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CCL2 AND CANCER

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https://www.readbyqxmd.com/read/29463257/cerium-oxide-and-barium-sulfate-nanoparticle-inhalation-affects-gene-expression-in-alveolar-epithelial-cells-type-ii
#1
Daniela Schwotzer, Monika Niehof, Dirk Schaudien, Heiko Kock, Tanja Hansen, Clemens Dasenbrock, Otto Creutzenberg
BACKGROUND: Understanding the molecular mechanisms of nanomaterial interacting with cellular systems is important for appropriate risk assessment. The identification of early biomarkers for potential (sub-)chronic effects of nanoparticles provides a promising approach towards cost-intensive and animal consuming long-term studies. As part of a 90-day inhalation toxicity study with CeO2 NM-212 and BaSO4 NM-220 the present investigations on gene expression and immunohistochemistry should reveal details on underlying mechanisms of pulmonary effects...
February 20, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29458367/the-rs1024611-in-the-ccl2-gene-and-risk-of-gynecological-cancer-in-asians-a-meta-analysis
#2
Shuying He, Xiuzhen Zhang
BACKGROUND: The -2518A/G (rs1024611) polymorphism of the CCL2 (C-C motif chemokine ligand 2), also known as MCP-1 (monocyte chemotactic protein-1) gene, has been reported to be associated with increased gynecological cancer risk, but the results are conflicting. METHODS: In this analysis, 1089 cases and 1553 controls from six publications were used to investigate the association between CCL2-2518A/G (rs1024611) polymorphism and the risk of gynecological cancer with a meta-analytic approach...
February 20, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29455640/ccl2-ccl5-secreted-by-the-stroma-induce-il-6-pyk2-dependent-chemoresistance-in-ovarian-cancer
#3
Jennifer Pasquier, Marie Gosset, Caroline Geyl, Jessica Hoarau-Véchot, Audrey Chevrot, Marc Pocard, Massoud Mirshahi, Raphael Lis, Arash Rafii, Cyril Touboul
BACKGROUND: Minimal residual disease is the main issue of advanced ovarian cancer treatment. According to the literature and previous results, we hypothesized that Mesenchymal Stromal Cells (MSC) could support this minimal residual disease by protecting ovarian cancer cells (OCC) from chemotherapy. In vitro study confirmed that MSC could induce OCC chemoresistance without contact using transwell setting. Further experiments showed that this induced chemoresistance was dependent on IL-6 OCC stimulation...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29454702/c-c-motif-chemokine-ligand-2-induces-proliferation-and-prevents-lipopolysaccharide-induced-inflammatory-responses-in-bovine-mammary-epithelial-cells
#4
Changwon Yang, Whasun Lim, Hyocheol Bae, Fuller W Bazer, Gwonhwa Song
C-C motif chemokine ligand 2 (CCL2) is a small chemokine which belongs to the CC-type chemokine family, and has chemoattractant activity for recruitment of monocytes to sites of inflammation. Overexpressed CCL2 binding to its receptor C-C chemokine receptor 2 increases the risk of breast cancer in humans, but its effects on proliferation of bovine mammary epithelial cells is not known. Maintaining a high level of proliferative activity in bovine mammary epithelial cells during lactation is important for improving milk yield and can benefit the dairy industry economically...
February 14, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29434856/high-fat-diet-induced-adipokine-and-cytokine-alterations-promote-the-progression-of-prostate-cancer-in-vivo-and-in-vitro
#5
Meng-Bo Hu, Hua Xu, Wen-Hui Zhu, Pei-De Bai, Ji-Meng Hu, Tian Yang, Hao-Wen Jiang, Qiang Ding
High-fat diet (HFD) -induced obesity is associated with more aggressive and lethal prostate cancer (PCa) in males, although the exact underlying mechanisms remain unclear. In the present study, transgenic adenocarcinoma of mouse prostate (TRAMP) models fed on an HFD (40% fat) or a control diet (CD; 16% fat) were generated, and cancer differentiation, local invasion and metastasis were compared at 20, 24 and 28 weeks. Mouse sera from each group were collected, and adipokines and cytokines were measured using multiplex immunoassays...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29409972/inhibition-of-dipeptidyl-peptidase-iv-prevents-high-fat-diet-induced-liver-cancer-angiogenesis-by-downregulating-chemokine-ligand-2
#6
Chen-Jie Qin, Ling-Hao Zhao, Xu Zhou, Hui-Lu Zhang, Wen Wen, Liang Tang, Min Zeng, Ming-Da Wang, Gong-Bo Fu, Shuai Huang, Wei-Jian Huang, Yuan Yang, Zhi-Jun Bao, Wei-Ping Zhou, Hong-Yang Wang, He-Xin Yan
Obesity is a major risk factor for hepatocellular carcinoma (HCC) and is typically accompanied by higher levels of serum dipeptidyl peptidase 4 (DPP4). However, the role of DPP4 in obesity-promoted HCC is unclear. Here, we found that consumption of a high-fat diet (HFD) promoted HCC cell proliferation and metastasis and led to poor survival in a carcinogen-induced model of HCC in rats. Notably, genetic ablation of DPP4 or treatment with a DPP4 inhibitor (vildagliptin) prevented HFD-induced HCC. Moreover, HFD-induced DPP4 activity facilitated angiogenesis and cancer cell metastasis in vitro and in vivo, and vildagliptin prevented tumor progression by mediating the pro-angiogenic role of chemokine ligand 2 (CCL2)...
