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https://www.readbyqxmd.com/read/29430408/using-bronchoscopy-to-detect-acquired-tracheoesophageal-fistula-in-mechanically-ventilated-patients
#1
Michael S Green, Johann J Mathew, Lia J Michos, Parmis Green, Mansoor M Aman
Introduction: An acquired Tracheoesophageal fistula (TEF) is commonly caused by a malignancy or trauma, with pulmonary infection or aspiration being the presenting symptom. However, in the critical care setting the presentation can be subtle and may present with difficult ventilation. High endotracheal tube cuff pressures can lead to tracheal erosions and thus increasing the chances for developing a TEF. Prolonged intubation in the presence of other risk factors like poor general state of health, episodic hypotension, nasogastric tubes, and repeated intubations can increase the likelihood of developing an acquired TEF...
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29428407/subclinical-haemorrhage-in-non-functional-adenomas
#2
H Cebula, E Fasciglione, M D N Santin, J Todeschi, F Severac, F Proust, J-L Dietemann, B Goichot
AIM: The prevalence and risk factors of subclinical haemorrhage on non-functional adenomas (NFA) remain controversial. The primary aim of our study was to assess the incidence of subclinical haemorrhage (SH) and the secondary objectives were to evaluate the risk factors of SH and the impact of SH on pituitary function at diagnosis. PATIENTS AND METHODS: This retrospective transversal analysis included 95 patients between January 2012 and December 2014. The patients included in this series were all adults (>18 years of age), who presented a non-functional adenoma confirmed by an endocrinological evaluation and on dedicated MRI pituitary imaging...
February 7, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29426831/cardiovascular-risk-factors-and-subclinical-organ-damage-after-hematopoietic-stem-cell-transplantation-in-pediatric-age
#3
Bianca Borchert-Mörlins, Nima Memaran, Martin Sauer, Britta Maecker-Kolhoff, Karl-Walter Sykora, Ricarda Blöte, Elena Bauer, Bernhard M W Schmidt, Anette Melk, Rita Beier
Advances in allogeneic hematopoietic stem cell transplantation (HSCT) in malignant and non-malignant diseases result in more long-term survivors, in whom cardiovascular (CV) disease is one leading non-cancer cause of death. This study aimed to evaluate risk factors and subclinical CV organ damage in survivors after HSCT in pediatric age. We enrolled 64 children in a cross-sectional approach 3.3 ± 3.1 years after HSCT. Anthropometric data, laboratory values, office and 24-h ambulatory blood pressure monitoring (ABPM) were evaluated, showing a high prevalence of obesity, hypertension and dyslipidemia...
February 9, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29424302/the-role-of-5-ht1a-receptor-in-the-cancer-as-a-new-opportunity-in-medicinal-chemistry
#4
Angela Corvino, Ferdinando Fiorino, Beatrice Severino, Irene Saccone, Francesco Frecentese, Elisa Perissutti, Paola Di Vaio, Vincenzo Santagada, Giuseppe Caliendo, Elisa Magli
The 5-HT1A receptor is a pharmacologically well characterized serotonin receptor subtype and it has long been investigated because of its involvement in several physio-pathological mechanisms and treatment of neurological diseases like ansia and depression. Serotonin (5-HT) also shows many non-neural functions such as essential hypertension, embryogenesis, follicle maturation and behavior. Moreover it exerts a growth factor function on different types of non-tumoral cells, and it was also found to be related to oncogenes...
February 9, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29419916/consensus-opinion-on-diagnosis-and-management-of-thrombotic-microangiopathy-in-australia-and-new-zealand
#5
REVIEW
Lucy Fox, Solomon J Cohney, Joshua Y Kausman, Jake Shortt, Peter D Hughes, Erica M Wood, Nicole M Isbel, Theo de Malmanche, Anne Durkan, Pravin Hissaria, Piers Blombery, Thomas D Barbour
Thrombotic microangiopathy (TMA) arises in a variety of clinical circumstances with the potential to cause significant dysfunction of the kidneys, brain, gastrointestinal tract and heart. TMA should be considered in all patients with thrombocytopenia and anaemia, with an immediate request to the haematology laboratory to look for red cell fragments on a blood film. Whilst TMA of any aetiology generally demands prompt treatment, this is especially so in thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS), where organ failure may be precipitous, irreversible and fatal...
