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https://www.readbyqxmd.com/read/28817784/hydrogen-peroxide-regulates-angiogenesis-related-factors-in-tumor-cells
#1
Ana Jerónimo, Gonçalo Rodrigues, Filipe Vilas-Boas, Gabriel G Martins, Ana Bagulho, Carla Real
Tumor angiogenesis is required for tumor development and growth and is regulated by several factors including reactive oxygen species (ROS). Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is a ROS with an important role in cell signaling but how H<sub>2</sub>O<sub>2</sub> regulates tumor angiogenesis is still poorly understood. We have xenografted tumor cells with altered levels of H<sub>2</sub>O<sub>2</sub> by catalase overexpression into zebrafish embryos to study redox-induced tumor neovascularization...
August 17, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28817777/predicting-nox-catalysis-by-quantifying-ce-3-from-surface-and-lattice-oxygen
#2
Vinod Kumar Paidi, Louisa Savereide, David J Childers, Justin M Notestein, Charles Alexander Roberts, Johan van Lierop
Our work introduces a novel technique based on the magnetic response of Ce(3+) and molecular oxygen adsorbed on the surface of nanoceria and ceria-based catalysts that quantifies the number and type of defects, and demonstrates that this information is the missing link that finally enables predictive design of NOx catalysis in ceria-based systems. The new insights into ceria catalysis are enabled by quantifying the above for different ceria nanoparticle shapes (i.e. surface terminations) and O2 partial pressure...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28817770/photoinduced-copper-catalyzed-alkylation-of-amines-a-mechanistic-study-of-the-cross-coupling-of-carbazole-with-alkyl-bromides
#3
Jun Myun Ahn, Tanvi S Ratani, Kareem Hannoun, Gregory C Fu, Jonas C Peters
We have recently reported that a variety of couplings of nitrogen, sulfur, oxygen, and carbon nucleophiles with organic halides can be achieved under mild conditions (-40 to 30 °C) through the use of light and a copper catalyst. Insight into the various mechanisms by which these reactions proceed may enhance our understanding of chemical reactivity and facilitate the development of new methods. In this report, we apply an array of tools (EPR, NMR, transient absorption, and UV-vis spectroscopy; ESI-MS; X-ray crystallography; DFT calculations; reactivity, stereochemical, and product studies) to investigate the photoinduced, copper-catalyzed coupling of carbazole with alkyl bromides...
August 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28817701/effect-of-exoskeletal-joint-constraint-and-passive-resistance-on-metabolic-energy-expenditure-implications-for-walking-in-paraplegia
#4
Sarah R Chang, Rudi Kobetic, Ronald J Triolo
An important consideration in the design of a practical system to restore walking in individuals with spinal cord injury is to minimize metabolic energy demand on the user. In this study, the effects of exoskeletal constraints on metabolic energy expenditure were evaluated in able-bodied volunteers to gain insight into the demands of walking with a hybrid neuroprosthesis after paralysis. The exoskeleton had a hydraulic mechanism to reciprocally couple hip flexion and extension, unlocked hydraulic stance controlled knee mechanisms, and ankles fixed at neutral by ankle-foot orthoses...
2017: PloS One
https://www.readbyqxmd.com/read/28817659/resveratrol-improves-alcoholic-fatty-liver-disease-by-downregulating-hif-1%C3%AE-expression-and-mitochondrial-ros-production
#5
Zhenhua Ma, Yangmin Zhang, Qingchun Li, Meng Xu, Jigang Bai, Shengli Wu
Oxidative stress has been demonstrated to be involved in the etiology of alcoholic fatty liver disease (AFLD). Previous studies had demonstrated that resveratrol (RES) could reduce oxidative stress by different mechanisms. However, the effect of RES on alcohol-induced fatty liver remains unclear. In the present study, a total of 48 male SD rats were divided into three groups: Control, AFLD, and RES groups. Rats were administered with either nothing or 65% vol/vol alcohol (5 ml/kg/day in the first three days, and then 10 ml/kg/day in the following days) with or without RES supplementation (250 mg/kg/day) for 4 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28817623/metformin-attenuates-myocardial-ischemia-reperfusion-injury-via-up-regulation-of-antioxidant-enzymes
#6
Xiaoling Wang, Lei Yang, Licheng Kang, Jing Li, Liang Yang, Jincai Zhang, Jie Liu, Mengmeng Zhu, Qiong Zhang, Yanna Shen, Zhi Qi
The objective was to examine the protective effect of metformin (Met) on myocardial ischemia-reperfusion (IR) injury and whether the mechanism was related to the AMPK/ antioxidant enzymes signaling pathway. Rat Langendorff test and H2O2-treated rat cardiomyocytes (H9c2) were used in this study. Met treatment significantly improved left ventricular (LV) function, reduced infarct size and CK-MB release in comparison with IR group. Decreased TUNEL staining positive cells were also observed in IR+Met group ex vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28817291/assembly-of-2-arylbenzothiazoles-through-three-component-oxidative-annulation-under-transition-metal-free-conditions
#7
Xingzong Che, Jingjing Jiang, Fuhong Xiao, Huawen Huang, Guo-Jun Deng
Highly efficient methods for the synthesis of 2-arylbenzothiazoles and 2-arylnaphtho[2,1-d]thiazoles have been developed. Readily available aromatic amines, benzaldehydes, and elemental sulfur were directly assembled through oxidative annulation and C-H functionalization under transition-metal-free conditions, where DMSO or oxygen served as the oxidant. NH4I or KI as the catalyst was found to be effective to promote the transformations to give the annulation products in good to excellent yields with wide functional group tolerance...
