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https://www.readbyqxmd.com/read/28329301/association-between-non-iron-deficient-anemia-and-insomnia-symptoms-in-community-dwelling-older-adults-the-baltimore-longitudinal-study-of-aging
#1
Lenis P Chen-Edinboro, Laura E Murray-Kolb, Eleanor M Simonsick, Luigi Ferrucci, Richard Allen, Martha E Payne, Adam P Spira
Background: Anemia is associated with poorer sleep in children, and clinically, anemia is linked to insomnia. However, the association between anemia and insomnia in older adults is understudied. Methods: We examined the cross-sectional association between anemia and insomnia in 1,053 adults (71.4 ± 10.6 years) in the Baltimore Longitudinal Study of Aging. Participants were classified as nonanemic, non-iron-deficient anemic, or iron-deficient anemic based on hemoglobin, ferritin, transferrin saturation, and mean cell volume...
January 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329254/periodic-limb-movements-and-white-matter-hyperintensities-in-first-ever-minor-stroke-or-high-risk-tia
#2
Mark I Boulos, Brian J Murray, Ryan T Muir, Fuqiang Gao, Gregory M Szilagyi, Menal Huroy, Alexander Kiss, Arthur S Walters, Sandra E Black, Andrew S Lim, Richard H Swartz
Study Objectives: Emerging evidence suggests that periodic limb movements (PLMs) may contribute to the development of cerebrovascular disease. White matter hyperintensities (WMHs), a widely accepted biomarker for cerebral small vessel disease, are associated with incident stroke and death. We evaluated the association between increased PLM indices and WMH burden in patients presenting with stroke or transient ischemic attack (TIA), while controlling for vascular risk factors and stroke severity...
December 29, 2016: Sleep
https://www.readbyqxmd.com/read/28326612/serum-phosphate-and-cognitive-function-in-older-men
#3
Yelena Slinin, Tien Vo, Brent C Taylor, Anne M Murray, John Schousboe, Lisa Langsetmo, Kristine Ensrud
OBJECTIVE: Determine whether serum phosphate is associated with concurrent cognitive impairment and subsequent cognitive decline in older men independent of demographic covariates and atherosclerotic risk factors. METHODS: In a prospective study of 5529 men enrolled in the Osteoporotic Fractures in Men study, we measured baseline serum phosphate, baseline cognitive function, and change in cognitive function between baseline and follow-up exams an average of 4.6 years later using the Modified Mini-Mental State (3MS) Examination and Trails B...
March 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28324918/statistical-consequences-of-a-successful-lung-allocation-system-recovering-information-and-reducing-bias-in-models-for-urgency
#4
Nabihah Tayob, Susan Murray
The lung allocation system has reduced the number of waitlist deaths by ranking transplant candidates on the basis of a lung allocation score that requires estimation of the current 1-year restricted mean waitlist survival (urgency). Fewer waitlist deaths and the systematic removal of candidates from the waitlist for transplantation present statistical challenges that must be addressed when using recent waitlist data. Multiple overlapping 1-year follow-up windows are used in a restricted mean model that estimates patient urgency on the basis of updated risk factors at the start of the window...
March 21, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28323466/sexual-assault-victimization-and-mental-health-treatment-suicide-attempts-and-career-outcomes-among-women-in-the-us-army
#5
Anthony J Rosellini, Amy E Street, Robert J Ursano, Wai Tat Chiu, Steven G Heeringa, John Monahan, James A Naifeh, Maria V Petukhova, Ben Y Reis, Nancy A Sampson, Paul D Bliese, Murray B Stein, Alan M Zaslavsky, Ronald C Kessler
OBJECTIVES: To examine associations of administratively recorded sexual assault victimization during military service with subsequent mental health and negative career outcomes among US Army women controlling for nonrandom victimization exposure. METHODS: We used data from the Army Study to Assess Risk and Resilience in Servicemembers to apply propensity score methods to match all 4238 female Regular Army soldiers with administratively recorded sexual assault victimization during 2004 to 2009 to 5 controls per case with similar composite victimization risk...