February 8, 2018: Nephrology
https://www.readbyqxmd.com/read/29417332/left-sided-colectomy-one-of-the-important-risk-factors-of-metachronous-colorectal-adenoma-after-colectomy-for-colon-cancer
#6
Gee Young Yun, Hee Seok Moon, In Sun Kwon, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
BACKGROUND: Patients with a history of colonic resection for cancer have an increased risk for the development of metachronous malignant lesions. However, there is a lack of data on the detection rates of premalignant lesions during colonoscopy surveillance in these patients, and the few existing studies have shown conflicting results. AIMS: To identify the risk factor of metachronous premalignant lesions after colon cancer surgery. METHODS: We retrospectively screened consecutive patients who had undergone colonic surgery to treat colon cancer at the Chungnam National University Hospital between September 2009 and April 2014...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29410175/everolimus-as-cancer-therapy-cardiotoxic-or-an-unexpected-antiatherogenic-agent-a-narrative-review
#7
REVIEW
Georgios Karvelas, Aikaterini Roumpi, Christoforos Komporozos, Konstantinos Syrigos
Everolimus (EVE) is now approved by many agencies for the treatment of variable neoplasms. The risk of adverse events with these agent is not adequately defined. The purpose of this review was to summarize the everolimus - induced cardiotoxic effects to patients that received the specific drug as an antineoplastic factor and evaluate any possible anti-atherogenic effects due to systemic use of the drug. PubMed was searched for articles until August 2017. Articles included an expanded-access clinical trial, as well as phase 2 or 3 clinical trials (most of them were randomized)...
February 2, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29409767/association-of-hyperglycemic-crisis-with-an-increased-risk-of-end-stage-renal-disease-a-nationwide-population-based-cohort-study
#8
Yuan Kao, I-Jung Feng, Chien-Chin Hsu, Jhi-Joung Wang, Hung-Jung Lin, Chien-Cheng Huang
BACKGROUND: A hyperglycemic crisis episode (HCE) is associated with poor management of diabetes, which is a risk factor for end-stage renal disease (ESRD); however, the association between an HCE and ESRD has not been clarified. We conducted a nationwide population-based cohort study with the purpose of delineating this issue. METHODS: We identified 9,208 diabetic patients with an HCE and an identical number of diabetic patients with matched age, sex, and index date without an HCE between 2000 and 2002...
February 1, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29407077/development-and-external-validation-of-a-post-discharge-bleeding-risk-score-in-patients-with-acute-coronary-syndrome-the-bleemacs-score
#9
Sergio Raposeiras-Roubín, Jonas Faxén, Andrés Íñiguez-Romo, Jose Paulo Simao Henriques, Fabrizio D'Ascenzo, Jorge Saucedo, Karolina Szummer, Tomas Jernberg, Stefan K James, José Ramón González Juanatey, Stephen B Wilton, Wouter J Kikkert, Iván Nuñez-Gil, Albert Ariza-Sole, Xiantao Song, Dimitrios Alexopoulos, Christoph Liebetrau, Tetsuma Kawaji, Claudio Moretti, Zenon Huczek, Shao-Ping Nie, Toshiharu Fujii, Luis Correia, Masa-Aki Kawashiri, Berenice Caneiro-Queija, Rafael Cobas-Paz, José María García Acuña, Danielle Southern, Emilio Alfonso, Belén Terol, Alberto Garay, Dongfeng Zhang, Yalei Chen, Ioanna Xanthopoulou, Neriman Osman, Helge Möllmann, Hiroki Shiomi, Francesca Giordana, Fiorenzo Gaita, Michal Kowara, Krzysztof Filipiak, Xiao Wang, Yan Yan, Jing-Yao Fan, Yuji Ikari, Takuya Nakahayshi, Kenji Sakata, Masakazu Yamagishi, Oliver Kalpak, Sasko Kedev, Daniel Rivera-Asenjo, Emad Abu-Assi
BACKGROUND: Accurate 1-year bleeding risk estimation after hospital discharge for acute coronary syndrome (ACS) may help clinicians guide the type and duration of antithrombotic therapy. Currently there are no predictive models for this purpose. The aim of this study was to derive and validate a simple clinical tool for bedside risk estimation of 1-year post-discharge serious bleeding in ACS patients. METHODS: The risk score was derived and internally validated in the BleeMACS (Bleeding complications in a Multicenter registry of patients discharged with diagnosis of Acute Coronary Syndrome) registry, an observational international registry involving 15,401 patients surviving admission for ACS and undergoing percutaneous coronary intervention (PCI) from 2003 to 2014, engaging 15 hospitals from 10 countries located in America, Europe and Asia...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29399335/progress-in-research-on-intracranial-multiple-dural-arteriovenous-fistulas
#10
Yunbao Guo, Jing Yu, Ying Zhao, Jinlu Yu
Intracranial multiple dural arteriovenous fistulas (MDAVFs) are rare lesions that are difficult to treat. The key factors involved in the development of MDAVFs remain unknown. At present, the majority of reports on intracranial MDAVFs are confined to case reports and small case series, and thus understanding of MDAVFs is limited. The current review assesses the available literature to date with the aim of reviewing the progress in research on intracranial MDAVFs. Intracranial MDAVFs may be divided into two types: Synchronous and metachronous...
