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https://www.readbyqxmd.com/read/28197093/ultrastructural-and-functional-properties-of-a-giant-synapse-driving-the-piriform-cortex-to-mediodorsal-thalamus-projection
#1
Patric Pelzer, Heinz Horstmann, Thomas Kuner
Neocortico-thalamo-cortical loops represent a common, yet poorly understood, circuit employing giant synapses also referred to as "class I", giant, or driver synapses. Here, we characterize a giant synapse formed by projection neurons of the paleocortical piriform cortex (PIR) onto neurons of the mediodorsal thalamus (MD). Three-dimensional (3D) ultrastructure of labeled PIR-MD terminals, obtained by using serial-section scanning electron microscopy (EM) combined with photooxidation-based detection of labeled terminals, revealed a large terminal engulfing multiple postsynaptic dendritic excrescences...
2017: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/28193039/molecularly-imprinted-polymer-based-plasmonic-immunosandwich-assay-for-fast-and-ultrasensitive-determination-of-trace-glycoproteins-in-complex-samples
#2
Xueying Tu, Pir Muhammad, Jia Liu, Yanyan Ma, Shuangshou Wang, Danyang Yin, Zhen Liu
Glycoproteins play significant roles in many biological processes. Assays of glycoproteins have significant biological importance and clinical values, for which immunoassay has been the workhorse tool. However, immunoassay suffers from some disadvantages, such as poor availability of high-specificity antibodies and limited stability of biological reagents. Herein, we present an antibody-free and enzyme-free approach, called molecularly imprinted polymer (MIP)-based plasmonic immunosandwich assay (PISA), for fast and ultrasensitive detection of trace glycoproteins in complex samples...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28193002/organic-cyanide-decorated-sers-active-nanopipettes-for-quantitative-detection-of-hemeproteins-and-fe-3-in-single-cells
#3
Sumaira Hanif, Hailing Liu, Ming Chen, Pir Muhammad, Yue Zhou, Jiao Cao, Saud Asif Ahmed, Jingjuan Xu, Xinghua Xia, Hongyuan Chen, Kang Wang
It is challenging to develop a robust nanoprobe for real-time operational and accurate detection of heavy metals in single cells. Fe-CN coordination chemistry has been well studied to determine the structural characteristics of hemeproteins by different techniques. However, the frequently used cyanide ligands are inorganic molecules that release cyanide anion under particular conditions and cause cyanide poisoning. In the present study, organic cyanide (4-mercaptobenzonitrile, MBN) was utilized for the first time in developing a facile nanoprobe based on surface-enhanced Raman scattering (SERS) for quantitative detection of hemeproteins (oxy-Hb) and trivalent iron (Fe(3+)) ions...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28188942/photorefractive-keratectomy-with-mitomycin-c-for-high-myopia-three-year-follow-up-results
#4
Hassan Hashemi, Yahya Salimi, Poopak Pir, Soheila Asgari
Photorefractive keratectomy (PRK) is a safe and effective surgical keratorefractive technique which is done with the application of mitomycin-C (MMC) in cases of high myopia to prevent the formation of corneal haze This study was conducted to evaluate 3-year visual acuity and quality outcomes of PRK-MMC in high myopia. This before-after study was conducted on 20 individuals (40 eyes) with myopia more than 6.0 diopter (D). Visual acuity and quality indices were evaluated before and three years after the procedure and their stability was examined between the 1st and 3rd years...