August 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/28817279/soft-chemical-fabrication-of-iron-based-thin-film-electrocatalyst-for-water-oxidation-under-neutral-ph-and-structure-activity-tuning-by-cerium-incorporation
#8
Jony Saha, T P Radhakrishnan
Design of electrocatalysts for the fundamentally important oxygen evolution reaction can be greatly aided by systematic structure-activity tuning via composition variation. We have explored the iron-cerium system as they are the most abundant transition and rare earth metals, and also due to the mutualistic impact of their size and electronic attributes that can induce critical changes in the structure and electrochemical activity. Submicrometer thick films of a series of Fe(III)-Ce(III) phosphate(oxyhydroxide) (FeCePH) are fabricated using a soft chemical strategy involving surfactant-aided assembly, spin-coating, and mild thermal annealing...
August 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28817264/structural-diversities-in-heterometallic-mn-ca-cluster-chemistry-from-the-use-of-salicylhydroxamic-acid-mn-iii-4ca2-mn-ii-iii-6ca2-mn-iii-iv-8ca-and-mn-iii-8ca2-complexes-with-relevance-to-both-high-and-low-valent-states-of-the-oxygen-evolving-complex
#9
Alysha A Alaimo, Evangelia S Koumousi, Luís Cunha-Silva, Laura J McCormick, Simon J Teat, Vassilis Psycharis, Catherine P Raptopoulou, Shreya Mukherjee, Chaoran Li, Sayak Das Gupta, Albert Escuer, George Christou, Theocharis C Stamatatos
One-pot reactions between the [Mn3O(O2CPh)6(py)x](+/0) triangular precursors and either CaBr2·xH2O or CaCl2·6H2O, in the presence of salicylhydroxamic acid (shaH2), have afforded the heterometallic complexes [Mn(III)4Ca2(O2CPh)4(shi)4(H2O)3(Me2CO)] (1) and (pyH)[Mn(II)2Mn(III)4Ca2Cl2(O2CPh)7(shi)4(py)4] (2), respectively, in good yields. Further reactions but using a more flexible synthetic scheme comprising the Mn(NO3)2·4H2O/Ca(NO3)2·4H2O and Mn(O2CPh)2·2H2O/Ca(ClO4)2·4H2O "metal blends" and shaH2, in the presence of external base NEt3, led to the new complexes (NHEt3)2[Mn(III)4Mn(IV)4Ca(OEt)2(shi)10(EtOH)2] (3) and (NHEt3)4[Mn(III)8Ca2(CO3)4(shi)8] (4), respectively...
August 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28817262/electrical-and-structural-characterization-of-ba3mo1-xnb1-xo8-5-x-2-the-relationship-between-mixed-coordination-polyhedral-distortion-and-the-ionic-conductivity-of-ba3monbo8-5
#10
Sacha Fop, Eve J Wildman, Janet M S Skakle, Clemens Ritter, Abbie C Mclaughlin
The electrical and structural properties of the series Ba3Mo1-xNb1+xO8.5-x/2 (x = 0.0, 0.1, 0.2, 0.3) have been determined. Ba3Mo1-xNb1+xO8.5-x/2 crystallizes in a hybrid of the 9R hexagonal perovskite and palmierite structures, in which (Mo/Nb)O4 and (Mo/Nb)O6 units coexist within the structure. Nb substitutes preferentially at the octahedral site so that the ratio of (Mo/Nb)O4 tetrahedra to (Mo/Nb)O6 octahedra decreases with increasing x resulting in a reduction in the magnitude of the ionic conductivity from 1...
