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https://www.readbyqxmd.com/read/29140819/positive-and-negative-impacts-of-a-continuing-professional-development-intervention-on-pharmacist-practice-a-balanced-measure-evaluation
#1
Sukhjinder Sidhu, Sean K Gorman, Richard S Slavik, Tasha Ramsey, Nicole Bruchet, Sarah Murray
INTRODUCTION: Evaluations of behavior change interventions aimed at improving professional practice are increasingly focused on impacts at the practice and patient outcome levels. Many of these evaluations assume that if the intended changes occur, the result represents an improvement. However, given the systemic nature of clinical practice, a change in one area can produce changes in other areas as well, some of which may adversely affect the patient. Balancing measures are used to determine whether unintended consequences of an intervention have been introduced into other areas of the system...
November 14, 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/29128118/associations-between-inflammatory-markers-and-cognitive-function-in-breast-cancer-patients-receiving-chemotherapy
#2
AnnaLynn M Williams, Raven Shah, Michelle Shayne, Alissa J Huston, Marcia Krebs, Nicole Murray, Bryan D Thompson, Kassandra Doyle, Jenna Korotkin, Edwin van Wijngaarden, Sharon Hyland, Jan A Moynihan, Deborah A Cory-Slechta, Michelle C Janelsins
BACKGROUND: Cancer-related cognitive impairment (CRCI) is often related to chemotherapy. Increased chronic inflammation is believed to play a key role in the development of CRCI related to chemotherapy but studies assessing this hypothesis specifically in patients receiving chemotherapy are rare. METHODS: We assessed several cognitive domains using the Cambridge Neuropsychological Test Automated Battery (CANTAB) in twenty-two breast cancer patients currently receiving chemotherapy...
October 18, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29126824/video-intervention-to-increase-perceived-self-efficacy-for-condom-use-in-a-randomized-controlled-trial-of-female-adolescents
#3
Julie S Downs, Amie M Ashcraft, Pamela J Murray, Elise D Berlan, Wändi Bruine de Bruin, Joan Eichner, Baruch Fischhoff, Janie A Leary, Robert B McCall, Elizabeth Miller, Jennifer Salaway, Janell Smith-Jones, Gina S Sucato
STUDY OBJECTIVE: To assess the effects of the Seventeen Days interactive video on young women's perceived self-efficacy for using condoms six months after being offered the intervention, relative to a control. DESIGN: Multisite randomized controlled trial SETTING: Twenty participating health clinics and county health departments in Ohio, Pennsylvania, and West Virginia PARTICIPANTS: Sexually active females ages 14 to 19 INTERVENTIONS: Seventeen Days (treatment intervention; sex education) versus Driving Skills for Life (control intervention; driving education) MAIN OUTCOME MEASURES: Perceived self-efficacy for condom use RESULTS AND CONCLUSIONS: Participants in the Seventeen Days group reported higher perceived condom acquisition self-efficacy after six months than those in the driving group...
November 7, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29124901/raccoon-roundworm-baylisascaris-procyonis-as-an-occupational-hazard-1-knowledge-of-b-%C3%A2-procyonis-and-attitudes-towards-it-and-other-zoonoses-among-wildlife-rehabilitators
#4
S G H Sapp, B A Murray, E R Hoover, G T Green, M J Yabsley
Wildlife rehabilitators are at risk of zoonotic diseases because they often have prolonged contact with many species of wildlife and their bodily fluids. Raccoon roundworm (Baylisascaris procyonis) is a common zoonotic parasite of raccoons that has the potential to cause severe or fatal neurologic disease in a broad variety of hosts if the eggs within raccoon faeces are ingested. We administered an online survey to wildlife rehabilitators to assess their knowledge regarding aspects of transmission, biology and disease caused by B...
November 10, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29117909/a-history-of-obstetric-complications-is-associated-with-the-risk-of-progression-from-an-at-risk-mental-state-to-psychosis
#5
Magdalena Kotlicka-Antczak, Agnieszka Pawełczyk, Tomasz Pawełczyk, Dominik Strzelecki, Natalia Żurner, Michał Seweryn Karbownik
OBJECTIVE: Clinical criteria for diagnosing Clinical High Risk for psychosis are now available. However, an understanding of the factors modulating the risk of subsequent development of frank psychosis in "at risk" individuals remains elusive. The aim of the study was to identify associations between obstetric history and the development of psychotic disorders in individuals with an At Risk Mental State (ARMS). METHODS: Obstetric data was obtained from the medical records of 82 individuals meeting ARMS criteria...
