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https://www.readbyqxmd.com/read/29152588/the-delivery-science-rapid-analysis-program-a-research-and-operational-partnership-at-kaiser-permanente-northern-california
#1
Julie A Schmittdiel, Rick Dlott, Joseph D Young, Michael B Rothmann, Wendy Dyer, Alyce S Adams
Introduction: Health care researchers and delivery system leaders share a common mission to improve health care quality and outcomes. However, differing timelines, incentives, and priorities are often a barrier to research and operational partnerships. In addition, few funding mechanisms exist to generate and solicit analytic questions that are of interest to both research and to operations within health care settings, and provide rapid results that can be used to improve practice and outcomes...
October 2017: Learn Health Syst
https://www.readbyqxmd.com/read/29147128/the-effect-of-educational-intervention-on-weight-loss-in-adolescents-with-overweight-and-obesity-application-of-the-theory-of-planned-behavior
#2
Seyed Saeed Mazloomy-Mahmoodabad, Zohreh Sadat Navabi, Alireza Ahmadi, Mohsen Askarishahi
BACKGROUND: The increased prevalence of overweight and obesity in children and adolescents is associated with type 2 diabetes, hypertension, dyslipidemia, and cardiovascular diseases. The theory of planned behavior (TPB) efficiently explains the ability of perceived behavioral control and possibly attitude to enhance the motivations of the obese people to lose weight. Our aim was to investigate the effect of TPB-based education on weight loss in obese and overweight adolescents. METHODS: In an interventional study, simple random sampling was used to select 86 overweight and obese adolescents aged 13-18 years in the pediatric clinic at the Isfahan Cardiovascular Research Institute...
July 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29145690/-visual-analysis-of-retinal-oct-data
#3
Martin Röhlig, Anselm Jünemann, Dagmar-Christiane Fischer, Ruby Kala Prakasam, Oliver Stachs, Heidrun Schumann
Optical coherence tomography (OCT) enables noninvasive high-resolution 3D imaging of the human retina, and thus plays a fundamental role in ophthalmology. Via OCT examination, even subtle retinal changes can be captured, which occur in very early stages of different diseases (e.g., glaucoma, diabetes mellitus, or age-related macular degeneration). Yet, analyzing the resulting data is challenging. Conventionally, OCT data are strongly aggregated via automated methods. While this reduces the amount of information to be analyzed, it also makes it difficult, if not impossible, to identify small and localized retinal changes...
November 16, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29144963/translation-and-validation-of-pediatric-quality-of-life-inventory%C3%A2-3-0-diabetes-module-pedsql%C3%A2-3-0-diabetes-module-in-brazil-portuguese-language
#4
Leila F Dos S Garcia, Thais Della Manna, Caroline de Gouveia Buff Passone, Lygia Spassapan de Oliveira
OBJECTIVE: The aim of the present study was to create a translated version of the Pediatric Quality of Life Inventory™ 3.0 Diabetes Module (PedsQL™ 3.0 Diabetes Module) in Brazilian Portuguese that was conceptually equivalent to the original American English version and to linguistically validate it in a Brazilian pediatric population with type 1 diabetes mellitus and their parents or caregivers. METHODS: The instrument was translated, back-translated, and then administered to 83 children/adolescents (5-18 years) with type 1 diabetes mellitus and their family members and to 25 parents/caregivers of patients aged between 2 and 4 years...
November 13, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29136611/gut-microbiota-in-health-and-disease
#5
Yuichiro Yamashiro
Intestinal regulatory T (Treg) cells are critical to maintaining immune tolerance to dietary antigens and gut microbiota. This paper reviews several papers on this topic that were recently published by Japanese researchers. Specifically, Prof. K. Honda and his group have found that commensal microbiota capable of metabolizing butyrate induces the differentiation of colonic Treg cells. In a separate work, Prof. Y. Yokoyama and his group used a novel, culture-independent analytical method (the Yakult Intestinal Flora-Scan) for detection of bacteria in the bloodstream...
