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https://www.readbyqxmd.com/read/28918761/quality-of-life-in-bipolar-disorder-towards-a-dynamic-understanding
#1
E Morton, G Murray, E E Michalak, R W Lam, S Beaulieu, V Sharma, P Cervantes, S V Parikh, L N Yatham
BACKGROUND: Although quality of life (QoL) is receiving increasing attention in bipolar disorder (BD) research and practice, little is known about its naturalistic trajectory. The dual aims of this study were to prospectively investigate: (a) the trajectory of QoL under guideline-driven treatment and (b) the dynamic relationship between mood symptoms and QoL. METHODS: In total, 362 patients with BD receiving guideline-driven treatment were prospectively followed at 3-month intervals for up to 5 years...
September 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28911268/apathy-not-depressive-symptoms-as-a-predictor-of-semantic-and-phonemic-fluency-task-performance-in-stroke-and-transient-ischemic-attack
#2
Keera N Fishman, Andrea R Ashbaugh, Krista L Lanctôt, Megan L Cayley, Nathan Herrmann, Brian J Murray, Michelle Sicard, Karen Lien, Demetrios J Sahlas, Richard H Swartz
OBJECTIVES: This study examined the relationship between apathy and cognition in patients with cerebrovascular disease. Apathy may result from damage to frontal subcortical circuits causing dysexecutive syndromes, but apathy is also related to depression. We assessed the ability of apathy to predict phonemic fluency and semantic fluency performance after controlling for depressive symptoms in 282 individuals with stroke and/or transient ischemic attack. METHOD: Participants (N = 282) completed the Phonemic Fluency Test, Semantic Fluency Test, Center for Epidemiologic Studies Depression Scale, and Apathy Evaluation Scale...
September 15, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28910913/-effect-of-transcutaneous-oximetry-on-prognosis-of-patients-with-severe-acute-respiratory-failure-receiving-extracorporeal-membrane-oxygenation
#3
L Dong, X H Zhang, F M Liang, T Yang, J Yan, Z Yan, L Li
Objective: To investigate the prognostic value of transcutaneous oximetry in patients with severe acute respiratory failure receiving extracorporeal membrane oxygenation(ECMO). Methods: Forty-nine patients diagnosed as severe acute respiratory failure receiving Venous-Venous(V-V)ECMO were enrolled from January 2013 to December 2015 in intensive care unit(ICU) of Wuxi People's Hospital Affiliated to Nanjing Medical University.The 10-min oxygen challenge test was performed using transcutaneous oximetry 6 h after the initiation of ECMO, and the 10-min oxygen challenge test value(OCT(10)) and oxygen challenge index(OCI) were calculated...
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28902444/genomewide-association-studies-of-suicide-attempts-in-us-soldiers
#4
Murray B Stein, Erin B Ware, Colter Mitchell, Chia-Yen Chen, Susan Borja, Tianxi Cai, Catherine L Dempsey, Carol S Fullerton, Joel Gelernter, Steven G Heeringa, Sonia Jain, Ronald C Kessler, James A Naifeh, Matthew K Nock, Stephan Ripke, Xiaoying Sun, Jean C Beckham, Nathan A Kimbrel, Robert J Ursano, Jordan W Smoller
Suicide is a global public health problem with particular resonance for the US military. Genetic risk factors for suicidality are of interest as indicators of susceptibility and potential targets for intervention. We utilized population-based nonclinical cohorts of US military personnel (discovery: N = 473 cases and N = 9778 control subjects; replication: N = 135 cases and N = 6879 control subjects) and a clinical case-control sample of recent suicide attempters (N = 51 cases and N = 112 control subjects) to conduct GWAS of suicide attempts (SA)...
September 13, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28901887/microcytosis-is-associated-with-low-cognitive-outcomes-in-healthy-2-year-olds-in-a-high-resource-setting
#5
Elaine K McCarthy, Mairead E Kiely, Geraldine Hannon, Caroline Ahearne, Louise C Kenny, Jonathan O'B Hourihane, Alan D Irvine, Deirdre M Murray
Fe deficiency in early childhood is associated with long-term consequences for cognitive, motor and behavioural development; however explorations in healthy children from low risk, high-resource settings have been limited. We aimed to explore associations between Fe status and neurodevelopmental outcomes in low risk, healthy 2-year-olds. This study was a secondary analysis of a nested case-control subgroup from the prospective, maternal-infant Cork Babies after Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact using Neurological and Nutritional Endpoints (BASELINE) Birth Cohort Study...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28899440/the-impact-of-social-media-promotion-with-infographics-and-podcasts-on-research-dissemination-and-readership
#6
Brent Thoma, Heather Murray, Simon York Ming Huang, William Ken Milne, Lynsey J Martin, Christopher M Bond, Rohit Mohindra, Alvin Chin, Calvin H Yeh, William B Sanderson, Teresa M Chan
OBJECTIVE: In 2015 and 2016, the Canadian Journal of Emergency Medicine (CJEM) Social Media (SoMe) Team collaborated with established medical websites to promote CJEM articles using podcasts and infographics while tracking dissemination and readership. METHODS: CJEM publications in the "Original Research" and "State of the Art" sections were selected by the SoMe Team for podcast and infographic promotion based on their perceived interest to emergency physicians...
