keyword
MENU ▼
Read by QxMD icon Read
search

Pir

keyword
https://www.readbyqxmd.com/read/29458055/brain-activation-associated-to-olfactory-conditioned-same-sex-partner-preference-in-male-rats
#1
Genaro A Coria-Avila, Tamara Cibrian-Llanderal, Victor X Díaz-Estrada, Luis I García, Rebeca Toledo-Cárdenas, James G Pfaus, Jorge Manzo
Sexual preferences can be strongly modified by Pavlovian learning. For instance, olfactory conditioned same-sex partner preference can occur when a sexually naïve male cohabits with an scented male during repeated periods under the effects of enhanced D2-type activity. Preference is observed days later via social and sexual behaviors. Herein we explored brain activity related to learned same-sex preference (Fos-Immunoreactivity, IR) following exposure to a conditioned odor paired with same-sex preference. During conditioning trials males received either saline or the D2-type receptor agonist quinpirole (QNP) and cohabitated during 24 h with a stimulus male that bore almond scent on the back as conditioned stimulus...
February 16, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29453154/unique-pharmacology-of-a-novel-allosteric-agonist-sensitizer-insulin-receptor-monoclonal-antibody
#2
Simon A Hinke, Anne M Cieniewicz, Thomas Kirchner, Katharine D'Aquino, Rupesh Nanjunda, Jason Aligo, Robert Perkinson, Philip Cooper, Ken Boayke, Mark L Chiu, Steve Jarantow, Eilyn R Lacy, Yin Liang, Dana L Johnson, Jean M Whaley, Russell B Lingham, Anthony J Kihm
OBJECTIVE: Insulin resistance is a key feature of Type 2 Diabetes (T2D), and improving insulin sensitivity is important for disease management. Allosteric modulation of the insulin receptor (IR) with monoclonal antibodies (mAbs) can enhance insulin sensitivity and restore glycemic control in animal models of T2D. METHODS: A novel human mAb, IRAB-A, was identified by phage screening using competition binding and surface plasmon resonance assays with the IR extracellular domain...
February 3, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29431031/impact-of-cephalosporin-restriction-on-incidence-of-infections-with-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-in-an-endemic-setting
#3
Kristina Nadrah, Mateja Pirs, Samo Kreft, Manica Mueller Premru, Bojana Beovic
Decreasing cephalosporin use was described as an effective intervention in decreasing the incidence of infections caused by Klebsiella pneumoniae harbouring extended-spectrum beta-lactamase (ESBLKP). Due to sustained increased levels of infections caused by ESBLKP, a multifaceted antibiotic stewardship intervention aimed to decrease cephalosporin use was carried out at a large medical unit of a teaching hospital. All cephalosporins except the first-generation were restricted and could only be prescribed after authorization by an infectious disease physician...
February 12, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29407631/genetic-mutations-in-pear1-associated-with-cardiovascular-outcomes-in-chinese-patients-with-acute-coronary-syndrome
#4
Xiao-Yan Nie, Jun-Lei Li, Si-Bei Qin, Yu Fu, Guang-Kai Liang, Lu-Wen Shi, Hong Shao, Jian Liu, Yun Lu
OBJECTIVE: To investigate the association between PEAR1 (platelet endothelial aggregation receptor-1) polymorphisms and cardiovascular outcomes in acute coronary syndrome (ACS) in patients treated with aspirin and clopidogrel. METHODS: We genotyped eight common PEAR1 SNPs (rs2768759, rs12566888, rs12041331, rs11264579, rs2644592, rs822441, rs822442, and rs4661012), also CYP2C19*2 (rs4244285) and CYP2C19*3 (rs4986893) in 196 Chinese patients with ACS. We assessed the association between PEAR1 polymorphisms and platelet inhibition rate (PIR) measured by thromboelastography (TEG)...
