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JOURNAL ARTICLE
G A M Blokland, N Maleki, J Jovicich, R I Mesholam-Gately, L E DeLisi, J A Turner, M E Shenton, A N Voineskos, R S Kahn, J L Roffman, D J Holt, S Ehrlich, Z Kikinis, P Dazzan, R M Murray, J Lee, K Sim, M Lam, S M C de Zwarte, E Walton, S Kelly, M M Picchioni, E Bramon, N Makris, A S David, V Mondelli, A A T S Reinders, E Oykhman, D W Morris, M Gill, A P Corvin, W Cahn, N Ho, J Liu, R L Gollub, D S Manoach, V D Calhoun, S R Sponheim, S L Buka, S Cherkerzian, H W Thermenos, E W Dickie, S Ciufolini, T Reis Marques, N A Crossley, S M Purcell, J W Smoller, N E M van Haren, T Toulopoulou, G Donohoe, J M Goldstein, M S Keshavan, T L Petryshen, E C Del Re
Background/Objective. Enlarged lateral ventricle (LV) volume and decreased volume in the corpus callosum (CC) are hallmarks of schizophrenia (SZ). We previously showed an inverse correlation between LV and CC volumes in SZ, with global functioning decreasing with increased LV volume. This study investigates the relationship between LV volume, CC abnormalities, and the microRNA MIR137 and its regulated genes in SZ, because of MIR137's essential role in neurodevelopment. Methods . Participants were 1224 SZ probands and 1466 unaffected controls from the GENUS Consortium...
2024: International Journal of Clinical and Health Psychology: IJCHP
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JOURNAL ARTICLE
Naomi Kouri, Isabelle Frankenhauser, Zhongwei Peng, Sydney A Labuzan, Baayla D C Boon, Christina M Moloney, Cyril Pottier, Daniel P Wickland, Kelsey Caetano-Anolles, Nick Corriveau-Lecavalier, Jessica F Tranovich, Ashley C Wood, Kelly M Hinkle, Sarah J Lincoln, A J Spychalla, Matthew L Senjem, Scott A Przybelski, Erica Engelberg-Cook, Christopher G Schwarz, Rain S Kwan, Elizabeth R Lesser, Julia E Crook, Rickey E Carter, Owen A Ross, Christian Lachner, Nilüfer Ertekin-Taner, Tanis J Ferman, Julie A Fields, Mary M Machulda, Vijay K Ramanan, Aivi T Nguyen, R Ross Reichard, David T Jones, Jonathan Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jack, Kejal Kantarci, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Dennis W Dickson, Val J Lowe, Prashanthi Vemuri, Melissa E Murray
IMPORTANCE: Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate with tangle distribution and are relevant for understanding glial activation considerations in therapeutic advancement. OBJECTIVES: To examine clinicopathologic and neuroimaging characteristics of disease heterogeneity in AD along a quantitative continuum using the corticolimbic index (CLix) to account for individuality of spatially distributed tangles found at autopsy...
April 15, 2024: JAMA Neurology
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JOURNAL ARTICLE
Nessmah Sultan, Mandy Foyster, Matilda Tonkovic, Danielle Noon, Helen Burton-Murray, Jessica R Biesiekierski, Caroline J Tuck
INTRODUCTION: Orthorexia, a harmful obsession with eating healthily, may develop from illnesses characterized by dietary restriction, including irritable bowel syndrome (IBS) and eating disorders (ED). Evidence of disordered eating in IBS exists, but orthorexia has not been assessed. This cross-sectional study in adults (≥18 years) assessed presence and characteristics of disordered eating and orthorexia in IBS, compared to control subjects (CS) and ED. METHODS: IBS participants met Rome IV, and ED participants met DSM-5 criteria...
April 12, 2024: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
#4
JOURNAL ARTICLE
Tanner I Kim, Andrew DeWan, Michael Murray, He Wang, Arya Mani, Carlos Mena-Hurtado, Raul J Guzman, Cassius Iyad Ochoa Chaar
OBJECTIVES: Premature peripheral artery disease (PAD), defined by lower extremity revascularization (LER) at age ≤ 50 years, is associated with poor major adverse limb events. The early onset of disease is thought to be influenced by genetic factors that regulate homeostasis of the vascular wall and coagulation. The aim of this study is to investigate the effect of anticoagulation as an adjunct to antiplatelet therapy on the outcomes of LER in patients with premature PAD. METHODS: There were 8,804 patients with premature PAD on pre- and post-operative antiplatelet therapy only and 1,236 patients on pre- and post-operative anticoagulation plus antiplatelet therapy in the Vascular Quality Initiative (VQI) peripheral vascular intervention, infra-, and suprainguinal files...