August 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28817079/insight-into-the-mechanism-of-co-oxidation-on-wo%C3%A2-001-surfaces-for-gas-sensing-a-dft-study
#11
Hua Jin, Hegen Zhou, Yongfan Zhang
The mechanism of CO oxidation on the WO₃(001) surface for gas sensing performance has been systematically investigated by means of first principles density functional theory (DFT) calculations. Our results show that the oxidation of CO molecule on the perfect WO₃(001) surface induces the formation of surface oxygen vacancies, which results in an increase of the surface conductance. This defective WO₃(001) surface can be re-oxidized by the O₂ molecules in the atmosphere. During this step, the active O₂(-) species is generated, accompanied with the obvious charge transfer from the surface to O₂ molecule, and correspondingly, the surface conductivity is reduced...
August 17, 2017: Sensors
https://www.readbyqxmd.com/read/28817064/attenuation-of-multiple-organ-damage-by-continuous-low-dose-solvent-free-infusions-of-resveratrol-after-severe-hemorrhagic-shock-in-rats
#12
Tobias Müller, Michael Kirsch, Frank Petrat
Therapeutic effects of continuous intravenous infusions of solvent-free low doses of resveratrol on organ injury and systemic consequences resulting from severe hemorrhagic shock in rats were studied. Hemorrhagic shock was induced by withdrawing arterial blood until a mean arterial blood pressure (MAP) of 25-30 mmHg was reached. Following a shock phase of 60 min, rats were resuscitated with the withdrawn blood plus lactated Ringer's. Resveratrol (20 or 60 μg/kg × h) was continuously infused intravenously starting with the resuscitation phase (30 min) and continued until the end of the experiment (total treatment time 180 min)...
August 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28816938/advanced-glycation-end-products-promote-chrebp-expression-and-cell-proliferation-in-liver-cancer-cells-by-increasing-reactive-oxygen-species
#13
Hanbei Chen, Yakui Li, Yemin Zhu, Lifang Wu, Jian Meng, Ning Lin, Dianqiang Yang, Minle Li, WenJin Ding, Xuemei Tong, Qing Su
The aim of the study was to elucidate the mechanism by which advanced glycation end products (AGEs) promote cell proliferation in liver cancer cells.We treated liver cancer HepG2 cells with 200 mg/L AGEs or bovine serum albumin (BSA) and assayed for cell viability, cell cycle, and apoptosis. We performed real-time PCR and Western blot analysis for RNA and protein levels of carbohydrate responsive element-binding protein (ChREBP) in AGEs- or BSA-treated HepG2 cells. We analyzed the level of reactive oxygen species (ROS) in HepG2 cells treated with AGEs or BSA...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816922/nil-whey-protein-effect-on-glycaemic-control-after-intense-mixed-mode-training-in-t2d
#14
Kim A Gaffney, Adam Lucero, Lee Stoner, James Faulkner, Patricia Whitfield, Jeremy Krebs, David S Rowlands
While intense endurance and resistance exercise training and whey protein supplementation have both been shown to independently improve glycaemic control, no known studies have examined the effect of high-intensity mixed-mode interval training (MMIT) and whey supplementation in adults with Type-2 diabetes (T2D). PURPOSE: To determine if peri-training whey protein supplementation combined with MMIT can improve glycaemic control. METHODS: In a double-blind randomised controlled trial, 24 men (55...
August 14, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28816920/similar-metabolic-innate-immunity-and-adipokine-profiles-in-adult-and-pediatric-sepsis-versus-systemic-inflammatory-response-syndrome-a-pilot-study
#15
Theonymfi Tavladaki, Anna Maria Spanaki, Helen Dimitriou, Efmorfia Kondili, Christianna Choulaki, Dimitris Georgopoulos, George Briassoulis
OBJECTIVES: To examine whether the septic profiles of heat shock protein 72, heat shock protein 90α, resistin, adiponectin, oxygen consumption, CO2 production, energy expenditure, and metabolic pattern, along with illness severity, nutritional, and inflammatory indices, differ between adult and pediatric patients compared with systemic inflammatory response syndrome and healthy controls. To evaluate whether these biomolecules may discriminate sepsis from systemic inflammatory response syndrome in adult and pediatric patients...
