequency-dependent selection. Here, we assess this phenomenon in Aspergillus fumigatus, a human pathogenic fungus with a very low level of linkage disequilibrium as well as an extremely high crossover rate. Using complementation of auxotrophic mutations as an assay for hyphal compatibility, we screened sexual progeny for compatibility to identify genes involved in this process, called het genes...
April 23, 2024: Molecular Biology and Evolution
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JOURNAL ARTICLE
Nilay Bektas Akpinar, Ulviye Özcan Yüce, Gizem Cansız, Dilek Yurtsever, Cemaynur Özkanat, Nursemin Unal, Cengiz Sabanoglu, Özlem Altınbas Akkas, Sabire Yurtsever
AIMS: The aim of this study was to examine the effect of Reiki in patients with cardiac disease. METHODS AND RESULTS: This study was a single-blind, pre-post-test, randomized, placebo-controlled study. Patients from the cardiology outpatient clinic of a training and research hospital were randomized into three groups: Reiki (n = 22), sham (placebo) (n = 21), and control (no treatment) (n = 22). Data were collected using a personal information form, biochemical parameters, cortisol levels, Beck Anxiety Inventory, and electrocardiography analysis...
April 23, 2024: European Journal of Cardiovascular Nursing
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JOURNAL ARTICLE
Wolfgang Stroebe
Roberts and colleagues focus on two aspects of racial inequality in psychological research, namely an alleged underrepresentation of racial minorities and the effects attributed to this state of affairs. My comment focuses only on one aspect, namely the assumed consequences of the lack of diversity in subject populations. Representativeness of samples is essential in survey research or applied research that examines whether a particular intervention will work for a particular population. Representativeness or diversity is not necessary in theory-testing research, where we attempt to establish laws of causality...
May 2024: Perspectives on Psychological Science
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JOURNAL ARTICLE
Lauren Griffin, Mark Richard Stephen Garren, Patrick Maffe, Sama Ghalei, Elizabeth J Brisbois, Hitesh Handa
Of the 27 million surgeries performed in the United States each year, a reported 2.6% result in a surgical site infection (SSI), and Staphylococci species are commonly the culprit. Alternative therapies, such as nitric oxide (NO)-releasing biomaterials, are being developed to address this issue. NO is a potent antimicrobial agent with several modes of action, including oxidative and nitrosative damage, disruption of bacterial membranes, and dispersion of biofilms. For targeted antibacterial effects, NO is delivered by exogenous donor molecules, like S -nitroso- N -acetylpenicillamine (SNAP)...
April 23, 2024: ACS Applied Bio Materials
#15
JOURNAL ARTICLE
Jian Zhu, Yunyan Lai, Yinhua Wu, Jiali Wang, Jiaqi Wei, Hanhong Xu
We screened the contact activity of 32 commercial essential oils (EOs) and their synergistic effect with β-cypermethrin against Blattella germanica . Results showed that the most effective EOs against B. germanica were from Illicium verum , Syzygium aromaticum , and Cinnamomum camphora , with LD50 values of less than 500 μg/insect. The most potent synergistic effects of β-cypermethrin on B. germanica were from Dysphania ambrosioides and Mentha canadensis . Both oils have a co-toxic factor of 133...
