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https://www.readbyqxmd.com/read/29778782/acyclovir-lipid-nanocapsules-gel-for-oromucosal-delivery-a-preclinical-evidence-of-efficacy-in-the-chicken-pouch-membrane-model
#1
Darine Abozaid, Alyaa Ramadan, Heba Barakat, Nawal Khalafallah
The study aimed to develop a patient-friendly acyclovir gel with improved efficacy in viral mouth infections, in response to patients' need for an intraoral acyclovir product. Acyclovir was loaded in lipid nanocapsules in gel form, and formulae were evaluated for oromucosal delivery. Lipid nanocapsules were prepared by the phase inversion method. Formulae were optimized to achieve maximum acyclovir entrapment and minimum acyclovir precipitation. Colloidal properties, and pharmaceutical performance indicators were assessed...
May 17, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29777934/specific-stability-indicating-spectrofluorimetric-method-for-determination-of-ledipasvir-in-the-presence-of-its-confirmed-degradation-products-application-in-human-plasma
#2
Ramadan Ali, Adel A Marzouk, Reda A Abdelhameid, Mahmoud A Omar
A rapid and specific spectrofluorimetric method with higher sensitivity was developed for determination of ledipasvir (LDS) in tablets and human plasma. The proposed method relies on hydrogen bonding formations between the hydroxyl groups of polyoxyethylene 50 stearate and LDS, causing significant enhancement of its native fluorescence. The fluorescence intensity was measured at 430 nm after excitation at 340 nm. The fluorescence-concentration plot was rectilinear over the range 1-400 ng mL-1 with detection and quantification limits of 0...
May 16, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29775483/ldha-gene-is-associated-with-pigeon-survivability-during-racing-competitions
#3
Sherif Ramadan, Takeshi Miyake, Junichi Yamaura, Miho Inoue-Murayama
Pigeon racing is a popular sport worldwide. Pigeons are under continuous selection to improve speed, spatial orientation, and endurance during long flights. However, numerous genetic and non-genetic factors affect survivability and homing ability, making such traits difficult for breeders to control. Polymorphisms in the lactate dehydrogenase A gene (LDHA) likely affects pigeon racing and homing abilities, due to its role in physical and mental performance. Additionally, the adenylate cyclase activating polypeptide 1 gene (ADCYAP1) has been associated with physiological and behavioral shifts that occur during avian migration...
2018: PloS One
https://www.readbyqxmd.com/read/29754329/efficacy-and-safety-of-sofosbuvir-plus-daclatasvir-with-or-without-ribavirin-large-real-life-results-of-patients-with-chronic-hepatitis-c-genotype-4
#4
Adel Abdel-Moneim, Alaa Aboud, Mohamed Abdel-Gabaar, Mohamed I Zanaty, Mohamed Ramadan
BACKGROUND AND AIM: Clinical studies evaluating the efficacy of daclatasvir (DCV) for treatment of chronic hepatitis C virus (HCV) genotype 4 (GT4) infection are scarce. This study aims to evaluate the efficacy and safety of DCV plus sofosbuvir (SOF) with or without ribavirin (RBV) for treatment of Egyptian patients infected with HCV GT4. METHODS: Between April 2016 and March of 2017, a large cohort of 946 patients with chronic HCV GT4 was enrolled for completing the treatment...
May 12, 2018: Hepatology International
https://www.readbyqxmd.com/read/29749916/image-guidance-and-improved-accuracy-of-external-ventricular-drain-tip-position-particularly-in-patients-with-small-ventricles
#5
Anan Shtaya, Joy Roach, Ahmed-Ramadan Sadek, Benjamin Gaastra, Jonathan Hempenstall, Diederik Bulters
OBJECTIVE External ventricular drain (EVD) insertion is one of the most common emergency neurosurgical procedures. EVDs are traditionally inserted freehand (FH) in an emergency setting, but often result in suboptimal positioning. Image-guided surgery (IGS) is selectively used to assist placement. However, the accuracy and practicality of IGS use is yet to be reported. In this study, the authors set out to assess if IGS is practical and improves the accuracy of EVD placement. METHODS Case notes and images obtained in patients who underwent frontal EVD placement were retrospectively reviewed...
