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https://www.readbyqxmd.com/read/29762174/reasons-for-non-adherence-to-the-dapivirine-vaginal-ring-results-of-the-mtn-032-aha-study
#1
Elizabeth T Montgomery, Jonathan Stadler, Sarita Naidoo, Ariana Katz, Nicole Laborde, Morgan Garcia, Krishnaveni Reddy, Leila Mansoor, Juliane Etima, Chifundo Zimba, Miria Chitukuta, Lydia Soto-Torres
OBJECTIVE(S): METHODS:: Former ASPIRE participants were stratified by age group (18-21; 22-45) and randomly selected at seven sites in Malawi, South Africa, Uganda and Zimbabwe, 12-17 months after trial exit. Using in-depth interviews or focus group discussions, ring use barriers were explored using structured guides and visual tools including individual-level depictions of dapivirine levels detected in plasma and returned rings. RESULTS: 187 were enrolled; 37% were 18-21 when they began ASPIRE...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29747875/young-adults-opioid-use-trajectories-from-nonmedical-prescription-opioid-use-to-heroin-drug-injection-drug-treatment-and-overdose
#2
Honoria Guarino, Pedro Mateu-Gelabert, Jennifer Teubl, Elizabeth Goodbody
INTRODUCTION: Recent research has begun to explore the transition from nonmedical use of prescription opioids (POs) to heroin and injection drug use, adding to earlier literature identifying factors that influence the transition from intranasal to injection use of heroin. However, little research has explored how these transitions are embedded within young people's broader opioid use trajectories - individual pathways that may also include experiences of nonfatal overdose and drug treatment...
May 1, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29733742/are-ecstasy-induced-serotonergic-alterations-overestimated-for-the-majority-of-users
#3
Balázs Szigeti, Adam R Winstock, David Erritzoe, Larissa J Maier
BACKGROUND: Neuroimaging studies imply that the regular use of ±3,4-methylenedioxymethamphetamine (MDMA), the major constituent of ecstasy pills, alters the brain's serotonergic system in a dose-dependent manner. However, the relevance of these findings remains unclear due to limited knowledge about the ecstasy/MDMA use pattern of real-life users. AIMS: We examined the representativeness of ecstasy users enrolled in neuroimaging studies by comparing their ecstasy use habits with the use patterns of a large, international sample...
May 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29732728/dyspepsia-in-non-steroidal-anti-inflammatory-drug-users-and-the-effect-of-preventive-measures
#4
Hooi Leng Lee, Siew Siang Chua, Sanjiv Mahadeva
BACKGROUND/AIMS: Dyspepsia is the commonest gastrointestinal (GI) adverse effect of non-steroidal anti-inflammatory drugs (NSAID). The effects of preventive measures and their adherence from a real-world perspective have been little reported. METHODS: A prospective longitudinal study was conducted among outpatients with regular NSAID usage. The presence of dyspepsia (assessed by locally validated versions of the Leeds Dyspepsia Questionnaire (LDQ), gastric preventive agents (GPA) and their adherence were assessed at recruitment and two weeks later...
May 7, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29707771/nonsteroidal-anti-inflammatory-drug-use-and-breast-cancer-risk-in-a-european-prospective-cohort-study
#5
Manon Cairat, Agnès Fournier, Neil Murphy, Carine Biessy, Augustin Scalbert, Sabina Rinaldi, Anne Tjønneland, Anja Olsen, Kim Overvad, Patrick Arveux, Marie-Christine Boutron-Ruault, Claire Cadeau, Renée Turzanski Fortner, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Petra H M Peeters, Carla H Van Gils, Nicholas J Wareham, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Marc J Gunter, Laure Dossus
Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to assess the association between NSAID use and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Self-reported information on NSAID use at baseline has been collected in five EPIC countries...
April 29, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29684763/regular-past-year-cannabis-use-in-women-veterans-and-associations-with-sexual-trauma
#6
Kendall C Browne, Marketa Dolan, Tracy L Simpson, John C Fortney, Keren Lehavot
INTRODUCTION: This study sought to describe the prevalence of regular past year cannabis use (i.e., at least monthly use) in women veterans, to characterize women veterans reporting this level of use, and to examine the independent contributions of sexual trauma across the lifespan on regular past year cannabis use. METHODS: A national online survey on women veterans' health, with targeted oversampling of lesbian and bisexual women, collected data from US armed forces women veterans, 18 or older, living in the US (N = 636)...