November 14, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29131017/initial-presentation-of-type-2-diabetes-in-adolescents-predicts-durability-of-successful-treatment-with-metformin-monotherapy-insights-from-the-pediatric-diabetes-consortium-t2d-registry
#6
Fida Bacha, Peiyao Cheng, Robin L Gal, Craig Kollman, William V Tamborlane, Georgeanna J Klingensmith, Katherine Manseau, Jamie Wood, Roy W Beck
BACKGROUND/AIMS: Many adolescents with type 2 diabetes (T2D) have rapid deterioration of glycemic control on metformin monotherapy within 2 years of diagnosis. METHODS: Enrollment data from the Pediatric Diabetes Consortium T2D Registry were used to categorize 276 youth with a T2D duration ≥2 years into two groups: (1) participants with HbA1c <7.5% on metformin monotherapy (group 1, n = 75) and (2) participants treated with insulin ± metformin (group 2, n = 201)...
October 31, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29130034/the-effects-of-disease-related-symptoms-on-daily-function-in-wolfram-syndrome
#7
Tasha Doty, Erin R Foster, Bess Marshall, Samantha Ranck, Tamara Hershey
OBJECTIVE: To investigate daily function among individuals with Wolfram Syndrome (WFS) and examine whether any limitations are related to disease-related symptoms. METHODS: WFS (n = 31), Type 1 diabetic (T1DM; n = 25), and healthy control (HC; n = 29) participants completed the Pediatric Quality of Life Questionnaire (PEDSQL) Self and Parent Report. PEDSQL domain scores were compared among these groups and between WFS patients with and without specific disease-related symptoms...
2017: Translational Science of Rare Diseases
https://www.readbyqxmd.com/read/29125655/25-hydroxyvitamin-d-autoantigenic-and-total-antibody-concentrations-results-from-a-danish-case-control-study-of-newly-diagnosed-patients-with-childhood-type-1-diabetes-and-their-healthy-siblings
#8
Steffen Ullitz Thorsen, Christian B Pipper, Jesper Johannesen, Henrik Bindesbøl Mortensen, Flemming Pociot, Jannet Svensson
BACKGROUND: B cells have recently entered the stage as an important accessory player in type 1 diabetes (T1D) etiopathogenesis. Experimental studies suggest regulatory functions of vitamin D on B cells. However, only a few human studies, with considerable methodological limitations, have been conducted within this field. OBJECTIVE: Our objective was to investigate if higher 25-hydroxyvitamin D (25(OH)D) concentrations were inversely associated with β-cell autoantigens glutamic acid decarboxylase (isoform 65) (GADA) and insulinoma associated antigen-2A (IA-2A)...
November 10, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29125446/suprasellar-and-recurrent-pediatric-craniopharyngiomas-expanding-indications-for-the-extended-endoscopic-transsphenoidal-approach
#9
Andrew F Alalade, Elizabeth Ogando-Rivas, Jerome Boatey, Mark M Souweidane, Vijay K Anand, Jeffrey P Greenfield, Theodore H Schwartz
OBJECTIVE The expanded endonasal endoscopic transsphenoidal approach has become increasingly used for craniopharyngioma surgery in the pediatric population, but questions still persist regarding its utility in younger children, in recurrent and irradiated tumors, and in masses primarily located in the suprasellar region. The narrow corridor, incomplete pneumatization, and fear of hypothalamic injury have traditionally relegated this approach to application in older children with mostly cystic craniopharyngiomas centered in the sella...