November 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29117060/cognitive-development-1-year-after-infantile-critical-pertussis
#6
John T Berger, Michele E Villalobos, Amy E Clark, Richard Holubkov, Murray M Pollack, Robert A Berg, Joseph A Carcillo, Heidi Dalton, Rick Harrison, Kathleen L Meert, Christopher J L Newth, Thomas P Shanley, David L Wessel, Kanwaljeet J S Anand, Jerry J Zimmerman, Ronald C Sanders, Teresa Liu, Jeri S Burr, Douglas F Willson, Allan Doctor, J Michael Dean, Tammara L Jenkins, Carol E Nicholson
OBJECTIVES: Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. DESIGN: Prospective cohort study. SETTING: Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States...
November 7, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29116126/development-of-multivariable-models-to-predict-change-in-body-mass-index-within-a-clinical-trial-population-of-psychotic-individuals
#7
Rebecca N S Harrison, Fiona Gaughran, Robin M Murray, Sang Hyuck Lee, Jose Paya Cano, David Dempster, Charles J Curtis, Danai Dima, Hamel Patel, Simone de Jong, Gerome Breen
Many antipsychotics promote weight gain, which can lead to non-compliance and relapse of psychosis. By developing models that accurately identify individuals at greater risk of weight gain, clinicians can make informed treatment decisions and target intervention measures. We examined clinical, genetic and expression data for 284 individuals with psychosis derived from a previously published randomised controlled trial (IMPACT). These data were used to develop regression and classification models predicting change in Body Mass Index (BMI) over one year...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29105977/tau-pet-imaging-predicts-cognition-in-atypical-variants-of-alzheimer-s-disease
#8
Jeffrey S Phillips, Sandhitsu R Das, Corey T McMillan, David J Irwin, Emily E Roll, Fulvio Da Re, Ilya M Nasrallah, David A Wolk, Murray Grossman
Accumulation of paired helical filament tau contributes to neurodegeneration in Alzheimer's disease (AD). (18) F-flortaucipir is a positron emission tomography (PET) radioligand sensitive to tau in AD, but its clinical utility will depend in part on its ability to predict cognitive symptoms in diverse dementia phenotypes associated with selective, regional uptake. We examined associations between (18) F-flortaucipir and cognition in 14 mildly-impaired patients (12 with cerebrospinal fluid analytes consistent with AD pathology) who had amnestic (n = 5) and non-amnestic AD syndromes, including posterior cortical atrophy (PCA, n = 5) and logopenic-variant primary progressive aphasia (lvPPA, n = 4)...
November 6, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29095544/predictive-validity-and-correlates-of-self-assessed-resilience-among-u-s-army-soldiers
#9
Laura Campbell-Sills, Ronald C Kessler, Robert J Ursano, Xiaoying Sun, Charles T Taylor, Steven G Heeringa, Matthew K Nock, Nancy A Sampson, Sonia Jain, Murray B Stein
BACKGROUND: Self-assessment of resilience could prove valuable to military and other organizations whose personnel confront foreseen stressors. We evaluated the validity of self-assessed resilience among U.S. Army soldiers, including whether predeployment perceived resilience predicted postdeployment emotional disorder. METHODS: Resilience was assessed via self-administered questionnaire among new soldiers reporting for basic training (N = 35,807) and experienced soldiers preparing to deploy to Afghanistan (N = 8,558)...
November 2, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29094770/an-oral-epidemiological-comparison-of-chinese-and-new-zealand-adults-in-2-key-age-groups
#10
Songlin He, William Murray Thomson
OBJECTIVES: To use recent national survey data to compare dentition status and oral diseases in China and New Zealand (NZ), with a particular focus on differences by sex and education level. METHODS: We undertook secondary analysis of representative data from oral health surveys conducted in 2009 in Sichuan (China) and NZ. Both surveys had an oral examination component and collected detailed demographic data. Socioeconomic position in this analysis was represented by the highest level of education completed...