September 13, 2017: CJEM
https://www.readbyqxmd.com/read/28891713/effect-of-preoperative-deformity-on-arthroscopic-and-open-ankle-fusion-outcomes
#7
Timo Schmid, Fabian Krause, Murray J Penner, Andrea Veljkovic, Alastair S E Younger, Kevin Wing
INTRODUCTION: Coronal deformity is considered a relative contraindication for arthroscopic ankle fusion. This study assessed whether preoperative coronal ankle joint deformity influenced the outcome of arthroscopic ankle fusion. METHODS: Ninety-seven patients had 62 arthroscopic and 35 open ankle fusions between 2005 and 2012. Clinical outcomes were prospectively recorded with use of the Ankle Osteoarthritis Scale (AOS) and Ankle Arthritis Scale (AAS) preoperatively and at 6, 12, and 24 months and final follow-up...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28890185/stromal-clusterin-expression-predicts-therapeutic-response-to-neoadjuvant-chemotherapy-in-triple-negative-breast-cancer
#8
Yihong Wang, Alexander S Brodsky, Jinjun Xiong, Mary L Lopresti, Dongfang Yang, Murray B Resnick
BACKGROUND: Expression of clusterin correlates with tumor progression and therapeutic response in several human malignancies, including breast cancer. However, its predictive value in the neoadjuvant setting in breast cancer remains unexplored. The objective of this explorative study was to determine whether clusterin expression in breast cancer correlated with clinical pathologic characteristics and whether its expression was predictive of response to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS: We determined the clusterin expression pattern in 72 triple negative breast cancers (TNBC) treated with NAC before surgery...
August 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28853718/genetic-correlations-between-intraocular-pressure-blood-pressure-and-primary-open-angle-glaucoma-a-multi-cohort-analysis
#9
Hugues Aschard, Jae H Kang, Adriana I Iglesias, Pirro Hysi, Jessica N Cooke Bailey, Anthony P Khawaja, R Rand Allingham, Allison Ashley-Koch, Richard K Lee, Sayoko E Moroi, Murray H Brilliant, Gadi Wollstein, Joel S Schuman, John H Fingert, Donald L Budenz, Tony Realini, Terry Gaasterland, William K Scott, Kuldev Singh, Arthur J Sit, Robert P Igo, Yeunjoo E Song, Lisa Hark, Robert Ritch, Douglas J Rhee, Vikas Gulati, Shane Haven, Douglas Vollrath, Donald J Zack, Felipe Medeiros, Robert N Weinreb, Ching-Yu Cheng, Daniel I Chasman, William G Christen, Margaret A Pericak-Vance, Yutao Liu, Peter Kraft, Julia E Richards, Bernard A Rosner, Michael A Hauser, Caroline C W Klaver, Cornelia M vanDuijn, Jonathan Haines, Janey L Wiggs, Louis R Pasquale
Primary open-angle glaucoma (POAG) is the most common chronic optic neuropathy worldwide. Epidemiological studies show a robust positive relation between intraocular pressure (IOP) and POAG and modest positive association between IOP and blood pressure (BP), while the relation between BP and POAG is controversial. The International Glaucoma Genetics Consortium (n=27 558), the International Consortium on Blood Pressure (n=69 395), and the National Eye Institute Glaucoma Human Genetics Collaboration Heritable Overall Operational Database (n=37 333), represent genome-wide data sets for IOP, BP traits and POAG, respectively...
August 30, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28845603/comparison-of-anterior-segment-health-in-wild-and-captive-common-murres
#10
Kate S Freeman, Christine Fiorello, Michael Murray
OBJECTIVE: To evaluate and compare the anterior segment health of wild and captive common murres. PROCEDURES: Thirty wild common murres (Uria aalge) were captured and housed in freshwater pools and had an adnexal and anterior segment exam performed prior to a subsequent wildlife health study. The examination included phenol red thread tear tests, fluorescein staining, slit-lamp biomicroscopy, rebound tonometry, and conjunctival culture sampling. Six captive common murres housed in natural seawater at the Monterey Bay Aquarium were examined in a similar manner...