March 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28316090/impaired-quality-of-life-in-patients-with-treated-acromegaly-despite-long-term-biochemically-stable-disease-results-from-a-5-year-prospective-study
#6
Nikolaos Kyriakakis, Julie Lynch, Stephen G Gilbey, Susan M Webb, Robert D Murray
OBJECTIVE: Patients with acromegaly demonstrate impaired quality of life (QoL), but data on long-term QoL changes in treated acromegaly are limited. This study evaluates and identifies factors that influence QoL in patients with long-term biochemical remission. DESIGN: The study consists of a cross-sectional arm comparing QoL between patients with treated and controlled acromegaly and healthy controls; and a longitudinal arm assessing QoL changes in patients with biochemically stable disease during 5...
March 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28302634/residential-proximity-to-major-roads-exposure-to-fine-particulate-matter-and-aortic-calcium-the-framingham-heart-study-a-cohort-study
#7
Kirsten S Dorans, Elissa H Wilker, Wenyuan Li, Mary B Rice, Petter L Ljungman, Joel Schwartz, Brent A Coull, Itai Kloog, Petros Koutrakis, Ralph B D'Agostino, Joseph M Massaro, Udo Hoffmann, Christopher J O'Donnell, Murray A Mittleman
OBJECTIVES: Traffic and ambient air pollution exposure are positively associated with cardiovascular disease, potentially through atherosclerosis promotion. Few studies have assessed associations of these exposures with thoracic aortic calcium Agatston score (TAC) or abdominal aortic calcium Agatston score (AAC), systemic atherosclerosis correlates. We assessed whether living close to a major road and residential fine particulate matter (PM2.5) exposure were associated with TAC and AAC in a Northeastern US cohort...
March 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28292439/integrated-molecular-characterization-of-uterine-carcinosarcoma
#8
Andrew D Cherniack, Hui Shen, Vonn Walter, Chip Stewart, Bradley A Murray, Reanne Bowlby, Xin Hu, Shiyun Ling, Robert A Soslow, Russell R Broaddus, Rosemary E Zuna, Gordon Robertson, Peter W Laird, Raju Kucherlapati, Gordon B Mills, John N Weinstein, Jiashan Zhang, Rehan Akbani, Douglas A Levine
We performed genomic, epigenomic, transcriptomic, and proteomic characterizations of uterine carcinosarcomas (UCSs). Cohort samples had extensive copy-number alterations and highly recurrent somatic mutations. Frequent mutations were found in TP53, PTEN, PIK3CA, PPP2R1A, FBXW7, and KRAS, similar to endometrioid and serous uterine carcinomas. Transcriptome sequencing identified a strong epithelial-to-mesenchymal transition (EMT) gene signature in a subset of cases that was attributable to epigenetic alterations at microRNA promoters...
March 13, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28291497/variation-in-postinjury-antibiotic-prophylaxis-patterns-over-five-years-in-a-combat-zone
#9
Bradley A Lloyd, Clinton K Murray, William Bradley, Faraz Shaikh, Deepak Aggarwal, M Leigh Carson, David R Tribble
In 2008, a clinical practice guideline (CPG) was developed for the prevention of infections among combat casualties and was later revised in 2011. We evaluated utilization of antimicrobials within 48 hours following injury in the combat zone over a 5-year period (June 2009 through May 2014) with regard to number of regimens, type of antimicrobial, and adherence to the 2011 CPG. The study population consisted of 5,196 wounded military personnel. Open fractures and skin and soft-tissue injuries were the most frequent injuries...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28286927/murray-secretion-scale-and-fiberoptic-endoscopic-evaluation-of-swallowing-in-predicting-aspiration-in-dysphagic-patients
#10
Chia-Wei Kuo, Clint Tanner Allen, Chu-Chun Huang, Chia-Jung Lee
The objective of this retrospective review is to evaluate the ability of the Murray secretion scale to predict aspiration as determined by fiberoptic endoscopic evaluation of swallowing. Patients with dysphagia undergoing a fiberoptic endoscopic evaluation of swallowing study between January 2013 and November 2015 from a single, tertiary care institution were retrospectively reviewed. The Murray secretion scale and penetration aspiration scale on fiberoptic endoscopic evaluation of swallowing examination were determined...
March 12, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28280930/crisprtools-a-flexible-computational-platform-for-performing-crispr-cas9-experiments-in-the-mouse
#11
Kevin A Peterson, Glen L Beane, Leslie O Goodwin, Peter M Kutny, Laura G Reinholdt, Stephen A Murray
Genome editing using the CRISPR/Cas9 RNA-guided endonuclease system has rapidly become a driving force for discovery in modern biomedical research. This simple yet elegant system has been widely used to generate both loss-of-function alleles and precision knock-in mutations using single-stranded donor oligonucleotides. Our CRISPRtools platform supports both of these applications in order to facilitate the use of CRISPR/Cas9. While there are several tools that facilitate CRISPR/Cas9 design and screen for potential off-target sites, the process is typically performed sequentially on single genes, limiting scalability for large-scale programs...