April 7, 2024: Annals of Vascular Surgery
#5
JOURNAL ARTICLE
Orlando De Jesus, Gisela Murray, Samuel Estronza, Emil A Pastrana
INTRODUCTION: A personal watercraft is widely used for recreation on coastlines, rivers, and lakes. This study aimed to identify the spectrum of neurosurgical injuries related to personal watercraft accidents in Puerto Rico. METHODS: A retrospective study was performed utilizing the University of Puerto Rico neurosurgery database to identify patients who had been consulted to the neurosurgery service from 2005 to 2023 due to a personal watercraft-related neurosurgical injury...
March 2024: Curēus
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JOURNAL ARTICLE
N D Clement, P G Robinson, I R Murray, A D Murray, D MacDonald, P Gaston, M Moran, G J Macpherson
BACKGROUND: The health benefits of physical activity are well recognised. This study assessed whether golfers were more physically active after lower limb arthroplasty when compared to those that did not play golf (primary outcome). In addition pre and postoperative changes in health-associated quality of life (HAQoL) and joint specific outcomes between golfers and none golfers were assessed (secondary outcomes). METHODS: There were 304 patients [THA (n = 155) or TKA (n = 149)] prospectively registered during a 4-month period undergoing lower limb arthroplasty...
August 2024: Journal of Orthopaedics
#7
JOURNAL ARTICLE
Stephen Andrew Esper, Jennifer Holder-Murray, Katie Ann Meister, Hsing-Hua Sylvia Lin, David Kojo Hamilton, Yram Jan Groff, Brian Scott Zuckerbraun, Aman Mahajan
BACKGROUND: Pip is a novel digital health platform (DHP) that combines human health coaches (HCs) and technology with patient-facing content. This combination has not been studied in perioperative surgical optimization. OBJECTIVE: This study's aim was to test the feasibility of the Pip platform for deploying perioperative, digital, patient-facing optimization guidelines to elective surgical patients, assisted by an HC, at predefined intervals in the perioperative journey...
April 4, 2024: JMIR perioperative medicine
#8
JOURNAL ARTICLE
Emily N Srisarajivakul, Lauren E Fennimore, Kailey B Thornton, Jasmine Blake, Kenneth G Rice, Kris Varjas
Teacher-student relationship quality (TSRQ) predicts academic motivation (Wentzel, 1997), school engagement, and academic achievement (Hughes, 2011). However, TSRQ appears to differ across demographics. For example, boys and racially/ethnically minoritized students consistently have poorer relationships with their teachers than girls and White students (Koomen & Jellesma, 2015; Murray et al., 2008). Ensuring that TSRQ is consistently conceptualized across individuals will allow demographic differences on TSRQ to be compared...
April 4, 2024: School psychology
#9
JOURNAL ARTICLE
Matthew J Hadad, Ignacio Pasqualini, Alison K Klika, Yuxuan Jin, Matthew E Deren, Viktor E Krebs, Trevor G Murray, Nicolas S Piuzzi
BACKGROUND: The Area Deprivation Index (ADI) approximates a patient's relative socioeconomic deprivation. The ADI has been associated with increased healthcare use after TKA, but it is unknown whether there is an association with patient-reported outcome measures (PROMs). Given that a high proportion of patients are dissatisfied with their results after TKA, and the large number of these procedures performed, knowledge of factors associated with PROMs may indicate opportunities to provide support to patients who might benefit from it...
April 3, 2024: Clinical Orthopaedics and related Research
#10
Kelli Keats, Shiyuan Deng, Xianyan Chen, Tianyi Zhang, John W Devlin, David J Murphy, Susan E Smith, Brian Murray, Rishikesan Kamaleswaran, Andrea Sikora
INTRODUCTION: Intravenous (IV) medications are a fundamental cause of fluid overload (FO) in the intensive care unit (ICU); however, the association between IV medication use (including volume), administration timing, and FO occurrence remains unclear. METHODS: This retrospective cohort study included consecutive adults admitted to an ICU ≥72 hours with available fluid balance data. FO was defined as a positive fluid balance ≥7% of admission body weight within 72 hours of ICU admission...
