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Preclampsia

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https://www.readbyqxmd.com/read/27697222/modulation-of-fabp4-hypomethylation-by-dnmt1-and-its-inverse-interaction-with-mir-148a-152-in-the-placenta-of-preeclamptic-rats-and-htr-8-cells
#1
Anning Yang, Huiping Zhang, Yue Sun, Yanhua Wang, Xiaoming Yang, Xiaoling Yang, Hui Zhang, Wei Guo, Guangrong Zhu, Jue Tian, Yuexia Jia, Yideng Jiang
Inflammation and dysregulated lipid metabolism are involved in the pathogenesis of preeclampsia, and fatty acid binding protein 4 (FABP4) is known to regulate both inflammation and lipid metabolism. In the present study, we elucidated the role of FABP4 using in vitro and in vivo models of preclampsia. We found increased expression of FABP4 in the placenta of preeclamptic rats, which was further confirmed in HTR-8 cells, an extravillous trophoblast cell line, treated with L-NAME. Overexpression of FABP4 in HTR-8 cells resulted in upregulated expression of pro-inflammatory cytokines IL-6 and TNF-α, and increased lipid accumulation, suggesting that FABP4 plays a role in preeclampsia...
October 2016: Placenta
https://www.readbyqxmd.com/read/26020659/-maternal-and-fetal-outcome-in-mexican-women-with-rheumatoid-arthritis
#2
Miguel A Saavedra, Antonio Sánchez, Reyna Bustamante, Dafhne Miranda-Hernández, Jimena Soliz-Antezana, Pilar Cruz-Domínguez, Sara Morales, Luis J Jara
OBJECTIVE: To report our experience in maternal-fetal outcome in women with RA in a national medical referral center. METHODS: A retrospective analysis of the records of pregnant women with rheumatoid arthritis attending at a Pregnancy and Autoimmune Rheumatic Diseases Clinic was performed. Maternal-fetal outcomes such as disease activity, preclampsia/eclampsia, rate of live births, abortions, stillbirths, preterm birth, weeks of gestation, birth weight, congenital malformations and use of anti-rheumatic drugs were studied...
2015: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/25787660/-308-pos-comparison-of-gene-expression-transcription-factors-stox1-storkhead-box-1-as-a-biomarker-of-preeclampsia
#3
Mukhamad Nooryanto
OBJECTIVES: Determine the usefulness and effectiveness of STOX1 in chromosome 10q22 as a biomarker of preeclampsia at an early stage. METHODS: This was a quantitative observational cross-sectional study of blood sample from pregnant women with preeclampsia (study group) and normotensive (control group) in the delivery room of Obstetrics and Gynecology Department Dr. Saiful Anwar Hospital Malang, and Physiology Laboratory Faculty of Medicine Brawijaya University during February to April 2013...
January 2015: Pregnancy Hypertension
https://www.readbyqxmd.com/read/23301457/study-of-intraventricular-hemorrhage-in-vlbw-neonates-admitted-in-al-zahra-hospital-tabriz-iran
#4
B Jodeiry, M Heidarzadeh, S Sahmani-Asl, M Hoseini, H Javaherizadeh, S Eliasi, K Abedini
INTRODUCTION AND AIM: Intra-ventricular hemorrhage (IVH) is an important predictor of adverse neurodevelopmental outcome. IVH risk factor identification may conduct improvement of quality of care in neonatal intensive care units. The aim of the current study was to determine possible risk factors associated with IVH in VLBW neonates admitted in our hospital. PATIENTS AND METHODS: All neonates with birth weight below 1500 gr admitted to NICU. Cranial ultrasonography was done for premature neonates weighed <1000 g in 3 to 5 days and in 1 month again...