May 11, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29744326/right-sided-pseudotumor-sternocleidomastoid-with-left-clavicle-fracture
#6
Shilpa Prabhu, Amal Faisal Al Abdulla, Magdy Ramadan Abdulmaaboud
Here, we present a rare case of unilateral fibromatosis colli of the sternocleidomastoid in an infant with contralateral clavicle fracture after assisted vaginal delivery. We also try to reason that because of right sternocleidomastoid tension, the fracture in the right clavicle was avoided, and because of left-sided clavicle fracture, left sternocleidomastoid muscle did not form pseudotumor as there was release of tension in these muscle fibers after fracture.
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29743542/disruption-of-neonatal-cardiomyocyte-physiology-following-exposure-to-bisphenol-a
#7
Manelle Ramadan, Meredith Sherman, Rafael Jaimes, Ashika Chaluvadi, Luther Swift, Nikki Gillum Posnack
Bisphenol chemicals are commonly used in the manufacturing of polycarbonate plastics, polyvinyl chloride plastics, resins, and thermal printing applications. Humans are inadvertently exposed to bisphenols through contact with consumer products and/or medical devices. Recent reports have shown a link between bisphenol-a (BPA) exposure and adverse cardiovascular outcomes; although these studies have been limited to adult subjects and models. Since cardiac physiology differs significantly between the developing and adult heart, we aimed to assess the impact of BPA exposure on cardiac function, using a neonatal cardiomyocyte model...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743032/use-of-an-electronic-partograph-feasibility-and-acceptability-study-in-zanzibar-tanzania
#8
Lindsay Elizabeth Litwin, Christina Maly, Asma Ramadan Khamis, Cyndi Hiner, Jérémie Zoungrana, Khadija Mohamed, Mary Drake, Michael Machaku, Mustafa Njozi, Salhiya Ali Muhsin, Yusuph K Kulindwa, Patricia P Gomez
BACKGROUND: The ePartogram is a tablet-based application developed to improve care for women in labor by addressing documented challenges in partograph use. The application is designed to provide real-time decision support, improve data entry, and increase access to information for appropriate labor management. This study's primary objective was to evaluate the feasibility and acceptability of ePartogram use in resource-constrained clinical settings. METHODS: The ePartogram was introduced at three facilities in Zanzibar, Tanzania...
May 9, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29741758/excellent-real-world-outcomes-of-adults-with-burkitt-lymphoma-treated-with-codox-m-ivac-plus-or-minus-rituximab
#9
Katie Y Zhu, Kevin W Song, Joseph M Connors, Heather Leitch, Michael J Barnett, Khaled Ramadan, Graham W Slack, Yasser Abou Mourad, Donna L Forrest, Donna E Hogge, Stephen H Nantel, Sujaatha Narayanan, Thomas J Nevill, Maryse M Power, David S Sanford, Heather J Sutherland, Tracy Tucker, Cynthia L Toze, Laurie H Sehn, Raewyn Broady, Alina S Gerrie
Treatment of Burkitt lymphoma (BL) with intensive, multi-agent chemotherapy with aggressive central nervous system (CNS) prophylaxis results in high cure rates, although no regimen is standard of care. We examined population-based survival outcomes of adults with BL treated with a modified combination of cyclophosphamide, vincristine, doxorubicin, prednisone and systemic high-dose methotrexate (MTX) (CODOX-M) with IVAC (ifosfamide, mesna, etoposide, cytarabine and intrathecal MTX) (CODOX-M/IVAC) ± rituximab over a 15-year period in British Columbia...
May 9, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29741574/ramadan-exposure-in-utero-and-child-mortality-in-burkina-faso-analysis-of-a-population-based-cohort-including-41-025-children
#10
Anja Schoeps, Reyn van Ewijk, Gisela Kynast-Wolf, Eric Nebié, Pascal Zabré, Ali Sié, Sabine Gabrysch
Ramadan exposure in utero can be regarded as a natural experiment to study how nutritional conditions in utero influence susceptibility to disease later in life. We analyzed data from rural Burkina Faso on 41,025 children born between 1993 and 2012, of which 25,093 to Muslim mothers. Ramadan exposure was assigned based on overlap between Ramadan dates and gestation, creating seven exclusive categories. We used proportional hazards regression with difference-in-differences to estimate the association between Ramadan exposure at different gestational ages and under-five mortality...