March 22, 2024: medRxiv
#11
JOURNAL ARTICLE
Adam X Maihofer, Andrew Ratanatharathorn, Sian M J Hemmings, Karen H Costenbader, Vasiliki Michopoulos, Renato Polimanti, Alex O Rothbaum, Soraya Seedat, Elizabeth A Mikita, Alicia K Smith, Rany M Salem, Richard A Shaffer, Tianying Wu, Jonathan Sebat, Kerry J Ressler, Murray B Stein, Karestan C Koenen, Erika J Wolf, Jennifer A Sumner, Caroline M Nievergelt
Observational studies suggest that posttraumatic stress disorder (PTSD) increases risk for various autoimmune diseases. Insights into shared biology and causal relationships between these diseases may inform intervention approaches to PTSD and co-morbid autoimmune conditions. We investigated the shared genetic contributions and causal relationships between PTSD, 18 autoimmune diseases, and 3 immune/inflammatory biomarkers. Univariate MiXeR was used to contrast the genetic architectures of phenotypes. Genetic correlations were estimated using linkage disequilibrium score regression...
April 1, 2024: Translational Psychiatry
#12
JOURNAL ARTICLE
Tetyana Kendzerska, Brian J Murray, David R Colelli, Gio R Dela Cruz, Andrea S Gershon, Marcus Povitz, Robert Talarico, Mark I Boulos
OBJECTIVE: We conducted a retrospective cohort study to explore the relationship between chronotype measured by the total Morningness-Eveningness Questionnaire (MEQ) score and incident cancer. METHODS: We used clinical and provincial health administrative data on consecutive adults who underwent a Level 1 Polysomnography (PSG) and completed the MEQ between 2010 and 2015 in an academic hospital (Ontario, Canada) and were cancer-free at baseline. Cancer status was derived from the Ontario Cancer Registry...
March 21, 2024: Sleep Medicine
#13
JOURNAL ARTICLE
Pooja Middha, Rohit Thummalapalli, Michael J Betti, Lydia Yao, Zoe Quandt, Karmugi Balaratnam, Cosmin A Bejan, Eduardo Cardenas, Christina J Falcon, David M Faleck, Matthew A Gubens, Scott Huntsman, Douglas B Johnson, Linda Kachuri, Khaleeq Khan, Min Li, Christine M Lovly, Megan H Murray, Devalben Patel, Kristin Werking, Yaomin Xu, Luna Jia Zhan, Justin M Balko, Geoffrey Liu, Melinda C Aldrich, Adam J Schoenfeld, Elad Ziv
Immune checkpoint inhibitor-mediated colitis (IMC) is a common adverse event of treatment with immune checkpoint inhibitors (ICI). We hypothesize that genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) predisposes to IMC. In this study, we first develop a polygenic risk scores for CD (PRSCD ) and UC (PRSUC ) in cancer-free individuals and then test these PRSs on IMC in a cohort of 1316 patients with ICI-treated non-small cell lung cancer and perform a replication in 873 ICI-treated pan-cancer patients...
March 26, 2024: Nature Communications
#14
Zhe He, Balu Bhasuran, Qiao Jin, Shubo Tian, Karim Hanna, Cindy Shavor, Lisbeth Garcia Arguello, Patrick Murray, Zhiyong Lu
Lab results are often confusing and hard to understand. Large language models (LLMs) such as ChatGPT have opened a promising avenue for patients to get their questions answered. We aim to assess the feasibility of using LLMs to generate relevant, accurate, helpful, and unharmful responses to lab test-related questions asked by patients and to identify potential issues that can be mitigated with augmentation approaches. We first collected lab test results related question and answer data from Yahoo! Answers and selected 53 QA pairs for this study...
