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BACKGROUND: Poland, Czech Republic, and the Slovak Republic are countries with high alcohol consumption, and alcohol-induced disorders are in the ten leading causes of Years Lost due to Disability. Therefore it is necessary to study factors as insight, motivation, and readiness to change for the better understanding the variables which are in probably connected with therapeutic effectiveness. AIM: The purpose of the study was to examine the state of readiness to change at the beginning and the end of inpatient short (six weeks) and long (12 weeks) therapeutic program in the Slovak Republic, Poland, and the Czech Republic, and look for the relationship between readiness to change, insight, and motivation in alcohol-dependent persons...
May 19, 2018: Neuro Endocrinology Letters
Raymond Barnhill, Peter Vermeulen, Sofie Daelemans, Pieter-Jan van Dam, Sergio Roman-Roman, Vincent Servois, Ilse Hurbain, Sophie Gardrat, Graça Raposa, Nicolas André, Rémi Dendale, Gaëlle Pierron, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani, Claire Lugassy
Up to 50% of uveal melanomas (UM) metastasize to the liver within 10 years of diagnosis, and these almost always prove rapidly fatal. Since histopathological growth patterns (HGP) of liver metastases of the replacement and desmoplastic type, particularly from colon and breast carcinoma, may import valuable biological and prognostic information, we have studied HGP in a series of 41 UM liver metastases originating from 41 patients from the period 2006-2017. Twenty patients underwent enucleation while 21 had radiation therapy...
June 19, 2018: Journal of Pathology. Clinical Research
Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Dichapong Kanjanawasee, Likhit Khattiyawittayakun, Kornkiat Snidvongs
BACKGROUND: A combination of H1 antihistamine (AH) with intranasal corticosteroid (INCS) is commonly prescribed to patients with allergic rhinitis (AR) who have an inadequate response to monotherapy. In this systematic review we aimed to determine the effects of AH combined with INCS (AH-INCS) for treating AR. METHODS: Literature searches were performed using Medline and Embase. Randomized, controlled trials that studied the effects of AH-INCS vs INCS monotherapy for treating patients with AR were included...
June 19, 2018: International Forum of Allergy & Rhinology
Kwok-Chiu Chang, Eric Nuermberger, Giovanni Sotgiu, Chi-Chiu Leung
Since standardized rifampin-based first-line regimens and fluoroquinolone-based second-line regimens were used to treat tuberculosis (TB), unfortunately without timely modification according to the drug resistance profile, TB and drug-resistant disease are still important public health threats worldwide. Although the last decade has witnessed advances in rapid diagnostic tools and use of repurposed and novel drugs for better managing drug-resistant TB, we need an appropriate TB control strategy and a well-functioning health infrastructure to ensure optimal operational use of rapid tests, judicious use of effective treatment regimens that can be rapidly tailored according to the drug resistance profile and timely management of risk factors and co-morbidities that promote infection and its progression to disease...
June 19, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Daniel L Rolnik, Fabricio da Silva Costa, Daljit Sahota, Jon Hyett, Andrew McLennan
AIM: To assess the quality of mean uterine artery pulsatility index (UtAPI) measurement in a first trimester pre-eclampsia screening program. METHODS: Consecutive patients attending first trimester screening for fetal chromosomal abnormalities also had combined screening for pre-eclampsia based on the Fetal Medicine Foundation (FMF) algorithm, in a large practice in Sydney, Australia, from May 2014 to February 2017. Distributions of mean UtAPI multiples of the median (MoM) on the logarithmic scale were plotted in relation to the normal median with 95% confidence interval (CI) for each operator and for each month...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
Kayla N Anderson, Martha A Rueter, Jennifer J Connor, Ascan F Koerner
Growing use of in vitro fertilization (IVF) has resulted in an elevated twin birth rate, and a burgeoning population of IVF twins who are now aging into adolescence and beyond. This study tests a model examining whether parental conformity expectations have differential effects on twins' versus singletons' parent-adolescent relationship satisfaction, and if this effect is indirectly associated with relative changes in twins' and singletons' internalizing and externalizing behavior from middle childhood to adolescence...
June 19, 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
Manfred Karras, Michał Dąbrowski, Radek Pohl, Jiří Rybáček, Jaroslav Vacek, Lucie Bednárová, Karol Grela, Ivo Starý, Irena G Stará, Bernd Schmidt
Helical chirality is a novel enantioselectivity inducing element in transition metal catalyzed transformations. The principle is illustrated herein for the example of asymmetric olefin metathesis. We describe the synthesis of the first helically chiral Ru-NHC alkylidene complex from an aminohelicene-derived imidazolium salt, which was ligated to the first generation Hoveyda-Grubbs catalyst. Kinetic data were aquired for benchmark test reactions and compared to an achiral catalyst. The helically chiral Ru-catalyst was evaluated in asymmetric RCM and ROM/CM reactions, which proceeded with promising levels of enantioselectivity...