May 5, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29741567/a-matter-of-survival-the-detrimental-consequences-of-adverse-early-life-conditions
#11
Susanne R de Rooij
Studies across different species have shown that moderate dietary restriction is associated with longer lifespan. Surprisingly however, when diet is restricted in prenatal life, the effect is completely the opposite. Animal work and human epidemiologic data have shown that undernutrition in utero negatively affects health in later life and reduces lifespan considerably. In this issue of the American Journal of Epidemiology, Schoeps et al. provide new evidence that variations in nutritional conditions during pregnancy relate to the future health of the unborn child (1)...
May 5, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29741561/ramadan-pregnancy-nutrition-and-epidemiology
#12
Aryeh D Stein
Ramadan is observed by 1.6 billion Muslims. In a paper published this month that uses data from the Nouna Health and Demographic Surveillance System site in Burkina Faso, it is found that experiencing Ramadan in early pregnancy is associated with an increased risk of child mortality. Ramadan exposes observant individuals to a specific pattern of nutrition and other behaviors, including changes in sleep patterns. How these behaviors might result in child mortality is not yet understood, and the findings reported in the paper should be replicated in other settings...
May 5, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29739353/changes-in-serum-prolactin-level-during-intracytoplasmic-sperm-injection-and-effect-on-clinical-pregnancy-rate-a-prospective-observational-study
#13
Ahmed Kamel, Ayman A Halim, Mohamed Shehata, Salwa AlFarra, Yahia El-Faissal, Wafaa Ramadan, Ahmed M Hussein
BACKGROUND: Transient hyperprolactinemia was proven to adversely affect the outcome of IVF. We aimed to identify changes in serum prolactin levels in patients undergoing ICSI, and to evaluate the effect of these changes on the clinical pregnancy rate. METHODS: A prospective observational study included 90 patients scheduled for ICSI cycles. In each case 4 serum samples were collected during the cycle (midluteal, before ovum pick up procedure (OPU), 2 h after OPU, and before embryo transfer)...
May 9, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29738702/mesalazine-an-osteopontin-inhibitor-the-potential-prophylactic-and-remedial-roles-in-induced-liver-fibrosis-in-rats
#14
A Ramadan, Nehal Afifi, Nemat Z Yassin, Rehab F Abdel-Rahman, Sahar S Abd El-Rahman, Hany M Fayed
Liver fibrosis is a major health issue leading to high morbidity and mortality. The potential anti-fibrotic activity and the effect of mesalazine on osteopontin (OPN), an extra cellular matrix (ECM) component were evaluated in TAA-induced liver fibrosis in rats. For this purpose, forty-two adult male Wistar rats were divided into six groups. All animals, except the normal control, were intraperitoneally injected with TAA (200 mg/kg) twice per week for 6 weeks. In the hepato-protective study, animals were administered mesalazine (50 and 100 mg/kg, orally) for 4 weeks before induction of liver fibrosis then concomitantly with TAA injection...