January 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28169338/shrimp-ahpnd-causing-plasmids-encoding-the-pirab-toxins-as-mediated-by-pirab-tn903-are-prevalent-in-various-vibrio-species
#5
Jinzhou Xiao, Liyuan Liu, Yiyun Ke, Xiefei Li, Yunfei Liu, Yingjie Pan, Shuling Yan, Yongjie Wang
Acute hepatopancreatic necrosis disease (AHPND) is a newly emerging shrimp disease caused by pirAB toxins encoded by a plasmid found in Vibrio parahaemolyticus. The pirAB toxins are the homologs of the Photorhabdus insect-related (Pir) toxins. Here, we report the complete sequences of the AHPND-causing plasmid isolated from V. owensii, as well as those of its 11 siblings (pVH family). In addition, we also included 13 related plasmids (pVH-r family) without the pirAB genes isolated from a variety of species within the Vibrio Harveyi clade...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28165471/antibody-independent-mechanisms-regulate-the-establishment-of-chronic-plasmodium-infection
#6
Thibaut Brugat, Adam James Reid, Jing-Wen Lin, Deirdre Cunningham, Irene Tumwine, Garikai Kushinga, Sarah McLaughlin, Philip Spence, Ulrike Böhme, Mandy Sanders, Solomon Conteh, Ellen Bushell, Tom Metcalf, Oliver Billker, Patrick E Duffy, Chris Newbold, Matthew Berriman, Jean Langhorne
Malaria is caused by parasites of the genus Plasmodium. All human-infecting Plasmodium species can establish long-lasting chronic infections(1-5), creating an infectious reservoir to sustain transmission(1,6). It is widely accepted that the maintenance of chronic infection involves evasion of adaptive immunity by antigenic variation(7). However, genes involved in this process have been identified in only two of five human-infecting species: Plasmodium falciparum and Plasmodium knowlesi. Furthermore, little is understood about the early events in the establishment of chronic infection in these species...
February 6, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28153594/dose-dependent-effect-of-bisphenol-a-on-insulin-signaling-molecules-in-cardiac-muscle-of-adult-male-rat
#7
Preethi Sivashanmugam, Vigneswari Mullainadhan, Balasubramanian Karundevi
Environmental contaminant, Bisphenol-A (BPA) is a xenoestrogen, an essential component used for the production of two classes of polymers such as polycarbonate and epoxy resin which disrupts the normal endocrine function. BPA has intense effects on mice endocrine pancreas, an essential tissue involved in glucose metabolism. It disrupts pancreatic β-cell insulin content, induces hyperinsulinemia and insulin resistance in male rats. Cardiac muscle is an insulin responsive organ and insulin has direct effects on glucose transport...
January 30, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28152603/large-scale-and-targeted-quantitative-cross-linking-ms-using-isotope-labeled-protein-interaction-reporter-pir-cross-linkers
#8
Xuefei Zhong, Arti T Navare, Juan D Chavez, Jimmy K Eng, Devin K Schweppe, James E Bruce
Quantitative measurement of chemically cross-linked proteins is crucial to reveal dynamic information about protein structures and protein-protein interactions and how these are differentially regulated during stress, aging, drug treatment, and most perturbations. Previously, we demonstrated how quantitative in vivo cross-linking (CL) with stable isotope labeling of amino acids in cell culture (SILAC) enables both heritable and dynamic changes in cells to be visualized. In this work, we demonstrate the technical feasibility of proteome-scale quantitative in vivo CL-MS using isotope-labeled protein interaction reporter (PIR) cross-linkers and E...
February 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28150232/uniprot-protein-knowledgebase
#9
Sangya Pundir, Maria J Martin, Claire O'Donovan
The Universal Protein Resource (UniProt) is a freely available comprehensive resource for protein sequence and annotation data. UniProt is a collaboration between the European Bioinformatics Institute (EMBL-EBI), the Swiss Institute of Bioinformatics (SIB), and the Protein Information Resource (PIR). Across the three institutes more than 100 people are involved through different tasks such as expert curation, software development, and support.This chapter introduces the functionality and data provided by UniProt...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28135998/outcomes-of-a-care-coordinated-service-model-for-persons-with-severe-and-persistent-mental-illness-a-qualitative-study
#10
Anton N Isaacs, Keith Sutton, Kim Dalziel, Darryl Maybery
BACKGROUND: Owing to difficulties faced by individuals with severe and persistent mental illness (SPMI) in accessing multiple services, the Australian Government trialed a care coordinated service model called the Partners in Recovery (PIR) initiative. MATERIAL: A total of 45 stakeholders in Gippsland were asked what difference the initiative had made. DISCUSSION: The PIR initiative benefited not only clients and carers but also service providers...
