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https://www.readbyqxmd.com/read/29240232/trends-in-self-reported-oral-health-of-us-adults-national-health-and-nutrition-examination-survey-1999-2014
#1
Kar Yan Li, Christopher E Okunseri, Colman McGrath, May C M Wong
OBJECTIVE: Single-item self-reported oral health (SROH) is a convenient and reliable measure for the assessment of population-based oral health. However, little is known about trends and its associations among US adults. This study investigated trends in SROH (aged 20+ years) and the associated factors among adults living in the United States. METHODS: Self-reported oral health data for 41 621 adults aged 20+ years from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2014 were analysed...
December 14, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29234187/efficacy-of-%C3%AE%C2%B5-poly-l-lysine-as-an-antibacterial-additive-for-platelets-stored-at-room-temperature
#2
Hosein Timori Naghadeh, Zohreh Sharifi, Saeideh Soleimani, Zainab Pir Mohamad Jamaat, Shirin Ferdowsi
No abstract text is available yet for this article.
September 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29227731/injuries-in-japanese-junior-soccer-players-during-games-and-practices
#3
Kenji Kuzuhara, Masashi Shibata, Ryo Uchida
CONTEXT:   Soccer is the most popular junior sport in the world. In junior sports, injury analysis and injury-prevention measures for players, especially those under 12 years of age, are urgently needed. OBJECTIVE:   To prospectively study the incidence, sites, types, and mechanisms of injuries in elementary school-aged junior soccer players during games and practices. DESIGN:   Descriptive epidemiology study. SETTING:   Elementary school-aged junior soccer teams in Nagoya, Japan...
December 11, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29218568/peer-education-group-intervention-to-reduce-psychological-insulin-resistance-a-pilot-mixed-method-study-in-a-chinese-population
#4
Ka Yan Or, Benjamin Hoi-Kei Yip, Chi Hang Lau, Hing Han Chen, Yuk Wah Chan, Kam Pui Lee
INTRODUCTION: Psychological insulin resistance (PIR) is common among type II diabetes (DM) patients. Although interventions to reduce PIR have been suggested, there is no standardized intervention to reduce PIR. This trial aimed to assess the preliminary effectiveness of a well-structured interventional patient group (for sample size calculation for larger trials), as well as the acceptability and feasibility of this intervention group. METHODS: This study used a quasi-experimental, mixed-method approach...
December 7, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29209880/efficacy-of-locally-produced-latanoprost-in-the-control-of-intraocular-pressure-in-patients-with-primary-open-angle-glaucoma
#5
Pir Salim Mahar, Nadeem H Butt, Syed Imtiaz Ali
PURPOSE: To determine the efficacy of locally produced Latanoprost in reducing the intraocular pressure (IOP) in patients with Primary open-angle glaucoma (POAG). DESIGN: Open-label, non-comparative, observational case study with non-probability purposive sampling. METHODS: A total of 48 patients (94 eyes) of either gender were recruited from glaucoma clinic with the diagnosis of POAG, having IOP of more than 21 mmHg. Patients were commenced on locally produced Latanoprost (Vislat 0...
December 5, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29191965/caenorhabditis-elegans-models-of-tauopathy
#6
REVIEW
Ghulam Jeelani Pir, Bikash Choudhary, Eckhard Mandelkow
One of the hallmarks of the tauopathies, which include the neurodegenerative disorders, such as Alzheimer disease (AD), corticobasal degeneration, frontotemporal dementia, and progressive supranuclear palsy (PSP), is the abnormal accumulation of post-translationally modified, insoluble tau. The result is a loss of neurons, decreased mental function, and complete dependence of patients on others. Aggregation of tau, which under physiologic conditions is a highly soluble protein, is thought to be central to the pathogenesis of these diseases...