February 1, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29399156/role-of-piwi-interacting-rna-651-in-the-carcinogenesis-of-non-small-cell-lung-cancer
#5
Shu-Jun Zhang, Jie Yao, Bao-Zhong Shen, Guang-Bo Li, Shan-Shan Kong, Dan-Dan Bi, Shang-Ha Pan, Bing-Lin Cheng
Piwi-interacting RNAs (piRNAs/piRs) are small non-coding RNAs that can serve important roles in genome stability by silencing transposable genetic elements. piR651, one of these novel piRNAs, regulates a number of biological functions, as well as carcinogenesis. Previous studies have reported that piR651 is overexpressed in human gastric cancer tissues and in several cancer cell lines, including non-small cell lung cancer (NSCLC) cell lines. However, the role of piRNAs in carcinogenesis has not been clearly defined...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29393725/effects-of-laparascopic-hernia-repair-by-pirs-percutan-internal-ring-suturing-technique-on-testicular-artery-blood-supply
#6
Akgun Oral, Leyla Karaca, Ali Ahiskalioglu, Abdullah Yildiz, Murat Yigiter, Mehmet Emin Celikkaya, Temirlan Chyndolotov, Ahmet Bedii Salman
PURPOSE: Percutaneous internal ring suturing technique (PIRS) is a minimally invasive technique in pediatric inguinal hernia repair. In the present study, a negative effect on testicular blood flow using PIRS technique has been investigated. METHODS: Forty male patients were included in the study prospectively. Two groups were formed as conventional open surgery (Group I) and PIRS technique (Group II). The resistive index (RI) value of the testicular artery was measured prospectively by using SMI (superb micro-vascular imaging) software with the color doppler ultrasound technique preoperatively and postoperatively at the first month...
February 2, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29383114/pir-b-inhibits-the-dc-function-and-disturbs-the-th17-treg-balance-in-lung-cancer-murine-model
#7
Huaxing Wu, Xiaoyu Zheng, Linlin Dong, Chunfeng Li, Mingyue Zhang, Guonian Wang, Kun Wang
Paired immunoglobulin-like receptor B (Pir-B) was an inhibitory receptor expressed on the surfaces of dendritic cells (DCs). Pir-B inhibit T helper (Th) 1 response and induce Th2 cell differentiation, leading to the imbalance of Th1/Th2 cells. However, the role and potential mechanism of Pir-B on the balance of Th17/regulatory T cells (Tregs) is still largely unknown in lung cancer murine model. In the present study, the DC function and Th17/Treg balance were destroyed during the progression of lung cancer and this was accompanied by an increased expression of Pir-B...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29382334/novel-evidence-for-a-piwi-interacting-rna-pirna-as-an-oncogenic-mediator-of-disease-progression-and-a-potential-prognostic-biomarker-in-colorectal-cancer
#8
Wenhao Weng, Na Liu, Yuji Toiyama, Masato Kusunoki, Takeshi Nagasaka, Toshiyoshi Fujiwara, Qing Wei, Huanlong Qin, Haifan Lin, Yanlei Ma, Ajay Goel
BACKGROUND: Emerging evidence suggests that PIWI-interacting RNAs (piRNAs) may be important epigenetic regulators of gene expression in human cancers; however, their functional and clinical significance in colorectal cancer (CRC) remains unknown. METHODS: We performed piRNA expression profiling in paired cancer and normal tissues through small RNA-sequencing. The clinical significance of candidate piRNAs was investigated, and independently validated in 771 CRC patients from three independent cohorts...
January 30, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29379608/trends-in-type-2-diabetes-detection-among-adults-in-the-usa-1999-2014
#9
Linda S Geiss, Kai McKeever Bullard, Ralph Brinks, Annika Hoyer, Edward W Gregg
Objective: To examine recent trends in type 2 diabetes detection among adults in the USA. Research design and methods: We used data from the 1999-2014 National Health and Nutrition Examination Surveys on non-pregnant adults (aged ≥18 years) not reporting a diagnosis of diabetes (n=16 644 participants, averaging about 2000 for each 2-year cycle). We defined undiagnosed diabetes as a fasting plasma glucose ≥126 mg/dL or a hemoglobin A1c ≥6.5% (48 mmol/mol)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29369157/hiv-reservoir-dynamics-in-haart-treated-poor-immunological-responder-patients-under-il-7-therapy
#10
Sandrine Logerot, Magali Rancez, Bénédicte Charmeteau-de Muylder, Suzanne Figueiredo-Morgado, Sandra Rozlan, Giuseppe Tambussi, Stéphanie Beq, Anne Couëdel-Courteille, Rémi Cheynier
OBJECTIVES: Recombinant Human IL-7 (rhIL-7) therapy allows reconstituting systemic and tissue-associated CD4 T-cell populations in HIV-infected poor immunological responder (PIR) patients. However, in vitro studies suggest that the impact of rhIL-7 treatment on HIV-DNA loads in vivo remains questionable. DESIGN: We assessed the dynamics of circulating HIV-DNA loads in IL-7-treated HIV-infected PIR individuals. METHODS: Forty-one rhIL-7-treated and 16 control participants from the INSPIRE-3 clinical trial were included...
