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https://www.readbyqxmd.com/read/29232800/-a-case-of-fulminant-hepatitis-after-administration-of-abiraterone-acetate
#1
Satoru Yumiba, Kazuhiko Komori, Toshichika Iwanishi, Youhei Koida, Masao Kobayashi, Yutaka Ono
A 77-year-old man with castration-resistant prostate cancer (CRPC) received abiraterone acetate in October 2014. He visited our outpatient clinic because of general malaise and anorexia 27 days after starting abiraterone acetate. The lab test showed hepatic dysfunction (aspartate transaminase, AST 440 U/l, alanine transaminase, ALT 420 U/l) and the elevation of liver enzymes continued on the next day even after stopping abiraterone acetate. Three days later, he was hospitalized due to severe elevation of liver enzymes (AST 1,171 U/l, ALT 1,487 U/l) , and the decreased prothrombin activity (60...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29232766/combined-erlotinib-and-pf-03084014-treatment-contributes-to-synthetic-lethality-in-head-and-neck-squamous-cell-carcinoma
#2
Yang Zheng, Zhao Wang, Xu Ding, Yibo Dong, Wei Zhang, Wei Zhang, Yi Zhong, Wenyi Gu, Yunong Wu, Xiaomeng Song
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) is characterized by high mortality and low survival rates. As an epidermal growth factor receptor (EGFR) inhibitor, Erlotinib has been approved for treatment of various tumours. PF-03084014 is a selective inhibitor of Notch1 signalling. This study aimed to explore new approaches for simultaneously targeting EGFR and Notch1 signalling to attenuate tumour growth and improve survival. MATERIALS AND METHODS: Cell proliferation was determined by CCK-8 assay and Flow cytometry...
December 12, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29232762/review-article-best-practice-management-of-low-back-pain-in-the-emergency-department-part-1-of-the-musculoskeletal-injuries-rapid-review-series
#3
REVIEW
Kirsten Strudwick, Megan McPhee, Anthony Bell, Melinda Martin-Khan, Trevor Russell
Low back pain (LBP) is a common presentation to the ED, and a frequent cause of disability globally. The ED management is often associated with high rates of imaging, misuse and overuse of pharmacology and subsequent financial implications. Given this, improved quality of care for patients with LBP in ED is essential. This rapid review investigated best practice for the assessment and management of LBP in the ED. PubMed, CINAHL, EMBASE, TRIP and the grey literature, including relevant organisational websites, were searched in 2015...
December 12, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29232754/-measurement-of-the-strength-of-human-musculus-orbicularis-oculi-using-video-analysis
#4
Anita Koschmieder, Phillip Pisowocki, Carmen Zietz, Rainer Bader, Oliver Stachs, Anselm Jünemann
Introduction Current methods to measure the of strength of the musculus orbicularis oculi are limited by high proneness to examiner error or by their complex and impracticable set-ups. Our aim was to develop a simple and practicable method to measure eye lid power via video analysis. Methods 50 healthy subjects were included. A deformable single use lid speculum was used. Forced maximum lid closure was recorded via a video slit lamp. Analysis of the video data was performed with open source tracking software...
December 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29232727/-radial-head-fracture-management-recommendations
#5
Markus Gühring, Ulrich Stöckle, Patrick Ziegler
The radial head is pivotal in the functional anatomy of the elbow and forearm. It is an important stabiliser, together with the collateral ligaments and the processus coronoideus. Due to the pivotal importance, optimal therapies are essential for the function of elbow and forearm, independently of trauma severity. The present article presents current diagnostic testing, classifications and treatment options for radial head fractures.
December 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29232724/inter-rater-reliability-of-air-saline-hycosy-hyfosy-and-hyfosy-combined-with-power-doppler-for-screening-tubal-patency
#6
Inga Ludwin, Artur Ludwin, Carolina O Nastri, Marcela A Coelho Neto, Jan Kottner, Wellington P Martins
Purpose To estimate the inter-observer reliability and agreement of offline analyses of three different ultrasound techniques for assessing tubal patency. Methods 100 tubes (n = 100) in 50 women were evaluated for tubal patency between November 2013 and July 2015 using ultrasound as index tests and laparoscopy as the reference standard. Three different ultrasound techniques were applied: two-dimensional grayscale ultrasound using air + saline as the contrast media (2D-HyCoSy); two- and three-dimensional grayscale ultrasound using foam as the contrast media (2 D/3D-HyFoSy); and the same technique but adding bi-directional power Doppler (2 D/3D-Doppler-HyFoSy)...