April 10, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29680678/concomitant-use-of-buprenorphine-for-medication-assisted-treatment-of-opioid-use-disorder-and-benzodiazepines-using-the-prescription-behavior-surveillance-system
#7
Yanmin Zhu, D Tyler Coyle, Mohamed Mohamoud, Esther Zhou, Efe Eworuke, Catherine Dormitzer, Judy Staffa
BACKGROUND: Despite clinical guidelines discouraging the practice, it is well-documented that the concomitant use of benzodiazepines and opioid analgesics occurs regularly. Information on concomitant use of buprenorphine for medication-assisted treatment (MAT) of opioid use disorder (OUD) and benzodiazepines, however, is limited. Thus, we aimed to describe real-world drug dispensing patterns for the concomitant use of buprenorphine products approved for MAT and benzodiazepines. METHODS: We examined concomitant use of buprenorphine for MAT and benzodiazepines using the 2013 Prescription Behavior Surveillance System data from eight states...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29661657/reprint-of-the-effect-of-n-acetylcysteine-and-working-memory-training-on-cocaine-use-craving-and-inhibition-in-regular-cocaine-users-correspondence-of-lab-assessments-and-ecological-momentary-assessment
#8
Mieke H J Schulte, Reinout W Wiers, Wouter J Boendermaker, Anna E Goudriaan, Wim van den Brink, Denise S van Deursen, Malte Friese, Emily Brede, Andrew J Waters
INTRODUCTION: Effective treatment for cocaine use disorder should dampen hypersensitive cue-induced motivational processes and/or strengthen executive control. Using a randomized, double-blind, placebo-controlled intervention, the primary aim of this study was to investigate the effect of N-Acetylcysteine (NAC) and working memory (WM)-training to reduce cocaine use and craving and to improve inhibition assessed in the laboratory and during Ecological Momentary Assessment (EMA). The second aim was to examine correspondence between laboratory and EMA data...
March 26, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29630030/hiv-serostatus-and-having-access-to-a-physician-for-regular-hepatitis-c-virus-care-among-people-who-inject-drugs
#9
Tara Beaulieu, Kanna Hayashi, Michael J Milloy, Ekaterina Nosova, Kora DeBeck, Julio Montaner, Thomas Kerr, Lianping Ti
BACKGROUND: People who inject drugs (PWIDs) and who are living with HIV and hepatitis C virus (HCV) infection are vulnerable to a range of health-related harms, including liver cirrhosis, hepatocellular carcinoma, and death. There is limited evidence describing how HIV serostatus shapes access to a physician for regular HCV care among PWID. SETTING: Data were collected through the Vancouver Injection Drug Users Study (VIDUS), the AIDS Care Cohort to evaluate Exposure to Survival Services (ACCESS), and the At-Risk Youth Study (ARYS), 3 prospective cohorts involving people who use illicit drugs in Vancouver, Canada, between 2005 and 2015...