January 23, 2018: AIDS
https://www.readbyqxmd.com/read/29367430/molecular-markers-increase-precision-of-the-european-association-of-urology-non-muscle-invasive-bladder-cancer-progression-risk-groups
#11
Kim E Van Kessel, Kirstin A van der Keur, Lars Dyrskjøt, Ferran Algaba, Naeromy Yc Welvaart, Willemien Beukers, Ulrika Segersten, Bastian Keck, Tobias Maurer, Tatjana Simic, Marcus Horstmann, Marc-Oliver Grimm, Gregers G Hermann, Karin Mogensen, Arndt Hartmann, Niels Harving, Astrid C Petersen, Jørgen B Jensen, Kerstin Junker, Joost L Boormans, Francisco X Real, Nuria Malats, Per-Uno Malmström, Torben F Ørntoft, Ellen C Zwarthoff
PURPOSE: The European Association of Urology (EAU) guidelines for non-muscle invasive bladder cancer (NMIBC) recommend risk stratification based on clinicopathological parameters. Our aim was to investigate the added value of biomarkers to improve risk stratification of NMIBC. EXPERIMENTAL DESIGN: We prospectively included 1239 patients in follow-up for NMIBC in six European countries. Fresh frozen tumor samples were analyzed for GATA2, TBX2, TBX3 and ZIC4 methylation and FGFR3, TERT, PIK3CA and RAS mutation status...
January 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29364188/passive-infrared-pir-based-indoor-position-tracking-for-smart-homes-using-accessibility-maps-and-a-star-algorithm
#12
Dan Yang, Bin Xu, Kaiyou Rao, Weihua Sheng
Indoor occupants' positions are significant for smart home service systems, which usually consist of robot service(s), appliance control and other intelligent applications. In this paper, an innovative localization method is proposed for tracking humans' position in indoor environments based on passive infrared (PIR) sensors using an accessibility map and an A-star algorithm, aiming at providing intelligent services. First the accessibility map reflecting the visiting habits of the occupants is established through the integral training with indoor environments and other prior knowledge...
January 24, 2018: Sensors
https://www.readbyqxmd.com/read/29339197/differential-insulin-and-steroidogenic-signaling-in-insulin-resistant-and-non-insulin-resistant-human-luteinized-granulosa-cells-a-study-in-pcos-patients
#13
Muskaan Belani, Abhilash Deo, Preeti Shah, Manish Banker, Pawan Singal, Sarita Gupta
Insulin resistance (IR) is one of the significant aberrations in polycystic ovarian syndrome (PCOS), however is only observed in 70%-80% of obese PCOS and 20%-25% of lean PCOS. Hyperinsulinemia accompanies PCOS-IR along with hyperandrogenemia against normal insulin and androgen levels in PCOS-non insulin resistance (NIR). This could possibly be due to defects in the downstream signaling pathways. The study thus aims to unravel insulin and steroidogenic signaling pathways in luteinized granulosa cells isolated from PCOS -IR and NIR vs matched controls...
January 12, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29337040/colonic-perforation-due-to-gi-histoplasmosis-in-an-immunocompetent-host-mimicking-crohn-s-disease
#14
Pir Saad, Hani Zamil, Marc F Catalano
No abstract text is available yet for this article.