May 5, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29738008/does-fasting-in-ramadan-increase-the-risk-of-developing-urinary-stones
#15
Abdullah O Al Mahayni, Sultan S Alkhateeb, Ibrahim H Abusaq, Abdullah A Al Mufarrih, Muath I Jaafari, Amen A Bawazir
OBJECTIVES: To explore the frequency of renal colic (RC) secondary to urinary stones in Ramadan compared to other months and seasons of the year. METHODS: Retrospective cross-sectional study using medical records of 237 patients admitted through the emergency room (ER) with a diagnosis of RC secondary to urinary stones over a 10-year period at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia. RESULTS: Patients fasting in Ramadan are 2 times more likely to present with a calculus of ureter as opposed to calculus in another location in the urinary tract, particularly when the holy month of Ramadan falls in the summer season...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29737552/competing-endogenous-rna-network-crosstalk-reveals-novel-molecular-markers-in-colorectal-cancer
#16
Nehal Samir, Marwa Matboli, Hanaa El-Tayeb, Ahmed El-Tawdi, Mohmed K Hassan, Sherif El-Khamisy, Hesham A E El-Akkad, Mohamed G Ramadan, Tarek N Al-Belkini, Farid El-Asmar
The competing endogenous RNA networks play a pivotal role in cancer diagnosis and progression. Novel properstrategies for early detection of colorectal cancer (CRC) are strongly needed. We investigated a novel CRC-specific RNA-based integrated competing endogenous network composed of lethal3 malignant brain tumor like1 (L3MBTL1) gene, long non-coding intergenic RNA- (lncRNA RP11-909B2.1) and homo sapiens microRNA-595 (hsa-miRNA-595) using in silico data analysis. RT-qPCR-based validation of the network was achieved in serum of 70 patients with CRC, 40 patients with benign colorectal neoplasm, and 20 healthy controls...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29730928/tuning-optoelectronic-properties-of-graphene-based-quantum-dots-c-16-x-si-x-h-10-family
#17
Fatima-Zahra Ramadan, Hala Ouarrad, Lalla Btissam Drissi
The electronic and optical properties of graphene-based quantum dots (QDs) are investigated using DFT and many body perturbation theory.. Formation energy, hardeness and electrophilicity show that all structures, from pyrene to silicene QD passing through 15 CSi QD configurations, are energetically and chemically stable. It is also found that they are reactive which implies their favorable character for the possible electronic transport and conductivity. The electronic and optical properties are very sensitive to the number and position of the substituted silicon-atoms as well as the directions of the light polarization...
May 6, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29729978/outcome-of-focused-pre-ramadan-education-on-metabolic-and-glycaemic-parameters-in-patients-with-type-2-diabetes-mellitus
#18
Lobna F El Toony, Dina Ali Hamad, Omar Mohammed Omar
BACKGROUND: Ramadan fasting is associated with the risk of acute complications including hypoglycaemia. Therefore, patients' education before Ramadan and follow up during Ramadan is essential for safe fasting. OBJECTIVES: To evaluate the effect of pre-Ramadan education program on biochemical parameters and the risk of hypoglycaemia in patients with type 2 diabetes mellitus. METHODS: A prospective interventional controlled design was carried out on 320 Muslim patients with type 2 diabetes...
April 25, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29728013/coronary-and-peripheral-vasomotor-responses-to-mental-stress
#19
Muhammad Hammadah, Jeong Hwan Kim, Ibhar Al Mheid, Ayman Samman Tahhan, Kobina Wilmot, Ronnie Ramadan, Ayman Alkhoder, Mohamed Khayata, Girum Mekonnen, Oleksiy Levantsevych, Yasir Bouchi, Belal Kaseer, Fahad Choudhary, Mohamad M Gafeer, Frank E Corrigan, Amit J Shah, Laura Ward, Michael Kutner, J Douglas Bremner, David S Sheps, Paolo Raggi, Viola Vaccarino, Habib Samady, Kreton Mavromatis, Arshed A Quyyumi
BACKGROUND: Coronary microvascular dysfunction may contribute to myocardial ischemia during mental stress (MS). However, the role of coronary epicardial and microvascular function in regulating coronary blood flow (CBF) responses during MS remains understudied. We hypothesized that coronary vasomotion during MS is dependent on the coronary microvascular endothelial function and will be reflected in the peripheral microvascular circulation. METHODS AND RESULTS: In 38 patients aged 59±8 years undergoing coronary angiography, endothelium-dependent and endothelium-independent coronary epicardial and microvascular responses were measured using intracoronary acetylcholine and nitroprusside, respectively, and after MS induced by mental arithmetic testing...
May 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29728012/increase-in-ischemic-stroke-incident-hospitalizations-among-bedouin-arabs-during-ramadan-month
#20
Noa Zimhony, Ibrahim Abu-Salameh, Iftach Sagy, Yotam Dizitzer, Liat Oxman, Maayan Yitshak-Sade, Victor Novack, Anat Horev, Gal Ifergane
BACKGROUND: Previous studies have not shown any significant effect on stroke incidence during Ramadan. We aimed to investigate the association between ischemic stroke incident hospitalizations and Ramadan, accounting for seasonality and temperature. METHODS AND RESULTS: This retrospective cohort study included all patients admitted with acute ischemic stroke to Soroka University Medical Center from June 2012 to June 2016. We obtained daily mean temperatures and relative humidity rates from 2 monitoring stations in South Israel...
May 3, 2018: Journal of the American Heart Association
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