August 27, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28844798/utility-of-the-autism-observation-scale-for-infants-in-early-identification-of-autism-in-tuberous-sclerosis-complex
#11
Jamie K Capal, Paul S Horn, Donna S Murray, Anna Weber Byars, Nicole M Bing, Bridget Kent, Lindsey A Bucher, Marian E Williams, Sarah O'Kelley, Deborah A Pearson, Mustafa Sahin, Darcy A Krueger
BACKGROUND: Tuberous sclerosis complex (TSC) is a genetic disorder with high prevalence of associated autism spectrum disorder (ASD). Our primary objectives were to determine early predictors of autism risk to identify children with TSC in most need of early interventions. The Autism Observation Scale for Infants (AOSI) was evaluated as a measure of ASD-associated behaviors in infants with TSC at age 12 months and its ability to predict ASD at 24 months. METHODS: Children ages 0 to 36 months with TSC were enrolled in the TSC Autism Center of Excellence Research Network (TACERN), a multicenter, prospective observational study to identify biomarkers of ASD...
June 27, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28839245/hypermasculinised-facial-morphology-in-boys-and-girls-with-autism-spectrum-disorder-and-its-association-with-symptomatology
#12
Diana Weiting Tan, Syed Zulqarnain Gilani, Murray T Maybery, Ajmal Mian, Anna Hunt, Mark Walters, Andrew J O Whitehouse
Elevated prenatal testosterone exposure has been associated with Autism Spectrum Disorder (ASD) and facial masculinity. By employing three-dimensional (3D) photogrammetry, the current study investigated whether prepubescent boys and girls with ASD present increased facial masculinity compared to typically-developing controls. There were two phases to this research. 3D facial images were obtained from a normative sample of 48 boys and 53 girls (3.01-12.44 years old) to determine typical facial masculinity/femininity...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28831821/long-term-outcomes-of-over-8-000-medial-oxford-phase-3-unicompartmental-knees-a-systematic-review
#13
Hasan R Mohammad, Louise Strickland, Thomas W Hamilton, David W Murray
Background and purpose - There is debate as to the relative merits of unicompartmental and total knee arthroplasty (UKA, TKA). Although the designer surgeons have achieved good results with the Oxford UKA there is concern over the reproducibility of these outcomes. Therefore, we evaluated published long-term outcomes of the Oxford Phase 3 UKA. Patients and methods - We searched databases to identify studies reporting ≥10 year outcomes of the medial Oxford Phase 3 UKA. Revision, non-revision, and re-operation rates were calculated per 100 component years (% pa)...
August 23, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28831554/the-impact-of-patient-specific-instrumentation-on-unicompartmental-knee-arthroplasty-a-prospective-randomised-controlled-study
#14
Abtin Alvand, Tanvir Khan, Cathy Jenkins, Jonathan L Rees, William F Jackson, Christopher A F Dodd, David W Murray, Andrew J Price
PURPOSE: Patient-specific instrumentation (PSI) has been proposed as a means of improving surgical accuracy and ease of implantation during technically challenging procedures such as unicompartmental knee arthroplasty (UKA). The purpose of this prospective randomised controlled trial was to compare the accuracy of implantation and functional outcome of mobile-bearing medial UKAs implanted with and without PSI by experienced UKA surgeons. METHODS: Mobile-bearing medial UKAs were implanted in 43 patients using either PSI guides or conventional instrumentation...
August 22, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28782118/undetectable-negative-tissue-transglutaminase-iga-antibodies-predict-mucosal-healing-in-treated-coeliac-disease-patients
#15
H Fang, K S King, J J Larson, M R Snyder, T T Wu, M J Gandhi, J A Murray
BACKGROUND: Tissue transglutaminase (tTG) immunoglobulin A (IgA) testing is a sensitive adjunct to the diagnosis of coeliac disease. The threshold for positivity was developed for diagnosis, with negative results reported as below the reference value (<4 U/mL). AIM: To investigate if an undetectable (tTG IgA<1.2 U/mL) is more predictive of healing compared to patients with negative but detectable serology (1.2-3.9 U/mL). METHODS: We performed a retrospective study of 402 treated coeliac disease patients seen at the Mayo Clinic with negative tTG IgA values drawn within 1 month of duodenal biopsy between January 2009 and December 2015...