January 31, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29387231/long-non-coding-rna-hotair-up-regulates-chemokine-c-c-motif-ligand-2-and-promotes-proliferation-of-macrophages-and-myeloid-derived-suppressor-cells-in-hepatocellular-carcinoma-cell-lines
#7
Yasuyuki Fujisaka, Tomoaki Iwata, Keiichi Tamai, Mao Nakamura, Mai Mochizuki, Rie Shibuya, Kazunori Yamaguchi, Tooru Shimosegawa, Kennichi Satoh
Accumulating evidence demonstrated that Hox antisense intergenic RNA (HOTAIR) serves essential roles in the development and metastasis of several types of cancer. In hepatocellular carcinoma (HCC), high expression of HOTAIR is associated with poor prognosis, and HOTAIR regulates cell migration and proliferation. However, the downstream molecular targets of HOTAIR depend on the cancer cell types, and little is known about the precise molecular mechanisms of HOTAIR involved in cancer development. The present study investigated the role of HOTAIR in HCC cell lines...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29386061/dihydroisotanshinone-i-combined-with-radiation-inhibits-the-migration-ability-of-prostate-cancer-cells-through-dna-damage-and-ccl2-pathway
#8
I-Yun Lee, Yin-Yin Lin, Yao-Hsu Yang, Yu-Shin Lin, Chun-Liang Lin, Wei-Yu Lin, Yu-Ching Cheng, Li-Hsin Shu, Ching-Yuan Wu
BACKGROUND: Radiotherapy plays an important role in the treatment of prostate cancer. Despite that sophisticated techniques of radiotherapy and radiation combined with chemotherapy were applied to the patients, some tumors may recur. Therefore, the study investigated the effect of dihydroisotanshinone I (DT) and the combination treatment of 5 μM DT and 5Gy irradiation (IR) against the migration ability of prostate cancer cells. METHODS: DT and the combination treatment were studied for its biological activity against migration ability of prostate cancer cells with transwell migration assay...
January 31, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29381686/wnt5a-induces-castration-resistant-prostate-cancer-via-ccl2-and-tumour-infiltrating-macrophages
#9
Geun Taek Lee, Seok Joo Kwon, Jongmyung Kim, Young Suk Kwon, Nara Lee, Jeong Hee Hong, Christina Jamieson, Wun-Jae Kim, Isaac Yi Kim
BACKGROUND: Although the standard treatment for the patients with recurrent and metastatic prostate cancer (CaP) is androgen deprivation therapy, castration-resistant prostate cancer (CRPC) eventually emerges. Our previous report indicated that bone morphogenetic protein 6 (BMP6) induced CRPC via tumour-infiltrating macrophages. In a separate line of study, we have observed that the WNT5A/BMP6 loop in CaP bone metastasis mediates resistance to androgen deprivation in tissue culture. Simultaneously, we have reported that BMP6 induced castration resistance in CaP cells via tumour-infiltrating macrophages...
January 30, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29375123/the-chemokine-mcp-1-ccl2-in-the-host-interaction-with-cancer-a-foe-or-ally
#10
REVIEW
Teizo Yoshimura
Macrophages are one of the most abundant leukocyte populations infiltrating tumor tissues and can exhibit both tumoricidal and tumor-promoting activities. In 1989, we reported the purification of monocyte chemoattractant protein-1 (MCP-1) from culture supernatants of mitogen-activated peripheral blood mononuclear cells and tumor cells. MCP-1 is a potent monocyte-attracting chemokine, identical to the previously described lymphocyte-derived chemotactic factor or tumor-derived chemotactic factor, and greatly contributes to the recruitment of blood monocytes into sites of inflammatory responses and tumors...