January 2012: Nigerian Journal of Medicine: Journal of the National Association of Resident Doctors of Nigeria
https://www.readbyqxmd.com/read/23282257/-risk-factors-associated-to-preclampsia
#5
Mario Joaquín López-Carbajal, María Esther Manríquez-Moreno, Daniela Gálvez-Camargo, Evelia Ramírez-Jiménez
BACKGROUND: preeclampsia constitutes one of the main causes of maternal and perinatal morbidity and mortality. The aim was to identify the risk factors associated to the developmental of preeclampsia mild-moderate and severe, as well as the force of association of these factors in a hospital of second-level medical care. METHODOLOGY: study of cases and controls, a relation 1:1, in women withdrawn of the Service of Gynecology and Obstetrics during 2004 to 2007. Pregnant women with more than 20 weeks gestation were included...
September 2012: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/22676366/decreased-maternal-plasma-apelin-concentrations-in-preeclampsia
#6
Katherine D Bortoff, Chunfang Qiu, Scott Runyon, Michelle A Williams, Rangan Maitra
BACKGROUND: Preeclampsia is a hypertensive disorder that complicates 3-7% of pregnancies. The development of preeclampsia has not been completely elucidated and current therapies are not broadly efficacious. The apelinergic system appears to be involved in hypertensive disorders and experimental studies indicate a role of this system in preeclampsia. Thus, an epidemiological evaluation of apelin protein concentration in plasma was conducted in case-control study of pregnant women. METHODS: Data and maternal plasma samples were collected from pregnant women with confirmed preeclampsia (n = 76) or normotensive controls (n = 79)...
2012: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/22439080/biochemical-markers-for-prediction-of-preclampsia-review-of-the-literature
#7
Santo Monte
Preeclampsia (PE) is one of the most common diseases worldwide, complicating ~5% of all pregnancies.Although no major progress has been achieved in the treatment of PE, our ability to identify women at highrisk has increased considerably during the past decade.The early identification of patients with an increased risk for preeclampsia is therefore one of the most important goals in obstetrics. Today, several markers may offer the potential to be used, most likely in a combinatory analysis, as predictors or diagnostic tools...
July 2011: Journal of Prenatal Medicine
https://www.readbyqxmd.com/read/22264588/uteroplacental-arterio-venous-difference-in-soluble-vegfr-1-sflt-1-but-not-in-soluble-endoglin-concentrations-in-preeclampsia
#8
COMPARATIVE STUDY
M C Paasche Roland, B Lorentzen, K Godang, T Henriksen
The aim was to determine plasma levels of sFlt-1 and sEng on the arterial and venous side of the uteroplacental circulation in preeclamptic patients and healthy controls. Preeclamptic patients had higher arterial concentrations than controls of sFlt-1 (17,450 vs. 5055 pg/ml, p = 0.003) and sEng (68.7 vs. 28.7 ng/ml, p = 0.003). In the preclampsia group sFlt-1 was higher in the uterine vein than in the radial artery (22,450 vs. 17,450 pg/ml, p = 0.005). We found no gradient for sEng. Our results support the hypothesis that excess sFlt-1 at least partly originates in placenta, while excess sEng appears to have a different origin...
March 2012: Placenta
https://www.readbyqxmd.com/read/20209780/c-reactive-protein-marker-for-evaluation-of-systemic-inflammatory-response-in-preeclampsia
#9
D Mihu, N Costin, Carmen Mihaela Mihu, Ligia Daniela Blaga, Raluca Bogdana Pop
AIM: Determination by a high sensitivity technique of serum C-reactive protein (CRP), a sensitive marker of inflammation in women with preeclampsia compared to normal pregnancy and investigation of the relationship between CRP and the severity of the preeclamptic syndrome. MATERIAL AND METHOD: The study included 40 women with preeclampsia and 40 control subjects with normal pregnancies in the last trimester of pregnancy. The serum CRP concentration was determined using the universal high sensitivity immunoturbidimetric assay...
