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https://www.readbyqxmd.com/read/28325293/a-pirna-like-small-rna-induces-chemoresistance-to-cisplatin-based-therapy-by-inhibiting-apoptosis-in-lung-squamous-cell-carcinoma
#1
Yuyan Wang, Tyler Gable, Mark Z Ma, David Clark, Jun Zhao, Yi Zhang, Wei Liu, Li Mao, Yuping Mei
Lung cancer is the leading cause of cancer-related death worldwide. Although advanced drugs have benefitted patients, therapeutic success has largely been hampered because of rapid development of resistance. Here we report that PIWI-interacting RNA likes (piR-Ls), a novel type of functional sncRNAs, play key roles in chemoresistance to cisplatin (CDDP)-based chemotherapy in lung squamous cell carcinoma (LSCC). piR-L-138 was upregulated upon CDDP-based chemotherapy both in LSCC cells and in patient-derived xenograft (PDX) LSCC models...
March 17, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28323037/a-phosphorylation-wide-sncrna-screen-reveals-protein-functional-effector-sncrnas-pfernas-in-human-lung-somatic-cells
#2
Tyler Gable, Yuyan Wang, David Clark, Priti Kumari, Amol Carl Shetty, Li Mao, Yuping Mei
We recently reported that PIWI-interacting RNAs likes (piR-Ls) could regulate functions of the interacting phosphorylated proteins (p-Proteins). In addition, except for writers and erasers, functional efficacy of p-Proteins on their readers still remains unknown. We, therefore, reasoned there was a type of sncRNAs which could regulate functional efficacy of p-Proteins. Here, we profiled sncRNAs interacting with phosphorylated -Ser, -Thr and -Tyr residues in 3 HBE and 4 lung SCC cell lines, investigated effects and mechanisms of phosphorylated-residue-interacting sncRNAs...
March 16, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28321702/association-between-level-of-urinary-trace-heavy-metals-and-obesity-among-children-aged-6-19%C3%A2-years-nhanes-1999-2011
#3
Wentao Shao, Qian Liu, Xiaowei He, Hui Liu, Aihua Gu, Zhaoyan Jiang
Global prevalence of obesity has been increasing dramatically in all ages. Although traditional causes for obesity development have been studied widely, it is unclear whether environmental exposure of substances such as trace heavy metals affects obesity development among children and adolescents so far. Data from the National Health and Nutrition Examination Survey (1999-2011) were retrieved, and 6602 US children were analyzed in this study. Urinary level of nine trace heavy metals, including barium, cadmium, cobalt, cesium, molybdenum, lead, antimony, thallium, and tungsten, was analyzed for their association with the prevalence of obesity among children aged 6-19 years...
March 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28290193/molecularly-imprinted-plasmonic-substrates-for-specific-and-ultrasensitive-immunoassay-of-trace-glycoproteins-in-biological-samples
#4
Pir Muhammad, Xueying Tu, Jia Liu, Yijia Wang, Zhen Liu
Assays of glycoproteins hold significant biological importance and clinical values, for which immunoassay has been the workhorse tool. As immunoassays are associated with disadvantages such as poor availability of high-specificity antibodies, limited stability of biological reagents, and tedious procedure, innovative alternatives that can overcome these drawbacks are highly desirable. Plasmonic immunosandwich assay (PISA) has emerged as an appealing alternative to immunoassay for fast and sensitive determination of trace glycoproteins in biosamples...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28286721/functional-outcome-after-decompressive-craniectomy-in-patients-with-dominant-or-non-dominant-malignant-middle-cerebral-infarcts
#5
Bilal Kamal Alam, Ahmed S Bukhari, Salman Assad, Pir Muhammad Siddique, Haider Ghazanfar, Muhammad Junaid Niaz, Maryam Kundi, Saima Shah, Maimoona Siddiqui
BACKGROUND:  The use of decompressive craniectomy (DC) has been studied in the setting of different conditions, including traumatic brain injury, subarachnoid hemorrhage, and malignant middle cerebral artery (MCA) infarction. The rationale of this study is to determine the functional outcome after DC in patients with malignant MCA infarcts. METHODS:  A longitudinal cohort study was performed based on patients diagnosed with malignant MCA territory infarction admitted to the Neurosurgery Department of a tertiary care hospital in Islamabad, Pakistan between July 2015 and November 2016...