January 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29397614/-analysis-of-clinical-characteristics-of-paraganglioma-in-42-patients
#11
L L Jiang, H H Wu, N Bu, J Q Zhang, L Q Zhou, X H Guo
Objective: To summarize the clinical characteristics of paraganglioma. Methods: A total of 215 pheochromocytoma/ paraganglioma cases in Peking University First Hospital between January 1996 and December 2014 were retrospectively analyzed. The patients were divided into two groups according to the tumor position: pheochromacytoma group (173 patients) and paraganglioma group (42 patients). Then the clinical characteristics between the groups were compared. Results: There were 42 paraganglioma cases in the study, accounting for 19...
January 23, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29394727/-a-case-report-of-inguinal-malignant-lymphoma-after-surgery-for-hepatocellular-carcinoma
#12
Yuki Ohzato, Masahiro Murakami, Junzo Shimizu, Chikato Koga, Daiki Marukawa, Yuta Yoshida, Akinobu Yasuyama, Tae Matsumura, Akihiro Takada, Chizu Kameda, Ryohei Kawabata, Masaki Hirota, Shingo Noura, Hideaki Miwa, Junichi Hasegawa
An 81-year-old woman was followed up for hepatitis C from 1994. Sheh ad a previous history of hypertension and appendicitis. In October 2014, the patient underwent subsegmentectomy(S8)and cholecystectomy for hepatocellular carcinoma (HCC)(T2N0M0, Stage II ). From December 2015, the patient had taken ledipasvir-sofosbuvir orally for hepatitis C virus (HCV). In January 2016, we confirmed HCV-RNA shade transformation. In September 2016, enhanced CT showed a mass in theright lower quadrant of her abdomen. Shehad a hard 3 cm mass in thesameplaceon physical exam...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394190/post-diagnostic-calcium-channel-blocker-use-and-breast-cancer-mortality-a-population-based-cohort-study
#13
John Busby, Ken Mills, Shu-Dong Zhang, Fabio Giuseppe Liberante, Chris Cardwell
BACKGROUND: There have long been concerns that calcium channel blockers (CCBs), widely used to treat hypertension, may contribute to malignant growth through the evasion of apoptosis and proliferation of cancer cells. Worryingly, a recent cohort study found breast cancer patients who used CCBs had higher death rates, but interpreting these results was difficult as they were based on all-cause mortality and medication use before cancer diagnosis. We used UK population-based data to more robustly investigate the association between CCB use and cancer-specific mortality...
February 1, 2018: Epidemiology
https://www.readbyqxmd.com/read/29394093/mitochondrial-hsp90-accumulation-promotes-vascular-remodeling-in-pulmonary-arterial-hypertension
#14
Olivier Boucherat, Thibaut Peterlini, Alice Bourgeois, Valérie Nadeau, Sandra Breuils-Bonnet, Stéphanie Boilet-Molez, François Potus, Jolyane Meloche, Sophie Chabot, Caroline Lambert, Eve Tremblay, Young Chan Chae, Dario C Altieri, Gopinath Sutendra, Evangelos D Michelakis, Roxane Paulin, Steeve Provencher, Sébastien Bonnet
RATIONALE: Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with a poor prognosis and limited therapeutic option. Although the mechanisms contributing to vascular remodeling in PAH are still unclear, several features, including hyper-proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs), have led to the emergence of the cancer-like concept. The molecular chaperone heat shock protein 90 (HSP90) is directly associated with malignant growth and proliferation under stress conditions...