October 2008: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/19711832/doppler-flowmetry-in-preeclampsia
#10
REVIEW
J Zahumensky
UNLABELLED: The purpose of this study was to summarize the new published data on the Doppler flowmetry in preeclampsia. METHODS: We summarize the new published data on the Doppler flowmetry in uteroplacental, fetoplacental and fetal circulation in preeclampsia. The present review summarized the results of clinical research on the Doppler flowmetry in the screening of risk of preclampsia, in the diagnosis of preclampsia and in the fetal risk in preclampsia (Ref. 19)...
2009: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/19545685/pregnancy-in-renal-transplant-recipients
#11
T Bouattar, H Hakim, H Rhou, L Benamar, R Bayahia, N Ouzeddoun
OBJECTIVE: Renal transplantation with a well-functioning graft leads to a rapid restoration of endocrine and sexual functions. The aim of this study was to examine our experience with pregnancies among renal transplant patients, particularly with regard to their impact on graft function. PATIENTS AND METHODS: We analyzed 10 pregnancies in 7 renal transplant recipients for long-term graft outcomes in terms of clinical and biological data. RESULTS: The mean patient age was 28...
June 2009: Transplantation Proceedings
https://www.readbyqxmd.com/read/18830544/expectant-versus-aggressive-management-in-severe-preeclampsia-remote-from-term
#12
D S Sarsam, M Shamden, R Al Wazan
INTRODUCTION: Our study aims to compare neonatal and maternal outcomes between expectant (or conservative) and aggressive (or immediate) management in cases with severe preclampsia remote from term. METHODS: This is a comparative study conducted at Al-Batool Teaching Hospital in Mosul City, Iraq, from April 2003 to August 2004. A total of 74 singleton pregnancies complicated by severe preeclampsia with gestational age of 24-34 weeks were studied during this period...
September 2008: Singapore Medical Journal
https://www.readbyqxmd.com/read/18382699/study-of-plasma-adrenomedullin-level-in-normal-pregnancy-and-preclampsia
#13
Azza Abo Senna, Magda Zedan, Gamal E Abd el-Salam, Ashraf I el-Mashad
AIM: The aim of this study was to evaluate whether maternal circulating adrenomedullin (AM) values in patients with preeclampsia are different from those in normotensive pregnant women at different gestational ages. SUBJECTS AND METHODS: In a prospective clinical study, 90 women aged 17 to 40 years old, were divided into 4 main groups: group I (45 women): Normotensive pregnant women at first trimester (15 women), second trimester (15 women), and third trimester (15 women) of pregnancies...
2008: Medscape Journal of Medicine
https://www.readbyqxmd.com/read/18257209/-assessment-of-maternal-cerebral-blood-flow-in-patients-with-preeclampsia
#14
Vesna Mandić, Zeljko Miković, Milan Dukić, Mladenko Vasiljević, Dejan Filimonović, Mirjana Bogavac
INTRODUCTION: Systemic vasoconstriction in preeclamptic patients increases vascular resistance, and is manifested by increased arterial blood flow velocity. The aim of the study is to evaluate if there is a change of Doppler indices in maternal medial cerbral artery (MCA) in severe preeclampsia due to: 1) severity of clinical symptoms, 2) the begining of eclamptic attack and 3) the application of anticonvulsive therapy. MATERIAL AND METHODS: A prospective clinical study included 92 pregnant women, gestational age 28-36 weeks...
January 2005: Medicinski Pregled
https://www.readbyqxmd.com/read/18161411/massive-vulvar-edema-in-a-woman-with-preeclampsia-a-case-report
#15
Alexandros Daponte, Hara Skentou, Konstantinos D Dimopoulos, Athanasios Kallitsaris, Ioannis E Messinis
BACKGROUND: Massive vulvar edema in a woman with preeclampsia preceded the development of massive ascites and impending eclampsia. CASE: A 17-year-old preeclamptic, primiparous woman was admitted with preeclampsia and massive vulvar edema. Other causes were excluded. The vulvar edema increased as the blood pressure and ascites increased, and a severe headache developed. Cesarean section for increasing preclampsia was performed. In the puerperium, the blood pressure improved and vulvar edema resolved...