January 29, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29372285/comparison-of-inflammatory-urine-markers-in-patients-with-interstitial-cystitis-and-overactive-bladder
#11
Akira Furuta, Tokunori Yamamoto, Yasuyuki Suzuki, Momokazu Gotoh, Shin Egawa, Naoki Yoshimura
INTRODUCTION AND HYPOTHESIS: Chronic inflammatory conditions seem to be a shared characteristic in patients with interstitial cystitis (IC) and overactive bladder (OAB). Thus, we measured 40 inflammatory urine markers in IC patients with or without Hunner's lesions (HIC and NHIC respectively) and OAB patients. METHODS: Urine was collected from consecutive HIC patients, NHIC patients, and age and gender-matched OAB patients with no history of IC, recurrent urinary tract infection or bladder cancer...
January 25, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29337566/cationic-polymeric-nanoparticle-delivering-ccr2-sirna-to-inflammatory-monocytes-for-tumor-microenvironment-modification-and-cancer-therapy
#12
Song Shen, Yue Zhang, Kai-Ge Chen, Ying-Li Luo, Jun Wang
Accumulating evidence has confirmed that malignant tumors have a complex microenvironment, which consists of a heterogeneous collection of tumor cells and other cell subsets (including the full gamut of immune cells). Tumor-associated macrophages (TAMs), derived from circulating Ly6Chi monocytes, constitute the most substantial fraction of tumor-infiltrating immune cells in nearly all cancer types and contribute to tumor progression, vascularization, metastasis, immunosuppression and therapeutic resistance...
January 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29301607/force-mediated-proinvasive-matrix-remodeling-driven-by-tumor-associated-mesenchymal-stem-like-cells-in-glioblastoma
#13
Eun-Jung Lim, Yongjoon Suh, Seungmo Kim, Seok-Gu Kang, Su-Jae Lee
In carcinoma, cancer-associated fibroblasts participate in force-mediated extracellular matrix (ECM) remodeling, consequently leading to invasion of cancer cells. Likewise, the ECM remodeling actively occurs in glioblastoma (GBM) and the consequent microenvironmental stiffness is strongly linked to migration behavior of GBM cells. However, in GBM the stromal cells responsible for force-mediated ECM remodeling remain unidentified. We show that tumor-associated mesenchymal stem-like cells (tMSLCs) provide a proinvasive matrix condition in GBM by force-mediated ECM remodeling...
January 5, 2018: BMB Reports
https://www.readbyqxmd.com/read/29295986/macrophages-orchestrate-breast-cancer-early-dissemination-and-metastasis
#14
Nina Linde, Maria Casanova-Acebes, Maria Soledad Sosa, Arthur Mortha, Adeeb Rahman, Eduardo Farias, Kathryn Harper, Ethan Tardio, Ivan Reyes Torres, Joan Jones, John Condeelis, Miriam Merad, Julio A Aguirre-Ghiso
Cancer cell dissemination during very early stages of breast cancer proceeds through poorly understood mechanisms. Here we show, in a mouse model of HER2+ breast cancer, that a previously described sub-population of early-evolved cancer cells requires macrophages for early dissemination. Depletion of macrophages specifically during pre-malignant stages reduces early dissemination and also results in reduced metastatic burden at end stages of cancer progression. Mechanistically, we show that, in pre-malignant lesions, CCL2 produced by cancer cells and myeloid cells attracts CD206+/Tie2+ macrophages and induces Wnt-1 upregulation that in turn downregulates E-cadherin junctions in the HER2+ early cancer cells...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29282807/blocking-of-cytokines-signalling-attenuates-evoked-and-spontaneous-neuropathic-pain-behaviours-in-the-paclitaxel-rat-model-of-chemotherapy-induced-neuropathy
#15
S Al-Mazidi, M Alotaibi, T Nedjadi, A Chaudhary, M Alzoghaibi, L Djouhri
BACKGROUND: Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a serious dose-limiting neurotoxic effect of cancer drug treatment. The underlying mechanism(s) of this debilitating condition, which lacks effective drug treatment, is incompletely understood. However, neural-immune interactions, involving increased expression and release of cytokines, are believed to be involved. Here, we examined, in the paclitaxel rat model of CIPNP, whether plasma levels of 24 cytokines/chemokines change after paclitaxel treatment, and whether blocking of signalling of some of those cytokines would reverse/attenuate behavioural signs of CIPNP...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29247827/sec-induced-activation-of-anxa7-gtpase-suppresses-prostate-cancer-metastasis
#16
ShuYan Liu, Xiao Li, ZhaoMin Lin, Le Su, Shan Yan, BaoXiang Zhao, JunYing Miao
Annexin A7 (ANXA7) is a suppressor of tumorigenesis and metastasis in prostate cancer. Activated ANXA7 GTPase promotes prostate cancer cell apoptosis. However, the role and underlying mechanism of ANXA7 GTPase in prostate cancer metastasis have not been established. RKIP is a metastatic suppressor and downregulated in prostate cancer metastases. The binding of RKIP and its target proteins could inhibit the activation of its interactive partners. However, the effect of RKIP on ANXA7 GTPase activation is not clear...