November 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29117624/the-role-of-lipids-in-the-pathogenesis-of-metabolic-syndrome-in-adolescents
#10
Shahnaz Taghizadeh, Mohammad Alizadeh
The increasing prevalence of childhood obesity is a driving force behind the increase in adolescent's metabolic syndrome (MetS). Although there is no clear consensus about the pediatric definition for MetS, this syndrome is becoming very common among adolescents. It is characterized by insulin resistance (IR), dyslipidemia, abdominal obesity and hypertension, and is associated with a high risk of type 2 diabetes mellitus and CVD in adulthood. Due to the increasing prevalence of obesity, there is strong incentive to reduce the impact of the adverse health effects associated with MetS...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29115018/relationship-between-exercise-capacity-and-glucose-tolerance-in-cystic-fibrosis
#11
Karla Foster, Guixia Huang, Nanhua Zhang, Joseph Crisalli, Barbara Chini, Raouf Amin, Deborah Elder
BACKGROUND: Improved exercise capacity (EC) and normal glucose tolerance (NGT) are independently associated with favorable outcomes in CF, however, little information on this relationship exists in patients with CF. METHODS: Cardiopulmonary exercise tests, oral glucose tolerance tests (OGTT), and HbA1c values measured within a 12-month period were evaluated on 83 pediatric patients diagnosed with CF. Patients were categorized as having NGT, abnormal glucose tolerance (AGT), or CF-related diabetes (CFRD)...
November 8, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29111277/resolution-of-ketoacidosis-in-children-with-new-onset-diabetes-evaluation-of-various-definitions
#12
Julia E von Oettingen, Erinn T Rhodes, Joseph I Wolfsdorf
AIMS: Data are sparse concerning use of serum electrolyte parameters as compared to venous blood gas (VBG) measurements to monitor acid-base status during treatment of diabetic ketoacidosis (DKA). We explored the utility of various parameters to define DKA resolution by investigating the relationship of venous pH (vpH), anion gap (AG), serum bicarbonate (HCO3), and glucose concentration during management of DKA in children with new onset diabetes mellitus (NODM). METHODS: We included all patients with NODM presenting with DKA to Boston Children's Hospital from 10/1/07-7/1/13...
October 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29111083/postoperative-outcomes-in-vedolizumab-treated-pediatric-patients-undergoing-abdominal-operations-for-inflammatory-bowel-disease
#13
Amy L Lightner, Chung Sang Tse, D Dean Potter, Christopher Moir
INTRODUCTION: Recent studies have found vedolizumab to be an independent predictor of increased rates of postoperative complications and surgical site infections (SSIs) in adults with inflammatory bowel disease (IBD), but studies in the pediatric surgical population are lacking. We sought to determine the 30-day postoperative infectious complication rate among pediatric IBD patients who received vedolizumab within 12weeks of a major abdominal operation. METHODS: A retrospective chart review was performed on pediatric IBD patients who underwent an abdominal operation between 5/20/2014 and 6/1/2017...
October 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29107758/exploring-correlates-of-diabetes-related-stress-among-adults-with-type-1-diabetes-in-the-t1d-exchange-clinic-registry
#14
Matthew Tyler Boden, Sasha Gala
AIMS: To explore relations between diabetes-related stress and multiple sociodemographic, diabetes health, other health, and treatment-related variables among a large, diverse sample of adults with Type 1 Diabetes (T1D). METHODS: The sample consisted of 10,821 adults (over 18 years old) enrolled in the T1D Exchange Clinic Registry. The T1D Exchange clinic network consists of 67 diabetes clinical centers throughout the United States selected to broadly represent pediatric and adult patients with T1D...
October 28, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29106615/measuring-self-efficacy-in-the-context-of-pediatric-diabetes-management-psychometric-properties-of-the-self-efficacy-for-diabetes-scale
#15
Jason Van Allen, Amy E Noser, Andrew K Littlefield, Paige L Seegan, Mark Clements, Susana R Patton
The Self-Efficacy for Diabetes Scale (SED) is a widely used measure of diabetes-specific self-efficacy with three subscales: diabetes-specific self-efficacy (SED-D), medical self-efficacy (SED-M), and general self-efficacy (SED-G). The present study examined the factor structure and construct validity of the SED in 116 youth, aged 10-16 years (13.60 ± 1.87), with type 1 diabetes mellitus. Confirmatory factor analysis (CFA) was used to examine the factor structure of the SED. Correlational and regression analyses examined relations between subscales and select outcomes...