November 2007: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/17996636/obstetric-risks-for-women-with-epilepsy-during-pregnancy
#16
REVIEW
Peter W Kaplan, Errol R Norwitz, Elinor Ben-Menachem, Page B Pennell, Maurice Druzin, Julian N Robinson, Jacki C Gordon
Women with epilepsy (WWE) face particular challenges during their pregnancy. Among the several obstetric issues for which there is some concern and the need for further investigation are: the effects of seizures, epilepsy, and antiepileptic drugs on pregnancy outcome and, conversely, the effects of pregnancy and hormonal neurotransmitters on seizure control and antiepileptic drug metabolism. Obstetric concerns include preclampsia/eclampsia, preterm delivery, placental abruption, spontaneous abortion, stillbirth, and small-for-date babies in WWE whether or not they are taking antiepileptic drugs...
November 2007: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/17447360/eclampsia-a-5-years-retrospective-review-of-216-cases-managed-in-two-teaching-hospitals-in-addis-ababa
#17
Misganaw Abate, Zufan Lakew
OBJECTIVE: to measure the magnitude of eclampsia and its maternal and perinatal outcome. METHODS: A 5 years retrospective descriptive study was conducted on 216 eclamptic cases diagnosed, admitted and managed from October 1994 to September 1999 in the two teaching hospitals of Addis Ababa; namely Tikur Anbessa and St Paul's Hospitals. RESULTS: There were 257 mothers with eclampsia treated in the given period and 35741 deliveries making the incidence of eclampsia 7...
January 2006: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/16086547/comparison-of-referral-and-non-referral-hypertensive-disorders-during-pregnancy-an-analysis-of-271-consecutive-cases-at-a-tertiary-hospital
#18
COMPARATIVE STUDY
Ching-Ming Liu, Shuenn-Dyh Chang, Po-Jen Cheng
BACKGROUND: This retrospective cohort study analyzed the clinical manifestations in patients with preeclampsia and eclampsia, assessed the risk factors compared to the severity of hypertensive disorders on maternal and perinatal morbidity, and mortality between the referral and non-referral patients. METHODS: 271 pregnant women with preeclampsia and eclampsia were assessed (1993 to 1997). Chi-square analysis was used for the comparison of categorical variables, and the comparison of the two independent variables of proportions in estimation of confidence intervals and calculated odds ratio of the referral and non-referral groups...
May 2005: Chang Gung Medical Journal
https://www.readbyqxmd.com/read/15550880/-pregnancy-beyond-age-40-in-382-women-a-retrospective-study-in-reunion-island
#19
H Roman, P-Y Robillard, C Julien, E Kauffmann, A Laffitte, M Gabriele, L Marpeau, G Barau
OBJECTIVE: To examine obstetrical and neonatal outcomes among women age 40 years and older. MATERIAL AND METHODS: There was a retrospective study including 382 pregnant women at least 40 years of age and 7786 controls aged 20-34, stratified according to parity. Associations between maternal age and pregnancy outcomes were assessed using Pearson's chi(2) test, Fischer exact test, Student test or Mann and Whitney test, as appropriate. RESULTS: Maternal age 40 and over was associated with an increased risk for gestational diabetes (multiparas: OR 3...
November 2004: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/15449750/management-of-pre-eclampsia-eclampsia
#20
REVIEW
Mo Ababneh
Preclampsia/eclampsia affects only a small proportion of all pregnancies, yet it is associated with significant morbidity and mortality for mother and baby, with post partum resolution. The disorder is triggered by a placental pathology followed by a wide spectrum of maternal systemic response. However, there remains controversy in practically every aspect of the condition. A full understanding of the condition, its variable presentation allows the consulting anesthetist to optimize a plan for anesthetic management...
June 2004: Middle East Journal of Anesthesiology
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