Wellington de Almeida, Bruna Ferrary Deniz, Adriana Souza Dos Santos, Aline Martins Faustino, Osmar Vieira Ramires Junior, Felipe Schmitz, Ana Paula Muterle Varela, Thais Fumaco Teixeira, Patrícia Sesterheim, Fernanda Marques da Silva, Paulo Michel Roehe, Angela Ts Wyse, Lenir Orlandi Pereira
Zika virus (ZIKV) is a mosquito-borne flavivirus associated with several neurodevelopmental outcomes after in utero infection. Here, we studied a congenital ZIKV infection model with immunocompetent Wistar rats, able to predict disabilities and that could pave the way for proposing new effective therapies. We identified neurodevelopmental milestones disabilities in congenital ZIKV animals. Also, on 22nd postnatal day (PND), blood-brain barrier (BBB) proteins disturbances were detected in the hippocampus with immunocontent reduction of β_Catenin, Occludin and Conexin-43...
May 3, 2023: Brain, Behavior, and Immunity