January 26, 2017: Curēus
https://www.readbyqxmd.com/read/28274063/intracoronal-radiolucency-in-an-unerupted-premolar-a-rare-occurrence
#6
Neil De Souza, Anna Vaz, Paul Chalakkal
Pre-eruptive Intracoronal Resorption (PIR) is a lesion that mostly occurs within the dentin in the occlusal part of the crown, next to the dentin-enamel junction. Such lesions are usually detected accidentally, on routine intraoral radiographs. This case report highlights a case of PIR detected in the mandibular second premolar of a 10 year old boy. The radiographic finding, size, position and restoration of the defect have been mentioned.
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28269460/monitoring-of-paces-and-gaits-using-binary-pir-sensors-with-rehabilitation-treadmill
#7
Jiang Lu, Ting Zhang, Qingquan Sun, Sanobar Kadiwal, Ishaq Unwala, Fei Hu
Recently, rehabilitation treadmills are designed for helping injured persons such as stroke patients and injury athletes in the process of physical therapy. By monitoring the changes of paces and gaits, one can estimate the progress of rehabilitation. At present, most devices that can estimate paces and gaits are wearable and/or expensive. This paper presents an inexpensive, non-intrusive wireless binary sensor system for pace estimation and lower-extreme gait recognition with low data throughput and high energy efficiency...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227710/monitoring-of-paces-and-gaits-using-binary-pir-sensors-with-rehabilitation-treadmill
#8
Jiang Lu, Ting Zhang, Qingquan Sun, Sanobar Kadiwal, Ishaq Unwala, Fei Hu, Jiang Lu, Ting Zhang, Qingquan Sun, Sanobar Kadiwal, Ishaq Unwala, Fei Hu, Ting Zhang, Ishaq Unwala, Qingquan Sun, Jiang Lu, Sanobar Kadiwal, Fei Hu
Recently, rehabilitation treadmills are designed for helping injured persons such as stroke patients and injury athletes in the process of physical therapy. By monitoring the changes of paces and gaits, one can estimate the progress of rehabilitation. At present, most devices that can estimate paces and gaits are wearable and/or expensive. This paper presents an inexpensive, non-intrusive wireless binary sensor system for pace estimation and lower-extreme gait recognition with low data throughput and high energy efficiency...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28197093/ultrastructural-and-functional-properties-of-a-giant-synapse-driving-the-piriform-cortex-to-mediodorsal-thalamus-projection
#9
Patric Pelzer, Heinz Horstmann, Thomas Kuner
Neocortico-thalamo-cortical loops represent a common, yet poorly understood, circuit employing giant synapses also referred to as "class I", giant, or driver synapses. Here, we characterize a giant synapse formed by projection neurons of the paleocortical piriform cortex (PIR) onto neurons of the mediodorsal thalamus (MD). Three-dimensional (3D) ultrastructure of labeled PIR-MD terminals, obtained by using serial-section scanning electron microscopy (EM) combined with photooxidation-based detection of labeled terminals, revealed a large terminal engulfing multiple postsynaptic dendritic excrescences...