July 4, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29099514/clinical-inquiries-what-is-the-optimal-frequency-for-dental-checkups-for-children-and-adults
#16
Thomas W Hahn, Connie Kraus, Christopher Hooper-Lane
IT IS UNCLEAR, but studies suggest that it should be based largely on individual risk. The American Academy of Pediatric Dentistry recommends a 6-month interval for preventive dental visits (strength of recommendation [SOR]: C, expert opinion), but a 24-month interval does not result in an increased incidence of dental caries in healthy children and young adults or increased incidence of gingivitis in healthy adults (SOR: B, a single randomized controlled trial [RCT]). In adults with risk factors (eg, smoking or diabetes), visits at 6-month intervals are associated with a lower incidence of tooth loss (SOR: C, a retrospective cohort study)...
November 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/29098067/radiographic-and-magnetic-resonances-contrast-agents-essentials-and-tips-for-safe-practices
#17
REVIEW
Mohamed R Nouh, Mohamed A El-Shazly
With extended and continued expansion of medical imaging utilization in modern medical practice over last decade, radiologists as well as other faculty staff dealing with radiographic and magnetic resonances contrast media (CM) have to be well oriented with their potential hypersensitivity reactions and recognize high-risk groups liable to develop it and enable early recognition. Radiologists and other medical staff involved in administration and dealing with CM have to be ready to implement prompt, practical and effective management plan to deal with these scenarios should they emerge...
September 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/29094435/the-burden-of-common-infections-in-children-and-adolescents-with-diabetes-mellitus-a-pediatric-health-information-system-study
#18
Lindsey Korbel, Robert S Easterling, Nidhi Punja, John David Spencer
BACKGROUND: People with diabetes mellitus (DM) have increased infection risk. The healthcare utilization of pediatric and adolescent diabetic patients with infection is not well defined. This study evaluates the number of pediatric and adolescent patients with DM that seek medical treatment for infection management and assesses its socioeconomic impact. METHODS: A retrospective analysis was performed using the Pediatric Health Information System (PHIS) database on children and adolescents with DM who presented to the Emergency Department (ED) or were hospitalized for infection management from 2008 to 2014...
November 2, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29092051/the-role-of-age-and-excess-body-mass-index-in-progression-to-type-1-diabetes-in-at-risk-adults
#19
Christine T Ferrara, Susan Geyer, Carmella Evans-Molina, Ingrid Libman, Dorothy Becker, John M Wentworth, Antoinette Moran, Stephen Gitelman, Maria J Redondo
Background: Given the global rise in both type 1 diabetes incidence and obesity, the role of BMI on type 1 diabetes pathophysiology has gained great interest. Sustained excess BMI in pediatric participants of the TrialNet Pathway to Prevention cohort (PTP) increased risk of progression to type 1 diabetes, but the effects of age and obesity in adults remain largely unknown. Objective: To determine the effect of age and sustained obesity on the risk of type 1 diabetes in adult participants in the TrialNet PTP cohort, i...
October 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29090036/the-autoimmunity-s-footprint-in-pediatrics-type-1-diabetes-coeliac-disease-thyroiditis
#20
Anca Orzan, Carmen Novac, Mihaela Mihu, Constantin Ionescu Tirgoviste, Mihaela Balgradean
The present case report aims to describe and discuss the approach for the management of difficult endotracheal intubation in an adult with Down syndrome undergoing cataract surgery. A 26-year-old female with Down syndrome and a validated diagnosis of cataract requiring surgery was examined in order to assess the degree of difficulty of endotracheal intubation. Patients with Down syndrome have characteristic craniofacial abnormalities which require a thorough pre-operative assessment to anticipate and prepare for a difficult endotracheal intubation...
June 2017: Mædica
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