November 2, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29092024/characterization-of-male-breast-cancer-results-of-the-eortc-10085-tbcrc-big-nabcg-international-male-breast-cancer-program
#11
F Cardoso, J M S Bartlett, L Slaets, C H M van Deurzen, E van Leeuwen-Stok, P Porter, B Linderholm, I Hedenfalk, C Schröder, J Martens, J Bayani, C van Asperen, M Murray, C Hudis, L Middleton, J Vermeij, K Punie, J Fraser, M Nowaczyk, I T Rubio, S Aebi, C Kelly, K J Ruddy, E Winer, C Nilsson, L Dal Lago, L Korde, K Benstead, O Bogler, T Goulioti, A Peric, S Litière, K C Aalders, C Poncet, K Tryfonidis, S H Giordano
Background: Male breast cancer (BC) is rare, managed by extrapolation from female BC. The International Male BC Program aims to better characterize and manage this disease. We report the results of part 1, a retrospective-joint-analysis of cases diagnosed during a 20-year-period. Methods: Patients with follow-up and tumor samples, treated between 1990-2010, in 93 centers/nine countries. Samples were centrally analyzed in three labs (UK, NL, US). Results: Of 1822 patients enrolled, 1483 were analyzed; 63...
October 28, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29083292/collaborative-care-transitions-symposium-insights-from-participants
#12
Lianne Jeffs, Marianne Saragosa, Michelle Zahradnik, Maria Maione, Aimee Hindle, Cecilia Santiago, Murray Krock, Vicky Stergiopoulos, Beverly Bulmer, Kaleil Mitchell, Colleen McNamee, Noor Ramji
BACKGROUND/PURPOSE: There are promising signs that interprofessional collaborative practice is associated with quality care transitions and improved access to patient-centred healthcare. A one-day symposium was held to increase awareness and capacity to deliver quality collaborative care transitions to interprofessional health disciplines and service users. METHOD: A mixed methods study was used that included a pre-post survey design and interviews to examine the impact of the symposium on knowledge, attitudes and practice change towards care transitions and collaborative practice with symposium participants...
2017: Nursing Leadership
https://www.readbyqxmd.com/read/29077900/patient-acceptable-symptom-state-in-scleroderma-results-from-the-tocilizumab-compared-with-placebo-trial-in-active-diffuse-cutaneous-systemic-sclerosis
#13
Michael B Arnold, Dinesh Khanna, Christopher P Denton, Jacob M van Laar, Tracy M Frech, Marina E Anderson, Murray Baron, Lorinda Chung, Gerhard Fierlbeck, Santhanam Lakshminarayanan, Yannick Allanore, Gabriela Riemekasten, Virginia Steen, Ulf Müller-Ladner, Helen Spotswood, Laura Burke, Jeffrey Siegel, Angelika Jahreis, Daniel E Furst, Janet E Pope
Objectives: Patient acceptable symptom state (PASS) as an absolute state of well-being has shown promise as an outcome measure in many rheumatologic conditions. We aimed to assess whether PASS may be effective in active diffuse cutaneous SSc differentiating active from placebo. Methods: Data from the phase 2 Safety and Efficacy of Subcutaneous Tocilizumab in Adults with Systemic Sclerosis (faSScinate) trial were used, which compared tocilizumab (TCZ) vs placebo over 48 weeks followed by an open-label TCZ period to 96 weeks...
October 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/29076127/the-applicability-of-dental-wear-in-age-estimation-for-a-modern-american-population
#14
Katie E Faillace, Jonathan D Bethard, Murray K Marks
OBJECTIVES: Though applied in bioarchaeology, dental wear is an underexplored age indicator in the biological anthropology of contemporary populations, although research has been conducted on dental attrition in forensic contexts (Kim et al., , Journal of Forensic Sciences, 45, 303; Prince et al., , Journal of Forensic Sciences, 53, 588; Yun et al., , Journal of Forensic Sciences, 52, 678). The purpose of this study is to apply and adapt existing techniques for age estimation based on dental wear to a modern American population, with the aim of producing accurate age range estimates for individuals from an industrialized context...
October 27, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29074153/is-repeat-pulmonary-metastasectomy-indicated-for-soft-tissue-sarcoma
#15
Neel P Chudgar, Murray F Brennan, Kay See Tan, Rodrigo R Munhoz, Sandra P D'Angelo, Manjit S Bains, James Huang, Bernard J Park, Prasad S Adusumilli, William D Tap, David R Jones
BACKGROUND: Because recurrence is high after pulmonary metastasectomy (PM) for soft tissue sarcoma (STS), repeat PM is commonly performed. Our objective was to define the selection criteria for repeat PM among patients experiencing recurrence and to identify factors associated with survival. METHODS: We reviewed a prospectively maintained database of 539 patients undergoing PM for STS. Characteristics of the primary tumor, metastatic disease, treatment, and recurrence were examined...