March 9, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28274558/morbidity-and-mortality-prediction-in-pediatric-heart-surgery-physiological-profiles-and-surgical-complexity
#12
John T Berger, Richard Holubkov, Ron Reeder, David L Wessel, Kathleen Meert, Robert A Berg, Michael J Bell, Robert Tamburro, J Michael Dean, Murray M Pollack
OBJECTIVES: Outcome prediction for pediatric heart surgery has focused on mortality but mortality has been significantly reduced over the past 2 decades. Clinical care practices now emphasize reducing morbidity. Physiology-based profiles assessed by the Pediatric Risk of Mortality (PRISM) score are associated with new significant functional morbidity detected at hospital discharge. Our aims were to assess the relationship between new functional morbidity and surgical risk categories (Risk Adjustment for Congenital Heart Surgery [RACHS] and Society for Thoracic Surgery Congenital Heart Surgery Database Mortality Risk [STAT]), measure the performance of 3-level (intact survival, survival with new functional morbidity, or death) and 2-level (survival or death) PRISM prediction algorithms, and assess whether including RACHS or STAT complexity categories improves the PRISM predictive performance...
February 10, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28258591/point-of-care-ultrasound-use-accuracy-and-impact-on-clinical-decision-making-in-rwanda-hospitals
#13
Patricia C Henwood, David C Mackenzie, Andrew S Liteplo, Joshua S Rempell, Alice F Murray, Megan M Leo, Damas Dukundane, Anthony J Dean, Stephen Rulisa, Vicki E Noble
OBJECTIVES: Few studies of point-of-care ultrasound training and use in low resource settings have reported the impact of examinations on clinical management or the longer-term quality of trainee-performed studies. We characterized the long-term effect of a point-of-care ultrasound program on clinical decision making, and evaluated the quality of clinician-performed ultrasound studies. METHODS: We conducted point-of-care ultrasound training for physicians from Rwandan hospitals...
March 4, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28257438/a-population-based-matched-cohort-study-examining-the-mortality-and-costs-of-patients-with-community-onset-clostridium-difficile-infection-identified-using-emergency-department-visits-and-hospital-admissions
#14
Natasha Nanwa, Beate Sander, Murray Krahn, Nick Daneman, Hong Lu, Peter C Austin, Anand Govindarajan, Laura C Rosella, Suzanne M Cadarette, Jeffrey C Kwong
Few studies have evaluated the mortality or quantified the economic burden of community-onset Clostridium difficile infection (CDI). We estimated the attributable mortality and costs of community-onset CDI. We conducted a population-based matched cohort study. We identified incident subjects with community-onset CDI using health administrative data (emergency department visits and hospital admissions) in Ontario, Canada between January 1, 2003 and December 31, 2010. We propensity-score matched each infected subject to one uninfected subject and followed subjects in the cohort until December 31, 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28249602/relating-professionalism-and-conscientiousness-to-develop-an-objective-scalar-proxy-measure-of-professionalism-in-anaesthetic-trainees
#15
M A Sawdon, K Whitehouse, G M Finn, J C McLachlan, D Murray
BACKGROUND: The concept of professionalism is complex and subjective and relies on expert judgements. Currently, there are no existing objective measures of professionalism in anaesthesia. However, it is possible that at least some elements of professionalism may be indicated by objective measures. A number of studies have suggested that conscientiousness as a trait is a significant contributor to professionalism. METHODS: A 'Conscientiousness Index' (CI) was developed by collation of routinely collected data from tasks expected to be carried out by anaesthetic trainees such as punctual submission of holiday and 'not-on-call' requests, attendance at audit meetings, timely submission of completed appraisal documentation and sickness/absence notifications...