2017: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/28193039/molecularly-imprinted-polymer-based-plasmonic-immunosandwich-assay-for-fast-and-ultrasensitive-determination-of-trace-glycoproteins-in-complex-samples
#10
Xueying Tu, Pir Muhammad, Jia Liu, Yanyan Ma, Shuangshou Wang, Danyang Yin, Zhen Liu
Glycoproteins play significant roles in many biological processes. Assays of glycoproteins have significant biological importance and clinical values, for which immunoassay has been the workhorse tool. However, immunoassay suffers from some disadvantages, such as poor availability of high-specificity antibodies and limited stability of biological reagents. Herein, we present an antibody-free and enzyme-free approach, called molecularly imprinted polymer (MIP)-based plasmonic immunosandwich assay (PISA), for fast and ultrasensitive detection of trace glycoproteins in complex samples...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28193002/organic-cyanide-decorated-sers-active-nanopipettes-for-quantitative-detection-of-hemeproteins-and-fe-3-in-single-cells
#11
Sumaira Hanif, Hailing Liu, Ming Chen, Pir Muhammad, Yue Zhou, Jiao Cao, Saud Asif Ahmed, Jingjuan Xu, Xinghua Xia, Hongyuan Chen, Kang Wang
It is challenging to develop a robust nanoprobe for real-time operational and accurate detection of heavy metals in single cells. Fe-CN coordination chemistry has been well studied to determine the structural characteristics of hemeproteins by different techniques. However, the frequently used cyanide ligands are inorganic molecules that release cyanide anion under particular conditions and cause cyanide poisoning. In the present study, organic cyanide (4-mercaptobenzonitrile, MBN) was utilized for the first time in developing a facile nanoprobe based on surface-enhanced Raman scattering (SERS) for quantitative detection of hemeproteins (oxy-Hb) and trivalent iron (Fe(3+)) ions...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28188942/photorefractive-keratectomy-with-mitomycin-c-for-high-myopia-three-year-follow-up-results
#12
Hassan Hashemi, Yahya Salimi, Poopak Pir, Soheila Asgari
Photorefractive keratectomy (PRK) is a safe and effective surgical keratorefractive technique which is done with the application of mitomycin-C (MMC) in cases of high myopia to prevent the formation of corneal haze This study was conducted to evaluate 3-year visual acuity and quality outcomes of PRK-MMC in high myopia. This before-after study was conducted on 20 individuals (40 eyes) with myopia more than 6.0 diopter (D). Visual acuity and quality indices were evaluated before and three years after the procedure and their stability was examined between the 1st and 3rd years...
January 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28169338/shrimp-ahpnd-causing-plasmids-encoding-the-pirab-toxins-as-mediated-by-pirab-tn903-are-prevalent-in-various-vibrio-species
#13
Jinzhou Xiao, Liyuan Liu, Yiyun Ke, Xiefei Li, Yunfei Liu, Yingjie Pan, Shuling Yan, Yongjie Wang
Acute hepatopancreatic necrosis disease (AHPND) is a newly emerging shrimp disease caused by pirAB toxins encoded by a plasmid found in Vibrio parahaemolyticus. The pirAB toxins are the homologs of the Photorhabdus insect-related (Pir) toxins. Here, we report the complete sequences of the AHPND-causing plasmid isolated from V. owensii, as well as those of its 11 siblings (pVH family). In addition, we also included 13 related plasmids (pVH-r family) without the pirAB genes isolated from a variety of species within the Vibrio Harveyi clade...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28165471/antibody-independent-mechanisms-regulate-the-establishment-of-chronic-plasmodium-infection
#14
Thibaut Brugat, Adam James Reid, Jing-Wen Lin, Deirdre Cunningham, Irene Tumwine, Garikai Kushinga, Sarah McLaughlin, Philip Spence, Ulrike Böhme, Mandy Sanders, Solomon Conteh, Ellen Bushell, Tom Metcalf, Oliver Billker, Patrick E Duffy, Chris Newbold, Matthew Berriman, Jean Langhorne
Malaria is caused by parasites of the genus Plasmodium. All human-infecting Plasmodium species can establish long-lasting chronic infections(1-5), creating an infectious reservoir to sustain transmission(1,6). It is widely accepted that the maintenance of chronic infection involves evasion of adaptive immunity by antigenic variation(7). However, genes involved in this process have been identified in only two of five human-infecting species: Plasmodium falciparum and Plasmodium knowlesi. Furthermore, little is understood about the early events in the establishment of chronic infection in these species...
February 6, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28153594/dose-dependent-effect-of-bisphenol-a-on-insulin-signaling-molecules-in-cardiac-muscle-of-adult-male-rat
#15
Preethi Sivashanmugam, Vigneswari Mullainadhan, Balasubramanian Karundevi
Environmental contaminant, Bisphenol-A (BPA) is a xenoestrogen, an essential component used for the production of two classes of polymers such as polycarbonate and epoxy resin which disrupts the normal endocrine function. BPA has intense effects on mice endocrine pancreas, an essential tissue involved in glucose metabolism. It disrupts pancreatic β-cell insulin content, induces hyperinsulinemia and insulin resistance in male rats. Cardiac muscle is an insulin responsive organ and insulin has direct effects on glucose transport...