December 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29126479/fast-probing-of-glucose-and-fructose-in-plant-tissues-via-plasmonic-affinity-sandwich-assay-with-molecularly-imprinted-extraction-microprobes
#7
Pir Muhammad, Jia Liu, Rongrong Xing, Yanrong Wen, Yijia Wang, Zhen Liu
Determination of specific target compounds in agriculture food and natural plant products is essential for many purposes; however, it is often challenging due to the complexity of the sample matrices. Herein we present a new approach called plasmonic affinity sandwich assay for the facile and rapid probing of glucose and fructose in plant tissues. The approach mainly relies on molecularly imprinted plasmonic extraction microprobes, which were prepared on gold-coated acupuncture needles via boronate affinity controllable oriented surface imprinting with the target monosaccharide as the template molecules...
December 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29118270/upregulation-of-pir-gene-expression-induced-by-human-papillomavirus-e6-and-e7-in-epithelial-oral-and-cervical-cells
#8
Diego Carrillo, Juan P Muñoz, Hernán Huerta, Gabriel Leal, Alejandro Corvalán, Oscar León, Gloria M Calaf, Ulises Urzúa, Enrique Boccardo, Julio C Tapia, Francisco Aguayo
The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV E6 and E7 oncoproteins. Transcriptomic assay using DNA microarrays revealed that PIR gene expression was detected in oral cells in an HR-HPV E6/E7-dependent manner. In addition, PIR was overexpressed in HPV-positive SiHa and Ca Ski cells, whereas it was undetectable in HPV-negative C33A cells...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29113673/esophageal-adenocarcinoma-stage-iii-survival-based-on-pathological-response-to-neoadjuvant-treatment
#9
Katrin Schwameis, Joerg Zehetner, Jeffrey A Hagen, Daniel S Oh, Stephanie G Worrell, Kais Rona, Nathan Cheng, Jamil Samaan, Kyle M Green, John C Lipham
BACKGROUND: Neoadjuvant chemoradiotherapy is the standard treatment for locally advanced esophageal adenocarcinomas (EAC). Pathological response is thought to be a major prognostic factor. Aims of this study were to determine the frequency of complete response and to compare the survival of complete and incomplete responders in stage III EAC. METHODS: A retrospective review was performed of all stage III patients that underwent neoadjuvant therapy followed by esophagectomy between 1999 and 2015...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29101797/blocking-nocturnal-blue-light-for-insomnia-a-randomized-controlled-trial
#10
Ari Shechter, Elijah Wookhyun Kim, Marie-Pierre St-Onge, Andrew J Westwood
The use of light-emitting electronic devices before bedtime may contribute to or exacerbate sleep problems. Exposure to blue-wavelength light in particular from these devices may affect sleep by suppressing melatonin and causing neurophysiologic arousal. We aimed to determine if wearing amber-tinted blue light-blocking lenses before bedtime improves sleep in individuals with insomnia. Fourteen individuals (n = 8 females; age ± SD 46.6 ± 11.5 y) with insomnia symptoms wore blue light-blocking amber lenses or clear placebo lenses in lightweight wraparound frames for 2 h immediately preceding bedtime for 7 consecutive nights in a randomized crossover trial (4-wk washout)...
October 21, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29100535/construction-and-characterization-of-an-improved-dna-launched-infectious-clone-of-duck-hepatitis-a-virus-type-1
#11
Junhao Chen, Ruihua Zhang, Shaoli Lin, Pengfei Li, Jingjing Lan, Zhijing Xie, Yu Wang, Shijin Jiang
BACKGROUND: DNA-launched infectious system is a useful tool with high rescue efficiency that allows the introduction of mutations in specific positions to investigate the function of an individual viral element. Rescued virus particles could be harvested by directly transfecting the DNA-launched recombinant plasmid to the host cells, which will reduce labor and experimental cost by skipping the in vitro transcription assay. METHODS: A total of four overlapping fragments covering the entire viral genome were amplified and then were assembled into a transformation vector based on pIRES2-EGFP to establish the DNA-launched infectious system of duck hepatitis A virus type 1 (DHAV-1), named pIR-DHAV-1...