December 12, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29232714/cytomegalovirus-cmv-immune-monitoring-with-elispot-and-quantiferon-cmv-assay-in-seropositive-kidney-transplant-recipients
#7
Hyeyoung Lee, Ki Hyun Park, Ji Hyeong Ryu, Ae-Ran Choi, Ji Hyun Yu, Jihyang Lim, Kyungja Han, Sang Il Kim, Chul Woo Yang, Byung Ha Chung, Eun-Jee Oh
Although cytomegalovirus (CMV) specific cell-mediated immunity (CMI) has been suggested as a predictive marker for CMV infection, proper CMI monitoring strategy in CMV-seropositive recipients and optimal method are not defined. The aim of this study was to evaluate two interferon gamma release assays during early post-transplant period as a predictor of the development of CMV infection in CMV-seropositive patients. A total of 124 CMV-seropositive recipients who received kidney transplantation from CMV-seropositive donor were prospectively examined...
2017: PloS One
https://www.readbyqxmd.com/read/29232711/dependence-of-prevalence-of-contiguous-pathways-in-proteins-on-structural-complexity
#8
Kelly M Thayer, Jesse C Galganov, Avram J Stein
Allostery is a regulatory mechanism in proteins where an effector molecule binds distal from an active site to modulate its activity. Allosteric signaling may occur via a continuous path of residues linking the active and allosteric sites, which has been suggested by large conformational changes evident in crystal structures. An alternate possibility is that the signal occurs in the realm of ensemble dynamics via an energy landscape change. While the latter was first proposed on theoretical grounds, increasing evidence suggests that such a control mechanism is plausible...
2017: PloS One
https://www.readbyqxmd.com/read/29232706/biventricular-differences-in-%C3%AE-adrenergic-receptor-signaling-following-burn-injury
#9
Ashley N Guillory, Robert P Clayton, Anesh Prasai, Amina El Ayadi, David N Herndon, Celeste C Finnerty
Burn injury detrimentally affects the myocardium, primarily due to over-activation of β-adrenergic receptors (β-AR). Autopsy reports from our institution reveal that patients often suffer from right ventricle (RV) failure. Since burn injury affects β-AR signaling in the left ventricle (LV), we proposed that β-AR signaling may also be altered in the RV. A rodent model with a scald burn of 60% of the total body surface area was used to test this hypothesis. Ventricles were isolated 7 days post-burn. We examined the expression of β-ARs via Western blotting and the mRNA expression of downstream signaling proteins via qRT-PCR...
2017: PloS One
https://www.readbyqxmd.com/read/29232694/hyperbranched-poly-%C3%AF%C2%B5-lysine-substrate-presenting-the-laminin-sequence-yigsr-induces-the-formation-of-spheroids-in-adult-bone-marrow-stem-cells
#10
Valeria Perugini, Steve T Meikle, Anna L Guildford, Matteo Santin
Unlike the fibroblast-like cells formed upon monolayer culture of human mesenchymal stem cells, the natural stem cell niche of the bone marrow and other types of tissues favours the formation of 3-dimensional (3D) cell clusters. The structuring and biological activity of these clusters are regulated by the contacts established by cells with both the basement membrane and neighbour cells and results in their asymmetric division and the consequent maintenance of both a stem population and a committed progeny...
2017: PloS One
https://www.readbyqxmd.com/read/29232693/host-factors-that-promote-retrotransposon-integration-are-similar-in-distantly-related-eukaryotes
#11
Sudhir Kumar Rai, Maya Sangesland, Michael Lee, Caroline Esnault, Yujin Cui, Atreyi Ghatak Chatterjee, Henry L Levin
Retroviruses and Long Terminal Repeat (LTR)-retrotransposons have distinct patterns of integration sites. The oncogenic potential of retrovirus-based vectors used in gene therapy is dependent on the selection of integration sites associated with promoters. The LTR-retrotransposon Tf1 of Schizosaccharomyces pombe is studied as a model for oncogenic retroviruses because it integrates into the promoters of stress response genes. Although integrases (INs) encoded by retroviruses and LTR-retrotransposons are responsible for catalyzing the insertion of cDNA into the host genome, it is thought that distinct host factors are required for the efficiency and specificity of integration...