May 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29607409/a-novel-observational-method-for-assessing-acute-responses-to-cannabis-preliminary-validation-using-legal-market-strains
#10
L Cinnamon Bidwell, Raeghan Mueller, Sophie L YorkWilliams, Sarah Hagerty, Angela D Bryan, Kent E Hutchison
Background: The development of novel cannabis research methods that are compatible with current federal regulations is imperative to conduct studies of the effects of legal market cannabis. There is very little research on higher strength, higher Δ9-tetrahydrocannabinol (THC), which has become increasingly available since legalization. Research on strains containing cannabidiol (CBD), a second primary, but nonpsychotomimetic, cannabinoid, is very limited. Materials and Methods: Using a novel observational methodology, regular cannabis users were asked to use one of two legal market cannabis strains that they purchased from a local dispensary (one strain containing 8% THC and 16% CBD (THC+CBD) and one containing a 17% THC concentration, but no CBD (THC)...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29593581/enhanced-amygdala-striatal-functional-connectivity-during-the-processing-of-cocaine-cues-in-male-cocaine-users-with-a-history-of-childhood-trauma
#11
Anne Marije Kaag, Liesbeth Reneman, Judith Homberg, Wim van den Brink, Guido A van Wingen
Background and aims: Childhood trauma is associated with increased levels of anxiety later in life, an increased risk for the development of substance use disorders, and neurodevelopmental abnormalities in the amygdala and frontostriatal circuitry. The aim of this study was to investigate the (neurobiological) link among childhood trauma, state anxiety, and amygdala-frontostriatal activity in response to cocaine cues in regular cocaine users. Methods: In this study, we included 59 non-treatment seeking regular cocaine users and 58 non-drug using controls...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29553354/decreasing-hiv-syphilis-and-hepatitis-c-infection-after-a-decade-of-harm-reduction-implementation-among-drug-users-in-southwestern-areas-of-china
#12
Yi Chen, Zhenzhu Tang, Shuai Tang, Zhiyong Shen, Qiuying Zhu, Rongjian Li, Wenbo Huang, Yuman Huang, Fuxiong Liang, Lu Wang, Huanhuan Chen, Yuhua Ruan, Yiming Shao, Sian Hsiang-Te Tsuei, Guanghua Lan
OBJECTIVE: Since 2003, the Chinese central government has implemented several harm reduction and preventive measures to control HIV. We aim to describe epidemiological trends of HIV, hepatitis C virus (HCV), and syphilis in Guangxi drug users after the policy implementation. METHOD: A total of 12,161-15,870 drug users in Guangxi, China, were recruited annually from 2009 to 2015 through community outreach or snowball sampling. The participants' demographics, behavior, and infection status were used to characterize rates of protective behaviors and disease prevalence (HIV, syphilis, and HCV)...
March 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29553279/trends-in-opioid-and-nonsteroidal-anti-inflammatory-use-and-adverse-events
#13
Veronica Fassio, Sherrie L Aspinall, Xinhua Zhao, Donald R Miller, Jasvinder A Singh, Chester B Good, Francesca E Cunningham
OBJECTIVES: To describe the prevalence and incidence of opioid and nonsteroidal anti-inflammatory drug (NSAID) use before and since the start of the Veterans Health Administration (VHA) Opioid Safety Initiative (OSI) and to assess rates of adverse events (AEs). STUDY DESIGN: Historical cohort study. METHODS: The OSI began in August 2012 and was fully implemented by the end of fiscal year (FY) 2013. The study timeframe was categorized into baseline (FY 2011-2012), transition (FY 2013), and postimplementation (FY 2014-2015) phases...
March 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29551051/treatment-patterns-of-knee-osteoarthritis-patients-in-korea
#14
Ha-Rim Park, Soo-Kyung Cho, Seul Gi Im, Sun-Young Jung, Dalho Kim, Eun Jin Jang, Yoon-Kyoung Sung
Background/Aims: To evaluate the treatment patterns of knee osteoarthritis (OA) patients in South Korea. Methods: Using the Korean nationwide claims database, all knee OA patients in Korea during 2014 were identified by the knee OA diagnostic code (M17) or any OA diagnostic code (M15 to M19) in combination with a procedure for a knee X-ray. Patterns of medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids (CSs), analgesics, and symptomatic slow acting drugs for OA (SYSADOA) were analyzed...
March 21, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29544599/sex-drugs-and-social-connectedness-wellbeing-among-hiv-positive-gay-and-bisexual-men-who-use-party-and-play-drugs
#15
Jennifer Power, Gosia Mikołajczak, Adam Bourne, Graham Brown, William Leonard, Anthony Lyons, Gary W Dowsett, Jayne Lucke
Background This paper explores associations between use of party-and-play drugs, including crystal methamphetamine, and wellbeing among HIV positive gay and bisexual men (GBM) in Australia. This study considers whether use of drugs in a social or sex-based setting facilitates access to social and support networks, which may in turn support wellbeing. METHODS: A cross-sectional survey of Australian people living with HIV (PLHIV) was conducted. There were 714 participants (79.7%) who identified as GBM...