October 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29073953/temporary-circulatory-support-in-u-s-children-awaiting-heart-transplantation
#16
Vamsi V Yarlagadda, Katsuhide Maeda, Yulin Zhang, Sharon Chen, John C Dykes, Mary Alice Gowen, Paul Shuttleworth, Jenna M Murray, Andrew Y Shin, Olaf Reinhartz, David N Rosenthal, Doff B McElhinney, Christopher S Almond
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) has long served as the standard of care for short-term mechanical circulatory support in pediatrics. It is unknown whether newer-generation temporary circulatory support (TCS) devices afford children a meaningful survival advantage over ECMO. OBJECTIVES: This study sought to determine whether bridge-to-heart transplant survival with a TCS device is superior to ECMO after adjusting for patient differences. METHODS: All children ≤21 years of age listed for heart transplant from 2011 to 2015 who received a TCS device or ECMO as a bridge to transplant were identified using Organ Procurement and Transplantation Network data...
October 31, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29071048/changes-in-antimicrobial-prescribing-behavior-after-the-introduction-of-the-antimicrobial-stewardship-program-a-pre-and-post-intervention-survey
#17
Ruchir Chavada, Harry N Walker, Deborah Tong, Amy Murray
The introduction of an antimicrobial stewardship (AMS) program is associated with a change in antimicrobial prescribing behavior. A proposed mechanism for this change is by impacting the prescribing etiquette described in qualitative studies. This study sought to detect a change in prescribing attitudes 12 months after the introduction of AMS and gauge utility of various AMS interventions. Surveys were distributed to doctors in two regional Australian hospitals on a convenience basis 6 months before, and 12 months after, the introduction of AMS...
October 2, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/29066610/high-sensitivity-cardiac-troponin-i-and-risk-of-cardiovascular-disease-in-an-australian-population-based-cohort
#18
Kun Zhu, Matthew Knuiman, Mark Divitini, Kevin Murray, Ee Mun Lim, Andrew St John, John P Walsh, Joseph Hung
OBJECTIVE: High-sensitivity cardiac troponin I (hs-cTnI) is an emerging biomarker for cardiovascular risk. We examined hs-cTnI as a predictor of mortality and cardiovascular outcomes in an Australian population-based cohort and evaluated if a sex difference exists. METHODS: Serum hs-cTnI was measured in the Busselton Health Study 1994/1995 Cohort (n=3939). Outcome measures were total and cardiovascular mortality, cardiovascular disease (CVD) and coronary heart disease (CHD) events, heart failure and stroke...
October 24, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29066464/safety-and-efficacy-of-subcutaneous-tocilizumab-in-systemic-sclerosis-results-from-the-open-label-period-of-a-phase-ii-randomised-controlled-trial-fasscinate
#19
Dinesh Khanna, Christopher P Denton, Celia Jf Lin, Jacob M van Laar, Tracy M Frech, Marina E Anderson, Murray Baron, Lorinda Chung, Gerhard Fierlbeck, Santhanam Lakshminarayanan, Yannick Allanore, Janet E Pope, Gabriela Riemekasten, Virginia Steen, Ulf Müller-Ladner, Helen Spotswood, Laura Burke, Jeffrey Siegel, Angelika Jahreis, Daniel E Furst
OBJECTIVES: Assess the efficacy and safety of tocilizumab in patients with systemic sclerosis (SSc) in a phase II study. METHODS: Patients with SSc were treated for 48 weeks in an open-label extension phase of the faSScinate study with weekly 162 mg subcutaneous tocilizumab. Exploratory end points included modified Rodnan Skin Score (mRSS) and per cent predicted forced vital capacity (%pFVC) through week 96. RESULTS: Overall, 24/44 (55%) placebo-tocilizumab and 27/43 (63%) continuous-tocilizumab patients completed week 96...
October 24, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29065753/perioperative-adjuvant-corticosteroids-for-postoperative-analgesia-in-knee-arthroplasty
#20
Hasan R Mohammad, Thomas W Hamilton, Louise Strickland, Marialena Trivella, David Murray, Hemant Pandit
Background and purpose - Immediate postoperative pain management offered in knee arthroplasty is suboptimal in up to one-third of patients resulting in high opiate consumption and delayed discharge. In this meta-analysis we investigate the analgesic effect and safety of perioperative adjuvant corticosteroids in knee arthroplasty. Methods - Databases Medline, Embase, and Central were searched for randomized studies comparing the analgesic effect of adjuvant perioperative corticosteroids in knee arthroplasty...
October 25, 2017: Acta Orthopaedica
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