February 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28133865/the-impact-of-the-chromium-supplementation-on-insulin-signalling-pathway-in-different-tissues-and-milk-yield-in-dairy-cows
#11
M Pantelić, L J Jovanović, R Prodanović, I Vujanac, M Đurić, T Ćulafić, S Vranješ-Đurić, G Korićanac, D Kirovski
Thirty days before expected time of parturition, 20 Holstein cows were divided into -Cr and +Cr groups. From day 25 before parturition (BP) up to day 30 after parturition (AP), +Cr cows received 10 mg of Cr (chromium-enriched yeast) daily. Muscle and adipose tissue samples were taken at days -30, -10, +7 and +10 related to parturition, when body condition score (BCS) was also determined. Hepatic tissue samples were taken at days -10 and +7. Tissue samples were used for determination of the insulin signalling pathway protein expressions...
January 30, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28122287/the-fluorescence-and-resonance-rayleigh-scattering-spectra-study-on-the-interactions-of-palladium-ii-nootropic-chelate-with-congo-red-and-their-analytical-applications
#12
Fang Chen, Jingdong Peng, Shaopu Liu, Huanjun Peng, Ziyu Pan, Lingli Bu, Huan Xiao, Ruiwen Zhang
A highly sensitive detection approach of resonance Rayleigh scattering spectra (RRS) is firstly applied to analyzing nootropic drugs including piracetam (PIR) and oxiracetam (OXI). In HCl-NaAc buffer solution (pH=3.0), the OXI chelated with palladium (II) to form the chelate cation [Pd2·OXI](2+), and then reacted with Congo red (CGR) by virtue of electrostatic attraction and hydrophobic force to form binary complex [Pd2·OXI]. CGR2, which could result in the great enhancement of RRS. The resonance Rayleigh scattering signal was recorded at λex=λem=375nm...
January 16, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28118657/association-of-intensive-care-unit-patient-to-intensivist-ratios-with-hospital-mortality
#13
Hayley B Gershengorn, David A Harrison, Allan Garland, M Elizabeth Wilcox, Kathryn M Rowan, Hannah Wunsch
Importance: The patient-to-intensivist ratio (PIR) across intensive care units (ICUs) is not standardized and the association of PIR with patient outcome is not well established. Understanding the impact of PIR on outcomes is necessary to optimize senior medical staffing and deliver high-quality care. Objective: To test the hypotheses that: (1) there is significant variation in the PIR across ICUs and (2) higher PIRs are associated with higher hospital mortality for ICU patients...
January 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28077829/-development-of-a-psychological-insulin-resistance-scale-for-korean-patients-with-diabetes
#14
Youngshin Song, Younghee Jeon, Jeonghwa Cho, Bohyun Kim
PURPOSE: This study was done to develop and validate a measure to evaluate the Korean version of psychological insulin resistance (K-PIR) in patients with diabetes in Korea. METHODS: Items were initially generated from literature reviews and interviews with 19 patients with diabetes. The content validity of the items was evaluated by experts. Participants were 424 patients with diabetes recruited through convenience sampling. A cross-sectional survey was designed for item-analysis, exploratory factor analysis with principal axis factoring, and confirmatory factor analysis...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28076968/influence-of-southwest-monsoons-in-the-kashmir-valley-western-himalayas
#15
Ghulam Jeelani, Rajendrakumar D Deshpande, Rouf A Shah, Wasim Hassan
The regional climate of the Himalayas is predominated by the southwest monsoons and the western disturbances. The uplift of the Pir Panjal to its present height is believed to restrict the southwest monsoons from entering into the Kashmir Valley in the western Himalayas. In the present study, monthly precipitation samples were collected across the Kashmir Valley from June 2013 to May 2014 for δ(18)O and δ(2)H analyses to constrain the influence of southwest monsoons in the valley. Except in August, the precipitation is enriched in (18)O and (2)H from June to September and depleted from October to May...