June 19, 2018: Chemistry: a European Journal
Ashish Dhir
Curcumin, a principal curcuminoid present in turmeric, has an antioxidant, anti-inflammatory and neuroprotective properties. Preclinical studies have indicated its beneficial effect for the treatment of epilepsy disorders. The molecule has an anti-seizure potential in preclinical studies, including chemical and electrical models of acute and chronic epilepsy. Curcumin also possesses an anti-epileptogenic activity as it reduces spontaneous recurrent seizures severity in a kainate model of temporal lobe epilepsy...
June 19, 2018: Phytotherapy Research: PTR
Naglaa A Mostafa, Magda Assaf, Sami Elhakim, Mona R E Abdel-Halim, Eman El-Nabarawy, Khaled Ghareeb
BACKGROUND: The distinction of trichoepithelioma from basal cell carcinoma in small superficial biopsies is important but often challenging. This has inspired many scientists to test the validity of immunohistochemical markers in the differential diagnosis. OBJECTIVES: to develop an immunohistochemical protocol that helps in differentiation between both TE and BCC with higher sensitivity and specificity. METHODS: Using standard immunohistochemical techniques, we examined 10 TEs and 19 BCCs for the expression of CK19, Ki67, Androgen receptors (AR), CD10, and PHLDA1...
June 19, 2018: Journal of Cutaneous Pathology
Rupak Desai, Sandeep Singh, Maryam Baikpour, Hemant Goyal, Abhijeet Dhoble, Abhishek Deshmukh, Gautam Kumar, Rajesh Sachdeva
BACKGROUND: It is well known that obesity can lead to increased oxidative stress, which is one of the proposed mechanisms in the etiopathogenesis of Takotsubo Cardiomyopathy (TCM). However, it is unknown if the presence of obesity affects the outcomes in patients with TCM. METHODS: We queried the National Inpatient Sample database from 2010-2014 to identify adult patients who admitted with a principal diagnosis of TCM with and without obesity. We compared the categorical and continuous variables by Pearson's chi-square and Student's t-test respectively in propensity-score matched cohorts...
June 19, 2018: Clinical Cardiology
A Perutelli, C Tascini, L Domenici, S Garibaldi, C Baroni, E Cecchi, M G Salerno
OBJECTIVE: Tigecycline is a glycylcycline antimicrobial structurally related to minocycline, with a wide spectrum of activity that includes anaerobes and typical and atypical microorganisms causing pelvic inflammatory disease (PID). This study aimed to evaluate efficacy and safety of tigecycline in complicated PID and un-complicated PID after the failure of first-line antibiotic therapy. PATIENTS AND METHODS: Between May 2014 and April 2016 at the 2nd Unit of Obstetrics and Gynecology, Santa Chiara Hospital of Pisa a pilot study on 20 women with mild/moderate PID after the failure of first-line antibiotic therapy and on 8 women with complicated PID was conducted...
June 2018: European Review for Medical and Pharmacological Sciences
H-B Zheng, Y-T Fu, G Wang, L-H Sun, Y-Y Fan, T-W Yang
OBJECTIVE: We aimed to explore the effect of hyperphosphorylation of Tau on cognitive function of propofol-anesthetized rats. MATERIALS AND METHODS: Thirty 2-month-old male Wistar rats weighing 180-220 g were randomly divided into 3 groups (n=10): group of treating with saline (C group), group of treating with propofol for 1 hour (P1) and 24 h (P24 group). The cognitive function of rats was tested by Morris water maze before and 1 h or 24 h after drug administration...
June 2018: European Review for Medical and Pharmacological Sciences
X-L Yi, J-T Wang, C-Q Chu, Y-X Li, J-H Yin, S-L Liu
OBJECTIVE: To explore the cardiocerebral protective effect of dexmedetomidine as an anesthetic in colorectal cancer surgery. PATIENTS AND METHODS: A total of 246 colorectal cancer patients were enrolled in this retrospective analysis. Those patients were admitted to the Affiliated Hospital of Qingdao University and underwent surgery from July 2014 to July 2016. The patients were divided into observation group and control group according to the anesthetic used in surgery...