January 11, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29311680/inhibition-of-insulin-resistance-by-pge1-via-autophagy-dependent-fgf21-pathway-in-diabetic-nephropathy
#15
Wei Wei, Xing-Rong An, Shi-Jie Jin, Xiao-Xue Li, Ming Xu
Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN). Alprostadil (Prostaglandin E1, PGE1) had protective effects on renal function. However, it is unknown whether PGE1 inhibited insulin resistance in renal tubule epithelial cells via autophagy, which plays a protective role in DN against insulin resistance. Insulin resistance was induced by palmitic acid (PA) in human HK-2 cells, shown as the decrease of insulin-stimulated AKT phosphorylation, glucose transporter-4 (GLUT4), glucose uptake and enhanced phosphorylation of insulin receptor substrate 1(IRS-1) at site serine 307 (pIRS-1ser307) and downregulated expression of IRS-1...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29302147/current-trends-of-drug-resistance-patterns-of-acinetobacter-baumannii-infection-in-blood-transfusion-dependent-thalassemia-patients
#16
Suhail Ahmed Almani, Ali Naseer, Sanjay Kumar Maheshwari, Pir Maroof, Raza Naseer, Haji Khan Khoharo
Objective: The present study aimed to evaluate the current trends of drug resistance patterns of Acinetobacter baumannii infection in blood transfusion-dependent thalassemia patients. Study Design: This study was a cross sectional study, conducted at the Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad, Sindh, Pakistan from October 2014 to January 2016. Subjects and Methods: Of 921 blood samples, A. baumannii strains were isolated from 100 blood samples...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29277694/comparative-transcriptomic-analysis-of-shrimp-hemocytes-in-response-to-acute-hepatopancreas-necrosis-disease-ahpnd-causing-vibrio-parahemolyticus-infection
#17
Zhihong Zheng, Fan Wang, Jude Juventus Aweya, Ruiwei Li, Defu Yao, Mingqi Zhong, Shengkang Li, Yueling Zhang
The recent emergence of acute hepatopancreas necrosis disease (AHPND) in shrimps has posed a major challenge in the shrimp aquaculture industry. The Pir toxin proteins carried by some strains of Vibrio parahaemolyticus are believed to play essential roles in the pathogenesis of AHPND. However, few studies have so far explored how the host immune system responds to these bacteria. In this study, AHPND V. parahaemolyticus (with Pir) and non-AHPND V. parahaemolyticus (without Pir) were injected into two groups of shrimps, and the hemocytes collected for comparative transcriptomic analyses...
December 22, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29240232/trends-in-self-reported-oral-health-of-us-adults-national-health-and-nutrition-examination-survey-1999-2014
#18
Kar Yan Li, Christopher E Okunseri, Colman McGrath, May C M Wong
OBJECTIVE: Single-item self-reported oral health (SROH) is a convenient and reliable measure for the assessment of population-based oral health. However, little is known about trends and its associations among US adults. This study investigated trends in SROH (aged 20+ years) and the associated factors among adults living in the United States. METHODS: Self-reported oral health data for 41 621 adults aged 20+ years from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2014 were analysed...
December 14, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29234187/efficacy-of-%C3%AE%C2%B5-poly-l-lysine-as-an-antibacterial-additive-for-platelets-stored-at-room-temperature
#19
Hosein Timori Naghadeh, Zohreh Sharifi, Saeideh Soleimani, Zainab Pir Mohamad Jamaat, Shirin Ferdowsi
No abstract text is available yet for this article.
September 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29227731/injuries-in-japanese-junior-soccer-players-during-games-and-practices
#20
Kenji Kuzuhara, Masashi Shibata, Ryo Uchida
CONTEXT:   Soccer is the most popular junior sport in the world. In junior sports, injury analysis and injury-prevention measures for players, especially those under 12 years of age, are urgently needed. OBJECTIVE:   To prospectively study the incidence, sites, types, and mechanisms of injuries in elementary school-aged junior soccer players during games and practices. DESIGN:   Descriptive epidemiology study. SETTING:   Elementary school-aged junior soccer teams in Nagoya, Japan...
December 11, 2017: Journal of Athletic Training
keyword
keyword
43321
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"