December 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29232692/trachomatous-scarring-among-children-in-a-formerly-hyper-endemic-district-of-tanzania
#12
Jacob T Cox, Harran Mkocha, Beatriz Munoz, Sheila K West
BACKGROUND: Associations between repeated ocular infections with Chlamydia trachomatis in childhood and conjunctival scarring in adulthood are well established. Trachomatous scarring (TS) in children has also been observed in hyper-endemic areas, but data are scant regarding childhood scarring in areas where trachoma has been reduced to hypo-endemic levels. METHODS/PRINCIPLE FINDINGS: In this cross-sectional study, a random sample of children, ages 1-9 years, were selected from 38 communities in the formerly hyper-endemic district of Kongwa, Tanzania...
December 12, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29232691/effect-of-food-simulating-liquids-on-the-flexural-strength-of-a-methacrylate-and-silorane-based-composite
#13
Ehsan Mohammadi, Leila Pishevar, Parvin Mirzakouchaki Boroujeni
OBJECTIVE: The purpose of this study was to assess the effect of food-simulating liquids on the flexural strength of a methacrylate-based and a silorane-based resin composite. MATERIALS AND METHODS: In this in vitro study, sixty specimens of Filtek P90 and Filtek Z350 composite were prepared in a customized mold (2 × 2 × 25 mm). The specimens of each composite were divided into five subgroups as follows: one as a control group and the other four groups included distilled water, heptane, 2% citric acid, and 50% aqueous ethanol...
2017: PloS One
https://www.readbyqxmd.com/read/29232689/a-computational-model-for-regulation-of-nanoscale-glucan-exposure-in-candida-albicans
#14
Michael J Wester, Jia Lin, Aaron K Neumann
Candida albicans is a virulent human opportunistic pathogen. It evades innate immune surveillance by masking an immunogenic cell wall polysaccharide, β-glucan, from recognition by the immunoreceptor Dectin-1. Glucan unmasking by the antifungal drug caspofungin leads to changes in the nanostructure of glucan exposure accessible to Dectin-1. The physical mechanism that regulates glucan exposure is poorly understood, but it controls the nanobiology of fungal pathogen recognition. We created computational models to simulate hypothetical physical processes of unmasking glucan in a biologically realistic distribution of cell wall glucan fibrils...
2017: PloS One
https://www.readbyqxmd.com/read/29232679/clinicopathological-and-prognostic-features-of-surgical-management-in-duodenal-gastrointestinal-stromal-tumors
#15
Hong Peng Shi, Min Lu Huang, Zhen Qiang Wang, Ya Nan Zheng, Zheng Lun Zhu, Birendra Kumar Sah, Wen Tao Liu, Min Yan, Zheng Gang Zhu, Chen Li
BACKGROUND AND OBJECTIVES: The rarity of duodenal gastrointestinal stromal tumors (DGIST) led to only limited data being available on their management and prognosis. We retrospectively analyzed the clinicopathological features, surgical treatments, adjuvant therapy, and prognosis of DGIST. METHODS: Sixty-one patients were identified at diagnosis of primary DGIST from February 2005 to December 2015. One hundred twenty six patients with small intestinal gastrointestinal stromal tutors (GIST) were selected as control groups...
December 12, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29232675/evaluation-of-novel-anticaries-adhesive-in-a-secondary-caries-animal-model
#16
Tianmu Wu, Bolei Li, Xuedong Zhou, Yao Hu, Huajin Zhang, Yingkang Huang, Hockin H K Xu, Qiang Guo, Mingyun Li, Mingye Feng, Xian Peng, Michael D Weir, Lei Cheng, Biao Ren
We investigated the anticaries properties of an adhesive containing dimethylaminododecyl methacrylate (DMADDM) in vivo via a secondary caries animal model. Cavities were prepared in the maxillary first molars of Wistar rats. DMADDM-containing adhesives were applied on one side and commercial adhesives on the opposite side as a control. After a 3-week feeding period to induce secondary caries, the molars were harvested for the evaluation of the secondary caries. Lesion depth (LD) and mineral loss (ML) were measured via a micro-CT method, and a modified Keyes scoring method yielded scores for the caries lesions...