December 13, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29234825/bindarit-attenuates-pain-and-cancer-related-inflammation-by-influencing-myeloid-cells-in-a-model-of-bone-cancer
#17
Shenghou Liu, Hongwei Gao, Chunzheng Gao, Wenguang Liu, Deguo Xing
C-C motif chemokine ligand 2 (CCL2) is a small cytokine that functions in inflammation and cancer development. Bindarit, a CCL2 inhibitor, is a small anti-inflammatory molecule proven safe by phase II trials in type 2 diabetic nephropathy patients. As cancer-related inflammation is a cause of pain, we investigated whether Bindarit suppresses cancer-related inflammation and pain. We established a bone-cancer mouse model by inoculating cancer cells. After applying Bindarit, we preformed pain sensitivity tests and checked cancer development by X-ray...
December 12, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29207614/danshen-improves-survival-of-patients-with-advanced-lung-cancer-and-targeting-the-relationship-between-macrophages-and-lung-cancer-cells
#18
Ching-Yuan Wu, Jong-Yuh Cherng, Yao-Hsu Yang, Chun-Liang Lin, Feng-Che Kuan, Yin-Yin Lin, Yu-Shih Lin, Li-Hsin Shu, Yu-Ching Cheng, Hung Te Liu, Ming-Chu Lu, Jthau Lung, Pau-Chung Chen, Hui Kuan Lin, Kuan-Der Lee, Ying-Huang Tsai
In traditional Chinese medicine, Salvia miltiorrhiza Bunge (danshen) is widely used in the treatment of numerous cancers. However, its clinical effort and mechanism in the treatment of advanced lung cancer are unclear. In our study, the in vivo protective effort of danshen in patients with advanced lung cancer were validated using data from the National Health Insurance Research Database in Taiwan. We observed in vitro that dihydroisotanshinone I (DT), a bioactive compound in danshen, exerts anticancer effects through many pathways...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29191392/cold-atmospheric-plasma-cap-activates-angiogenesis-related-molecules-in-skin-keratinocytes-fibroblasts-and-endothelial-cells-and-improves-wound-angiogenesis-in-an-autocrine-and-paracrine-mode
#19
Stephanie Arndt, Petra Unger, Mark Berneburg, Anja-Katrin Bosserhoff, Sigrid Karrer
BACKGROUND: Cold atmospheric plasma (CAP) emerged as a novel therapeutic field with applications developed for bacterial sterilization, wound healing and cancer treatment. For clinical implementation it is important to know how CAP works and which molecular changes occur after the CAP treatment. Vascularization is an important step during wound healing, however, the effects of CAP on wound angiogenesis are not well examined so far. Furthermore, it has not been investigated, whether CAP primarily affects endothelial cells directly or via paracrine mechanisms to modulate the vasculature...
November 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29168083/analysis-of-the-cancer-genome-atlas-tcga-database-identifies-an-inverse-relationship-between-interleukin-13-receptor-%C3%AE-1-and-%C3%AE-2-gene-expression-and-poor-prognosis-and-drug-resistance-in-subjects-with-glioblastoma-multiforme
#20
Jing Han, Raj K Puri
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. A variety of targeted agents are being tested in the clinic including cancer vaccines, immunotoxins, antibodies and T cell immunotherapy for GBM. We have previously reported that IL-13 receptor subunits α1 and α2 of IL-13R complex are overexpressed in GBM. We are investigating the significance of IL-13Rα1 and α2 expression in GBM tumors. In order to elucidate a possible relationship between IL-13Rα1 and α2 expression with severity and prognoses of subjects with GBM, we analyzed gene expression (by microarray) and clinical data available at the public The Cancer Genome Atlas (TCGA) database (Currently known as Global Data Commons)...
November 22, 2017: Journal of Neuro-oncology
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