June 2018: European Review for Medical and Pharmacological Sciences
F Tonioni, M Mazza, G Autullo, G R Pellicano, P Aceto, V Catalano, G Marano, S Corvino, D Martinelli, V Fiumana, L Janiri, C Lai
OBJECTIVE: The aim of the present study was to compare socio-emotional patterns, temperamental traits, and coping strategies, between a group of Internet addiction (IA) patients and a control group. PATIENTS AND METHODS: Twenty-five IA patients and twenty-six healthy matched subjects were tested on IA, temperament, coping strategies, alexithymia and attachment dimensions. Participants reported their prevalent Internet use (online pornography, social networks, online games)...
June 2018: European Review for Medical and Pharmacological Sciences
M Stanisławska-Kubiak, E Mojs, R W Wójciak, B Piasecki, M Matecka, J Sokalski, P Kopczyński, P Fichna
OBJECTIVE: The aim of the study was to evaluate the cognitive functioning of children and youth with type 1 diabetes (T1DM). PATIENTS AND METHODS: The study included 68 children with type 1 diabetes, aged 6-17 years, divided into 3 groups according to the level of glycated hemoglobin (HbA1c): group 1: HbA1c ≤ 6.0-7.5%; group 2: HbA1c 7.6-8.5%; group 3: HbA1c over 8.6%. Wechsler's intelligence scale (WISC-R), the Trail of 10 words and Brickenkamp's and Zillmer's d2 Test of Attention were used to assess cognitive functioning...
June 2018: European Review for Medical and Pharmacological Sciences
M A Bakhrebah, M S Nassar, M S Alsuabeyl, W A Zaher, S A Meo
OBJECTIVE: Infectious diseases are one of the prime causes of death worldwide. An innovative sequence specific editing technology "Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)" has been tested on a broad range of microorganisms to target and destroy invading foreign DNA to human cells or tissues. This study aimed to discuss the mechanism and therapeutic usage of CRISPR/Cas9 genome editing technology in the management of various infectious disease pathogens...
June 2018: European Review for Medical and Pharmacological Sciences
M-G Lin, Y-K Hong, Y Zhang, B-B Lin, X-J He
OBJECTIVE: To evaluate the lncRNA DUXAP8 expression in bladder cancer and its mechanism. PATIENTS AND METHODS: Clinical specimens were analyzed. The expression of lncRNA in bladder cancer and adjacent tissues was detected using qRT-PCR. The χ2-test analysis was used to analyze the relationship between lncRNA DUXAP8 expression and clinicopathological information in patients with bladder cancer. The tumor cell activity and cell proliferation were measured by cell counting kit-8 (CCK8) and colony formation assay...
June 2018: European Review for Medical and Pharmacological Sciences
Y Wang, L-J Li, M-X Qiu, B-S Gong
OBJECTIVE: Bladder cancer is one of the most common malignant tumors of the urinary system characterized by a high recurrence rate after treatment. Paclitaxel is a new type of anti-neoplastic agent used for treatment by inhibiting the proliferation of bladder cancer cells. This study aimed to explore the mechanism of paclitaxel on the inhibition of bladder cancer cell proliferation by applying paclitaxel combined with miR-448 on bladder cancer cells. MATERIALS AND METHODS: Bladder cancer EJ cells were divided into 5 groups, including control group, paclitaxel group, negative control (NC) group, microRNA-448 (miR-448) mimic group, and paclitaxel combined with miR-448 mimic group...
June 2018: European Review for Medical and Pharmacological Sciences
H-H Zhang, A-H Li
OBJECTIVE: Long noncoding RNA FEZF1-AS1 (FEZF1-AS1) has been showed to involve in a variety of cancers. However, its function and clinical significance in cervical cancer (CC) have not been investigated. The aim of this study was to explore the prognostic value of FEZF1-AS1 in CC patients. PATIENTS AND METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to determine the expression level of FEZF1-AS1 in CC specimens and adjacent normal cervical tissues...
June 2018: European Review for Medical and Pharmacological Sciences
B Song, Y-J Tang, W-G Zhang, C-C Wan, Y Chen, L-J Zhang
OBJECTIVE: Extracellular signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway is widely involved in cell proliferation and invasion regulation. Enhanced expression or function of ERK1 is important for leukemia. Abnormal down-regulation of microRNA (miR)-143 is correlated with leukemia pathogenesis, indicating possible tumor-suppressing role. Bioinformatics analysis showed the existence of complementary binding sites between miR-143 and ERK1. This study aims to investigate whether the miR-143 plays a role in mediating ERK1 expression and proliferation and apoptosis of leukemia cells...
June 2018: European Review for Medical and Pharmacological Sciences
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