August 7, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28771633/methodological-quality-of-systematic-reviews-referenced-in-clinical-practice-guidelines-for-the-treatment-of-opioid-use-disorder
#16
Andrew Ross, Justin Rankin, Jason Beaman, Kelly Murray, Philip Sinnett, Ross Riddle, Jordan Haskins, Matt Vassar
INTRODUCTION: With efforts to combat opioid use disorder, there is an increased interest in clinical practice guidelines (CPGs) for opioid use disorder treatments. No literature exists examining the quality of systematic reviews used in opioid use disorder CPGs. This study aims to describe the methodological quality and reporting clarity of systematic reviews (SRs) used to create CPGs for opioid use disorder. METHODS: From June to July 2016 guideline clearinghouses and medical literature databases were searched for relevant CPGs used in the treatment of opioid use disorder...
2017: PloS One
https://www.readbyqxmd.com/read/28767031/microsurgical-vascular-manipulation-in-aneurysm-surgery-and-delayed-ischemic-injury
#17
Muhammad Omar Chohan, Andrew P Carlson, Cristina Murray-Krezan, Christopher L Taylor, Howard Yonas
BACKGROUND: The role of aggressive surgical manipulation with clot evacuation, arachnoid dissection, and papaverine-guided adventitial dissection of large vessels during ruptured aneurysm surgery in reducing vasospasm is controversial. Here we describe a single-institution experience in aneurysm surgery outcomes with and without aggressive surgery. METHODS: We performed retrospective analysis of all patients >18 years of age with subarachnoid hemorrhage (SAH) from anterior circulation aneurysms between 2008 and 2013 at the University of New Mexico Hospital...
July 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28755878/hyperprolactinaemia-in-first-episode-psychosis-a-longitudinal-assessment
#18
John Lally, Olesya Ajnakina, Brendon Stubbs, Hugh R Williams, Marco Colizzi, Elena Carra, Sara Fraietta, Poonam Gardner-Sood, Kathryn E Greenwood, Zerrin Atakan, Valeria Mondelli, Khalida Ismail, Oliver Howes, David M Taylor, Shubalade Smith, David Hopkins, Robin M Murray, Fiona Gaughran
Little is known about hyperprolactinaemia (HPL) in first episode psychosis (FEP) patients. We investigated longitudinal changes in serum prolactin in FEP, and the relationship between HPL, and antipsychotic medication and stress. Serum prolactin was recorded in FEP patients at recruitment and again, 3 and 12months later. HPL was defined as a serum prolactin level >410mIU/L (~19.3ng/ml) for males, and a serum prolactin level >510mIU/L (~24.1ng/ml) for females. From a total of 174 people with serum prolactin measurements at study recruitment, 43% (n=74) had HPL, whilst 27% (n=21/78) and 27% (n=26/95) had HPL at 3 and 12months respectively...
July 27, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28755266/latiglutenase-improves-symptoms-in-seropositive-celiac-disease-patients-while-on-a-gluten-free-diet
#19
Jack A Syage, Joseph A Murray, Peter H R Green, Chaitan Khosla
BACKGROUND AND AIMS: Celiac disease (CD) is a widespread condition triggered by dietary gluten and treated with a lifelong gluten-free diet (GFD); however, inadvertent exposure to gluten can result in episodic symptoms. A previous trial of latiglutenase (clinicaltrials.gov; NCT01917630), an orally administered mixture of two recombinant gluten-specific proteases, was undertaken in symptomatic subjects with persistent injury. The primary endpoint for histologic improvement was not met, presumably due to a trial effect...
July 28, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28754583/utilising-symptom-dimensions-with-diagnostic-categories-improves-prediction-of-time-to-first-remission-in-first-episode-psychosis
#20
Olesya Ajnakina, John Lally, Marta Di Forti, Simona A Stilo, Anna Kolliakou, Poonam Gardner-Sood, Paola Dazzan, Carmine Pariante, Tiago Reis Marques, Valeria Mondelli, James MacCabe, Fiona Gaughran, Anthony S David, Daniel Stamate, Robin M Murray, Helen L Fisher
There has been much recent debate concerning the relative clinical utility of symptom dimensions versus conventional diagnostic categories in patients with psychosis. We investigated whether symptom dimensions rated at presentation for first-episode psychosis (FEP) better predicted time to first remission than categorical diagnosis over a four-year follow-up. The sample comprised 193 FEP patients aged 18-65years who presented to psychiatric services in South London, UK, between 2006 and 2010. Psychopathology was assessed at baseline with the Positive and Negative Syndrome Scale and five symptom dimensions were derived using Wallwork/Fortgang's model; baseline diagnoses were grouped using DSM-IV codes...
July 25, 2017: Schizophrenia Research
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