January 12, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28050022/an-isolate-of-vibrio-campbellii-carrying-the-pir-vp-gene-causes-acute-hepatopancreatic-necrosis-disease
#16
LETTER
Xuan Dong, Hailiang Wang, Guosi Xie, Peizhuo Zou, Chengcheng Guo, Yan Liang, Jie Huang
No abstract text is available yet for this article.
January 4, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28042769/discovery-of-an-unexplored-protein-structural-scaffold-of-serine-protease-from-big-blue-octopus-octopus-cyanea-a-new-prospective-lead-molecule
#17
Subhamay Panda, Leena Kumari
BACKGROUND: Serine proteases are a group of enzymes that hydrolyses the peptide bonds in proteins. In mammals, these enzymes help in the regulation of several major physiological functions such as digestion, blood clotting, responses of immune system, reproductive functions and the complement system. OBJECTIVE: Serine proteases obtained from the venom of Octopodidae family is a relatively unexplored area of research. In the present work, we tried to effectively utilize comparative composite molecular modeling technique...
January 2, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28008421/a-new-plasmodium-vivax-reference-sequence-with-improved-assembly-of-the-subtelomeres-reveals-an-abundance-of-pir-genes
#18
Sarah Auburn, Ulrike Böhme, Sascha Steinbiss, Hidayat Trimarsanto, Jessica Hostetler, Mandy Sanders, Qi Gao, Francois Nosten, Chris I Newbold, Matthew Berriman, Ric N Price, Thomas D Otto
Plasmodium vivax is now the predominant cause of malaria in the Asia-Pacific, South America and Horn of Africa. Laboratory studies of this species are constrained by the inability to maintain the parasite in continuous ex vivo culture, but genomic approaches provide an alternative and complementary avenue to investigate the parasite's biology and epidemiology. To date, molecular studies of P. vivax have relied on the Salvador-I reference genome sequence, derived from a monkey-adapted strain from South America...
November 15, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28006879/microbiological-characteristics-of-perianal-streptococcal-dermatitis-a-retrospective-study-of-105-patients-in-a-10-year-period
#19
Anja Šterbenc, Katja Seme, Liza Lea Lah, Olga Točkova, Tina Kamhi Trop, Nataša Švent-Kučina, Mateja Pirš
Beta-hemolytic streptococci (BHS) are the most common causative agents of perianal streptococcal dermatitis (PSD). This study evaluates the distribution of BHS isolates in perianal bacterial cultures. We retrospectively reviewed microbiological results for perianal BHS that were isolated in our laboratory between 2006 and 2015. We identified a total of 105 BHS isolates from rectal swabs and swabs of clinically intact perianal skin. The majority of BHS were of group A (GABHS) (73/105; 69.5%), followed by group B BHS (GBBHS) (27/105; 25...
December 2016: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/27976750/compass-continuous-open-mouse-phenotyping-of-activity-and-sleep-status
#20
Laurence A Brown, Sibah Hasan, Russell G Foster, Stuart N Peirson
Background  Disruption of rhythms in activity and rest occur in many diseases, and provide an important indicator of healthy physiology and behaviour. However, outside the field of sleep and circadian rhythm research, these rhythmic processes are rarely measured due to the requirement for specialised resources and expertise. Until recently, the primary approach to measuring activity in laboratory rodents has been based on voluntary running wheel activity. By contrast, measuring sleep requires the use of electroencephalography (EEG), which involves invasive surgical procedures and time-consuming data analysis...
2016: Wellcome Open Res
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