March 25, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28152603/large-scale-and-targeted-quantitative-cross-linking-ms-using-isotope-labeled-protein-interaction-reporter-pir-cross-linkers
#16
Xuefei Zhong, Arti T Navare, Juan D Chavez, Jimmy K Eng, Devin K Schweppe, James E Bruce
Quantitative measurement of chemically cross-linked proteins is crucial to reveal dynamic information about protein structures and protein-protein interactions and how these are differentially regulated during stress, aging, drug treatment, and most perturbations. Previously, we demonstrated how quantitative in vivo cross-linking (CL) with stable isotope labeling of amino acids in cell culture (SILAC) enables both heritable and dynamic changes in cells to be visualized. In this work, we demonstrate the technical feasibility of proteome-scale quantitative in vivo CL-MS using isotope-labeled protein interaction reporter (PIR) cross-linkers and E...
February 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28150232/uniprot-protein-knowledgebase
#17
Sangya Pundir, Maria J Martin, Claire O'Donovan
The Universal Protein Resource (UniProt) is a freely available comprehensive resource for protein sequence and annotation data. UniProt is a collaboration between the European Bioinformatics Institute (EMBL-EBI), the Swiss Institute of Bioinformatics (SIB), and the Protein Information Resource (PIR). Across the three institutes more than 100 people are involved through different tasks such as expert curation, software development, and support.This chapter introduces the functionality and data provided by UniProt...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28135998/outcomes-of-a-care-coordinated-service-model-for-persons-with-severe-and-persistent-mental-illness-a-qualitative-study
#18
Anton N Isaacs, Keith Sutton, Kim Dalziel, Darryl Maybery
BACKGROUND: Owing to difficulties faced by individuals with severe and persistent mental illness (SPMI) in accessing multiple services, the Australian Government trialed a care coordinated service model called the Partners in Recovery (PIR) initiative. MATERIAL: A total of 45 stakeholders in Gippsland were asked what difference the initiative had made. DISCUSSION: The PIR initiative benefited not only clients and carers but also service providers...
February 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28133865/the-impact-of-the-chromium-supplementation-on-insulin-signalling-pathway-in-different-tissues-and-milk-yield-in-dairy-cows
#19
M Pantelić, L J Jovanović, R Prodanović, I Vujanac, M Đurić, T Ćulafić, S Vranješ-Đurić, G Korićanac, D Kirovski
Thirty days before expected time of parturition, 20 Holstein cows were divided into -Cr and +Cr groups. From day 25 before parturition (BP) up to day 30 after parturition (AP), +Cr cows received 10 mg of Cr (chromium-enriched yeast) daily. Muscle and adipose tissue samples were taken at days -30, -10, +7 and +10 related to parturition, when body condition score (BCS) was also determined. Hepatic tissue samples were taken at days -10 and +7. Tissue samples were used for determination of the insulin signalling pathway protein expressions...
January 30, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28122287/the-fluorescence-and-resonance-rayleigh-scattering-spectra-study-on-the-interactions-of-palladium-ii-nootropic-chelate-with-congo-red-and-their-analytical-applications
#20
Fang Chen, Jingdong Peng, Shaopu Liu, Huanjun Peng, Ziyu Pan, Lingli Bu, Huan Xiao, Ruiwen Zhang
A highly sensitive detection approach of resonance Rayleigh scattering spectra (RRS) is firstly applied to analyzing nootropic drugs including piracetam (PIR) and oxiracetam (OXI). In HCl-NaAc buffer solution (pH=3.0), the OXI chelated with palladium (II) to form the chelate cation [Pd2·OXI](2+), and then reacted with Congo red (CGR) by virtue of electrostatic attraction and hydrophobic force to form binary complex [Pd2·OXI]. CGR2, which could result in the great enhancement of RRS. The resonance Rayleigh scattering signal was recorded at λex=λem=375nm...
April 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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