March 1, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28245821/gdf-15-plasma-levels-in-chronic-obstructive-pulmonary-disease-are-associated-with-subclinical-coronary-artery-disease
#16
Carlos H Martinez, Christine M Freeman, Joshua D Nelson, Susan Murray, Xin Wang, Matthew J Budoff, Mark T Dransfield, John E Hokanson, Ella A Kazerooni, Gregory L Kinney, Elizabeth A Regan, J Michael Wells, Fernando J Martinez, MeiLan K Han, Jeffrey L Curtis
BACKGROUND: Growth differentiation factor-15 (GDF-15), a cytokine associated with cardiovascular mortality, increases during chronic obstructive pulmonary disease (COPD) exacerbations, but any role in stable COPD is unknown. We tested associations between GDF-15 and subclinical coronary atherosclerosis, assessed by coronary artery calcium (CAC) score, in COPD subjects free of clinical cardiovascular disease (CVD). METHODS: Cross-sectional analysis of COPD participants (GOLD stages 2-4) in the COPDGene cohort without CVD at enrollment, using baseline CAC (from non-EKG-gated chest computed tomography) and plasma GDF-15 (by custom ELISA)...
February 28, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28236548/quantifying-blood-loss-and-transfusion-risk-after-primary-vs-conversion-total-hip-arthroplasty
#17
Jared M Newman, Matthew R Webb, Alison K Klika, Trevor G Murray, Wael K Barsoum, Carlos A Higuera
BACKGROUND: Primary total hip arthroplasty (THA) and conversion THA may result in substantial blood loss, sometimes necessitating transfusion. Despite the complexities of the latter, both are grouped in the same category for quality assessment and reimbursement. This study's purpose was to compare both blood loss and transfusion risk in primary and conversion THA and identify their associated predictors. METHODS: A total of 1616 patients who underwent primary and conversion THA at a single hospital from 2009-2013 were reviewed (primary THA = 1575; conversion THA = 41)...
February 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28229818/relationship-between-calcium-channel-blockers-and-skin-fibrosis-in-patients-with-systemic-sclerosis
#18
Guowei Li, Jonathan D Adachi, Ji Cheng, Lehana Thabane, Marie Hudson, Marvin J Fritzler, Steven Lorenzi, Murray Baron, Maggie Larché
OBJECTIVES: Recent experimental evidence suggests that calcium channel blockers (CCBs) may have anti-fibrotic effects on liver and pulmonary fibrosis. We aimed to investigate whether use of CCBs was associated with the skin fibrosis in patients with systemic sclerosis (SSc). METHODS: Based on the 5-year follow-up data from the Canadian Scleroderma Research Group registry, we used the generalised estimating equations (GEE) model to assess the relationship between use of CCBs and the primary outcome of skin fibrosis measured by the modified Rodnan skin score (mRSS)...
January 31, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28224735/genetic-risk-variants-for-social-anxiety
#19
Murray B Stein, Chia-Yen Chen, Sonia Jain, Kevin P Jensen, Feng He, Steven G Heeringa, Ronald C Kessler, Adam Maihofer, Matthew K Nock, Stephan Ripke, Xiaoying Sun, Michael L Thomas, Robert J Ursano, Jordan W Smoller, Joel Gelernter
Social anxiety is a neurobehavioral trait characterized by fear and reticence in social situations. Twin studies have shown that social anxiety has a heritable basis, shared with neuroticism and extraversion, but genetic studies have yet to demonstrate robust risk variants. We conducted genomewide association analysis (GWAS) of subjects within the Army Study To Assess Risk and Resilience in Servicemembers (Army STARRS) to (i) determine SNP-based heritability of social anxiety; (ii) discern genetic risk loci for social anxiety; and (iii) determine shared genetic risk with neuroticism and extraversion...
March 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28218661/exploring-the-effect-of-lactium%C3%A2-and-zizyphus-complex-on-sleep-quality-a-double-blind-randomized-placebo-controlled-trial
#20
Andrew Scholey, Sarah Benson, Amy Gibbs, Naomi Perry, Jerome Sarris, Greg Murray
Acute, non-clinical insomnia is not uncommon. Sufferers commonly turn to short-term use of herbal supplements to alleviate the symptoms. This placebo-controlled, double-blind study investigated the efficacy of LZComplex3 (lactium™, Zizyphus, Humulus lupulus, magnesium and vitamin B6), in otherwise healthy adults with mild insomnia. After a 7-day single-blind placebo run-in, eligible volunteers (n = 171) were randomized (1:1) to receive daily treatment for 2 weeks with LZComplex3 or placebo. Results revealed that sleep quality measured by change in Pittsburgh Sleep Quality Index (PSQI) score improved in both the LZComplex3 and placebo groups...
February 17, 2017: Nutrients
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