April 23, 2024: Journal of Agricultural and Food Chemistry
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JOURNAL ARTICLE
Sushant Sharma Chaudhary, Andrew Toivonen, Gaurav Waratkar, Geoffrey Mo, Deep Chatterjee, Sarah Antier, Patrick Brockill, Michael W Coughlin, Reed Essick, Shaon Ghosh, Soichiro Morisaki, Pratyusava Baral, Amanda Baylor, Naresh Adhikari, Patrick Brady, Gareth Cabourn Davies, Tito Dal Canton, Marco Cavaglia, Jolien Creighton, Sunil Choudhary, Yu-Kuang Chu, Patrick Clearwater, Luke Davis, Thomas Dent, Marco Drago, Becca Ewing, Patrick Godwin, Weichangfeng Guo, Chad Hanna, Rachael Huxford, Ian Harry, Erik Katsavounidis, Manoj Kovalam, Alvin K Y Li, Ryan Magee, Ethan Marx, Duncan Meacher, Cody Messick, Xan Morice-Atkinson, Alexander Pace, Roberto De Pietri, Brandon Piotrzkowski, Soumen Roy, Surabhi Sachdev, Leo P Singer, Divya Singh, Marek Szczepanczyk, Daniel Tang, Max Trevor, Leo Tsukada, Verónica Villa-Ortega, Linqing Wen, Daniel Wysocki
Multimessenger searches for binary neutron star (BNS) and neutron star-black hole (NSBH) mergers are currently one of the most exciting areas of astronomy. The search for joint electromagnetic and neutrino counterparts to gravitational wave (GW)s has resumed with ALIGO's, AdVirgo's and KAGRA's fourth observing run (O4). To support this effort, public semiautomated data products are sent in near real-time and include localization and source properties to guide complementary observations. In preparation for O4, we have conducted a study using a simulated population of compact binaries and a mock data challenge (MDC) in the form of a real-time replay to optimize and profile the software infrastructure and scientific deliverables...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#17
JOURNAL ARTICLE
Wei-Hsin Hsu, Kai-Wen Cheng, Tzu-Hsuan Feng, Ju-Yu Chen, Guan-Yuan Chen, Lian-Yu Chen, Te I Weng, Cheng-Chih Hsu
Drug abuse is a severe social problem worldwide. Particularly, the issue of new psychoactive substances (NPSs) have increasingly emerged. NPSs are structural or functional analogs of traditional illicit drugs, such as cocaine, cannabis, and amphetamine; these molecules provide the same or more severe neurological effects. Usually, immunoassays are utilized in the preliminary screening method. However, NPSs have poor detectability in commercially available immunoassay kits. Meanwhile, various chromatography combined with the mass spectrometry platform have been developed to quantify NPSs...
April 23, 2024: Journal of the American Society for Mass Spectrometry
#18
JOURNAL ARTICLE
Stefan Popp, Anna Dornhaus
Collectively searching animals might be expected to coordinate with their groupmates to cover ground more evenly or efficiently than uncoordinated groups. Communication can lead to coordination in many ways. Previous work in ants suggests that chemical 'footprints', left behind by individuals as they walk, might serve this function by modulating the movement patterns of following ants. Here, we test this hypothesis by considering the two predictions that, first, ants may turn away from sites with higher footprint concentrations (klinotaxis), or, second, that they may change their turning patterns depending on the presence of footprints (klinokinesis)...
2024: PloS One
#19
JOURNAL ARTICLE
Magnus Jutell, Shakura Bhat, Maria Lindstrom Bagge, Per-Erik Isberg, Nana Wiberg
Worldwide vitamin D insufficiency is remarkably prevalent in both children and adults, including pregnant women. The total amount of the vitamin is best measured by 25-hydroxy-vitamin D (25(OH)D), which is a measurement of total serum cholecalciferol 25(OH)D3 and ergocalciferol 25(OH)D2. There is a known correlation between maternal and umbilical cord blood (UCB) 25(OH)D; however, whether specific maternal demographics or comorbidities influence the correlation remains uncertain. This prospective observational study was designed to study if maternal 25(OH)D levels, maternal age and BMI, amount of supplementation, mode of delivery, diabetes, hypertension/preeclampsia, or sunlight exposure had an impact on the correlation...
2024: PloS One
#20
JOURNAL ARTICLE
Maryam Motamedi, Jessica Dawson, Na Li, Douglas G Down, Nancy M Heddle
Platelet products are both expensive and have very short shelf lives. As usage rates for platelets are highly variable, the effective management of platelet demand and supply is very important yet challenging. The primary goal of this paper is to present an efficient forecasting model for platelet demand at Canadian Blood Services (CBS). To accomplish this goal, five different demand forecasting methods, ARIMA (Auto Regressive Integrated Moving Average), Prophet, lasso regression (least absolute shrinkage and selection operator), random forest, and LSTM (Long Short-Term Memory) networks are utilized and evaluated via a rolling window method...
2024: PloS One
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