August 12, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28816883/cerebral-oxygen-saturation-during-electroconvulsive-therapy-a-secondary-analysis-of-a-randomized-crossover-trial
#16
Kamath Sriganesh, Tanmay Jadhav, Sudhir Venkataramaiah, Channaveerachari Naveen Kumar, Shyamsundar Armugham, Mariamma Philip, K R Madhusudan Reddy, Jagadisha Thirthalli, G S Umamaheswara Rao
BACKGROUND: Electroconvulsive therapy (ECT) causes acute changes in cerebral perfusion and oxygenation. Near-infrared spectroscopy is a novel, noninvasive technique to assess cerebral oxygen saturation (cSO2). We hypothesized that cSO2 increases during ECT and more so with atropine premedication and decreases when systemic desaturation (peripheral oxygen saturation <90%) occurs during ECT. METHODS: We performed a secondary analysis of a randomized trial of patients undergoing ECT for psychiatric illness during a 6-month period...
August 14, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28816773/synergistic-antitumor-effect-of-3-bromopyruvate-and-5-fluorouracil-against-human-colorectal-cancer-through-cell-cycle-arrest-and-induction-of-apoptosis
#17
Dianlong Chong, Linyan Ma, Fang Liu, Zhirui Zhang, Surong Zhao, Qiang Huo, Pei Zhang, Hailun Zheng, Hao Liu
3-Bromopyruvic acid (3-BP) is a well-known inhibitor of energy metabolism. It has been proposed as an anticancer agent as well as a chemosensitizer for use in combination with anticancer drugs. 5-Fluorouracil (5-FU) is the first-line chemotherapeutic agent for colorectal cancer; however, most patients develop resistance to 5-FU through various mechanisms. The aim of this study was to investigate whether 3-BP has a synergistic antitumor effect with 5-FU on human colorectal cancer cells. In our study, combined 3-BP and 5-FU treatment upregulated p53 and p21, whereas cyclin-dependent kinase CDK4 and CDK2 were downregulated, which led to G0/G1 phase arrest...
September 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28816683/cardiorespiratory-model-based-data-driven-approach-for-sleep-apnea-detection
#18
Sandeep Gutta, Qi Cheng, Hoa Nguyen, Bruce Benjamin
Obstructive sleep apnea (OSA) is a chronic sleep disorder affecting millions of people worldwide. Individuals with OSA are rarely aware of the condition and are often left untreated, which can lead to some serious health problems. Nowadays, several low-cost wearable health sensors are available that can be used to conveniently and noninvasively collect a wide range of physiological signals. In this paper, we propose a new framework for OSA detection in which we combine the wearable sensor measurement signals with the mathematical models of the cardiorespiratory system...
August 14, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28816645/a-systems-model-of-parkinson-s-disease-using-biochemical-systems-theory
#19
Hemalatha Sasidharakurup, Nidheesh Melethadathil, Bipin Nair, Shyam Diwakar
Parkinson's disease (PD), a neurodegenerative disorder, affects millions of people and has gained attention because of its clinical roles affecting behaviors related to motor and nonmotor symptoms. Although studies on PD from various aspects are becoming popular, few rely on predictive systems modeling approaches. Using Biochemical Systems Theory (BST), this article attempts to model and characterize dopaminergic cell death and understand pathophysiology of progression of PD. PD pathways were modeled using stochastic differential equations incorporating law of mass action, and initial concentrations for the modeled proteins were obtained from literature...
August 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28816631/platypnea-orthodeoxia-syndrome-an-unusual-presentation-of-a-complex-disease
#20
Tess Van Meerhaeghe, Steven Droogmans, Shane Hanon, Jeroen Sonck
BACKGROUND: Platypnea-orthodeoxia syndrome (POS) is an uncommon disorder characterized by dyspnea (=platypnea) and desaturation (=orthodeoxia) in upright position and improvement of symptoms and blood oxygenation in supine position. Clinical presentation is heterogeneous and often confuses the clinician. OBJECTIVES: The present case report illustrates a complicated presentation of the underlying syndrome. METHODS: Description of a POS case in a 73-year-old female with thorough workup and tailored treatment...
August 17, 2017: Acta Clinica Belgica
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