January 23, 2024: ArXiv
#15
JOURNAL ARTICLE
Carling G Robinson, Austin W Goodrich, Stephen D Weigand, Nha Trang Thu Pham, Arenn F Carlos, Marina Buciuc, Melissa E Murray, Aivi T Nguyen, R Ross Reichard, David S Knopman, Ronald C Petersen, Dennis W Dickson, Rene L Utianski, Jennifer L Whitwell, Keith A Josephs, Mary M Machulda
OBJECTIVE: To determine whether poorer performance on the Boston Naming Test (BNT) in individuals with transactive response DNA-binding protein 43 pathology (TDP-43+) is due to greater loss of word knowledge compared to retrieval-based deficits. METHODS: Retrospective clinical-pathologic study of 282 participants with Alzheimer's disease neuropathologic changes (ADNC) and known TDP-43 status. We evaluated item-level performance on the 60-item BNT for first and last available assessment...
March 25, 2024: Journal of the International Neuropsychological Society: JINS
#16
JOURNAL ARTICLE
Sylvia K Ofori, Emmanuelle A Dankwa, Emmanuel Ngwakongnwi, Alemayehu Amberbir, Abebe Bekele, Megan B Murray, Yonatan H Grad, Caroline O Buckee, Bethany L Hedt-Gauthier
BACKGROUND: Mathematical modeling of infectious diseases is an important decision-making tool for outbreak control. However, in Africa, limited expertise reduces the use and impact of these tools on policy. Therefore, there is a need to build capacity in Africa for the use of mathematical modeling to inform policy. Here we describe our experience implementing a mathematical modeling training program for public health professionals in East Africa. METHODS: We used a deliverable-driven and learning-by-doing model to introduce trainees to the mathematical modeling of infectious diseases...
2024: Annals of Global Health
#17
JOURNAL ARTICLE
Ester Mikova, Setor K Kunutsor, Meg Butler, James R Murray
PURPOSE: In order to assess the published validity of focal resurfacing of the knee, a systematic review and meta-analysis were conducted to (i) evaluate revision rates and implant survival of focal resurfacing of the knee; (ii) explore surgical complications; and (iii) evaluate patient reported clinical outcome measures. METHODS: PubMED, Cochrane Library and Medline databases were searched by 2 independent reviewers in February 2022 for prospective and retrospective cohort studies evaluating any of the following implant types: HemiCAP®, UniCAP®, Episealer® or BioBoly®...
March 22, 2024: Knee
#18
JOURNAL ARTICLE
Adriana Vazquez Medina, Gisela Murray Ortiz, Samuel Estronza Ojeda, Aixa de Jesus Espinosa, Emil A Pastrana
OBJECTIVE: To report the operative outcomes after treating vertebral osteomyelitis patients with an anterior cervical corpectomy and fusion procedure using recombinant human bone morphogenetic protein-2 as graft material. MATERIALS AND METHODS: A retrospective review of electronic medical records of 26 adult patients who underwent an anterior cervical corpectomy and fusion procedure for cervical osteomyelitis using rhBMP-2 at the University of Puerto Rico University District Hospital was performed...
March 18, 2024: World Neurosurgery
#19
JOURNAL ARTICLE
Eduardo Viegas da Silva, Fernando Pires Hartwig, Aisha Yousafzai, Andréa Dâmaso Bertoldi, Joseph Murray
Partnership between early childhood development interventions and primary health care services can help catalyse health care uptake by socially vulnerable families. This study aimed to assess the real-life effects of a large-scale home visiting programme [Primeira Infância Melhor (PIM)] in Brazil on the use of preventive (prenatal visits, well child visits, dentist visits and vaccination) and recovery (emergency room visits and hospitalization) health services. A quasi-experiment nested in a population-based birth cohort study was conducted...
February 29, 2024: Health Policy and Planning
#20
JOURNAL ARTICLE
Nickelas Huffman, Ignacio Pasqualini, Roberta E Redfern, Trevor G Murray, Matthew E Deren, Craig L Israelite, Charles L Nelson, Dave Van Andel, Jason M Cholewa, Mike B Anderson, Alison K Klika, John P McLaughlin, Nicolas S Piuzzi
PURPOSE: Obesity has been identified as a risk factor for postoperative complications in patients undergoing total hip arthroplasty (THA). This study aimed to investigate patient-reported outcomes, pain, and satisfaction as a function of body mass index (BMI) class in patients undergoing THA. METHODS: 1736 patients within a prospective observational study were categorized into BMI classes. Pre- and postoperative Hip disability and Osteoarthritis Outcome Score for Joint Replacement (HOOS JR), satisfaction, and pain scores were compared by BMI class using one-way ANOVA...
March 15, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
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