April 2018: Sexual Health
https://www.readbyqxmd.com/read/29501928/the-perspectives-of-structurally-vulnerable-people-who-use-drugs-on-volunteer-stipends-and-work-experiences-provided-through-a-drug-user-organization-opportunities-and-limitations
#16
Geoff Bardwell, Solanna Anderson, Lindsey Richardson, Lorna Bird, Hugh Lampkin, Will Small, Ryan McNeil
BACKGROUND: While drug user organizations (DUO) have received public health attention as a means to potentially reduce the harms associated with drug use, there is a lack of research on the compensation and structural forces that promote or inhibit participation in DUO. Against the backdrop of structural vulnerability experienced by people who use drugs (PWUD), we examined the impact of monetary 'volunteer stipends' provided through a DUO and explore their role in providing low-threshold employment opportunities and shaping participation in DUO...
March 1, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29487874/epidemiological-profile-and-risk-factors-for-acquiring-hbv-and-or-hcv-in-hiv-infected-population-groups-in-nepal
#17
Manjula Bhattarai, Jagat Bahadur Baniya, Nirmal Aryal, Bimal Shrestha, Ramanuj Rauniyar, Anurag Adhikari, Pratik Koirala, Pardip Kumar Oli, Ram Deo Pandit, David A Stein, Birendra Prasad Gupta
HBV and HCV infections are widespread among the HIV-infected individuals in Nepal. The goals of this study were to investigate the epidemiological profile and risk factors for acquiring HBV and/or HCV coinfection in disadvantaged HIV-positive population groups in Nepal. We conducted a retrospective study on blood samples from HIV-positive patients from the National Public Health Laboratory at Kathmandu to assay for HBsAg, HBeAg, and anti-HCV antibodies, HIV viral load, and CD4+ T cell count. Among 579 subjects, the prevalence of HIV-HBV, HIV-HCV, and HIV-HBV-HCV coinfections was 3...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29452067/alcohol-and-drug-use-among-deaf-and-hard-of-hearing-individuals-a-secondary-analysis-of-nhanes-2013-2014
#18
Melissa L Anderson, Bei-Hung Chang, Nisha Kini
BACKGROUND: Within the field of behavioral health research, one of the most understudied populations is the US deaf and hard-of-hearing (D/HH) population-a diverse group of individuals with hearing loss that have varied language and communication preferences, community affiliations, and sociocultural norms. Recent research identified concerning behavioral health disparities experienced by the D/HH population; yet, little research has been conducted to extend these findings to the topic of substance use disorder...
February 16, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29450253/drug-nicotine-and-alcohol-use-among-exercisers-does-substance-addiction-co-occur-with-exercise-addiction
#19
Attila Szabo, Mark D Griffiths, Rikke Aarhus Høglid, Zsolt Demetrovics
Background: Scholastic works suggest that those at risk for exercise addiction are also often addicted to illicit drugs, nicotine, and/or alcohol, but empirical evidence is lacking. Aims: The aim of the present work was to examine the co-occurrence of illicit drug, nicotine, and alcohol use frequency (prevalence of users) and severity (level of problem in users) among exercisers classified at three levels of risk for exercise addiction: (i) asymptomatic, (ii) symptomatic, and (iii) at-risk...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29425227/interaction-between-polymorphisms-in-aspirin-metabolic-pathways-regular-aspirin-use-and-colorectal-cancer-risk-a-case-control-study-in-unselected-white-european-populations
#20
Harsh Sheth, Emma Northwood, Cornelia M Ulrich, Dominique Scherer, Faye Elliott, Jennifer H Barrett, David Forman, C Roland Wolf, Gillian Smith, Michael S Jackson, Mauro Santibanez-Koref, Robert Haile, Graham Casey, Mark Jenkins, Aung Ko Win, John L Hopper, Loic Le Marchand, Noralane M Lindor, Stephen N Thibodeau, John D Potter, John Burn, D Timothy Bishop
Regular aspirin use is associated with reduced risk of colorectal cancer (CRC). Variation in aspirin's chemoprevention efficacy has been attributed to the presence of single nucleotide polymorphisms (SNPs). We conducted a meta-analysis using two large population-based case-control datasets, the UK-Leeds Colorectal Cancer Study Group and the NIH-Colon Cancer Family Registry, having a combined total of 3325 cases and 2262 controls. The aim was to assess 42 candidate SNPs in 15 genes whose association with colorectal cancer risk was putatively modified by aspirin use, in the literature...
2018: PloS One
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