December 13, 2017: Caries Research
https://www.readbyqxmd.com/read/29232669/implication-of-haemodiafiltration-flow-rate-on-amikacin-pharmacokinetic-parameters-in-critically-ill-patients
#17
Jesús Ruiz-Ramos, Esther Villarreal, Mónica Gordon, María Martin-Cerezula, Maria Jesús Broch, María Remedios Marqués, Jose Luis Poveda, Álvaro Castellanos-Ortega, Paula Ramírez
BACKGROUND: To analyse the effect of haemodiafiltration (CVVHDF) flow rate on amikacin pharmacokinetics and blood concentrations. METHODS: Prospective observational study. Patients receiving CVVHDF and amikacin treatment were included. Pharmacokinetic parameters were calculated using Bayesian analysis. Spearman correlation test was used in order to assess the influence of CVVHDF flux on amikacin minimum concentration (Cmin) and plasma clearance. RESULTS: Thirty patients undergoing CVVHDF procedures were included...
December 12, 2017: Blood Purification
https://www.readbyqxmd.com/read/29232666/validation-of-the-hebrew-version-of-the-eating-assessment-tool-10-h-eat-10
#18
Sara Abu-Ghanem, Melissa Schechter, Hanna Flesh-Eyni, Liat Litwin, Esti Makai, Yael Oestreicher-Kedem, Moshe Yehuda
BACKGROUND AND OBJECTIVES: Dysphagia is a common disability with different etiologies. In order to measure dysphagia symptom severity and effects on quality of life, the Eating Assessment Tool (EAT-10) was developed and validated in the English language. We aimed to develop a Hebrew version of the EAT-10 and to evaluate its internal consistency, test-retest reliability, and validity in Hebrew-speaking adults with dysphagia. SUBJECTS AND METHODS: The Hebrew EAT-10 (H-EAT-10) questionnaire was completed by 132 patients: 56 patients with dysphagia and 76 controls...
December 12, 2017: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/29232650/internal-validation-of-two-new-retrotransposons-based-kits-innoquant%C3%A2-hy-and-innotyper%C3%A2-21-at-a-forensic-lab
#19
Cátia Martins, Paulo Miguel Ferreira, Raquel Carvalho, Sandra Cristina Costa, Carlos Farinha, Luísa Azevedo, António Amorim, Manuela Oliveira
Obtaining a genetic profile from pieces of evidence collected at a crime scene is the primary objective of forensic laboratories. New procedures, methods, kits, software or equipment must be carefully evaluated and validated before its implementation. The constant development of new methodologies for DNA testing leads to a steady process of validation, which consists of demonstrating that the technology is robust, reproducible, and reliable throughout a defined range of conditions. The present work aims to internally validate two new retrotransposon-based kits (InnoQuant® HY and InnoTyper® 21), under the working conditions of the Laboratório de Polícia Científica da Polícia Judiciária (LPC-PJ)...
November 29, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29232649/multi-hypothesis-tracking-of-the-tongue-surface-in-ultrasound-video-recordings-of-normal-and-impaired-speech
#20
Catherine Laporte, Lucie Ménard
Characterizing tongue shape and motion, as they appear in real-time ultrasound (US) images, is of interest to the study of healthy and impaired speech production. Quantitative anlaysis of tongue shape and motion requires that the tongue surface be extracted in each frame of US speech recordings. While the literature proposes several automated methods for this purpose, these either require large or very well matched training sets, or lack robustness in the presence of rapid tongue motion. This paper presents a new robust method for tongue tracking in US images that combines simple tongue shape and motion models derived from a small training data set with a highly flexible active contour (snake) representation and maintains multiple possible hypotheses as to the correct tongue contour via a particle filtering algorithm...
December 5, 2017: Medical Image Analysis
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