February 2, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29386239/fulminant-nocardiosis-due-to-a-multidrug-resistant-isolate-in-a-12-year-old-immunocompetent-child
#15
Olivia Senard, Stéphane Blanot, Gregory Jouvion, Véronica Rodriguez-Nava, Olivier Lortholary, Olivier Join-Lambert, Julie Toubiana
Nocardiosis is a rare cause of infection that usually affects immunocompromised adult patients and might not be recognized by pediatricians. We report a fatal case of disseminated nocardiosis in a previously healthy child initially admitted for an abdominal mass with suspicion of a renal malignant tumor. The patient, originating from Mali without any medical history, displayed abdominal pain with progressive altered general status. Laboratory and imaging findings revealed lymphocytic meningitis and disseminated abscesses in the brain and the cerebellum and a large number of cystic lesions of the kidney...
January 31, 2018: Pediatrics
https://www.readbyqxmd.com/read/29381963/apatinib-concurrent-gemcitabine-for-controlling-malignant-ascites-in-advanced-pancreatic-cancer-patient-a-case-report
#16
Lijun Liang, Lei Wang, Panrong Zhu, Youyou Xia, Yun Qiao, Kaiyuan Hui, Chenxi Hu, Yan Ren, Xiaodong Jiang
RATIONALE: Malignant ascites (MA) is one of the poor prognostic factors for advanced pancreatic cancer and can bring about serious symptoms. The improvement of quality of life for patients is priority. However, there is no standard method for the treatment for pancreatic cancer-mediated MA. Apatinib is a novel and highly selective tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2. There are no reports of concurrent apatinib with gemcitabine in patients with pancreatic cancer-mediated MA...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29374313/-importance-of-virchow-robin-spaces
#17
REVIEW
W Reith, A Haußmann
Virchow-Robin spaces are perivascular fluid-filled cavities that surround perforating arteries and veins in the brain parenchyma. As a rule in healthy people they are approximately 5 mm in diameter. Typical localizations are brainstem ganglia, mesencephalon and the white matter of the brain. Morphological imaging characteristics of Virchow-Robin spaces are round or tubular, smoothly bordered areas which are hyperintense in T2-weighted sequences. Virchow-Robin spaces represent a physiological structure in normal brain parenchyma...
January 26, 2018: Der Radiologe
https://www.readbyqxmd.com/read/29372125/dilated-thoracic-esophagus-presenting-with-painful-progressive-persistent-dysphagia-and-leukocytosis-of-unknown-origin
#18
Kyawzaw Lin, Jamil Shah, Emmanuel Ofori, Vahe Shahnazarian, Madhavi Reddy
Esophageal cancer is the eighth-most common cause of cancer-related mortality worldwide. The most common presenting symptom in advanced distal esophageal cancer is the sensation of sticking food, but it may sometimes present with bleeding and related complications, or asymptomatic leukocytosis. We present the case of a 77-year-old afebrile man with chronic alcoholism and a dilated thoracic esophagus with painful, progressive, and persistent dysphagia and leukocytosis of unknown origin. A 77-year-old man with a past medical history of hypertension and colonic cancer status post right hemicolectomy (surveillance negative) presented to the emergency department with painful, progressive, persistent, and worsening dysphagia for the past three weeks...
November 16, 2017: Curēus
https://www.readbyqxmd.com/read/29372095/cardiovocal-syndrome-a-rare-cause-of-hoarseness-in-a-patient-with-a-history-of-pulmonary-tuberculosis
#19
Rakul Nambiar, Dae Dalus, Anjali Srikumar
Hoarseness is a common clinical condition with underlying causes which can vary from reversible and benign to life-threatening and malignant. Cardiovocal syndrome may cause hoarseness secondary to left recurrent laryngeal nerve palsy when the recurrent laryngeal nerve is mechanically affected due to enlarged cardiovascular structures. We report a 28-year-old male who presented to the Government Medical College, Thiruvananthapuram, India, in 2013 with hoarseness. He had undergone irregular treatment for pulmonary tuberculosis (TB) two years previously...
November 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29371913/evaluation-of-efficacy-and-safety-for-bevacizumab-in-treating-malignant-pleural-effusions-caused-by-lung-cancer-through-intrapleural-injection
#20
Sun Zongwen, Kong Song, Zhao Cong, Fu Tian, Zhang Yan
Some clinical investigations have assessed the efficacy and safety of bevacizumab combined with platinum anti-cancer drugs versus platinum drugs alone in treating malignant pleural effusion (MPE) caused by lung cancer through intrapleural injection. This report is a meta-analysis of independent research conclusions. Eleven controlled trials with 769 MPE patients were included in this report. Pooled odds ratios and standardized mean difference with 95% confidence intervals were estimated using the fixed or random effects model of meta-analysis...
December 26, 2017: Oncotarget
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