November 3, 2017: Virology Journal
https://www.readbyqxmd.com/read/29094444/metformin-as-a-prophylactic-treatment-of-gestational-diabetes-in-pregnant-patients-with-pregestational-insulin-resistance-a-randomized-study
#12
Enrique Valdés, Alvaro Sepúlveda-Martínez, Paula Candia, Nancy Abusada, Rodrigo Orellana, Bárbara Manukian, Eduardo Cuellar
AIM: We aimed to assess the use of metformin (MTF) in the prevention of gestational diabetes mellitus (GDM) in patients with pregestational insulin resistance (PIR). METHODS: A double blind, multicenter, randomized trial was carried out in patients with a history of PIR and pregestational MTF treatment. Groups were allocated either to MTF 1700 mg/day or placebo. Patients were recruited between 12(+0) and 15(+6)  gestational weeks, and treatment was extended until week 36...
November 2, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29067243/treating-psychological-insulin-resistance-in-type-2-diabetes
#13
Nancy A Allen, Sofija E Zagarins, Rebecca G Feinberg, Garry Welch
AIMS: The phenomenon of psychological insulin resistance (PIR) has been well documented for two decades, but interventions to treat PIR have not been well described. The aim of this study was to describe interventions used to treat psychological insulin resistance by certified diabetes educators (CDE's). METHODS: A secondary data analysis study using empirical data from a trial (N = 234) that included four CDEs providing counseling for psychological insulin resistance...
March 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29060346/coherence-analysis-of-invasive-blood-pressure-and-its-noninvasive-indicators-for-improvement-of-cuffless-measurement-accuracy
#14
Xiao-Rong Ding, Bryan P Yan, Yuan-Ting Zhang, Jing Liu, Peng Su, Ni Zhao
Cuffless technology for blood pressure (BP) measurement offers great potential for unobtrusive monitoring of hypertension. However, the accuracy is still a challenging issue probably owning to the inadequacy of existing noninvasive BP indicators in tracking BP changes, i.e., either the poor trackability of the indicators or the lack of relationship to map the indicators to BP. To figure out the covariation of BP-related noninvasive indicators and BP, we propose to analyze the coherence of intra-arterial systolic BP (SBP) and a selected group of noninvasive indicators, including the mostly used pulse transit time (PTT), photoplethysmogram intensity ratio (PIR) and RR interval (RRI) of electrocardiogram (ECG), in both time domain, with singular spectrum analysis (SSA), and frequency domain, with cross-spectral analysis...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29056325/pten-regulates-pi-3-4-p2-signaling-downstream-of-class-i-pi3k
#15
Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E Anderson, David Barneda, Pınar Pir, Hiroki Nakanishi, Satoshi Eguchi, Atsushi Koizumi, Junko Sasaki, Véronique Juvin, Vladimir Y Kiselev, Izabella Niewczas, Alexander Gray, Alexandre Valayer, Dominik Spensberger, Marine Imbert, Sergio Felisbino, Tomonori Habuchi, Soren Beinke, Sabina Cosulich, Nicolas Le Novère, Takehiko Sasaki, Jonathan Clark, Phillip T Hawkins, Len R Stephens
The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P3. PI(3,4,5)P3 can be dephosphorylated by 3- or 5-phosphatases, the latter producing PI(3,4)P2. The PTEN tumor suppressor is thought to function primarily as a PI(3,4,5)P3 3-phosphatase, limiting activation of this pathway. Here we show that PTEN also functions as a PI(3,4)P2 3-phosphatase, both in vitro and in vivo. PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated cells...
November 2, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29054162/a-chronological-framework-connecting-the-early-upper-palaeolithic-across-the-central-asian-piedmont
#16
Kathryn E Fitzsimmons, Radu Iovita, Tobias Sprafke, Michelle Glantz, Sahra Talamo, Katharine Horton, Tyler Beeton, Saya Alipova, Galymzhan Bekseitov, Yerbolat Ospanov, Jean-Marc Deom, Renato Sala, Zhaken Taimagambetov
Central Asia has delivered significant paleoanthropological discoveries in the past few years. New genetic data indicate that at least two archaic human species met and interbred with anatomically modern humans as they arrived into northern Central Asia. However, data are limited: known archaeological sites with lithic assemblages generally lack human fossils, and consequently identifying the archaeological signatures of different human groups, and the timing of their occupation, remains elusive. Reliable chronologic data from sites in the region, crucial to our understanding of the timing and duration of interactions between different human species, are rare...
December 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29040791/roles-of-mmu_pir_003399-in-microcystin-leucine-arginine-mc-lr-induced-reproductive-toxicity-in-the-spermatogonial-cells-and-testis
#17
Ling Zhang, Xiannan Meng, Zou Xiang, Dongmei Li, Xiaodong Han
Our previous work has demonstrated that microcystin-leucine arginine (MC-LR) is a potent toxin for the reproductive system of male mice and it exerts cytotoxicity in spermatogonial cells, resulting in the constitutional and functional changes of the mouse testis. The present study was designed to investigate the functions of P-element-induced wimpy (piwi)-interacting RNAs (piRNAs) in MC-LR-induced reproductive toxicity in male mice. We observed an increase in the mmu_piR_003399 level in spermatogonial cells and mouse testicular tissues following treatment with MC-LR...
October 12, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29039139/individualizing-the-tibial-tubercle-to-trochlear-groove-distance-to-patient-specific-anatomy-improves-sensitivity-for-recurrent-instability
#18
Mark J Heidenreich, Thomas L Sanders, Mario Hevesi, Nicholas R Johnson, Isabella T Wu, Christopher L Camp, Diane L Dahm, Aaron J Krych
PURPOSE: An initial episode of patellar instability poses a treatment challenge given the absence of a valid, reproducible, and universally applicable predictor of recurrence. Recently, a series of patellar instability ratios (PIRs) were described. Each ratio consisted of the traditional tibial tubercle to trochlear groove (TT-TG) distance normalized to patient-specific measures. The purpose of this study was to investigate the reliability and validity of these novel measures. METHODS: Eighty-seven patients experiencing a first-time lateral patellar dislocation were identified in a retrospective manner...
October 11, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29021976/learning-curves-for-laparoscopic-repair-of-inguinal-hernia-and-communicating-hydrocele-in-children
#19
Catarina Barroso, Péter Etlinger, Ana Luísa Alves, Angélica Osório, José Luís Carvalho, Ruben Lamas-Pinheiro, Jorge Correia-Pinto
INTRODUCTION: We analyzed the department and surgeon learning curves during implementation of the percutaneous internal ring suturing (PIRS) technique in our department. METHODS: Children proposed for inguinal hernia or communicating hydrocele repair were included (n = 607). After mentorship, all surgeons were free to propose open or PIRS repair. From gathered data, we assessed department and surgeon learning curves through cumulative experience focusing in perioperative complications, conversion, ipsilateral recurrence, postoperative complications, and metachronous hernia, with benchmarks defined by open repair...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28985728/outcomes-identified-and-prioritised-by-consumers-of-partners-in-recovery-a-consumer-led-study
#20
Shifra Waks, Justin Newton Scanlan, Bridget Berry, Richard Schweizer, Nicola Hancock, Anne Honey
BACKGROUND: Recovery oriented service provisions means focusing on outcomes that are important to consumers themselves rather than to clinicians or services. Partners in Recovery (PIR) is an Australia-wide initiative designed to provide service coordination and brokerage for individuals with severe and persistent mental illness. One PIR service engaged a consumer-led research team to evaluate the service from the perspective of consumers. This consumer-led study was established to explore PIR consumers' perceptions of outcomes they achieved through their involvement with PIR...
October 6, 2017: BMC Psychiatry
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